Effect of sodium ‐glucose cotransporter 2 inhibitor, empagliflozin, and α‐glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes
ConclusionWe suggest that this metabolic improvement might be related to SIRT1 and AMPK pathway in T2DM. But empagliflozin is thought to have more advantage to prevent hepatic steatosis than voglibose in T2DM. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Ji ‐Won Kim, Ye‐Jee Lee, Young‐Hye You, Min Kyong Moon, Kun‐Ho Yoon, Yu‐Bae Ahn, Seung‐Hyun Ko Tags: RESEARCH ARTICLE Source Type: research

Shen ’ge powder decreases the cardiomyocyte hypertrophy in chronic heart failure by activating the Rho protein/Rho‐associated coiledcoil forming protein kinase signaling pathway
ConclusionShen ’ge powder could reduce cardiomyocyte hypertrophy in CHF by regulating the Rho/ROCK signaling pathway. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xinpeng Yan, Kai Jiao, Xiaozheng Song Tags: RESEARCH ARTICLE Source Type: research

Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis
ConclusionCYG could apparently release the tinnitus symptoms in the patients with chronic nephritis. This study might give more clinical evidence for Cistanche in the treatment of tinnitus and give a new treatment method for the patients with tinnitus. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xiaoli Fan, Yue Chen, Li Li, Yang Wang, Yi Zhang, Shan Lu, Danyang Zhu, Meixiao Sheng Tags: RESEARCH ARTICLE Source Type: research

Identification of NPAC as a novel biomarker and regulator for hepatocellular carcinoma
ConclusionsThese results suggest that NPAC may play an important role in the development and progression of HCC, and can act as a novel potential prognostic biomarker and therapeutic target for HCC. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Jiecheng Zhang, Nannan Sun, Wenfeng Guo, Xiaojie Wu, Xiaoying Yang, Haiyong Jin, Yueling Zhang, Xiaoting Wu, Fenglian Zhang, Ling Hu, Huiling Hu, Yong Gao Tags: RESEARCH ARTICLE Source Type: research

The interaction between ANXA2 and lncRNA Fendrr promotes cell apoptosis in caerulein ‐induced acute pancreatitis
ConclusionOur study demonstrated that ANXA2 promoted AP progression via interacting with lncRNA Fendrr in vitro, which will provide a novel insight into the therapeutic target for AP. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Dali Zhao, Huajun Ge, Biao Ma, Dongbo Xue, Weihui Zhang, Zhituo Li, Haijun Sun Tags: RESEARCH ARTICLE Source Type: research

Virtual screening of National Cancer Institute database for claudin ‐4 inhibitors: Synthesis, biological evaluation, and molecular dynamics studies
In the present work, structure ‐based virtual screening is performed with the National Cancer Institute (NCI) database using Glide. Molecular dynamics simulations of membrane protein were used for optimization of the top‐three lead compounds (NCI110039, NCI344682, and NCI661251) with claudin‐4 in a dynamic system. Synthesis of the NCI110039 was performed. Cytotoxicity assays proved that purpurogallin carboxylic acid has the inhibitory effect towards breast (MCF7) and lung (A549) cancer cell lines. AbstractClaudin ‐4 (CLDN4) is a vital member of tight‐junction proteins that is often overexpressed in cancer and oth...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Majji Rambabu, Sivaraman Jayanthi Tags: RESEARCH ARTICLE Source Type: research

Disorders in NADPH generation via pentose phosphate pathway influence the reproductive potential of the Saccharomyces cerevisiae yeast due to changes in redox status
In this study, we examine the impact of redox homoeostasis on cellular physiology and proliferation. We have noted that the Δzwf1 mutant lacking the rate ‐limiting enzyme of the PP pathway shows changes in the cellular redox status caused by disorders in NADPH generation. This leads to a decrease in reproductive potential but without affecting the total lifespan of the cell. The results presented in this paper show that nicotine adenine dinucleotid es play a central role in cellular physiology. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Magdalena Kwolek ‐Mirek, Roman Maslanka, Mateusz Molon Tags: RESEARCH ARTICLE Source Type: research

Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho ‐associated protein kinase 1
In this study we found that POU3F3 and rho‐associated protein kinase 1 (ROCK1) were both increased in tumor tissues than in adjacent healthy tissues of patients with prostate carcinoma. Expression levels of POU3F3 increased with increase in the diameter of tumor but were not significantly affected by lymph node metastasis or distant metastasis. Expression levels of POU3F3 and ROCK1 were positive correlated in tumor tissues but not in adjacent healthy tissues. POU3F3 and ROCK1 overexpression promoted, while ROCK1 knockdown inhibited the proliferation of prostate carcinoma cells. ROCK1 knockdown reduced the enhancing effec...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Xiaodong Wan, Jun Xiang, Qimin Zhang, Cuidong Bian Tags: RESEARCH ARTICLE Source Type: research

LncRNA C2dat1 enhances vascular smooth muscle cell proliferation and migration by targeting MiR ‐34a‐5p
In this study, we showed that the expression level of C2dat1 was higher in coronary artery disease (CAD) tissues than in normal arterial tissues and the C2dat1 expression level was upregulated in the prolif erating VSMC after being treated with PDGF‐bb or TNF‐α. In addition, we indicated that overexpression of C2dat1 promoted VSMC growth and enhanced PCNA expression in VSMC. Moreover, ectopic expression of C2dat1 increased VSMC migration. Furthermore, we showed that elevated expression of C2dat1 s uppressed miR‐34a expression and promoted sirtuin 1 (SIRT1) expression, which was a direct target gene of miR‐34a. We ...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Hairong Wang, Zhili Jin, Tu Pei, Wenhao Song, Yao Gong, Deliang Chen, Lin Zhang, Meichun Zhang, Gangchen Zhang Tags: RESEARCH ARTICLE Source Type: research

Chinese herbal decoction of Wenshen Yangxue formula improved fertility and pregnancy rate in mice through PI3K/Akt signaling
ConclusionThese results suggested the herbal decoctions promoted the fertilization of mice, which was related to the charge of PI3K/Akt activation. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Mingwei Xin, Junqin He, Ying Zhang, Ying Wu, Wei Yang, Xinyun Liang, Xiaodan Yin Tags: RESEARCH ARTICLE Source Type: research

Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells
This study focused on the antisenescence effect of four plant species (Falcaria vulgaris, Ixiolirion tataricum, Ajuga chamaecistus, andScabiosa flavida) on H2O2‐induced premature senescence in rat NIH3T3 fibroblasts, which were found to be rich in effective phytochemicals with traditional ethnobotanical backgrounds. Plant materials were collected, identified, and extracted. To determine the viability of NIH3T3 cells, an MTT assay was conducted. The level s of OS markers and the senescence‐associated ß‐galactosidase (SA‐ß‐GAL) activity were analyzed by the Elisa reader. The cell cycle pattern was evaluated by fl...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Saeideh Momtaz, Maryam Baeeri, Mahban Rahimifard, Hamed Haghi ‐Aminjan, Shokoufeh Hassani, Mohammad Abdollahi Tags: RESEARCH ARTICLE Source Type: research

LncRNA H19/miR ‐194/PFTK1 axis modulates the cell proliferation and migration of pancreatic cancer
MiR ‐194 messenger RNA expression was dramatically downregulated in pancreatic ductal adenocarcinoma (PDAC) tissues, and was negatively correlated with long noncoding RNA (lncRNA) H19 and PFTK1, suggesting that rescuing miR‐194 expression in PDAC, therefore inhibiting lncRNA H19 and PFTK1, subsequen tly suppressing PDAC cell proliferation and migration might make contribution to the treatment of PDAC. AbstractPancreatic ductal adenocarcinoma (PDAC) remains a huge challenge due to its high mortality and morbidity; gene therapy might be a promising treatment for PDAC. The critical role of Wnt ‐signaling pathway in canc...
Source: Journal of Cellular Biochemistry - November 26, 2018 Category: Biochemistry Authors: Yunpeng Sun, Qiandong Zhu, Wenjun Yang, Yunfeng Shan, Zhengping Yu, Qiyu Zhang, Huanhuan Wu Tags: RESEARCH ARTICLE Source Type: research

Polycystins in disease mechanobiology
In this study, we highlight emerging data that support the overall contribution of polycystins to disease mechanobiology and suggest further exploration of this protein family in diseases generated from force‐bearing tissue structures. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Antonios N. Gargalionis, Efthimia K. Basdra, Athanasios G. Papavassiliou Tags: PROSPECTS Source Type: research

Kanamycin induces free radicals formation in melanocytes: An important factor for aminoglycosides ototoxicity
Previously we demonstrated that kanamycin disturbs homeostasis in light ‐pigmented melanocytes. To investigate if/how melanization contributes to this phenomenon, the study using in vitro model of dark‐pigmented melanocytes were performed. The obtained results were compared with data concerning light‐pigmented melanocytes and the role of melanin in the mechanism o f kanamycin‐induced hearing impairment was revealed. AbstractOtotoxicity is well ‐documented but not fully understood undesirable side effect of aminoglycoside antibiotic, kanamycin. Kanamycin is capable of binding to melanin biopolymers—natural pigme...
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Dorota Wrze śniok, Jakub Rok, Artur Beberok, Zuzanna Rzepka, Michalina Respondek, Barbara Pilawa, Magdalena Zdybel, Marcin Delijewski, Ewa Buszman Tags: RESEARCH ARTICLE Source Type: research

Cover Image, Volume 120, Number 1, January 2019
Cover: The cover image, by Dolati et al, is based on the Review Article,Mesenchymal stem cell and bone marrow mononuclear cell therapy for cardiomyopathy: From bench to bedside, DOI:10.1002/jcb.27531. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 21, 2018 Category: Biochemistry Authors: Sanam Dolati, Mehdi Yousefi, Mahdi Mahdipour, Abbas Afrasiabi Rad, Alireza Pishgahi, Mohammad Nouri, Ahmad Reza Jodati Tags: COVER Source Type: research