Journal of Cellular and Molecular Medicine 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Pharmacological effects of berberine on mood disorders
AbstractBerberine, a natural isoquinoline alkaloid, is used in herbal medicine and has recently been shown to have efficacy in the treatment of mood disorders. Furthermore, berberine modulates neurotransmitters and their receptor systems within the central nervous system. However, the detailed mechanisms of its action remain unclear. This review summarizes the pharmacological effects of berberine on mood disorders. Therefore, it may be helpful for potential application in the treatment of mood disorders. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Jie Fan,
Kun Zhang,
Yang Jin,
Bingjini Li,
Shuohui Gao,
Jiaming Zhu,
Ranji Cui Tags: REVIEW Source Type: research
Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKC ζ‐mediated phosphorylation of occludin
This study demonstrates that metformin improves TJ barrier function by promoting the abundance and assembly of full length occludin at the TJ and that this process involves phosphorylation of the protein via an AMPK‐PKCζ pathway. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Kameljit K. Kalsi,
James P. Garnett,
Wishwanath Patkee,
Alexina Weekes,
Mark E. Dockrell,
Emma H. Baker,
Deborah L. Baines Tags: ORIGINAL ARTICLE Source Type: research
Clinical association of metabolic syndrome, C ‐reactive protein and testosterone levels with clinically significant prostate cancer
AbstractRecently, the influence that metabolic syndrome (MetS), hormonal alterations and inflammation might have on prostate cancer (PCa) risk has been a subject of controversial debate. Herein, we aimed to investigate the association between MetS ‐components, C‐reactive protein (CRP) and testosterone levels, and the risk of clinically significant PCa (Sig‐PCa) at the time of prostate biopsy. For that, men scheduled for transrectal ultrasound guided biopsy of the prostate were studied. Clinical, laboratory parameters and criteria for Me tS characterization just before the biopsy were collected. A total of 524 patient...
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Enrique G ómez‐Gómez,
Julia Carrasco‐Valiente,
Juan Pablo Campos‐Hernández,
Ana Maria Blanca‐Pedregosa,
Juan Manuel Jiménez‐Vacas,
Jesus Ruiz‐García,
Jose Valero‐Rosa,
Raul Miguel Luque,
María José Requena‐Tapia Tags: ORIGINAL ARTICLE Source Type: research
DLG5 suppresses breast cancer stem cell ‐like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression
AbstractTamoxifen (TAM) is a primary drug for treatment of estrogen receptor positive breast cancer. However, TAM resistance remains a serious threat to breast cancer patients and may be attributed to increased stemness of breast cancer. Here, we show that discs large homolog 5 (DLG5) expression is down ‐regulated in TAM‐resistant breast cancer and cells. DLG5 silencing decreased the sensitivity to TAM and increased the frequency and stemness of CD44+/CD24− breast cancer stem cells (BCSCs) and TAZ, a transducer of the Hippo pathway, expression in MCF7 cells while DLG5 overexpression had opposite effects. TAZ silencin...
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Jie Liu,
Juan Li,
Pingping Li,
Yina Jiang,
He Chen,
Ruiqi Wang,
Fang Cao,
Peijun Liu Tags: ORIGINAL ARTICLE Source Type: research
Immunometabolism features of metabolic deregulation and cancer
AbstractImmunometabolism is a branch dealing at the interface of immune functionalities and metabolic regulations. Considered as a bidirectional trafficking, metabolic contents and their precursors bring a considerable change in immune cells signal transductions which as a result affect the metabolic organs and states as an implication. Lipid metabolic ingredients form a major chunk of daily diet and have a proven contribution in immune cells induction, which then undergo metabolic pathway shuffling inside their ownself. Lipid metabolic states activate relevant metabolic pathways inside immune cells that in turn prime appr...
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Xue Wang,
Feng ‐Feng Ping,
Sahar Bakht,
Jingjing Ling,
Waseem Hassan Tags: REVIEW Source Type: research
Whole exome sequencing identified a novel DAG1 mutation in a patient with rare, mild and late age of onset muscular dystrophy ‐dystroglycanopathy
AbstractMuscular dystrophy ‐dystroglycanopathy (limb‐girdle), type C, 9 (MDDGC9) is the rarest type of autosomal recessive muscular dystrophies. MDDGC9 is manifested with an early onset in childhood. Patients with MDDGC9 usually identified with defective glycosylation of DAG1, hence it is known as “dystroglycanopathies” . Here, we report a Chinese pedigree presented with mild MDDGC9. The proband is a 64 years old Chinese man. In this family, both the proband and proband's younger brother have been suffering from mild and late onset MDDGC9. Muscle biopsy showed that the left deltoid muscle with an advanced stage of...
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Yi Dai,
Shengran Liang,
Xue Dong,
Yanhuan Zhao,
Haitao Ren,
Yuzhou Guan,
Haifang Yin,
Chen Li,
Lin Chen,
Liying Cui,
Santasree Banerjee Tags: ORIGINAL ARTICLE Source Type: research
TSG101 promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by regulating the PEG10
In conclusion, these results suggest that TSG101 is up‐regulated in human HCC pa tients, which may accelerate the proliferation, migration and invasion of HCC cells through regulating PEG10. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Zhiyi Liu,
Zilu Tian,
Kuan Cao,
Bin Zhang,
Quan Wen,
Xinyu Zhou,
Weibin Yang,
Tao Wang,
Hengliang Shi,
Renhao Wang Tags: ORIGINAL ARTICLE Source Type: research
Mast cell tetrahydrobiopterin contributes to itch in mice
AbstractGTP cyclohydrolase (GCH1) governs de novo synthesis of the enzyme cofactor, tetrahydrobiopterin (BH4), which is essential for biogenic amine production, bioactive lipid metabolism and redox coupling of nitric oxide synthases. Overproduction of BH4 via upregulation of GCH1 in sensory neurons is associated with nociceptive hypersensitivity in rodents, and neuron ‐specific GCH1 deletion normalizes nociception. The translational relevance is revealed by protective polymorphisms of GCH1 in humans, which are associated with a reduced chronic pain. Because myeloid cells constitute a major non‐neuronal source of BH4 th...
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Katja Zschiebsch,
Caroline Fischer,
Annett Wilken ‐Schmitz,
Gerd Geisslinger,
Keith Channon,
Katrin Watschinger,
Irmgard Tegeder Tags: ORIGINAL ARTICLE Source Type: research
Polymorphism in the PBX1 gene is related to cystinuria in Brazilian families
AbstractThe aim of our study was to determine regions of loss of heterozygosity, copy number variation analysis, and single nucleotide polymorphisms (SNPs) in Brazilian patients with cystinuria. A linkage study was performed using DNA samples from six patients with cystinuria and six healthy individuals. Genotyping was done with the Genome ‐Wide Human SNP 6.0 arrays (Affymetrix, Inc., Santa Clara, CA, USA). For validation, SNPs were genotyped using a TaqMan® SNP Genotyping Assay Kit. The homozygote polymorphic genotype of SNP rs17383719 in the gene PBX1 was more frequent (P = 0.015) in cystinuric patients. The presence ...
Source: Journal of Cellular and Molecular Medicine - November 18, 2018 Category: Molecular Biology Authors: Sabrina T. Reis,
Katia R. M. Leite,
Giovanni S. Marchini,
Ronaldo M. Guimar ães,
Nayara I. Viana,
Ruan C. A. Pimenta,
Fabio C. Torricelli,
Alexandre Danilovic,
Fábio Carvalho Vicentini,
William Carlos Nahas,
Miguel Srougi,
Eduardo Mazzucchi Tags: SHORT COMMUNICATION Source Type: research
Vildagliptin improves high glucose ‐induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission
In conclusion, VLD improves endothelial mitochondrial dysfunction in diabetes , possibly through inhibiting Drp1‐mediated mitochondrial fission in an AMPK‐dependent manner. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 16, 2018 Category: Molecular Biology Authors: Hengdao Liu,
Hong Xiang,
Shaoli Zhao,
Haiqiang Sang,
Fenghua Lv,
Ruifang Chen,
Zhihao Shu,
Alex F. Chen,
Shuhua Chen,
Hongwei Lu Tags: ORIGINAL ARTICLE Source Type: research
Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China
AbstractPoria cocos is an edible medicinal fungus known as “Fuling” in Chinese and has been used as a Chinese traditional medicine for more than two thousand years. Pharmacological studies reveal that polysaccharide is the most abundant substance inPoria cocos and has a wide range of biological activities including antitumour, immunomodulation, anti ‐inflammation, antioxidation, anti‐ageing, antihepatitis, antidiabetics and anti‐haemorrhagic fever effects. As a result, “Poria cocos polysaccharide oral solution ” was developed and sold as an over‐the‐counter health supplement since 1970s. In 2015, “Polys...
Source: Journal of Cellular and Molecular Medicine - November 15, 2018 Category: Molecular Biology Authors: Xiulian Li,
Yanli He,
Pengjiao Zeng,
Yong Liu,
Meng Zhang,
Cui Hao,
Hua Wang,
Zhihua Lv,
Lijuan Zhang Tags: REVIEW Source Type: research
MiR ‐130b promotes the progression of oesophageal squamous cell carcinoma by targeting SASH1
AbstractMiR ‐130b and SAM and SH3 domain containing 1 (SASH1) play an important role in many types of human cancers. The aim of our research was to study their interactions in the process of the proliferation and aggressiveness of oesophageal squamous cell carcinoma (ESCC) cells. Microarray analysis was done to screen the differentially expressed genes in the ESCC tissues. miR ‐130b andSASH1mRNA levels in the ESCC tissues and cells were detected by qRT ‐PCR. Dual luciferase reporter system was used to verify the target relationship between miR‐130b andSASH1. The effects of miR ‐130b onSASH1 expression were explor...
Source: Journal of Cellular and Molecular Medicine - November 15, 2018 Category: Molecular Biology Authors: Yuxing Zhu,
Yanni Ma,
Honghua Peng,
Lian Gong,
Mengqin Xiao,
Liang Xiang,
Dong He,
Ke Cao Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
Journal of Cellular and Molecular Medicine, Volume 22, Issue 12, Page 5765-5767, December 2018. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 15, 2018 Category: Molecular Biology Tags: ISSUE INFORMATION Source Type: research
Inhibiting the urokinase ‐type plasminogen activator receptor system recovers STZ‐induced diabetic nephropathy
AbstractThe urokinase ‐type plasminogen activator (uPA) receptor (uPAR) participates to the mechanisms causing renal damage in response to hyperglycaemia. The main function of uPAR in podocytes (as well as soluble uPAR ‐(s)uPAR‐ from circulation) is to regulate podocyte function through αvβ3 integrin/Rac‐1. We addressed the question of whether blocking the uPAR pathway with the small peptide UPARANT, which inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of streptozotocin (STZ)‐induced diabetes. The concentration of systemically administered UPARANT was meas...
Source: Journal of Cellular and Molecular Medicine - November 13, 2018 Category: Molecular Biology Authors: Massimo Dal Monte,
Maurizio Cammalleri,
Valeria Pecci,
Monica Carmosino,
Giuseppe Procino,
Alessandro Pini,
Mario De Rosa,
Vincenzo Pavone,
Maria Svelto,
Paola Bagnoli Tags: ORIGINAL ARTICLE Source Type: research
Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3
In conclusion, paroxetine is a potential therapeutic option for patients with colorectal cancer. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - November 13, 2018 Category: Molecular Biology Authors: Won ‐Jun Jang,
Sung Keun Jung,
Tam Thuy Lu Vo,
Chul‐Ho Jeong Tags: ORIGINAL ARTICLE Source Type: research
