Journal of Cardiovascular Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Cardiometabolic Consequences of Targeted Anticancer Therapies
Abstract: Cardiometabolic disease (CMD) is the most common preventable cause of death in the world. A number of components are included in the spectrum of CMD, such as metabolic syndrome/obesity, hyperglycemia/diabetes, dyslipidemia, and hypertension, which are independently associated with cardiovascular disease risk. These conditions often occur together, and patients with cancer frequently undergo treatments that can generate or worsen CMD. This review highlights and presents mechanistic and epidemiological evidence regarding CMD in 4 categories of anticancer medications, namely, mTOR/PI3K-Akt inhibitors, multitarge...
Source: Journal of Cardiovascular Pharmacology - October 1, 2022 Category: Cardiology Tags: Invited Review Article Source Type: research

Cardiotoxicity of Chemotherapeutic Drugs: An Update and Future Perspectives
This article provides an up-to-date review of the commonly used chemotherapeutic agents that cause cardiotoxicity and discusses current treatment options and evidence gaps. (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - October 1, 2022 Category: Cardiology Tags: Invited Review Article Source Type: research

Colchicine in Patients With STEMI: More Doubts Than Certainties
No abstract available (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - October 1, 2022 Category: Cardiology Tags: Commentary Source Type: research

Melatonin More Than Just a Sleeping Hormone
No abstract available (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - October 1, 2022 Category: Cardiology Tags: Commentary Source Type: research

Does Intensity Really Matter to Improve Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction?
No abstract available (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - October 1, 2022 Category: Cardiology Tags: Commentary Source Type: research

Cardiovascular Complications of Anticancer Therapy: A Developing Storm in Medicine
No abstract available (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - October 1, 2022 Category: Cardiology Tags: Editorial Source Type: research

Sacubitril/Valsartan Improves Sexual Function and Fibrosis of the Clitoral and Vaginal Tissues in Female Spontaneously Hypertensive Rats: Erratum
No abstract available (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Erratum Source Type: research

Efficacy and Underlying Mechanism of Berberine Against Atherosclerosis: A Meta-Analysis in Preclinical Animal Studies
Abstract: Atherosclerosis is the primary cause of many cardiovascular diseases, and an increasing number of studies have shown that berberine could delay plaque formation and development. Therefore, we aimed to evaluate its effects and explore its mechanisms in this meta-analysis. We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and VIP databases for original preclinical studies to conduct meta-analysis. Twelve articles (16 studies; 312 ApoE−/− mice) were included, and all the studies scored 3–5 points according to SYRCLE's risk of bias tool. Berberine could signific...
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Original Article Source Type: research

Impact of Initial Warfarin Dosing on Time in Therapeutic Range for Postoperative Left Ventricular Assist Device Patients
This study evaluated TTR after LVAD implantation compared between patients receiving low-dose ( (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Original Article Source Type: research

Aberrant Circulating SNHG1 Serves as a Biomarker to Distinguish Acute Myocardial Infarction and Construction of a Risk Model for Secondary Heart Failure
This study aimed to evaluate the clinical significance of long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) in the diagnosis and prognosis of AMI and to construct a logistic predict model to determine the risk of post-AMI HF. This study analyzed the data of 229 patients with AMI. Serum SNHG1 levels were examined using quantitative real-time PCR, and its diagnostic value was evaluated using receiver operating characteristic analysis. The predictive value of SNHG1 for HF onset was evaluated using the Kaplan–Meier method and Cox regression analysis. The risk factors and predictive parameters included in th...
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Original Article Source Type: research

Glucocorticoids Promote Na+ Excretion in the Renal Epithelia of Heart Failure Rats by Suppressing Transporter Proteins Involved in Acute Sodium Loading
Abstract: Glucocorticoid receptors are essential for normal development and stress responses. Their role in H2O and Na+ metabolism, especially in chronic heart failure (CHF), is not well defined. In a previous study, we found that glucocorticoids potentiate urination in CHF and promote H2O excretion by inhibiting the vasopressin receptor 2 pathway. The present study examines the effect of glucocorticoids on renal Na+ excretion and the underlying mechanisms in CHF rats with acute sodium loading. CHF was induced by left coronary artery ligation for 8 weeks. Rats were randomly assigned to 5 groups: control, CHF, dexametha...
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Original Article Source Type: research

Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats
This study aimed to explore whether vaspin could alleviate cardiac remodeling through attenuating oxidative stress in heart failure rats and to determine the associated signaling pathway. Cardiac remodeling was induced by myocardial infarction, transverse aortic constriction, or angiotensin (Ang) II infusion in vivo, and the neonatal rat cardiomyocytes (NRCMs) and neonatal rat cardiac fibroblasts (NRCFs) were treated with Ang II. Vaspin treatment alleviated fibrosis in myocardial infarction, transverse aortic constriction, and Ang II-treated rats. The Ang II-induced increases of atrial natriuretic peptide and brain natriur...
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Original Article Source Type: research

Transient Receptor Potential Vanilloid Type 1 Protects Against Pressure Overload–Induced Cardiac Hypertrophy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes
This study aimed to investigate whether TRPV1 activation improves the morphology and function of intracellular mitochondria to protect cardiomyocytes after pressure overload-induced myocardial hypertrophy. The myocardial hypertrophy model was established by performing transverse aortic constriction surgery in C57BL/6 J male mice. The data revealed that TRPV1 activation significantly reduced myocardial hypertrophy, promoted ejection fraction% and fractional shortening%, and decreased the left ventricular internal diameter in end-diastole and left ventricular internal diameter in end-systole after transverse aortic constrict...
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Original Article Source Type: research

Protective Effects and Mechanisms of Melatonin on Stress Myocardial Injury in Rats
In this study, we established a rat stress myocardial injury (SMI) model to explore the protective effect of melatonin (MLT) on SMI and its possible mechanisms of action. Adult female Sprague Dawley (SD) rats were randomly divided into 5 groups: blank control group (NC), SMI group, MLT low-dose group, MLT medium-dose group, and MLT high-dose group, and 10 rats in each group were used to establish a SMI model by the water immersion restraint method. We observed the changes in body weight and tail vein glucose of each group. Serum levels of corticosterone (Cort), creatine kinase isoenzyme (CK-MB), and Troponin Ⅰ (Tn-Ⅰ) a...
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Original Article Source Type: research

The Impaired Mechanism and Facilitated Therapies of Efferocytosis in Atherosclerosis
Abstract: Cardiovascular disease is responsible for the largest number of deaths worldwide, and atherosclerosis is the primary cause. Apoptotic cell accumulation in atherosclerotic plaques leads to necrotic core formation and plaque rupture. Emerging findings show that the progression of atherosclerosis appears to suppress the elimination of apoptotic cells. Mechanistically, the reduced edibility of apoptotic cells, insufficient phagocytic capacity of phagocytes, downregulation of bridging molecules, and dysfunction in the polarization of macrophages lead to impaired efferocytosis in atherosclerotic plaques. This revie...
Source: Journal of Cardiovascular Pharmacology - September 1, 2022 Category: Cardiology Tags: Review Article Source Type: research