Expression and clinicopathological correlation of Ki-67 in gallbladder carcinoma
CONCLUSIONS: Ki-67 is a marker of proliferation and it correlated with histological differentiation, jaundice and liver function tests, presence of stones, and location of metastases but did not correlate with stage and extent of disease.PMID:34729043 | PMC:PMC8511828 | DOI:10.4103/jcar.JCar_9_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Amit Gupta Sweety Gupta Deepak Rajput Prashant Durgapal Jaine John Chennatt Sanjeev Kishore Shalinee Rao Puneet Dhar Manoj Gupta Ravi Kant Source Type: research

Role of cancer stem cells in head-and-neck squamous cell carcinoma - A systematic review
J Carcinog. 2021 Sep 23;20:12. doi: 10.4103/jcar.JCar_14_20. eCollection 2021.ABSTRACTTargeting cancer stem cell (CSC) subpopulation within the tumor remains an obstacle for specific therapy in head-and-neck squamous cell carcinoma (HNSCC). Few studies in the literature describe a panel of stem cell makers, however a distinct panel has not been put forth. This systematic review aims to enhance the knowledge of additional markers to accurately relate their expression to tumorigenesis, metastasis, and therapy resistance. Databases, including PubMed, Google Scholar, Ebsco, and Science Direct, were searched from 2010 to 2017 u...
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Preeti Singh Dominic Augustine Roopa S Rao Shankargouda Patil Kamran Habib Awan Samudrala Venkatesiah Sowmya Vanishri C Haragannavar Kavitha Prasad Source Type: research

Evaluation and comparison of performance of low-dose 128-slice CT scanner with different mAs values: A phantom study
CONCLUSION: It is evident here that mAs has direct impact on the radiation dose to patient. With iDose4, mAs can be reduced to 50 mAs in multislice low-dose CT scan to reduce the radiation dose with minimal effect on image quality for slice thickness 4 mm. However, noise would dominate at tube current lower than 50 mAs for 120 kVp.PMID:34729045 | PMC:PMC8511832 | DOI:10.4103/jcar.JCar_25_20 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Shilpa Singh Rajesh Sukkala Source Type: research

Study of dosimetry and clinical factors for assessment of xerostomia in head and neck squamous cell carcinoma treated by intensity-modulated radiotherapy: A prospective study
CONCLUSION: Patients remained symptomatic for xerostomia chiefly till 6 months' postirradiation, but it was slightly relieved in 12 months but could not reach the baseline. Dosimetric sparing ofcontralateral parotid resulted in decreased probability of developing xerostomia.PMID:34729046 | PMC:PMC8511834 | DOI:10.4103/jcar.JCar_5_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Vrinda Singla Vipul Nautiyal Meenu Gupta Viney Kumar Shivani Mehra Mushtaq Ahmad Source Type: research

Serum ceruloplasmin as cancer marker in oral pre-cancers and cancers
CONCLUSIONS: The observations of the present study revealed that serum ceruloplasmin levels were found to be raised in all 3 study groups including oral leukoplakia, OSMF and OSCC as compared to the controls while the results were found to be statistically significant.PMID:34729047 | PMC:PMC8531576 | DOI:10.4103/jcar.jcar_10_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Manisha B Patil T Lavanya C Meena Kumari Shishir Ram Shetty Khalid Gufran Vipin Viswanath C Swarnalatha J Suresh Babu Abhishek Singh Nayyar Source Type: research

Assessment of correlation between clinical staging, functional staging, and histopathological grading of oral submucous fibrosis
This study assesses the correlation between clinical, functional, and histopathological grading of OSMF.AIM: To assess the correlation between clinical staging, functional staging, and histopathological grading of OSMF.MATERIALS AND METHODS: Thirty patients with clinical and histopathological diagnosis of OSMF were assigned into clinical stage, functional stage, and histopathological grade. The correlation between these three stages assigned was studied.STATISTICAL ANALYSIS: The degree of agreement between the clinical, functional, and histopathological classifications was quantified by the Weighted Kappa statistics. Corre...
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Anagha A Motgi Mrinal V Shete Mahesh S Chavan Nikkhiel N Diwaan Rashmi Sapkal Pallavi Channe Source Type: research

Molecular characterization of lung carcinomas: A study on diagnostic, predictive, and prognostic markers using immunohistochemical analysis at a Tertiary Care Center in Uttarakhand, India
CONCLUSION: SCC is the predominant histological subtype of NSCLC in the region of Uttarakhand, India, with a high proportion of cases harboring EGFR mutation. Variable expression of K-Ras, P-AKT, ALK 1, and PTEN in NSCLC signifies that molecular profile of every case is individualistic and independent. We attribute this to ethnicity, influence of implicated substance or metabolite in tobacco, and variable mutations incurred in tumor cells over a period of time.PMID:34729049 | PMC:PMC8531572 | DOI:10.4103/jcar.jcar_14_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Shalinee Rao Michael Leonard Anthony Nilotpal Chowdhury Rajesh Kathrotia Mayank Mishra Manisha Naithani Girish Sindhwani Neha Singh Source Type: research

Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome
CONCLUSIONS: Overall, hamsters may provide insights into how TP53 deficiency leads to cancer in humans and can become a new model to test novel therapies.PMID:34729050 | PMC:PMC8531574 | DOI:10.4103/jcar.jcar_18_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Jinxin Miao Rong Li Arnaud J Van Wettere Haoran Guo Alexandru-Flaviu Tabaran M Gerald O'Sullivan Timothy Carlson Patricia M Scott Kuisheng Chen Dongling Gao Huixiang Li Yaohe Wang Zhongde Wang Robert T Cormier Source Type: research

Outcome of routine histopathological examination of gallbladder specimen following elective laparoscopic cholecystectomy
CONCLUSION: Chronic calculus cholecystitis was the most common gall bladder disease with high female preponderance to all GB pathologies. This study affirms the importance of routine HPE after cholecystectomy as early incidental detection of carcinoma gall bladder alters the postoperative management approach and patients are expected to have a better outcome with it.PMID:34729051 | PMC:PMC8531575 | DOI:10.4103/jcar.jcar_19_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Ashesh Kumar Jha Ashraf Ali Manoj Kumar Manoj Kumar Punam Prasad Bhadani Niroop B S Murthy Kumar Chandrakant Source Type: research

Molecular classification and stratification of adult diffuse gliomas: A tertiary care center study
CONCLUSION: The results of the present study indicate that IHC including IDH1/2, ATRX, and p53 is useful for the molecular classification of diffuse gliomas, which could be useful for the evaluation of prognosis, especially Grade III and II. Although the immunohistochemical approach does not replace genetic testing completely, it is a practical and powerful means of assessing molecular genetic changes. IDH mutations are the established markers of better prognosis in diffuse gliomas.PMID:34729052 | PMC:PMC8531577 | DOI:10.4103/jcar.jcar_17_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Nidhi Anand Nuzhat Husain Renu Varshney Kiran Preet Malhotra Mohammad Kaif Source Type: research

Downregulation of Src-family tyrosine kinases by Srcasm and c-Cbl: A comparative analysis
CONCLUSION: Given the rarity of activating SFK mutations in human cancer, these data indicate that decreasing Srcasm level/function may represent a mechanism for increasing SFK activity in SCC and other human tumors.PMID:34729053 | PMC:PMC8531571 | DOI:10.4103/jcar.jcar_13_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Vivian Lee Thomas D Griffin Yoko Suzuki-Horiuchi Lily Wushanley Yerin Kweon Christine Marshall Weijie Li Elias Ayli Adele Haimovic Aliya Hines John T Seykora Source Type: research

Expression and clinicopathological correlation of Ki-67 in gallbladder carcinoma
CONCLUSIONS: Ki-67 is a marker of proliferation and it correlated with histological differentiation, jaundice and liver function tests, presence of stones, and location of metastases but did not correlate with stage and extent of disease.PMID:34729043 | PMC:PMC8511828 | DOI:10.4103/jcar.JCar_9_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Amit Gupta Sweety Gupta Deepak Rajput Prashant Durgapal Jaine John Chennatt Sanjeev Kishore Shalinee Rao Puneet Dhar Manoj Gupta Ravi Kant Source Type: research

Role of cancer stem cells in head-and-neck squamous cell carcinoma - A systematic review
J Carcinog. 2021 Sep 23;20:12. doi: 10.4103/jcar.JCar_14_20. eCollection 2021.ABSTRACTTargeting cancer stem cell (CSC) subpopulation within the tumor remains an obstacle for specific therapy in head-and-neck squamous cell carcinoma (HNSCC). Few studies in the literature describe a panel of stem cell makers, however a distinct panel has not been put forth. This systematic review aims to enhance the knowledge of additional markers to accurately relate their expression to tumorigenesis, metastasis, and therapy resistance. Databases, including PubMed, Google Scholar, Ebsco, and Science Direct, were searched from 2010 to 2017 u...
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Preeti Singh Dominic Augustine Roopa S Rao Shankargouda Patil Kamran Habib Awan Samudrala Venkatesiah Sowmya Vanishri C Haragannavar Kavitha Prasad Source Type: research

Evaluation and comparison of performance of low-dose 128-slice CT scanner with different mAs values: A phantom study
CONCLUSION: It is evident here that mAs has direct impact on the radiation dose to patient. With iDose4, mAs can be reduced to 50 mAs in multislice low-dose CT scan to reduce the radiation dose with minimal effect on image quality for slice thickness 4 mm. However, noise would dominate at tube current lower than 50 mAs for 120 kVp.PMID:34729045 | PMC:PMC8511832 | DOI:10.4103/jcar.JCar_25_20 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Shilpa Singh Rajesh Sukkala Source Type: research

Study of dosimetry and clinical factors for assessment of xerostomia in head and neck squamous cell carcinoma treated by intensity-modulated radiotherapy: A prospective study
CONCLUSION: Patients remained symptomatic for xerostomia chiefly till 6 months' postirradiation, but it was slightly relieved in 12 months but could not reach the baseline. Dosimetric sparing ofcontralateral parotid resulted in decreased probability of developing xerostomia.PMID:34729046 | PMC:PMC8511834 | DOI:10.4103/jcar.JCar_5_21 (Source: Journal of Carcinogenesis)
Source: Journal of Carcinogenesis - November 3, 2021 Category: Cancer & Oncology Authors: Vrinda Singla Vipul Nautiyal Meenu Gupta Viney Kumar Shivani Mehra Mushtaq Ahmad Source Type: research