Tumoral Pyruvate Kinase L/R as a Predictive Marker for the Treatment of Renal Cancer Patients with Sunitinib and Sorafenib
Conclusions: In this real world study we show that tumoral PKLR membrane expression is a positive predictive biomarker for sunitinib and sorafenib treatment in patients suffering from mRCC. Our results also indicate that the combined expression with cubilin more accurately than PKLR alone can select patients with no benefit from treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Marjut Niinivirta, Gunilla Enblad, Cecilia Lindskog, Fredrik Pont é n, Anca Dragomir, Gustav J. Ullenhag Tags: Research Paper Source Type: research

The mediating role of extent of resection in the relationship between the tumor characteristics and survival outcome of glioma
Conclusion: This study provides a better understanding of the process through which tumor characteristics is associated with hazard of death from glioma. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wang Juan, Chen Yin-Sheng, Jiang Xiao-Bing, Lin Fu-Hua, Chen Zheng-He, Wang Jian, Zhu Wei-Heng Tags: Research Paper Source Type: research

High numbers of CD163+ tumor-associated macrophages correlate with poor prognosis in multiple myeloma patients receiving bortezomib-based regimens
The prognostic significance of tumor-associated macrophages (TAMs) in multiple myeloma (MM) in the era of novel drugs remains unclear. CD163 expression was detected by immunohistochemistry to determine the number of TAMs in 198 MM patients receiving bortezomib-based regimens and the data were used to evaluate its relevance with clinical characteristics, treatment response, and prognosis. Patients with high levels of infiltrated CD163+ TAMs (>55/HPF) at diagnosis tended to have more adverse clinical characteristics. Patients with high CD163+ TAM content (>55/HPF) at diagnosis had worse progression-free survival (PFS) (P
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hua Wang, Wan-ming Hu, Zhong-jun Xia, Yang Liang, Yue Lu, Shu-xia Lin, Hailin Tang Tags: Research Paper Source Type: research

A Nomogram for Prediction of Overall Survival in Patients with Node-negative Gallbladder Cancer
Conclusion: This nomogram can be used as a decision model to predict the outcomes of postoperative overall survival for node-negative gallbladder cancer, and may give useful guidance to clinicians for next treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mingyu Chen, Jiasheng Cao, Bin Zhang, Long Pan, Xiujun Cai Tags: Research Paper Source Type: research

Analysis of the perceptions and attitudes to participate in radical and palliative clinical trials among Chinese lymphoma and head/neck cancer patients
This study included lymphoma patients who were enrolled into a radical treatment clinical trial, and head/neck cancer patients participating in a palliative clinical trial.Results: There were 136 lymphoma patients and 87 head/neck cancer patients who completed and returned the questionnaire. The questionnaire return rate was 100%. More than 90% of the patients in both groups showed trust and acceptance for medical care personnel, and more than 50% of the patients in both groups were in hope of trying new medication, receiving free medication, and receiving new treatment at an earlier rate. As compared with those in the rad...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qiu-Huan Kong, Lu-Ping Yang, Yue-Rong Lai, Hui-Ying Qin, Lian-Zhu He, Yu-Shan Liu, Yan-Er Li, Xiu-Jin Chen, Miao-Zhen Qiu, Zi-Xian Wang, Yu Wang Tags: Research Paper Source Type: research

Urovysion FISH Could Be Effective and Useful Method to Confirm the Identity of Cultured Circulating Tumor Cells from Bladder Cancer Patients
Conclusion: Application of FISH Urovysion to cultured CTCs from bladder cancer could be an effective first step to confirm their origin and sharing of chromosomal abnormalities (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Tae-Jung Kim, Hyong Woo Moon, Sungmin Kang, Jonghyup Yang, Sung-Hoo Hong, Ji Youl Lee, U-syn Ha Tags: Research Paper Source Type: research

Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma
Objective: The goal of our study is to identify a competing endogenous RNA (ceRNA) network using dysregulated RNAs between HCC tumors and the adjacent normal liver tissues from The Cancer Genome Atlas (TCGA) datasets, and to investigate underlying prognostic indicators in hepatocellular carcinoma (HCC) patients.Methods: All of the RNA- and miRNA-sequencing datasets of HCC were obtained from TCGA, and dysregulated RNAs between HCC tumors and the adjacent normal liver tissues were investigated by DESeq and edgeR algorithm. Survival analysis was used to confirm underlying prognostic indicators.Results: In the present study, w...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiwen Liao, Xiangkun Wang, Ketuan Huang, Chuangye Han, Jianlong Deng, Tingdong Yu, Chengkun Yang, Rui Huang, Xiaoguang Liu, Long Yu, Guangzhi Zhu, Hao Su, Wei Qin, Xianmin Zeng, Bowen Han, Quanfa Han, Zhengqian Liu, Xin Zhou, Yizhen Gong, Zhengtao Liu, Ji Tags: Research Paper Source Type: research

Risk Factors Associated with Precancerous Lesions of Esophageal Squamous Cell Carcinoma: a Screening Study in a High Risk Chinese Population
Conclusion: In Feicheng population, tobacco smoking or alcohol consumption may not be risk factors of EPLs. Low-quality drinking water raised the EPLs risk. Bad house heating materials, such as cereal straw, may lead to high EPLs risk. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yawen Sun, Tao Zhang, Wenjie Wu, Deli Zhao, Nan Zhang, Yongchun Cui, Yanxun Liu, Jianhua Gu, Peipei Lu, Fuzhong Xue, Jinming Yu, Jialin Wang Tags: Research Paper Source Type: research

A Propensity Score-adjusted Analysis of the Effects of Ubiquitin E3 Ligase Copy Number Variation in Peripheral Blood Leukocytes on Colorectal Cancer Risk
Conclusions: MDM2 amplification and SKP2 CNVs are associated with increased and decreased CRC risk, respectively; abnormal CNV-integrated model is more precise for predicting CRC risk. Further studies are needed to verify these encouraging outcomes. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Haoran Bi, Yupeng Liu, Tian Tian, Tingting Xia, Rui Pu, Yiwei Zhang, Fulan Hu, Yashuang Zhao Tags: Research Paper Source Type: research

Ellagic acid exerts antitumor effects via the PI3K signaling pathway in endometrial cancer
Ellagic acid (EA) is a polyphenol found in several fruits and plants. EA has been reported to exert antitumor activity in many types of cancers. However, the effect and potential molecular mechanism of EA in endometrial cancer are still unclear. Therefore, the aim of this study was to explore the underlying antitumor function and targets by which EA inhibits endometrial cancer. By using multiplatform bioinformatics analysis tools, including DrugBank, STRING, WebGestalt and cBioPortal, the core targets of EA were identified as PIK3CA and PIK3R1. In addition, through transwell assays, EA was strongly found to inhibit cell in...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yizi Wang, Fang Ren, Bo Li, Zixuan Song, Peng Chen, Ling Ouyang Tags: Research Paper Source Type: research

Carbon Ion Radiotherapy for Patients with Extracranial Chordoma or Chondrosarcoma - Initial Experience from Shanghai Proton and Heavy Ion Center
Conclusion: The results of this retrospective study are encouraging. Patients with extracranial chordoma or chondrosarcoma treated by CIRT in our center achieved a favorable shot-term outcome, without developing severe acute or late adverse events. The long-term results deserve further investigation, even in a prospective randomized trial. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shuang Wu, Ping Li, Xin Cai, Zhengshan Hong, Zhan Yu, Qing Zhang, Shen Fu Tags: Research Paper Source Type: research

Molecular Decision Tree Algorithms Predict Individual Recurrence Pattern for Locally Advanced Nasopharyngeal Carcinoma
Background: Recurrence remains one of the key reasons of relapse after the radical radiation for locally advanced nasopharyngeal carcinoma (NPC). Here, the multiple molecular and clinical variables integrated decision tree algorithms were designed to predict individual recurrence patterns (with VS without recurrence) for locally advanced NPC.Methods: A total of 136 locally advanced NPC patients retrieved from a randomized controlled phase III trial, were included. For each patient, the expression levels of 33 clinicopathological biomarkers in tumor specimen, 3 Epstein-Barr virus related serological antibody titer and 5 cli...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hongmin Cai, Xiaolin Pang, Dong Dong, Yan Ma, Yan Huang, Xinjuan Fan, Peihuang Wu, Haiyang Chen, Fang He, Yikan Cheng, Shuai Liu, Yizhen Yu, Minghuang Hong, Jian Xiao, Xiangbo Wan, Yanchun Lv, Jian Zheng Tags: Research Paper Source Type: research

High GCLC level in tumor tissues is associated with poor prognosis of hepatocellular carcinoma after curative resection
Glutamate-cysteine ligase catalytic subunit (GCLC) has been reported to overexpress in a variety types of cancer and be related with tumor progression and drug resistance. However, little has been known about GCLC's prognostic significance and biological roles in hepatocellular carcinoma (HCC). In the present study, we evaluated GCLC expression level using immunohistochemical staining (IHC) in tissue microarray (TMA) containing paired tumor and peritumoral liver tissues from 168 patients with HCC who received curative resection. GCLC levels in tumor tissues were significantly higher than in peritumoral liver tissues, and t...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jialei Sun, Chenhao Zhou, Qianni Ma, Wanyong Chen, Manar Atyah, Yirui Yin, Peiyao Fu, Shuang Liu, Bo Hu, Ning Ren, Haijun Zhou Tags: Research Paper Source Type: research

Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium
Inflammatory breast cancer (IBC) is an understudied and aggressive form of breast cancer with a poor prognosis, accounting for 2-6% of new breast cancer diagnoses but 10% of all breast cancer-related deaths in the United States. Currently there are no therapeutic regimens developed specifically for IBC, and it is critical to recognize that all aspects of treating IBC - including staging, diagnosis, and therapy - are vastly different than other breast cancers. In December 2014, under the umbrella of an interdisciplinary initiative supported by the Duke School of Medicine, researchers, clinicians, research administrators, an...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Gayathri R. Devi, Holly Hough, Nadine Barrett, Massimo Cristofanilli, Beth Overmoyer, Neil Spector, Naoto Ueno, Wendy Woodward, John Kirkpatrick, Benjamin Vincent, Kevin P. Williams, Charlotte Finley, Brandi Duff, Valarie Worthy, Shannon McCall, Beth A. H Tags: Review Source Type: research

Low-Grade Endometrial Stromal Sarcoma and Uterine Adenosarcoma: A Comparison of Clinical Manifestations and Outcomes
Conclusion: The patients with advanced LG-ESS had poor prognosis. Age and history of uterine leiomyoma were associated with poor PFS, while menopause and hormone therapy were protective factors associated with improved PFS in patients with LG-ESS. Peritoneal lavage cytology and radiotherapy did not improve prognosis of uterine adenosarcoma. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yanyan Zhang, Yan Li, Huifang Huang, Jiaxin Yang, Ming Wu, Ying Jin, Lingya Pan Tags: Research Paper Source Type: research

Circular RNA Signature in Hepatocellular Carcinoma
This study aimed to explore the significance of circRNAs in HCC progression. HCC-associated circRNA expression profiles GSE94508 and GSE97332 were downloaded from the Gene Expression Omnibus database (GEO), and 87 differentially expressed circRNAs (DECs) between HCC tissues and paired non-cancer tissues were identified, including 76 up-regulated and 11 down-regulated circRNAs. Gene ontolog (GO) and pathway analyses of the host genes of these DECs suggested that these host genes were enriched in cell adhesion, cytosol, and protein binding, and were associated with tight junction and Wnt signaling pathways. CircRNA-miRNA int...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lipeng Qiu, Tao Wang, Qi Ge, Han Xu, Yihang Wu, Qi Tang, Keping Chen Tags: Research Paper Source Type: research

Expression of NDRG2 in Human Colorectal Cancer and its Association with Prognosis
Objective: As a member of the N-myc downregulated gene family, N-Myc downstream-regulated gene 2 (NDRG2) contributes to tumorigenesis of various types of cancer. The expression status of NDRG2 in colorectal cancer (CRC) and its prognostic value remain to be elucidated. The goal of this study was to determine the expression pattern of NDRG2 in human CRC and its association of NDRG2 expression with prognosis.Methods: Immunohistochemistry was used to determine the level of NDRG2 expressions in 316 CRC tissues. The medical records of consecutive CRC patients undergoing primary tumor resection from September 2000 to February 20...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wenjing Chen, Jianhong Peng, Qingjian Ou, Yongshan Wen, Wu Jiang, Yuxiang Deng, Yujie Zhao, Desen Wan, Zhizhong Pan, Yujing Fang Tags: Research Paper Source Type: research

Asymmetric Division Gene Neurl2 Mediates Twist2 Regulation of Self-Renewal of Mouse Lewis Lung Cancer Stem Cells
Cancer stem cells (CSCs) play an important role in tumor development. While Epithelial-Mesenchymal Transition (EMT) has been shown to promote CSC self-renewal, underlying mechanisms are unclear. Here we identified and characterized the requirement of twist2, the EMT transcription factor, for the regulation of self-renewal thus stemness of mouse Lewis lung CSCs both in vitro and in vivo. Further, we elucidated the role of neurl2, an asymmetric division gene for normal stem cells, in mediating the self-renewal promoting activity of twist2. Moreover, analysis of TCGA showed a positive correlation between the expression of twi...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Doudou Liu, H. Rosie Xing, Yongli Liu, Zhiwei Sun, Ting Ye, Jingyuan Li, Jianyu Wang Tags: Research Paper Source Type: research

Overexpression of miR-15b Promotes Resistance to Sunitinib in Renal Cell Carcinoma
Conclusion: We here show miR-15b as a possible culprit for sunitinib resistance in ccRCC. Targeting miR-15b could potentially overcome drug resistance and related mechanism warrants further investigation. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lu Lu, Yanmin Li, Hui Wen, Chenchen Feng Tags: Research Paper Source Type: research

Adjustment of Microvessel Area by Stromal Area to Improve Survival Prediction in Non-Small Cell Lung Cancer
Conclusions: Our study showed that the NSCLC patients with high SnMVA had higher OS. And SnMVA is a prognostic factor with greater accuracy than MVA. Since stroma exists widely in a variety of cancer tissues, we infer that SnMVA may also predict the prognostic of other types of cancers. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Luo Fang, Ying He, Yujia Liu, Haiying Ding, Yinghui Tong, Luying Hu, Canming Wang, Yiwen Zhang, Xiaowei Zheng, Ping Huang Tags: Research Paper Source Type: research

MiR-HCC2 Up-regulates BAMBI and ELMO1 Expression to Facilitate the Proliferation and EMT of Hepatocellular Carcinoma Cells
MicroRNAs (miRNAs) are a class of gene expression regulators that participate in the occurrence and development of hepatocellular carcinoma (HCC), although the underlying mechanism by which they function in HCC has not been fully elucidated. Here, small RNA deep sequencing was used to identify aberrantly expressed miRNAs in HCC tissues, and a novel miRNA named miR-HCC2 was identified. RT-qPCR analysis demonstrated that miR-HCC2 displayed higher expression in HCC tissues than in adjacent non-tumor tissues. We documented that miR-HCC2 facilitated the growth, migration and invasion of HCC cells by accelerating cell cycle prog...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jianying Yi, Yajie Fan, Le Zhang, Hong Wang, Ting Mu, Hong Xie, Huijie Gao, Min Liu, Shengping Li, Hua Tang Tags: Research Paper Source Type: research

Combination of PET and CXCR4-Targeted Peptide Molecule Agents for Noninvasive Tumor Monitoring
In conclusion, this study demonstrates that small molecule peptide agents can be used as an additional diagnostic tool for precision medicine. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yizi Lin, Yi Lin, Xiao Lin, Xiaotian Sun, Kun Luo Tags: Research Paper Source Type: research

Nuclear Nrf2 Activity in Laryngeal Carcinoma is Regulated by SENP3 After Cisplatin-Induced Reactive Oxygen Species Stress
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a nuclear transcription factor that is activated by reactive oxygen species (ROS). Recent studies reported that hyperactivation of the Nrf2 pathway creates an environment that favors the survival of normal as well as malignant cells, protecting them against oxidative stress, chemotherapeutic agents, and radiotherapy. SUMO1/sentrin/SMT3 specific peptidase 3 (SENP3) reverses sumoylation of small ubiquitin-like modifier (SUMO)-conjugates. We demonstrated that Nrf2 was detected in the nuclei of laryngeal carcinoma cells, but not in cells of tissues surrounding the cancer, w...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zheng Zhou, Ji Xu, Ximing Bao, Jiali Shi, Bin Liu, Yanqing Chen, Jiping Li Tags: Research Paper Source Type: research

Smoking Induced Extracellular Vesicles Release and Their Distinct Properties in Non-Small Cell Lung Cancer
In this study, we characterized smoking induced extracellular vesicles in smokers with non-small cell lung cancer (NSCLC).Methods: EVs were isolated from bronchoalveolar lavage (BAL) from smokers and NSCLC patients. EV microRNAs (miRNAs) were analyzed by using a TaqMan microRNA assays. Vesicle mRNAs and long non-coding RNAs (lncRNAs) were measured with quantitative RT-PCR. Tumor associated antigens were examined by Western Blot.Results: Higher levels of local site EVs are found in the lung of smokers and NSCLC patients. Further, over 90% of lung EVs are round vesicles of approximately 50-200 nm, ie., exosomes. There are 21...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Feng Wu, Zhongyuan Yin, Lin Yang, Jinshuo Fan, Juanjuan Xu, Yang Jin, Jizhang Yu, Dan Zhang, Guanghai Yang Tags: Research Paper Source Type: research

Association of the TP53 rs1042522 C > G polymorphism and hepatoblastoma risk in Chinese children
The TP53 gene encodes an important class of cell cycle and tumor-suppressing factors that play critical roles in maintaining genomic stability. The TP53 Arg72Pro (rs1042522 C>G) polymorphism has been reported to be associated with the risk of several types of adult cancers; however, its risk for pediatric cancers remains unclear. Here, we analyzed the association of the TP53 gene rs1042522 C>G polymorphism with hepatoblastoma (HB) susceptibility in a hospital-based study among Chinese children. A total of 213 HB patients and 958 healthy controls were enrolled in the study. Genotypes were determined by a TaqMan assay,...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Tianyou Yang, Yang Wen, Jiahao Li, Jiliang Yang, Tianbao Tan, Jing Pan, Chao Hu, Jiao Zhang, Yijuan Xin, Suhong Li, Huimin Xia, Jing He, Yan Zou Tags: Short Research Communication Source Type: research

Chronic hepatitis B virus infection is associated with a poorer prognosis in diffuse large B-cell lymphoma: a meta-analysis and systemic review
Accumulating evidence from clinical trials indicates chronic hepatitis B virus (HBV) infection is associated with the incidence of diffuse large B-cell lymphoma (DLBCL) and may be associated with the prognosis of DLBCL, though this suggestion remains controversial. We performed a meta-analysis to assess whether HBV infection is associated with prognosis and response to chemotherapy in DLBCL. After a strict literature search strategy, a total of 809 HBV surface antigen (HBsAg) seropositive patients with DLBCL and 2849 HBsAg seronegative patients with DLBCL from twelve trials were included. DLBCL patients with chronic HBV in...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xingyu Rong, Hai Wang, Jiexian Ma, Shaokun Pan, Huijing Wang, Sha Jing, Yu Su, Lancui Wang, Chao Zhao Tags: Research Paper Source Type: research

Role of Endometrial Autophagy in Physiological and Pathophysiological Processes
Endometrium is the mucosal lining of the uterus which expressed a cyclic process of proliferation, secretion and scaling under the control of hormones secreted by the ovary, and it also plays an indispensable role in the embryo implantation, the constitution of fetal-maternal interface, and the maintaining of pregnancy. In pathophysiological conditions, the abnormality or disorder of endometrium may lead to endometrium-related diseases, such as endometriosis, endometrium hyperplasia and even endometrial carcinoma. In recent years, more and more evidence revealed that autophagy exists in both the endometrium stroma cells an...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shaoliang Yang, Haiyan Wang, Dajin Li, Mingqing Li Tags: Review Source Type: research

Immunopotentiator Aikejia improves the therapeutic efficacy of PD-1/PD-L1 immunosuppressive pathway in CT26.WT cancer cell
Tumors can escape immunosurveillance through immunocheckpoint such as the PD-1/PD-L1 pathway. Aikejia comes from Nocardia rubra cell-wall skeleton and can increase the number of inflammatory factors and immune cells. In this work, we showed that the levels of PD-L1 increase in CT26.WT xenograft after subcutaneous injection of Aikejia in mice, but Aikejia did not induce the expression of PD-L1 in vitro. When we treated the mice with Aikejia and blocked PD-1/PD-L1 pathway in vivo at the same time, the CT26.WT xenografts were significantly inhibited or eliminated, which was better than single treatment alone. Our results sugg...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chaoqun Huang, Xiaoqiong Tang, Suhuan Li, Qingshui Wang, Bifeng Xie, Jing Xu, Yao Lin Tags: Research Paper Source Type: research

The use of ultrasonic scalpel lowers the risk of post-mastectomy seroma formation in obese women
Introduction: Seroma formation (SF) is the most common postoperative complication after mastectomy and axillary surgery. The aim of this study was to assess its incidence and risk factors following a modified radical mastectomy in breast cancer patients.Materials and methods: 271 patients who underwent a modified radical mastectomy (250 with traditional electrocautery and 21 with an ultrasonic scalpel) were studied. The SF rate was calculated and its association with patient-related factors, surgical features and postoperative variables was assessed and statistically analyzed with P
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Tomasz Michalik, Rafal Matkowski, Przemyslaw Biecek, Bartlomiej Szynglarewicz Tags: Research Paper Source Type: research

Real-World Data on Prognostic Factors for Overall Survival in EGFR-Mutant Non-Small-Cell Lung Cancer Patients with Brain Metastases
Background: With the wide application of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), the survival of EGFR-mutant non-small-cell lung cancer (NSCLC) patients with brain metastasis (BM) has been significantly improved. However, prognosis analysis for patients with EGFR mutation and BM is still lacking, and the prognostic factors remain to be determined.Materials and methods: A total of 746 NSCLC patients with BM were identified between January 2013 and December 2016 at our institution. Overall, 261 patients harboring EGFR mutation and meeting the inclusion criteria for the study were enrolled. Ex...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaoqing Yu, Yun Fan Tags: Research Paper Source Type: research

High preoperative serum globulin in hepatocellular carcinoma is a risk factor for poor survival
This study was performed to evaluate whether GLB analysis could be applied for the prediction of the prognosis of patients received liver resection.Methods: A training cohort study involving 210 HCC patients undergoing curative liver resection between January 2007 and December 2012, and a validation cohort involving 100 HCC patients contemporaneously undergoing curative liver resection in another set were recruited. The survival curves were graphed and log-rank test was performed to analyze the differences between the curves. The cutoff value was selected by X-title program.Results: Univariate and multivariate analysis ind...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wenjie Zhang, Guangyan Zhangyuan, Fei Wang, Haitian Zhang, Decai Yu, Jincheng Wang, Kangpeng Jin, Weiwei Yu, Yang Liu, Beicheng Sun Tags: Research Paper Source Type: research

KIAA0101 is a novel transcriptional target of FoxM1 and is involved in the regulation of hepatocellular carcinoma microvascular invasion by regulating epithelial-mesenchymal transition
In this study, weighted gene coexpression network analysis (WGCNA) was performed to jointly analyze clinical information and gene expression data to identify key genes associated with clinical features. Through the bioinformatic analysis, the yellow module and microvascular invasion (MVI) were found to be highly associated (r=0.41) by Pearson's correlation analysis, and 20 hub genes were identified with both high gene significance (GS) and high module membership (MM) in the yellow module. Among these genes, FoxM1 and KIAA0101 were upregulated in HCC with MVI and were significantly positively correlated in HCC samples, indi...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Tao Zhang, Jianrong Guo, Jian Gu, Ke Chen, Zheng Wang, Huili Li, Guobin Wang, Jiliang Wang Tags: Research Paper Source Type: research

Comparison of the MAID (AI) and CAV/IE regimens with the predictive value of cyclic AMP-responsive element-binding protein 3 like protein 1 (CREB3L1) in palliative chemotherapy for advanced soft-tissue sarcoma patients
Conclusions: Our study suggests that the CAV/IE alternating regimen may be associated with a better response and more favorable survival than the MAID (AI) regimen in advanced soft-tissue sarcoma patients. Furthermore, the CREB3L1 expression level may predict the efficacy and survival of doxorubicin-based palliative chemotherapy for advanced soft-tissue sarcoma. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wei Xiao, Yao Liang, Yi Que, Jingjing Li, Ruiqing Peng, Bushu Xu, Xizhi Wen, Jingjing Zhao, Yuanxiang Guan, Xing Zhang Tags: Research Paper Source Type: research

Preoperative Immune Response is Associated with Perioperative Transfusion Requirements in Glioma Surgery
Immunosuppression induced by transfusion causes postoperative adverse events including poor prognosis in cancer, but data on influence of the immune response on blood transfusion requirements during perioperative period are limited. The aim of this study was to investigate whether the preoperative immune response is associated with perioperative blood cell transfusion in a glioma surgical patient population. The authors identified 321 cases of surgery for treatment of glioma. Patient variables, preoperative laboratory variables (hemoglobin, platelet count, activated partial thromboplastin time, prothrombin time, hematocrit...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Zhang, Huahui Wu, Jingjun Zhang, Qi Qi, Wei Zhang, Rong Xia Tags: Research Paper Source Type: research

HCCR-1 is a Novel Prognostic Indicator for Gastric Cancer and Promotes Cell Proliferation
In conclusion, HCCR-1 is a gastric cancer oncogene, and its increased expression plays a critical role in the occurrence and development of gastric cancer. Hence, HCCR-1 could serve as a valuable marker for the postoperative prognostic assessment of gastric cancer patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Liang-Fei Zhu, Peng Ma, Yi-Lin Hu, Ying Feng, Peng Li, Hua Wang, Yi-Bing Guo, Qin-Sheng Mao, Wan-Jiang Xue Tags: Research Paper Source Type: research

Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma
Purpose: Aldo-keto reductase family 1, member C2 (AKR1C2) gene encodes for a member of the AKR superfamily and participates in the metabolism of various drugs. Moreover, tumor and normal tissues exhibit an evident difference in the expression level of this gene.Methods: We downloaded and analyzed AKR1C2 expression level and the data consisting of the clinicopathological features of 490 papillary thyroid carcinoma (PTC) tumor tissues and 59 normal thyroid tissues from The Cancer Genome Atlas (TCGA) cohort. Diverse statistical methods, such Chi-square test, univariate and multivariate Cox regression analyses, and Kaplan-Meie...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yi-Xiang Jin, Xiao-fen Zhou, Ying-ying Chen, Wen-xu Jin, Ying-hao Wang, Dan-rong Ye, Yi-han Sun, Yue-feng Li, Qing-xuan Wang, Xiao-Hua Zhang, Ou-Chen Wang, En-Dong Chen Tags: Research Paper Source Type: research

Lung cancer in young adults aged 35 years or younger: A full-scale analysis and review
Conclusions: Lung cancer in young adults is distinctive, with adenocarcinoma and stage IV at presentation being predominant characteristics. Gene mutation assessment should be mandatory in this subgroup due to the increased likelihood of positive driver gene alterations, as individualized targeted therapy may achieve superior outcomes. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bailong Liu, Xiaoyue Quan, Changgen Xu, Jincai Lv, Cheng Li, Lihua Dong, Min Liu Tags: Review Source Type: research

MiR-506 Suppresses Colorectal Cancer Development by Inhibiting Orphan Nuclear Receptor NR4A1 Expression
In conclusion, miR-506 acts as a tumor suppressor and inhibits proliferation, migration and invasion in colorectal cancer cells partly through decreasing NR4A1 expression. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Meihui Huang, Xina Xie, Xuhong Song, Songgang Gu, Xiaolan Chang, Ting Su, Bin Liang, Dongyang Huang Tags: Research Paper Source Type: research

LncRNA SNHG16 Promotes Hepatocellular Carcinoma Proliferation, Migration and Invasion by Regulating miR-186 Expression
Long non-coding RNA (lncRNA) and microRNA (miRNA) play an important role in genesis and progression of tumors. The aim of this study was to explore the expression, biological function and molecular mechanism of small nucleolar RNA host gene 16 (SNHG16) in HCC. RT-qPCR was conducted to evaluate the expression level of SNHG16 in HCC tissues and cell lines. Our findings showed for the first time that SNHG16 was up-regulated in HCC tissues and cell lines. The expression of SNHG16 in cancer tissues was highly correlated with tumor size, TNM stage, ALT expression level and HBV DNA level. Moreover, cell proliferation, migration a...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hang Chen, Molin Li, Ping Huang Tags: Research Paper Source Type: research

EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy
Cutaneous melanoma is one of the most common malignant skin tumors and advanced melanoma is usually associated with a poor prognosis. In the current study, we demonstrated the tumor suppressing role of epithelial membrane protein-2 (EMP2) by inducing apoptosis in a A375 human melanoma cell line. Mechanistically, the low expression of EMP2 in melanoma is partially due to autophagic protein degradation mediated by the mTOR pathway. These results suggest there is regulation of autophagy as well as EMP2 levels might be an interesting novel targeted therapeutic strategy for melanoma. Although the further investigation is needed...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Manyi Wang, Sijia Li, Peng Zhang, Yujia Wang, Chunting Wang, Ding Bai, Xian Jiang Tags: Research Paper Source Type: research

Associations of mRNA expression of DNA repair genes and genetic polymorphisms with cancer risk: a bioinformatics analysis and meta-analysis
A systematical bioinformatics and meta-analysis were carried out to establish our understanding of possible relationships between DNA repair genes and the development of cancer. The bioinformatics analysis confirmed that lower XPA and XPC levels and higher XPD, XPF, and WRN levels were observed in 19 types of cancer, and subsequently results indicated that elevated XPA and XPC had a better impact on overall survival, however, higher XPD, XPF, and WRN showed worse influence on cancer prognosis. The meta-analysis included 58 eligible studies demonstrated that harboring XPA rs10817938, XPD rs238406 increased overall cancer ri...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Huizhe Wu, Shanqiong Li, Xiaoyun Hu, Wenyan Qin, Yilin Wang, Tong Sun, Zhikun Wu, Xiufang Wang, Senxu Lu, Dongping Xu, Yalun Li, Shu Guan, Haishan Zhao, Weifan Yao, Mingyan Liu, Minjie Wei Tags: Review Source Type: research

AC138128.1 an Intronic lncRNA originating from ERCC1 Implies a Potential Application in Lung Cancer Treatment
Lung cancer is one of the most devastating tumors with a high incidence and mortality worldwide. Polymorphisms and expression of ERCC1 commonly predicted the occurrence and prognosis of lung cancer. However, few studies have focused on long non-coding RNAs related to ERCC1 though some studies reminded the importance of its post-transcriptional regulation. In the present study, an intronic lncRNA AC138128.1 originated from ERCC1 was firstly identified in microarray chip and database, and its possibility as a novel biomarker to predict lung cancer treatment was further discussed. Firstly, the qRT-PCR data showed that AC13812...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mingyang Xiao, Su Cui, Liang Zhang, Tao Yu, Guopei Zhang, Qianye Zhang, Liuli Li, Yuan Cai, Cuihong Jin, Jinghua Yang, Shengwen Wu, Xiaobo Lu Tags: Research Paper Source Type: research

Association between Pretreatment Serum High-density Lipoprotein Cholesterol and Treatment Outcomes in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma Treated with Chemoradiotherapy: Findings from a Randomised Trial
Conclusions: The pretreatment serum level of HDL-C was an independent prognostic factor for patients with locoregionally advanced nasopharyngeal carcinoma who were treated with chemoradiotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Cheng-Tao Wang, Ming-Yuan Chen, Xiang Guo, Ling Guo, Hao-Yuan Mo, Chao-Nan Qian, Bi-Xiu Wen, Ming-Huang Hong, Pei-Yu Huang Tags: Research Paper Source Type: research

Validation study of susceptibility loci for esophageal squamous cell carcinoma identified by GWAS in a Han Chinese subgroup from Eastern China
Esophageal squamous cell carcinoma (ESCC) occurs at a relatively high frequency in China and is one of the most prevalent cancers in the world. Genome-wide association studies (GWAS) have identified 24 single-nucleotide polymorphisms (SNPs) that could be associated with ESCC in Chinese patients. This retrospective study aimed to validate the association between these 24 SNPs and ESCC in a Han Chinese subgroup from East China. A total of 2280 and 1900 patients with ESCC (case group) and non-esophageal cancer (control group) were included from a single center. Genotyping of the 24 polymorphisms was performed using the Sequen...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Kai-Lai Wang, Xiang-Liu Chen, Lan Lei, Pei Li, Lian-Lian Hong, Xian-Chong Huang, Wei-Min Mao, Kenichi Mukaisho, Zhi-Qiang Ling Tags: Research Paper Source Type: research

Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells
In this study, we showed that LKB1 overexpression could phosphorylate YAP and promoted its nuclear rejection. Silencing LKB1 could dephosphorylate YAP and promoted its entry into the nucleus. Here, we found that LKB1 inhibited the mRNA expression and the amplification of hTERC. YAP further up-regulated hTERC at mRNA and gene amplification levels. Therefore, we suggest that LKB1 may inhibit the expression and amplification of hTERC through the axis of LKB1-pYAP(YAP)-hTERC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ling He, Ming-Zhe Wu, Xu-Bo Wang, Xue-Shan Qiu, En-Hua Wang, Guang-Ping Wu Tags: Research Paper Source Type: research

Association between Polymorphisms of Vitamin D Receptor and Lung Cancer Susceptibility: Evidence from an Updated Meta-analysis
Conclusion: The results of this meta-analysis suggested that Bsm1, Taq1 and Cdx-2 polymorphism may contribute to lung cancer susceptibility, more studies need be conducted to confirm in the future. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Meng Li, Xinyu Liu, Na Liu, Tian Yang, Puyu Shi, Ruiqing He, Mingwei Chen Tags: Research Paper Source Type: research

Effect of Early Nutrition Intervention on Advanced Nasopharyngeal Carcinoma Patients Receiving Chemoradiotherapy
This study is to investigate the influence of early nutritional intervention on advanced NPC patients with CRT by evaluating the nutritional status and CRT treatment tolerance.Methods: A cohort of 78 stage III-IV nasopharyngeal carcinoma patients was divided into early (n=46) and late (n=32) nutrition intervention groups. The early group of patients received nutritional support at the beginning of CRT, whereas the late group received such a support until development of the side effects, like 50% required oral dietary intake or>10% weight loss. The data were collected and statistically analyzed.Results: There was no sign...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lingbin Meng, Jinlong Wei, Rui Ji, Bin Wang, Xiaochun Xu, Ying Xin, Xin Jiang Tags: Research Paper Source Type: research

Pre-treatment Serum Lactate Dehydrogenase Predicts Distant Metastasis and Poor Survival in Nasopharyngeal Carcinoma
Conclusions: Pre-treatment serum LDH level can predict distant metastasis and associate with the poor survival in patients with NPC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guoxian Long, Wenhua Tang, Xiugen Fu, DongBo Liu, LinLi Zhang, Guangyuan Hu, Guoqing Hu, Wei Sun Tags: Research Paper Source Type: research

A medicinal and edible formula YH0618 ameliorates the toxicity induced by Doxorubicin via regulating the expression of Bax/Bcl-2 and FOXO4
This study was to investigate the role and mechanism of YH0618 in ameliorating DOX-induced toxicity by in vitro and in vivo experiments. YH0618 selectively attenuated DOX-induced growth inhibition and apoptosis in human normal liver L02 cells and kidney HEK-293 cells, and simultaneously potentiated the anti-cancer effect of DOX in breast cancer MCF-7 and MDA-MB-231 cells by apoptosis pathways. Western blotting results revealed that YH0618 attenuated DOX-induced apoptosis in normal liver and kidney cells through FOXO4-mediated mitochondria-dependent mechanism. Animal experiments demonstrated that, YH0618 did not interfere i...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jieshu You, Fei Gao, Hailin Tang, Fu Peng, Lei Jia, Kun Huang, Kinlong Chow, Jiaqi Zhao, Huanlan Liu, Yi Lin, Jianping Chen Tags: Research Paper Source Type: research

Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer
Chaetocin, a natural product extracted from Chaetomium species, possesses anticancer effects in several kinds of tumors. However, it remains unclear whether the potential indication for chaetocin could also include human gastric cancer. We found here that chaetocin induced caspase-dependent and -independent apoptosis in human gastric cancer cell lines, which greatly depended on BID-mediated AIF translocation. Despite not increasing the intercellular ROS levels in gastric cancer cells, chaetocin did cause a reduction in mitochondrial membrane potential probably through its regulation on the expression of Bcl-2 and BAX. Chae...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xinwen Liao, Yaqiong Fan, Jihuan Hou, Xiong Chen, Xiaolin Xu, Yifan Yang, Jinying Shen, Panying Mi, Xiaohua Huang, Wenqing Zhang, Hanwei Cao, Xiaoting Hong, Tianhui Hu, Yan-yan Zhan Tags: Research Paper Source Type: research