Circular RNA hsa_circ_0000700 promotes cell proliferation and migration in Esophageal Squamous Cell Carcinoma by sponging miR-1229
Accumulating evidence has demonstrated that circular RNAs (circRNAs) are involved in the pathogenesis of cancer, including that of esophageal squamous cell carcinoma (ESCC). The current study aimed to investigate the role of hsa_circ_0000700 in ESCC. hsa_circ_0000700, miR-1229, and related functional gene expression was measured by RT-qPCR. To characterize the functions of hsa_circ_0000700 and miR-1229, ESCC cells were infected with hsa_circ_0000700-specific siRNA, miR-1229 mimics, and an inhibitor alone or in combination. Cell Counting Kit-8 (CCK8), colony formation, EdU, flow cytometry, and Transwell assays were employed...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jun Fang, Wen Hao Ji, Fang Zheng Wang, Tie Ming Xie, Lei Wang, Zhen Fu Fu, Zhun Wang, Feng Qin Yan, Qi Liang Shen, Zhi Min Ye Tags: Research Paper Source Type: research
Region-specific Risk Factors for Pelvic Lymph Node Metastasis in Patients with Stage IB1 Cervical Cancer
Conclusions: Tumour size, LVSI and age are region-specific risk factors for pelvic LNM in IB1 cervical cancer, which could be used to allocate the appropriate extent of pelvic lymphadenectomy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jing Zhao, Jing Cai, Hongbo Wang, Weihong Dong, Yuan Zhang, Shaohai Wang, Xiaoqi He, Si Sun, Yuhui Huang, Bangxing Huang, Kay C. Willborn, Ping Jiang, Zehua Wang Tags: Research Paper Source Type: research
Real-world data combined with studies on Regulatory B Cells for newly diagnosed Multiple Myeloma from a tertiary referral Hospital in South-Western China
This study found using bortezomib plus dexamethasone as backbone showed promising efficacy with acceptable tolerability in NDMM. The relatively compromised progression free survival (PFS) points to the essential synergy of bortezomib and lenalidomide here. This study also found that altered proportions of Bregs were closely correlated with treatment efficacy and prognosis in MM. Further understanding of Bregs biology might provide new opportunities to develop immunotherapy, which could prove beneficial in treating MM. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zhongqing Zou, Tingting Guo, Jian Cui, Wenjiao Tang, Yan Li, Fangfang Wang, Tian Dong, Yunfan Yang, Yan Feng, Matthew Ho, Li Zhang, Ling Pan, Ting Niu Tags: Research Paper Source Type: research
Bevacizumab Plays a double-edged role in Neoadjuvant Therapy for Non-metastatic Breast Cancer: A Systemic Review and Meta-Analysis
The anti-angiogenic drug Bevacizumab (Bev) is engaged in neoadjuvant therapy for non-metastatic breast cancer (NMBC). However, whether neoadjuvant Bev providing a greater benefit to patients is debatable. Our study aimed to review Bev's role in Neoadjuvant therapy (NAT) in NMBC and identify predictive markers associated with its efficacy by systemic review and meta-analysis. Eligible trials were retrieved from the Pubmed, Embase, and Cochrane Library, and random or fixed effects models were applied to synthesize data. Power of pCR to predict DFS or OS was evaluated by nonlinear mixed effect model. In NMBC, Bev significantl...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: XinJie Chen, Yu Gao, GanLin Zhang, BingXue Li, TingTing Ma, YunFei Ma, XiaoMin Wang Tags: Research Paper Source Type: research
Overexpression of Galectin10 Predicts a Better Prognosis in Human Ovarian Cancer
In conclusion, LGALS10 possibly is a valuable biomarker for predicting a favorable prognosis in patients with ovarian cancer, especially with serous, all stages and grade III cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wenxiao Jiang, Mandika Chetry, Shuya Pan, Longyi Wang, Xueqiong Zhu Tags: Research Paper Source Type: research
Methylated SFRP2 and SDC2 in stool specimens for Colorectal Cancer early detection: A cost-effective strategy for Chinese population
Conclusion: Combined detections of methylated SFRP2 and methylated SDC2 in stool samples demonstrated high sensitivities and specificity for the detection of AA and early stage CRC. Therefore, this combination has the potential to become an accurate and cost-effective tool for CRC early detection. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Guodong Zhao, Xiaoyu Liu, Yi Liu, Yong Ma, Jun Yang, Hui Li, Shangmin Xiong, Sujuan Fei, Minxue Zheng, Xiangwei Zhao Tags: Research Paper Source Type: research
Promoter hypermethylation of early B cell factor 1 (EBF1) is associated with cholangiocarcinoma progression
In this study, the DNA methylation status of EBF1 and mRNA expression levels were analyzed in CCA and normal bile duct (NBD) tissues using a publicly available database of genome-wide association data. The results showed that the DNA methylation of EBF1 promoter region was significantly increased in CCA tissues compared with those of NBD. The degree of methylation was negatively correlated with EBF1 mRNA expression levels. Using methylation-specific PCR technique, the DNA methylation rates of EBF1 promoter region were investigated in CCA tissues (n=72). CCA patients with high methylation rates of EBF1 promoter region in th...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Napat Armartmuntree, Apinya Jusakul, Chadamas Sakonsinsiri, Watcharin Loilome, Somchai Pinlaor, Piti Ungarreevittaya, Chern Han Yong, Anchalee Techasen, Kanokwan Imtawil, Ratthaphol Kraiklang, Nattawan Suwannakul, Waleeporn Kaewlert, Timpika Chaiprasert, Tags: Research Paper Source Type: research
Utility of Preoperative Inflammatory Markers to Distinguish Epithelial Ovarian Cancer from Benign Ovarian Masses
Conclusions: In addition to CA125, NLR, PLR, and LMR could be used as predictors of EOC and preoperative inflammatory markers may be used as a potential biomarker for predicting different histotypes of EOC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Lian Li, Jing Tian, Liwen Zhang, Luyang Liu, Chao Sheng, Yubei Huang, Hong Zheng, Fengju Song, Kexin Chen Tags: Research Paper Source Type: research
Serum Angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma
In conclusion, our findings indicate that serum Ang2 is a potential novel biomarker for both diagnosis and prognosis in HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Junjie Ao, Tetsuhiro Chiba, Hiroaki Kanzaki, Kengo Kanayama, Shuhei Shibata, Akane Kurosugi, Terunao Iwanaga, Motoyasu Kan, Takafumi Sakuma, Na Qiang, Yaojia Ma, Ryuta Kojima, Yuko Kusakabe, Masato Nakamura, Kazufumi Kobayashi, Soichiro Kiyono, Naoya Kano Tags: Research Paper Source Type: research
Identification and validation of the clinical roles of the VHL-related LncRNAs in clear cell renal cell carcinoma
In conclusion, our results demonstrated that lncRNA FGD5-AS1 was significantly associated with VHL and can serve as a novel biomarker of ccRCC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wuping Yang, Jingcheng Zhou, Kenan Zhang, Lei Li, Yawei Xu, Kaifang Ma, Haibiao Xie, Lin Cai, Yanqing Gong, Kan Gong Tags: Research Paper Source Type: research
Integrating pre- and post-treatment Plasma Epstein-Barr Virus DNA levels for better prognostic prediction of Nasopharyngeal Carcinoma
Conclusions: Integrating pre-EBV and 3 m-EBV data could provide more accurate risk stratification and better prognostic prediction in NPC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wanxia Li, Chao Yang, Zehong Lv, Junzheng Li, Zonghua Li, Xiaofei Yuan, Shuting Wu, Yue Yuan, Linchong Cui, Juan Lu, Jing Chen, Feipeng Zhao Tags: Research Paper Source Type: research
LINC01296/miR-141-3p/ZEB1-ZEB2 axis promotes tumor metastasis via enhancing epithelial-mesenchymal transition process
Conclusions: The report revealed a new mechanism by which LINC01296 regulates the EMT process through miR-141-3p/ZEB1-ZEB2 axis and affects cancer metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zhenqiang Sun, Bo Shao, Zaoqu Liu, Qin Dang, Yaxin Guo, Chen Chen, Yuying Guo, Zhuang Chen, Jinbo Liu, Shengyun Hu, Weitang Yuan, Quanbo Zhou Tags: Research Paper Source Type: research
A snapshot of the PD-1/PD-L1 pathway
Cancer cells can evade the attack from host immune systems via hijacking the regulatory circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by blockade of immune checkpoints is considered as a promising strategy to treat cancer. Programmed death protein 1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) are critical immune checkpoint proteins that responsible for negative regulation of the stability and the integrity of T-cell immune function. Anti-PD-1/PD-L1 drugs have been developed for immune checkpoint blockade and can induce clinical responses across different types of cancer...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Chinmoy Ghosh, Gary Luong, Yue Sun Tags: Review Source Type: research
A Panel of Tumor-associated Autoantibodies for the Detection of Early-stage Breast Cancer
We previously found a panel of autoantibodies against multiple tumor-associated antigens (BMI-1, HSP70, MMP-7, NY-ESO-1, p53 and PRDX6) that might facilitate early detection of esophagogastric junction adenocarcinoma and esophageal squamous cell carcinoma. Here we aimed at assessing the diagnostic performance of these autoantibodies in breast cancer patients. Enzyme-linked immunosorbent assay was applied to detect sera autoantibodies in 123 breast cancer patients and 123 age-matched normal controls. We adopted logistic regression analysis to identify optimized autoantibody biomarkers for diagnosis and receiver-operating ch...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Chao-Qun Hong, Xue-Fen Weng, Xu-Chun Huang, Ling-Yu Chu, Lai-Feng Wei, Yi-Wei Lin, Liu-Yi Chen, Can-Tong Liu, Yi-Wei Xu, Yu-Hui Peng Tags: Research Paper Source Type: research
SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling
In this study, we validate that SAA1 is up-regulated in GBM, and its high expression predicts poor prognosis. SAA1 knockdown promotes the apoptosis of GBM cell. Mechanistically, SAA1 knockdown can inhibit serine/threonine protein kinase B (AKT) phosphorylation, thereby regulating the expression of apoptosis-related proteins such as Bcl2 and Bax, leading to GBM cell death. Moreover, Gliomas with low SAA1 expression have increased sensitivity to Temozolomide (TMZ). Low SAA1 expression segregated glioma patients who were treated with Temozolomide (TMZ) or with high MGMT promoter methylation into survival groups in TCGA and CG...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Huikai Zhang, Yang Xu, Gang Deng, Fanen Yuan, Yinqiu Tan, Lun Gao, Qian Sun, Yangzhi Qi, Kun Yang, Rongxin Geng, Hongxiang Jiang, Baohui Liu, Qianxue Chen Tags: Research Paper Source Type: research
