Changes in Expression of Multiple Checkpoint Molecules and Infiltration of Tumor Immune Cells after Neoadjuvant Chemotherapy in Gastric Cancer
In this study, we aimed to characterize the changes in tumor-infiltrating immune cells and checkpoint molecules following NACT and investigate the prognostic value of these changes in LAGC. Paired tumor samples (pre-NACT and post-NACT) of 60 patients were retrospectively identified and analyzed by multiplex immunohistochemistry with a panel including CD4, CD8, FOXP3, PD-1, PD-L1, and TIM3. Following NACT, the overall median expression levels of CD4, CD8, PD1, PD-L1 and TIM3 were significantly increased (P = 0.008 for PD-L1 and P
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yue Yu, Xiaopeng Ma, Yanjuan Zhang, Yun Zhang, Jianming Ying, Wen Zhang, Qiaofeng Zhong, Aiping Zhou, Yixin Zeng Tags: Research Paper Source Type: research

LNC CRYBG3 inhibits tumor growth by inducing M phase arrest
Long noncoding RNAs (lncRNAs) are usually associated with tumor development and progression and some of them are dysregulated in various human cancers. The mechanisms underlying their dysregulation are worth further study. Here, we demonstrate that the expression level of LNC CRYBG3 is correlated with 1501 aberrantly expressed proteins in A549 cells (non-small cell lung cancer (NSCLC) cells). LNC CRYBG3 overexpression results in M phase arrest and promoted cell death, whereas LNC CRYBG3 knockdown did not elicit the opposite effects. The overexpression of LNC CRYBG3 inhibits cell proliferation both in vitro and in vivo. Mor...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Weidong Mao, Ziyang Guo, Yingchu Dai, Jing Nie, Bingyan Li, Hailong Pei, Guangming Zhou Tags: Research Paper Source Type: research

Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications
Kynurenine (Kyn) pathway is a significant metabolic pathway of tryptophan (Trp). The metabolites of the Kyn pathway are closely correlated with numerous diseases. Two main enzymes, indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO or TDO2), regulate the first and rate-limiting step of the Kyn pathway. These enzymes are directly or indirectly involved in various diseases, including inflammatory diseases, cancer, diabetes, and mental disorders. Presently, an increasing number of potential mechanisms have been revealed. In the present review, we depict the structure of IDO and TDO and explicate their funct...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zixiang Ye, Linxiu Yue, Jiachen Shi, Mingmei Shao, Tao Wu Tags: Review Source Type: research

The characteristics of HPV integration in cervical intraepithelial cells
In conclusion, this study unveiled the HPV integration patterns and the associated recurrent genes in cervical epithelial exfoliated cells. Altogether, our data suggested that the HPV integrations in cervical exfoliated cells might have vital clinical significance, and probably also diagnostic and/or prognostic values in future clinical applications. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Weiping Li, Shuang Tian, Pengpeng Wang, Yikun Zang, Xin Chen, Yuanqing Yao, Weiyang Li Tags: Research Paper Source Type: research

Awareness of surgical smoke hazards and enhancement of surgical smoke prevention among the gynecologists
Surgical smoke is the gaseous by-product produced by heat generating devices in various surgical operations including laser conization and loop electrosurgical procedures that often are performed by gynecologists. Surgical smoke contains chemicals, blood and tissue particles, bacteria, and viruses, which has been shown to exhibit potential risks for surgeons, nurses, anesthesiologists, and technicians in the operation room due to long term exposure of smoke. In this review, we describe the detailed information of the components of surgical smoke. Moreover, we highlight the effects of surgical smoke on carcinogenesis, mutag...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yi Liu, Yizuo Song, Xiaoli Hu, Linzhi Yan, Xueqiong Zhu Tags: Review Source Type: research

High Expression of Plakoglobin Promotes Metastasis in Invasive Micropapillary Carcinoma of the Breast via Tumor Cluster Formation
We reported here that plakoglobin, as a key component in cell adhesion, can promote collective metastasis through facilitating IMPC clusters formation. In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. Both in vitro and in vivo data showed overexpression of plakoglobin in both the cell membrane and the cytoplasm of IMPC clusters. When plakoglobin was knocked down in IMPC cell models, the tumor cell clusters were depolymerized. Using mouse models,...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lan Huang, Hongfei Ji, Lei Yin, Xingjian Niu, Yiran Wang, Yang Liu, Qijia Xuan, Liru Li, Han Zhang, Xiaoping Zhou, Jingtong Li, Chengwei Cui, Yue Yang, Weiwei An, Qingyuan Zhang Tags: Research Paper Source Type: research

The Value of Serum Immunoglobulin G Glycome in the Preoperative Discrimination of Peritoneal Metastasis from Advanced Gastric Cancer
Conclusions: Here we firstly present IgG glycome profiles in a large number of preoperative peritoneal metastasis serums. The IgG glycan was highly associated with peritoneal metastasis. These findings enhance the understanding of peritoneal metastasis. Besides, our results suggested that the newly established glyco-model could be a reliable predictor of the presence of peritoneal metastasis in patients with advanced gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ruihuan Qin, Yupeng Yang, Wenjun Qin, Jing Han, Hao Chen, Junjie Zhao, Ran Zhao, Can Li, Yong Gu, Yiqing Pan, Xuefei Wang, Shifang Ren, Yihong Sun, Jianxin Gu Tags: Research Paper Source Type: research

Extracellular Ubiquitin is the Causal Link between Stored Blood Transfusion Therapy and Tumor Progression in a Melanoma Mouse Model
Conclusions: The present findings provide novel insights into the role of ubiquitin in immune regulation in a melanoma mouse model, and suggest ubiquitin as the causal link between allogeneic blood transfusion therapy and poor cancer prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jingjun Zhang, Shuying Chen, Yuzhong Yan, Xinfang Zhu, Qi Qi, Yang Zhang, Qi Zhang, Rong Xia Tags: Research Paper Source Type: research

MiR-27a: A Novel Biomarker and Potential Therapeutic Target in Tumors
MicroRNAs (miRNAs) are endogenous, time sequencing, conserved and small non-coding RNA molecules (19-25 bp long) that regulate gene expression at the post-transcriptional level by binding to the partial sequence homology of the 3'-untranslated region of target messenger (m)RNA. The miRNA-27 family consists of miR-27a and miR-27b, which are transcribed from different chromosomes and different in nucleotide at the 3' end. It has been reported that miR-27a was located on chromosome 19 and played a vital role in tumor development. Increasing evidences support a vital role for miR-27a in modulating polymorphisms, tumorigenesis,...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xingwang Li, Min Xu, Li Ding, Jinhai Tang Tags: Review Source Type: research

Ophiopogonin-B Suppresses Epithelial-mesenchymal Transition in Human Lung Adenocarcinoma Cells via the Linc00668/miR-432-5p/EMT Axis
Ophiopogonin-B (OP-B) has been reported to suppress metastasis and angiogenesis of adenocarcinoma A549 cells in vitro and in vivo. More and more evidences indicate that inflammatory microenvironment facilitates tumor metastasis. Digital Gene Expression (DGE) analysis of non-small cell lung cancer (NSCLC) cell lines showed that OP-B downregulated the expression of linc00668, which promoted progression of cancer. Herein, we simulated the inflammatory microenvironment by co-culturing A549 cells with LPS-treated THP-1 cells and found that the level of linc00668 increased significantly in the mock group, while OP-B treatment in...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Cheng Hu, Rilei Jiang, Ziyu Cheng, Yueyang Lu, Ling Gu, Hongxiao Li, Liqiu Li, Qian Gao, Meijuan Chen, Xu Zhang Tags: Research Paper Source Type: research

Resection vs Ablation for Multifocal Hepatocellular Carcinomas meeting the Barcelona-Clinic Liver Cancer A Classification: A Propensity Score Matching Study
With development of surgical technology, we aimed to investigate whether resection could challenge the standard treatment, ablation, in treating multifocal hepatocellular carcinomas meeting the Barcelona-Clinic Liver Cancer A stage. From January 2005 to January 2017, the oncological outcomes of patients undergoing resection (n = 72) or ablation (n = 63) were retrospectively analysed using propensity score matching. At baseline, patients in the ablation group had more tri-focal lesions (30.2% vs. 6.9%, P = 0.001) and smaller tumours (2.00 cm vs. 2.50 cm, P = 0.002) than resection group. After matching, the baseline was well...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wenwu Liu, Zhiwen Yang, Ruhai Zou, Jiliang Qiu, Jingxian Shen, Yadi Liao, Chenwei Wang, Yuanping Zhang, Yongjin Wang, Yichuan Yuan, Kai Li, Dinglan Zuo, Wei He, Yun Zheng, Binkui Li, Yunfei Yuan Tags: Research Paper Source Type: research

Safety and outcomes of volumetric modulated arc therapy in the treatment of patients with inoperable lung cancer
Background: Published data on the effects and toxicities of volumetric modulated arc therapy (VMAT) in the management of inoperable lung cancer are scarce.Materials and methods: The clinical outcomes and pulmonary toxicities of 134 patients with consecutive inoperable lung cancer who underwent VMAT from March 2011 to September 2016 were retrospectively reviewed. The dosimetric and characteristic factors associated with acute radiation pneumonitis (RP) and pulmonary fibrosis were evaluated with univariate and multivariate analysis.Results: The average prescription doses to these 134 patients were 57.07±6.27 Gy (range...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiance Jin, Baochai Lin, Didi Chen, Lili Li, Ce Han, Yongqiang Zhou, Xiaomin Zheng, Changfei Gong, Mengfeng Chen, Congying Xie Tags: Research Paper Source Type: research

CDC25A Facilitates Chemo-resistance in Ovarian Cancer Multicellular Spheroids by Promoting E-cadherin Expression and Arresting Cell Cycles
In this study, gene expression analysis implicated that ovarian cancer MCS had its unique expression pattern and the cell cycle-related pathways were prominently altered in MCS cells compared to the monolayer adherent cells. Flow cytometry and western blots confirmed the cell cycle stagnancy in MCS. Among the cell cycle-related proteins, we found that expression of CDC25A was upregulated in MCS and displayed a time-dependent decrease during the transition from MCS to monolayer adherent cells. Loss-of-function studies showed that CDC25A promoted cisplatin-resistance and paclitaxel-resistance and inhibited the drug-induced a...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yiting Sun, Song Li, Lu Yang, Di Zhang, Zeyi Zhao, Jing Gao, Lian Liu Tags: Research Paper Source Type: research

Regulatory mechanisms and clinical perspectives of circRNA in digestive system neoplasms
A new star, circular RNA (circRNA), is a class of noncoding RNA with a stable cyclic structure. Exonic circRNA mainly exists in the eukaryotic cytoplasm. Intronic circRNAs (ciRNA) and exonic circRNAs with introns (EIciRNA) are found in the nucleus. Recent evidences showed the functional diversity of circRNAs, which could be microRNA (miRNA) sponges, interact with protein or translate into small peptide. Due to the change of human eating habits, digestive cancer remains one of the most common cancers worldwide and it is prone to metastasis. Increasing studies have found a number of circRNAs using RNA sequencing technology a...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhenqiang Sun, Chen Chen, Yingfeng Su, Weiwei Wang, Shuaixi Yang, Quanbo Zhou, Guixian Wang, Zhen Li, Junmin Song, Zhiyong Zhang, Weitang Yuan, Jinbo Liu Tags: Review Source Type: research

Exosomes from Macrophages Exposed to Apoptotic Breast Cancer Cells Promote Breast Cancer Proliferation and Metastasis
Exosomes have recently become the subject of increasing research interest. Interactions between tumor and host cells via exosomes play crucial roles in the initiation, progression and invasiveness of breast cancer. In our study, we used exosomes isolated from a co-culture model of THP-1-derived macrophages exposed to apoptotic MCF-7 or MDA-MB-231 breast cancer cell line cells to investigate their effects on naïve MCF-7 or MDA-MB-231 cells in vitro and in vivo. This post-chemotherapy tumor microenvironment model allowed us to explore possible mechanisms that explain increased proliferation and metastasis of breast canc...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiuyan Yu, Qun Zhang, Xuehui Zhang, Qing Han, Hui Li, Yiqing Mao, Xi Wang, Hongyan Guo, David M. Irwin, Gang Niu, Huanran Tan Tags: Research Paper Source Type: research

Association of EGFR mutations and HMGB1 genetic polymorphisms in lung adenocarcinoma patients
In conclusion, our results suggested that HMGB1 variants are significantly inversely associated with EGFR mutations among NSCLC patients who smoked. HMGB1 variants and tobacco consumption might contribute to the pathological development of NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yi-Liang Wu, Ming-Hsien Chien, Ying-Erh Chou, Jer-Hwa Chang, Tu-Chen Liu, Thomas Chang-Yao Tsao, Ming-Chih Chou, Shun-Fa Yang Tags: Research Paper Source Type: research

Glutathione S-transferases genes variants and chemotherapy efficacy in gastrointestinal cancer patients: a meta-analysis based on 50 pharmacogenetic studies
Conclusion: This meta-analysis illustrates that GSTP1 IIe105Val and GSTT1 null/present variants could be useful predictors of chemotherapy efficacy in patients with gastrointestinal cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yuesheng Sun, Jianghua Pan, Xiaochun Tong, Ende Chen, Wangxin Yan, Mengpei Wu, Qiang Qu, Jian Qu Tags: Research Paper Source Type: research

Development and validation of lncRNAs-based nomogram for prediction of biochemical recurrence in prostate cancer by bioinformatics analysis
Conclusion: In conclusion, our lncRNAs-based nomogram is a reliable prognostic tool for BCR in PCa patients. In addition, the present study put forward the direction for the further investigation on the mechanism of PCa progression. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ning Shao, Hong Tang, Yuanyuan Qu, Fangning Wan, Dingwei Ye Tags: Research Paper Source Type: research

Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population
Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more effective treatment. The development and progression of lung cancer is stimulated by angiopoietin-2 (Ang2), a ligand for Tie2, an endothelial tyrosine kinase. Patients with lung cancer with higher serum Ang2 levels have significantly poorer survival than patients with lower serum Ang2 levels. We explored the ef...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Weiwei Hu, Chih-Hsin Tang, Hsien-Te Chen, Jin Zhao, Lulu Jin, Le Kang, Yueming Wu, Pengqing Ying, Chao-Qun Wang, Chen-Ming Su Tags: Research Paper Source Type: research

Sorting Nexin 5 Controls Head and Neck Squamous Cell Carcinoma Progression by Modulating FBW7
Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer worldwide. Long-term survival rates in patients with HNSCC have not increased significantly in the past 30 years. Therefore, looking for novel molecular targets that control HNSCC progression is urgently required to improve the treatment of HNSCC. Here, we identified Sorting Nexin 5 (SNX5) as a new regulator that plays an oncogenic function in HNSCC progression. Analyzing HNSCC patients' data from the Cancer Genome Atlas (TCGA) indicates that the expression levels of SNX5 in HNSCC are significantly elevated compared to normal tissues. Furtherm...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jinyang Cai, Ming Sun, Bin Hu, Brad Windle, Xin Ge, Guoping Li, Yue Sun Tags: Research Paper Source Type: research

Three Biomarkers Predict Gastric Cancer Patients' Susceptibility To Fluorouracil-based Chemotherapy
Conclusion: Our data established three genes-based predictive model which might predict GC patients' susceptibility to fluorouracil and help clinicians develop personalized treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jiaomeng Pan, Qingqiang Dai, Zhen Xiang, Bingya Liu, Chen Li Tags: Research Paper Source Type: research

Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway
In this study, we confirm linc01023 is up-regulated in glioma tissues and cell lines. In addition, elevated linc01023 expression indicates shorter survival times in patients with glioma. Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. Collectively, the study indicates that linc01023 plays an oncogenic role in glioma through activation of IGF1R/AKT signal pathway, and it could be a candidate therapeutic target. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mingjun Yu, Shijia Yu, Wei Gong, Duo Chen, Junhong Guan, Yunhui Liu Tags: Research Paper Source Type: research

Toll-like receptor 6 expression, sequence variants, and their association with colorectal cancer risk
This is the first study to examine the potential correlation of the rs3796508 and rs5743810 SNPs of the TLR6 gene in patients with colorectal cancer (CRC) in a subset of the Saudi population. TLR6 gene expression was studied by real-time PCR assaysin 10 matching normal and cancer colon tissues. TLR6 expression at the protein level was determined by immunohistochemistry. A case-control search was conductedon 115 case patients and 102 controls. All samples were genotyped with the TaqMan assay for the TLR6 gene. Odds ratios and 95% confidence interval were computed from logistic regression models after adjusting for age, sex,...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Abdelhabib Semlali, Mikhlid Almutairi, Akbar Ali Khan Pathan, Arezki Azzi, Narasimha Reddy Parine, Abdullah AlAmri, Maha Arafah, Abdulrahman M Aljebreen, Othman alharbi, Majid A Almadi, Nahla Ali Azzam, Mohammad Alanazi, Mahmoud Rouabhia Tags: Research Paper Source Type: research

A Retrospective Clinicopathological Study of Osteosarcoma Patients with Metachronous Metastatic Relapse
This study aimed to explore the clinicopathological features and prognostic factors of osteosarcoma patients with metachronous metastatic relapse.Patients and methods: We retrospectively analyzed 59 patients, between January 1st, 2004 and December 31st, 2013. Employed Chi-square test to recognize the differences in clinicopathological characteristics between early and late metastatic patients, and the differences between shorter and longer survival patients. Used the Kaplan-Meier method to evaluate the survival data, cox step proportional hazard test to analyze the prognostic factors associated with OS.Results: We found th...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Junjie Bao, Jingya Zeng, Chunyu Song, Hongwei Yu, Qingyu Shi, Wei Mai, Guofan Qu Tags: Research Paper Source Type: research

Liver Metastases in Newly Diagnosed Gastric Cancer: A Population-Based Study from SEER
Conclusions: The findings of this study provided population-based estimates of the proportion and prognosis for LM at time of GC diagnosis. These findings provide preventive guidelines for screening and treatment of LM in GC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zepang Sun, Huan Zheng, Jiang Yu, Weicai Huang, Tuanjie Li, Hao Chen, Yanfeng Hu, Mingli Zhao, Hao Liu, Yuming Jiang, Guoxin Li Tags: Research Paper Source Type: research

Serum Prealbumin is Negatively Associated with Survival in Hepatocellular Carcinoma Patients after Hepatic Resection
Objective: Low serum prealbumin levels are associated with poor prognoses in some type of cancers. However, the role of prealbumin in patients with hepatocellular carcinoma (HCC) is unknown. The present study aimed to investigate the role of serum prealbumin levels in long-term survival for HCC patients after hepatic resection.Methods: HCC patients who underwent hepatic resection from June 2007 to December 2015 were retrospectively analyzed in a tertiary liver center. Patients were classified as having normal or reduced serum prealbumin based on a cut-off value of 200 mg/L. Overall survival and recurrence rate were analyze...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ying-Yang Liao, Chun-Lan Teng, Ning-Fu Peng, Rong-Rong Jia, Jing Cui, Kang Chen, Liang Ma, Bang-De Xiang, Jian-Hong Zhong, Le-Qun Li Tags: Research Paper Source Type: research

Triptolide sensitizes cisplatin-resistant human epithelial ovarian cancer by inhibiting the phosphorylation of AKT
Advanced and chemotherapy-resistant ovarian cancer causes high mortality of ovarian cancer, and it is important to find safe and effective drugs to reduce the chemotherapeutic resistance of ovarian cancer. In our study, we attempted to clarify the resistance mechanisms of SKOV3/DDP cells in vitro and evaluated the sensitization to triptolide (TPL) in vivo. Our results indicated that the overexpression of AKT and p-AKT greatly enhanced the cisplatin (DDP) tolerance of SKOV3/DDP, and the combination of DDP+TPL had a significant tumour inhibition effect compared to DDP treatment (p
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Genhua Huang, Hui Hu, Yao Zhang, Yinfang Zhu, Junli Liu, Buzhen Tan, Tingtao Chen Tags: Research Paper Source Type: research

Aging, Cancer and Immunity
Cancers are being frequently diagnosed in the elderly. Immunosenescence which refers to the gradual deterioration of the immune system brought on by natural age advancement, has been the key cross center in the increasing frequency and severity of cancer, aging and immunity. Monoclonal antibodies targeting immune checkpoint molecules CTLA-4, PD-1 or PD-L1 are the promising anticancer therapeutics in multiple cancer subtypes generating remarkable and long-lasting clinical responses. These immune checkpoint blockers (ICBs)have already obtained approval for the treatment of patients with metastatic melanoma, advanced/refracto...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hong Hong, Qi Wang, Jing Li, Hans Liu, Xin Meng, Haiyan Zhang Tags: Review Source Type: research

Estradiol and Progesterone Induced Differentiation and Increased Stemness Gene Expression of Human Fallopian Tube Epithelial Cells
In conclusion, hormones may alter the gene expressions of FTECs, and these cells may provide new insights into how FTECs regenerate in response to hormones. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yu-Hsun Chang, Dah-Ching Ding, Tang-Yuan Chu Tags: Research Paper Source Type: research

Incidence of metastatic disease and survival among patients with newly diagnosed primary CNS tumors in the United States from 2004-2013
Background: Population-based estimates of the incidence and prognosis of metastatic disease at the initial diagnosis of primary central nervous system (CNS) tumors are currently lacking.Methods: A total of 43,455 patients diagnosed with a primary CNS tumor were enrolled to evaluate metastatic rates utilizing the data from the Surveillance, Epidemiology, and End Results (SEER) program. We used multivariate logistic regression to analyze the risk factors associated with the presence of metastasis at the first visit of patients with metastatic medulloblastoma (MB), atypical teratoid/rhabdoid tumor (ATRT), glioblastoma multifo...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hao Lian, Craig Daniels, Yi-Peng Han, Qi-Feng Li, Yang Zhao, Bao-Cheng Wang, Chang-Bin Zhu, Wei-Wei Mao, Michael D. Taylor, Jie Ma Tags: Research Paper Source Type: research

Expression of WDR79 is associated with TP53 mutation and poor prognosis in surgically resected non-small cell lung cancer
Non-small cell lung cancer (NSCLC) represents a major health burden globally. WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family. WDR79 is a highly conserved and natural antisense transcript to TP53 gene and involved in carcinogenesis of various types of cancer. Whether the alterations of WDR79 protein expression are associated with TP53 mutation and clinicopathological and prognostic implications in the patients with surgically resected NSCLC have not been reported. The purposes of the present study are to investigate the association between the expression of WDR79 and mutant p53 (mtp53) and clinicop...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jinwu Peng, Yuting Zhan, Juan Feng, Songqing Fan, Hongjing Zang Tags: Research Paper Source Type: research

Carcinoma of the lower female genital tract in patients with genitourinary malformations: a clinicopathologic analysis of 36 cases
Background: Lower genital tract carcinomas that coexist with genitourinary malformations are rare. The aim of this study was to investigate the clinicopathologic characteristics and outcomes of patients with this rare joint condition. The aim of this study was to investigate the clinicopathologic characteristics and outcomes of these patients to analyze the associations among clinicopathologic features in this rare entity.Methods: The medical records of patients with carcinoma of lower genital tract combined with genital tract malformations who were treated at Peking Union Medical College Hospital (Beijing, China) between ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Liju Zong, Wenze Wang, Yonglan He, Ninghai Cheng, Yang Xiang Tags: Research Paper Source Type: research

Risk Factors Analysis of Pathologically Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results from a Cancer Center of Central China
Objective: To explore the risk factors of cervical lymph node metastasis in oral squamous cell carcinoma (OSCC) patients with clinical negative cervical lymph nodes(cN0) and provide a reference for clinical treatment.Methods: The clinical data of 161 OSCC patients with cN0 were retrospectively analyzed. All patients underwent extended primary resection combined with cervical lymph node dissection. The level and number of cervical lymph node metastasis were confirmed by postoperative pathology. The risk factors of cervical lymph node metastasis in patients were analyzed by univariate and multivariate Logistic regression ana...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yonghong Li, Ke Liu, Yuan Ke, Yifei Zeng, Mengge Chen, Wei Li, Wenming Liu, Xinying Hua, Zheng Li, Yahua Zhong, Conghua Xie, Haijun Yu Tags: Research Paper Source Type: research

Clinicopathological and prognostic significance of programmed death ligand 1 expression in Korean melanoma patients
Programmed death ligand 1 (PD-L1) expression provides significant value to predict prognosis and response following immunotherapy in several types of cancers. However, its clinicopathological and prognostic significance in melanoma remains unclear. PD-L1 and the number of tumor infiltrating lymphocytes (TILs) were investigated in 63 Korean patients with melanoma based on the melanoma scoring system. We also compared the results using the PD-L1 antibodies—22C3 and E1L3N clones. In addition, BRAF gene mutation was detected using anti-BRAF antibody and real-time polymerase chain reaction. Overall, 29 (46.0%), 16 (25.4%)...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sumi Yun, Yujun Park, Seyoung Moon, Soomin Ahn, Kyoungyul Lee, Hyo Jin Park, Hye Seung Lee, Gheeyoung Choe, Kyu Sang Lee Tags: Research Paper Source Type: research

Prognostic value of site-specific metastases in lung cancer: A population based study
Background: Studies on prognosis of different metastasis sites in patients with lung cancer are limited. The aim of present study was to investigate the prognostic value of metastases sites among patients with metastatic lung cancer.Methods: Between 2010 and 2014, patients diagnosed with metastatic lung cancer were selected using the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier methods were adopted and multivariable Cox regression models were built to compare the prognosis of different metastasis sites.Results: A total of 54,697 eligible patients were identified, including 10,945 (20.0%) patien...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jing Li, Huaguang Zhu, Lei Sun, Wenqian Xu, Xin Wang Tags: Research Paper Source Type: research

Prophylactic Endoscopic Therapy for Variceal Bleeding in Patients with Hepatocellular Carcinoma
Conclusions: Ligation combined with cyanoacrylate could be preferred for HCC patients presented with both esophageal and gastric varices. BCLC C/D stage predicted shorter survival times and bleeding relapse, while male gender was an independent predictor of poor survival. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jie Chen, Yujen Tseng, Tiancheng Luo, Na Li, Lili Ma, Shiyao Chen Tags: Research Paper Source Type: research

The optimal strategy of multimodality therapies for resectable gastric cancer: evidence from a network meta-analysis
Conclusions: Our study showed no significant survival advantage for neoadjuvant CRT, though the highest probability of being the best treatment was observed. Further clinical trials are essential to determine the value of neoadjuvant CRT, especially in D2 lymphadenectomy subgroup. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Songcheng Yin, Pengliang Wang, Xiaoyu Xu, Yuen Tan, Jinyu Huang, Huimian Xu Tags: Research Paper Source Type: research

The Immune Checkpoint Regulator PDL1 is an Independent Prognostic Biomarker for Biochemical Recurrence in Prostate Cancer Patients Following Adjuvant Hormonal Therapy
Background: The programmed death 1 (PD1)/programmed death ligand 1 (PDL1) targeted therapies have gained positive outcomes in several tumors, but the evidence of the expression and prognosis value of PD1/PDL1 in high risk prostate cancer was rare.Methods: Immunohistochemical analysis of PDL1/PD1 expression by a validated antibody was performed in a retrospectively collected high risk prostate cancer cohort who received adjuvant hormonal therapy (AHT) after radical prostatectomy (RP). The association between PDL1/PD1 expression and prognosis was determined.Results: In total, 127 patients were enrolled. 49.6% patients were c...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Heng Li, Zhize Wang, Yucong Zhang, Guoliang Sun, Beichen Ding, Libin Yan, Haoran Liu, Wei Guan, Zhiquan Hu, Shaogang Wang, Fei Cheng, Hua Xu, Xu Zhang, Zhangqun Ye Tags: Research Paper Source Type: research

A long way to the battlefront: CAR T cell therapy against solid cancers
Chimeric antigen receptors (CARs) are engineered synthetic receptors that redirect and reprogram T cells to tumor surface antigens for subsequent eradication. The unprecedented efficacy of CD19-CAR T cells against B-cell malignancies has inspired oncologists to extend these efforts for the treatment of solid tumors. However, limited success has been achieved so far, partially due to some of the formidable challenges, e.g. suppression of full activation, inhibition of T cell localization, lacking of ideal targets, inefficient trafficking and infiltration, immunosuppression of microenvironment, and the probability of off tar...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhicai Wang, Wei Chen, Xing Zhang, Zhiming Cai, Weiren Huang Tags: Review Source Type: research

Young-onset breast cancer: a poor prognosis only exists in low-risk patients
The number of reported young breast cancer cases has increased dramatically recently. The impact of age on the outcomes of breast cancers remains controversial. Our study aimed to explore the factors that can stratify the impact of young age on the prognosis of early breast cancer patients. In total, 244,324 patients with early breast cancer in the Surveillance, Epidemiology, and End Results database were identified from 1990 to 2007. Survival curves were generated using the Kaplan-Meier method. The 5- and 10-year cancer-specific survival (CSS) rates were calculated using the Life-Table method. Multivariable analyses were ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jianfei Fu, Lunpo Wu, Tiantian Xu, Dan Li, Mingliang Ying, Mengjie Jiang, Ting Jiang, Wei Fu, Fan Wang, Jinlin Du Tags: Research Paper Source Type: research

The prevalence, associated factors for bone metastases development and prognosis in newly diagnosed ovarian cancer: a large population based real-world study
Background: Ovarian cancer (OC) is one of the most common malignancies in women. Advanced bone metastases (BM) commonly result in the poor prognosis. We aim to evaluate the prevalence and associated factors for the de novo BM development and prognosis in OC.Materials and methods: The present study was a cohort study that used the United States based National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database. SEER documented OC patients, diagnosed between 2010 and 2015, were included in the present study. Univariable and multivariable logistic regression analyses were employed to identify associ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chao Zhang, Xu Guo, Karl Peltzer, Wenjuan Ma, Lisha Qi, Yanting Zhang, Xiuxin Han, Vladimir P. Baklaushev, Yueliang Yao, Guowen Wang, Vladimir P. Chekhonin, Xin Wang, Yulin Ma Tags: Research Paper Source Type: research

The impact of primary tumor site on outcomes of treatment with etoposide and cisplatin in grade 3 gastroenteropancreatic neuroendocrine carcinoma
Conclusion: Results from this study showed that RR and PFS associated with EP treatment were not different based on the primary tumor site in patients with advanced or metastatic GEP-NEC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sang Eun Yoon, Jung Hoon Kim, Su Jin Lee, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park, Seung Tae Kim Tags: Research Paper Source Type: research

Comparison on Clinicopathological Features, Treatments and Prognosis between Proximal Gastric Cancer and Distal Gastric Cancer: A National Cancer Data Base Analysis
Conclusion: PGC and DGC differed in their clinicopathologic characteristics and prognosis and heterogeneity may be due to differences in tumor biology. Tumor location should be taken into consideration when stratifying patients for optimal therapeutic strategies. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiang Wang, Fangfang Liu, Yumin Li, Song Tang, Yawei Zhang, Yingtai Chen, Sajid A. Khan Tags: Research Paper Source Type: research

Identification of microRNA-92a and the related combination biomarkers as promising substrates in predicting risk, recurrence and poor survival of colorectal cancer
Conclusions: Current evidences suggest miR-92a is a promising biomarker for early detection and prognosis of CRC while miRNA combination biomarkers may be considered as the right way for clinical practice. However, more prospective studies are required to highlight the theoretical strengths. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qiliang Peng, Yi Shen, Kaisu Lin, Li Zou, Yuntian Shen, Yaqun Zhu Tags: Research Paper Source Type: research

High delta-like ligand 4 expression correlates with a poor clinical outcome in gastric cancer
Conclusion: High DLL4 expression was observed in 19.9% of GC patients and was significantly associated with poor survival following curative surgery. Given its prevalence in the GC cohort with a poor prognosis, DLL4 is a potential therapeutic target. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Youjin Kim, Sun-ju Byeon, Joonyoung Hur, Kangkook Lee, Dongin Kim, Jin-Hyung Ahn, Sang Hoon Lee, Weon-Kyoo You, Seung Tae Kim, Se Hoon Park, Won Ki Kang, Kyoung-Mee Kim, Jeeyun Lee Tags: Research Paper Source Type: research

Intensive Care Unit Admission and Survival in Stage IV Cancer Patients with Septic Shock: A Population-Based Cohort Study
Conclusions: Though ICU admission with aggressive treatment may be associated with improved survival, the majority (70%) of stage IV cancer patients with septic shock were unable to survive until hospital discharge. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Meng-Rui Lee, Chao-Lun Lai, K. Arnold Chan Tags: Research Paper Source Type: research

Systemic immune-inflammation index (SII) is useful to predict survival outcomes in patients with surgically resected esophageal squamous cell carcinoma
This study was a single-institution, retrospective analysis of 468 ESCC patients who underwent curative esophagectomy at the Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between 2005 and 2008. The receiver operating curve (ROC) was plotted to compare the discrimination ability of the SII and other inflammatory factors for overall survival (OS) and disease-free survival (DFS). Univariate and multivariate analyses were performed based on the Cox proportional hazards regression model.Results: The SII, neutrophil-lymphocyte ratio (N...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yibo Gao, Wei Guo, Songhua Cai, Fan Zhang, Fei Shao, Guochao Zhang, Tiejun Liu, Fengwei Tan, Ning Li, Qi Xue, Shugeng Gao, Jie He Tags: Research Paper Source Type: research

Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin
In this study, we found NTN1 expression was significantly increased in 97 tumor tissues from GC patients and positively correlated with NI (p
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Kai Yin, Linjun Wang, Yiwen Xia, Shengchun Dang, Xuan Zhang, Zhongyuan He, Jianghao Xu, Mengyuan Shang, Zekuan Xu Tags: Research Paper Source Type: research

Comparison between CT and MRI in the Diagnostic Accuracy of Thymic Masses
Conclusion: The diagnostic accuracy of MRI is superior to CT in detecting thymomas, thymic cysts or thymic hyperplasia but that of CT and MRI is still unclear in differentiating thymic carcinomas and lymphomas/germ cell tumors. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hao-Ran Li, Jian Gao, Chun Jin, Jia-Hao Jiang, Jian-Yong Ding Tags: Research Paper Source Type: research

Efficacy and safety of nimotuzumab in addition to radiotherapy and temozolomide for cerebral glioblastoma: a phase II multicenter clinical trial
Conclusions: Our study show that nimotuzumab in addition to standard treatment is well tolerable and has increased survival in newly diagnosed GBM patients with EGFR positive expression. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiao-Jing Du, Xian-Ming Li, Lin-Bo Cai, Jian-Cong Sun, Si-Yang Wang, Xi-Cheng Wang, Xiao-Lin Pang, Mei-Ling Deng, Fang-Fang Chen, Zhi-Qiang Wang, Fu-Rong Chen, Hong-Hong Zhang, Hui-Yun Wang, Patricia Piedra, Zhong-Ping Chen, Jun Lin, Shao-Xiong Wu Tags: Research Paper Source Type: research