MiR-200a Regulates Nasopharyngeal Carcinoma Cell Migration and Invasion by Targeting MYH10
Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. However, no relevant studies have been found in NPC. In present study, we found in 48 NPC specimens, MYH10 level was lower in most cancer areas than that in the adjacent normal tissue. Moreover, the depletion of MYH10 can promote the migration and invasion of NPC. In addition, we demonstrated that miR-200a has the s...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wenya Liu, Tonghui Cai, Lingjun Li, Hui Chen, Ruichao Chen, Minfen Zhang, Wei Zhang, Li Zhao, Hanzhen Xiong, Ping Qin, Xingcheng Gao, Qingping Jiang Tags: Research Paper Source Type: research

TNFAIP8 promotes the migration of clear cell renal cell carcinoma by regulating the EMT
Conclusion: High expression of TNFAIP8 reinforces migration and regulates the EMT in ccRCC, conferring the metastatic potential of ccRCC and suggesting that TNFAIP8 may be a potential therapeutic target for the treatment of advanced ccRCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Mengya Zhong, Maoshu Zhu, Yu Liu, Ying Lin, Lianghai Wang, Yuhan Ye, Huiyu Chen, Yan Yang, Guohong Zhuang, Jiyi Huang Tags: Research Paper Source Type: research

MiR-34a-5p Inhibits Proliferation, Migration, Invasion and Epithelial-mesenchymal Transition in Esophageal Squamous Cell Carcinoma by Targeting LEF1 and Inactivation of the Hippo-YAP1/TAZ Signaling Pathway
Conclusion: Our results indicate miR-34a-5p inhibits proliferation, migration, invasion and EMT in ESCC by targeting LEF1 and suppressing the Hippo-YAP1/TAZ signaling pathway, which may provide a new antitumor strategy to delay ESCC progress. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xinyu Wang, Yue Zhao, Qijue Lu, Xiang Fei, Chaojing Lu, Chunguang Li, Hezhong Chen Tags: Research Paper Source Type: research

Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation
Conclusions: Donor Rap1A rs494453 is a potential predictive marker for HCC recurrence risk after LT. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Rulin Zhang, Junyi Wu, Yiming Yang, Dongge Xia, Jiayong Li, Heng Quan, Ziguang Niu, Ye Yang, Jun Wu Tags: Research Paper Source Type: research

Riluzole Enhances the Response of Human Nasopharyngeal Carcinoma Cells to Ionizing Radiation via ATM/P53 Signalling Pathway
In this study, we determined the effect of riluzole on apoptosis, cell cycle, migration, and invasion in NPC cell lines and investigated its mechanism at the molecular level. By using the human NPC cell lines CNE1, CNE2, and HNE1, we revealed that riluzole effectively inhibited viability of the NPC cell lines in dose- and time-dependent manners. Furthermore, riluzole dose-dependently induced apoptosis and G2/M cell cycle arrest in the NPC cell lines. After combination with radiotherapy (RT), greater cytotoxicity was achieved than with riluzole or RT alone in vitro and vivo. This was associated with the activation of ataxia...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lu Sun, Cheng Wu, Jun Ming, Xin Nie, Ergang Guo, Wei Zhang, Guoqing Hu Tags: Research Paper Source Type: research

Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells
The microenvironment of solid tumors plays an essential role in tumor progression. In lung cancer, the stromal cells produce a fibronectin rich extracellular matrix which is known to contribute to both tumor metastasis and drug resistance. Due to its conformational lability, fibronectin is considerably remodeled by the contractile forces of the fibrotic microenvironment within the tumor stroma. As a result, the secondary structure of fibronectin's Type III domains is disrupted and the molecule becomes highly stretched. The contribution/impact of these strained forms of fibronectin on tumor growth and metastasis is not know...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Christina Cho, Carol Horzempa, Christine M. Longo, Donna M. Peters, David M. Jones, Paula J. McKeown-Longo Tags: Short Research Paper Source Type: research

The Status of the EGFR T790M Mutation is associated with the Clinical Benefits of Osimertinib Treatment in Non-small Cell Lung Cancer Patients: A Meta-Analysis
Background and Purpose: Pervious studies have demonstrated that the loss of EGFR T790M after Osimertinib treatment may be the cause of Osimertinib resistance. Here, we conducted a meta-analysis to evaluate the association between the persistence of EGFR T790M and the clinical benefits of Osimertinib in non-small cell lung cancer (NSCLC) patients with baseline EGFR T790M mutation.Experimental design and Methods: PUBMED, EMBASE, and Cochrane databases were searched for eligible studies that provided the survival outcomes including overall survival (OS), progression-free survival (PFS) or time to discontinuation (TTD) data fo...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhe Zhao, Lu Li, Zhijie Wang, Jianchun Duan, Hua Bai, Jie Wang Tags: Research Paper Source Type: research

Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer
In conclusion, Bufalin can be used as a new promising anticancer drug for gallbladder cancer patients who are resistant to traditional chemotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Liqiang Qian, Haoyuan Su, Gang Wang, Bin Li, Genhai Shen, Quangen Gao Tags: Research Paper Source Type: research

Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis
Conclusions: Late diagnosis indicated poor prognosis in COAD and dy-regulated PRDXs w might be new markers for its early diagnosis. Age was prognostic and should be considered in the treatments of the older patients. Dy-regulated PRDXs were negatively correlated with immune infiltration levels. CD4+ T cell and CD8+ T cell infiltrations were prognostic in COAD and their potential as immune targets needed further investigation. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiuzhi Zhang, Fenglan Gao, Ningning Li, Jinzhong Zhang, Liping Dai, Hongmei Yang Tags: Research Paper Source Type: research

Gastrointestinal toxic effects in patients with cancer receiving platinum-based therapy
Conclusions: PCD is rare, but in a small subset of patients, it can lead to serious complications. Treatment of PCD is mainly supportive, but immunosuppressive therapy may be required. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hamzah Abu-Sbeih, Niharika Mallepally, Ryan Goldstein, Ellie Chen, Tenglong Tang, Uzoamaka K. Dike, Mazen Al-Asadi, Shannon Westin, Daniel Halperin, Yinghong Wang Tags: Research Paper Source Type: research

Overexpression of DUSP6 enhances chemotherapy-resistance of ovarian epithelial cancer by regulating the ERK signaling pathway
Objective: DUSP6 is a negative regulator of the ERK signaling pathway and plays an important role in chemotherapy-resistance. Previously we showed that DUSP6 is overexpressed in ovarian cancer side population (SP) cells that possess cancer stem cell-like properties and are quiescent and chemotherapy-resistant. Here, we explore the effects of DUSP6 on chemotherapy-resistance by examining its regulation of the ERK signaling pathway and G0/G1 cell cycle arrest.Methods: mRNA and protein expression of DUSP6 and G0/G1 cell cycle checkpoint regulating proteins (CyclinD1, CyclinD3 and CyclinE2) was evaluated among ovarian cancer c...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yan Gao, Hui Li, Qing Han, Yuan Li, Tongxia Wang, Cuiyu Huang, Yiqing Mao, Xi Wang, Qun Zhang, Junrui Tian, David M. Irwin, Huanran Tan, Hongyan Guo Tags: Research Paper Source Type: research

Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer
Conclusions: LMR alone and combined with CA125 might be used as predictive markers in OC. Furthermore, as a prognostic factor, COLC might have a higher specificity to predict the outcome. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ying Tang, Hui-quan Hu, Fang-xiang Tang, Dan Lin, Rui Shen, Li Deng, Ya-lan Tang, Li-hong Deng, Mi Zhou, Jun Li, Bin Su, Fan Xu Tags: Research Paper Source Type: research

TBX2 Expression predicts Tumor Recurrence and Adjuvant Chemotherapy Benefits in Gastric Cancer Patients following R0 Resection: a proposed approach for risk stratification
Conclusion: TBX2 may be not only a useful prognostic marker for GC but also a predictive biomarker of response to PAC in stage II/III GC patients. The current findings warrant further verification. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jun Lu, Yu Xu, Yao-hui Wang, Xiao-yan Huang, Yuan Wu, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Ping Li, Chao-hui Zheng, Ai-min Huang, Chang-ming Huang Tags: Research Paper Source Type: research

The long-term outcomes in adolescent and young adult patients with colorectal cancer -A multicenter large-scale cohort study
Introduction: The prognosis of adolescent and young adult (AYA) patients with colorectal cancer (CRC) is still unclear. The aim of this study was to investigate the clinical features and prognosis in AYA patients compared with middle- aged patients.Methods: Participants were identified from a clinical database of the multicenter cohort in Japan. The AYA group was defined as those
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yujiro Nakayama, Hiroshi Kobayashi, Hidetaka Kawamura, Rie Matsunaga, Yukitoshi Todate, Yoshinao Takano, Keiichi Takahashi, Shinichi Yamauchi, Kenichi Sugihara, Michitaka Honda Tags: Research Paper Source Type: research

Association of benign gynaecological diseases and risk of endometrial and ovarian cancers
Conclusion: Our observational data suggested that uterine fibroids or endometriosis may be not associated with the increased risk of developing endometrial or ovarian cancer. However, a history of adenomyosis may do. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fanghua Shen, Yang Liu, Luling Lin, Min Zhao, Qi Chen Tags: Research Paper Source Type: research

Patients with non-colorectal cancers may be at elevated risk of colorectal neoplasia
Background: Screening for colonic neoplasia has decreased the incidence of colorectal cancer in the United States in the past two decades. Whether personal history of noncolorectal cancer is a risk factor for colonic neoplasia has not been well studied. We assessed the risk of colorectal neoplasia in noncolorectal cancer survivors.Methods: We conducted a retrospective study of patients who had undergone colonoscopy for any indication between 2009 and 2018. Colonic adenoma detection rate and multivariate logistic regression were conducted to assess for the primary outcomes of the study.Results: The study included 9408 cance...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hamzah Abu-Sbeih, Faisal S. Ali, Wei Qiao, Phillip Lum, Mehnaz A. Shafi, Robert S. Bresalier, Ernest Hawk, Gottumukkala S. Raju, Yinghong Wang Tags: Research Paper Source Type: research

miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer
In this study, we firstly found that the expression of miR-204-5p markedly decreased in GC patients' tissue and serum, especially in GC with lymphatic metastasis. And ROC analysis showed miR-204-5p also served as a predicted factor for the lymphatic metastasis of GC. CXCL12 and CXCR4 were predicted and confirmed as the functional targets of miR-204-5p by Targetscan analysis, dual luciferase assay and western blotting analysis. In addition, we further determined that miR-204-5p suppresses migration and invasion in GC. This finding elucidates new functions and mechanisms for miR-204-5p in GC development and provides a new po...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Juan Zhang, Ling Xing, Hongwei Xu, Kaixuan Wang, Junjun She, Feiyu Shi, Hongyu Wu, Yongjie Sun, Jun Gao, Shuixiang He Tags: Research Paper Source Type: research

The immune infiltration in clear cell Renal Cell Carcinoma and their clinical implications: A study based on TCGA and GEO databases
In this study, we investigated the differently infiltrated immune cells and their clinical significance in ccRCC for the purpose of shedding some important light on the complex immune microenvironment in ccRCC. The devolution algorithm (CIBERSORT) was applied to infer the proportion of 22 immune infiltrating cells based on gene expression profiles of ccRCC bulk tissue, which were downloaded from TCGA and GEO databases. As a result, we observed considerable differences in immune cells percentage between ccRCC tumor tissue and paired normal tissue; meanwhile, we uncovered their internal correlations and associations with Fuh...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Qiufeng Pan, Longwang Wang, Shuaishuai Chai, Hao Zhang, Bing Li Tags: Research Paper Source Type: research

MicroRNA-129-2-3p directly targets Wip1 to suppress the proliferation and invasion of intrahepatic cholangiocarcinoma
Accumulated studies showed that numerous microRNAs (miRNAs) were aberrantly expressed in human intrahepatic cholangiocarcinoma (ICC) and contributed to the tumorigenic processes. However, whether miR-129-2-3p is implicated in the ICC initiation and progression is still limited. Here, the results revealed that miR-129-2-3p expression was notably decreased in ICC tissues and cell lines, and that a low miR-129-2-3p expression was obviously associated with distant metastasis and clinical stage. Exogenous miR-129-2-3p expression evidently repressed the proliferative and invasive abilities of ICC cells. Mechanistic studies indic...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Chen Chen, Jinqiong Jiang, Meng Fang, Lei Zhou, Yongzhi Chen, Jia Zhou, Yinghui Song, Gaoying Kong, Bao Zhang, Bo Jiang, Hao Li, Chuang Peng, Sulai Liu Tags: Research Paper Source Type: research

Relationship between Aurora-A V57I Polymorphism and the Risk of Cancer: A Meta-Analysis and Trial Sequential Analysis
Conclusion: Our meta-analysis revealed that the susceptibility of cancer was associated with Aurora-A rs1047972 polymorphism, especially in Caucasians. And the GA/GG variant might be a risk factor for cancer susceptibility. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Guangyuan Chen, Cong Hu, Yuxuan Song, Mengxi Xiu, Yiling Zhang, Penghui Lai, Yunyan Li, Xiaoqiang Liu, Peng Huang Tags: Review Source Type: research

Clinical Significance of the Radiological Relationship between the Tumor and the main blood vessels in Enneking IIB Osteosarcoma of the extremities
Aim: Osteosarcoma is one of the most prevalent primary bone malignancies in children and adolescents. Magnetic resonance imaging (MRI) has been considered a very critical tool to provide anatomical information of tumor and surrounding main blood vessels. To evaluate the prognostic significance of the radiological vascular involvement according to the pre-treatment MRI in patients with Enneking IIB osteosarcoma.Methods: In this retrospective study, we included 482 patients younger than 50 years old with Enneking IIB primary osteosarcoma of the extremities with complete clinical records from 2005 to 2015.Univariate and multi...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Qinglin Jin, Xianbiao Xie, Hao Yao, Lili Wen, Hongbo Li, Dongming Lv, Ziliang Zeng, Yongqian Wang, Changye Zou, Junqiang Yin, Gang Huang, Bo Wang, Jingnan Shen Tags: Research Paper Source Type: research

The JAM-B/c-src/MMP9 pathway is associated with progression and regulates the invasion of pancreatic cancer
In conclusion, our results suggest that JAM-B secreted by cancer cells can promote progression and invasion in PanCa by upregulating the c-Src signal and related downstream proteins. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wunai Zhang, Rui He, Shuo Chen, Li Zhang, Gang Cao, Wenbin Yang, Junhui Li Tags: Research Paper Source Type: research

High level of H3K4 tri-methylation modification predicts poor prognosis in esophageal cancer
Conclusions: Thus, high levels of H3K4me3 may be used as a meaningful biomarker for HEC prognosis evaluation. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xu-Dong Ye, Bai-Quan Qiu, Dian Xiong, Xu Pei, Na Jie, Hua Xu, Shu-Qiang Zhu, Xiang Long, Zheng Xu, Hai-Bo Wu, Jian-Jun Xu, You-Sheng Huang, Yong-Bing Wu Tags: Research Paper Source Type: research

Early Diagnosis of Prostate Cancer from the Perspective of Chinese Physicians
Prostate cancer (PCa) is the seventh most diagnosed cancer and the tenth leading cause of cancer mortality in China. Unlike the USA, both incidence and mortality continue to increase. In China, PCa is often diagnosed at a locally advanced or metastatic stage, resulting in a high mortality-to-incidence ratio. Implementing regular screening using a well-validated biomarker may result in the earlier diagnosis of localized disease. Furthermore, it is important to be able to distinguish between low-grade and high-grade disease, to avoid subjecting patients to unnecessary biopsies, undertreatment of significant disease, or overt...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wei Yu, Liqun Zhou Tags: Review Source Type: research

The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells
Neuroblastoma (NB) is the most common extra-cranial solid tumor in childhood with the overall 5 years' survival less than 40%. Polo-like kinase 1 (PLK1) is a serine/threonine-protein kinase expressed during mitosis and over expressed in multiple cancers, including neuroblastoma. We found that higher PLK1 expression related to poor outcome of NB patients. BI2536, a small molecule inhibitor against PLK1, significantly reduced cell viability in a panel of NB cell lines, with IC50 less than 100 nM. PLK1 inhibition by BI 2536 treatment induced cell cycle arrest at G2/M phase and cell apoptosis in NB cells. Realtime PCR array re...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhiheng Li, Chun Yang, Xiaolu Li, Xiaojuan Du, Yanfang Tao, Junli Ren, Fang Fang, Yi Xie, Mei Li, Guanghui Qian, Lixiao Xu, Xu Cao, Yi Wu, Haitao Lv, Shaoyan Hu, Jun Lu, Jian Pan Tags: Research Paper Source Type: research

Strategic Trastuzumab Mediated Crosslinking Driving Concomitant HER2 and HER3 Endocytosis and Degradation in Breast Cancer
Efficacious anticancer therapies for targeting plasma membrane receptors with antibody based therapeutics are often contingent on sufficient endocytic delivery of receptor and conjugate to lysosomes. This results in downregulation of receptor activity and, in the case of antibody-drug conjugates (ADCs), intracellular release of a drug payload. The oncogenic receptor HER2 is a priority therapeutic target in breast cancer. Known as an “endocytosis resistant” receptor, HER2 thwarts the receptor downregulating efficiency of the frontline treatment trastuzumab and reduces the potential of trastuzumab-based therapies...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jennifer Mary Wymant, Edward John Sayers, Duncan Muir, Arwyn Tomos Jones Tags: Research Paper Source Type: research

A Preoperative Risk Prediction Model for Lymph Node Examination of Stage I-III Colon Cancer Patients: A Population-Based Study
Conclusions: The model could accurately predict the risk of inadequate lymph node examination before surgery and might provide useful reference for surgeons and pathologists. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yuliuming Wang, Xu Guan, Yukun Zhang, Zhixun Zhao, Zhifeng Gao, Haipeng Chen, Weiyuan Zhang, Zheng Liu, Zheng Jiang, Yinggang Chen, Guiyu Wang, Xishan Wang Tags: Research Paper Source Type: research

Severe loss of visceral fat and skeletal muscle after chemotherapy predicts poor prognosis in metastatic gastric cancer patients without gastrectomy
Conclusion: Low baseline VFA and SMA, as well as the severe loss of VFA and SMA predict poor prognosis for MGC patients treated by EOF regimen. In patients with severe loss of VFA and/or SMA after 2-cycle chemotherapy, the decision of subsequent chemotherapy should be made after deliberate consideration. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wanjing Feng, Mingzhu Huang, Xiaoying Zhao, Siyuan Chen, Chenchen Wang, Jinjia Chang, Weijian Guo, Zhiyu Chen, Hui Zhu, Xiaodong Zhu Tags: Research Paper Source Type: research

Circular RNA MAN2B2 promotes cell proliferation of hepatocellular carcinoma cells via the miRNA-217/MAPK1 axis
In this study, we investigated differences in the expression of circRNA MAN2B2 (circMAN2B2) in hepatocellular tissues and paired normal tissues. We found that knockdown of circMAN2B2 expression in the HCC cell lines Hep-G2 and Huh-7 significantly inhibited cell proliferation by sponging (miRNA) miR-217 and inhibiting its function. Through a series of experiments, we also demonstrated that miR-217 functioned as a tumor suppressor molecule in HCC cells and regulated the expression of mitogen-activated protein kinase 1 (MAPK1). Restoration of MAPK1 rescued repression of cell proliferation induced by circMAN2B2 knockdown. In s...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaoying Fu, Juanjuan Zhang, Xing He, Xu Yan, Jian Wei, Min Huang, Yaya Liu, Jianwei Lin, Hongxing Hu, Lei liu Tags: Research Paper Source Type: research

Early Adverse Events predict Survival Outcomes in HER2-positive Advanced Breast Cancer Patients treated with Lapatinib plus Capecitabine
This study aimed to investigate the impact of early adverse events (AE) following the initiation of lapatinib plus capecitabine on the progression-free survival (PFS) and overall survival (OS) outcomes of human epidermal growth factor receptor 2 (HER2) positive advanced breast cancer (ABC) patients.Methods: A secondary analysis of participants treated with lapatinib plus capecitabine, or ado-trastuzumab emtansine in the clinical trial EMILIA was conducted. Cox proportional hazard analysis was used to assess the impact of AE occurring within the first 42 days of lapatinib plus capecitabine therapy on the PFS and OS outcomes...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fang L.I. Ang, Andrew Rowland, Natansh D. Modi, Ross A. McKinnon, Michael J. Sorich, Ashley M. Hopkins Tags: Research Paper Source Type: research

Prevalence and Genotyping of Cryptosporidium parvum in Gastrointestinal Cancer Patients
Gastrointestinal cancers are the most commonly occurring malignancies which contributing to over 1/5 of cancer incidences worldwide. Increasing evidences have shown that Cryptosporidium spp., an apicomplexan protozoan, is highly associated with gastrointestinal cancers. However, the prevalence of Cryptosporidium spp. infections among gastrointestinal cancer patients in China has not been estimated yet. We here performed a case-control study to evaluate the occurrences of Cryptosporidium spp. in patients with digestive malignancies before chemotherapy and in control population. Nested PCR amplifying 18S rRNA gene was used t...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Nan Zhang, Xiuyan Yu, Hongbo Zhang, Lianying Cui, Xiaoou Li, Xiaowei Zhang, Pengtao Gong, Jianhua Li, Ziyi Li, Xiaocen Wang, Xin Li, Ting Li, Xiaofeng Liu, Yanhui Yu, Xichen Zhang Tags: Research Paper Source Type: research

The Proportion and Prognostic Significance of T-Regulatory Cells in Patients with Gynecological Cancers: A Systematic Review and Meta-Analysis
Conclusions: Compared to controls, proportion of Tregs in PB and tissues was both higher among GCs patients, and it can be considered as a clinical biomarker for screening and prediction of clinical characteristics of GCs patients. But larger researches with rigorous design should be carried to explore the deep mechanisms of Tregs in GCs. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jiali Hu, Xirong Wu, Pengzhu Huang, Fei Teng, Yingmei Wang, Fengxia Xue Tags: Research Paper Source Type: research

Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers
Epigenetic regulation plays an important role in the occurrence, development and treatment of malignant tumors; and a great deal of attention has been paid to the histone methylation level in recent years. As a 230-kD epigenetic regulator, the histone H3 lysine 36 histone (H3K36) methyltransferase SETD2 is a key enzyme of the nuclear receptor SET domain-containing (NSD) family, which is associated with a specific hyperphosphorylated domain, a large subunit of RNA polymerase II (RNAPII), named RNAPII subunit B1 (RPB1), and SETD2 which methylates the ly-36 position of dimethylated histone H3 (H3K36me2) to generate trimethyla...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Rui Chen, Wei-qing Zhao, Cheng Fang, Xin Yang, Mei Ji Tags: Review Source Type: research

Analysis of lncRNA, miRNA and mRNA-associated ceRNA networks and identification of potential drug targets for drug-resistant non-small cell lung cancer
Conclusions: The current study provides a promising therapeutic strategy against the lncRNA-miRNA-mRNA ceRNA regulatory network for NSCLC treatment and deepens our comprehension of the ceRNA regulatory mechanisms related to drug resistance to NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiangzhen Kong, Shousen Hu, Yongliang Yuan, Yue Du, Zijia Zhu, Zhizhen Song, Shanshan Lu, Chang Zhao, Dan Yan Tags: Research Paper Source Type: research

Down-regulation of Long Non-coding RNA LINC01554 in Hepatocellular Cancer and its Clinical Significance
Background: For high morbidity rate but lack of early accurate screening, hepatocellular cancer (HCC) manifests as the fourth leading cause of cancer related death worldwide. Accumulating evidence demonstrated that a series of long noncoding RNA (lncRNA) have strong association with pathogenesis and clinical evaluation of HCC. LINC01554, one kind of lncRNA, has been found specifically enriched in liver tissue. However, the relationship between LINC01554 expression and HCC tumorigenesis remains unclear.Methods: The relative LINC01554 expression was measured in HCC tissues of 138 patients and several HCC cell lines using qua...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yuan Ding, Zhongquan Sun, Sitong Zhang, Yining Chen, Bo Zhou, Guogang Li, Qiang Sun, Dongkai Zhou, Yao Ge, Sheng Yan, Weilin Wang Tags: Research Paper Source Type: research

miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development
TROP2 (trophoblast cell surface antigen 2) overexpression has been reported in many human cancers. The correlation between TROP2 and tumor aggressiveness has implied it could be a prognostic indicator. However, the roles of TROP2 and their underlying mechanisms remain of great interest in head and neck squamous cell carcinoma (HNSCC) biology. In the current study, the prognostic significance of TROP2 in HNSCC archival samples was determined using immunohistochemistry. Quantitative reverse transcriptase PCR (qRT-PCR) was used to measure the phenotypic effects of TROP2 knockdown, miR-488-3p re-expression, and circRNAs expres...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yanru Hao, Dejun Zhang, Yingyuan Guo, Zeming Fu, Duojiao Yu, Guofang Guan Tags: Research Paper Source Type: research

Transcriptional Regulation of Latency-Associated Transcripts (LATs) of Herpes Simplex Viruses
Herpes simplex viruses (HSVs) cause cold sores and genital herpes and can establish lifelong latent infection in neurons. An engineered oncolytic HSV (oHSV) has recently been approved to treat tumors in clinics. HSV latency-associated transcripts (LATs) are associated with the latent infection, but LAT transcriptional regulation was seldom reported. For a better treatment of HSV infection and tumors, here we sequenced the LAT encoding DNA and LAT transcription regulatory region of our recently isolated new strain HSV-1-LXMW and did comparative analysis of the sequences together with those of other four HSV-1 and two HSV-2 ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ying Zhang, Qiang Xin, Jun-Yi Zhang, Ying-Ying Wang, Jun-Ting Cheng, Wen-Qi Cai, Zi-Wen Han, Yang Zhou, Shu-Zhong Cui, Xiao-Chun Peng, Xian-Wang Wang, Zhaowu Ma, Ying Xiang, Xiu-Lan Su, Hong-Wu Xin Tags: Research Paper Source Type: research

Overexpression of Epcam and CD133 Correlates with Poor Prognosis in Dual-phenotype Hepatocellular Carcinoma
Conclusions: These results suggest that DPHCC is associated with significantly lower overall survival than non-DPHCC, and that the poor prognosis among DPHCC patients may be related to the presence of CSCs expressing CD133 and EpCAM. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jie Zhang, Ya-Peng Qi, Ning Ma, Fei Lu, Weng-Feng Gong, Bin Chen, Liang Ma, Jian-Hong Zhong, Bang-De Xiang, Le-Qun Li Tags: Research Paper Source Type: research

Sex Differences and Adverse Effects between Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer
Conclusions: The type of treatment was statistically significant in responding to the treatment and treatment side effects but not in the rate of death. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Theodora Tsiouda, Chrisanthi Sardeli, Konstantinos Porpodis, Maria Pilikidou, Georgios Apostolidis, Krystallia Kyrka, Angeliki Miziou, Konstantina Kyrka, Zoi Tsingerlioti, Souzana Papadopoulou, Anta Heva, Charilaos Koulouris, Dimitrios Giannakidis, Konsta Tags: Research Paper Source Type: research

The LncRNA HOTAIRM1 Promotes Tamoxifen Resistance by Mediating HOXA1 Expression in ER+ Breast Cancer Cells
This study explored the molecular mechanisms of HOTAIRM1 involved in acquired tamoxifen resistance. We showed that HOTAIRM1 and HOXA1 are concurrently up-regulated in tamoxifen-resistant MCF7 (TAMR) cells. Knockdown of HOTAIRM1 down-regulated HOXA1 expression and restored sensitivity to tamoxifen. In addition, the knockdown of HOXA1 showed similar effects, suggesting that the HOTAIRM1/HOXA1 axis regulates tamoxifen resistance. Furthermore, we showed that HOTAIRM1 directly interacts with EZH2 and prevents the PRC2 complex from binding and depositing H3K27me3 on the putative promoter of HOXA1. Together, our findings suggest ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Clara Yuri Kim, Ji Hoon Oh, Ji-Yeon Lee, Myoung Hee Kim Tags: Research Paper Source Type: research

MiR-425 Promotes Migration and Invasion in Bladder Cancer by Targeting Dickkopf 3
Conclusion: Our study indicated that miR-425 promoted the migration and invasion of BC via targeting DKK3. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jin-zhuo Ning, Wei-min Yu, Fan Cheng, Ting Rao, Yuan Ruan Tags: Research Paper Source Type: research

The NF- κ B modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer
miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5p, and downregulation of miR-194-5p expression increases IGF1R and PPFIBP expression, resulting in increased proliferation, invasion and migration of ovarian cancer cells. Moreover, we showed that NF-κB can bind to the promo...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ru Bai, Kaikai Dou, Yang Wu, Yongjing Ma, Jianmin Sun Tags: Research Paper Source Type: research

MiR-186 bidirectionally regulates cisplatin sensitivity of ovarian cancer cells via suppressing targets PIK3R3 and PTEN and upregulating APAF1 expression
Ovarian cancer is a highly lethal malignancy in the female reproductive system. Platinum drugs, represented by cisplatin, are the first-line chemotherapeutic agents for treatment of various malignancies including ovarian cancer, but drug resistance leads to chemotherapy failure. MicroRNAs emerged as promising molecules in reversal of cisplatin resistance. MiR-186 was reported to be downregulated in the cisplatin-resistant ovarian cell lines and miR-186 expression increased cisplatin sensitivity. However, we found the bidirectional regulatory effects of miR-186 on cisplatin sensitivity for the first time that overexpression...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ying Xiang, Ya-Jun Chen, Yun-Bo Yan, Yu Liu, Jiao Qiu, Rui-Qiao Tan, Qing Tian, Li Guan, Shuai-Shuai Niu, Hong-Wu Xin Tags: Research Paper Source Type: research

Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
Conclusion: Collectively, these data highlight a novel anti-tumor mechanism of Niclosamide that involves an interruption of cell metabolism. The finding also indicates a potential for the application of Niclosamide in ovarian carcinoma therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fugen Shangguan, Yan Liu, Li Ma, Guiwu Qu, Qing Lv, Jing An, Shude Yang, Bin Lu, Qizhi Cao Tags: Research Paper Source Type: research

PLOD2 increases resistance of gastric cancer cells to 5-fluorouracil by upregulating BCRP and inhibiting apoptosis
Conclusion: PLOD2 contributed to increasing resistance of gastric cancer cells to 5-fluorouracil by upregulating BCRP and inhibiting apoptosis. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaohui Wang, Jiaojiao Guo, Meng Dai, Tengqi Wang, Tingting Yang, Xuejun Xiao, Qi Tang, Lingli Zhang, Lizhou Jia Tags: Research Paper Source Type: research

Arsenic trioxide induces autophagic degradation of the FLT3-ITD mutated protein in FLT3-ITD acute myeloid leukemia cells
In this study, we explored the therapeutic efficacy of ATO treatment in a mouse model bearing FLT3-ITD AML and found that ATO significantly reduced the leukemic burden in bone marrow and spleen. We also found that autophagy was responsible for, at least in part, the degradation of the FLT3-ITD protein by ATO. After ATO treatment, MV4-11 cells showed complete autophagic flux. The autophagy inhibitor bafilomycin A or down-regulation of the key autophagy genes Atg5 and Atg7 reversed the FLT3 degradation induced by ATO. We also found that p62/SQSTM1 delivered FLT3-ITD proteins to the lysosome, where they were subsequently degr...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiao-Jian Liu, Li-Na Wang, Zu-Han Zhang, Cong Liang, Yu Li, Jie-Si Luo, Chun-Jin Peng, Xiao-Li Zhang, Zhi-Yong Ke, Li-Bin Huang, Yan-Lai Tang, Xue-Qun Luo Tags: Research Paper Source Type: research

Multicenter Validation Study of the American Joint Commission on Cancer (8th Edition) for Gastric Cancer: Proposal for a Simplified and Improved TNM Staging System
Conclusion: The prognostic prediction of the eighth edition of the AJCC TNM classification is superior to that of the seventh edition. However, it remains associated with some stage migration. The iTNM staging system permits simplification and slightly better prognostic prediction. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jian-Xian Lin, Jacopo Desiderio, Jun-Peng Lin, Wei Wang, Ru-Hong Tu, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Chao-Hui Zheng, Zhi-wei Zhou, Amilcare Parisi, Chang-Ming Huang Tags: Research Paper Source Type: research

lncRNA SNHG3 acts as a novel Tumor Suppressor and regulates Tumor Proliferation and Metastasis via AKT/mTOR/ERK pathway in Papillary Thyroid Carcinoma
The incidence of papillary thyroid carcinoma (PTC) has been increased rapidly in recent decades. Long noncoding RNAs (lncRNA) are a class of non-protein-coding transcripts and play critical roles in regulating gene expression and influence biological behaviors of multiple cancers, including PTC. Here, we discovered that lncRNA SNHG3 was significantly downregulated in PTC tissues and cell lines, the expression of SNHG3 was negatively correlated with the TNM stage and poor prognosis of PTC patients. Functional studies illustrated that the depletion of SNHG3 via CRISPR/Cas9 technology promoted the proliferation, migration and...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yu Duan, Zhiyong Wang, Lijuan Xu, Li Sun, Hairong Song, Huiqing Yin, Fucheng He Tags: Research Paper Source Type: research

Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors
Alternative splicing facilitates the splicing of precursor RNA into different isoforms. Alternatively spliced transcripts often exhibit antagonistic functions or differential temporal or spatial expression patterns. There is increasing evidence that alternative splicing, especially by the serine-arginine rich (SR) protein family, leads to abnormal expression patterns and is closely related to the development of cancer. SRSF3, also known as SRp20, is a splicing factor. Through alternative splicing, it plays important roles in regulating various biological functions, such as cell cycle, cell proliferation, migration and inva...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yingying Che, Lin Fu Tags: Review Source Type: research

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children
Hepatoblastoma is one of the malignant liver tumors in children. However, genetic mechanisms underpinning the initiation of hepatoblastoma remain largely unclear. The previous study showed that lin-28 homolog B (LIN28B) might play a role in the development of hepatoblastoma. To detect the association between LIN28B gene polymorphisms and hepatoblastoma risk in Chinese children, we conducted a five-center case-control study of 275 hepatoblastoma patients and 1018 cancer-free controls. Four potentially functional polymorphisms were genotyped using the Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were u...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhonghua Yang, Yuyao Deng, Keren Zhang, Yuzuo Bai, Jinhong Zhu, Jiao Zhang, Yijuan Xin, Li Li, Jing He, Weilin Wang Tags: Research Paper Source Type: research