The Prognostic Value of aspartate aminotransferase to lymphocyte ratio and systemic immune-inflammation index for Overall Survival of Hepatocellular Carcinoma Patients Treated with palliative Treatments
Background: Lymphocytes were reported to play a significant part in host anticancer immune responses and influence tumour prognosis. Few studies have focused on the prognostic values of aspartate aminotransferase (AST) to lymphocyte ratio (ALRI), aspartate aminotransferase to platelet count ratio index (APRI) and systemic immune-inflammation index (SII) in hepatocellular carcinoma (HCC) treated with palliative treatments.Methods: Five hundred and ninety-eight HCC patients treated with palliative therapies were retrospectively analysed. We randomly assigned patients into the training cohort (429 patients) and the validation...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Li-Yun Zhao, Dong-Dong Yang, Xiao-Kun Ma, Meng-Meng Liu, Dong-Hao Wu, Xiao-Ping Zhang, Dan-Yun Ruan, Jin-Xiang Lin, Jing-Yun Wen, Jie Chen, Qu Lin, Min Dong, Jing-Jing Qi, Pei-Shan Hu, Zhao-Lei Zeng, Zhan-Hong Chen, Xiang-Yuan Wu Tags: Research Paper Source Type: research

On The Role of Myelin and Lymphocyte Protein (MAL) In Cancer: A Puzzle With Two Faces
Myelin and lymphocyte protein (MAL) is an integral membrane protein constituent of lipid rafts, and it is implicated in apical transport of proteins in polarized epithelial cells. However, beyond the involvement of MAL in apical sorting and as its function as a raft stabilizer, it is still not totally clear how MAL participates in cell proliferating processes. More controversial and interesting is the fact that MAL has been implicated in carcinogenesis in two opposite ways. First, this protein is overexpressed in ovarian cancer and some kinds of lymphomas where it seems to favor cancer progression. Conversely, it has been ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Roberto Lara-Lemus Tags: Review Source Type: research

PPAR α gene is a diagnostic and prognostic biomarker in clear cell renal cell carcinoma by integrated bioinformatics analysis
In conclusion, PPARα expression was decreased in ccRCC tumors. Lower expression of PPARα is closely correlated with poorer survival. It can be used as a clinically diagnosis and prognostic biomarker in ccRCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yongwen Luo, Liang Chen, Gang Wang, Guofeng Qian, Xuefeng Liu, Yu Xiao, Xinghuan Wang, Kaiyu Qian Tags: Research Paper Source Type: research

Clinicopathological Significance of BRAFV600E Mutation in Colorectal Cancer: An Updated Meta-Analysis
Background and Aims: Numerous studies have identified BRAFV600E mutation as a predictive factor of anti-EGFR antibodies in colorectal cancer (CRC). However, the association between BRAFV600E mutation and clinicopathological features remains unclear. Therefore, we aimed to conduct an updated and comprehensive meta-analysis to evaluate the above issues.Methods: We performed a systematic literature search from PubMed, Web of Science, Embase, and PMC database examining the association between BRAFV600E mutation and clinicopathological features in CRC patients. Odds ratio with 95% confidence interval were used to estimate the e...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jianhua Wang, Jiajia Shen, Chi Huang, Meng Cao, Lizong Shen Tags: Research Paper Source Type: research

Proteomic Analysis of the Molecular Mechanism of Lovastatin Inhibiting the Growth of Nasopharyngeal Carcinoma Cells
Metabolic abnormalities are one of the essential features of tumors. Increasingly more studies have shown that lovastatin, a lipid-reducing drug, has visible inhibitory effects on tumors, but it has not been reported in nasopharyngeal carcinoma. In this paper, we explored the effects of lovastatin on the growth of nasopharyngeal carcinoma cells and its possible molecular mechanisms. After treating nasopharyngeal carcinoma cells with different concentrations of lovastatin, we found that lovastatin can inhibit the growth of nasopharyngeal carcinoma in a time- and dose-dependent manner. To explore the molecular mechanism of h...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yongzhen Mo, Yumin Wang, Fang Xiong, Xiaolu Ge, Zheng Li, Xiayu Li, Yong Li, Xiaoling Li, Wei Xiong, Guiyuan Li, Zhaoyang Zeng, Can Guo Tags: Research Paper Source Type: research

Is Routine Subcarinal Lymph Node Dissection Necessary in Superficial Esophageal Squamous Cell Carcinoma? A Propensity Score Matching Analysis
Conclusion: Subcarinal lymph node dissection was not beneficial and could be omitted in superficial ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Han Tang, Lijie Tan, Hao Wang, Yaxing Shen, Jun Yin, Yong Fang, Qun Wang Tags: Research Paper Source Type: research

Co-delivery of Cyclopamine and Doxorubicin Mediated by Bovine Serum Albumin Nanoparticles Reverses Doxorubicin Resistance in Breast Cancer by Down-regulating P-glycoprotein Expression
In this study, a novel drug delivery system based on bovine serum albumin nanoparticles (BSA NPs) was successfully developed. Doxorubicin (DOX) and cyclopamine (CYC), a potential anti-cancer agent that inhibits the hedgehog signaling pathway were entrapped into BSA NPs through electrostatic interactions and hydrophobic interactions, respectively. Rather than simple combination of two different chemotherapeutics, the CYC also increased the intracellular DOX accumulation by decreasing the expression of P-glycoprotein (P-gp), which could thus reverse the DOX resistance. Tumor-targeting property of nanoparticles was the prereq...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yong-lin Lu, Ya-bin Ma, Chan Feng, Dong-lei Zhu, Jie Liu, Lv Chen, Shu-jing Liang, Chun-yan Dong Tags: Research Paper Source Type: research

Radical Nephrectomy with or without Lymph Node Dissection for pT3 Renal Cell Carcinoma: A Propensity Score-based Analysis
Conclusion: RN with LND cannot improve the PFS, CSS, or OS for pT3 renal cell carcinoma patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Pin Li, Cheng Peng, Liangyou Gu, Yongpeng Xie, Wenyuan Nie, Yu Zhang, Yundong Xuan, Donglai Shen, Songliang Du, Lu Tang, Yuanxin Yao, Yang Fan, Xin Ma, Xu Zhang Tags: Research Paper Source Type: research

Impact of Tumor Site on Lymph Node Status and Survival in Colon Cancer
Objective Our objective was to explore the impact of tumor sites on lymph node (LN) status and prognosis in non-distant metastasis colon cancer after radical operation.Methods Surveillance, epidemiology, and end results (SEER) database was used to identify 124, 836 early-stage colon cancer patients between 1988 and 2010, treated with radical surgery with a known tumor site. Seven tumor sites were defined as ascending, hepatic, cecum, transverse, descending, splenic, and sigmoid colons by the anatomical location. The associations of tumor site and LN status, including adequate (≥12) LN harvest and LN positivity, were exa...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yayun Xie, Yu Huang, Qi Ruan, Haolu Wang, Xiaowen Liang, Zhiqian Hu, Xinxing Li Tags: Research Paper Source Type: research

Intra-platelet Serotonin as a Biomarker in HCC Recurrence: When Time Matters
(Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bibek Aryal, Munekazu Yamakuchi, Teruto Hashiguchi, Yutaka Imoto Tags: Commentary Source Type: research

Prognostic Value of Long Noncoding RNA CRNDE as a Novel Biomarker in Solid Cancers: An Updated Systematic Review and Meta-Analysis
Background: Long noncoding RNA colorectal neoplasia differentially expressed (CRNDE) has been reported to exhibit a potential oncogenic role in the development of human cancers. However, the clinical value of CRNDE expression in various cancers still remains unclear. Herein, we conducted a meta-analysis to investigate the association between CRNDE and clinical outcomes in solid cancers.Methods: A systematic search was performed though the PubMed, EMBASE, Web of Science, Ovid, Cochrane library, CNKI and WanFang databases for eligible studies on clinical values of CRNDE in solid cancers. The pooled hazard ratios (HRs) or odd...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yu Zhou, Rui Wang, Tian Xu, Ping Xie, Yun Zhang, Aifeng Zhang, Xiaojie Wang, Chong Yang, Hongji Yang, Shikai Zhu Tags: Research Paper Source Type: research

Clinicopathological Analysis of HIF-1alpha and TERT on Survival Outcome in Glioblastoma Patients: A Prospective, Single Institution Study
Glioblastoma multiforme is a highly malignant and aggressive primary brain tumor with a dismal prognosis. We studied the association of immunohistochemical expression of hypoxia inducible factor-1 alpha (HIF-1α), telomerase reverse transcriptase (TERT), isocitrate dehydrogenase 1 (IDH1) and tumor protein p53 with overall survival (OS) in glioblastoma patients uniformly treated by standard of care, with adequate follow-up. In 87 patient samples studied, 59 were male and 28 were female. The median age was 55 years. The median follow-up was 27.7 months and the median overall survival was 14.9 months. Nuclear staining of...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mahadev Potharaju, Anugraha Mathavan, Balamurugan Mangaleswaran, Sushama Patil, Reginald John, Siddhartha Ghosh, Chandrasekhar Kalavakonda, Mitra Ghosh, Rama Shanker Verma Tags: Research Paper Source Type: research

The Advancement of Long Non-Coding RNAs in Cholangiocarcinoma Development
Cholangiocarcinoma (CCA) is a malignancy with increasing incidence in recent years. CCA patients are usually diagnosed at advanced stage due to lack of apparent symptoms and specifically diagnostic markers. Nowadays, surgical removal is the only effective method for CCA whereas overall 5-year-survival rate keeps around 10%. Long-noncoding RNA (lncRNA), a subtype of noncoding RNA, is widely studied to be abnormally expressed in multiple cancers including CCA. LncRNA can promote proliferation, migration, invasion and inhibit apoptosis of CCA. Moreover, lncRNA is negatively correlated with the prognosis of CCA. LncRNA may con...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fengru Jiang, Xiaofeng Ling Tags: Review Source Type: research

Cordycepin Induces Apoptosis and G2/M Phase Arrest through the ERK Pathways in Esophageal Cancer Cells
This study focuses on the anticancer properties of cordycepin that target esophageal cancer and reveals molecular aspects underlying these effects. In our CCK-8 assays and colony formation assays, cordycepin significantly suppressed esophageal cancer cell proliferation. Moreover, cordycepin induced chromatin condensation in esophageal cancer cells and significantly increased the number of apoptotic cells through activation of caspase cascades, apoptotic signaling, and the regulation of Bcl-2 family members. Cell cycle assays showed that cordycepin altered cyclin-dependent kinase1 and cyclinB1 expression, which resulted in ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jia-Cheng Xu, Xue-Ping Zhou, Xu-An Wang, Mei-Dong Xu, Tao Chen, Tian-Yin Chen, Ping-Hong Zhou, Yi-Qun Zhang Tags: Research Paper Source Type: research

Advances in the Regulatory Effects of Bioactive Peptides on Metabolic Signaling Pathways in Tumor Cells
Changes in cell metabolism are an important feature of tumors that has always been an intense topic of study, particularly in regard to whether metabolic disorders are a cause or an effect of tumorigenesis. Studies have shown that the processes underlying metabolic changes in tumors involve the activation of protooncogenes and the inactivation of cancer suppressor genes, as well as changes in metabolic flux in cells due to the abnormal activation of signaling pathways that modulate metabolic enzymes and/or metabolic regulatory proteins at several levels, including transfer and posttranslational modification. Thus, the repa...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hongwei Cui, Wenyan Han, Junyao Zhang, Zhihui Zhang, Xiulan Su Tags: Review Source Type: research

Role of p53 Family Proteins in Metformin Anti-Cancer Activities
Metformin has been used as therapy for type 2 diabetes for many years. Clinical and basic evidence as indicated that metformin has anti-cancer activities. It has been well-established that metformin activates AMP-activated protein kinase (AMPK), which in turn regulates energy homeostasis. However, the mechanistic aspects of metformin anti-cancer activity remain elusive. p53 family proteins, including p53, p63 and p73, have diverse biological functions, including regulation of cell growth, survival, development, senescence and aging. In this review, we highlight the evidence and mechanisms by which metformin inhibits cancer...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yong Yi, Wenhua Zhang, Jianqiao Yi, Zhi-Xiong Xiao Tags: Review Source Type: research

A Nomogram Predicting Lymph Node Metastasis in T1 Breast Cancer based on the Surveillance, Epidemiology, and End Results Program
Conclusions: A better understanding of the clinicopathological characteristics of T1 breast cancer patients might important for assessing their lymph node status. The nomogram developed here, if further validated in other large cohorts, might provide additional information regarding lymph node metastasis. Together with sentinel lymph node biopsy, this nomogram can help comprehensively predict lymph node metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ya-Xin Zhao, Yi-Rong Liu, Shao Xie, Yi-Zhou Jiang, Zhi-Ming Shao Tags: Research Paper Source Type: research

The postoperative lean body mass loss at one month leads to a poor survival in patients with locally advanced gastric cancer
Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuvant chemotherapy with S-1.Methods: The recurrence free survival (RFS) overall survival (OS) and were examined in 115 patients who underwent curative gastrectomy and were pathologically diagnosed with stage II or III gastric cancer and who received postoperative adjuvant chemotherapy with S-1 between May 2011 a...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Toru Aoyama, Takaki Yoshikawa, Yukio Maezawa, Kazuki Kano, Masakatsu Numata, Kentaro Hara, Keisuke Komori, Takanobu Yamada, Tsutomu Hayashi, Tsutomu Sato, Hiroshi Tamagawa, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takashi Tags: Research Paper Source Type: research

Predictors of the survival of patients with chondrosarcoma of bone and metastatic disease at diagnosis
Purpose: Chondrosarcoma with metastatic disease has a very poor prognosis. However, the prognosis and potential prognostic factors of patients with primary chondrosarcoma of bone and metastasis at presentation have not been documented because of its rarity. Therefore, we examined the prognosis of this special cohort and identify possible prognostic factors.Methods: The Surveillance, Epidemiology, and End Results (SEER) program database was used to identify patients with primary chondrosarcoma of bone and metastatic disease at diagnosis from 2000 to 2013. The prognostic analysis was performed using the Kaplan-Meier method a...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhan Wang, Genlian Chen, Xiaowei Chen, Xin Huang, Meng Liu, Weibo Pan, Xiaobo Yan, Nong Lin, Zhaoming Ye Tags: Research Paper Source Type: research

4-1BBL has a Possible Role in Mediating Castration-Resistant Conversion of Prostate Cancer via Up-Regulation of Androgen Receptor
4-1BB ligand (4-1BBL) was a transmembrane glycoprotein belonging to the tumor necrosis factor family. It was expressed on activated T lymphocytes and function as a co-stimulatory molecule via cross-linking with 4-1BB (a.k.a, CD137). In addition to its role in immune regulation, 4-1BBL transmitted signals into the cells on which it was expressed (reverse signaling). 4-1BBL represented a promising target for enhancing antitumor immune responses. Recent studies indicated that 4-1BBL also expressed in non-immune cells and possessed different functions in various types of cells. Here, we reported that 4-1BBL didn't express in n...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hengcheng Zhu, Min Wang, Yang Du, Xiuheng Liu, Xiaodong Weng, Chenglong Li Tags: Research Paper Source Type: research

MiR-199a-5p suppresses non-small cell lung cancer via targeting MAP3K11
MicroRNAs (miRNAs) comprise a class of short, non-coding RNAs that directly target 3′UTR of mRNA, causing subsequent degradation or suppression of translation. Here, we verified that miR-199a-5p was significantly down-regulated in mouse NSCLC tissues and human patient samples. To further study the function of miR-199a-5p, lentivirus system was adopted to construct stably over-expressing miR-199a-5p A549, SPC-A1 and H1299 cell lines. Then, miR-199a-5p played a tumor suppression role via directly targeting MAP3K11 gene in non-small cell lung cancer (NSCLC). Elevated miR-199a-5p suppressed cell proliferation and arreste...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yanli Li, Detao Wang, Xue Li, Yang Shao, Yanyun He, Huansha Yu, Zhongliang Ma Tags: Research Paper Source Type: research

SNAI2 3'untranslated region promotes the invasion of ovarian cancer cells by inducing MARCKS expression
Conclusion: In conclusion, our study demonstrated that SNAI2-3'UTR cloud promote the invasion of ovarian cancer cells by upregulating MARCKS expression, which proposed a new mechanism by which SNAI2 contributed to progression of ovarian cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jun Li, Jieyu Wang, Huiran Yue, Xin Lu Tags: Research Paper Source Type: research

Regulatory Molecules and Corresponding Processes of BCR-ABL Protein Degradation
The BCR-ABL fusion protein with strong tyrosine kinase activity is one of the molecular biological bases of leukemia. Imatinib (Gleevec), a specific targeted drug for the treatment of chronic myeloid leukemia (CML), was developed for inhibiting the kinase activity of the BCR-ABL fusion protein. Despite the positive clinical efficacy of imatinib, the proportion of imatinib resistance has gradually increased. The main reason for the resistance is a decrease in sensitivity to imatinib caused by mutation or amplification of the BCR-ABL gene. In response to this phenomenon, the new generation of tyrosine kinase inhibitors (TKIs...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Han-Qing Zhu, Feng-Hou Gao Tags: Review Source Type: research

Role of Autophagy in Renal Cancer
Autophagy is a highly conserved catabolic process with critical functions in maintenance of cellular homeostasis under normal growth conditions and in preservation of cell viability under stress. The role of autophagy in cancer is dual-sided. Autophagy-deficient cells are often more tumorigenic than their wild type counterparts in association with DNA damage accumulation, oxidative stress. At the same time, autophagy is a major cell survival mechanism. In recent years, it has been well demonstrated that autophagy may have relation with renal cell carcinoma (RCC). This review focuses on the research progress in relation bet...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Cao, Peng Bai Tags: Review Source Type: research

CK7 expression associates with the location, differentiation, lymph node metastasis, and the Dukes' stage of primary colorectal cancers
Conclusion: CRC cells expressing CK7 may have strong invasive and metastatic abilities. Some metastasis-related morphological characteristics in CRCs including the invasion front, micropapillary pattern, tumor emboli, and single stromal PGCCs associated with CK7 positive expression. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fei Fei, Chunyuan Li, Yuan Cao, Kai Liu, Jiaxing Du, Yanjun Gu, Xinlu Wang, Yuwei Li, Shiwu Zhang Tags: Research Paper Source Type: research

Clustered microRNAs hsa-miR-221-3p/hsa-miR-222-3p and their targeted genes might be prognostic predictors for hepatocellular carcinoma
Conclusion: Has-miR-222-3p and target genes, especially CBFB, UBE2N, may serve as prognostic predictors for HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiangkun Wang, Xiwen Liao, Ketuan Huang, Xianmin Zeng, Zhengqian Liu, Xin Zhou, Tingdong Yu, Chengkun Yang, Long Yu, Qiaoqi Wang, Chuangye Han, Guangzhi Zhu, Xinping Ye, Tao Peng Tags: Research Paper Source Type: research

Metastatic lymph node ratio as a prognostic indicator in patients with stage IV colon cancer undergoing resection
Conclusion: The LNR can be used as an independent prognostic factor in patients with stage IV colon cancer patients undergoing resection. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chang Jiang, Fang Wang, Guifang Guo, Jun Dong, Shousheng Liu, Wenzhuo He, Bei Zhang, Liangping Xia Tags: Research Paper Source Type: research

The oncogenic potential of PRR11 gene in Tongue Squamous Cell Carcinoma cells
Conclusion: These results suggested that PRR11 promoted cell proliferation by regulating the expressions of p21, p27, CDK2 and Cyclin A to facilitate S/G phase transition in TSCC cells. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chunyang Wang, Liang Yu, Xianyue Ren, Tong Wu, Xijuan Chen, Yulei Huang, Bin Cheng Tags: Research Paper Source Type: research

Identifying miRNA-mRNA Pairs and Novel miRNAs from Hepatocelluar Carcinoma miRNomes and TCGA Database
In conclusion, the miRNA/mRNA pairs identified in our study may have some potential values to be further studied in progression, diagnosis and prognosis of HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ping Wu, Yunyue Xiao, Tao Guo, Yitao Wang, Shanshan Liao, Lang Chen, Zhisu Liu Tags: Research Paper Source Type: research

Pathologic and prognostic impacts of FGFR2 amplification in gastric cancer: a meta-analysis and systemic review
Fibroblast growth factor receptor-2 (FGFR2) gene is amplified in up to 15% of patients with gastric cancer (GC). However, the prognostic significance of FGFR2 amplification has been controversial. This meta-analysis was conducted to evaluate the clinicopathological impacts of FGFR2 amplification in patients with GC. We performed a systematic computerized search of the electronic databases of PubMed, PMC, EMBASE, Web of Science, and Google Scholar and selected studies assessing the correlation of FGFR2 amplification with pathologic features and/or prognosis in gastric adenocarcinoma. From eight studies, 2,377 patients were ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hyeong Su Kim, Jung Han Kim, Hyun Joo Jang Tags: Research Paper Source Type: research

Prognostic Significance of Hematological Markers for Patients with Nasopharyngeal Carcinoma: A Meta-analysis
Purpose: Hematological parameters are considered to be associated with prognosis in various cancers. We designed a meta-analysis to evaluate the prognostic significance of hematological parameters, including the neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CRP/ALB), lymphocyte-to-monocyte ratio (LMR), plasma fibrinogen level, Glasgow prognostic score (GPS), platelet-to-lymphocyte ratio (PLR) and high-density lipoprotein cholesterol (HDL-C) level, on clinical outcomes in nasopharyngeal carcinoma (NPC).Methods: Relevant studies published prior to February 2018 were identified in the PubMed, Web of ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shanshan Yang, Kun Zhao, Xiao Ding, Haiping Jiang, Haijun Lu Tags: Research Paper Source Type: research

Blocking the PD-1/PD-L1 axis in dendritic cell-stimulated Cytokine-Induced Killer Cells with pembrolizumab enhances their therapeutic effects against hepatocellular carcinoma
Immune checkpoint therapies for cancer, like the anti-programmed cell death 1 (PD-1) agent pembrolizumab, have gained considerable attention. However, the use of immune checkpoint inhibitors in the context of adoptive immunotherapy is poorly characterized. We investigated the therapeutic efficacy of dendritic cell-stimulated CIK (DC-CIK) cells pretreated with pembrolizumab against hepatocellular carcinoma (HCC) in cytotoxicity assay in vitro and in a nude mouse xenograft model. We used time-lapse imaging to investigate tumor killing. We also performed a survival analysis based on lymphocyte subpopulation-specific mRNA sign...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wan Zhang, Zhenghui Song, Jianpeng Xiao, Xinhui Liu, Yue Luo, Zike Yang, Rongcheng Luo, Aimin Li Tags: Research Paper Source Type: research

Developing a multivariable normal tissue complication probability model to predict late rectal bleeding following intensity-modulated radiation therapy
Conclusions: A LASSO-based multivariable NTCP model comprising three important predictors (platelet count, risk group and V65) was established to predict the incidence of grade 2+ late rectal bleeding after IMRT. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chun-Chieh Huang, Pei-Ju Chao, Shih-Sian Guo, Chong-Jong Wang, Hao-Lun Luo, Yu-Li Su, Tsair-Fwu Lee, Fu-Min Fang Tags: Research Paper Source Type: research

Involvement of endothelial nitric oxide synthase gene variants in the aggressiveness of uterine cervical cancer
In conclusion, although eNOS SNPs rs2070744 and rs1799983 do not display significant associations with cervical carcinogenesis and patient survival, cervical cancer patients with genotypes TC/CC in rs2070744 carry less risk of advanced stage, parametrium invasion and pelvic lymph node metastasis in Taiwan. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wei-Chen Hung, Ting-Feng Wu, Soo-Cheen Ng, Yueh ‐ Chun Lee, Huang-Pin Shen, Shun-Fa Yang, Po-Hui Wang Tags: Research Paper Source Type: research

Neuroblastoma by chance
Neuroblastoma is a pediatric cancer of embryonic origin from neural crest cells. Neuroblastoma has a great medical and social impact because it is occurring with major frequency in pre-scholar age with metastatic disease showing less than 40% of survival at 5-years. In children, metastatic neuroblastoma has very few recurrent mutations but several chromosome structural copy variations. The tumorigenesis of neuroblastoma is still largely unknown; however recently, genomic wide association studies have shown that several gene allelic variants are associated with neuroblastoma predisposition. Many of these gene variants are r...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Gian Paolo Tonini Tags: Editorial Source Type: research

Biologic Mechanisms Linked to Prognosis in Ovarian Cancer that May Be Affected by Aging
The increase of both life expectancy of the Western industrialized population and cancer incidence with aging is expected to result in a rapid expansion of the elderly cancer population, including patients with epithelial ovarian cancer (EOC). Although the survival of patients with EOC has generally improved over the past three decades, this progress has yet to provide benefits for elderly patients. Compared with young age, advanced age has been reported as an adverse prognostic factor influencing EOC. However, contradicting results have been obtained, and the mechanisms underlying this observation are poorly defined. Few ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hye Sook Chon, Marina Sehovic, Douglas Marchion, Christine Walko, Yin Xiong, Martine Extermann Tags: Review Source Type: research

High WNT6 expression indicates unfavorable survival outcome for patients with colorectal liver metastasis after liver resection
Conclusions: High expression of WNT6 was associated with unfavorable oncologic prognosis in patients with CRLM undergoing liver resection. Detection of WNT6 expression may be valuable for guiding postoperative treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jianhong Peng, Yixin Zhao, Qiuyun Luo, Hao Chen, Wenhua Fan, Zhizhong Pan, Xueping Wang, Lin Zhang Tags: Research Paper Source Type: research

MicroRNA-101-3p advances cisplatin sensitivity in bladder urothelial carcinoma through targeted silencing EZH2
Conclusion: The expression of miR-101-3p is positively related to CDDP sensitivity of BUC, miR-101-3p advances sensitivity of BUC to CDDP through targeted silencing EZH2. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bo Li, Dalong Xie, Hui Zhang Tags: Research Paper Source Type: research

The impact of Ki-67 in the context of multidisciplinary care in primary inflammatory breast cancer
Background: Research on the prognostic or predictive value of Ki-67 among patients with inflammatory breast cancer (IBC) is limited.Methods: Using the comprehensive database of the Morgan Welch Inflammatory Breast Cancer Research Program at MD Anderson Cancer Center, we identified a cohort of breast cancer patients who were diagnosed with IBC between 1992 and 2012. Distributions of survival outcomes were estimated by the Kaplan-Meier method and compared by log-rank tests and Cox models.Results: Among a total of 257 patients with stage III IBC, the mean percentage of tumor cells that stained positive for Ki-67 was 48%, (ran...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jing Ning, Tamer M Fouad, Heather Lin, Aysegul A Sahin, Anthony Lucci, Wendy A. Woodward, Savitri Krishnamurthy, Debu Tripathy, Naoto T. Ueno, Yu Shen Tags: Research Paper Source Type: research

Tracking knowledge evolution, hotspots and future directions of emerging technologies in cancers research: a bibliometrics review
This study also provides researchers with panoramic knowledge of this field, as well as research hotspots and future directions. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaoyu Wang, Jingjing Guo, Dongxiao Gu, Ying Yang, Xuejie Yang, Keyu Zhu Tags: Review Source Type: research

Application of p16/Ki-67 dual-staining cytology in cervical cancers
Cytology-based Papanicolaou test on and primary HPV screening have been widely used in the identification of cervical cancer and precancerous lesions, which is of great significance for the prevention and treatment of cervical cancer. Patients diagnosed as ASCUS/LSIL usually need follow-up because some of them may develop into CIN2+. The consequences of women positive for HPV vary from person to person; some of them may progress into cervical dysplasia, reversible forms of precancerous lesions, and eventually invasive cervical cancer. Therefore, it is necessary to establish an effective biomarker to triage different patien...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Li Yu, Lingyan Fei, Xubin Liu, Xufang Pi, Liantang Wang, Shangwu Chen Tags: Review Source Type: research

Marital Status and Survival in Patients with Penile Cancer
Purpose: We aimed to reveal the effects of marital status on survival outcomes in patients with penile cancer.Methods: Patients with penile cancer who were diagnosed between 2004 and 2015 were identified by using the Surveillance, Epidemiology and End Results (SEER) database. Kaplan-Meier and Cox regressions were used to analyse the effects of marital status on overall survival (OS) and cancer-specific survival (CSS).Results: Among 3,195 eligible patients with penile cancer, 1,951 (61.1%) patients were married, 365 (11.4%) were divorced or separated, 327 (10.2%) were widowed and 552 (17.3%) were single. The widowed patient...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Weipu Mao, Ziwei Zhang, Xin Huang, Jie Fan, Jiang Geng Tags: Research Paper Source Type: research

SRPX2 and RAB31 are effective prognostic biomarkers in pancreatic cancer
Conclusions: The combination of SRPX2 and RAB31 can be important markers for the prognosis of pancreatic cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hao Li, Shi-Rong Zhang, Hua-Xiang Xu, Wen-Quan Wang, Shuo Li, Tian-Jiao Li, Quan-Xing Ni, Xian-Jun Yu, Liang Liu, Chun-Tao Wu Tags: Research Paper Source Type: research

Relationship of prognostic nutritional index with prognosis of gastrointestinal stromal tumors
This study enrolled 431 GIST patients who underwent curative resection from January 2000 to December 2012. A receiver operating characteristic (ROC) curve analysis was used to identify the cutoff value of PNI, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). Survival curves were produced using the Kaplan-Meier method and were compared using a log-rank test. The Cox proportional hazards model was used to identify independent prognostic factors.Results: Of the 431 patients, 209 (48.5%) were male and 222 (51.5%) were female. The median age was 56 (range 20-80 years old). The PNI cutoff value was 47...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jianyi Sun, Ying Mei, Qiutao Zhu, Chunhui Shou, Welda E.H. Tjhoi, Weili Yang, Hang Yu, Qing Zhang, Xiaosun Liu, Jiren Yu Tags: Research Paper Source Type: research

The Diagnostic Value of Serum IGFBP7 in Patients with Esophageal Squamous Cell Carcinoma
Esophageal squamous cell cancer (ESCC) is one of the leading malignant cancer in the world and especially in China with high incidence and mortality. The exploration of novel serum biomarkers is required for early detection of ESCC. We investigated the diagnostic value of serum insulin like growth factor binding protein 7 (IGFBP7) in ESCC, evaluating its potential to improve the diagnosis of ESCC. The serum samples of 106 patients with ESCC and 107 normal controls were tested by enzyme-linked immunosorbent assay (ELISA). The levels of IGFBP7 in ESCC group were significantly higher than that in normal controls, compared by ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xinyi Huang, Chaoqun Hong, Yuhui Peng, Shihan Yang, Lisheng Huang, Cantong Liu, Liuyi Chen, Lingyu Chu, Liyan Xu, Yiwei Xu Tags: Research Paper Source Type: research

The Role of the Slit/Robo Signaling Pathway
The Slit family is a family of secreted proteins that play important roles in various physiologic and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first identified in the nervous system, where it functions in neuronal axon guidance; nevertheless, an increasing number of studies have shown that Slit/Robo signaling even regulates other activities, such as angiogenesis, inflammatory cell chemotaxis, tumor cell migration and metastasis. Although the precise role of the ligand-receptor in organisms has been obscure and the conclusions drawn are sometimes paradoxical, tremendous advances in ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mingfu Tong, Tie Jun, Yongzhan Nie, Jianyu Hao, Daiming Fan Tags: Review Source Type: research

CBX2 Regulates Proliferation and Apoptosis via the Phosphorylation of YAP in Hepatocellular Carcinoma
In conclusion, CBX2 could be a potential target for HCC anticancer treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jiakai Mao, Yu Tian, Chengye Wang, Keqiu Jiang, Rui Li, Yifan Yao, Rixin Zhang, Deguang Sun, Rui Liang, Zhenming Gao, Qi Wang, Liming Wang Tags: Research Paper Source Type: research

Dysregulation of MiR-519d Affects Oral Squamous Cell Carcinoma Invasion and Metastasis by Targeting MMP3
In this study, we found that miR-519d was significantly downregulated in OSCC tissues and cell lines compared with normal oral mucosae and normal oral epithelial cells. Importantly, downregulation of miR-519d was closely correlated with the lymph node metastasis, advanced tumor stage and poor overall survival of OSCC patients. Furthermore, miR-519d significantly inhibited the migration and invasion of OSCC cells. Using bioinformatics and biological approaches, we showed that miR-519d directly targeted matrix metalloproteinase-3 (MMP3), which might account for the underlying mechanism involved in the miR-519d mediated suppr...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yu Jin, Yuexiu Li, Xin Wang, Ya Yang Tags: Research Paper Source Type: research

MiR-940 inhibits TGF- β -induced epithelial-mesenchymal transition and cell invasion by targeting Snail in non-small cell lung cancer
Increased evidence reveals that miR-940 inhibits the migration and invasion of cancer cells. Considering transforming growth factor β (TGF-β) signaling is crucial to cellular epithelial-mesenchymal transition (EMT) process and metastasis of cancer, it is in urgent to explore whether and how miR-940 plays an essential role in regulating TGF-β-induced EMT in lung cancer progression. In the present study, we observed a reciprocal expression with down-regulated miR-940 and up-regulated Snail mRNA in non-small-cell lung cancer (NSCLC) tissues. we further found that the expression of miR-940 was decreased in NSCLC...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Kanqiu Jiang, Ting Zhao, Mingjing Shen, Fuquan Zhang, Shanzhou Duan, Zhe Lei, Yongbing Chen Tags: Research Paper Source Type: research

miR-1226-3p Promotes Sorafenib Sensitivity of Hepatocellular Carcinoma via Downregulation of DUSP4 Expression
Conclusions: miR-1226-3p promotes sorafenib sensitivity of HCC through downregulation of DUSP4 expression, and targeting miR-1226-3p may be a novel therapeutic strategy for overcoming sorafenib resistance. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xianqing Chen, Wenliang Tan, Wenxin Li, Wenda Li, Sicong Zhu, Jinyi Zhong, Changzhen Shang, Yajin Chen Tags: Research Paper Source Type: research