β -elemene enhances the antitumor activity of erlotinib by inducing apoptosis through AMPK and MAPK pathways in TKI-resistant H1975 lung cancer cells
In this study, the NCI-H1975 cell line harboring double mutations L858R/T790M was treated with varying concentrations of β-elemene and/or erlotinib. The effects of β-elemene on cell proliferation, migration, apoptosis, and the expression of relevant proteins of NCI-H1975 cells were evaluated. The results revealed that β‑elemene significantly inhibited the growth, colony formation capacity, wound healing ability of NCI-H1975 cells, and improved the sensitivity of NCI-H1975 cells to erlotinib. Compared with erlotinib alone, β-elemene plus erlotinib significantly promoted the apoptosis of NCI-H1975 c...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jue Wang, Cong Xu, Ying Chen, Le Shao, Ting Li, Xingxing Fan, Lili Yu, Ruonan Zhang, Bi Chen, Hongwei Chen, Xinbing Sui, Elaine Lai-Han Leung, Qibiao Wu Tags: Research Paper Source Type: research
Updates of Pathogenesis, Diagnostic and Therapeutic Perspectives for Ovarian Clear Cell Carcinoma
Ovarian clear cell carcinoma (OCCC) is a special pathological type of epithelial ovarian carcinoma (EOC) and has a high prevalence in Asia without specific molecular subtype classification. Endometriosis is a recognized precancerous lesion that carries 3-fold increased risk of OCCC. Ovarian endometrioid carcinoma, which also originates from endometriosis, shares several features with OCCC, including platinum resistance and younger age at diagnosis. Patients with OCCC have about a 2.5 to 4 times greater risk of having a venous thromboembolism (VTE) compared with other EOC, and OCCC tends to metastasize through lymphatic ves...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Chenchen Zhu, Zhihao Xu, Tianjiao Zhang, Lili Qian, Weihua Xiao, Haiming Wei, Tengchuan Jin, Ying Zhou Tags: Review Source Type: research
USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP
Chemotherapy plays an important role in the treatment of patients with colorectal cancer (CRC). However, the resistance to chemotherapy severely affects the prognosis of CRC patients and the mechanisms are still poorly understood. Our study investigated the role of ubiquitin-specific protease 11 (USP11) in CRC chemotherapy and found that USP11 could induce resistance to 5-fluorouracil by activating autophagy. A series of in vitro and in vivo experiments revealed that USP11 promoted autophagy through AMPK/Akt/mTOR pathway via stabilizing valosin-containing protein (VCP). Overall, our study demonstrated that USP11 might be v...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hongze Sun, Rangrang Wang, Yuan Liu, Haitao Mei, Xueni Liu, Zhihai Peng Tags: Research Paper Source Type: research
Secular trends in the incidence and survival of all leukemia types in the United States from 1975 to 2017
Conclusions: Based on SEER data, the leukemia incidence increased gradually over the past decades, and then began to decline in recent years in the United States. The 5-year relative survival rate increased incrementally over time, especially among young patients. However, the huge disparities among different sexes, races, histological subtypes, and age groups, emphasize that precise causes control and innovative treatments need to be developed to reduce the incidence and improve the prognosis, especially among specific populations. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xiaorong Yang, Hui Chen, Jinyu Man, Tongchao Zhang, Xiaolin Yin, Qiufeng He, Ming Lu Tags: Research Paper Source Type: research
LINC00184 involved in the regulatory network of ANGPT2 via ceRNA mediated miR-145 inhibition in gastric cancer
Conclusions: Our findings indicate that the LINC00184/miR-145/ANGPT2 pathway has a crucial function in the development of GC and can act as a possible biomarker and targets for GC therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hai-yan Piao, Shuai Guo, Haoyi Jin, Yue Wang, Jun Zhang Tags: Research Paper Source Type: research
Role of CT texture features for predicting outcome of pancreatic cancer patients with liver metastases
Conclusion: The RS derived from significant texture features of primary tumors and metastases shows promise as a prognostic biomarker of OS of patients with MPC. A nomogram based on the RS and other independent prognostic clinicopathological factors accurately predicts OS. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Junjie Hang, Kequn Xu, Ruohan Yin, Yueting Shao, Muhan Liu, Haifeng Shi, Xiaoyong Wang, Lixia Wu Tags: Research Paper Source Type: research
Classification of Clear Cell Renal Cell Carcinoma based on Tumor Suppressor Genomic Profiling
Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of malignancy in adults. However, the clinical significance of tumor suppressor genes (TSG) is largely elusive. Herein, the expression profile TSGs and its clinical response in ccRCC were investigated. A total of 603 ccRCC samples from two cohorts (TCGA and ICGC) were retrieved in this study. Three molecular subtypes (C1, C2, and C3) were identified based on the TSGs expression profile in the TCGA dataset. Through Weighted Gene Correlation Network Analysis (WGCNA), six modules associated with three subtypes were identified. Pathway enrichment for the module...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Weimin Zhong, Fengling Zhang, Chaoqun Huang, Yao Lin, Jiyi Huang Tags: Research Paper Source Type: research
Identification of a Prognostic Signature Model with Tumor Microenvironment for predicting Disease-free Survival after Radical Prostatectomy
Conclusions: Our study established and validated an 18-gene prognostic signature model associated with TME, which might serve as a prognosis stratification tool to predict DFS in PCa patients after radical prostatectomy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hao Zhao, Xuening Zhang, Zhan Shi, Bingxin Guo, Wenli Zhang, Kun He, Xueqi Hu, Songhe Shi Tags: Research Paper Source Type: research
Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer
Conclusions: At early stage, cardia cancer had a poor prognosis compared with non-cardia cancer. The prevention and treatment of early cardia cancer need to be seriously treated. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Liting Lv, Xiao Liang, Dan Wu, Feng Wang, Yan Zhang, Hui Cang, Xiongwei Deng, Mei Li Tags: Research Paper Source Type: research
Prognostic Value of the Glasgow Prognostic Score on Overall Survival in patients with Advanced Non-Small Cell Lung Cancer
Conclusion: High pretreatment GPS is independently associated with worse OS in patients with advanced NSCLC. GPS should be considered in patient counseling and decision-making and needs to be further validated by large-cohort and prospective studies. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Mingmei Pan, Yun Zhao, Jianbo He, Huanqiong Wu, Yujia Pan, Qitao Yu, Shaozhang Zhou Tags: Research Paper Source Type: research
MRPL42 is activated by YY1 to promote lung adenocarcinoma progression
Mammalian mitochondrial ribosomal proteins are a group of protein factors encoded by nuclear genes, responsible for the synthesis of proteins in mitochondria. As a member of mitochondrial ribosomal proteins, MRPL42 (mitochondrial ribosomal protein L42) belongs to 28S and 39S subunits. The current literature showed that its role in lung adenocarcinoma (LUAD) was not clear. We found that MRPL42 was highly expressed in early-stage LUAD tissues and cell lines, and remarkably related to the prognosis of patients. Knockdown of MRPL42 could reduce the proliferation and colonization, promote cell cycle arrest in G1/S phase, and we...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wei Jiang, Chengpeng Zhang, Yunteng Kang, Xiaojun Yu, Pei Pang, Guangbin Li, Yu Feng Tags: Research Paper Source Type: research
SCARA5 inhibits gastric cancer progression via epithelial-mesenchymal transition suppression
Scavenger receptor class A member 5 (SCARA5) has been reported to be implicated in several types of cancer. However, its biological roles and mechanism of SCARA5 in gastric cancer (GC) have not been elucidated. In the present study, SCARA5 expression was found to be downregulated in GC which was associated with promoter methylation. The protein level of SCARA5 was negatively associated with aggressive clinicopathological characteristics, as well as poor prognosis. Moreover, SCARA5 overexpression markedly suppressed the growth, migration and invasion of GC cell lines in vitro. Furthermore, upregulation of SCARA5 inhibited g...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hangyu Zhang, Changgang Liu, Xinbo Wang, Yongfang Wang, Jie Zheng Tags: Research Paper Source Type: research
Msi1 inhibits cervical cancer cell apoptosis by downregulating BAK through AKT signaling
In this study, we found that the expression of Msi1 inhibited cervical cancer cell apoptosis in vitro and in vivo. Furthermore, the expression of Msi1 downregulated the expression of PTEN, while AKT signaling was activated, which resulted in a reduction in the proapoptotic protein BAK. In addition, rescue the expression of BAK in Msi1 expressing cervical cancer cells induced the increase of apoptosis cells. These findings indicate that Msi1 regulates cervical cancer cell apoptosis by inhibiting PTEN and activating AKT signaling, which leads to the downregulation of BAK. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xian Liu, Yanru Zhang, PengSheng Zheng, Nan Cui Tags: Research Paper Source Type: research
CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p
In this study, we observed that circNT5E expression was augmented in Bca tissues compared with that in adjacent normal tissues, and its expression level was positively associated with larger tumor size and lower survival rate. Further experiments showed that suppression of circNT5E restrained the growth and metastasis of Bca cells in vitro. circNT5E was mainly distributed in the cytoplasm and it captured miR-502-5p to increase HOXC8 mRNA and protein expression. Moreover, decreased miR-502-5p obviously reversed the circNT5E silencing-mediated inhibition of Bca cell growth and migration. Thus, this study suggested that circN...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jinhui Yang, Xiaoyun Liu, Guangcheng Dai, Lanying Qu, Bo Tan, Bo Zhu, Fuming Qi, Xinyu Gai, Bo Cheng Tags: Research Paper Source Type: research
Identification of tumor mutation burden-related hub genes and the underlying mechanism in melanoma
Conclusions: We identified three TMB-associated key genes, established their ceRNA networks, and investigated their influence on therapeutic responses, which could provide insights into future precision medicine. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Chuan Zhang, Dan Dang, Chenlu Liu, Yuqian Wang, Xianling Cong Tags: Research Paper Source Type: research
