CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma
Cell division cycle associated 5 (CDCA5) is an important element for the interaction between cohesin and chromatin in interphase. It is abnormally expressed in many types of cancer and works as an indicator of poor prognosis, but little is known about its activity in hepatocellular carcinoma (HCC). In the present study, we found that the expression of CDCA5 was upregulated in HCC tissues compared to paracancerous tissues and had a negative correlation with patient survival. Cell proliferation and tumorigenesis were inhibited and cell apoptosis was induced with the knockdown of CDCA5, suggesting an oncogenic role of CDCA5 i...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hao Chen, Jun Chen, Long Zhao, Wenfeng Song, Zefeng Xuan, Jian Chen, Zequn Li, Guangyuan Song, Liangjie Hong, Penghong Song, Shusen Zheng Tags: Research Paper Source Type: research

BTF3 Silencing Inhibits the Proliferation of Osteosarcoma Cells
Osteosarcoma (OS) is one of the bone malignancy cancers with poor prognosis in the early stages worldwide. Basic transcription factor 3 (BTF3) is associated with the development of several types of cancer. The present study aimed to evaluate the role of BTF3 in OS. Silencing of BTF3 was achieved by using stable lentivirus transfection of siRNA targeting BTF3 in the human OS cell line Saos-2. Cell viability and colony-forming ability were measured using methyl-thaizolyl-tetrazolium (MTT) and colony formation assays, respectively. Propidium iodide staining and flow cytometry was used to detect the progression of the cell cyc...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Liu, Lin Jiang, Wanchun Wang, Tao Jiang Tags: Research Paper Source Type: research

Fine Mapping in Chromosome 3q28 Identified Two Variants Associated with Lung Cancer Risk in Asian Population
In conclusion, this is the first fine-mapping analysis of 3q28 region in Han Chinese, and we found two variants associated with lung cancer susceptibility in Asian population. What's more, rs3856776 was newly identified and might modulate lung cancer susceptibility by suppressing the function of LEPREL1. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yang Wen, Chen Zhu, Ni Li, Zhihua Li, Yang Cheng, Jing Dong, Meng Zhu, Yuzhuo Wang, Juncheng Dai, Hongxia Ma, Guangfu Jin, Min Dai, Zhibin Hu, Hongbing Shen Tags: Research Paper Source Type: research

AMPK Inhibition Suppresses the Malignant Phenotype of Pancreatic Cancer Cells in Part by Attenuating Aerobic Glycolysis
Pancreatic cancer is a highly aggressive tumor characterized by enhanced aerobic glycolysis. AMP-activated protein kinase (AMPK), which is identified as a well-known regulator of glycolysis, plays an essential role in tumorigenesis. In the present study, we aim to explore the function of AMPK in pancreatic cancer cells and attempt to clarify the possible underlying mechanism. The Cancer Genome Atlas (TCGA) data showed that elevated AMPK expression highly correlated with lower median survival time. In an in vitro study, inhibition of AMPK blocked the proliferation, migration, and invasion ability of four cell lines under no...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mingyue Hu, Xiangxu Chen, Li Ma, Yu Ma, Yuan Li, Huihui Song, Jiajia Xu, Lingna Zhou, Xiaoxue Li, Yuhui Jiang, Bo Kong, Peilin Huang Tags: Research Paper Source Type: research

The Fibroblast TIAM2 Promotes Lung Cancer Cell Invasion and Metastasis
Conclusion: Our results suggest that fibroblast TIAM2 promotes the invasion and migration of lung cancer cell, and OPG might be one of the main cytokines contributing to this pro-cancer process. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shuoke Li, Yangwei Ou, Shaobo Liu, Jiye Yin, Wei Zhuo, Masha Huang, Tao Zhu, Wei Zhang, Honghao Zhou, Zhaoqian Liu Tags: Research Paper Source Type: research

An Antibody Fab Fragment-based Chimeric Antigen Receptor Could Efficiently Eliminate Human Thyroid Cancer Cells
Thyroid cancer remains a significant health problem worldwide. Traditional chemotherapy does generate long-term benefit but are usually accompanied by severe side effects. Immunotherapy by adoptive infusion of T cells is now an attractive alternative to chemotherapy. Chimeric antigen receptor engineered lymphocytes have produced tremendous clinical outcomes in treating leukemia or lymphoma, but not in solid tumors, which is in part due to the low affinity of single chain Fv fragment or the rapid loss of transfused T cells. In present research, we designed a novel Fab based chimeric antigen receptor, which inherits the adva...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Honghong Duan, Huibin Huang, Guangjun Jing Tags: Research Paper Source Type: research

Up-regulated of Angiopoietin-Like Protein 4 Predicts Poor Prognosis in Cervical Cancer
Conclusion: Upregulated ANGPTL4 seems to be a useful marker for poor prognosis in cervical cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Dan Nie, Qianwen Zheng, Ling Liu, Xiguang Mao, Zhengyu Li Tags: Research Paper Source Type: research

Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China
Objectives: Understanding the prevalence and characteristics of high-risk human papillomavirus (hrHPV) with the large-scale multicenter data based on a US FDA-approved testing method is important to guide ongoing vaccination programs in China.Methods: We conducted a retrospective observational study based on data from 11 large hospitals in central and eastern China. From October 1st, 2012 to December 31st, 2016, a total of 480,034 cervical specimens were collected, and 414,540 eligible participants (14-80 years, mean age 39.9 years) were included and tested using Cervista High-Risk HPV Assay (Hologic Inc., Bedford, Mass, U...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yi Wang, Yifan Meng, Wending Li, Xiaofei Zhang, Zaixing Deng, Mengjun Hu, Pingrong Shen, Shengfeng Xu, Chenglin Fu, Wen Jiang, Bing Wu, Kezhen Li, Gang Chen, Juncheng Wei, Ling Xi, Junbo Hu, Xing Xie, Ding Ma, Xiaodong Cheng, Peng Wu Tags: Research Paper Source Type: research

A Retrospective Cohort Study of Nasopharyngeal Carcinoma Screening and Hepatocellular Carcinoma Screening in Zhongshang City
Background: Nasopharyngeal carcinoma (NPC) and hepatocellular carcinoma (HCC) have remained a major burden of public health in Southern China. The screening for early disease in asymptomatic individuals has potentially been the most promising tool to improve cancer treatment outcomes. The present study aims to evaluate the compliance rates and characteristics of cancer incidence in the population of NPC and HCC screening.Methods: Enzyme-linked immunsorbent assay (ELISA) for Epstein-Barr virus (EBV) antibodies and Hepatitis B surface antigen (HBsAg) was performed in this population. NPC high/medium risk and HCC high risk in...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xia Yu, Mingfang Ji, Weimin Cheng, Biaohua Wu, Shifeng Lian, Yun Du, Sumei Cao Tags: Research Paper Source Type: research

Cyclin-Dependent Kinase Inhibitor 3 Promoted Cell Proliferation by Driving Cell Cycle from G1 to S Phase in Esophageal Squamous Cell Carcinoma
Conclusions: Our study suggested that CDKN3 acted as an oncogene in human ESCC and may accelerate the G1/S transition by affecting CyclinD-CDK4 complex via regulating pAKT-p53-p21 axis and p27 independent of AKT. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Juan Liu, Li Min, Shengtao Zhu, Qingdong Guo, Hengcun Li, Zheng Zhang, Yu Zhao, Changqin Xu, Shutian Zhang Tags: Research Paper Source Type: research

Oxaliplatin-Based Regimen is Superior to Cisplatin-Based Regimen in Tumour Remission as First-line Chemotherapy for Advanced Gastric Cancer: A Meta-Analysis
Conclusions: Oxaliplatin-based regimen is superior to cisplatin-based regimen in tumour remission as first-line chemotherapy for advanced GC, and is associated with less toxicity and better tolerability. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fei Zhang, Yiyin Zhang, Zhenya Jia, Hongyang Wu, Kangsheng Gu Tags: Research Paper Source Type: research

Long Non-Coding RNA NONHSAT076754 Promotes Invasion and Metastasis in Epithelial Ovarian Cancer
Although accumulating evidence suggests that long non-coding RNAs (lncRNAs) are critical determinants of ovarian cancer development and progression, reports of metastasis-associated lncRNAs are limited. Here, we focused on NONHSAT076754 and explored its expression level, clinical value, biological behavior and molecular basis in epithelial ovarian cancer (EOC) metastasis. The results showed that NONHSAT076754 expression was increased in EOC tissues and cell lines and that this expression was closely related with FIGO stage, high tumor grade and lymph node metastasis. Furthermore, NONHSAT076754 knockdown markedly inhibited ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaojing Lin, Xiaoyan Tang, Tingting Zheng, Junjun Qiu, Keqin Hua Tags: Research Paper Source Type: research

Hsa-let-7e-5p Inhibits the Proliferation and Metastasis of Head and Neck Squamous Cell Carcinoma Cells by Targeting Chemokine Receptor 7
This study aimed at determining the role of hsa-let-7e-5p in the progression of head and neck squamous cell carcinoma (HNSCC). The relative levels of hsa-let-7e-5p transcripts in 15 paired of HNSCC and adjacent non-tumor tissues and cells were examined by quantitative real-time PCR (qRT-PCR). The potential targets of hsa-let-7e-5p were predicted and validated by luciferase assay. The impact of altered hsa-let-7e-5p expression on HNSCC cell proliferation and metastasis was determined by CCK-8, wound healing, transwell migration and invasion assays. The effect of hsa-let-7e-5p over-expression on the growth of HNSCC was exami...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Song Wang, Shan Jin, Min-Da Liu, Pai Pang, Hong Wu, Zhong-Zheng Qi, Fa-Yu Liu, Chang-Fu Sun Tags: Research Paper Source Type: research

AB0 Blood Group and Ovarian Cancer Survival
Conclusions: AB0 blood group might be a preoperative prognostic factor in epithelial ovarian cancer patients. According to the literature, postoperative residual disease remain the most important prognostic factor also in our study. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Vincenzo Dario Mandato, Federica Torricelli, Valentina Mastrofilippo, Gino Ciarlini, Debora Pirillo, Gianluca Annunziata, Bruno Casali, Martino Abrate, Giovanni Battista La Sala, Lorenzo Aguzzoli Tags: Research Paper Source Type: research

Serum exosomal miRNA-145 and miRNA-200c as promising biomarkers for preoperative diagnosis of ovarian carcinomas
Background: Exosomes are extracellular microvesicles that are released by most cells and widely distributed in various body fluids. Malignant cells secrete large amounts of exosomes containing various molecular constituents reflecting the originating tumor. We investigated the difference in microRNA (miRNA) expression in serum exosomes from the patients with benign, borderline and malignant ovarian masses to assess the diagnostic relevance of serum exosomal miRNAs as biomarkers for preoperative diagnosis of ovarian carcinoma.Methods: A total of 68 cases of ovarian masses were enrolled, comprising benign ovarian cysts (beni...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sewha Kim, Min Chul Choi, Ju-Yeon Jeong, Sohyun Hwang, Sang Geun Jung, Won Duk Joo, Hyun Park, Seung Hoon Song, Chan Lee, Tae Hoen Kim, Hee-Jung An Tags: Research Paper Source Type: research

Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma
This study included a total of 527 esophageal squamous cell carcinoma patients and 505 gender- and age- matched healthy controls from five hospitals in China. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression models.Results Subjects with sleep duration
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Pengxiang Chen, Cong Wang, Qingxu Song, Tong Chen, Jinxiu Jiang, Xiaoli Zhang, Jiaqi Xu, Jianfeng Cui, Yufeng Cheng Tags: Research Paper Source Type: research

Comparisons and Combined Application of Two-Dimensional and Three-Dimensional Real-time Shear Wave Elastography in Diagnosis of Thyroid Nodules
Conclusions 2D SWE or 3D SWE alone could not improve the diagnostic value of differentiating malignant from benign thyroid nodules comparing to conventional B-mode ultrasound. But combination methods could improve the diagnostic value, especially B-mode US + 2D SWE. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Rui-Jun Han, Jing Du, Feng-Hua Li, Hao-Ru Zong, Jia-Dong Wang, Yu-Ling Shen, Qin-Yi Zhou Tags: Research Paper Source Type: research

The Efficacy of Upfront Intracranial Radiation with TKI Compared to TKI Alone in the NSCLC Patients Harboring EGFR Mutation and Brain Metastases
Conclusion: Compared to upfront intracranial RT, the salvage RT to oligo-progressive disease allowed patients getting TKI to have similar time on initial TKI and OS despite worse iPFS. The best timing of intracranial RT remains to be further verified. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chunyu Wang, Xiaotong Lu, Zongmei Zhou, Jingbo Wang, Zhouguang Hui, Jun Liang, QinFu Feng, Dongfu Chen, Zefen Xiao, Jima Lv, Xiaozhen Wang, Xin Wang, Tao Zhang, Lei Deng, Wenqing Wang, Jianping Xiao, Junling Li, Nan Bi, Luhua Wang Tags: Research Paper Source Type: research

ERG Tumor Type is Less Frequent in High Grade and High Stage Prostate Cancers of Chinese Men
Conclusion: The intriguing association of even lower ERG frequencies with high Gleason scores and higher T-stages provides impetus for current driver gene discoveries focused on the predominantly ERG negative prostate cancers of Asian men. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jiang Baohong, Jason Sedarsky, Shiv Srivastava, Isabell Sesterhenn, Albert Dobi, Li Quanlin Tags: Research Paper Source Type: research

Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1 α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells
In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underlying molecular mechanisms. A549 and H460 NSCLC cells were treated with different concentrations of CyH for 24 h. The effects of CyH on NSCLC angiogenesis in vitro and in vivo were investigated. Hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression in xenografted NSCLC of nude mice was analyzed by immunohistochemistry. ELISA was used to analyze the concentration of VEGF in the conditioned media derived from treated and untreated NSCLC cells. Western blot was performed to detec...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yuefan Ma, Zihan Xiu, Zhiyuan Zhou, Bingyu Huang, Jiao Liu, Xiaofeng Wu, Sanzhong Li, Xudong Tang Tags: Research Paper Source Type: research

EZH2/Bcl-2 Coexpression Predicts Worse Survival in Diffuse Large B-cell Lymphomas and Demonstrates Poor Efficacy to Rituximab in Localized Lesions
Enhancer of zeste homolog 2 (EZH2) and Bcl-2 gene rearrangement or protein upregulation played pivotal roles in the carcinogenesis of various malignancies including lymphomas. However, EZH2/Bcl-2 expression pattern and its clinicopathologic/prognostic significance in diffuse large B-cell lymphoma (DLBCL) remain unclear. To identify the association among EZH2, Bcl-2, clinicopathologic parametres in DLBCL, 2 DLBCL patient sets (test cohort, n=85; validation cohort n=51) and DLBCL cell lines were studied by tumor tissue microarray (TMA), immunohistochemistry and western blot. The optimal cut-off of EZH2 was determined by X-ti...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yujie Deng, Xiaohui Chen, Chuanzhong Huang, Gang Chen, Fangfang Chen, Jianping Lu, Xi Shi, Cheng He, Zhiyong Zeng, Yanhua Qiu, Junqiang Chen, Rongbo Lin, Yanping Chen, Junmin Chen Tags: Research Paper Source Type: research

LncRNA HOTAIR up-regulation is strongly related with lymph nodes metastasis and LAR subtype of Triple Negative Breast Cancer
In this study we aimed to analyze the expression of the lncRNA HOTAIR, mainly involved in breast cancer disease, in a large case series of TNBC patients. We used ISH methods by a RNA probe to better define its staining in tumor tissues and its relation with clinical-pathological parameters and outcomes of patients.Our results show that high HOTAIR expression in tumor tissues is strongly correlated with lymph nodes metastasis (LNM) (p=0.039), as reported also for other tumor types, and has a direct strong association with Androgen Receptor (AR) expression (p= 0.019).These data confirm the prognostic role of HOTAIR in TNBC, ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Francesca Collina, Gabriella Aquino, Marianna Brogna, Sabrina Cipolletta, Gaetano Buonfanti, Michelino De Laurentiis, Maurizio Di Bonito, Monica Cantile, Gerardo Botti Tags: Research Paper Source Type: research

Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway
In this study, we characterized a novel lncRNA transcript, named UNC5B antisense RNA1 (UASR1). UASR1 is 647bp in length consisting of two exons. This lncRNA is an antisense of intron 1 of unc-5 netrin receptor B (UNC5B) gene. In breast cancer tissues, UASR1 was upregulated. Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. The migration of these cells also increased as demonstrated by wound healing and transwell assays. In contrast, silencing of UASR1 suppressed cell proliferation and migration. Further studies showed that UASR1 activated AKT and AKT-mediat...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhe Cao, Ping Wu, Min Su, Hongyan Ling, Ramina Khoshaba, Chenfei Huang, Han Gao, Yan Zhao, Jinjun Chen, Qianjin Liao, Deliang Cao, Junfei Jin, Xuewen Zhang Tags: Research Paper Source Type: research

Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells
Cancer cells are usually exposed to stressful environments, such as hypoxia, nutrient deprivation, and other metabolic dysfunctional regulation, leading to continuous endoplasmic reticulum (ER) stress. As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1α (IRE1α)-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression. Active XBP1 with transactivation domain functions as a transcription factor to regulate the expression of downstream target genes, including many oncogenic factors. The regulatory activity of...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Weimei Shi, Zhixi Chen, Linfu Li, Hai Liu, Rui Zhang, Qilai Cheng, Daohua Xu, Longhuo Wu Tags: Review Source Type: research

Preoperative anemia as a prognostic factor in patients with lung cancer: a systematic review and meta-analysis of epidemiological studies
In conclusion, pre-operative anemia was associated with poorer overall survival among LC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yang Liu, Yun-Peng Bai, Zi-Fang Zhou, Chang-Rui Jiang, Zhe Xu, Xiao-Xi Fan Tags: Research Paper Source Type: research

Low Preoperative Lymphocyte to Monocyte Ratio Serves as a Worse Prognostic Marker in Patients with Esophageal Squamous Cell Carcinoma Undergoing Curative Tumor Resection
This study aimed to investigate whether preoperative LMR could serve as a prognostic marker in patients with ESCC undergoing curative tumor resection. Medical records of 680 patients of ESCC after curative surgery without preoperative adjuvant therapy were obtained. The median of LMR was determined as the optimal cut off value. The association of LMR with clinical features of ESCC was analyzed using chi-square tests. Spearman's correlation coefficient was used to calculate the correlation. Disease-free survival (DFS) and overall survival (OS) stratified by LMR were evaluated using Kaplan-Meier method and log-rank test. The...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qian Song, Jun-zhou Wu, Sheng Wang Tags: Research Paper Source Type: research

Simultaneous Inhibition of EGFR and HER2 via Afatinib Augments the Radiosensitivity of Nasopharyngeal Carcinoma Cells
In this study, we observed that simultaneously inhibition of EGFR and HER2 by afatinib could augment the radiosensitivity of NPC cells; this approach has an advantage over erlotinib-mediated inhibition of EGFR alone. The afatinib-induced augmentation of NPC cell radiosensitivity was associated with increases in apoptosis and accumulation of DNA damage that were induced by radiation. In addition, the crosstalk between radiation-induced activities and EGFR-, and HER2-related downstream pathways may contribute to the enhancement of radiosensitivity. Our findings indicate the potential of repositioning afatinib or other ERBB-f...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fangling Huang, Xujun Liang, Xiaoli Min, Ye Zhang, Guoqiang Wang, Zhengrong Peng, Fang Peng, Maoyu Li, Lin Chen, Yongheng Chen Tags: Research Paper Source Type: research

Interleukin-35 as an Emerging Player in Tumor Microenvironment
IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate subunits has manifested suppressive actions on immune system, which is counterproductive in the context of cancers. Various reports have confirmed its inhibitory role on immune system which is carried out via formation of IL-35-producing regulatory T cells (iTr35), increased Treg development and suppressive Th17 cells growth. Although last decade has seen a great deal of scientific interest on this subject, the exact role, precise signal transduction and elaborative functions of IL-35 in tumor microenvironment (TME) remained elusive. S...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wenhua Xue, Dan Yan, Quancheng Kan Tags: Review Source Type: research

Cisplatin based induction chemotherapy modified by ERCC1 improved the outcome of young adults with locally advanced oral squamous cell carcinoma
Objective: To evaluate the efficacy of induction chemotherapy in young adults with locally advanced oral squamous cell carcinoma (OSCC) and the usefulness of ERCC1 as a prognostic indicator.Methods: A total of 156 young adults with locally advanced OSCC were retrospectively analyzed from May 2007 to May 2017. Cisplatin based induction chemotherapy followed by surgery and upfront surgery were the primary treatment options for locally advanced OSCC. ERCC1 was evaluated by immunohistochemistry. Multivariate analysis was performed to identify significant prognostic factors for the overall survival (OS) in young adults with loc...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yin Gong, Houyu Ju, Guoxin Ren, Yunteng Wu Tags: Research Paper Source Type: research

High Expression of PQBP1 and Low Expression of PCK2 are Associated with Metastasis and Recurrence of Osteosarcoma and Unfavorable Survival Outcomes of the Patients
In this study, we aimed to identify gene expression patterns associated with metastasis and recurrence in order to identify potential biomarkers with prognostic power. We found that high expression of polyglutamine tract-binding protein 1 (PQBP1) and low expression of phosphoenolpyruvate carboxykinase 2 (PCK2) were related to a high probability of recurrence and metastasis in OS patients and also predicted shorter recurrence-free survival (RFS) and metastasis-free survival (MFS) after adjustment for other clinical variables. Prediction models based on the combination of PQBP1 and PCK2 expression had good and robust predict...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yong Zhang, Haiyue Zhao, Wu Xu, Dinghua Jiang, Lixin Huang, Lisong Li Tags: Research Paper Source Type: research

Impact of Age on Risk of Lymph Node Positivity in Patients with Colon Cancer
Background: Lymph node (LN) positivity is a prognostic indicator in patients with colon cancer regardless of age, and age is an important parameter that impacts therapeutic recommendations. But little is known about the impact of age on LN positivity in patients with colon cancer.Methods: We analyzed 257,334 patients with colon cancer diagnosed from SEER database. Logistic regression was used to examine the association of age and LN positivity. Poisson regression was used to evaluate whether age was associated with the number of positive LNs.Results: LN positivity was inversely associated with age (P
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Haolu Wang, Hao Lu, Haotian Yang, Xianwen Zhang, Erik W. Thompson, Michael S. Roberts, Zhiqian Hu, Xiaowen Liang, Xinxing Li Tags: Research Paper Source Type: research

BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations regulating genome integrity, cell division and death. The integrity of cellular genome is closely controlled by the mechanisms of DNA damage signaling and DNA repair. The association of breast cancer susceptibility genes BRCA1 and BRCA2 with breast and ovarian cancer development was first demonstrated over 20 years ago. Since then the germline mutations within these genes were linked to genomic instability and increased risk of many other cancer types. Genomic instability is an engine of the oncogenic transformation of non-tumorigenic ce...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ielizaveta Gorodetska, Iryna Kozeretska, Anna Dubrovska Tags: Review Source Type: research

PSME3 Promotes TGFB1 Secretion by Pancreatic Cancer Cells to Induce Pancreatic Stellate Cell Proliferation
Pancreatic cancer is a highly malignant disease that is associated with poor prognosis. One hallmark of pancreatic cancer is excessive desmoplasia, characterized by fibrous or connective tissue growth and altered tumor stroma. Pancreatic stellate cells (PSCs) comprise a mesenchymal cell type that contributes to pancreas fibrosis and cancer progression. PSME3 is a regulatory subunit of the proteasome that is expressed in various cancers such as breast, ovarian, and pancreatic. Notably, PSME3 modulates lactate secretion in pancreatic cancer, suggesting a potential function in regulating pancreas fibrosis. However, the role o...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lianyuan Yu, Jun-Jie Li, Xiao-Long Liang, Huanwen Wu, Zhiyong Liang Tags: Research Paper Source Type: research

Efficacy and Safety of Nivolumab in Patients with Advanced Non-small-cell Lung Cancer and Poor Performance Status
Conclusion: Survival benefit of nivolumab in patients with NSCLC with poor PS, especially 3 or 4, was not confirmed. Further studies with larger numbers of patients are required to confirm our results. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hideyuki Katsura, Yukio Suga, Tomoyuki Araya, Toshiyuki Kita, Taro Yoneda, Nobuyoshi Tanaka, Ayumi Kawabata, Sotoki Ishita, Hiroki Mase Tags: Research Paper Source Type: research

Human Leukocyte Antigen (HLA) Class II -DRB1 and -DQB1 Alleles and the Association with Cervical Cancer in HIV/HPV Co-Infected Women in South Africa
Background: A subset of women who are co-infected with Human Immunodeficiency Virus type 1 (HIV) and Human papillomavirus (HPV), progress rapidly to invasive cervical cancer regardless of antiretroviral therapy (ART) or immune status. We posit that HIV/HPV co-infection along with specific host HLA II -DRB1 and -DQB1 alleles play a major role in cervical cancer development.Methodology: We conducted a hospital-based genetic susceptibility case-control study in Cape Town, South Africa. We recruited 256 women of the same race, from which a total of 624 HLA-DRB1 and -DQB1 class II genotypes were studied. We characterized HLA II...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ramadhani Chambuso, Raj Ramesar, Evelyn Kaambo, Lynette Denny, Jo-Ann Passmore, Anna-Lise Williamson, Clive M Gray Tags: Research Paper Source Type: research

Functional Polymorphisms in BARD1 Association with Neuroblastoma in a regional Han Chinese Population
Neuroblastoma (NB) is a sympathetic nervous system cancer for children, occupying approximately 15% of pediatric oncology deaths. BARD1, a tumor suppressor, is essential for genome stability by interaction with BRCA1. Here, we performed a systematic investigation for the association between SNPs in BARD1 and the risk of NB in Chinese population. After SNP screening in BARD1 gene, we performed case-control study of eleven selected SNPs in BARD1 with 339 NB patients and 778 cancer-free controls. The OR and 95% CI of these candidate SNPs were computed by logistic regression. After adjusted gender and age, seven out of eleven ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jin Shi, Yongbo Yu, Yaqiong Jin, Jie Lu, Jie Zhang, Huanmin Wang, Wei Han, Ping Chu, Jun Tai, Feng Chen, Huimin Ren, Yongli Guo, Xin Ni Tags: Research Paper Source Type: research

HLA Polymorphisms And TKI-Induced Liver Injury in Patients with Cancer: A Meta-analysis
Background: Tyrosine kinase inhibitors (TKIs) are widely used for patients with cancer, although liver injury has been observed in a small proportion of these patients. The aim of this study was to investigate the mechanisms underlying TKI-induced liver injury according to HLA polymorphisms.Methods: We systematically searched three electronic databases (PubMed, PMC, EmBase, and the Cochrane library) to identify studies that evaluated the impact of HLA polymorphisms on the incidence of TKI-induced liver injury in cancer patients as of November 2018. The summary odds ratios (ORs) with 95% confidence intervals (CIs) were calc...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qian Xiang, Zhuo Zhang, Yingchao Wu, Shuai Zuo, Qianxin Liu, Tao Liu, Xin Wang, Yimin Cui Tags: Research Paper Source Type: research

Surgery plus chemotherapy improves survival of patients with extremity soft tissue leiomyosarcoma and metastasis at presentation
Conclusion: Extremity soft tissue LMS patients who present with metastasis at diagnosis had a poor prognosis. Patients who performed surgery for primary tumors and chemotherapy had a better chance for prolonged survival. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sheng-Jun Qian, Jia-Qi Wu, Zhan Wang, Bo Zhang Tags: Research Paper Source Type: research

UBE2C overexpression in melanoma and its essential role in G2/M transition
In this study, we found a significant high expression level of UBE2C in melanoma by an in silico analysis of The Cancer Genome Atlas (TCGA) database, which was further validated using fresh melanoma samples. The KM plotter showed that UBE2C level was statistically related to the overall survival (OS) of melanoma patients (p
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guolong Liu, Jun Zhao, Boyu Pan, Gang Ma, Liren Liu Tags: Research Paper Source Type: research

Herpesvirus acts with the cytoskeleton and promotes cancer progression
This article aims to clarify the interaction between the virus and cytoskeleton components in the process of Herpesvirus infection and the molecular motor, cytoskeleton-associated proteins and drugs that play an important role in the process of a Herpesvirus infection and carcinogenesis process. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yingfen Wu, Fang Wei, Le Tang, Qianjin Liao, Hui Wang, Lei Shi, Zhaojian Gong, Wenling Zhang, Ming Zhou, Bo Xiang, Xu Wu, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng, Fang Xiong, Can Guo Tags: Review Source Type: research

Nifurtimox Inhibits the Progression of Neuroblastoma in vivo
Neuroblastoma was one of the most life-threatening cancer developed in children, yet the conventional therapies currently used leave an unmet gap for clinical requirements. Temozolomide is the first line of drug in the treatment of neuroblastorma nowadays. Giving the fact that temozolomide treatment offered limited healing effect and patients responded divergently, an alternative beneficial path is urgently requested. Nifurtimox, a drug against Trypanosoma cruzi, was happened to find competent in treating a patient who carried aggressive neuroblastoma. Although in vitro studies demonstrated that nifurtimox has cytotoxic fe...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Eryan Kong, Jiangli Zhu, Wentao Wu, Hongguang Ren, Xuemiao Jiao, Hui Wang, Zhongjian Zhang Tags: Research Paper Source Type: research

The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma
Conclusion: Knowledge of the expression levels of the PSME gene family could provide a sensitive strategy for predicting prognosis in SKCM. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qiaoqi Wang, Fuqiang Pan, Sizhu Li, Rui Huang, Xiangkun Wang, Shijun Wang, Xiwen Liao, Dong Li, Liming Zhang Tags: Research Paper Source Type: research

Tropomyosin-1 Functions as a Tumor Suppressor with Respect to Cell Proliferation, Angiogenesis and Metastasis in Renal Cell Carcinoma
Conclusions: TPM1 functions as a tumor suppressor with respect to cell proliferation, angiogenesis and metastasis in RCC, suggesting that it is a potential therapeutic target for advanced RCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jin Wang, Chao Tang, Chao Yang, Qi Zheng, Yuchuan Hou Tags: Research Paper Source Type: research

Clinical significance of serum markers reflecting gastric function and H. pylori infection in colorectal cancer
Purpose: The study was conducted to investigate the relationship of serum pepsinogens PGI, PGII, gastrin-17, and Hp-IgG with colorectal cancer (CRC), aiming to explore the clinical significance of serum markers reflecting gastric function and H. pylori infection in CRC.Methods: A total of 569 CRC cases and 569 age and sex-matched controls were enrolled in this study between June 2012 and April 2016 from The First Hospital of China Medical University. The serum markers reflecting gastric function and H. pylori infection were detected using ELISA, including PGI, PGII, PGI/II ratio, G-17 and Hp-IgG. Information of clinicopath...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qing-yue Zhang, Zhi Lv, Li-ping Sun, Nan-nan Dong, Cheng-zhong Xing, Yuan Yuan Tags: Research Paper Source Type: research

Prostate specific antigen (PSA) persistence 6 weeks after radical prostatectomy and pelvic lymph node dissection as predictive factor of radiographic progression in node-positive prostate cancer patients
Conclusions: Early assessment of PSA after surgery is important for predicting radiographic progression in node-positive prostate cancer patients. Risk stratification based on the early PSA value after surgery would be helpful to identify patients who may benefit from early adjuvant therapies. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jung Kwon Kim, Chang Wook Jeong, Ja Hyeon Ku, Hyun Hoe Kim, Cheol Kwak Tags: Research Paper Source Type: research

Perineural and lymphovascular invasion predicts for poor prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and surgery
Background: Perineural invasion (PNI) and lymphovascular invasion (LVI) are associated with poor prognosis in colorectal cancer, but their clinical significance is still controversial for patients with locally advanced rectal cancer (LARC) who had received neoadjuvant chemoradiotherapy (nCRT) and surgical resection. The aim of this study was to confirm the correlation between PNI and/or LVI and clinical prognosis and to further confirm whether PNI and/or LVI can be used as potential prognostic indicators of adjuvant chemotherapy after nCRT and surgery in LARC.Methods: From February 2002 to December 2012, a total of 181 pat...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Quanquan Sun, Tongxin Liu, Peng Liu, Jialin Luo, Na Zhang, Ke Lu, Haixing Ju, Yuping Zhu, Wei Wu, Lingnan Zhang, Yongtian Fan, Yong Liu, Dechuan Li, Yuan Zhu, Luying Liu Tags: Research Paper Source Type: research

Identification of novel methylated DNA marker ZNF569 for head and neck squamous cell carcinoma
In conclusion, we have identified many novel differentially methylated genes that might be important for the lymph node metastasis of HNSCC. In addition, ZNF569 might play a tumor suppressive role in carcinogenesis of HNSCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiangzhen Liu, Xinyuan Zhao, Chenyu Gou Tags: Research Paper Source Type: research

Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway
Conclusion: SNORA71A functions as an oncogene in NSCLC and may serve as a therapeutic target and promising prognostic biomarker of NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guiliang Tang, Zihang Zeng, Wenjie Sun, Shuying Li, Chengcheng You, Fang Tang, Shan Peng, Shijing Ma, Yuan Luo, Jieyu Xu, Xiaoli Tian, Nannan Zhang, Yan Gong, Conghua Xie Tags: Research Paper Source Type: research

MUS81 Inhibition Increases the Sensitivity to Therapy Effect in Epithelial Ovarian Cancer via Regulating CyclinB Pathway
In this study, MUS81-downregulated cells were generated using lentivirus-mediated RNAi. Our results demonstrated that the inhibition of MUS81 expression activated the CHK1 and CyclinB signaling pathways and sensitized ovarian cancer cells to X-ray and Olaparib treatment both in vitro and in vivo. MUS81 may be a potential therapeutic target for epithelial ovarian cancer (EOC). (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ailing Zhong, Hui Zheng, Hongqin Zhang, Jiajun Sun, Jiabin Shen, Minjie Deng, Miaomiao Chen, Renquan Lu, Lin Guo Tags: Research Paper Source Type: research

Association between Sedative-hypnotics and Subsequent Cancer in Patients with and without Insomnia: A 14-year Follow-up Study in Taiwan
Conclusions: The use of sedative-hypnotics in patients either with or without insomnia was associated with subsequent cancer development in the Taiwanese population. Increased risks of oral, liver, and breast cancer were found in the patients with the use of sedative-hypnotics. The use of sedative-hypnotics should be discouraged for treating patients with or without insomnia in Taiwan. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hui-Fen Fang, Tzu-Yin Lee, King Cheung Hui, Howard Chi Ho Yim, Mei-Ju Chi, Min-Huey Chung Tags: Research Paper Source Type: research