Anti-fibrotic properties of an adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma
This study was designed to unravel the potential roles of C1q/TNF-related protein 6 (CTRP6) in the fibrotic cancer microenvironment of diffuse-type gastric adenocarcinoma. A total of 49 diffuse-type gastric cancer samples were evaluated in this study, and 23 of these samples exhibited focal CTRP6 immunoreactivity. CTRP6 immunoreactivity was found to be correlated with favorable survival outcomes, in terms of both overall and relapse-free survival rates, but this trend did not reach significance (P = 0.15). By contrast, CTRP6 immunoreactivity was significantly correlated with relapse-free survival rates in patients with dif...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yoshinori Iwata, Itaru Yasufuku, Chiemi Saigo, Yusuke Kito, Tamotsu Takeuchi, Kazuhiro Yoshida Tags: Research Paper Source Type: research
Cytochalasin H isolated from mangrove-derived endophytic fungus inhibits epithelial-mesenchymal transition and cancer stemness via YAP/TAZ signaling pathway in non-small cell lung cancer cells
In this study, we further investigated the effect of CyH on epithelial-mesenchymal transition (EMT) and cancer stemness of A549 and NCI-H460 NSCLC cells and the underlying mechanisms, especially the role of YAP/ TAZ signaling pathway in the process. Our results showed that CyH significantly inhibited invasive ability and the sphere formation of NSCLC cells. The expression of E-cadherin, an EMT epithelial marker, was obviously up-regulated, while the expression of Vimentin and N-cadherin, the EMT mesenchymal markers, was dramatically down-regulated by CyH treatment in NSCLC cells. Moreover, the expression of EMT-associated ...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Zihan Xiu, Jiao Liu, Xin Wu, Xiangyong Li, Sanzhong Li, Xiaofeng Wu, Xiaohua Lv, Hua Ye, Xudong Tang Tags: Research Paper Source Type: research
Decision-making of adjuvant therapy in pT1N1M0 gastric cancer: Should radiotherapy be added to chemotherapy? A propensity score-matched analysis
Conclusion: The survival benefit of ACRT and ACT for pT1N1M0 GC patients following gastrectomy was confirmed in the SEER cohort. RT added to ACT might be recommended according to Lauren's classification and tumor grade in clinical decision making. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Siwei Pan, Songcheng Yin, Zhi Zhu, Funan Liu, Huimian Xu Tags: Research Paper Source Type: research
Research progress in the role and mechanism of Cadherin-11 in different diseases
Cadherin is an important cell-cell adhesion molecule, which mediates intercellular adhesion through calcium dependent affinity interaction. Cadherin-11 (CDH11, OB-cadherin) is a member of cadherin family, and its gene is situated on chromosome 16q22.1. Increasing lines of researches have proved that CDH11 plays important roles in the occurrence and development of a lot of diseases, such as tumors, arthritis and so on. CDH11 often leads to promoter methylation inactivation, which can induce cancer cell apoptosis, suppress cell motility and invasion, and can inhibit cancer through Wnt/β-catenin, AKT/Rho A and NF-κB...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xinyi Chen, Hongjiao Xiang, Shiyu Yu, Yifei Lu, Tao Wu Tags: Review Source Type: research
LncRNA FAM83A-AS1 promotes ESCC progression by regulating miR-214/CDC25B axis
Conclusions: Collectively, we concluded that FAM83A-AS1 facilitated ESCC progression by regulating the miR-214/CDC25B axis. Our study showed FAM83A-AS1 may act as a promising target for ESCC diagnosis and therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jinlin Jia, Hongle Li, Jie Chu, Jinxiu Sheng, Chang Wang, Zimo Jia, Weiwei Meng, Huiqing Yin, Junhu Wan, Fucheng He Tags: Research Paper Source Type: research
