Translation of gastric disease progression at gene level expression
In this study, we performed a genome-wide gene-expression analysis in gastric biopsies of patients chronically infected with H. pylori, using the potential of high-throughput technologies that have not been fully exploited in this area. Here we illustrate the potential correlation of H. pylori infection with the gene expression changes in follicular gastritis, chronic gastritis and intestinal metaplasia. We also suggest its potential as biomarkers of each condition. An exploratory set of 21 biopsies from patients with follicular gastritis, chronic gastritis, and intestinal metaplasia were analyzed by gene-expression microa...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Stephanie Euridice Morales-Guerrero, Claudia Ivette Rivas-Ortiz, Sergio Ponce de Le ó n-Rosales, Armando Gamboa-Dom í nguez, Claudia Rangel-Escare ñ o, Luis Federico Uscanga-Dom í nguez, Germ á n Rub é n Aguilar-Guti é rrez, David Kershenobich-Stal Tags: Research Paper Source Type: research
Inhibition of Carbonyl Reductase 1 Enhances Metastasis of Head and Neck Squamous Cell Carcinoma through β -catenin-Mediated Epithelial-Mesenchymal Transition
Conclusion: Our findings suggested that CBR1 plays an important role in metastasis of HNSCC tumors via regulation of ROS-mediated β-catenin activity, and that CBR1 may be marker for progression of HNSCC to metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Miyong Yun, Ae Jin Choi, Seon Rang Woo, Joo Kyung Noh, Ji-Youn Sung, Jung-Woo Lee, Young-Gyu Eun Tags: Research Paper Source Type: research
In silico analysis of the prognostic value of FAS mRNA in malignancies
Conclusions: In summary, the dominant function of FAS may vary in different malignancies. FAS mRNA expression was correlated with better OS in breast cancer, gastric cancer and lung cancer, but worse OS in pancreatic cancer and AML. We also suggested that FAS mRNA expression could be a potential biomarker for cabozantinib and erlotinib. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhigang Chen, Jun Wu, Hailin Xu, Xiuyan Yu, Ke Wang Tags: Research Paper Source Type: research
Cell Block as a Surrogate for Programmed Death-Ligand 1 Staining Testing in Patients of Non-Small Cell Lung Cancer
Conclusion: Cytological cell block specimens may serve as a surrogate for PD-L1 staining in patients of NSCLC when more than 400-500 cancer cells were contained (over 400 cancer cells for 28-8, over 500 cancer cells for SP142). (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhengwei Dong, Yiwei Liu, Tao Jiang, Likun Hou, Fengying Wu, Guanghui Gao, Xuefei Li, Chao Zhao, Yan Wang, Shuo Yang, Shiqi Mao, Qian Liu, Yumei Li, Chuan Xu, Chunyan Wu, Shengxiang Ren, Caicun Zhou, Jun Zhang, Fred R. Hirsch Tags: Research Paper Source Type: research
Nedaplatin reduces multidrug resistance of non-small cell lung cancer by downregulating the expression of long non-coding RNA MVIH
In conclusion, LncRNA MVIH is upregulated in drug resistant NSCLC cells. Nedaplatin can reduce the expression of MVIH and reverse EMT process, thus reversing the drug resistance of cisplatin in non-small cell lung cancer cells. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Changwen Jing, Zhuo Wang, Rui Lou, Jianzhong Wu, Chen Shi, Dan Chen, Rong Ma, Siwen Liu, Haixia Cao, Jifeng Feng Tags: Research Paper Source Type: research
Hyperactivation of IL-6/STAT3 pathway leaded to the poor prognosis of post-TACE HCCs by HIF-1 α /SNAI1 axis-induced epithelial to mesenchymal transition
Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with higher HIF-1α suffered from unfavorable OS after TACE. mRNA expression microarray revealed that HIF-1α was potential target of p-STAT3 which was verified by ChIP and immunoblotting assay. Activation of IL-6/STAT3/HIF-1α signaling was found to promote EMT and chemoresistance to Doxorubicin in vitro...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaohong Gai, Peng Zhou, Meng Xu, Zhikui Liu, Xin Zheng, Qingguang Liu Tags: Research Paper Source Type: research
Diabetes and its Potential Impact on Head and Neck Oncogenesis
In recent years, the incidence of diabetes mellitus and cancer has increased sharply; indeed, these have become the two most important diseases threatening health and survival. Head and neck (HN) tumors are the sixth most common malignancies in humans. Numerous studies have shown that there are many common risk factors for diabetes mellitus and HN squamous cell carcinoma, including advanced age, poor diet and lifestyle, and environmental factors. However, the mechanism linking the two diseases has not been identified. A number of studies have shown that diabetes affects the development, metastasis, and prognosis of HN canc...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaofeng Wang, Huiyu Wang, Tianfu Zhang, Lu Cai, Enyong Dai, Jinting He Tags: Review Source Type: research
The Polymorphisms of lncRNA HOXA11-AS and the risk of Lung Cancer in Northeastern Chinese population
This study aimed to evaluate the effect of HOXA11-AS polymorphisms (rs17427875 and rs11564004) on lung cancer susceptibility and its interaction with smoking exposure. This hospital-based case-control study, which included 466 cases and 557 controls, was carried out in Shenyang City, Liaoning province. The genotyping method was TaqMan allelic discrimination assay and all statistical analysis were performed by SPSS 20.0 and R (3.5.3). The results demonstrated that HOXA11AS-rs17427875 polymorphisms were correlated with the susceptibility of lung adenocarcinoma. T alleles of rs17427875 played a portal role in increasing lung ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Min Gao, Hang Li, Yanhong Bi, Ziwei Zhang, Shengli Wang, Juan Li, Zitai Yang, Xiaoting Lv, Baosen Zhou, Zhihua Yin Tags: Research Paper Source Type: research
CircRNA_100395 inhibits cell proliferation and metastasis in ovarian cancer via regulating miR-1228/p53/epithelial-mesenchymal transition (EMT) axis
Conclusion: CircRNA_100395 could inhibit cell growth and metastasis of ovarian cancer cells via regulating the miR-1228/p53/EMT axis. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xian Li, Shuihua Lin, Zhifeng Mo, Jinxing Jiang, Haifeng Tang, Cailin Wu, Jian Song Tags: Research Paper Source Type: research
JNK/AP1 Pathway Regulates MYC Expression and BCR Signaling through Ig Enhancers in Burkitt Lymphoma Cells
In Burkitt lymphoma (BL), a chromosomal translocation by which the MYC gene is fused to an immunoglobulin (Ig) gene locus is frequently found. The translocated MYC gene is overexpressed, which is the major driver of BL tumorigenesis. Studies have shown that Ig enhancers are essential for MYC overexpression, but the involved mechanisms are not fully understood. In addition, the survival of BL cells relies on B-cell receptor (BCR) signaling, which is determined by the levels of Ig molecules expressed on the cell surface. However, whether MYC has any impact on Ig expression and its functional relevance in BL has not been inve...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaoling Ding, Xiaoying Wang, Xueting Zhu, Jie Zhang, Yiqing Zhu, Xiaoyi Shao, Xiaorong Zhou Tags: Research Paper Source Type: research
Clinical prognostic implications of EPB41L4A expression in multiple myeloma
Background: Multiple myeloma (MM) is one of the most common incurable malignancies in malignant plasma cell disease. EPB41L4A is a target gene for the Wnt/β-catenin pathway, which is closely related to the survival of multiple myeloma cells. However, there is currently no research report on the prognostic significance of the EPB41L4A gene in MM.Methods: We studied the biological significance and prognostic significance of EPB41L4A expression in MM by integrating 1956 MM samples from 7 datasets, and explored the relationship between EPB41L4A expression and MM ISS stage, molecular type, therapeutic response and survival...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Weilong Zhang, Rui Lai, Xue He, Xiaoni Liu, Ye Zhang, Zuozhen Yang, Ping Yang, Jing Wang, Kai Hu, Xiaoliang Yuan, Xiuru Zhang, Weiyou Liu, Hongmei Jing Tags: Research Paper Source Type: research
Serum exosomal miR-122 as a potential diagnostic and prognostic biomarker of colorectal cancer with liver metastasis
Conclusions: Serum exosomal miR-122 was a novel potential diagnostic and prognostic biomarker in CRC patients with LM. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Li Sun, Xiangxiang Liu, Bei Pan, Xiuxiu Hu, Yefei Zhu, Yingying Su, Zhirui Guo, Guoying Zhang, Mu Xu, Xueni Xu, Huiling Sun, Shukui Wang Tags: Research Paper Source Type: research
Identifying Predictive Factors of Recurrence after Radical Resection in Gastric Cancer by RNA Immune-oncology Panel
Aiming to identify novel immunotargets for gastric cancer (GC), we retrospectively analyzed the formalin-fixed paraffin embedded (FFPE) samples of gastric cancer tissues from postoperative patients who relapsed or metastasized within (early recurrence, n=25) or after two years (late recurrence, n=23). RNA immune-oncology panel (RIOP) including 398 immune-related genes was used to detect the RNA expression level. Disease free survival (DFS) time in early and late recurrent group was 7.52±0.72 and 28.49±0.81 months, respectively. 18 genes were significantly different between the early and late recurrent groups,...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yuehong Cui, Shan Yu, Mengxuan Zhu, Xi Cheng, Yiyi Yu, Zhaoqing Tang, Xuefei Wang, Jun Hou, Yingyong Hou, Dandan Ren, Beibei Mao, Rashid Khalid, Tianshu Liu Tags: Research Paper Source Type: research
Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer
Programmed death receptor-1 (PD-1) and T cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) play important roles in tumor immune evasion. PD-1 blockade could produce an effective antitumor effect in many solid tumors except prostate cancer (PCa) because of rare programmed death ligand-1 (PD-L1) expression on PCa cells. Streptavidin (SA)-GM-CSF surface-anchored tumor cell (Anchored GM-CSF) vaccines could increase the number of tumor-infiltrating lymphocytes (TILs) and induce specific antitumor immune responses. The Anchored-GM-CSF vaccine and anti-PD-1 antibodies exerted synergistic effects in mouse models of...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xinji Zhang, Haixiong Chen, Guanfeng Li, Xiangyun Zhou, Yuqiang Shi, Feng Zou, Yuanxiang Chen, Jimin Gao, Shaomin Yang, Shihao Wu, Zhaolin Long Tags: Research Paper Source Type: research
Bazedoxifene enhances paclitaxel efficacy to suppress glioblastoma via altering Hippo/YAP pathway
In this study, we first identified that bazedoxifene bore the ability to reduce cell survival and cell invasion of glioblastoma cells. Furthermore, our results also revealed that bazedoxifene combining with paclitaxel had better efficacy to suppress glioblastoma progression by promoting apoptosis and reducing EMT. Combination of bazedoxifene and paclitaxel also accelerated YAP phosphorylation and inactivation. Importantly, preclinical animal model also verified our in vitro findings. Together, our data not only define the underlying mechanism responsible for action of bazedoxifene on glioblastoma cells but also build stron...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Weiwei Fu, Peng Zhao, Hong Li, Haiyang Fu, Xuejun Liu, Yingchao Liu, Jie Wu, Weiwei Fu Tags: Research Paper Source Type: research
Hypothesis: Retinoblastoma protein inactivation mediates effects of histone deacetylase inhibitor-induced Wnt hyperactivation in colorectal cancer cells
Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mechanisms by which Wnt hyperactivation promotes apoptosis are unknown. Inactivation of the retinoblastoma tumor suppressor occurs in some cancers and can lead to context-dependent cell proliferation or cell death/apoptosis. The function of retinoblastoma protein (Rb) in normal cells is modulation of cell cycle; in...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Michael Bordonaro Tags: Research Paper Source Type: research
Young age increases risk for lymph node positivity in gastric cancer: A Chinese multi-institutional database and US SEER database study
Conclusion: In the two large datasets, young age at diagnosis is associated with an increased risk of LN+. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yuming Jiang, Weicai Huang, Jingjing Xie, Zhen Han, Chuanli Chen, Sujuan Xi, Zepang Sun, Yanfeng Hu, Liying Zhao, Jiang Yu, Tuanjie Li, Zhiwei Zhou, Shirong Cai, Guoxin Li Tags: Research Paper Source Type: research
Efficacy of EGFR-TKIs with or without angiogenesis inhibitors in advanced non-small-cell lung cancer: A systematic review and meta-analysis
In the present study, we evaluated the efficacy and safety of epidermal growth factor receptor tyrosine kinases (EGFR-TKIs) combined with or without angiogenesis inhibitors in advanced non-small-cell lung cancer (NSCLC). We searched published randomized controlled trials (RCTs) comparing EGFR-TKIs with and without angiogenesis inhibitors for the treatment of advanced NSCLC. PubMed, EMBASE, PMC, the American Society of Clinical Oncology (ASCO) and the European Society of Medical Oncology (ESMO) databases were searched. The extracted data on progression-free survival (PFS) and overall survival (OS) were measured in terms of ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhaoxin Chen, Jia Wei, Xiaoting Ma, Jing Yu Tags: Research Paper Source Type: research
Emerging role of glucocorticoid receptor in castration resistant prostate cancer: A potential therapeutic target
Glucocorticoids are used as co-medication with chemotherapy for solid tumors to reduce inflammation as well as cytotoxic side effects and are effective in easing symptoms related to chemotherapy. However, emerging evidence suggests that glucocorticoids may contribute to failure of chemotherapy and tumor progression of castration resistant prostate cancer (CRPC). Thus, in recent years, glucocorticoid signaling pathway has become an important therapeutic target for CRPC. Understanding the exact mechanism of GR actions in CRPC is still work in progress. There are studies suggesting that GR expression can be upregulated follow...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Raj Kumar Tags: Review Source Type: research
Development of flow cytometry assays for measuring cell-membrane enzyme activity on individual cells
Conclusions: We report on two novel assays for measuring cell-membrane anchored enzyme activity on individual cells, and their potential use to directly study specific biology of cell-surface-expressing proteases. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Michael Gorry, Toshie Yoneyama, Lazar Vujanovic, Marcia L. Moss, Michelle A. Garlin, Miles A Miller, James Herman, Laura P. Stabile, Nikola L. Vujanovic Tags: Research Paper Source Type: research
Combining Bioinformatics and Experiments to Identify and Verify Key Genes with Prognostic Values in Endometrial Carcinoma
Endometrial carcinoma(EC) is the most common cancer of female reproductive system, thus requiring for new effective biomarkers which could predict the onset of EC and poor prognosis. Our study integrated two GEO datasets(i.e.GSE63678, GSE17025) and TCGA(The Cancer Genome Atlas ) UCEC data to screen out 344 common differentially expressed genes(DEGs), which were further analyzed by GO(gene ontology) functions and KEGG(Kyoto Encyclopedia of Gene and Genome) pathways. KEGG analysis results showed these DEGs were mainly enriched in cell cycle, oocyte meiosis, cellular senescence, carbon metabolism and p53 signaling pathway. To...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wenchao Zhang, Lingling Gao, Caixia Wang, Shuang Wang, Di Sun, Xiao Li, Miao Liu, Yue Qi, Juanjuan Liu, Bei Lin Tags: Research Paper Source Type: research
The Nucleolin Antagonist N6L Inhibits LINE1 Retrotransposon Activity in Non-Small Cell Lung Carcinoma Cells
Lung cancer is the most common cause of cancer death in the United States. The genome of non-small cell lung cancer (NSCLC), the most frequent lung cancer type, is strongly affected by Long Interspersed Nuclear Element (LINE1) insertions. Active LINE1s are repetitive DNA sequences that can amplify themselves in the genome utilizing a retrotransposition mechanism whereby LINE1 is copied via reverse transcription and inserted at target sites. ORF1p and ORF2p are LINE1 encoded proteins essential for LINE1 retrotransposition. LINE1s are silenced epigenetically in somatic tissues, and their reactivation has been associated with...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Kenneth S. Ramos, Sara Moore, Isabel Runge, Marco A. Tavera-Garcia, Ilaria Cascone, Jose Courty, Elsa M. Reyes-Reyes Tags: Research Paper Source Type: research
Anti-PD-1 Therapy plus Chemotherapy and/or Bevacizumab as Second Line or later Treatment for Patients with Advanced Non-Small Cell Lung Cancer
Immune checkpoint inhibitor combination therapy exhibited outstanding efficacy in first line setting for advanced non-small cell lung cancer (aNSCLC) patients. However, whether PD-1 inhibitor combined treatment is effective in second line or later setting remains unknown. Therefore, we retrospectively evaluated the efficacy of combined therapy of PD-1 inhibitor with chemotherapy and/or bevacizumab compared to PD-1 inhibitor alone for aNSCLC patients in second line or later setting. Patients with aNSCLC who have received anti-PD-1 based therapy between 2015 and 2017 were screened, and 55 patients were ultimately included an...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fan Zhang, Di Huang, Tao Li, Sujie Zhang, Jinliang Wang, Yuzi Zhang, Guoqiang Wang, Zhengyi Zhao, Junxun Ma, Lijie Wang, Danyang Sun, Pengfei Cui, Shangli Cai, Shunchang Jiao, Lei Zhao, Yi Hu Tags: Research Paper Source Type: research
Death Domain-Associated Protein Promotes Colon Cancer Metastasis through Direct Interaction with ZEB1
Conclusion: In sum, these findings supported that the loss of DAXX is associated with cancer cell metastases in CRC. ZEB1-mediated transcriptional suppression of E-cadherin is a possible mechanism. DAXX/ZEB-1 pathway could be a potential therapeutic target for preventing cancer metastasis in CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yanliang Liu, Fengqin Guo, Xu Zhu, Wenyi Guo, Tao Fu, Weixing Wang Tags: Research Paper Source Type: research
MicroRNA-144-3p Inhibits Tumorigenesis of Oral Squamous Cell Carcinoma by downregulating ERO1L
An increasing number of studies indicate that miR-144-3p is dysregulated in numerous cancers, but its role in oral squamous cell carcinoma (OSCC) remains largely unknown. Herein we demonstrated that miR-144-3p expression was significantly downregulated in OSCC tissues and cell lines. Moreover, the low level of miR-144-3p expression was associated with the clinical characteristics of OSCC patients. Furthermore, ectopic expression of miR-144-3p inhibited the proliferation, migration, and invasion of OSCC cells in vitro, and blunted the tumorigenic ability of OSCC cells in vivo. Additionally, the levels of miR-144-3p were neg...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xian Li, Yong Li, Chao Jiang, Liang Chen, Ning Gan Tags: Research Paper Source Type: research
The Effect of the Tumor Microenvironment and Tumor-Derived Metabolites on Dendritic Cell Function
Dendritic cells (DCs) have a critical effect on the outcome of adaptive immune responses against growing tumors. Recent studies on the metabolism on DCs provide new insights on the functioning of these critical controllers of innate and adaptive immunity. DCs within the tumor microenvironment (TME) often exist in an inactive state, which is thought to limit the adaptive immune response elicited by the growing tumor. Tumor-derived factors in the TME are known to suppress DC activation and result in functional alterations in DC phenotype. We are now beginning to appreciate that many of these factors can also induce changes i...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, Jie-Young Song, Han Geuk Seo, Hyun Soo Lee, Dae-Seog Lim Tags: Review Source Type: research
Pan-cancer analysis of ARID1A Alterations as Biomarkers for Immunotherapy Outcomes
ARID1A alterations would compromise mismatch repair pathway and increase the number of tumor-infiltrating lymphocytes and PD-L1 expression in some cancers, which would cooperate with immune checkpoint inhibitors (ICIs) treatment. However, a comprehensive analysis of ARID1A alteration frequency and its predictive value for ICI treatment outcome in cancers has not yet been investigated. Hence, we performed this pan-cancer analysis to evaluate the prevalence and predictive value of ARID1A alterations across>40,000 cases in multiple cancer types. We found a high frequency (6.2%) of ARID1A, which were associated with signifi...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Tao Jiang, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou Tags: Research Paper Source Type: research
A Panel of Urinary Long Non-coding RNAs Differentiate Bladder Cancer from Urocystitis
The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biomarkers to non-invasively differentiate bladder cancer from chronic urocystitis. To this end, we collected urine samples from both bladder cancer patients and urocystitis patients. These samples were divided into discovery group and validation group. In the discovery group, the expression levels of 16 cell-free urinary lncRNAs were measured by qPCR to discover candidate biomarkers. The diagnostic performance of the candidate lncRNA biomarkers was then evaluated, which led to a panel of lncRNA biomarkers for bladder cancer ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiao Yu, Ruiwei Wang, Chenglin Han, Zilong Wang, Xunbo Jin Tags: Research Paper Source Type: research
FOXM1 functions collaboratively with PLAU to promote gastric cancer progression
Conclusion: FOXM1+PLAU+ can serve as effective prognostic biomarkers and potential therapeutic targets for GC. Due to the additive effect of these two genes, screening for drugs or chemicals that targeting the expression patterns PLAU+FOXM1+ subgroup may exert important clinical impact on GC management. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Chao Ai, Jixin Zhang, Shenyi Lian, Jie Ma, Bal á zs Gy ő rffy, Zhenyuan Qian, Yong Han, Qin Feng Tags: Research Paper Source Type: research
Overexpression of RACK1 Predicts Poor Prognosis in Melanoma
This study aimed to investigate the expression of RACK1 in patients with melanoma and to reveal its possible functions in melanoma cells. The expression profiles of RACK1 detected in tumor tissues from melanoma patients showed that RACK1 was higher in tumor tissues, and its expression level was well associated with the clinical progression of melanoma (TNM stage, P=0.009). Furthermore, RNA interfering (RNAi) knockdown of RACK1 could efficiently suppress the proliferation, migration and invasion of A375 and A875 cells and promote their apoptosis. Taken together, these results suggest that RACK1 may be a poor prognostic fact...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Congcong Shen, Hui Hua, Lixiong Gu, Shuanglin Cao, Hengji Cai, Xiaodong Yao, Xiaodong Chen Tags: Research Paper Source Type: research
The association of RAN and RANBP2 gene polymerphisms with Wilms tumor risk in Chinese children
In this study, three potentially functional polymorphisms (rs56109543 C>T, rs7132224 A>G, and rs14035 C>T) in the RAN and one (rs2462788 C>T) in the RANBP2 were chosen to investigate their association with Wilms tumor susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to assess the association of the selected polymorphisms with Wilms tumor susceptibility. Results shown that RAN rs7132224 AG/GG genotypes significantly increased Wilms tumor risk when compared to AA genotype (adjusted OR=1.40, 95% CI=1.01-1.95, P=0.047). Carriers of 1-3 risk genotypes have a significantly higher Wilm...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaokai Huang, Jie Zhao, Wen Fu, Jinhong Zhu, Susu Lou, Xiaoqian Tian, Shanshan Chen, Jichen Ruan, Jing He, Haixia Zhou Tags: Research Paper Source Type: research
High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma
Conclusions: CXCR4 was commonly expressed in lung ASC tumors. High CXCR4 expression might be a novel marker in predicting a poor prognosis in resected lung ASC and might serve as a potential therapeutic target. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Qiaoliang Zhu, Rongkui Luo, Jie Gu, Yingyong Hou, Zongwei Chen, Fengkai Xu, Lin Wang, Wei Mao, Chunlai Lu, Di Ge Tags: Research Paper Source Type: research
FGF14 Functions as a Tumor Suppressor through Inhibiting PI3K/AKT/mTOR Pathway in Colorectal Cancer
In this study, we aimed to investigate the epigenetic regulation, biological function and molecular mechanism of FGF14 in CRC. The expression of FGF14 in CRC cell lines, normal human colon epithelial cell line, CRC tissues and paired adjacent normal tissues was detected by PCR and Western blot. The biological function of FGF14 in CRC was interrogated by cell viability assay, colony formation, flow cytometry, cell invasion and migration assay, as well as in vivo study. We found FGF14 was downregulated or silenced in all (10/10) CRC cell lines, while it was expressed in normal colonic tissues and normal human colon epithelia...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Tianhong Su, Linlin Huang, Ning Zhang, Sui Peng, Xiaoxing Li, Guangyan Wei, Ertao Zhai, Zhirong Zeng, Lixia Xu Tags: Research Paper Source Type: research
Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases
S100A10 is a small molecular weight protein expressed in the cytoplasm of many cells and one of the members of the S100 protein family that binds calcium and forms the largest subgroup of EF-hand proteins. The regulatory processes of S100A10 are complicated. S100A10 participates in the regulation of a variety of tumor and non-tumor diseases through cascade reactions with multitudinous signaling molecules. In malignant tumors, such as acute promyelocytic leukemia (APL) and lung cancer, S100A10 is likely involved in their progression, including invasion and metastasis through the regulation of plasmin production and subseque...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Chunyuan Li, Yi Ma, Fei Fei, Minying Zheng, Zugui Li, Qi Zhao, Jiaxing Du, Kai Liu, Rui Lu, Shiwu Zhang Tags: Review Source Type: research
STAT3 signaling in ovarian cancer: a potential therapeutic target
Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3 (STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently overexpressed in a wide range of cancer cells as well as clinical specimens, promoting tumor progression. It is widely accepted that STAT3 regulates a variety of cellular processes, such as tumor cell growth, survival, invasion, cancer stem cell-like characteristic, angiogenesis and drug-resistance. In this review, we focus on the role of STAT3 in tumorigenesis in ovarian cancer and discuss the existing inhibitors of STAT3 signaling that can be promisi...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Renba Liang, Xishan Chen, Li Chen, Fangzhu Wan, Kaihua Chen, Yongchu Sun, Xiaodong Zhu Tags: Review Source Type: research
The Antipsychotic Agent Sertindole Exhibited Antiproliferative Activities by Inhibiting the STAT3 Signaling Pathway in Human Gastric Cancer Cells
Gastric cancer (GC) is the third leading cause of cancer-related death. Although the therapeutic approaches have improved, the 5-year survival rate of GC patients after surgical resection remains low due to the high rates of metastasis and recurrence. Patients with schizophrenia have significantly lower incidences of cancer after long-term drug treatment, suggesting the potential or partially ameliorate the risk of cancer development of antipsychotic drugs. The goal of this study was to explore antipsychotic drugs with an optional effective therapy against gastric cellular carcinoma. We found that sertindole, an atypical a...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Chunyan Dai, Pei Liu, Xi Wang, Yifei Yin, Weiyang Jin, Li Shen, Yuzong Chen, Zhe Chen, Yiping Wang Tags: Research Paper Source Type: research
MiR-129-5p sensitization of lung cancer cells to etoposide-induced apoptosis by reducing YWHAB
Conclusion: Overexpression of expression miR-129-5p contributes to etoposide-induced lung cancer apoptosis by modulating YWHAB. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Chengshan Xu, Zhongli Du, Simei Ren, Xiaoshuan Liang, Huihui Li Tags: Research Paper Source Type: research
Interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of 4330 Chinese patients with gastrointestinal tract cancer
Conclusions: Our findings indicate a synergistic interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of gastrointestinal tract cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Dan Hu, Xinran Zhang, Xiandong Lin, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Feng Peng, Wenquan Niu Tags: Research Paper Source Type: research
Signatures of circulating microRNA in four sarcoma subtypes
Background: Sarcomas are rare malignant tumors of mesenchymal origin. The discovery of circulating biomarkers with high diagnostic value could supplement diagnosis of this heterogenous group of tumors. The aim of this study was to identify the profiles of circulating miRNA (c-miRNAs) in four groups of common bone and soft tissue sarcomas.Methods: At the time of diagnosis, blood samples were collected from 86 patients: 36 with locally advanced/unresectable/metastatic gastrointestinal stromal tumor (GIST) who received first-line treatment with imatinib; 16 with locally advanced osteosarcoma (OS); 26 with locally advanced syn...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hanna Kosela-Paterczyk, Agnieszka Paziewska, Maria Kulecka, Aneta Balabas, Anna Kluska, Michalina Dabrowska, Magdalena Piatkowska, Natalia Zeber-Lubecka, Filip Ambrozkiewicz, Jakub Karczmarski, Michal Mikula, Piotr Rutkowski, Jerzy Ostrowski Tags: Research Paper Source Type: research
An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients
The clinical applicability of the whole-exome sequencing (WES) in estimating tumor mutational burden (TMB) is currently limited by high cost, time-consuming and tissue availability. And given to the differences in the mutational landscapes among different types of cancer, we aimed to develop a cancer-specific signature to estimate TMB for right-sided colon cancer patients (RCC). Using WES data of 315 RCC patients, we identified the exons in which the number of mutational sites of the coding DNA sequences associated with TMB through linear regression analysis. Then, among these exons, we extracted a signature composed by 10...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wenbing Guo, Yelin Fu, Liangliang Jin, Kai Song, Ruihan Yu, Tianhao Li, Lishuang Qi, Yunyan Gu, Wenyuan Zhao, Zheng Guo Tags: Research Paper Source Type: research
DNA sensors, crucial receptors to resist pathogens, are deregulated in colorectal cancer and associated with initiation and progression of the disease
Conclusions: Our study revealed that the expression of multiple DNA sensors was deregulated in CRC and might be involved in tumor development. More importantly, the study identified that, among all these DNA sensors, AIM2, DAI, and DDX60 could be potentially critical for diagnosis, prognosis, and therapy of CRC and deserve further investigation. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Liangmei He, Yuxia Liu, Weiling Lai, Hongbo Tian, Lingxia Chen, Lu Xie, Zhiping Liu Tags: Research Paper Source Type: research
Comprehensive investigation of p53, p21, nm23, and VEGF expression in hepatitis B virus-related hepatocellular carcinoma overall survival after hepatectomy
Conclusion: Our findings suggested that VEGF might be a prognostic indicator of HBV-related HCC, and we also identified the VEGF prospective molecular mechanisms through the whole genome co-expression and GSEA approaches. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Guang-Zhi Zhu, Xi-Wen Liao, Xiang-Kun Wang, Yi-Zhen Gong, Xiao-Guang Liu, Long Yu, Chuang-Ye Han, Cheng-Kun Yang, Hao Su, Ke-Tuan Huang, Ting-Dong Yu, Jian-Lu Huang, Jia Li, Zhi-Ming Zeng, Wei Qin, Zheng-Qian Liu, Xin Zhou, Jun-Qi Liu, Lei Lu, Quan-Fa Han Tags: Research Paper Source Type: research
miR-125b-5p/STAT3 Pathway Regulated by mTORC1 Plays a Critical Role in Promoting Cell Proliferation and Tumor Growth
Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) plays a critical role in tumorigenesis. However, the precise underlying mechanism is still not fully understood. Although accumulating evidence suggests that mTORC1 signaling is regulated by microRNAs (miRNAs), whether miRNAs are involved in the tumorigenesis mediated by mTORC1 dysregulation remains largely unclear. In our study, the comparison between tuberous sclerosis complex 1 (Tsc1) -/- or Tsc2-/- mouse embryonic fibroblasts (MEFs) and the control cells revealed the involvement of microRNA-125b-5p (miR-125b-5p) in the tumorigenesis driven by m...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Chengcheng Zhang, Xiaofeng Wan, Sisi Tang, Kun Li, Yani Wang, Yujie Liu, Quan Sha, Xiaojun Zha, Yehai Liu Tags: Research Paper Source Type: research
The BRAF V600E mutation is a predictor of the effect of radioiodine therapy in papillary thyroid cancer
Objective: To investigate the correlation between the BRAF V600E gene mutation and clinicopathological features and thyroid function after iodine-131 treatment in patients with papillary thyroid cancer (PTC).Methods: A total of 128 PTC patients who underwent iodine-131 treatment after a total thyroidectomy from February 2015 to November 2016 at Hunan Cancer Hospital, China, were recruited. There were 25 males and 103 females. The age range was 11 to 73 years old. The BRAF V600E mutation in tumor tissues was detected by amplification-restriction mutation system polymerase chain reaction (ARMS-PCR), and the serum levels of T...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Junshang Ge, Jie Wang, Hui Wang, Xianjie Jiang, Qianjin Liao, Qian Gong, Yongzhen Mo, Xiaoling Li, Guiyuan Li, Wei Xiong, Jin Zhao, Zhaoyang Zeng Tags: Research Paper Source Type: research
LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A
Pancreatic cancer is a highly invasive malignant tumor of the digestive system. To explore the mechanism of pancreatic cancer development, development, invasion and metastasis, in this study we focused on long non-coding RNA (LncRNA), which has been reported to be involved in tumorigenesis. We identified a LINC00673, which is highly correlated with the pancreatic cancer risk. LINC00673 Overexpression is associated with good survival in pancreatic cancer patients, Effects of LINC00673 on pancreatic cancer cell apoptosis, viability, migration. LINC00673 negatively correlated with miR-504 and MiR-504 overexpression promoted c...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yi Gong, Hai-su Dai, Jun-jie Shu, Wei Liu, Ping Bie, Lei-da Zhang Tags: Research Paper Source Type: research
A Stemness and EMT Based Gene Expression Signature Identifies Phenotypic Plasticity and is A Predictive but Not Prognostic Biomarker for Breast Cancer
In this study we asked whether an mRNA based gene signature identifying these two cell types would explain variation in stemness, EMT, drug sensitivity, and prognosis in silico and in vitro. Main methods: In silico analyses were performed using publicly available cell line and patient tumor datasets. In vitro analyses of phenotypic plasticity and drug responsiveness were obtained using human breast cancer cell lines. Key findings: We find a novel gene list (CNCL) that can generate both categorical and continuous variables corresponding to the stemness/EMT (epithelial to mesenchymal transition) state of tumors. We are prese...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Muhammad Waqas Akbar, Murat Isbilen, Nevin Belder, Secil Demirkol Canli, Baris Kucukkaraduman, Can Turk, Ozgur Sahin, Ali Osmay Gure Tags: Research Paper Source Type: research
Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer
Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor in the connection between glycolysis and the tricarboxylic acid cycle. Restoring the mitochondrial OXPHOS function by inhibiting glycolysis through targeting PDK1 has become a hot spot for tumor therapy. However, the specific mechanism by which metabolic changes affect mitochondrial function remains unclear. Recent studies have found that mitochondrial quality control such as mitochondrial protein homeostasis plays an important role in maintaining mitochondrial function. Here, we focused on PDK1 and explored the specific mechanism by which metabolic changes affect mito...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xinyue Deng, Quan Wang, Meiyu Cheng, Yingying Chen, Xiaoyu Yan, Rui Guo, Liankun Sun, Yang Li, Yanan Liu Tags: Research Paper Source Type: research
Consistency Analysis of Programmed Death-Ligand 1 Expression between Primary and Metastatic Non-Small Cell Lung Cancer: A Retrospective Study
Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD-L1 cancer therapies. However, the correlation of PD-L1 expression status between the primary and paired metastatic NSCLC is still not clear. The current study aims to address this specific issue.Materials and Methods: The PD-L1 expression of the primary and paired metastatic lesions from 110 patients with NSCLC was retrospectively evaluated by immunohistochemical assay using Anti-PD-L1 antibody, Clone 22C3. The results were assessed by the Tumor Proportion Score (TPS) using cutoff values of
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Luqiao Luo, Xinlan Luo, Wendan Chen, Chunyan Liang, Su Yao, Weihong Huang, Chao Liu, Yan Ge, Xingtao Lin, Zhi Li Tags: Research Paper Source Type: research
Role of Laparotomy-based Parameters in Assessment of Optimal Primary Debulking Surgery and Long-term Outcomes in Patients with Stage IIIC Epithelial Ovarian Cancer
We evaluated the ability of our two laparotomy-based models to predict optimal primary debulking surgery (PDS) and long-term outcomes of stage IIIC epithelial ovarian cancer (EOC). Data of 400 IIIC EOC patients who underwent laparotomy were retrospectively analyzed. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy were calculated for 10 parameters. The parameters with a specificity ≥75%, PPV ≥50%, and NPV ≥50% were included in the final predictive index value (PIV) model. Peritoneal cancer index (PCI) was calculated summarizing lesion size scores (LSS...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Mingyi Zhou, Danbo Wang, Zaiqiu Long, Yong Zhang, Jing Liu Tags: Research Paper Source Type: research
EIF4E regulates STEAP1 expression in peritoneal metastasis
Gastric cancer is the most prominent form of malignancy in China, and the high mortality associated with it is mostly due to peritoneal metastasis. We have previously elucidated that the RNA-binding protein poly r(C) binding protein 1 (PCBP1) and miR-3978 function as repressors of peritoneal metastasis, partially by downregulation of six-transmembrane epithelial antigen of the prostate 1 (STEAP1). We now show that STEAP1 is regulated at the level of cap-dependent translation initiation by phosphorylated eIF4E. Chemically inhibiting phosphorylation of eIF4E or genetic ablation of phosphorylated eIF4E inhibit translational u...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jun-nan Jiang, Yuan-yu Wu, Xue-dong Fang, Fu-jian Ji Tags: Research Paper Source Type: research