More attention should be paid to adult gastric cancer patients younger than 35 years old: extremely poor prognosis was found
Purpose: Several studies have reported controversial results about prognosis of gastric cancer in young age patients. The difference may partially result from variable definitions of young age. The aim of this study was to find out the relation between age and prognosis of gastric cancer patients, and to analyze the clinicopathological features and prognostic factors in young gastric cancer patients.Methods: Data queried for this analysis included GC patients from the Surveillance, Epidemiology, and End Results Program database from 1973 to 2014. Gastric cancer patients (N=79,505) diagnosed with an age≥18 were included....
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wen-Long Guan, Lu-Ping Yuan, Xiang-Lei Yan, Da-Jun Yang, Miao-Zhen Qiu Tags: Research Paper Source Type: research

The Prognostic Value of Pretreatment Plasma Fibrinogen in Urological Cancers: A Systematic Review and Meta-analysis
Objective: Growing evidence suggests pretreatment fibrinogen can serve as a prognostic marker in various malignancies. However, there are contradictory results about the prognostic role of fibrinogen in urological cancers. We conducted a meta-analysis to evaluate the association between pretreatment plasma fibrinogen and survival outcomes in urological cancers.Methods: After a systematic search of PubMed and Embase, we included 14 studies in our meta-analysis, and estimated hazard ratios (HRs) for overall survival (OS) and cancer-specific survival (CSS) using a fixed-effect model.Results: Our results indicate that pretreat...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Haifeng Song, Guanyu Kuang, Zhenan Zhang, Binglei Ma, Jie Jin, Qian Zhang Tags: Research Paper Source Type: research

Potential Mutations in Uveal Melanoma Identified Using Targeted Next-Generation Sequencing
This study included tumour samples and blood samples from 107 UM patients at Peking University Cancer Hospital & Institute. Clinical data were collected. DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) specimens. Using the HaloPlex Target Enrichment System (Agilent Technologies), NGS was performed to investigate mutations in a 35-gene panel composed of cancer-related genes.Results: Recurrent coding mutations were found in the known UM drivers GNAQ and GNA11. FOXO1, PIK3R1 and HIF1A were also found to harbour somatic mutations in more than 20% of patients, a result that may indicate previously undescribe...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jiayi Yu, Xiaowen Wu, Junya Yan, Jinyu Yu, Ting Yin, Jie Dai, Meng Ma, Tianxiao Xu, Huan Yu, Longwen Xu, Lu Yang, Zhiyuan Cheng, Zhihong Chi, Xinan Sheng, Lu Si, Chuanliang Cui, Jun Guo, Yan Kong Tags: Research Paper Source Type: research

Systemic inflammation score predicts survival in patients with intrahepatic cholangiocarcinoma undergoing curative resection
Inflammation has a critical role in the development and progression of cancers. We developed a novel systemic inflammation score (SIS) based on lymphocyte, monocyte, and CA19-9 and explored its prognostic value in intrahepatic cholangiocarcinoma (ICC). From January 2005 to December 2011, 322 consecutive ICC patients who underwent curative resection in our center were included in this study, and validated in a retrospective study of 126 patients enrolled from 2012 to 2014. Clinicopathological variables including preoperative serum CA19-9 and LMR were analyzed. The cutoff values of CA19-9 and LMR were determined based on rec...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yong Zhang, Shi-Ming Shi, Hua Yang, Liu-Xiao Yang, Zheng Wang, Xue-Dong Li, Dan Yin, Ying-Hong Shi, Ya Cao, Zhi Dai, Jian Zhou, Qing Chen Tags: Research Paper Source Type: research

Association of RAGE gene four single nucleotide polymorphisms with the risk, invasion, metastasis and overall survival of gastric cancer in Chinese
Conclusions: RAGE gene SNP rs1800625 was significantly associated with gastric cancer risk, and rs1800625 and rs184003 were related to tumor clinical stage, indicating that RAGE gene may be a gastric cancer-susceptibility gene. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Dan Hu, Qing Liu, Xiandong Lin, Hejun Zhang, Jinxiu Lin, Xiongwei Zheng, Feng Peng Tags: Research Paper Source Type: research

Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16
In conclusion, lycopene upregulates ZO-1 expression and downregulates claudin-1 expression through the activation of ERK, JNK and MTORC1 as well as the inhibition of autophagy in human cSCC cells. Our findings demonstrate that autophagy plays a key role in lycopene-mediated pharmacological effects. This study indicates that lycopene might be a useful chemopreventive agent against cSCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Suyun Bi, Li Li, Heng Gu, Min Li, Song Xu, Wenbo Bu, Mengli Zhang, Zhihai Zhou, Xu Chen Tags: Research Paper Source Type: research

First-line continual EGFR-TKI plus local ablative therapy demonstrated survival benefit in EGFR-mutant NSCLC patients with oligoprogressive disease
Conclusion: The current study suggested that the addition of LAT to EGFR-TKI could provide satisfactory survival benefit for EGFR-mutant NSCLC patients with oligoprogression during first-line EGFR-TKI treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qinghua Xu, Hui Liu, Shuyan Meng, Tao Jiang, Xuefei Li, Shixiong Liang, Shengxiang Ren, Caicun Zhou Tags: Research Paper Source Type: research

BCL6 Rearrangement Indicates Poor Prognosis in Diffuse Large B-cell Lymphoma Patients: A Meta-analysis of Cohort Studies
BCL6 (3q27) rearrangement is the most frequent chromosomal abnormality in diffuse large B-cell lymphoma (DLBCL). Previously, studies on the association between BCL6 rearrangement and DLBCL outcome remain controversial. Here we systematically reviewed literatures to identify the prognostic significance of BCL6 rearrangement in DLBCL. Meta-analytic methods are used to obtain pooled estimates of the association between BCL6 rearrangement and prognosis in DLBCL patients treated with different chemotherapy regimens. A total of 22 studies are enrolled in the cohort, involving 3037 patients. BCL6 rearrangement is verified to be n...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shu Li, Zhan Wang, Liming Lin, Zhaoxing Wu, Qingfeng Yu, Feiqiong Gao, Jiawei Zhang, Yang Xu Tags: Research Paper Source Type: research

Inhibition of malignant human bladder cancer phenotypes through the down-regulation of the long non-coding RNA SNHG7
There is abundant evidence that long non-coding RNAs play important roles in the development of tumors. In the present study, our main aim was to explore the relationship between lncRNA SNHG7 and human bladder cancer cells, thus finding a novel target for bladder cancer therapy and diagnosis. Expression of lncRNA SNHG7 was evaluated using real-time quantitative polymerase chain reaction in bladder tumor tissues and paired adjacent normal tissues from 72 patients diagnosed with urothelial bladder carcinoma. We analyzed the differences in expression according to grading and staging. Human bladder cancer cell lines UMUC, 5637...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Congjie Xu, Jiaquan Zhou, Yang Wang, Anfang Wang, Liangju Su, Shuan Liu, Xinli Kang Tags: Research Paper Source Type: research

MicroRNA-449a Inhibits Tumor Metastasis through AKT/ERK1/2 Inactivation by Targeting Steroid Receptor Coactivator (SRC) in Endometrial Cancer
Endometrial cancer represents the leading frequency in gynecological malignancy in developed countries. Even with early detection, metastasis and recurrence remain the main reasons for a high death rate. MicroRNA-449a (miR-449a) has been reported to function as a tumor suppressor, yet the role of miR-449a in endometrial cancer metastasis has not been investigated. The present study identified that miR-449a was downregulated in advanced endometrial cancer. Overexpression of miR-449a decreased the migration and invasion of KLE and AN3CA endometrial cancer cells. Using luciferase reporter assays, we identified that miR-449a d...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yuan Hu, An-Yue Wu, Cong Xu, Ke-Qi Song, Wen-Jing Wang, Xia Yin, Wen Di, Zu-Bei Hong, Li-Hua Qiu Tags: Research Paper Source Type: research

Prognostic Significance of Young Age and Non-Bone Metastasis at Diagnosis in Patients with Metastatic Prostate Cancer: a SEER Population-Based Data Analysis
This study compared the clinicopathological features and survival of metastatic prostate cancer (mPCa) after stratification by age and non-bone-related metastasis to identify prognostic factors.Methods: Patients with mPCa between 2010 and 2015 were identified from the Surveillance, Epidemiology and End Results database and analyzed. The overall survival (OS) rate was assessed using the Kaplan-Meier curve and log-rank test as well as multivariate Cox regression analysis.Results: Among the 10147 patients with mPCa, 5378 were classified as young (≤70 years), 3140 were classified as middle-aged (70-82 years), and 1629 were ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yadong Guo, Shiyu Mao, Aihong Zhang, Ruiliang Wang, Ziwei Zhang, Junfeng Zhang, Longsheng Wang, Wentao Zhang, Yuan Wu, Lin Ye, Bin Yang, Xudong Yao Tags: Research Paper Source Type: research

A randomised trial of probiotics to reduce severity of physiological and microbial disorders induced by partial gastrectomy for patients with gastric cancer
Gastrectomy has been widely used for the treatment of gastric cancer, and the severity of physiological and microbial disorders has greatly harmed the health of patients. In the present study, a probiotic combination containing Bifidobacterium infantis, Lactobacillus acidophilus, Enterococcus faecalis and Bacillus cereus was used to reduce the physiological disorders induced by gastrectomy via monitoring the blood index and microbial diversity using high-throughput sequencing. Our results indicated that the probiotic combination had significantly reduced the inflammation indexes (leukocyte) (p
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Cihua Zheng, Tingtao Chen, Yuqing Wang, Yuan Gao, Yao Kong, Zhaoxia Liu, Xiaorong Deng Tags: Research Paper Source Type: research

LRP1B Polymorphisms Are Associated with Multiple Myeloma Risk in a Chinese Han Population
In this study, we evaluated the association between rs61070260 in LRP1B and MM risk in a Chinese Han population involving 739 MM patients and 592 healthy controls. Our results indicated that rs61070260 in LRP1B was significantly associated with MM susceptibility (P=3.937×10-37). Furthermore, the linkage disequilibrium (LD) analysis of rs61070260 revealed an LD block encompassing exons 26, 27 and 28 of the LRP1B gene, and a subsequent sequencing analysis identified three SNPs (rs762074421, rs756168629, rs113600691) in exons 26 and 28 of LRP1B. For the SNP rs756168629 in exon 26, a missense mutation which results in a ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bingjie Li, Chenxi Liu, Guixue Cheng, Mengle Peng, Xiaosong Qin, Yong Liu, Yongzhe Li, Dongchun Qin Tags: Research Paper Source Type: research

Nomogram Predicting Cause-Specific Mortality in Nonmetastatic Male Breast Cancer: A Competing Risk Analysis
Conclusion: The competing risk nomogram showed good accuracy for predictive prognosis in nonmetastatic MBC patients. It was a useful implement to evaluate crude mortalities of BCSD and OCSD, and help clinicians to choose appropriate therapeutic plans. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wei Sun, Minghua Cheng, Huaqiang Zhou, Wenqi Huang, Zeting Qiu Tags: Research Paper Source Type: research

Pretreatment albumin globulin ratio has a superior prognostic value in laryngeal squamous cell carcinoma patients: a comparison study
Conclusion: AGR might be a promising marker to better predicting prognosis of LSCC patients. Future studies are warranted to validate our finding. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Tao Zhou, Shi-Tong Yu, Wan-Zhi Chen, Rong Xie, Ji-Chun Yu Tags: Research Paper Source Type: research

The survival benefit of palliative gastrectomy and/or metastasectomy in gastric cancer patients with synchronous metastasis: a population-based study using propensity score matching and coarsened exact matching
This study was aimed to evaluate survival benefit of palliative surgeries to gastric and/or metastatic tumors in mGC patients based on U.S population.Materials and Methods: A total of 8345 gastric cancer patients diagnosed with synchronous distal metastasis between 2004 to 2013 from the Surveillance, Epidemiology, and End Results Program (SEER) database were divided into four groups according to surgery strategies: surgeries to both primary and metastatic tumors (SPM), gastrectomy only (GO), metastasectomy only (MO) and no surgery performed (NS). Their clinicopathological characteristics and overall survival (OS) were anal...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lu-Ping Yang, Zi-Xian Wang, Ming-Ming He, Ying Jin, Chao Ren, Zhi-Qiang Wang, Feng-Hua Wang, Yu-Hong Li, Feng Wang, Rui-Hua Xu Tags: Research Paper Source Type: research

Long Noncoding RNAs Serve as Potential Diagnostic Biomarkers for Colorectal Cancer
Conclusions: The accuracy of lncRNAs for CRC diagnosis is high, and lncRNAs could be functioned as promising candidates for CRC diagnosis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Juan Cai, Xueliang Zuo, Zhiqiang Chen, Yao Zhang, Jinguo Wang, Junfeng Wang, Xiaobing Ye, Wenying Zhao Tags: Research Paper Source Type: research

Prevalence and prognostic impact of synchronous distant metastases in patients with hypopharynx squamous cell carcinomas: a SEER-based study
Conclusion: This is the first SEER analysis assessing prevalence and prognostic impact of synchronous distant metastases in a large cohort of patients with hypopharynx SCC. Poorer prognosis was associated with elderly patients, higher T category, advanced N category, posterior wall of hypopharynx cancers, no surgery therapies to the primary tumor and more metastatic sites (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yujiao Li, Xiaomin Ou, Chaosu Hu Tags: Research Paper Source Type: research

The impact of SPARC expression on the survival of pancreatic ductal adenocarcinoma patients after curative resection
Conclusions: The stromal SPARC expression in resectable pancreatic cancer patients might be useful as a prognostic marker. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Masaaki Murakawa, Toru Aoyama, Yohei Miyagi, Satoshi Kobayashi, Makoto Ueno, Manabu Morimoto, Masakatsu Numata, Naoto Yamamoto, Hiroshi Tamagawa, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Soichiro Morinaga Tags: Research Paper Source Type: research

Radial probe endobronchial ultrasound assisted conventional transbronchial needle aspiration in the diagnosis of solitary peribronchial pulmonary lesion located in the segmental bronchi
Conclusions: The combination of R-EBUS with C-TBNA was advantageous and safe for the diagnosis of solitary peribronchial pulmonary lesions located in the segmental bronchi. However, possible bleeding complications should be anticipated with needle aspiration. Further verification of this combined application should be investigated in larger clinical trials. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhiang Huang, Haidong Huang, Yunye Ning, Jin Han, Yibo Shen, Hui Shi, Qin Wang, Chong Bai, Qiang Li, Simoff Michael, Paul Zarogoulidis, Wolfgang Hohenforst-Schmidt, Fotis Konstantinou, J. Francis Turner, Charilaos Koulouris, Athanasios Katsaounis, Aikater Tags: Research Paper Source Type: research

Advances in Identification of Susceptibility Gene Defects of Hereditary Colorectal Cancer
Colorectal cancer (CRC) is a common malignant tumor of the digestive system worldwide, associated with hereditary genetic features. CRC with a Mendelian genetic predisposition accounts for approximately 5-10% of total CRC cases, mainly caused by a single germline mutation of a CRC susceptibility gene. The main subtypes of hereditary CRC are hereditary non-polyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP). With the rapid development of genetic testing methods, especially next-generation sequencing technology, multiple genes have now been confirmed to be pathogenic, including DNA repair or DNA mism...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qiang Liu, Yue-Qiu Tan Tags: Review Source Type: research

Prognostic and Clinicopathological Significance of MiR-155 in Hematologic Malignancies: A Systematic Review and Meta-analysis
Background: Aberrant miR-155 expression has been reported in various types of hematologic malignancies. However, the prognostic and clinicopathological value of miR-155 remains unclear. Here, we performed this systemic review and meta-analysis to comprehensively evaluate the prognostic and clinicopathological significance of miR-155 expression in hematologic malignancies.Methods: We systematically searched the PubMed, EMBASE, ISI Web of Science, Cochrane library databases and OVID to identify eligible studies published from Jan 1, 2008 to Aug 1, 2018. The pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lu Tang, Yi-zhong Peng, Cheng-gong Li, Hui-wen Jiang, Heng Mei, Yu Hu Tags: Review Source Type: research

Transarterial Chemoembolization related to Good Survival for Selected Patients with advanced Hepatocellular Carcinoma
Conclusion: We found four risk factors were associated with dismal overall survival for advanced HCC patients: serum GGT level, serum CRP, serum ALP and presence of PVTT. TACE may be recommended for patients with advanced HCC with 0-1 risk factors due to the favourable prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yong Le, Jing-Xian Shen, Yong-Fa Zhang, Min-Ke He, Anna Kan, Hai-Long Chen, Zi-Shan Yu, Qi-Jiong Li, Ming Shi Tags: Research Paper Source Type: research

Long noncoding RNA GIHCG functions as an oncogene and serves as a serum diagnostic biomarker for cervical cancer
This study also suggested that GIHCG may be a non-invasive diagnostic biomarker and a potential therapeutic target for cervical cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaolian Zhang, Lihua Mao, Lihua Li, Zhihong He, Naiqun Wang, Yanfeng Song Tags: Research Paper Source Type: research

Clinical Significance of Gender and Body Mass Index in Asian Patients with Colorectal Cancer
This study aimed to evaluate the clinical relevance of gender and body mass index (BMI) with colorectal cancer using a Korean nationwide cohort.Methods: Data of colorectal cancer cohorts between 2012 and 2013 were acquired from the Health Insurance Review and Assessment Service. All patients underwent surgery due to colorectal cancers. Stage IV patients were excluded due to possible clinical heterogeneity. BMI was classified with the World Health Organization criteria.Results: A total of 31,756 patients were analyzed. The underweight group had 33% higher risk of stage III disease (p
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chai Hong Rim, Chul Yong Kim, Dae Sik Yang, Won Sup Yoon Tags: Research Paper Source Type: research

Loss of Yes-associated Protein Represents an Aggressive Subtype of Colorectal Cancer
This study was designed to investigate the clinical significance of YAP in CRC.Methods: We selected 206 eligible patients diagnosed with CRC from 2003 to 2007. Tissue microarray (TMA) blocks were made from 206 formalin-fixed paraffin-embedded CRC tissues and 158 corresponding normal colonic tissues. Using the TMA blocks, we performed immunohistochemical staining of YAP and assessed its expression status in different subcellular locations. The patients were divided into four groups according to the expression status of YAP in the cytoplasm and nucleus. Statistical analysis was performed to explore the correlation between YA...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sheng Zhang, Qing Wei, Yongzhi Yang, Huanlong Qin, Xinxiang Li, Sanjun Cai, Yanlei Ma Tags: Research Paper Source Type: research

Multi-omics Perspective on the Tumor Microenvironment based on PD-L1 and CD8 T-Cell Infiltration in Urothelial Cancer
Conclusions: The classification of bladder cancer into four TMITs on the bases of the PD-L1 expression and the CD8+ CTLs statuses is an appropriate approach for bladder tumor immunotherapy. TMIT I (high PD-L1/high CD8A) is significantly correlated with more somatic mutation burden, and facilitates CD8+ T-cell infiltration and activates T-effector and IFN-γ associated gene signature. Alteration landscape for somatic variants was different between TMIT I and TMIT II (low PD-L1/low CD8A). (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Siteng Chen, Ning Zhang, Jialiang Shao, Tao Wang, Xiang Wang Tags: Research Paper Source Type: research

Impact of clinical and pathological factors on local recurrence after breast-conserving treatment: CT-based localization for a tumor bed boost yielded better local control when compared with a surgical scar
Conclusions: The use of CT information during boost field planning could reduce the risk of LR among patients undergoing BCT. Neoadjuvant and adjuvant treatments for breast cancer did not show the significant difference in respect to the outcome of LR. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lize Wang, Jinfeng Li, Tianfeng Wang, Yuntao Xie, Zhaoqing Fan, Yingjian He, Tao Ouyang Tags: Research Paper Source Type: research

New Prospect for Cancer Cachexia: Medical Cannabinoid
Cachexia is a common term for the wasting symptoms which may appear in almost every chronic illness, such as AIDS, tuberculosis, and cancer. Cancer cachexia (CCA) is a result of the interaction between the host and the tumor, mainly manifested in short-term wasting, malnutrition, and so on. Due to the chronic food shortages, absorption dysfunction and metabolic disorders, all of these eventually lead to hypoimmunity, organ failure, and higher susceptibility to pathogenic microorganisms. And then increased morbidity and mortality rates as well as reduced tolerance to anti-cancer treatments will be resulted in patients with ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jing Wang, Yanling Wang, Mengting Tong, Hongming Pan, Da Li Tags: Review Source Type: research

The Oncogenic Potential of SUV39H2: A Comprehensive and Perspective View
Epigenetic modifications at the histone level have attracted significant attention because of their roles in tumorigenesis. Suppressor of variegation 3-9 homolog 2 (SUV39H2, also known as KMT1B) is a member of the SUV39 subfamily of lysine methyltransferases (KMTs) that plays a significant role in histone H3-K9 di-/tri-methylation, transcriptional regulation and cell cycle. Overexpressions of SUV39H2 at gene, mRNA and protein levels are known to be associated with a range of cancers: leukemia, lymphomas, lung cancer, breast cancer, colorectal cancer, gastric cancer, hepatocellular cancer and so on. Accumulating evidence in...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Baihui Li, Yu Zheng, Lili Yang Tags: Review Source Type: research

The survival benefit of intensified full-dose XELOX chemotherapy concomitant to radiotherapy and then resting-period consolidation chemotherapy in locally advanced rectal cancer
Conclusions: The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was well tolerated in our cohort and provided a promising long-term oncologic outcome, which warranted further investigation in a randomize trails. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Rong Zheng, ShiFeng Lian, XiaoXue Huang, GuoXian Guan, XiaoBo Li, Pan Chi, BenHua Xu Tags: Research Paper Source Type: research

Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis
Papillary thyroid carcinoma (PTC) is the most commonly diagnosed endocrine cancer, and those with BRAFV600E mutation have high recurrence rate and less favorable clinical behavior. Genistein having anti-carcinoma effects in various types of carcinomas as an estrogen analog, but the mechanism of Genistein in the progression of PTC remains unknown. Genistein significantly inhibits the proliferation and the invasion (P
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chunyan Zhang, Bin Lv, Cuihua Yi, Xiujie Cui, Shaofeng Sui, Xueen Li, Mei Qi, Chunyan Hao, Bo Han, Zhiyan Liu Tags: Research Paper Source Type: research

High FOXM1 expression is a prognostic marker for poor clinical outcomes in prostate cancer
Purpose: We aimed to investigate the expression of FOXM1 and to determine the relationships between FOXM1 expression and clinicopathologic characteristics in patients with PCa. Furthermore, we reconfirmed the prognostic impact of FOXM1 in different cohorts using already published data.Patients and Methods: Formalin-fixed, paraffin-embedded tissues were collected from patients with low- (n=17), intermediate- (n=36), and high-risk (n=29) disease, from patients with CRPC (n=2) and from patients with BPH (n=28). To analyze FOXM1 expression, we performed IHC analyses. Also, we analyzed gene expression data from cBioPortal to ev...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mee Young Kim, Ae Ryang Jung, Ga Eun Kim, Jonghyup Yang, U-Syn Ha, Sung-Hoo Hong, Yeong Jin Choi, Mi Hyoung Moon, Sae Woong Kim, Ji Youl Lee, Yong Hyun Park Tags: Research Paper Source Type: research

Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis
In this study, we found that both reduced vitamin C and oxidized vitamin C (DHA) could selectively suppress the viability of ER6 cells. DHA was efficient in inhibiting glycolysis and leading to energy crisis, which could be one mechanism for overcoming drug resistance to erlotinib of ER6 cells. Our data suggest that applying DHA could be a novel treatment strategy for NSCLC with acquired resistance to targeted therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mingtong Ye, Nengzhi Pang, Ting Wan, Yuanling Huang, Tianyi Wei, Xuye Jiang, Yujia Zhou, Yufeng Huang, Hainan Yang, Zhenfeng Zhang, Lili Yang Tags: Research Paper Source Type: research

Can high school students help to improve breast radiologists in detecting missed breast cancer lesions on full-field digital mammography?
Conclusions: Contrast-enhanced mammography evaluated by non-experienced high school students might improve detection rate of breast cancer when compared to evaluations of only full-field digital mammography by radiologists. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: T.J.A. van Nijnatten, M.L. Smidt, B. Goorts, S. Samiei, I. Houben, E.M. Kok, J.E. Wildberger, S.G.F. Robben, M.B.I. Lobbes Tags: Research Paper Source Type: research

Nomogram for predicting level V lymph node metastases in papillary thyroid carcinoma with clinically lateral lymph node metastases: A large retrospective cohort study of 1037 patients from FDUSCC
Objective: Extensive lateral neck dissection (LND), especially routine level V dissection, may potentially increase morbidity and have no significant benefit to survival in patients with papillary thyroid carcinoma (PTC). Our study aimed to determine the pattern and risk factors for level V lymph node metastasis (LNM) and to develop an assessment model based on a nomogram for predicting whether level V dissection is necessary.Methods: A total of 1037 PTC patients with clinically suspected LNM (N1b) who underwent total thyroidectomy (TT) with central LND and unilateral LND from 2011 to 2015 were retrospectively retrieved. U...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yunjun Wang, Qing Guan, Jun Xiang Tags: Research Paper Source Type: research

Surgical Compliance and Outcomes in Gastric Cancer: a population-based cohort study
Background: Surgical resection is one of curative treatment for gastric cancer (GC), however, a set of patients show poor surgical compliance in the USA. We aimed to identify the risk factors associated with surgical compliance and investigate the difference in survival.Methods: GC patients diagnosed between 1973 and 2014 were identified from the Surveillance Epidemiology and End Results (SEER) databases. Based on different surgical compliance and treatment regimen, patients were classified into three subgroups: surgical compliance group, surgical noncompliance group, and non-surgical group. Multivariable Logistic regressi...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guihua Liu, Ming Xu, Tingting Gao, Lingying Xu, Peijun Zeng, Haiying Bo, Fang Li, Wei Zhang, Zhengting Wang Tags: Research Paper Source Type: research

The Development and Future of Digestive Tract Reconstruction after Distal Gastrectomy: A Systemic Review and Meta-Analysis
Conclusion: This indirect comparison suggested some superiority of Roux-en-Y reconstruction after distal gastrectomy. Further perspective clinical trials are required to provide evidence for the optimal reconstruction skill. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xi-Jie Chen, Yun-Zhi Chen, Dong-Wen Chen, Ying-Liang Chen, Jun Xiang, Yi-jia Lin, Shi Chen, Jun-Sheng Peng Tags: Research Paper Source Type: research

VEGFR-TKIs combined with chemotherapy for advanced non-small cell lung cancer: A systematic review
Conclusions: Our study demonstrated that regimens with VEGFR-TKIs combined with chemotherapy improved PFS, ORR and DCR in patients with advanced NSCLC, but had no impact on OS. VEGFR-TKIs induced more frequent and serious AEs compared with control therapies. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lian Liu, Yue Zhang, Jia Wei, Zhaoxin Chen, Jing Yu Tags: Research Paper Source Type: research

Scar tissue to lung cancer; pathways and treatment
Lung cancer still remains diagnosed at a late stage although we have novel diagnostic techniques at our disposal. However; for metastatic disease we have novel therapies based on pharmacogenomics. Tumor heterogenity provides us different treatments. There are several reasons for carcinogenesis; fibrosis and scar tissue provides an environment that induces malignancy. In the current review we will try and elucidate the pathways involved from scar tissue to carcinogenesis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Konstantinos Sapalidis, Chrysanthi Sardeli, Efstathios Pavlidis, Georgios Koimtzis, Charilaos Koulouris, Nikolaos Michalopoulos, Stylianos Mantalovas, Theodora Tsiouda, Ioannis Passos, Christoforos Kosmidis, Dimitrios Giannakidis, Valeriu Surlin, Athanasi Tags: Review Source Type: research

KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients
In conclusion, only the KRAS G12V mutation has an adverse effect on patient survival. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xin-Hui Fu, Zhi-Ting Chen, Wen-Hui Wang, Xin-Juan Fan, Yan Huang, Xiao-Bin Wu, Jing-Lin Huang, Jing-Xuan Wang, Han-Jie Lin, Xiao-Li Tan, Lei Wang, Jian-Ping Wang Tags: Research Paper Source Type: research

The association between infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment
Purpose: To evaluate the infection incidence in breast cancer patients whether they have a major autoimmune disease or not.Methods: This retrospective cohort study compared the infection incidence of 174 breast cancer patients with an autoimmune disease, including Sjogren's Syndrome (SS), Rheumatoid Arthritis (RA), and Systemic Lupus Erythematosus (SLE), along with 4429 patients without an autoimmune disease, for the period 2000 to 2016. Six-hundred and ninety six, age-, stage-, and diagnosis era-matched patients without any autoimmune disease were analyzed to eliminate the effects of these confounding factors may have on ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chien-Chih Chen, Wei-Li Ho, Hsin-Hua Chen, Meei-Ling Sheu, Chiann-Yi Hsu, Jun-Peng Chen Tags: Research Paper Source Type: research

Prognostic value of preoperative hyponatremia in patients with epithelial ovarian cancer
Hyponatremia is an emerging issue in cancer patients. However, few studies have explored the prognostic value of preoperative hyponatremia in epithelial ovarian cancer (EOC) patients. We conducted a retrospective study of women diagnosed with EOC at Shengjing Hospital from 2011 to 2015. Preoperative serum sodium levels were measured and classified as normal (136-145 mmol/L) or hyponatremic (≤135 mmol/L) according to the average/most recent measurements of this biomarker. Multivariable Cox proportional hazard regression models were applied to determine the adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jing-Yi Guo, Ting-Ting Gong, Zhuo Yang, Yi Liu, Ling Wang, Ya-Nan Wang, Qi-Jun Wu Tags: Research Paper Source Type: research

Tripartite motif-containing 15 overexpression in non-small cell lung cancer is associated with poor patient prognoses
This study aimed to comprehensively investigate the differential expression and prognostic indicators of the tripartite motif-containing (TRIM) gene family in non-small cell lung cancer (NSCLC).Methods: The Cancer Genome Atlas (TCGA) Research Network and three datasets from Gene Expression Omnibus (GEO) database were used to assess TRIM gene family expression patterns in NSCLC. Quantitative real-time PCR and immunohistochemistry (IHC) were conducted to confirm differentially expressed genes (DEGs). Kaplan-Meier survival analysis and univariate Cox regression analysis were carried out to analyze the association between TRIM...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaoying Han, Cuicui Huang, Xiao Qu, Shaorui Liu, Xudong Yang, Yu Wang, Fenglong Bie, Qi Liu, Jiajun Du Tags: Research Paper Source Type: research

Comprehensive Analysis of Aberrantly Expressed ceRNA network in gastric cancer with and without H.pylori infection
Conclusion: Using TCGA database for data mining, we have successfully constructed a ceRNA regulatory network of GC with Hp infection, consisting of 10 lncRNAs, 11 miRNAs and 219 mRNAs. These findings might provide critical clues for the regulatory role of ceRNA network in the development of GC with Hp infection. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Aining Chu, Jingwei Liu, Yuan Yuan, Yuehua Gong Tags: Research Paper Source Type: research

Cadherin Related Family Member 2 Acts As A Tumor Suppressor By Inactivating AKT In Human Hepatocellular Carcinoma
In this study, we demonstrated that CDHR2 was highly expressed in para-cancer tissues of human hepatocellular carcinoma (HCC), but significantly downregulated or silenced in 85.7% (6/7) of HCC cell lines by both semi-quantitative PCR and western blot, and 79.1% (19/24) and 80.2% (89/111) of tumor tissues from patients with HCC by semi-quantitative PCR, and immunohistochemistry, respectively. Interestingly, CpG islands in the promoter of CDHR2 gene were hypermethylated in HCC cell lines and tissues compared with the para-cancer tissues by methylation-specific PCR analysis, leading to transcriptional repression and silencing...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ziyuan Xia, Meijin Huang, Qiangqiang Zhu, Yinghua Li, Qian Ma, Yang Wang, Xia Chen, Jianzhong Li, Lei Qiu, Junping Zhang, Jiaoyang Zheng, Bin Lu Tags: Research Paper Source Type: research

MYH9 Promotes Growth and Metastasis via Activation of MAPK/AKT Signaling in Colorectal Cancer
In this study, we detected significant MYH9 overexpression in CRC samples compared with paired normal tissues using western blotting and tissue microarray immunohistochemistry (IHC). Moreover, analysis of patient clinical information demonstrated that MYH9 overexpression was strongly correlated with lymph node metastasis and poor overall survival. Endogenous overexpression of MYH9 enhanced the ability of cell proliferation and migration in vitro, and accelerated CRC growth in mouse models. Silencing of MYH9 revealed repressive effects on CRC cells in vitro and in vivo. Furthermore, primary biomechanics that involved MAPK/A...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bin Wang, Xiaolong Qi, Jian Liu, Rui Zhou, Chuang Lin, Junjie Shangguan, Zhuoli Zhang, Liang Zhao, Guoxin Li Tags: Research Paper Source Type: research

The Impact of Afatinib on Survival in Advanced Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials
Conclusions: This meta-analysis confirmed that afatinib extended survival, improved response rates and did not increase the risk of treatment-related mortality in advanced NSCLC. As a novel EGFR-TKI, afitinib has significant potential for clinical application. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chi Wang, Yun Li, Li Ke, Lejie Cao, Pingsheng Fan, Zhiwei Wu, Quan Wu Tags: Research Paper Source Type: research

A network-based approach to identify DNA methylation and its involved molecular pathways in testicular germ cell tumors
Conclusion: Our study indicated possible aberrantly methylated-differentially expressed genes and pathways in TGCT by bioinformatics analysis, which may provide novel insights for unraveling pathogenesis of TGCT. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hao Bo, Ke Cao, Ruiling Tang, Han Zhang, Zhaojian Gong, Zhizhong Liu, Jianye Liu, Jingjing Li, Liqing Fan Tags: Research Paper Source Type: research

Regulatory sequence analysis of semaphorin 4D 5' non-coding region
Semaphorin 4D (Sema4D) has been proven to be one of the hypoxia effectors regulated by hypoxia inducible factor (HIF-1) in multiple cells, and play a role in angiogenesis like VEGF. However, the regulatory sequence characteristics of the Sema4D are not clarified. The possible hypoxia response element (HRE) sequences in 5' non-coding Region before ATG start codon of Sema4D were screened, followed by point mutagenesis and luciferase assay analysis. Sequencing and alignment of this region in 11 cancer cell lines and 4 normal cell lines were also performed, followed by cloning, mutation and luciferase assay analysis. The resul...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lijuan Qiu, Hongchao Jiang, Jia Luo, Juemin Xi, Xiaodan Wang, Yue Pan, Junying Chen, Yujiao Zhao, Qiangming Sun Tags: Research Paper Source Type: research