SIRT1 promotes formation of breast cancer through modulating Akt activity
In this study, we sought to make clear the regulating effects of SIRT1 in breast cancer cells, and to explore the underlying mechanisms through which SIRT1 regulates breast cancer. First, our results showed that SIRT1 was significantly up-regulated in breast cancer tissues and cells, which correlated with histological grade, tumor size, as well as lymph node metastasis. Then we established SIRT1-overexpressed and SIRT1- knockdown breast cancer cell lines to investigate the functions of SIRT1 in regulating colony formation, cell proliferation, cell cycle, cell apoptosis and migration. We found that overexpression of SIRT1 s...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiaoxia Jin, Yingze Wei, Feng Xu, Min Zhao, Kui Dai, Rong Shen, Shuyun Yang, Nong Zhang Tags: Research Paper Source Type: research

Higher Plasma Fibrinogen Levels are Associated with Malignant Phenotype and Worse Survival in Patients with Glioblastomas
In conclusion, plasma fibrinogen could predict clinical outcome and molecular subtype in GBMs. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Peng-Fei Wang, Zhe Meng, Hong-Wang Song, Kun Yao, Ze-Jun Duan, Shou-Wei Li, Chang-Xiang Yan Tags: Research Paper Source Type: research

Addition of chemotherapy to intensity-modulated radiotherapy does not improve survival in stage II nasopharyngeal carcinoma patients
In this study, we examined whether combining neoadjuvant chemotherapy (NAC) and/or concurrent chemotherapy (CC) with intensity-modulated radiotherapy (IMRT) improved survival in patients with stage II nasopharyngeal carcinoma (NPC). Two hundred forty-two stage II NPC patients were enrolled between May 2008 and April 2014 and received radical IMRT with simultaneous integrated boost technique using 6 MV photons; some patient groups also received chemotherapy every 3 weeks for 2-3 cycles. The median follow-up duration was 69 months for all patients. At the last follow-up, 18 patients had experienced treatment failure; locoreg...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wang Fangzheng, Jiang Chuner, Sun Quanquan, Ye Zhimin, Liu Tongxin, Liu Jiping, Masoto Sakamoto, Wu Peng, Shi Kaiyuan, Qin Weifeng, Fu Zhenfu, Jiang Yangming Tags: Research Paper Source Type: research

Detection of CTCs in portal vein was associated with intrahepatic metastases and prognosis in patients with advanced pancreatic cancer
Pancreatic cancer is amongst the most lethal malignancies with increasing incidence and mortality worldwide. Distant metastases, especially intrahepatic metastases, is the leading cause of death for pancreatic cancer. Circulating tumor cells (CTCs) are neoplastic cells released from the primary tumor into circulation, and play critical roles in metastases of various types of cancers. Though clinical studies showed that detection of CTCs in peripheral circulation was associated with worse prognosis in patients with breast cancer and hepatocellular carcinoma, detection CTCs in peripheral blood of pancreatic cancer was still ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiaoyu Liu, Changyu Li, Junhao Li, Tianzhu Yu, Guofeng Zhou, Jiemin Cheng, Guoping Li, Yang Zhou, Wenhui Lou, Xiaolin Wang, Gaoquan Gong, Lingxiao Liu, Yi Chen Tags: Research Paper Source Type: research

A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer
This study outlines the regulatory effects of oxaliplatin on miRNAs expression in colon cancer cells and correlates it with the changing microRNA expression with p53 and p73 expression status in cells. HCT116p53+/+ and HCT116p53-/- cells were exposed to oxaliplatin, and the cellular viability was determined by XTT. p73 was knocked down using siRNA and the tumor cells were then treated with oxaliplatin. The expression profile of 384 miRNAs was determined by TaqMan® human miRNA array and calculated by the ∆∆Ct method. Cellular viability was found to decrease after the treatment with oxaliplatin in a dose-dependent ma...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jasmine Evert, Surajit Pathak, Xiao-Feng Sun, Hong Zhang Tags: Research Paper Source Type: research

Impact of Interstitial Lung Disease Classification on the Development of Acute Exacerbation of Interstitial Lung Disease and Prognosis in Patients with Stage III Non-Small-Cell Lung Cancer and Interstitial Lung Disease Treated With Chemoradiotherapy
Conclusion: The incidence of AE of ILD was high in patients with stage III NSCLC and ILD treated with chemoradiotherapy as the first-line treatment. However, diagnosis of a non-UIP pattern could predict lower risk of AE of ILD and longer OS durations. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Haruki Kobayashi, Tateaki Naito, Katsuhiro Omae, Shota Omori, Kazuhisa Nakashima, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Toshiaki Takahashi Tags: Research Paper Source Type: research

A quantitative proteomic response of hepatocellular carcinoma Hep3B cells to danusertib, a pan-Aurora kinase inhibitor
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, but the overall prognosis remains disappointing especially in the advanced-stage patients. Aberration expression of Aurora kinases is tumorigenic and thus it has attracted interests as therapeutic targets in cancer treatment. Here, we investigated the proteomic response of HCC Hep3B cells to danusertib (Danu), a pan-Aurora kinase inhibitor, and then validated the proteomic results based on stable-isotope labeling by amino acids in cell culture (SILAC). The proteomic data identified that Danu modulated the expression of 542 protein molecules (279 up-r...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qiaohua Zhu, Xinfa Yu, Zhi-Wei Zhou, Meihua Luo, Chengyu Zhou, Zhi-Xu He, Yong Chen, Shu-Feng Zhou Tags: Research Paper Source Type: research

Histone methylation in DNA repair and clinical practice: new findings during the past 5-years
DNA double-strand breaks (DSBs) are highly toxic lesions that can impair cellular homeostasis and genome stability to result in tumorigenesis for inappropriate repair. Although DSBs are repaired by homologous recombination (HR) or non-homologous end-joining (NHEJ), the related mechanisms are still incompletely unclear. Indeed, more and more evidences indicate that the methylation of histone lysine has an important role in choosing the pathways of DNA repair. For example, tri-methylated H3K36 is required for HR repair, while di-methylated H4K20 can recruit 53BP1 for NHEJ repair. Here, we reviewed the recent progress in the ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shuhua Wei, Chunxiao Li, Zhongnan Yin, Jie Wen, Hui Meng, Lixiang Xue, Junjie Wang Tags: Review Source Type: research

Copy number variation and high expression of DNA topoisomerase II alpha predict worse prognosis of cancer: a meta-analysis
Background: Increasing numbers of literatures have investigated the association between TOP2A and cancer prognosis. But the results of the relationship between the two were inconclusive. The aim of this meta-analysis was to elucidate whether TOP2A could predict prognosis of cancer.Materials and Methods: A systematically searching for potentially valuable literature was conducted through electronic databases containing PubMed and Web of Science. Hazard Ratio (HR) and their 95% confidence interval (CI) were used to assess the strength of association between TOP2A and cancer prognosis.Results: Finally twenty-five studies were...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ling Ren, Jingwei Liu, Kaihua Gou, Chengzhong Xing Tags: Research Paper Source Type: research

Assessment of the Long-term Diagnostic Performance of a New Serological Screening Scheme in Large-scale Nasopharyngeal Carcinoma Screening
Conclusion: The new NPC screening scheme (PROB≥0.65) based on VCA/IgA and EBNA1/IgA outperforms the other seromarkers, and making it the preferred serodiagnostic strategy for long-term NPC screening in high-incidence areas. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xia Yu, Mingfang Ji, Weimin Cheng, Biaohua Wu, Yun Du, Sumei Cao Tags: Research Paper Source Type: research

A Nomogram for Distinction and Potential Prediction of Liver Metastasis in Breast Cancer Patients
In this study, totally 6238 patients from SEER database with known distant metastasis status and clinicopathologic variables were enrolled and divided randomly into training and validating groups. Logistic regression was used to screen variables and a nomogram was constructed. After multivariate logistic regression, sex, histology type, N stage, grade, age, ER, PR, HER2 status as significant variables for constructing the nomogram. The nomogram for distinguishing and predicting liver metastasis in breast cancer passed the calibration and validation steps and the areas under the receiver operating characteristic curve of th...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Zhenhai Lin, Shican Yan, Jieyun Zhang, Qi Pan Tags: Research Paper Source Type: research

A Prognostic Nomogram Incorporating Depth of Tumor Invasion to Predict Long-term Overall Survival for Tongue Squamous Cell Carcinoma With R0 Resection
Purpose: To establish a useful prognostic nomogram to predict long-term overall survival for patients with tongue squamous cell carcinoma (TSCC) after R0 resection.Patients and Methods: The nomogram was developed using a retrospective cohort of 235 TSCC patients from Sun Yat-sen University Cancer Center between 1 January 2000 and 31 December 2007. An independent dataset of 223 patients was used for external validation. Multivariate Cox proportional hazards model (backward selection; the Akaike information criteria) was applied to select variables for construction of the nomogram. Discrimination and calibration were perform...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Boyang Chang, Wenjun He, Hui Ouyang, Jingwen Peng, Lujun Shen, Anxun Wang, Peihong Wu Tags: Research Paper Source Type: research

Methylation patterns of RASA3 associated with clinicopathological factors in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous tissues, and the association between methylation level and clinicopathological features. The methylation level of the RASA3 in HCC samples was found significantly lower than that in the adjacent non-cancerous tissues (P
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hui Lin, Xiaoxiao Fan, LiFeng He, Daizhan Zhou Tags: Research Paper Source Type: research

Angiotensin-converting Enzyme Inhibitors Decrease the Incidence of Radiation-induced Pneumonitis Among Lung Cancer Patients: A Systematic Review and Meta-analysis
Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been demonstrated to mitigate radiation-induced lung damage in animal models and preclinical studies. Our study aims to evaluate whether ACEIs or ARBs reduce the incidence of radiation-induced pneumonitis (RP) in lung cancer patients.Methods: Publications were searched from EMBASE, PubMed and Web of Science databases. Seven studies published from April 2000 to August 2016 met inclusion criteria and included 1412 patients in total. Only patients with grade 2 and above pneumonitis within 12 months after radiotherapy wer...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Fengze Sun, Huanhuan Sun, Xiaobin Zheng, Guangwei Yang, Nana Gong, Huaili Zhou, Siyang Wang, Zhibin Cheng, Haiqing Ma Tags: Research Paper Source Type: research

Combined Use of the Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios as a Prognostic Predictor in Patients with Operable Soft Tissue Sarcoma
Conclusions: Preoperative CNP is associated with tumor progression and can be considered an independent marker of postoperative survival in patients with STS. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yao Liang, Wei Wang, Jingjing Li, Yuanxiang Guan, Yi Que, Wei Xiao, Xing Zhang, Zhiwei Zhou Tags: Research Paper Source Type: research

Current Smoking has a Detrimental Effect on Survival for Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) negative Advanced non-squamous Non-small Cell Lung Cancer (NSCLC) Patients Treated with Pemetrexed Continuation Maintenance
Conclusions: Current smoking is an independent negative predictive factor of outcomes for pemetrexed continuation maintenance therapy in advanced non-squamous NSCLC patients without EGFR mutations and ALK rearrangements. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Liping Lin, Juanjuan Zhao, Jiazhu Hu, Guorong Zou, Fuxi Huang, Jianjun Han, Yan He, Xiaolong Cao Tags: Research Paper Source Type: research

MicroRNA-30b targets Snail to impede epithelial-mesenchymal transition in pancreatic cancer stem cells
Snail-mediated epithelial-mesenchymal transition (EMT) process plays a fundamental role in facilitating pancreatic ductal adenocarcinoma (PDAC) stemness and metastasis. In the present study, we revealed that microRNA-30 (miR-30) members, especially miR-30b, were remarkably downregulated in triple-positive (CD24+, CD44+, EpCAM+) pancreatic cancer stem cells (PCSCs). In addition, we revealed that miR-30b suppressed EMT process in PCSCs. Overexpression of miR-30b led to reduced expression of mesenchymal marker N-cadherin and the upregulation of epithelial marker E-cadherin. Moreover, both of TargetScan and PicTar algorithms p...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yicheng Xiong, Yao Wang, Lei Wang, Yan Huang, Yang Xu, Liancheng Xu, Yibing Guo, Jingjing Lu, Xiaohong Li, Mingyan Zhu, Haixin Qian Tags: Research Paper Source Type: research

Long non-coding RNA CDKN2B antisense RNA 1 gene inhibits Gemcitabine sensitivity in bladder urothelial carcinoma
Conclusion: LncRNA CDKN2B-AS is high-expressed in BUC and related to low Gemcitabine sensitivity of BUC. CDKN2B-AS inhibited Gemcitabine sensitivity through Wnt signaling pathway in BUC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Dalong Xie, Hui Zhang, Chao Shang Tags: Research Paper Source Type: research

Does the Preoperative Prognostic Nutritional Index Predict Survival in Patients with Liver Metastases from Colorectal Cancer Who Underwent Curative Resection?
Conclusion: For patients with CRLM undergoing curative hepatic resection, preoperative PNI is a simple and efficient indicator (cut-off value=48.5) for preoperative estimation of oncologic outcomes. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yujie Zhao, Yuxiang Deng, Jianhong Peng, Qiaoqi Sui, Junzhong Lin, Miaozhen Qiu, Zhizhong Pan Tags: Research Paper Source Type: research

AMPH-1 is critical for breast cancer progression
Amphiphysin 1 (AMPH-1) is a nerve terminals-enriched protein involved in endocytosis, and we observe that its expression is increased in breast cancer tumor in compared with normal breast. However, its function in breast cancer is unknown. Here we aim to explore the role of AMPH-1 in breast cancer cells. Knockdown of AMPH-1 in breast cancer cells promotes cell proliferation, cell cycle progression and cell migration, and attenuates cell apoptosis. Of note, knockdown of AMPH-1 promotes breast cancer progression in xenograft mouse model. These oncogenic phenotypes may be partially due to the activated EMT and ERK pathways af...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yajun Chen, Jian Liu, Lei Li, Hefeng Xia, Zaijun Lin, Tianying Zhong Tags: Research Paper Source Type: research

Unique Responses of Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines toward Cantharidin and Norcantharidin
The present study aimed to investigate whether cell lines from human gastric and liver cancers respond differently toward cantharidin (CTD) and norcantharidin (NCTD) than other types of cancer cells. We first established the half maximal inhibitory concentrations (IC50s) of CTD for a large panel of cancer cell lines representing the 12 major types of human cancers and the mode of cell death induced by the two compounds. We next compared the growth inhibitory effects as well as the corresponding modes of action of CTD and NCTD. The IncuCyte ZOOM system was used as a semi-high throughput means to define IC50s and 90% inhibit...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qixiang Ma, Yanyan Feng, Kaiwen Deng, Haozhen Shao, Tongtong Sui, Xin Zhang, Xiao Sun, Lin Jin, Zhitao Ma, Guangbin Luo Tags: Research Paper Source Type: research

Technical Feasibility of Tissue Microarray (TMA) Analysis of Tumor-Associated Immune Response in Prostate Cancer
Introduction: The androgen receptor (AR) regulates immune-related epithelial-to-mesenchymal transition (EMT), and prostate cancer (PCa) metastasis. Primary tumor-infiltrating lymphocytes (TILs) [CD3+, CD4+, and CD8+ TILs] are potential prognostic indicators in PCa, and variations may contribute to racial disparities in tumor biology and PCa outcomes.Aim: To assess the technical feasibility of tumor microarray (TMA)-based methods to perform multi-marker TIL profiling in primary resected PCa.Methods: Paraffin-embedded tissue cores of histopathologically-confirmed primary PCa (n = 40; 1 TMA tissue specimen loss) were arrayed ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Timothy J. Wallace, Junqi Qian, Itzhak Avital, Curt Bay, Yan-Gao Man, Laurie L. Wellman, Chris Moskaluk, Dean Troyer, Dharam Ramnani, Alexander Stojadinovic Tags: Research Paper Source Type: research

Predicting hepatocellular carcinoma development for cirrhosis patients via methylation detection of heparocarcinogenesis-related genes.
The objective of this study was to elucidate risk factors to predict HCC development for cirrhosis patients.Methods: Multiple methylated specific PCR (MSP) was applied to determine methylation status of heparocarcinogenesis-related genes in 396 tissue and plasma specimens and multivariate cox model was used to analyze the relationship between risk variables and HCC development among cirrhosis patients, followed up in a median period of 30 months.Results: Among 105 LC cases, HCC incidence rate at 30 months was 30.48% (32/105), which were statistically associated with patients' age and aberrant methylation of p16, SFRP, and LINE1 (p
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yuan Huang, Ling Wei, Rong-Ce Zhao, Wei-Bo Liang, Jing Zhang, Xue-Qin Ding, Zhi-Long Li, Cheng-Jun Sun, Bo Li, Qiu-Ying Liu, Jing-Yang He, Xiao-Qin Yu, Bo Gao, Ming-Mei Chen, Ai-Min Sun, Yang Qin Tags: Research Paper Source Type: research

Multiple Myeloma Index for Risk of Infection
Based on our earlier research into the main characteristics and risk factors for infections in hospitalized patients with multiple myeloma, we created the numerical Multiple Myeloma Index for Risk of Infection (MMIRI) to predict infection in myeloma patients. The included factors that could influence the pathogenesis and incidence of infections were sex, performance status, Durie Salmon stage of disease, International Staging System, serum creatinine level, immune paresis, neutropenia, serum ferritin level, the presence of any catheters, disease duration, stable/progressive disease, and type of therapy. For each of these p...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Valkovic T, Gacic V, Nacinovic-Duletic A Tags: Short Research Communication Source Type: research

Salvage Carbon Ion Radiation Therapy for Locally Recurrent or Radiation-Induced Second Primary Sarcoma of the Head and Neck
Conclusions: With few observed acute and late toxicities, salvage CIRT can provide effective short-term tumor control. Further research, preferably in a prospective fashion, will be required to confirm the efficacy and safety of salvage CIRT in this patient population. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jing Yang, Jing Gao, Xiaodong Wu, Jiyi Hu, Weixu Hu, Lin Kong, Jiade J. Lu Tags: Research Paper Source Type: research

PD-L1 Expression On tumor Cells Was Associated With Unfavorable Prognosis In Esophageal Squamous Cell Carcinoma
Conclusions: PD-L1 expression was an independent risk factor for the prognosis of ESCC patients. Immunotherapy may achieve promising outcomes in ESCC patients with type I TIM. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qiao Wang, Fan Feng, Fei Wang, Zhen Liu, Shushang Liu, Guanghui Xu, Gaozan Zheng, Man Guo, Xiao Lian, Hongwei Zhang Tags: Research Paper Source Type: research

The Efficacy and Toxicity of Lobaplatin-contained Chemotherapy in Extensive-stage Small-cell Lung Cancer
To assess the efficacy and toxicity of Lobaplatin (LBP) -contained chemotherapy on extensive stage small-cell lung cancer (ES-SCLC), we conducted a prospective, single-arm, and multicenter Phase IV clinical trial on Lobaplatin (ChiCTR-ONC-13003471), and used the patient clinical data obtained from our cancer center to perform the analysis. Previously untreated patients with ES-SCLC were given LBP intravenously (IV) at 30 mg/m2 on day 1 and etoposide IV at 100 mg/m2 on day 1, 2, and 3. The treatment was cycled every 21 days, lasting for four to six cycles. The patients with second-line treatment or above were also included ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ning-ning Zhou, Yuan-yuan Zhao, Lin-zhu Zhai, Chao-mei Ruan, Yun-peng Yang, Yan Huang, Xue Hou, Li-kun Chen, Ting Zhou, Li Zhang Tags: Research Paper Source Type: research

Optimal biopsy strategy for prostate cancer detection by performing a Bayesian network meta-analysis of randomized controlled trials
Conclusion: Taken together, in a comprehensive consideration of four clinical outcomes, our outcomes shed light on that FUS-GB or FUS-GB plus TRUS-GB showed their superiority, compared with other puncture methods in the detection of PCa. Moreover, TPUS or TRUS-GB was more easily associated with the over-diagnosis and over-treatment of PCa. In addition, targeted biopsy was obviously more effective than traditional random biopsy. The subsequent RCTs with larger sample sizes were required to validate our findings. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yi Wang, Jundong Zhu, Zhiqiang Qin, Yamin Wang, Chen Chen, Yichun Wang, Xiang Zhou, Qijie Zhang, Xianghu Meng, Ninghong Song Tags: Research Paper Source Type: research

Gene Expression Detection Assay for Cancer Clinical Use
Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treatment prediction in a clinical setting. In this review, we investigated six gene expression assay systems (qRT-PCR, DNA microarray, nCounter, RNA-Seq, FISH, and tissue microarray) that are currently being used in clinical cancer studies. Some of these methods are also commonly used in a modified way; for exampl...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shavira Narrandes, Wayne Xu Tags: Review Source Type: research

Zusanli (ST36) Acupoint Injection with Neostigmine for Paralytic Postoperative Ileus following Radical Gastrectomy for Gastric Cancer: a Randomized Clinical Trial
Background: The Zusanli (ST36) acupoint has been associated with treatment of various gastrointestinal conditions. There have been no studies of acupuncture therapy for paralytic postoperative ileus (PPOI).Materials and methods: Patients with PPOI following gastrectomy for gastric cancer were randomized to receive ST36 acupoint injection with neostigmine, gluteal intramuscular injection with 1.0 mg neostigmine, ST36 acupuncture alone, or standard therapy. The main outcome was the effectiveness rate for recovery of peristalsis. Secondary outcomes were time to bowel sound recovery, time to first flatus, and time to first def...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiaolan You, Yuanjie Wang, Jian Wu, Qinghong Liu, Yanqing Liu, Yayun Qian, Jue Chen, Dong Tang, Daorong Wang Tags: Research Paper Source Type: research

Aberrant methylation of FAT4 and SOX11 in peripheral blood leukocytes and their association with gastric cancer risk
Conclusions: FAT4 aberrant methylation in peripheral blood leukocytes and gene-environment interactions were associated with the risk of GC, while SOX11 was controversial and needed to be more investigated. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hongxu Sun, Haibo Zhou, Yan Zhang, Jie Chen, Xu Han, Di Huang, Xiyun Ren, Yunhe Jia, Qing Fan, Wenjing Tian, Yashuang Zhao Tags: Research Paper Source Type: research

Risk Stratification of Upper Urinary Tract Urothelial Carcinoma Patients for Survival Prediction: A Simple Summation Scoring Method
Purpose: To stratify upper urinary tract urothelial carcinoma (UTUC) patients into risk groups in terms of 5-year survival.Methods and materials: All potential UTUC patients recorded in our cancer registry database from 1997 to 2011 were evaluated for authentic presence of UTUC. Age at diagnosis, sex, organ involvement, dialysis, renal transplantation status, clinical stage, survival to the last follow-up, and the cause of death of each patient were recorded. All patients were randomized into a developmental set or a validation set at a 1:1 ratio. Survival prediction models and scores were developed using the developmental...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Li-Jen Wang, Wen-Chi Chou, See-Tong Pang, Chih-Wei Yang, Cheng-Keng Chuang, Ying-Hsu Chang, Ming-Li Hsieh, Yon-Cheong Wong Tags: Research Paper Source Type: research

The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma
Conclusions: COR-BMI may serve as an indicator of poor prognosis in both NPC and metastatic NPC. Radiotherapy plus chemotherapy may benefit patients with a COR-BMI score of 1. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yan Wang, Sha-Sha He, Xiu-yu Cai, Hai-Yang Chen, Xing-Li Yang, Li-Xia Lu, Yong Chen Tags: Research Paper Source Type: research

The Tumor Mutational Burden of Chinese Advanced Cancer Patients Estimated by a 381-cancer-gene Panel
Purpose: Tumor mutational burden (TMB) calculated by whole-exome sequencing (WES) is proved to be effective to predict the clinical benefit of immune checkpoint blockades. However, WES is not commonly used in China. We aimed to determine if a 381-caner-gene panel (CGP) could be used to estimate TMB, delineate the landscape of TMB of Chinese patients and identify mutated genes and pathways related to higher TMB.Methods: We first evaluated the correlation between the TMB estimated by a 381-cancer-gene panel MasterView and WES using the data from the melanoma sample cohort. 3023 formalin fixed, paraffin-embedded tumor specime...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wu Zhuang, Junxun Ma, Xudong Chen, Guoqiang Wang, Jing Lu, Yanan Chen, Hua Dong, Shangli Cai, Yuzi Zhang, Xiaochen Zhao, Youcai Zhu, Chunwei Xu, Yunjian Huang, Zhangzhou Huang, Xiaofeng Zhu, Hong Jiang, Zhijie Wang Tags: Research Paper Source Type: research

Stromal Infiltration of Tumor-Associated Macrophages Conferring Poor Prognosis of Patients with Basal-Like Breast Carcinoma
Conclusions: Our results highlight the prognostic importance of TAMs' location in BLBC. CD163, a highly specific biomarker for M2 macrophages, is an independent prognostic marker for BLBC patients, and may serve as an indicator or potential target of macrophage-centred therapeutic strategies. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Mu Yang, Zhenhua Li, Meijing Ren, Shuai Li, Lanjing Zhang, Xinmin Zhang, Fangfang Liu Tags: Research Paper Source Type: research

MicroRNA-1296 Facilitates Proliferation, Migration And Invasion Of Colorectal Cancer Cells By Targeting SFPQ
MicroRNAs (miRNAs) are involved in cancer genesis and progression via acting as tumor suppressors or oncogenes. Previous studies report that miR-1296 shows upregulation in both colorectal cancer (CRC) tissues and plasma samples. However, the accurate clinical significance of miR-1296 and its role in CRC have not been well investigated. The aim of the present study was to disclose the aberrant expression, clinical significance, and the relevant biological function of miR-1296 in CRC. We found a marked upregulation of miR-1296 expression in CRC tissues compared to tumor-adjacent tissues. MiR-1296 overexpression was detected ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Youmao Tao, Chong Ma, Qihao Fan, Yannan Wang, Tao Han, Caixia Sun Tags: Research Paper Source Type: research

A decision tree-based prediction model for fluorescence in situ hybridization HER2 gene status in HER2 immunohistochemistry-2+ breast cancers: a 2538-case multicenter study on consecutive surgical specimens
Objective: To investigate the proportion of HER2 gene amplifications and the association between the HER2-IHC-staining pattern and gene status in IHC-2+ breast cancers according to 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines.Methods: We retrospectively analyzed and re-evaluated the IHC-staining pattern of 2538 IHC-2+ surgical specimens of breast cancer from November 2014 to October 2015 in 12 institutions. All cases used for building a prediction model of HER2 gene amplification according to the IHC-staining pattern and were randomly divided into a training set (n = 1...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Libo Yang, Zhang Zhang, Jiayuan Li, Min Chen, Jieliang Yang, Jing Fu, Hong Bu, Shaoxian Tang, Yueping Liu, Huixiang Li, Xiaomei Li, Fangping Xu, Xiaodong Teng, Yinghong Yang, Yun Ma, Shuangping Guo, Jinfen Wang, Deyu Guo Tags: Research Paper Source Type: research

Enhancer RNAs (eRNAs): New Insights into Gene Transcription and Disease Treatment
Enhancers are cis-acting elements that have the ability to increase the expression of target genes. Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity enhancers and are involved in the regulation of gene transcription. The in-depth study of eRNAs is of great significance for us to better understand enhancer function and transcriptional regulation in various diseases. Therefore, eRNAs may be a potential therapeutic target for diseases. Here, we review the current knowledge of the characteristics of eRNAs, the molecular mechan...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Mengting Ding, Yuhan Liu, Xinhui Liao, Hengji Zhan, Yuchen Liu, Weiren Huang Tags: Review Source Type: research

Prognostic Value of Albumin/Globulin Ratio in Survival and Lymph Node Metastasis in Patients with Cancer: A Systematic Review and Meta-analysis
The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search through six electronic databases has been carried out to identify reports involving the role of AGR on OS and LNM in human cancers. Hazard ratio (HR), odd ratio (OR) and their 95% confidence intervals (95% CI) were evaluated through meta-analysis according to standard steps. Of 403 studies retrieved, 14 eligible st...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jieshan Chi, Qizhi Xie, Jingjing Jia, Xiaoma Liu, Jingjing Sun, Junhui Chen, Li Yi Tags: Review Source Type: research

Synaptotagmin7 Is Overexpressed In Colorectal Cancer And Regulates Colorectal Cancer Cell Proliferation
Conclusions: Our study suggests that SYT7 plays an important role in the development of CRC and SYT7 may become a new therapeutic target in CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Kewei Wang, Huimin Xiao, Jiaqi Zhang, Dehua Zhu Tags: Research Paper Source Type: research

Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma
Conclusion: Our study indicated that MCM2-7 genes may be potential diagnostic biomarkers in patients with HCC. Among them, MCM2 and MCM6 may serve as potential prognostic biomarkers for HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiwen Liao, Xiaoguang Liu, Chengkun Yang, Xiangkun Wang, Tingdong Yu, Chuangye Han, Ketuan Huang, Guangzhi Zhu, Hao Su, Wei Qin, Rui Huang, Long Yu, Jianlong Deng, Xianmin Zeng, Xinping Ye, Tao Peng Tags: Research Paper Source Type: research

NOTCH4 Is a Novel Prognostic Marker that Correlates with Colorectal Cancer Progression and Prognosis
Notch family plays vital role in carcinogenesis and progression of various cancer, however, its clinical significance and prognostic value in colorectal cancer isn't fully investigated. In present study, we first investigated the NOTCH4 expression in The Cancer Genome Atlas (TCGA) (n=361) and GSE39582 (n=474) database and then validated with our own database (n=248). The transcriptional and protein levels of NOTCH4 were evaluated by RT-PCR and immunohistochemistry study, respectively. Univariate and multivariate survival analyses were performed to explore the relationship between various prognostic factors and survival out...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Guiyang Wu, Zaiping Chen, Jing Li, Fubo Ye, Guoping Chen, Qinghao Fan, Hao Dong, Shichao Yuan, Xiongwen Zhu Tags: Research Paper Source Type: research

Modified CLIP score with the albumin-bilirubin grade retains prognostic value in HBV-related hepatocellular carcinoma patients treated with trans-catheter arterial chemoembolization therapy
Conclusions: In conclusion, our present study suggested that the ALBI-CLIP scoring system retained the prognostic value of the CLIP in HBV-related HCC treated with TACE therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiu-Rong Cai, Zhan-Hong Chen, Meng-Meng Liu, Jin-Xiang Lin, Xiao-Ping Zhang, Jie Chen, Qu Lin, Xiao-Kun Ma, Jing-Yun Wen, Si-Dong Xie, Xiang-Yuan Wu, Min Dong Tags: Research Paper Source Type: research

PDE4a predicts poor prognosis and promotes metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
Phosphodiesterases (PDEs) was found to be involved in a variety of cancer pathologies by modulating the degradation of levels of cAMP/cGMP. However, the prognostic significance and biological effect of PDE4a in hepatocellular carcinoma (HCC) have not been understood completely. In the present study, PDE4a expression was detected in a cohort of HCC and matched adjacent liver tissues (n = 210) by immunohistochemistry staining and Western immunoblotting assay, And in vitro experiments were conducted to determine the effect of PDE4a on metastatic capacity of HCC cells. The data here displayed that the majority of HCC patients ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yanghong Peng, Yijun Li, Yu Tian, Guokun Ao Tags: Research Paper Source Type: research

Prognostic Values of CCNE1 Amplification and Overexpression in Cancer Patients: A Systematic Review and Meta-analysis
A number of studies revealed that CCNE1 copy number amplification and overexpression (on mRNA or protein expression level) were associated with prognosis of diverse cancers, however, the results were inconsistent among studies. So we conducted this systematic review and meta-analysis to investigate the prognostic values of CCNE1 amplification and overexpression in cancer patients. PubMed, Cochrane library, Embase, CNKI and WanFang database (last update by February 15, 2018) were searched for literatures. A total of 20 studies were included and 5 survival assessment parameters were measured in this study, which included ove...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Haiyue Zhao, Junling Wang, Yong Zhang, Ming Yuan, Shuangxiang Yang, Lisong Li, Huilin Yang Tags: Research Paper Source Type: research

Comparison of vascularity observed using contrast-enhanced 3D ultrasonography and pathological changes in patients with hepatocellular carcinoma after sorafenib treatment
Aim: The aim of this study was to compare vascularity observed using contrast-enhanced 3D ultrasonography and pathological changes in human hepatocellular carcinoma (HCC) and surrounding non-tumorous areas after sorafenib treatment.Materials and methods: Twelve patients with HCC were enrolled in this clinical study. The maximum tumor diameter as measured using sonography ranged from 15 to 33 mm (mean, 24.0 mm; SD, 5.7 mm). Assessments using contrast-enhanced (0.2 mL of Sonazoid suspension; Daiichi Sankyo, Tokyo, Japan) 3D ultrasonography (LOGIQ 7; GE Healthcare, Milwaukee) were performed in all the patients before and 1 we...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hiroyuki Fukuda, Kazushi Numata, Koji Hara, Akito Nozaki, Masaaki Kondo, Makoto Chuma, Masayuki Nakano, Akinori Nozawa, Shin Maeda, Katsuaki Tanaka Tags: Research Paper Source Type: research

ELTD1 Function in Hepatocellular Carcinoma is Carcinoma-Associated Fibroblast-Dependent
Conclusion: The results of this study indicated that ELTD1 regulation of HCC progression is CAF-dependent, suggesting that ELTD1 function is regulated by its tumor microenvironment. Further investigation is required to determine the underlying mechanisms. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Anna Kan, Yong Le, Yong-fa Zhang, Fang-ting Duan, Xiao-ping Zhong, Liang-he Lu, Yi-hong Ling, Rong-ping Guo Tags: Research Paper Source Type: research

Additional lymphadenectomy might not improve survival of patients with resectable metastatic colorectal adenocarcinoma of T4 stage, proximal location, poor/undifferentiation, or N3/N4 stages: a large population-based study.
This study was performed to evaluate the prognostic effect of lymphadenectomy on outcomes in patients with resectable metastatic colorectal adenocarcinoma (mCRC). We selected patients with mCRC from 2004 to 2013 from Surveillance, Epidemiology, and End Results Program (SEER) database. Kaplan-Meier analysis, univariate Cox regression and multivariate Cox regression analysis were performed to assess the clinical value of lymphadenectomy on overall survival (OS) and cause-specific survival (CSS) of patients with resectable mCRC. A total 24178 eligible patients were included, 23056 (95.36%) of which received lymphadenectomy. R...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yang-Yang Zhou, Qing-Wei Zhang, Jian Huang, Xia-Lin Yan, Chao Chen, Fan-Fan Xu, Xiao-Jing Du, Rong Jin Tags: Research Paper Source Type: research

LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer
In this study, we observed an increased proportion of MDSCs and elevated levels of the related molecule arginase-1 (ARG-1) in peripheral blood mononuclear cells (PBMCs) obtained from lung cancer patients. The proportion of CD8+ cytotoxic T lymphocyte (CTL) was significantly decreased in PBMCs from lung cancer patients. Moreover, the proportion of CTL cells was negatively correlated with the proportion of MDSCs. Furthermore, MALAT1 levels were decreased in PBMCs from lung cancer patients. The relative expression of MALAT1 was moderate negatively correlated with the proportion of MDSCs. In vitro results indicate that the kno...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qinfeng Zhou, Xinyi Tang, Xinyu Tian, Jie Tian, Yue Zhang, Jie Ma, Huaxi Xu, Shengjun Wang Tags: Research Paper Source Type: research

Dosimetric Effects of Head and Neck Immobilization Devices on Multi-field Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma
Conclusion: The attenuation and bolus effects of the head and neck immobilization device reduce dose coverage rate and average dose of the planning target volumes in nasopharyngeal carcinoma and lead to an increase in the skin dose. During treatment planning and dose calculation, the immobilization device should be included within body contour to account for the dose attenuation and skin dose increment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Li Chen, Ying-Lin Peng, Shi-Yong Gu, Hui Shen, Dan-Dan Zhang, Wen-Zhao Sun, Jian-Hua Wu, Xiao-Wu Deng Tags: Research Paper Source Type: research