Yangyin Fuzheng Decoction enhances anti-tumor efficacy of cisplatin on lung cancer
This study aimed to investigate anti-tumor activity and the underlying mechanisms of Yangyin Fuzheng Decoction combined with cisplatin in the treatment of lung cancer. We established lung cancer model in C57BL/6 mice injected with mouse Lewis lung cancer cells. Our results demonstrated that Yangyin Fuzheng Decoction treatment increased necrotic area in tumor tissue, and significantly enhanced the recruitment of inflammatory cells into the tumor. In addition, Yangyin Fuzheng Decoction treatment enhanced the anti-tumor efficacy of cisplatin and partially recovered mouse body weight loss caused by cisplatin treatment. Mechani...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Dongmei Wei, Lin Wang, Yuhan Chen, Gang Yin, Mei Jiang, Rui Liu, Hong Chen, Xiyuan Sun Tags: Research Paper Source Type: research

Capable Infection of Hepatitis B Virus in Diffuse Large B-cell Lymphoma
This study tested the hypothesis that hepatitis B virus (HBV) infection is also associated with DLBCL.Methods: Clinical analysis of the correlation between DLBCL and HBV infection, detection of HBV in situ of DLBCL tissue, and biological experiments that determined whether HBV infects B lymphocytes were conducted.Results: Our long-term clinical data showed that the positive rate of serum HBV was significantly increased in DLBCL patients (23.6%) compared to that in the general Chinese population (7.2%, P
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yanchun Wang, Huijie Wang, Shaokun Pan, Tao Hu, Jiabin Shen, Hui Zheng, Suhong Xie, Youhua Xie, Renquan Lu, Lin Guo Tags: Research Paper Source Type: research

B cell lymphoma with different metabolic characteristics show distinct sensitivities to metabolic inhibitors
Conclusions: The cells rely more on glucose/gltamine have a stronger sensitivity to glucose/glutamine depletion or glycolysis/ glutaminolysis inhibition and a lessened sensitivity to glutaminolysis/glycolysis inhibitors. To target tumor metabolism based on metabolic characteristics may provide a new therapeutic strategy for the treatment of B cell lymphoma. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiaoxia Liu, Li Wang, Weiye Jiang, Wenhua Lu, Jing Yang, Wenbiao Yang Tags: Research Paper Source Type: research

LMO1 super-enhancer polymorphism rs2168101 G > T correlates with decreased neuroblastoma risk in Chinese children
Neuroblastoma is one of the most frequently occurring childhood cancers. The rs2168101 G>T polymorphism observed in the LMO1 gene is located at a conserved GATA transcription factor binding motif. This polymorphism was reported to be significantly associated with neuroblastoma susceptibility. However, whether this and other functional polymorphisms can affect neuroblastoma risk of Chinese children remains unknown. We conducted a two-center hospital-based case-control study with a total of 374 cases and 812 controls to assess the role of five LMO1 gene polymorphisms in the neuroblastoma risk. We confirmed that rs2168101 ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jing He, Xiaohong Zhang, Jiao Zhang, Ruizhong Zhang, Tianyou Yang, Jinhong Zhu, Huimin Xia, Yan Zou Tags: Research Paper Source Type: research

A Multicenter Retrospective Comparison of Sequential versus Sandwich Chemoradiotherapy for Stage IE-IIE Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type
Conclusions: In the era of L-asparaginase/pegaspargase, both sequential and sandwich chemoradiotherapy are safe and similarly effective in patients with newly diagnosed stage IE-IIE ENKTL. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jin Li, Yajun Li, Meizuo Zhong, Wei Liu, Xianling Liu, Jiwei Li, Kunlun Li, Pingyong Yi Tags: Research Paper Source Type: research

Hepatotoxicity in Advanced Lung Adenocarcinoma: A Retrospective Study of 2108 Cases
The study aimed to identify the risk factors and frequency of hepatotoxicity in patients with advanced lung adenocarcinoma. Liver function tests were documented in 2108 patients with advanced (IIIB/IV) lung adenocarcinoma at a single institution who received first line platinum-based doublet chemotherapy. Hepatotoxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. Risk factors for hepatotoxicity were assessed using logistic regression analysis. Differences in hepatotoxicity between pemetrexed and non-pemetrexed regimens were evaluated after propensity score matching. Afte...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jie Qian, Xueyan Zhang, Bo Zhang, Ping Gu, Lin Wang, Baohui Han Tags: Research Paper Source Type: research

Risk of immune-related colitis with PD-1/PD-L1 inhibitors vs chemotherapy in solid tumors: systems assessment
Conclusions: Our meta-analysis demonstrates that compared with chemotherapy, pembrolizumab may result in a higher risk of all-grade immune-mediated colitis. PD-1/PD-L1 inhibitor treatment in NSCLC patients, but not in melanoma patients, increases the risk of all-grade colitis incidence. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qiang Su, Xiaochen Zhang, Xinhua Shen, Yanli Hou, Zhigang Sun, Zu Hua Gao Tags: Research Paper Source Type: research

Diagnostic and prognostic value of microRNA-628 for cancers
Conclusions: This study confirms that miR-628 may be a promising biomarker for cancer diagnosis and prognosis. Expertly, microRNAs combination biomarkers could be a new alternative for clinical application. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jing-Hua Li, Shan-Shan Sun, Chang-Jin Fu, An-Qi Zhang, Chen Wang, Rong Xu, Shu-Yang Xie, Ping-Yu Wang Tags: Research Paper Source Type: research

The Efficacy and Late Toxicities of Computed Tomography-based Brachytherapy with Intracavitary and Interstitial Technique in Advanced Cervical Cancer
Purpose: To report the efficacy and late side effects(LSEs) of CT-based image-guided brachytherapy for the treatment of cervical cancer.Materials: Between 2008 and 2014, 100 patients with FIGO stage IIB-IVA cervical carcinoma were analyzed. The patients received pelvic irradiation (45-50 Gy in 25 fractions) with concurrent chemotherapy, whereas the mean prescribed EBRT dose, including initial and boost doses to positive lymph nodes, ranged from 54 to 64 Gy. Afterwards, intracavitary(IC) or combined intracavitary/interstitial(IC/IS) brachytherapy was performed using a CT-based procedure with prescribed doses of 6 or 8 Gy in...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yun-Zhi Dang, Pei Li, Jian-Ping Li, Fei Bai, Ying Zhang, Yun-Feng Mu, Wei-Wei Li, Li-Chun Wei, Mei Shi Tags: Research Paper Source Type: research

Effectiveness of Cetuximab in Combination with Concurrent Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma: A 1:2 Propensity Score-matched Analysis
Conclusions: This study reveals that patients with locoregionally advanced NPC could benefit from the addition of cetuximab to CCRT, and this therapeutic gain mainly originated from T4 and/or N3 subgroup although suffering more acute moderate to severe toxicities. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Li-Rong Wu, Huan-feng Zhu, Jianhua Xu, Xue-song Jiang, Li Yin, Ning Jiang, Dan Zong, Fei-jiang Wang, Sheng-fu Huang, Xiu-hua Bian, Jian-feng Wu, Dan Song, Wen-jie Guo, Ju-Ying Liu, Xia He Tags: Research Paper Source Type: research

Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
The initiation and progression of colorectal cancer (CRC) involves genetic and epigenetic alterations influenced by dietary and environmental factors. Increasing evidence has linked the intestinal microbiota and colorectal cancer. More recently, Fusobacterium nucleatum (Fn), an opportunistic commensal anaerobe in the oral cavity, has been associated with CRC. Several research teams have reported an overabundance of Fn in human CRC and have elucidated the possible mechanisms by which Fn is involved in colorectal carcinogenesis in vitro and in mouse models. However, the mechanisms by which Fn promotes colorectal carcinogenes...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Sheng Zhang, Sanjun Cai, Yanlei Ma Tags: Review Source Type: research

Preoperative SCC-Ag and thrombocytosis as predictive markers for pelvic lymphatic metastasis of squamous cervical cancer in early FIGO stage
Conclusions: Preoperative SCC-Ag alone or combined with thrombocytosis might be used as predictive markers for PLM before initial treatment in early stage SCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Fan Xu, Yanfang Li, Liangsheng Fan, Jing Ma, Lan Yu, Hongyan Yi, Xiaojing Chen, Wenfei Wei, Peng Wu, Li Liang, Huiquan Hu, Hui Xing, Wei Wang Tags: Research Paper Source Type: research

Surgical management of periampullary adenocarcinoma: defining an optimal prognostic lymph node stratification schema
Conclusion: LODDS performs better than other LN staging systems in predicting OS and PFS for patients with periampullary adenocarcinoma after surgical resection. Adequate LN dissection is necessary for curative surgery, as well as to achieve a more accurate staging of the disease and a more precise prediction of survival for these patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chaobin He, Yize Mao, Jun Wang, Xin Huang, Xiaojun Lin, Shengping Li Tags: Research Paper Source Type: research

Quality Control of Next-generation Sequencing-based In vitro Diagnostic Test for Onco-relevant Mutations Using Multiplex Reference Materials in Plasma
Conclusions: The results indicated our reference materials would be pivotal for quality control of NGS-based cancer IVDs and would guide the further development of reference materials covering more onco-relevant mutations. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Donglai Liu, Haiwei Zhou, Dawei Shi, Shu Shen, Yabin Tian, Lin Wang, Jiatao Lou, Rong Cong, Juan Lu, Henghui Zhang, Meiru Zhao, Shida Zhu, Zhisheng Cao, Ruilin Jin, Yin Wang, Xiaoni Zhang, Guohua Yang, Youchun Wang, Chuntao Zhang Tags: Research Paper Source Type: research

PIASy antagonizes Ras-driven NSCLC survival by promoting GATA2 SUMOylation
In this study, we found a decreased expression of PIASy in RAS mutant NSCLC cell lines and specimens with RAS mutations. Forced expression of PIASy in NSCLC cells inhibits their viability in vitro, as well as tumorigenesis and growth in vivo. Mechanistically, we demonstrated overexpression of PIASy in A549 cells altered the regulated transcriptional network of GATA2, including proteasome, IL-1-signaling, and Rho-signaling pathways. Forced expression of PIASy resulted in the accumulated SUMOylation of GATA2, attenuating its transcriptional activity in A549 cells. These results collectively suggest that PIASy plays an antago...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Bin Chen, Jie Luo, Yirui Zhou, Xu Xin, Rong Cai, Chunhua Ling Tags: Research Paper Source Type: research

The latest exploration of staging and prognostic classification for pancreatic neuroendocrine tumors: a large population-based study
Conclusions: The rENETS staging system has superior distribution in proportion than the AJCC 7th, ENETS or mENETS staging system, and one more accurate and advanced predictive model will be achieved via the incorporation to be adopted in clinical practice. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shanshan Gao, Ning Pu, Lingxiao Liu, Changyu Li, Xuefeng Xu, Xiaolin Wang, Wenhui Lou Tags: Research Paper Source Type: research

Hypothesis: Cancer Is a Disease of Evolved Trade-Offs Between Neoplastic Virulence and Transmission
Virulence is defined as the ability of a pathogen to cause morbidity and/or mortality in infected hosts. The relationship between virulence and transmissibility is complex; natural selection may promote decreased virulence to enhance host mobility and increase the probability for transmission, or transmissibility may be enhanced by increased virulence, leading to higher pathogen load and, in some cases, superior evasion from host defenses. An evolutionary trade-off exists between the ability of pathogens to maintain opportunities for long-term transmission via suppressed virulence and increased short-term transmission via ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Michael Bordonaro Tags: Review Source Type: research

The clinical impact of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: Analyses of pooled data from two phase II randomized clinical trials (HANGESHA-G and HANGESHA-C)
Background: The current pooled analysis evaluated the efficacy of Hangeshashinto (TJ-14) in the prevention and/or treatment of chemotherapy-induced oral mucositis (COM) in gastric cancer and colorectal cancer using two prospective, multi-institutional, randomized, double-blind, placebo-controlled phase II trials.Patients and Methods: HANGESHA-G and HANGESHA-C randomly assigned patients with gastric cancer or colorectal cancer who developed moderate to severe COM (grade ≥1) during any cycle of chemotherapy to receive either TJ-14 or a placebo as a double-blind trial. The patients received a placebo or TJ-14 for four to s...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Kazuhiro Nishikawa, Toru Aoyama, Mari S Oba, Takaki Yoshikawa, Chu Matsuda, Yoshinori Munemoto, Nobuhiro Takiguchi, Kazuaki Tanabe, Naoki Nagata, Motohiro Imano, Mitsuru Oshiro, Ryoji Fukushima, Masato Kataoka, Satoshi Morita, Akira Tsuburaya, Hideyuki Mi Tags: Research Paper Source Type: research

Monitoring changes in quality of life in patients with lung cancer under treatment with chemotherapy and co administration of zoledronic acid by using specialized questionnaires
Background: Due to the severity of the primary disease in patients with lung cancer, quality of life (QoL) is often overlooked. Factors that form QoL should be taken in consideration when planning the appropriate treatment and determining therapy targets, because of the increasing frequency of bone metastasis leading to high levels of pain. Purpose of this study is to assess quality of life in patients with lung cancer, before and after treatment combined with zoledronic acid.Methods and materials: QoL was assessed in 80 patients (49 males-31 females), of which 45 developed bone metastasis. Prior and post treatment (with c...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ioannis Tremmas, George Petsatodis, Michael Potoupnis, Stella Laskou, Dimitrios Giannakidis, Stylianos Mantalovas, Charilaos Koulouris, Athanasios Katsaounis, Efstathios Pavlidis, Aikaterini Amaniti, Haidong Huang, Chong Bai, Dongchen Shi, Athanasios Dard Tags: Research Paper Source Type: research

A predicting model of bone marrow malignant infiltration in 18F-FDG PET/CT images with increased diffuse bone marrow FDG uptake
Conclusion: Increased diffuse BM 18F-FDG uptake can be attributed to both bone marrow MI and benign etiologies. A decision tree based on C5.0 algorithm, combining PET/CT imaging and clinical features, is of potential use in discriminating BM malignant infiltration from patients with increased diffuse BM uptake. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Mingge Zhou, Yumei Chen, Jianjun Liu, Gang Huang Tags: Research Paper Source Type: research

Sorafenib Monotherapy Versus Sorafenib Combined with Regional Therapies for Hepatocellular Carcinoma Patients with Pulmonary Oligometastases: A Propensity Score-matched Analysis
Conclusions: Sorafenib combined with regional therapies may be associated with prolonged OS and TTP in HCC patients with pulmonary oligometastases compared with sorafenib monotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jinbin Chen, Shixun Lu, Yaojun Zhang, Li Xu, Jiancong Chen, Juncheng Wang, Minshan Chen, Rongxin Zhang, Zhongguo Zhou Tags: Research Paper Source Type: research

Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer
Conclusion: We draw comprehensive profiles of alternative splicing events in the carcinogenesis and prognosis of CRC. The interaction network and functional connections were constructed to elucidate the underlying mechanisms of alternative splicing in CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jingwei Liu, Hao Li, Shixuan Shen, Liping Sun, Yuan Yuan, Chengzhong Xing Tags: Research Paper Source Type: research

The prognosis of neck residue nasopharyngeal carcinoma (NPC) patients: results from a case-cohort study
Background: To assess the prognosis of neck residue nasopharyngeal carcinoma (NPC) patients and the efficacy of neck dissection in the treatment of these patients.Methods: We recruited 68 neck residue NPC patients. For each neck residue patient we had three matched NPC patients without neck residue as controls (n = 204). The primary endpoint was progression-free survival (PFS). The Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs), and multivariable analysis was used to test the independent statistical significance of NPC patients.Results: Compared to controls, the...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Sai-Lan Liu, Lin-Quan Tang, Qiu-Yan Chen, Huan-Xin Lin, Qi Yang, Qian Zhu, Wen Wen, Shan-Shan Guo, Li-Ting Liu, Yang Li, Hao-Jun Xie, Qing-Nan Tang, Xue-Song Sun, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Chao Lin, Xiao-Wen Lan, Hai-Qiang Mai, Ling Guo Tags: Research Paper Source Type: research

Current status and future directions of cancer immunotherapy
In the past decades, our knowledge about the relationship between cancer and the immune system has increased considerably. Recent years' success of cancer immunotherapy including monoclonal antibodies (mAbs), cancer vaccines, adoptive cancer therapy and the immune checkpoint therapy has revolutionized traditional cancer treatment. However, challenges still exist in this field. Personalized combination therapies via new techniques will be the next promising strategies for the future cancer treatment direction. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hongming Zhang, Jibei Chen Tags: Review Source Type: research

Oncoplastic breast reconstruction with omental flap: A retrospective study and systematic review
The increasing frequency of early breast cancer cases has driven an increasing number of patients to choose immediate reconstruction with an autologous flap. Omentum-flap-based breast reconstruction is a unique strategy that is highly suitable for repairing moderate tissue defects. However, all available evidence comes from individual reports with small numbers of cases, and the overall effectiveness and safety of the procedure have yet to be reported. Here, we reported 7 cases of laparoscopically harvested omental free flap breast reconstruction and performed a systematic review to assess the applicability and safety of t...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chao Ni, Ziguan Zhu, Yin Xin, Qingping Xie, Hongjun Yuan, Miaochun Zhong, Wenjie Xia, Xiaoyan Zhu, Zhengye Lv, Xiangyang Song Tags: Research Paper Source Type: research

The impact of microsatellite instability status and sidedness of the primary tumor on the effect of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer
Conclusions: The effect of bevacizumab was not different between LC and RC and between MSS and the MSI-H tumors. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Seung Tae Kim, Hee Kyung Kim, Jeeyun Lee, Se Hoon Park, Ho Yeong Lim, Young Suk Park, Won Ki Kang, Joon Oh Park Tags: Research Paper Source Type: research

Trends in Treatment for Prostate Cancer in China: Preliminary Patterns of Care Study in a Single Institution
Objectives: A Patterns of Care Study (PCS) was performed in the largest regional medical center in Zhejiang Province, China. The hospital information system (HIS) was used to evaluate patient characteristics and changes in initial treatment patterns for prostate cancer and to determine recent predominant trends in treatment plans for prostate cancer (PCa) in China.Methods: Men who were newly diagnosed with localized or locally advanced PCa for 2010-2011 and 2016-2017 were identified in the HIS database. Patient characteristics and temporal trends in initial management were assessed, and differences between groups were eval...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Feng Zhao, Jiayan Shen, Zuguo Yuan, Xiaokai Yu, Peng Jiang, Baishu Zhong, Jianjian Xiang, Guoping Ren, Liping Xie, Senxiang Yan Tags: Research Paper Source Type: research

Differential diagnostic roles of the serum CA19-9, total bilirubin (TBIL) and the ratio of CA19-9 to TBIL for benign and malignant
This study compared the differences and the differential diagnostic roles of the increase-folds of the serum CA19-9, TBIL and the ratio of increase-folds of CA19-9 to increase-folds of TBIL in 508 cases of malignant (MOJ) and benign (BOJ) obstructive jaundice patients.Methods: Totally, 508 cases of obstructive jaundice patients with pathological results were retrospectively enrolled. 342 cases were MOJ, including gallbladder adenocarcinoma, extrahepatic cholangiocarcinoma, periampullar adenocarcinoma and pancreatic adenocarcinoma.The other 166 cases were BOJ, including cholelithiasis, primary sclerosing cholangitis (PSC), ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wei Liu, Qiaofei Liu, Wenqin Wang, Penghui Wang, Jieming Chen, Tao Hong, Ning Zhang, Binglu Li, Qiang Qu, Xiaodong He Tags: Research Paper Source Type: research

Tumor PD-L1 Expression and Clinical Outcomes in Advanced-stage Non-Small Cell Lung Cancer Patients Treated with Nivolumab or Pembrolizumab: Real-World Data in Taiwan
Conclusion: The efficacy and safety of anti-PD-1 medications for advanced NSCLC were comparable in real-world and clinical settings, except in those with poor ECOG scores. Prediction of treatment response from tumor PD-L1 expression seemed practical. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shu-Yung Lin, Ching-Yao Yang, Bin-Chi Liao, Chao-Chi Ho, Wei-Yu Liao, Kuan-Yu Chen, Tzu-Hsiu Tsai, Chia-Lin Hsu, Wei-Hsun Hsu, Kang-Yi Su, Yih-Leong Chang, Jih-Hsiang Lee, Chia-Chi Lin, Jin-Yuan Shih, James Chih-Hsin Yang, Chong-Jen Yu Tags: Research Paper Source Type: research

P21-activated kinase 7 (PAK7) interacts with and activates Wnt/ β -catenin signaling pathway in breast cancer
Conclusions: Our study demonstrated that PAK7, as an oncogene, involved in breast cancer progression by activating the Wnt/β-catenin signaling pathway, suggesting that the potential applicability of PAK7 as a target for breast cancer treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Kai Li, Xiaolong Xu, Yanqi He, Yihao Tian, Wenting Pan, Liu Xu, Yanbin Ma, Yang Gao, Jingbo Gao, Yuwen Qi, Lei Wei, Jingwei Zhang Tags: Research Paper Source Type: research

Prognostic value of MET copy number gain in non-small-cell lung cancer: an updated meta-analysis
The alterations of MET have been detected in non-small-cell lung cancer (NSCLC). However, the prognostic impact of MET gene copy number gain (CNG) has not been consistent among studies. We performed this meta-analysis to evaluate the prognostic value of high MET CNG in patients with NSCLC. A systematic computerized search of the electronic databases including PubMed, EMBASE, Google scholar, and Cochrane Library (up to November 2017) was carried out. From twenty-one studies, 7,647 patients were included in the pooled analysis of hazard ratios (HRs) with 95% confidence intervals (CIs) for disease-free survival or overall sur...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jung Han Kim, Hyeong Su Kim, Bum Jun Kim Tags: Research Paper Source Type: research

Antagonistic role of GSK3 isoforms in glioma survival
GSK3 (Glycogen Synthase Kinase-3) function in brain is contributed by two distinct gene GSK3 alpha and GSK3 beta. Present findings indicate that imbalance in between GSK3 alpha and beta isoform contributes oncogenesis. In gliomas, GSK3 isoform specific functions are different then as reported for melanoma, prostate cancer, lung cancer etc. Both the isoforms of GSK3 are inversely regulating hnRNPA1 (RNA binding protein) expression, subsequently affecting RNA alternative splicing (BIN1, RON, Mcl1, PKM) in gliomas. Elevated expression of c-Myc, hnRNPA1, Phospo-ERK1/2 and Cyclin D1 in GSK3 alpha knock down cells, resembles GSK...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Vidhi Vashishtha, Nupur Jinghan, Ajay K.Yadav Tags: Research Paper Source Type: research

Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma
In this study, we investigated the expression level of eight selected cancer-related circRNAs including circ-Cdr1as, circ_HIPK3 and circ-ITCH in OS cell lines, tissues and plasmas by quantitative real-time polymerase chain reaction (qRT-PCR) and found that only circ_HIPK3 could stably down-regulate in the OS cell lines, tissues and plasmas than the corresponding controlled. One-way analysis of variance was further conducted to analyze the relationship between circ_HIPK3 expression level and clinic pathological factors of OS patients. Receiver operating characteristic (ROC) curve was built to evaluate the diagnostic values ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ma Xiao-Long, Zhu Kun-Peng, Zhang Chun-Lin Tags: Research Paper Source Type: research

Feasibility of continuing crizotinib therapy after RECIST-PD in advanced non-small cell lung cancer patients with ALK/ROS-1 mutations
Conclusion: Continuation of crizotinib therapy after RECIST-PD in Chinese NSCLC patients with positive ALK/ROS1 mutations is feasible in clinical practice. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jun Liu, Shaohua Cui, Feng Pan, Yiqian Ni, Hua Zhong, Liwen Xiong, Bo Jin, Tianqing Chu, Aiqin Gu, Liyan Jiang Tags: Research Paper Source Type: research

The Effect of Marital Status on Nasopharyngeal Carcinoma Survival: A Surveillance, Epidemiology and End Results Study
This study examined the role of marital status on survival outcome of nasopharyngeal carcinoma (NPC) patients using a population-based cancer registry.Methods: Patients with primary NPC diagnosed between 2004 and 2013 were included using the Surveillance, Epidemiology and End Results program. Patient demographic, clinicopathologic features, management, and survival outcomes were compared according to marital status. Cause-specific survival (CSS, NPC-related death) for marital status was analyzed.Results: The data of 3018 patients were included, with 61.4%, 11.1%, 21.8, and 5.6% of patients married, divorced (or separated),...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: San-Gang Wu, Qing-Hong Zhang, Wen-Wen Zhang, Jia-Yuan Sun, Qin Lin, Zhen-Yu He Tags: Research Paper Source Type: research

Prognostic value of C-reactive protein/albumin ratio in predicting overall survival of Chinese cervical cancer patients overall survival: comparison among various inflammation based factors
This study was a retrospective analysis of the data related to 229 patients with newly diagnosed cervical cancer. The potential prognostic factors were evaluated by univariate and multivariate survival analysis. The correlation between CRP/Alb ratio and other prognostic factors were analyzed by Chi-Square or Fisher's exact test.Results: Multivariate analyses showed that CRP/Alb ratio was an independent predictor of overall survival (OS) in cervical squamous cell carcinoma (SCC) (HR, hazard ratio = 2.529; p = 0.045), but not in all cases of cervical cancer. However, NLR was a prognostic factor in the whole cervical cancer (...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xia He, Jian-Pei Li, Xiao-Hua Liu, Jing-Ping Zhang, Qiu-Yao Zeng, Hao Chen, Shu-Lin Chen Tags: Research Paper Source Type: research

Genomic and epigenetic signatures associated with survival rate in oral squamous cell carcinoma patients
Conclusions: Genomic and epigenetic signatures were validated in a larger and geographically separate cohort, from TCGA database, which reinforce their clinical applicability. Noninvasive methodologies for detection of these signatures require further studies before translation in to clinical practice. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ilda Patr í cia Ribeiro, Francisco Caramelo, Lu í sa Esteves, Camila Oliveira, Francisco Marques, Leonor Barroso, Joana Barbosa Melo, Isabel Marques Carreira Tags: Research Paper Source Type: research

Aberrant DNA methylation of the p16, APC, MGMT, TIMP3 and CDH1 gene promoters in tumours and the surgical margins of patients with oral cavity cancer
Oral cavity cancer is a type of head and neck squamous cell carcinoma (HNSCC) and contributes to significant morbidity and mortality each year. An epigenetic pathway of transcriptional inactivation for many genes has been described in various cancers, including HNSCC. For our study, we selected genes for which silencing caused by hypermethylation can promote cancer development. In 75 primary HNSCC tumours and paired surgical margins, we investigated the methylation status of the p16, APC, MGMT, TIMP3 and CDH1 gene promoters by methylation-specific PCR after bisulphite treatment. The promoter methylation rates of p16, APC, ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Joanna Katarzyna Strzelczyk, Ł ukasz Krakowczyk, Aleksander Jerzy Owczarek Tags: Research Paper Source Type: research

Risk Factors of the Recurrences of Pancreatic Solid Pseudopapillary Tumors: A Systematic Review and Meta-analysis
Conclusion: Factors including a larger tumor size (diameter> 5cm), lymphovascular invasion, lymph node metastasis, synchronous metastasis and positive margin may increase the risk of recurrences of resected pancreatic SPTs. All SPTs should be excised and patients with high-risk features should undergo a long-term follow-up. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hao Gao, Yong Gao, Lingdi Yin, Guangfu Wang, Jishu Wei, Kuirong Jiang, Yi Miao Tags: Research Paper Source Type: research

Mycophenolate Mofetil induces c-Jun-N-terminal kinase expression in 22Rv1 cells: an impact on androgen receptor signaling
In conclusion, we suggest that, castrate-resistant prostate cancers progression might be retarded with the combination of MYC and chemical JNK inhibitors, involving AR-dependent mechanism. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ondrej Zenata, Zdenek Dvorak, Radim Vrzal Tags: Research Paper Source Type: research

The innovative regularity and role of p16 methylation in blood during HCC development
Conclusions: HCC pathogenesis affecting p16 methylation don't work during normal blood, when from benign diseases to HCC bloods, can produce powerful role. The transcriptional inactivation associated with p16 methylation might start from benign liver disease, and might be increased from benign liver disease to HCC process. p16 methylation in blood can be used as a promising non-invasive biomarker to HCC's prediction and diagnosis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Cheng-Gang Jiang, Qun Chen, Lina Wu, Guang Wang, Jianzhong Ma Tags: Research Paper Source Type: research

MLH1 Promoter Methylation and Prediction/Prognosis of Gastric Cancer: A Systematic Review and Meta and Bioinformatic Analysis
Background: The promoter methylation of MLH1 gene and gastric cancer (GC)has been investigated previously. To get a more credible conclusion, we performed a systematic review and meta and bioinformatic analysis to clarify the role of MLH1 methylation in the prediction and prognosis of GC.Methods: Eligible studies were targeted after searching the PubMed, Web of Science, Embase, BIOSIS, CNKI and Wanfang Data to collect the information of MLH1 methylation and GC. The link strength between the two was estimated by odds ratio with its 95% confidence interval. The Newcastle-Ottawa scale was used for quantity assessment. Subgrou...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shixuan Shen, Xiaohui Chen, Hao Li, Liping Sun, Yuan Yuan Tags: Research Paper Source Type: research

Analysis of Differential Expressions of Long Non-coding RNAs in Nasopharyngeal Carcinoma Using Next-generation Deep Sequencing
Conclusion: These findings broadened the lncRNAs landscape of NPC tissues and shed light on the roles of these lncRNAs, which might be conducive to the comprehensive management of NPC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiao-xiao Li, Xu-jun liang, Liu-ying Zhou, Rui-jie Liu, Wu Bi, Sai Zhang, Shi-sheng Li, Wen-hui Yang, Zhu-chu Chen, Xin-ming Yang, Peng-fei Zhang Tags: Research Paper Source Type: research

Trends and Outcomes of Sentinel Lymph Node Biopsy in Early-stage Vulvar Squamous Cell Carcinoma: A Population-based Study
Purpose: To compare trends and outcomes between lymphadenectomy and sentinel lymph node biopsy (SLNB) in node-negative early-stage vulvar squamous cell carcinoma (SCC) using a population-based cancer registry.Methods: Patients with vulvar SCC registered on the Surveillance, Epidemiology, and End Results program between 2003 and 2013 were identified. Statistical analysis was performed using Cox regression proportional hazards to calculate hazard ratio (HR) and 95% confidence interval (CI). A 1:1 propensity score matching (PSM) method was performed to minimize selection bias.Results: A total of 1475 patients were identified,...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Juan Zhou, Wen-Wen Zhang, Xue-Ting Chen, San-Gang Wu, Jia-Yuan Sun, Qiong-Hua Chen, Zhen-Yu He Tags: Research Paper Source Type: research

Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma
Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in patients with cancer occurring in the same location. For preliminary isolation of neutrophils (PMNs), we used Polymorphprep™, then sorted with Microbeads. The cells were recorded in the incubation chamber with a BD Pathway 855 microscope system. Flow cytometric data (MPO+ neutrophils) were acquired on FACSCa...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Marzena Garley, Dorota Dziemia ń czyk-Pakie ł a, Kamil Grubczak, Arkadiusz Sura ż y ń ski, Dorota D ą browska, Wioletta Ratajczak-Wrona, Jolanta Sawicka-Powierza, Jan Borys, Marcin Moniuszko, Jerzy A. Pa ł ka, Ewa Jab ł o ń ska Tags: Research Paper Source Type: research

Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
In this study, we reviewed the most relevant researches in this field, and described the relationships between ncRNAs and chemoresistance in ovarian cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yang Shao, Hui Li, Ran Du, Jiao Meng, Gong Yang Tags: Review Source Type: research

Aerosol Immunotherapy with or without Cisplatin for metastatic lung cancer non-small cell lung cancer disease: In vivo Study. A more efficient combination
Lung cancer is the leading cause of cancer death after prostate cancer for males and breast cancer for females. There are novel therapies in the past five years such as; tyrosine kinase inhibitors and most recently in the last two years immunotherapy. Immunotherapy is currently being investigated if it can be administered alone or in combination. Previously we have investigated whether immunotherapy compounds can be produced as aerosols, and in the current study we investigated the safety and efficiency independently of the programmed death-ligand 1. The aerosol administration of both cisplatin and nivolumab is possible. T...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Konstantinos Sapalidis, Paul Zarogoulidis, Efstathios Pavlidis, Stella Laskou, Athanasios Katsaounis, Charilaos Koulouris, Dimitrios Giannakidis, Stylianos Mantalovas, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Chrysanthi Sardeli, Aikaterini Amaniti, Tags: Research Paper Source Type: research

From First Line to Sequential Treatment in the Management of Metastatic Pancreatic Cancer
The current management of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) is based on systemic chemotherapy. The results of the MPACT and PRODIGE clinical trials have demonstrated that the combination of nab-paclitaxel and gemcitabine (GEM) as well as FOLFIRINOX regimen result in improvement in overall survival when compared to GEM alone. Treatment guidelines now recommend either one of these two regimens as first line treatment for fit patients with mPDAC. Because no head-to-head comparison between the two regimens exists, the selection of one versus the other is based on clinical criteria. The design an...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Andr é s Mu ñ oz Mart í n, Manuel Hidalgo, Rafael Alvarez, Virginia Arrazubi, Joaquina Mart í nez-Gal á n, Mercedes Salgado, Teresa Macarulla, Alfredo Carrato Tags: Review Source Type: research

Development Of A Three-Gene Prognostic Signature For Hepatitis B Virus Associated Hepatocellular Carcinoma Based On Integrated Transcriptomic Analysis
Integration of public genome-wide gene expression data together with Cox regression analysis is a powerful weapon to identify new prognostic gene signatures for cancer diagnosis and prognosis. Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), however, it remains largely unknown about the specific gene prognostic signature of HBV-associated HCC. Using Robust Rank Aggreg (RRA) method to integrate seven whole genome expression datasets, we identified 82 up-regulated genes and 577 down-regulated genes in HBV-associated HCC patients. Combination of several enrichment analysis, univariate and multivaria...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yao Yang, Qian Lu, Xuejun Shao, Banghui Mo, Xuqiang Nie, Wei Liu, Xianhua Chen, Yuan Tang, Youcai Deng, Jun Yan Tags: Research Paper Source Type: research

Construction of a human monoclonal antibody against bFGF for suppression of NSCLC
Compelling evidence implicates that overexpression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer (NSCLC) drives tumor progression, can serve as prognostic biomarkers or therapeutic targets for NSCLC patients. But at present, we still lack of effective drugs for bFGF. The preparation of monoclonal antibodies against bFGF or to understand its mechanism of action is urgently need. Previously, we used hybridoma technology to produce a murine anti-bFGF monoclonal antibody (E12). However, E12 carries risks of heterogeneity and immunogenicity. In the present...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Sheng Wang, Yiyang Qin, Zhongmin Wang, Junjian Xiang, Yu Zhang, Meng Xu, Baiyong Li, Yu Xia, Peng Zhang, Hong Wang Tags: Research Paper Source Type: research