New novel non-MHC genes were identified for cervical cancer with an integrative analysis approach of transcriptome-wide association study
Although genome-wide association studies (GWAS) have successfully identified multiple genetic variants associated with cervical cancer, the functional role of those variants is not well understood. To bridge such gap, we integrated the largest cervical cancer GWAS (N = 9,347) with gene expression measured in six human tissues to perform a multi-tissue transcriptome-wide association study (TWAS). We identified a total of 20 associated genes in the European population, especially four novel non-MHC genes (i.e. WDR19, RP11-384K6.2, RP11-384K6.6 and ITSN1). Further, we attempted to validate our results in another independent c...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Haimiao Chen, Ting Wang, Shuiping Huang, Ping Zeng Tags: Research Paper Source Type: research

Genomic variants in Fas-mediated apoptosis pathway predict a poor response to Platinum-based Chemotherapy for Chinese Gastric Cancer Patients
Platinum-based adjuvant chemotherapy is very common for gastric cancer (GC) patients, but the chemotherapy sensitivity is very heterogeneous. The genomic variants and the gene-gene interactions involved in Fas-mediated apoptosis pathway including Fas (FAS 1377 G > A and 670 A > G), FasL (FASL 844 C > T) and caspase-8 (CASP8 -652 6N ins > del or I > D), may paly vital roles in the response to platinum-based treatment. In our investigation, 662 stage II-III postoperative GC patients were enrolled between 1998 and 2006. 261 patients accepted platinum-based regimens and the remaining 401 were not. The log r...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Tingting Zhao, Wei Li, Jinfei chen, Weisong Qin Tags: Research Paper Source Type: research

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway
Conclusions: DTX3 suppresses EMT by partially facilitating ubiquitination of XRCC5 to inhibit AKT signal pathway in PTC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Lidong Wang, Yonglian Huang, Chenxi Liu, Mingyue Guo, Zhennan Ma, Jingni He, Ailian Wang, Xiaodan Sun, Zhen Liu Tags: Research Paper Source Type: research

Identifying Key Genes for Nasopharyngeal Carcinoma by Prioritized Consensus Differentially Expressed Genes Caused by Aberrant Methylation
Conclusions: Our integrative analysis provides reliable key genes for candidate biomarkers for diagnosis and prognosis in NPC. Based on the combined evidence of promoter hypermethylation, expression up-regulation, and association with overall survival, genes such as SCUBE2, PRKCB, IKZF1, MAP4K1, and GATA6 could be promising novel diagnostic biomarkers, and miRNAs including MIR150, MIR152, and MIR34 could be candidate prognosis biomarkers. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yunqin Chen, Chun Zhou, Huabin Li, Hong Li, Yixue Li Tags: Research Paper Source Type: research

Prognostic implication of glycolysis related gene signature in non-small cell lung cancer
In conclusion, we constructed a novel glycolysis related risk signature which might contribute to predicting the prognosis of NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jie Yao, Rui Li, Xiao Liu, Xijia Zhou, Jianping Li, Tingting Liu, Chen Huo, Yiqing Qu Tags: Research Paper Source Type: research

Six Novel Biomarkers for Diagnosis and Prognosis of Esophageal squamous cell carcinoma: validated by scRNA-seq and qPCR
In conclusion, our results suggest that PBK, KIF2C, NUF2, KIF20A, RAD51AP1 and DEPDC1 are all potential biomarkers for ESCC diagnosis and prognosis may also be potential therapeutic targets for ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Liuhai Zheng, Linzhi Li, Jun Xie, Hai Jin, Naishuo Zhu Tags: Research Paper Source Type: research

A phase II study of gemcitabine, erlotinib and S-1 in patients with advanced pancreatic cancer
Conclusion: The combination of gemcitabine, erlotinib, and S-1 provided an acceptable toxicity profile and modest clinical benefits in patients with advanced pancreatic cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Boram Han, Bum Jun Kim, Hyeong Su Kim, Dae Ro Choi, Byoung Yong Shim, Kyung Hee Lee, Jin Won Kim, Jung Han Kim, Hunho Song, Jong Hyeok Kim, Choong Kee Park, Jung Woo Lee, Min-Jeong Kim, Dae Young Zang Tags: Research Paper Source Type: research

Upregulated expression of serum exosomal hsa_circ_0026611 is associated with lymph node metastasis and poor prognosis of esophageal squamous cell carcinoma
Conclusion: Serum exosomal hsa_circ_0026611 expression is significantly upregulated in ESCC with lymph node metastasis and is a predictor of ESCC prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Shuang Liu, Zheng Lin, Wenqing Rao, Jing Zheng, Qianwen Xie, Yulan Lin, Xi Lin, Huilin Chen, Yuanmei Chen, Zhijian Hu Tags: Research Paper Source Type: research

A novel prognosis marker based on combined preoperative carcinoembryonic antigen and systemic inflammatory response for resectable gastric cancer
Conclusions: The CNLR prognostic scoring system established by combining CEA and NLR is an independent prognostic factor for GC, which can be incorporated into the traditional TNM staging to improve the prediction of long-term survival outcomes. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yubin Ma, Junpeng Lin, Jianxian Lin, Junfang Hou, Qin Xiao, Fang Yu, Zhijun Ma, Ping Li, Ruhong Tu, Jianwei Xie, Chaohui Zheng, Su Yan, Changming Huang Tags: Research Paper Source Type: research

Novel biomarkers and prediction model for the pathological complete response to neoadjuvant treatment of triple-negative breast cancer
Conclusions: This study provided a robust prediction model for pCR rate and revealed potential mechanisms of distinct response to NCT in TNBC, which were promising and warranted to further validate in the perspective. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yiqun Han, Jiayu Wang, Binghe Xu Tags: Research Paper Source Type: research

The added value of CA125 normalization before interval debulking surgery to the chemotherapy response score for the prognostication of ovarian cancer patients receiving neoadjuvant chemotherapy for advanced disease
Conclusion: Both the CRS system and the normalization of CA125 following NACT could reliably predict the risk of recurrence following primary treatment. The combination of the two factors refined the prognostic stratification of HGSC patients who were treated with NACT and IDS. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Wei-feng Liang, Li-juan Wang, Hui Li, Chang-hao Liu, Miao-fang Wu, Jing Li Tags: Research Paper Source Type: research

Autophagy-mediated tumor cell survival and progression of breast cancer metastasis to the brain
Brain metastases represent a substantial amount of morbidity and mortality in breast cancer (BC). Metastatic breast tumor cells committed to brain metastases are unique because they escape immune surveillance, can penetrate the blood-brain barrier, and also adapt to the brain tissue microenvironment (TME) for colonization and outgrowth. In addition, dynamic intracellular interactions between metastatic cancer cells and neighboring astrocytes in the brain are thought to play essential roles in brain tumor progression. A better understanding of the above mechanisms will lead to developing more effective therapies for brain m...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Aparna Maiti, Nitai C. Hait Tags: Review Source Type: research

Infiltrating Immune Cells in Gastric Cancer: A Novel Predicting Model for Prognosis
Conclusion: In summary, tumor-infiltrating immune cells play an essential role in GC progression and affect the outcome of GC patients. The immune risk score can predict overall survival for GC independently, and high immune risk score is associated with poor prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Wenjie Li, Mengting Li, Haizhou Wang, Yanan Peng, Shouquan Dong, Yuanyuan Lu, Fan Wang, Fei Xu, Lan Liu, Qiu Zhao Tags: Research Paper Source Type: research

JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation
JMJD8 is a JmjC domain-containing protein that has not been widely examined, despite its potential role in malignant tumor development. The underlying biological functions and molecular mechanisms of JMJD8 in non-small-cell lung cancer (NSCLC) remain unclear. Herein, we explored the relationship between JMJD8 and the activation of malignancy pathways in NSCLC. Immunohistochemical analyses revealed that high JMJD8 expression significantly correlated with cell differentiation and advanced TNM stages of NSCLC. The overexpression of JMJD8 promoted cell proliferation and invasion in vitro. Upon JMJD8 knockdown in lung cancer ce...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Bo Zhang, Yao Zhang, Xizi Jiang, Hongbo Su, Qiongzi Wang, Muli Wudu, Jun Jiang, Hongjiu Ren, Yitong Xu, Zongang Liu, Xueshan Qiu Tags: Research Paper Source Type: research

UC2288 induces cell apoptosis of nasopharyngeal carcinoma cells via inhibiting EGFR/ERK pathway
In conclusion, UC2288 suppressed the growth of NPC via inhibiting EGFR/ERK pathway and it may be a promising therapeutic option for NPC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Renba Liang, Xiaodong Zhu Tags: Research Paper Source Type: research