Surgical Treatment of Combined Hepatocellular-Cholangiocarcinoma is as Effective in Elderly Patients as it is in Younger Patients: A Propensity Score Matching Analysis
Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center.Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall survival (OS) and disease-free survival (DFS) of elderly patients (age≥60, n=52) and younger patients (age
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chen-Yang Tao, Wei-Ren Liu, Lei Jin, Zheng Tang, Meng-Xin Tian, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Yuan Fang, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Ying-Hong Shi Tags: Research Paper Source Type: research

Usefulness of Bronchoscopic Rebiopsy of Non-Small Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor
Conclusions: Bronchoscopy was more useful than other rebiopsy approaches. The T790M emergence rate was highest in cases with exon 19 deletion, likely as a consequence of long-term EGFR-TKI exposure. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Eun Kyong Goag, Jung Mo Lee, Kyung Soo Chung, Song Yee Kim, Ah Young Leem, Joo Han Song, Ji Ye Jung, Moo Suk Park, Yoon Soo Chang, Young Sam Kim, Joon Chang, Eun Young Kim Tags: Research Paper Source Type: research

Inhaled Immunotherapy Administration for Lung Cancer; Efficient? Certainly Possible
Lung cancer is still diagnosed at a late stage in most lung cancer patients. Regarding Non-small Cell lung cancer there are novel therapies such as; tyrosine kinase inhibitors and immunotherapy. Currently we have two immunotherapies that can be used either as first-line treatment or second line treatment; pembrolizumab and nivolumab. A third one is being investigated as a combination of immunotherapy; ipilimumab. Aerosol treatment has been investigated for many diseases not only for the lung, but also for systematic diseases. The design of cups was found the most significant factor in producing significant effects. The com...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Konstantinos Sapalidis, Paul Zarogoulidis, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Konstantina Boniou, Ilias Karapantzos, Chrysanthi Karapantzou, Michael Karanikas, Vasilis Thomaidis, Christoforos Kosmidis, Chrysanthi Sardeli, Naim Benhassen, Yan-G Tags: Research Paper Source Type: research

Prognostic value of preoperative lymphocyte-monocyte ratio in patients with ovarian clear cell carcinoma
Conclusions: Markers of systemic inflammatory response provide useful prognostic information and lymphocyte-to-monocyte ratio is the most reliable independent prognostic factor of overall survival in patients with ovarian clear cell carcinoma. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Byung Su Kwon, Dae Hoon Jeong, Jung Mi Byun, Tae Hwa Lee, Kyung Un Choi, Yong Jung Song, Dong Soo Suh, Ki Hyung Kim Tags: Research Paper Source Type: research

Up-regulation Of EIF3e Is Associated with The Progression of Esophageal Squamous Cell Carcinoma and Poor Prognosis in Patients
Conclusions: The eIF3e expression, or combined with other members of eIF3 complex, might predict poor prognosis of ESCC and serve as a potential breakthrough in the multimodality therapy of ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Fengkai Xu, Jie Gu, Lin Wang, Ronghua Liu, Yunfeng Yuan, Hao Wang, Jiahao Jiang, Wei Mao, Chunlai Lu, Di Ge Tags: Research Paper Source Type: research

Phase I/II clinical trial of everolimus combined with gemcitabine/cisplatin for metastatic triple-negative breast cancer
Conclusions: Although the majority of patients with metastatic TNBC demonstrated PIK3CA mutations in cfDNA, the addition of everolimus to gemcitabine/cisplatin did not have a synergistic effect in these patients. Further studies are needed to determine the most effective way to target the PI3K/AKT/mTOR pathway in TNBC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: In Hae Park, Sun-Young Kong, Youngmee Kwon, Min Kyeong Kim, Sung Hoon Sim, Jungnam Joo, Keun Seok Lee Tags: Research Paper Source Type: research

Nomograms to Predict Individual Prognosis of Patients with Primary Small Cell Carcinoma of the Bladder
Conclusions: We proposed the first two nomograms for individualized prediction of OS and CSS in SCCB patients with satisfactory predictive accuracy, good robustness and wide applicability. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Fan Dong, Yifan Shen, Fengbin Gao, Xiao Shi, Tianyuan Xu, Xianjin Wang, Xiaohua Zhang, Shan Zhong, Minguang Zhang, Shanwen Chen, Zhoujun Shen Tags: Research Paper Source Type: research

Diagnostic accuracy of inflammatory markers for distinguishing malignant and benign ovarian masses
Objective: To evaluate the role of inflammatory markers for distinguishing malignant and benign ovarian masses.Methods: Preoperative demographic, clinicopathologic, and laboratory variables were reviewed in patients with an ovarian mass that was subsequently diagnosed as either epithelial ovarian cancer (EOC) or a benign ovarian mass on histologic analysis. The differences between variables of the two groups were further evaluated. Logistic regression analysis was applied to evaluate variables to predict the presence of EOC.Results: According to the analysis of 229 patients with EOC, 120 (52.4%) patients had serous adenoca...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wan Kyu Eo, Ki Hyung Kim, Eun Joo Park, Heung Yeol Kim, Hong-bae Kim, Suk Bong Koh, Jeong Namkung Tags: Research Paper Source Type: research

Baseline Metabolic Risk Score and Postsurgical Esophageal Cancer-Specific Mortality: The Fujian Prospective Investigation of Cancer (FIESTA) Study
Backgrounds: Compelling evidence has emerged to support a close relationship between metabolic syndrome and esophageal cancer (EC).Aims: Using five baseline metabolism-related markers, we constructed a metabolic risk score (MRS), aiming to test whether MRS can improve the prediction of postsurgical EC-specific mortality over traditional demographic and clinicopathologic characteristics.Methods: Total 2535 EC patients who received three-field lymphadenectomy were enrolled from January 2000 to December 2010, and they were followed up until December 2015.Results: All EC patients were randomly split into derivation group (n=15...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hong Sha, Dan Hu, Sinan Wu, Feng Peng, Guodong Xu, Guohui Fan, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu Tags: Research Paper Source Type: research

Hepatitis B Virus Infection Dampens CtIP Expression in Hepatoma Cell
Hepatitis B virus (HBV) infection is a leading cause for hepatocellular carcinoma (HCC). Dysregulation of DNA double-strand break (DSB) repair may explain the pathogenesis of HBV-related HCC. Tumor suppressor CtIP plays a critical role in DSB repair. The purpose of present study was to clarify whether HBV affects CtIP expression in DSB repair of hepatoma cell. HepG2.2.15 was selected as the HBV positive hepatoma cell line, while HepG2 as the HBV negative hepatoma cell line. The two cell lines were treated with bleomycin to induce DSB. Bleomycin treatment could result in DSB by γ-H2AX detection. CtIP gene expression w...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Dongxin Zhang, Haojing Liu, Jusheng Lin, Duyun Ye Tags: Research Paper Source Type: research

The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China
Conclusions: In spite of the worse outcome in survival curve of stage I~IV GC cohort, young patients with gastrectomy presented favorable survival in M0 subgroup. It is also applicable in China. Early diagnosis and treatment should be taken seriously in young GC patients since they often possess poorer characteristics but benefited more from gastrectomy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jieyun Zhang, Lu Gan, Mi-die Xu, Mingzhu Huang, Xiaowei Zhang, Yiwei Gong, Xi Wang, Guanzhen Yu, Weijian Guo Tags: Research Paper Source Type: research

A Network Meta-analysis Comparing the Efficacy and Safety of Anti-PD-1 with Anti-PD-L1 in Non-small Cell Lung Cancer
Conclusions: Anti-PD-1 may be a better choice for patients with metastatic and previously treated NSCLC who failed first-line treatment in terms of the treatment ranking. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wei You, Mei Liu, Ji-Dong Miao, Yu-Qian Liao, Yi-Bing Song, Dian-Kun Cai, Yang Gao, Hao Peng Tags: Research Paper Source Type: research

Synergistic antitumor effects of cMet inhibitor in combination with anti-VEGF in colorectal cancer patient-derived xenograft models
In this study, the expression of cMet in 146 Chinese colorectal cancer (CRC) patients was examined by immunohistochemistry staining. Our data demonstrated that cMet overexpression rate was 42.5% (62/146) and cMet overexpression was closely correlated with distant metastasis of CRC. Using CRC patient-derived xenograft (PDX) mouse models we investigated antitumor activity of a novel selective cMet inhibitor volitinib alone or in combination with anti-VEGF inhibitor apatinib in vivo. Our results showed that combination treatment significantly inhibited tumor growth in two PDX models. While volitinib treatment alone induced mo...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiangheng Chen, Zhonghai Guan, Jun Lu, Haohao Wang, Zhongkun Zuo, Fei Ye, Jiangsheng Huang, Lisong Teng Tags: Research Paper Source Type: research

MiR-490-3p Functions As a Tumor Suppressor by Inhibiting Oncogene VDAC1 Expression in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common cancers worldwide, usually with poor prognosis because many CRC patients are diagnosed at an advanced stage. Therefore, novel potential diagnostic and prognostic biomarkers are urgently needed. MicroRNAs have been reported to regulate a variety of biological processes, such as cell proliferation, differentiation and apoptosis. Accumulating studies have demonstrated that miR-490-3p could regulate the development and progression of multiple cancers, but its clinical significance and molecular mechanism in CRC are still elusive. Here, we try to further elucidate the regulatory...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiangxiang Liu, Bangshun He, Tao Xu, Yuqin Pan, Xiuxiu Hu, Xiaoxiang Chen, Shukui Wang Tags: Research Paper Source Type: research

Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma
Purpose: The value of 18F-fluorodeoxyglucose positron emission tomography /computed tomography (18F-FDG PET/CT) in assessing bone marrow involvement (BMI) of lymphoma remains controversial. The present study aims to evaluate the prognostic meaning of bone marrow FDG uptake pattern in PET/CT of newly diagnosed diffuse large B-cell lymphoma (DLBCL) patients.Materials and Methods: 193 newly diagnosed DLBCL patients were retrospectively analyzed. All patients received 6-8 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). The type of BM FDG uptake pattern was recorded by two blinded re...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yumei Chen, Mingge Zhou, Jianjun Liu, Gang Huang Tags: Research Paper Source Type: research

Association of WWOX rs9926344 polymorphism with poor prognosis of hepatocellular carcinoma
Conclusion: Our findings indicate that WWOX rs9926344 polymorphism is positively correlated with tumor recurrence and can be used as an independent prognostic marker for HCC patients after operation. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wanyong Chen, Chenhao Zhou, Wentao Zhang, Manar Atyah, Yirui Yin, Lei Guo, Weiguo Tang, Qiongzhu Dong, Qinghai Ye, Ning Ren Tags: Research Paper Source Type: research

Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells
Lung cancer (LC) is the most common cause of death from cancer worldwide, and it is also a closely aging-related disease. Klotho, a new anti-aging gene, has been proven to play a critical role in regulating aging and the development of age-related diseases including LC. However, whether Klotho is a key link between aging and LC is still unknown. Here we report that Klotho can indirectly inhibit LC growth and development through regulating senescence-associated secretory phenotype (SASP). We found that senescent lung fibroblasts (SLF) can promote production of IL-6 and IL-8, which can be effectively inhibited by overexpress...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Bo Chen, Yan Liang, Liben Chen, Yunyan Wei, Yue Li, Weihong Zhao, Jianqing Wu Tags: Research Paper Source Type: research

Reassessing the Potential of Myb-targeted Anti-cancer Therapy
Transcription factor MYB is essential for the tumorigenesis of multiple cancers, especially leukemia, breast cancer, colon cancer, adenoid cystic carcinoma and brain cancer. Thus, MYB has been regarded as an attractive target for tumor therapy. However, pioneer studies of antisense oligodeoxynucleotides against MYB, which were launched three decades ago in leukemia therapy, were discontinued because of their unsatisfactory clinical outcomes. In recent years, the roles of MYB in tumor transformation have become increasingly clear. Moreover, the regulatory mechanisms of MYB, such as the vital effects of MYB co-regulators on ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiaofeng Liu, Yunxiao Xu, Liping Han, Yan Yi Tags: Review Source Type: research

Increased AURKA Gene Copy Number Correlates with Poor Prognosis and Predicts the Efficacy of High-dose Interferon Therapy in Acral Melanoma
In this study, AURKA copy gain (set as more than 2.0 copies) was detected in 24.6% (116/472) of the samples. We did not observe any obvious correlation between clinicopathological characteristics and AURKA copy gain of the patients. However, patients with AURKA copy gain had a significantly shorter overall survival time (OS) and progression-free survival time (PFS) than those with normal AURKA CN (OS: P = 0.022; PFS: P
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Junya Yan, Jiayi Yu, Xiaowen Wu, Tianxiao Xu, Huan Yu, Jie Dai, Meng Ma, Huan Tang, Longwen Xu, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Yan Kong, Jun Guo Tags: Research Paper Source Type: research

Wnt signaling in cervical cancer?
Cervical cancer (CC) is the second most common malignant cancer in women. CC is difficult to diagnose, has a high recurrence rate, and is resistant to systemic therapies; as a result, CC patients have a relatively poor prognosis. One potential link to CC is the Wnt signaling pathway and its downstream effectors, which regulate cell differentiation, proliferation, migration, and fate. The aberrant activation of Wnt signaling is associated with various cancers, including CC. Recent studies have shown that activating or inhibiting the intracellular signal transduction in this pathway can regulate cancer cell growth and viabil...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Min Yang, Min Wang, Xianping Li, Yixin Xie, Xiaomeng Xia, Jingjing Tian, Kan Zhang, Aiguo Tang Tags: Review Source Type: research

Evaluation of Detection Methods and Values of Circulating Vascular Endothelial Growth Factor in Lung Cancer
Lung cancer is the deadliest cancer in the world. Angiogenesis plays a crucial role of the incidence, progression, and metastasis in lung cancer. Angiogenesis inhibitors are used to treat non-small cell lung cancer (NSCLC) patients, and the molecular biomarkers are also being assessed to predict treatment response/therapeutic response and patients' prognosis. Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates angiogenesis. Due to its predictive values of prognosis on NSCLC, a large number of methods have been developed and evaluated to detect VEGF levels in a variety of studies....
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Sumin Guo, Michael G. Martin, Cheng Tian, Jinglin Cui, Lishi Wang, Shucai Wu, Weikuan Gu Tags: Review Source Type: research

A Survival Model in Locally Advanced and Metastatic Pancreatic Ductal Adenocarcinoma
The prognostic role of serum LDH, CA19-9, CRP and ALB in PDAC patients are controversial. In contrast to single factor, there is much less information about the prognostic value of the combination of the four factors in locally advanced and metastatic PDAC patients. It's essential to set up a survival model with the combination of tumor metabolism, tumor biomarker, systemic inflammation and nutritional status to eliminate the prognostic inaccuracy in single biomarker. 94 advanced PDAC patients who received palliative chemotherapy from 2009 to 2017 were recruited for this study. The predictive value of pretreatment serum LD...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yi Wang, Xiuying Xiao, Tianyi Wang, Lin Li, Yue Zhu, Haiyan Xu, Yuening Chu, Feng Jiao, Jiujie Cui, Liwei Wang Tags: Research Paper Source Type: research

Patterns of Failure and Survival Trends Of 720 Patients with Stage I Nasopharyngeal Carcinoma Diagnosed from 1990-2012: A Large-scale Retrospective Cohort Study
Objectives: To evaluate the patterns of failure and survival trends of patients with stage I nasopharyngeal carcinoma (NPC) treated with radiotherapy alone over the last 20 years.Materials and Methods: A retrospective cohort study was conducted on 720 patients with stage I NPC who were treated with curative two-dimensional radiotherapy (2DRT), three-dimensional conformal radiotherapy (3DRT), or intensity-modulated radiotherapy (IMRT) between January 1990 and December 2012. The patients were categorized into four calendar periods (1990-1996, 1997-2002, 2003-2007, and 2008-2012) and four age subgroups (18-39, 40-49, 50-59, a...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Lin-Quan Tang, Tong-Yu Lu, Yang Li, Shao-Yan Guo, Qi-Yu Zhong, Meng-Sha Zou, Bo-Lin Chen, Qing-Nan Tang, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Qiu-Yan Chen, Ling Guo, Hao-Yuan Mo, Rui Sun, Dong-Hua Luo, Chong Zhao, Chao-Nan Qian, Xiang Guo, Mu-Sheng Z Tags: Research Paper Source Type: research

Downregulation of BANCR Promotes Aggressiveness in Papillary Thyroid Cancer via the MAPK and PI3K Pathways
Recent evidence indicates that long non-coding RNAs play important roles in tumorigenesis and cancer progression. BRAF-activated non-protein coding RNA (BANCR) is a novel and potential regulator of cancer cell proliferation and migration. However, little is known regarding the role of BANCR in papillary thyroid cancer (PTC). The current study used quantitative PCR to demonstrate that BANCR was significantly downregulated in 60 paired PTC tissues compared with normal tissues. In addition, BANCR was significantly correlated with lymph node metastasis (p = 0.02). Furthermore, Cell Counting Kits and Transwell assays were used ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jinjun Zhang, Yaying Du, Xiaoxue Zhang, Mengchen Li, Xingrui Li Tags: Research Paper Source Type: research

Verteporfin inhibits papillary thyroid cancer cells proliferation and cell cycle through ERK1/2 signaling pathway
Verteporfin, a FDA approved second-generation photosensitizer, has been demonstrated to have anticancer activity in various tumors, but not including papillary thyroid cancer (PTC). In current pre-clinical pilot study, we investigate the effect of verteporfin on proliferation, apoptosis, cell cycle and tumor growth of PTC. Our results indicate verteporfin attenuates cell proliferation, arrests cell cycle in G2/S phase and induces apoptosis of PTC cells. Moreover, treatment of verteporfin dramatically suppresses tumor growth from PTC cells in xenograft mouse model. We further illustrate that exposure to MEK inhibitor U0126 ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Tian Liao, Wen-Jun Wei, Duo Wen, Jia-Qian Hu, Yu Wang, Ben Ma, Yi-Min Cao, Jun Xiang, Qing Guan, Jia-Ying Chen, Guo-Hua Sun, Yong-Xue Zhu, Duan-Shu Li, Qing-Hai Ji Tags: Research Paper Source Type: research

A Real-World Data Study to Evaluate Treatment Patterns, Clinical Characteristics and Survival Outcomes for First- and Second-Line Treatment in Locally Advanced and Metastatic Urothelial Cancer Patients in Germany
The objective of this study was to describe clinical characteristics, treatment patterns and subsequent outcomes in this setting.Methods: This retrospective observational cohort analysis evaluated 1L and 2L treatment patterns and overall survival (OS) in patients aged ≥18 years with advanced UC or mUC (T4b, N2-3 and/or M1) at office-based urology and academic as well as nonacademic urology clinics throughout Germany between 1 November 2009 and 2 June 2016. Data were obtained through the GermanOncology database and additional treatment centers using similar electronic case report forms.Results: Among the 435 patients inc...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: G ü nter Niegisch, Holger Gerullis, Shih-Wen Lin, Julie Pavlova, Adam Gondos, Anja Rudolph, Gabriele Haas, Nora Hennies, Mario W. Kramer Tags: Research Paper Source Type: research

TRIM32 promotes proliferation and confers chemoresistance to breast cancer cells through activation of the NF- κ B pathway
Dysregulation of TRIM32 has been implicated in several human cancers, however, its clinical significance and biological function in breast cancer have not been investigated. Using immunohistochemistry, we found that TRIM32 expression is upregulated in breast cancer tissues and that it correlates with advanced stage and poor prognosis. TRIM32 is also overexpressed in 4/7 breast cancer cell lines. CCK8 and colony formation assays showed that TRIM32 depletion inhibited proliferation and colony formation in the T47D cell line, while TRIM32 overexpression promoted MCF-7 cell growth and colony formation. Cell viability and Annex...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ting-Ting Zhao, Feng Jin, Ji-Guang Li, Ying-Ying Xu, Hui-Ting Dong, Qun Liu, Peng Xing, Guo-Lian Zhu, Hao Xu, Song-Cheng Yin, Zhi-Feng Miao Tags: Research Paper Source Type: research

Anti-Cervical Cancer Role of Matrine, Oxymatrine and Sophora Flavescens Alkaloid Gels and its Mechanism
Conclusions: SFA gels, like its active ingredients, can restrain cervical cancer cells proliferation, suppress cervical cancer cell migration, induce the apoptosis and cell cycle arrest in cervical cancer cells. SFA gels may be a potential anti-tumor therapeutic agent for treating cervical cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yu Jie Zhou, Ya Jie Guo, Xiao Li Yang, Zhou Luo Ou Tags: Research Paper Source Type: research

Long-Term Outcome of Oxaliplatin and Capecitabine (XELOX) Concomitant with Neoadjuvant Radiotherapy and Extended to the Resting Period in High Risk Locally Advanced Rectal Cancer
Conclusion: This intensified strategy with oxaliplatin and capecitabine (XELOX) administered concomitantly with neoadjuvant radiotherapy and then extended to the resting period in high-risk LARC patients is efficient. The long-term outcome is promising. Further study of this strategy is warranted. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jinghua Tang, Xiaojun Wu, Yanfang Bai, Yuanhong Gao, Wu Jiang, Lingheng Kong, Junzhong Lin, Desen Wan, Zhizhong Pan, Peirong Ding Tags: Research Paper Source Type: research

Association between the SNPs of the TOB1 gene and gastric cancer risk in the Chinese Han population of northeast China
In this study, 506 GC cases and 548 healthy controls (HCs) were collected to evaluate the association between the eleven SNPs (rs35220381, rs12950561, rs7221352, rs61482741, rs9303568, rs34700818, rs12949115, rs9903822, rs12601477, rs11656976 and rs4626) of the TOB1 gene and GC risk in the population of northeast China. The results showed that there were significant associations of haplotype GCCTTGC, haplotype ATCTTGG, and haplotype GCCACGC with GC risk (P
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hui Wang, Huiting Hao, Haonan Guo, Yuanyuan Wang, Xuelong Zhang, Lidan Xu, Jingcui Yu Tags: Research Paper Source Type: research

Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF
Breastfeeding is associated with a decreased risk of ovarian cancer. However, the mechanism underlying this apparent clinical benefit is unknown. Oxytocin (OXT), a hypothalamic nonapetide, plays a crucial role in many reproductive and behavioural functions. In recent year, OXT acts as a growth regulator in many kind of tumor tissues, through the activation of a specific G-coupled transmembrane receptor, the oxytocin receptor (OXTR). OXT has been proved to inhibit the proliferation, migration and invasion of ovarian cancer SKOV3 cells in vitro. But, the underlying mechanisms remain unknown. Here, we found OXT inhibited prol...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Haoyi Ji, Na Liu, Yingchun Yin, Xinmei Wang, Xiaoyang Chen, Jing Li, Jingxin Li Tags: Research Paper Source Type: research

Multiple Antigen Stimulating Cellular Therapy (MASCT) For Hepatocellular Carcinoma After Curative Treatment: A Retrospective Study
Conclusions: Although the MASCT group was not associated with significantly longer OS or DFS, the multiple-course MASCT group showed significantly improved overall survival after curative treatment, and the treatment procedures were well-tolerated. Multiple-course MASCT may therefore provide another choice for patients with HCC after curative treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yajing He, Yabing Guo, Jinzhang Chen, Xiaoyun Hu, Xiaoshuang Li, Yanjun Kong, Xiaoyong Zhang, Xiangjun Zhou, Li Liu, Jinlin Hou Tags: Research Paper Source Type: research

Protein arginine methyltransferase 8 gene enhances the colon cancer stem cell (CSC) function by upregulating the pluripotency transcription factor
Conclusion: PRMT8 may promote the formation of colon cancer stem cells and, thus, be considered a potential therapeutic target for the treatment of malignant colon tumor. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Haishan Lin, Bin Wang, Jing Yu, Jing Wang, Qin Li, Bangwei Cao Tags: Research Paper Source Type: research

Secretory Clusterin Mediates Oxaliplatin Resistance via the Gadd45a/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma
Conclusions: The results demonstrate that sCLU/Gadd45a/PI3K/Akt signaling represents a novel pathway that could regulate drug resistance in a one-way manner in HCC cells. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xin Wang, Fang Zou, Jingtao Zhong, Longtao Yue, Fuhai Wang, Honglong Wei, Guangsheng Yang, Tao Jin, Xiaofeng Dong, Jie Li, Peng Xiu Tags: Research Paper Source Type: research

LncRNA PCAT1 and its genetic variant rs1902432 are associated with prostate cancer risk
This study aimed to investigate the molecular mechanisms of lncRNA PCAT1 involved in PCa development and its genetic variant associated with PCa risk. We applied cell proliferation and apoptosis assays to assess the effect of PCAT1 on PCa cell phenotypes. In addition, the genome-wide profiling of gene expression was assessed from three pairs of DU145 cells transfected with PCAT1 overexpression vector or negative control (NC) vector. Furthermore, a case-control study was conducted to explore the associations of four tagging single nucleotide polymorphisms (tagSNPs) and PCa risk in 850 PCa cases and 860 cancer-free controls....
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qinbo Yuan, Haiyan Chu, Yuqiu Ge, Gaoxiang Ma, Mulong Du, Meilin Wang, Zhengdong Zhang, Wei Zhang Tags: Research Paper Source Type: research

Survival Outcomes for Patients with Surgical and Non-Surgical Treatments in Stages I-III Small-Cell Lung Cancer
This study was performed to evaluate the survival outcomes of surgery for stage I-III SCLC.Methods: This analysis used data from the Surveillance, Epidemiology, and End Results (SEER) database. All stage I-III (excluding N3 and Nx) SCLC patients received a diagnosis between 2004 and 2014. Overall survival (OS) and lung cancer-specific survival (LCSS) were determined by Kaplan-Meier analysis and compared using the log-rank test. A Cox proportional hazard model identified relevant survival variables.Results: A total of 4,780 histologically confirmed patients were identified from the SEER database, comprising 1,018 patients (...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Keying Che, Hongchang Shen, Xiao Qu, Zhaofei Pang, Yuanzhu Jiang, Shaorui Liu, Xudong Yang, Jiajun Du Tags: Research Paper Source Type: research

Survivorship and Advocacy in Inflammatory Breast Cancer
In February 2017, the Morgan Welch Inflammatory Breast Cancer (IBC) Research Program and Clinic hosted a scientific conference in Houston to commemorate the tenth anniversary of the opening of the first IBC-dedicated clinic in the world. Attendees included basic science researchers, clinicians who treat IBC, as well as patients and their caregivers. Several US-based and international IBC-focused nonprofit organizations were also represented. In this third paper from the conference, we report on the breakout session regarding survivorship and advocacy issues related to IBC, sharing an overview of the educational content pre...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Angela Alexander, Terry Lynn Arnold, Sandra Bishnoi, Caroline Ballinger, Simona F. Shaitelman, Mark V. Schaverien, Lorenzo Cohen, Mary Dev, Naoto T. Ueno Tags: Research Report Source Type: research

International Consensus on the Clinical Management of Inflammatory Breast Cancer from the Morgan Welch Inflammatory Breast Cancer Research Program 10th Anniversary Conference
National and international experts in inflammatory breast cancer (IBC) from high-volume centers treating IBC recently convened at the 10th Anniversary Conference of the Morgan Welch Inflammatory Breast Cancer Research Program at The University of Texas MD Anderson Cancer Center in Houston Texas. A consensus on the clinical management of patients with IBC was discussed, summarized, and subsequently reviewed. All participants at the conference (patients, advocates, researchers, trainees, and clinicians) were queried using the MDRing electronic survey on key management issues. A summary of the expert consensus and participant...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Naoto T. Ueno, Jose Rodrigo Espinosa Fernandez, Massimo Cristofanilli, Beth Overmoyer, Dan Rea, Fedor Berdichevski, Mohamad El-Shinawi, Jennifer Bellon, Huong T. Le-Petross, Anthony Lucci, Gildy Babiera, Sarah M. DeSnyder, Mediget Teshome, Edward Chang, B Tags: Research Report Source Type: research

Genetic Variants Within MTORC1 Genes Predict Gastric Cancer Prognosis in Chinese Populations
Conclusions: Our findings indicated that genetic variants within mTORC1 genes may predict GC prognosis in Chinese populations. The results need to be validated in future studies with larger sample sizes. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wenji Xue, Mengyun Wang, Li Zhang, Jianchun Gu, Xueru Zhu, Yiwei Wang, Ruifen Wang, Lifeng Wang, Weiye Wang, Xue-Feng Wang, Jia-Wei Mei, Leizhen Zheng, Mei-Ling Zhu Tags: Research Paper Source Type: research

The Efficacy and Toxicity of Gefitinib in Treating Non-small Cell Lung Cancer: A Meta-analysis of 19 Randomized Clinical Trials
Conclusion: Gefitinib might be more efficient than chemotherapy, but less efficient than other targeted therapies in ORR, especially in EGFR mutation-positive patients. Gefitinib can decrease the odds of hematologic toxicity compared to controls. Future studies, especially those with EGFR mutation-positive patients, will be needed to confirm our findings. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hongmei Wo, Jing He, Yang Zhao, Hao Yu, Feng Chen, Honggang Yi Tags: Research Paper Source Type: research

Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study
Background: When compared with patients harboring stage IIB and stage IIC disease, those with stage IIIA colorectal cancer have a better prognosis. We aimed to compare the cause-specific survival (CSS) of the patients with stage IIA rectal cancer with that of the patients with stage IIIA rectal cancer.Methods: Data analyzed about patients with stage IIA and stage IIIA rectal cancer was from the US Surveillance, Epidemiology, and End Results (SEER) database. We then validated the results using data derived from Fudan University Shanghai Cancer Center (FUSCC).Results: A total of 16,788 patients (13,551 staged IIA and 3,237 s...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shaobo Mo, Weixing Dai, Wenqiang Xiang, Ben Huang, Yaqi Li, Yang Feng, Qingguo Li, Guoxiang Cai Tags: Research Paper Source Type: research

EGFR Target Therapy Combined with Gemox for Advanced Biliary Tract Cancers: a Meta-analysis based on RCTs
Background: Controversy exists regarding whether EGFR-targeted therapy combined with GEMOX (gemcitabine and oxaliplatin) provides additional benefits over GEMOX alone for biliary tract cancer patients. Therefore, this meta-analysis of randomized controlled trials (RCTs) was performed to assess the efficacy and safety of the GEMOX + EGFR-targeted regimen, and subgroup analysis was conducted to identify groups that might benefit from targeted therapy.Methods: The PubMed, Cochrane Library, and ClinicalTrials.gov registries were searched for published studies. Hazard ratios (HRs) for progression-free survival (PFS) and overall...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wen Cai, Ying Yuan, Weiting Ge, Yu Fan, Xue Liu, Dehao Wu, Hanguang Hu Tags: Research Paper Source Type: research

Cancer Stem Cells are Regulated by STAT3 Signalling in Wilms Tumour
In this study, CD133+ cells were successfully isolated from a single-cell suspension of the G401 Wilms tumour cell line using magnetic activated cell sorting (MACS). Signal transducers and activators of transcription 3 (STAT3) has been implicated in tumorigenesis, but its contribution to the metastatic progression of WCSCs has not been investigated. Here, we show that STAT3 is overexpressed in WCSCs. Activation of STAT3 in WCSCs initiated a forward feedback loop that was responsible for mediating the aggressive malignant character of Wilms tumour cells in vitro and in vivo. Treatment of CD133+ cells with stattic, a STAT3 i...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yanmei Liu, Xuexiang Gao, Shuo Wang, Xuemin Yuan, Yunqing pang, Jian Chen, Jing Wang Tags: Research Paper Source Type: research

Shared liver-like transcriptional characteristics in liver metastases and corresponding primary colorectal tumors
This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma.Methods: Among the genes up-regulated in normal liver tissues versus normal colorectal tissues, we identified “liver-specific” genes whose expression levels ranked among the bottom 10% (“unexpressed”) of all measured genes in both normal colorectal tissues and primary colorectal tumors without metastasis. These liver-specific genes were investigated for their expressions in both the primary tumors and the corresponding liver metastases of seven primary C...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jun Cheng, Xuekun Song, Lu Ao, Rou Chen, Meirong Chi, You Guo, Jiahui Zhang, Hongdong Li, Wenyuan Zhao, Zheng Guo, Xianlong Wang Tags: Research Paper Source Type: research

The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis
The main purpose of this study was to perform a meta-analysis to assess the interaction between smoking and nine genes (GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, SULT1A1, hOGG1, XRCC1 and p53) on colorectal cancer, gastric cancer, liver cancer and oesophageal cancer. Published articles from the PubMed, ISI and EMBASE databases were retrieved. A total of 67 case-control studies or nested case-control studies were identified for the analysis. The pooled jodds ratio (OR) with 95% confidence interval (CI) was calculated using the random effect model. The overall study showed that the GSTM1 polymorphism was associated with the risk of...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Le Du, Lei Lei, Xiaojuan Zhao, Hongjuan He, Erfei Chen, Jing Dong, Yuan Zeng, Jin Yang Tags: Research Paper Source Type: research

Expression of Minichromosome Maintenance Proteins (MCM) and Cancer Prognosis: A meta-analysis
Minichromosome maintenance proteins (MCM) played a critical role in replication and cell cycle progression. However, their prognostic roles in cancer remain controversial. Therefore, we performed a meta-analysis to investigate the prognostic value of MCMs in cancers. Totally 31 eligible articles with 7653 cancer patients were included in this meta-analysis. We evaluated the relationship between MCMs expression and overall survival (OS) in various cancer patients by using pooled hazard ratios (HRs) and risk ratios (RRs) with 95% confidence intervals (CIs). The meta-analysis showed that carriers with high expression of MCM5 ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Kaihua Gou, Jingwei Liu, Xue Feng, Hao Li, Yuan Yuan, Chengzhong Xing Tags: Research Paper Source Type: research

Anticancer Properties of Fenofibrate: A Repurposing Use
Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little toxicity, fenofibrate is a drug of the fibrate class that plays an important role in lowering the levels of serum cholesterol and triglycerides while elevating the levels of high-density lipoproteins. Recently, several studies have implied that fenofibrate may exert anticancer effects via a variety of pathways in...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xin Lian, Gang Wang, Honglan Zhou, Zongyu Zheng, Yaowen Fu, Lu Cai Tags: Review Source Type: research

Serum VEGF levels in the early diagnosis and severity assessment of non-small cell lung cancer
This study explored the use of the serum vascular endothelial growth factor (VEGF) levels as a biomarker with the aim of achieving better management of NSCLC.Methods: Serum VEGF levels were assayed via enzyme-linked immunosorbent assay in 180 patients with NSCLC, 136 patients with benign pulmonary nodules, and 119 healthy controls. We additionally detected the serum concentration of three traditional biomarkers—carcinoembryonic antigen (CEA), cancer antigen (CA)-125, and cytokeratin 19 fragments (Cyfra 21-1)—to comparatively evaluate the efficiency and diagnostic value of VEGF in patients with NSCLC. We further...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yanzhen Lai, Xueping Wang, Tao Zeng, Shan Xing, Shuqin Dai, Junye Wang, Shulin Chen, Xiaohui Li, Ying Xie, Yuanying Zhu, Wanli Liu Tags: Research Paper Source Type: research

The Emerging Role of Circular RNAs in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene expression at transcription or post-transcription levels. Recent studies demonstrate that some circRNAs are differentially expressed in HCC, and the deregulation of these circRNAs is associated with the clinical pathological and prognostic significance. They also play essential roles in HCC progression, and contribute to cell proliferation, migration, invasion and metastasis by targeting di...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Li-Peng Qiu, Yi-Hang Wu, Xiao-Feng Yu, Qi Tang, Liang Chen, Ke-Ping Chen Tags: Review Source Type: research

Hepatitis B Virus Infection Predicts Better Survival In Patients With Colorectal Liver-only Metastases Undergoing Liver Resection
Conclusions: HBV-infected CRLM patients survived longer than non-infected patients. In clinical work, therapeutic regimens and follow-up for HBsAg-positive patients may be different from that for HBsAg-negative patients, even though objective prospective studies are still needed. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yujie Zhao, Junzhong Lin, Jianhong Peng, Yuxiang Deng, Ruixia Zhao, Qiaoqi Sui, Zhenhai Lu, Desen Wan, Zhizhong Pan Tags: Research Paper Source Type: research