Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between genetic variants in three telomere length-related genes and PCa risk in a case-control study. The influence of these variants on the leukocyte telomere lengths was then appraised by real-time PCR. RTEL1 rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, P = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) wer...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Cheng-Yuan Gu, Sheng-Ming Jin, Xiao-Jian Qin, Yao Zhu, Dai Bo, Guo-Wen Lin, Guo-Hai Shi, Ding-Wei Ye Tags: Research Paper Source Type: research

Clinical Implications of Tumor-Infiltrating Immune Cells in Breast Cancer
This study is focused on investigating the clinical implications of TIICs in breast cancer patients. We performed several in silico analyses of gene expression profiles in 2976 nonmetastatic tumor samples. CIBERSORT was used to estimate the proportion of 22 immune cell types to analyze their correlation with overall survival (OS) and disease-free survival (DFS) in different breast cancer subtypes and stages. Our results showed that a higher fraction of plasma cells in estrogen receptor (ER)-positive breast cancer patients indicated an increase in DFS (hazard ratio [HR]=0.66, 95% confidence interval [CI] 0.54~0.82, p
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Shi-Chao Zhang, Zu-Quan Hu, Jin-Hua Long, Gui-Ming Zhu, Yun Wang, Yi Jia, Jing Zhou, Yan Ouyang, Zhu Zeng Tags: Research Paper Source Type: research

Capecitabine plus Oxaliplatin as a Second-Line Therapy for Advanced Biliary Tract Cancers: A Multicenter, Open-Label, Phase II Trial
Conclusion: This phase II trial showed that XELOX treatment was efficacious and had a tolerable toxicity profile in patients with advanced BTC who failed first-line treatment of gemcitabine and cisplatin. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Seung Tae Kim, Sung Yong Oh, Jeeyun Lee, Jung Hun Kang, Hyun Woo Lee, Myung Ah Lee, Byeong Seok Sohn, Ji Hyong Hong, Young Suk Park, Joon Oh Park, Ho Yeong Lim Tags: Research Paper Source Type: research

The clinicopathological characteristic associations of long non-coding RNA gene H19 polymorphisms with uterine cervical cancer
The purposes of the current study were conducted to explore the relationships among long non-coding RNA gene H19 (LncRNA H19) polymorphisms and clinicopathological characteristics of uterine cervical cancer, and patient prognosis in Taiwan. Five genetic variants of LncRNA H19 rs3024270, rs2839698, rs3741219, rs2107425 and rs217727 were recruited from one hundred and thirty-four patients with invasive cancer, 101 with high-grade cervical intraepithelial neoplasia (CIN) of uterine cervix and 325 controls and their genetic distributions were determined. It indicated no associations of these LncRNA H19 genetic variants with de...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ming-Chao Huang, Ying-Hsiang Chou, Huang-Pin Shen, Soo-Cheen Ng, Yueh ‐ Chun Lee, Yi-Hung Sun, Chun-Fang Hsu, Shun-Fa Yang, Po-Hui Wang Tags: Research Paper Source Type: research

Mortalin stabilizes CD151-depedent tetraspanin-enriched microdomains and implicates in the progression of hepatocellular carcinoma
Conclusions: Mortalin maybe stabilize of the structure of CD151-dependent tetraspanin-enriched microdomains and implicate in the progression of HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Li-Xin Liu, Jia-Cheng Lu, Hai-Ying Zeng, Jia-Bin Cai, Peng-Fei Zhang, Xiao-Jun Guo, Xiao-Yong Huang, Rui-Zhao Dong, Chi Zhang, Qiang Kang, Hao Zou, Xin-Yu Zhang, Lu Zhang, Xiao-Wen Zhang, Ai-Wu Ke, Guo-Ming Shi Tags: Research Paper Source Type: research

p53/PCDH17/Beclin-1 Proteins as Prognostic Predictors for Urinary Bladder Cancer
Conclusions: Use of a DNA sequencing method to detect p53 gene mutations was consistent with an immunohistochemical method to detect p53 alterations. In conjunction with levels of p53/PCDH17/Beclin-1, p53 and PCDH17 were independently associated with prognosis; Beclin-1 only had a tendency towards overall survival. p53/PCDH17/Beclin-1 phenotype seems to play a more important role than p53 expression in bladder cancer outcome. It is also identified that p53/PCDH17, p53/Beclin-1 or PCDH17/Beclin-1 all have a cooperative and synergistic effect, which may provide us the potential biomarker for bladder cancer patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Liuxi Chen, Ying Liu, Qi Zhang, Mingming Zhang, Xuemeng Han, Qiujie Li, Tian Xie, Qibiao Wu, Xinbing Sui Tags: Research Paper Source Type: research

The role of hypofractionated radiotherapy for the definitive treatment of localized prostate cancer: early results of a randomized trial
Conclusions: Hypofractionated radiotherapy appears to be equally tolerated compared to conventional fractionation in the early setting. Longer follow up is needed to assess the late toxicity profile of the patients and any potential differences between the control and experimental arm. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Petros Alexidis, Dimitris Dragoumis, Sotirios Karatzoglou, Konstantinos Drevelegas, Ioannis Tzitzikas, Konstantinos Hatzimouratidis, Ioannis Chrisogonidis, Dimitris Giannakidis, Charilaos Koulouris, Athanasios Katsaounis, Nikolaos Michalopoulos, Haidong H Tags: Research Paper Source Type: research

Effects of Postoperative Radiotherapy in Early Breast Cancer Patients Older than 75 Years: A Propensity-Matched Analysis
Conclusions: PRT may benefit for elderly women with early breast cancer, especially in HR+ patients or white patients. These findings may inform future optimized options whether elderly female patients with early breast cancer should undergo postoperative radiotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Linghui Zhou, Pengtao Yang, Yi Zheng, Tian Tian, Cong Dai, Meng Wang, Shuai Lin, Yujiao Deng, Qian Hao, Zhen Zhai, Hongtao Li, Zhijun Dai Tags: Research Paper Source Type: research

Efficacy and Safety of Intro-Arterial Chemotherapy Combined with Radiotherapy on Head and Neck Cancer: A Systematic Review and Meta-Analysis
Objectives: Intro-arterial chemotherapy combined with radiotherapy (IACRT) for the treatment of head and neck cancer (HNC) underwent a revival in recent years. Although many clinical trials have reported favorable outcomes, the effect of IACRT for HNC is still controversial. Therefore, this study was designed to evaluate the efficacy and safety of IACRT for HNC.Methods: The relevant articles published before August 2019 were searched from PubMed, Embase, Cochrane Library, Web of Science and PMC databases. Data were extracted and the combined complete response (CR), overall survival (OS) and toxicity incidence with 95% cred...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yan Huang, Li-Ling Wu, Ruo-Lan Xiang, Guang-Yan Yu Tags: Research Paper Source Type: research

Cumulative Score Based on Preoperative Fibrinogen and Pre-albumin Could Predict Long-term Survival for Patients with Resectable Gastric Cancer
Background: To investigate the prognostic significance of the cumulative score based on preoperative fibrinogen and pre-albumin (FP score) in patients with gastric cancer after radical gastrectomy.Methods: Baseline characteristics, preoperative fibrinogen and pre-albumin levels were retrospectively reviewed in patients who underwent radical gastrectomy. The optimal cut-off values for fibrinogen and pre-albumin were defined as 4.0 g/L and 230.0 mg/L, respectively. Patients with elevated fibrinogen (≥ 4.0 g/L) and decreased pre-albumin (
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zhi-jun Wu, Hui Xu, Rong Wang, Li-jia Bu, Jie Ning, Ji-qing Hao, Guo-ping Sun, Tai Ma Tags: Research Paper Source Type: research

High expression of PDE4D correlates with poor prognosis and clinical progression in pancreaticductal adenocarcinoma
Conclusions: Our study reveals that PDE4D up-regulated in PDAC was closely associated with poor prognosis of PDAC patients and multiple aggressive clinicopathological characteristics. PDE4D could be a useful prognostic biomarker and therapeutic target for PDAC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Fude Liu, Jieyi Ma, Kebing Wang, Zhi Li, Qingping Jiang, Hui Chen, Wen Li, Jintang Xia Tags: Research Paper Source Type: research

Immune-Checkpoint Inhibitors as the First Line Treatment of Advanced Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials
Conclusions: Our meta-analysis showed the superiority of combination therapy over monotherapy with chemotherapeutic agents in terms of tumor response, and long-term survival, but with an increased the 3 - 5 grade toxicity. And immune-checkpoint inhibitors alone showed similar tumor response, toxicity and long-term outcomes compared to platinum-based chemotherapy in selected patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yuqiao Chen, Yuan Zhou, Lu Tang, Xiong Peng, Hong Jiang, Guo Wang, Wei Zhuang Tags: Review Source Type: research

GV1001 inhibits cell viability and induces apoptosis in castration-resistant prostate cancer cells through the AKT/NF- κ B/VEGF pathway
Conclusions: Our data demonstrated that GV1001 inhibited cell viability, induced apoptosis, and inhibited angiogenesis in CRPC cells by inhibition of the AKT/NF-κB/VEGF signaling pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yong Hyun Park, Ae Ryang Jung, Ga Eun Kim, Mee Young Kim, Jae Woo Sung, Dongho Shin, Hyuk Jin Cho, U-Syn Ha, Sung-Hoo Hong, Sae Woong Kim, Ji Youl Lee Tags: Research Paper Source Type: research

RUFY3 Predicts Poor Prognosis and Promotes Metastasis through Epithelial-mesenchymal Transition in Lung Adenocarcinoma
Conclusions: Our study is first to demonstrated that abnormal expression of RUFY3 indicates poor prognosis in lung adenocarcinoma and also indicates that RUFY3 may be related to EMT process. This highlights the potential of RUFY3 as a novel prognostic biomarker for lung adenocarcinoma. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Wanfu Men, Wenya Li, Yu Li, Jungang Zhao, Xiaohan Qu, Peiwen Li, Shulei Gong Tags: Research Paper Source Type: research

Galectin-1 Promotes Vasculogenic Mimicry in Gastric Cancer by Upregulating EMT Signaling
Conclusion: Our results indicated that Gal-1 promotes VM in GC by upregulating EMT signaling; thus, Gal-1 and this pathway are potential novel targets to treat VM in GC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiaolan You, Qinghong Liu, Jian Wu, Yuanjie Wang, Jiawen Dai, Dehu Chen, Yan Zhou, Yanjun Lian Tags: Research Paper Source Type: research

Genome-wide analysis to identify a novel microRNA signature that predicts survival in patients with stomach adenocarcinoma
Objective: Using genome-wide screening, this study was aimed at identifying prognostic microRNA (miRNA) in those patients suffering from stomach adenocarcinoma (STAD).Methods: A genome-wide miRNA sequencing dataset and relevant STAD clinical information was obtained via The Cancer Genome Atlas (TCGA). Prognostic miRNA selection was carried out through a whole genome multivariate Cox regression model in order to establish a prognostic STAD signature.Results: Eleven miRNAs (hsa-mir-509-2, hsa-mir-3917, hsa-mir-495, hsa-mir-653, hsa-mir-3605, hsa-mir-2115, hsa-mir-1292, hsa-mir-137, hsa-mir-6511b-1, hsa-mir-145, and hsa-mir-1...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Shan-Shan Luo, Xi-Wen Liao, Xiao-Dong Zhu Tags: Research Paper Source Type: research

Natural History of Pediatric Low-Grade Glioma Disease - First Multi-State Model Analysis
Conclusion: In this first MSM analysis we delineated a refined description of PLGG disease course over time, identifying three levels of progressiveness. Growth behavior in the first two years predicted future progressiveness and death. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Anna-Maria Goebel, Astrid K. Gnekow, Daniela Kandels, Olaf Witt, Rene Schmidt, Pablo Hern á iz Driever Tags: Research Paper Source Type: research

Molecular Mechanisms and Anticancer Therapeutic Strategies in Vasculogenic Mimicry
Vasculogenic mimicry (VM) is a vascular formation mechanism used by aggressive tumor cells. VM provides an alternative pathway for adequate blood perfusion and challenges the traditional angiogenesis mechanism that depends only on endothelial cells (ECs), as VM-forming tumor cells express a mixed endothelial/tumor phenotype. VM is closely correlated with tumor invasion, migration, and progression. Hence, anticancer therapeutic strategies targeting VM biogenesis are essential. It is widely acknowledged that the VM formation mechanism involves multiple pathways. The purpose of this review is to describe the potential molecul...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xue Zhang, Jigang Zhang, Heming Zhou, Guorong Fan, Qin Li Tags: Review Source Type: research

Downregulation of RAI14 inhibits the proliferation and invasion of breast cancer cells
Retinoic acid-induced 14 (RAI14) is involved in the development of different tumor types, however, its expression and biological function in breast cancer are yet unknown. In the current study, we demonstrated that RAI14 was highly expressed in breast cancer. The high expression of RAI14 is positively correlated with the malignant progression of breast cancer and suggests a worse prognosis. Further, we found that knockdown RAI14 inhibits the proliferation, migration and invasion of breast cancer cells by regulating cell cycle and EMT through Akt/Cyclin D1, MMP2, MMP9 and ZEB1/E-cadhrin/Vimentin pathway. These findings reve...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ming Gu, Wenhui Zheng, Mingdi Zhang, Xiaoshen Dong, Yan Zhao, Shuo Wang, Haiyang Jiang, Lu Liu, Xinyu Zheng Tags: Research Paper Source Type: research

Impact of tumour size on metastasis and survival in patients with pancreatic neuroendocrine tumours (PNETs): A population based study
Background: The relationship between tumour size and metastasis rate is poorly recognized in patients with pancreatic neuroendocrine tumours (PNETs). The impact of tumour size on prognosis was controversial in previous investigations.Methods: PNETs cases diagnosed from 1988 to 2013 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Clinicopathologic features were retrospectively analyzed. Survival was calculated by the Kaplan-Meier method. Multivariable Cox regression models with hazard ratios (HRs) were constructed to analyze survival outcomes and risk factors. Cubic spline analysis was u...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yangyang Liu, Shufang Ye, Yabi Zhu, Xingkang He, Jie Pan, Shujie Chen, Bin Ye, Liangjing Wang Tags: Research Paper Source Type: research

H19 gene polymorphisms and neuroblastoma susceptibility in Chinese children: a six-center case-control study
Neuroblastoma is the most common seen solid tumor in children less than one year old. Given that polymorphisms in the lncRNA H19 gene are observed in several types of human malignancies, there likely to be similar events that contribute to the pathogenesis of neuroblastoma. We hypothesize that single nucleotide polymorphisms (SNPs) in the H19 gene might predispose to neuroblastoma. Here, we genotyped three SNPs (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) from H19 gene in a Chinese population (700 subjects with neuroblastoma and 1516 control subjects) enrolled from six hospitals and examined the effect of individu...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yong Li, Zhen-Jian Zhuo, Haiyan Zhou, Jiabin Liu, Jiao Zhang, Jiwen Cheng, Haixia Zhou, Suhong Li, Ming Li, Jun He, Zhenghui Xiao, Jing He, Yaling Xiao Tags: Research Paper Source Type: research

MTBHsp70-exFPR1-pulsed Dendritic Cells Enhance the Immune Response against Cervical Cancer
In this study, we developed a novel immunotherapeutic peptide by linking the Mycobacterium tuberculosis (MTB) heat shock protein 70 (Hsp70) functional peptide to the extracellular domain of FPR1, a protein overexpressed in cervical cancer, to obtain an MTBHsp70-exFPR1 fusion protein. Our experiments confirmed that the MTBHsp70-exFPR1 protein could promote DC maturation and induce the secretion of IL-12p70, IL-1β, and TNF-α. The antitumor effect of human cytotoxic T lymphocytes (CTLs) activated by autologous DCs was assessed in NOG mice. These results indicate that DCs pulsed with MTBHsp70-exFPR1 can enhance anti...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Guangming Cao, Ran Cui, Chongdong Liu, Guyu Zhang, Zhenyu Zhang Tags: Research Paper Source Type: research

CLEC4M is associated with poor prognosis and promotes cisplatin resistance in NSCLC patients
This study mainly focused on whether CLEC4M impacts clinical prognosis and how CLEC4M contributes to cisplatin resistance in NSCLC. Our results found that CLEC4M was correlated with poor prognosis in patients with lung cancer. In addition, a positive association between CLEC4M expression and the IC50 values of cisplatin was found, which suggests that CLEC4M may impact cisplatin sensitivity. In vitro results from cultured A549 and H1299 cells confirmed that CLEC4M could enhance cisplatin resistance, while CLEC4M knockdown led to higher sensitivity to cisplatin in these cells. Further experiments showed that the underlying m...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Li-Ming Tan, Xi Li, Cheng-Feng Qiu, Tao Zhu, Cheng-Ping Hu, Ji-Ye Yin, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu Tags: Research Paper Source Type: research

The screening of pivotal gene expression signatures and biomarkers in renal carcinoma
This study aims to explore potential signaling pathways and key biomarkers that drive RCC progression. The RCC GEO Datasets GSE15641 was featured to screen differentially expressed genes (DEGs). The pathway enrichment and functional annotation of differentially expressed genes were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the Gene Ontology (GO). We screened Hub genes from DEGs using protein-protein interaction (PPI) networks and Cytoscape software. The survival and diagnostic analysis of these hub genes was performed to evaluate their potential prognostic and diagnostic value for ccRCC. In GSE1...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Hailong Ruan, Sen Li, Junwei Tong, Qi Cao, Zhengshuai Song, Keshan Wang, Yu huang, Lin Bao, Xuanyu Chen, Hongmei Yang, Ke Chen, Xiaoping Zhang Tags: Research Paper Source Type: research

Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells
Protein kinase D (PKD) has been implicated in cancer cell survival, proliferation, migration and angiogenesis. However, it is still unknown whether PKD regulates cell proliferation through lipid metabolism in cancer cells. Here we report a novel function of PKD3, a member of PKD family, in regulating of prostate cancer cell proliferation by modulation of SREBP1-mediated de novo lipogenesis. We show that silencing of PKD3 significantly reduces lipid content and expression of the lipogenic genes encoding FASN and ATP-citrate lyase (ACLY). Moreover, endogenous PKD3 interacts with sterol regulatory element binding protein 1(SR...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ling Li, Liang Hua, Huihui Fan, Yu He, Wanfu Xu, Lin Zhang, Jie Yang, Fan Deng, Fangyin Zeng Tags: Research Paper Source Type: research

Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer
In this study, we report a novel lncRNA, LINC00467, which was significantly up-regulated in CRC; we investigated its function and mechanism in CRC. Our study demonstrated that LINC00467 levels in 45 pairs of CRC tissues were higher than those in the corresponding normal colon mucosal tissues. We used the Gene Expression Omnibus (GEO) and Gene Expression Profiling Interactive Analysis (GEPIA) databases for the analysis and measurement of clinical samples, and observed that the CRC patients with high LINC00467 expression levels showed poor overall survival (OS) and recurrent-free survival (RFS) rates. Furthermore, following ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiaoyun He, Shen Li, Bingbing Yu, Gaoyan Kuang, Yongrong Wu, Meili Zhang, Yuxiang He, Chunlin Ou, Pengfei Cao Tags: Research Paper Source Type: research

Long Intergenic Noncoding RNA 00261 Acts as a Tumor Suppressor in Non-Small Cell Lung Cancer via Regulating miR-105/FHL1 Axis
Conclusions: These results indicate that LINC00261 could suppress metastasis and proliferation of NSCLC via suppressing miR-105/FHL1 axis, which may offer a new vision for interpreting the mechanism of NSCLC development. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zhiqiang Wang, Jiru Zhang, Bo Yang, Runsheng Li, Linfang Jin, Zhenjun Wang, Haifeng Yu, Chuanxin Liu, Yong Mao, Qingjun You Tags: Research Paper Source Type: research

Double-edged role of radiotherapy in patients with pulmonary large-cell neuroendocrine carcinoma
This study was performed to evaluate the effect of surgery and radiotherapy on patients with LCNEC.Materials and Methods: We analyzed 1,619 patients with stage I-III LCNEC, identified from the Surveillance, Epidemiology, and End Results database, diagnosed from 2000 to 2013. The Kaplan-Meier analysis and the Cox proportional hazard model were used to study patient prognosis.Results: Overall, 869 (53.7%) stage I LCNEC patients, 203 (12.5%) stage II patients, and 547 (33.8%) stage III patients were included in the analysis. Various surgery types were all associated with higher overall survival (OS) and lung cancer-specific s...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yuanzhu Jiang, Cong Lei, Xufeng Zhang, Yangang Cui, Keying Che, Hongchang Shen Tags: Research Paper Source Type: research

Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway
In this study, we found liensinine can significantly inhibit gastric cancer cell proliferation in vitro and in vivo. Liensinine inducedgastric cancer cell apoptosis by increasing cleaved PARP, caspased 3 and caspased 9. Moreover, liensinine induced cycle arrest by downregulatingcyclinD1/cyclin‑dependent kinase4 and phosphorylated protein kinase B. Furthermore, we found liensinine increases ROS levels and inhibits the PI3K/AKT pathway. These data suggested that liensinine might represent a novel and effective agent against gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jia-hua Yang, Kun Yu, Xian-ke Si, Sen Li, Yi-jun Cao, Wei Li, Ji-xun Zhang Tags: Research Paper Source Type: research

Jiedu Sangen Decoction Reverses Epithelial-to-mesenchymal Transition and Inhibits Invasion and Metastasis of Colon Cancer via AKT/GSK-3 β Signaling Pathway
Conclusion: JSD reverses EMT and inhibits invasion and metastasis of colon cancer through the AKT/GSK-3β signaling pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Li Yuan, Kai Zhang, Meng-Meng Zhou, Harpreet S. Wasan, Fang-Fang Tao, Qing-Ying Yan, Guan Feng, Yin-Shan Tang, Min-He Shen, Sheng-Lin Ma, Shan-Ming Ruan Tags: Research Paper Source Type: research

Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis
Gene methylation is an epigenetic alteration in hepatocellular carcinoma (HCC), and hepatitis B virus (HBV) plays a crucial role in carcinogenesis of HCC. However, the association between gene methylation and HBV infection in HCC remains unclear. In our study, we conducted a comprehensive meta-analysis to evaluate the association. A total of 1,148 studies were initially retrieved from some literature database. After a four-step filtration, we obtained 69 case-control studies in this meta-analysis. Our results showed six genes (p16, RASSF1A, GSTP1, APC, p15 and SFRP1) in HBV-positive carcinoma tissues, one gene (GSTP1) in H...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Cheng Zhang, Changxin Huang, Xinbing Sui, Xueqing Zhong, Wenjun Yang, Xiangrong Hu, Yongqiang Li Tags: Research Paper Source Type: research

Establishment and characterization of novel human primary endometrial cancer cell line (ZJB-ENC1) and its genomic characteristic
In conclusion, this new stable cell line may promote basic and clinical research on endometrial cancer (EC). (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiaozhen Liu, Zhuozhuo Ren, Yu Xu, Wei Sun, Yongfeng Li, Xinmiao Rui, Dafei Xie, Xuli Meng, Zhiguo Zheng Tags: Research Paper Source Type: research

Hypoglycemia as a Symptom of Neoplastic Disease, with a focus on Insulin-like Growth Factors Producing Tumors
This article reviews the current knowledge of uncommon causes of hypoglycemia, with a focus on neoplastic disease. However, these situations are rare. They commonly accompany severely ill patients and therefore a proper diagnosis is the basis for relevant treatment. Here we discuss the pathophysiological foundation of hypoglycemia - situations caused by increased insulin production or sensitivity - but we also focus on different cytokines which could cause hypoglycemia, especially IGF-II production in what are called nonislet cell tumors. From the clinical perspective we can divide the patients who are affected into "...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jan Schovanek, Lubica Cibickova, Filip Ctvrtlik, Zbynek Tudos, David Karasek, Maurizio Iacobone, Zdenek Frysak Tags: Review Source Type: research

LOX inhibition downregulates MMP-2 and MMP-9 in gastric cancer tissues and cells
The objective of this study was to analyze the effects of lysyl oxidase (LOX) on the expression and enzyme activity of the matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) and to study its preliminary effect mechanisms.Methods: We collected fresh cancer specimens from 49 gastric cancer patients who underwent surgery. Immunohistochemistry was used to quantitate the protein expression levels of LOX and MMP-9 in gastric cancer tissues and to analyze their correlation. Also, six-week old nude mice were divided into a control group and a LOX inhibition group. SGC-7901 gastric cancer cells were inoculated subcutaneously into th...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Lei Zhao, Haiya Niu, Yutao Liu, Lei Wang, Ning Zhang, Gaiqiang Zhang, Rongqing Liu, Mei Han Tags: Research Paper Source Type: research

Research on Current Curative Expenditure among Lung Cancer Patients Based on the “ System of Health Accounts 2011 ” : Insights into Influencing Factors
Purpose: To investigate the total current curative expenditure (CCE) of lung cancer in Hunan Province, China under the framework of the System of Health Accounts 2011 (SHA 2011) and explore the effect of insurance status, surgery and length of stay on the hospitalization expenses of patients with lung cancer.Methods: Through multistage stratified cluster random sampling, a total of 46,214 patients with lung cancer were enrolled from 1,072 medical institutions in Hunan Province in 2016. Under the SHA 2011 framework, the lung cancer CCE was analyzed. The relationships between hospitalization expenditure and the following fac...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Shuang Zang, Huan Zhan, Liangrong Zhou, Xin Wang Tags: Research Paper Source Type: research

Knockdown of long non-coding RNA PCAT-1 inhibits myeloma cell growth and drug resistance via p38 and JNK MAPK pathways
Conclusion: This study identified a novel lncRNA-associated mechanism underlying MM carcinogenesis, and provided clinicians with a promising therapeutic target in MM. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xianjuan Shen, Pei Shen, Qian Yang, Qingqing Yin, Feng Wang, Hui Cong, Xudong Wang, Shaoqing Ju Tags: Research Paper Source Type: research

IL-6 Promotes Cancer Stemness and Oncogenicity in U2OS and MG-63 Osteosarcoma Cells by Upregulating the OPN-STAT3 Pathway
This study aimed to investigate the role of IL-6 in modulating clinicopathological features, malignant traits, and stemness in osteosarcoma, and to determine the mechanisms underlying IL-6-mediated osteosarcoma progression. Methods: Patients with osteosarcoma (n = 54) and healthy controls (n = 50) were selected. No patients received any pre-operative cancer treatment. Serum levels of IL-6 were determined in patients with osteosarcoma by ELISA and their relationship with pathological features and prognosis analyzed. The 3-(4,5-dimethyl -2-thiazolyl)- 2,5-diphenyl-2H-tetrazolium bromide (MTT) and colony formation assays were...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chuan Zhang, Kun Ma, Wu-Yin Li Tags: Research Paper Source Type: research

Bioinformatics analysis of differentially expressed genes in hepatocellular carcinoma cells exposed to Swertiamarin
Conclusion: Swertiamarin treatment led to significant changes in the expression of a variety of genes that modulate cell survival, cell cycle progression, apoptosis, and invasion. Moreover, most of these genes can be clustered into pathway networks such as PI3K, JUN, STAT3, which are predicted targets of swertiamarin. Further confirmation of these targets will reveal the anti-tumor mechanisms of swertiamarin and facilitate the development of swertiamarin as a novel agent for cancer prevention and treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Haoran Tang, Yang Ke, Zongfang Ren, Xuefen Lei, Shufeng Xiao, Tianhao Bao, Zhitian Shi, Renchao Zou, Tiangen Wu, Jian Zhou, Chang-An Geng, Lin Wang, Jijun Chen Tags: Research Paper Source Type: research

A new prediction model for prognosis of patients with intermediate-stage HCC after conventional transarterial chemoembolization: an internally validated study
This study aimed to develop a new survival prediction model to help select patients who would benefit better from cTACE treatment.Methods: We collected data of 848 treatment-naïve patients with BCLC B HCC who received cTACE as first-line therapy. The prognostic model's variables were derived from univariate and multivariate Cox regression analyses. The concordance index (C-statistic) calculated through cross-validation and bootstrap resampling was used for the model selection. The calibration of our final prediction model was also assessed.Results: The model showed a better discrimination ability than Bolondi's BCLC B...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Rong-Xin Chen, Yu-Hong Gan, Ning-Ling Ge, Yi Chen, Min Ma, Bo-Heng Zhang, Yan-Hong Wang, Sheng-Long Ye, Jian-Feng Luo, Zheng-Gang Ren Tags: Research Paper Source Type: research

Synergistic inhibition of lung cancer cells by EGCG and NF- κ B inhibitor BAY11-7082
Lung cancer has a poor 5-year survival rate and is the leading cause of cancer-related deaths worldwide. Thus, the development of more efficient therapeutic strategies is urgently needed. Many studies have shown that EGCG, a major polyphenol found in green tea, has potential anticancer effects. The present study aims to investigate the molecular mechanism of EGCG-mediated inhibition of proliferation in lung cancer cells and to explore the effects of combined treatment with EGCG and an NF-κB inhibitor, BAY11-7082, in A549 and H1299 cells both in vitro and in vivo. Our results showed that EGCG inhibits cell proliferati...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Lingyu Zhang, Jing Xie, Ruihuan Gan, Zhangwei Wu, Huatian Luo, Xingyong Chen, Youguang Lu, Lixian Wu, Dali Zheng Tags: Research Paper Source Type: research

The synergic inhibitory effects of dark tea (Camellia sinensis) extract and p38 inhibition on the growth of pancreatic cancer cells
Conclusion: Based on the sequential extraction procedure, our results reveal the inhibitory effect of water eluate fraction of the ethyl acetate extract from dark tea and its synergistic effect with p38 inhibition on the growth of pancreatic cancer cells, in which ID1 is identified as a downstream effector. This sheds insights into the physiological relevance of specific fraction of dark tea to tumorigenesis in pancreatic cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ke Zheng, Qin Zhao, Qing Chen, Weiqun Xiao, Yuedeng Jiang, Yuhui Jiang Tags: Research Paper Source Type: research

Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF- β /cPML signalling promotes leukemia cell invasion
In this study, we identified the EMT-related gene versican (VCAN) in NPM1-mutated AML across three patient datasets. Further experiments validated the elevated VCAN expression in NPM1-mutated AML primary blasts and OCI-AML3 cells with NPM1 mutation. Mechanistic studies revealed that increased VCAN expression was at least partially regulated by NPM1 mutant via TGF-β/cPML/Smad signalling. Functional evaluations showed that silencing VCAN by shRNA significantly suppressed cell migration and invasion capacity, whereas increased VCAN by overexpressing NPM1-mA enhanced migration and invasion ability of leukemia cells. Final...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Liyuan Yang, Lu Wang, Zailin Yang, Hongjun Jin, Qin Zou, Qian Zhan, Yuting Tang, Yao Tao, Li Lei, Yipei Jing, Xueke Jiang, Ling Zhang Tags: Research Paper Source Type: research

Prognostic value of ABO blood group in a Chinese population in Northwest China region with curatively resected rectal cancer
A positive association between the ABO blood types and survival has been suggested in several malignancies. However, little is known about the relationship between ABO blood group and survival in rectal cancer patients. The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of a Chinese population in Northwest China region with curatively resected rectal cancer. We retrospectively analyzed 1613 consecutive patients who underwent curative surgery for rectal cancer between June, 2011 and December, 2016. The relationship between the ABO blood types and overall survival (OS) was analyze...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jiangpeng Wei, Ying Zhang, Jianyong Zheng, Xiangying Feng, Xiaomin Wang, Kunli Du, Weizhong Wang, Guosheng Wu, Qingchuan Zhao, Daiming Fan, Xiaohua Li Tags: Research Paper Source Type: research

Accuracy of Magnetic Resonance Imaging in Staging Rectal Cancer with Multidisciplinary Team: A Single-Center Experience
Conclusions: In conclusion, MDT discussion increased the accuracy of MRI in preoperative staging diagnosis for rectal cancer. This mode could give a more accurate clinical stage of patients, which was in favor of choosing a preferable therapy strategy. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Linzhen Yu, Liuhong Wang, Yinuo Tan, Hanguang Hu, Li Shen, Shu Zheng, Kefeng Ding, Suzhan Zhang, Ying Yuan Tags: Research Paper Source Type: research

The mRNA Expression Signature and Prognostic Analysis of Multiple Fatty Acid Metabolic Enzymes in Clear Cell Renal Cell Carcinoma
Renal cell carcinoma (RCC) is a metabolic disease, and accumulating evidences indicate significant alterations in the cellular metabolism, especial aerobic glycolysis and glutamine metabolism, in RCC. However, fatty acid (FA) metabolism has received less attention, and the mRNA expression pattern and prognostic role of FA metabolic enzymes in clear cell RCC (ccRCC) have not been carefully examined. In the current study, we first investigated the mRNA expression profiles of multiple FA metabolic enzymes, i.e., ACLY, ACC, FASN, SCD, CPT1A, HADHA, HADHB, and ACAT1, in 42 ccRCC and 33 normal kidney tissues using the Oncomine d...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zuohui Zhao, Yueran Liu, Qiang Liu, Fei Wu, Xiaoli Liu, Hongyi Qu, Yijiao Yuan, Juntao Ge, Yue Xu, Hao Wang Tags: Research Paper Source Type: research

Latest Overview of the Cyclin-Dependent Kinases 4/6 Inhibitors in Breast Cancer: The Past, the Present and the Future
Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Administration and the European Medicines Agency for the treatment of advanced and metastatic HR+/HER2- breast cancer. However, no consistent conclusion has been reached to its application in other types of breast cancer. Therefore, the purpose of our study was to overview the clinical trials about the beneficial ef...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiu Chen, Di Xu, Xingjiang Li, Jian Zhang, Weilin Xu, Junchen Hou, Wei Zhang, Jinhai Tang Tags: Review Source Type: research

Significant prognostic values of differentially expressed-aberrantly methylated hub genes in breast cancer
This study aimed to identify differentially expressed hub genes which may be regulated by DNA methylation and evaluate their prognostic value in breast cancer by bioinformatic analysis.Methods: GEO2R was used to obtain expression microarray data from GSE54002, GSE65194 and methylation microarray data from GSE20713, GSE32393. Differentially expressed-aberrantly methylated genes were identified by FunRich. Biological function and pathway enrichment analysis were conducted by DAVID. PPI network was constructed by STRING and hub genes was sorted by Cytoscape. Expression and DNA methylation of hub genes was validated by UALCAN ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Lina Qi, Biting Zhou, Jiani Chen, Wangxiong Hu, Rui Bai, Chenyang Ye, Xingyue Weng, Shu Zheng Tags: Research Paper Source Type: research

Integrin β 4 promotes invasion and anoikis resistance of papillary thyroid carcinoma and is consistently overexpressed in lymphovascular tumor thrombus
Although the majority of papillary thyroid cancers (PTC) are indolent, a subset of PTCs behaves aggressively due to extensive invasion and distant metastasis. Integrin β4, a member of the integrin family, has been shown to enhance the progression in some malignancies; however, its role in PTC remains unclear. Here, we demonstrated that β4 overexpression was associated with extrathyroid extension, lymph node metastasis, high TNM stage, and poor overall survival based on The Cancer Genome Atlas cohort. Immunohistochemistry showed that β4 expression was significantly upregulated in the tumors with infiltrating ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jian Li, Minghua Luo, Huiting Ou, Xiaoling Liu, Xueling Kang, Weihua Yin Tags: Research Paper Source Type: research

LncRNA MALAT1 acts as a miR-125a-3p sponge to regulate FOXM1 expression and promote hepatocellular carcinoma progression
Conclusions: These results indicate that MALAT1 modulates FOXM1 expression via being a miR-125a-3p sponge, thus promoting HCC progression. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Shihai Liu, Jing Qiu, Guifang He, Ye Liang, Liping Wang, Changchang Liu, Huazheng Pan Tags: Research Paper Source Type: research

Radiographic Features of Metastatic Brain Tumors from ALK-rearranged Non-small Cell Lung Cancer: Implications for Optimal Treatment Modalities
Conclusions: Both WBRT and SRS are appropriate for the treatment of BM in patients with ALK-rearranged NSCLC. The incidence of BM in the hippocampus and peri-hippocampus region is low in our radiological data. Nearly 80% of patients with metachronous BM have oligo-metastatic lesions, indicating that SRS is the preferred therapy while PCI is not indicated. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Li Chu, Jianjiao Ni, Xi Yang, Tong Tong, Jialei Wang, Fang Yin, Ruimin Li, Yida Li, Liqing Zou, Yuan Li, Congying Xie, Guodong Li, Zhengfei Zhu Tags: Research Paper Source Type: research