Sex Disparities in the Clinical Characteristics, Synchronous Distant Metastasis Occurrence and Prognosis: A Pan-cancer Analysis
Conclusion: Male gender appears to be an independent risk factor associated with the occurrence and prognosis of synchronous distant metastasis. Therefore, sex-specific preventions and treatments should become the focus of future research. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yutong Wang, Ziqian Zeng, Mingshuang Tang, Min Zhang, Ye Bai, Huijie Cui, Yao Xu, Xu Guo, Wenjuan Ma, Guijun Xu, Lisha Qi, Jingyi Wang, Siyu Chen, Dongqing Gu, Min Mao, Xin Wang, Chao Zhang Tags: Research Paper Source Type: research
Preoperative Denosumab may increase the Risk of Local Recurrence of Giant-cell Tumor of Bone Treated with Curettage: A Systematic Review and Meta-analysis
Conclusions: Preoperative denosumab may increase the risk of local recurrence of GCTB treated with curettage and should be used with caution in the management of GCTB. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yongzhao Zhao, Zhenyu Cai, Xiaodong Tang, Zhiye Du, Yi Yang, Wei Guo Tags: Research Paper Source Type: research
High mobility group box 1 regulates gastric cancer cell proliferation and migration via RAGE-mTOR/ERK feedback loop
Gastric cancer (GC) is a common malignancy tumour in China. Despite various therapeutic approaches to improve the survival rate of GC patients, the effectiveness of currently available treatments remains unsatisfactory. High mobility group box 1 (HMGB1) is reported to play a role in tumour development. However, the molecular mechanisms involved in HMGB1-mediated regulation of proliferation and migration of GC cells remain unclear. In the present study, we demonstrated that HMGB1 is highly expressed in GC cells and tissue. In HGC-27 GC cells, HMGB1 overexpression or HMGB1 RNA interference both demonstrated that HMGB1 could ...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Tuo Tang, Shengnan Wang, Tianyu Cai, Zhenyu Cheng, Yu Meng, Shimei Qi, Yao Zhang, Zhilin Qi Tags: Research Paper Source Type: research
LncRNA LOXL1-AS1 promotes esophageal squamous cell carcinoma progression by targeting DESC1
Recently, ample evidence indicated that numerous aberrantly expressed long non-coding RNAs (lncRNAs) participated in the development of multiple malignancies. However, the expression and function of lncRNA LOXL1-AS1 in mediating esophageal squamous cell carcinoma (ESCC) carcinogenesis remains largely elusive. Here we validated that LOXL1-AS1 was significantly upregulated in ESCC tissues compared with the corresponding adjacent non-neoplastic tissues, and LOXL1-AS1 expression was positively correlated with ESCC patients' lymph node metastasis. Besides, LOXL1-AS1 knockdown impaired ESCC cells proliferation, migration and inv...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Hongle Li, Jie Chu, Jinlin Jia, Jinxiu Sheng, Xue Zhao, Yurong Xing, Fucheng He Tags: Research Paper Source Type: research
Can Patients with Pancreatic Cancer and Liver Metastases Obtain Survival Benefit from Surgery? A Population-Based Study
Conclusions: Surgical procedures for both primary site and other sites improved survival. SPL, particularly, showed a considerable survival benefit in well-selected patients with PCL. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Bing-Bing Su, Dou-Sheng Bai, Jiang-Quan Yu, Chi Zhang, Sheng-Jie Jin, Bao-Huan Zhou, Guo-Qing Jiang Tags: Research Paper Source Type: research
Minimal Residual Disease and Survival Outcomes in Patients with Mantle Cell Lymphoma: a systematic review and meta-analysis
Conclusions: This study indicated that MRD positivity after induction and consolidation treatments was associated with worse PFS and OS for MCL. MRD-based treatment strategies should be further explored in clinical trials and real-world practice. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yu Zhou, Haizhu Chen, Yunxia Tao, Qiaofeng Zhong, Yuankai Shi Tags: Research Paper Source Type: research
18F-FDG PET/CT Scans Can Identify Sub-Groups of NSCLC Patients with High Glucose Uptake in the Majority of Their Tumor Lesions
Conclusions: 18F-FDG PET/CT scans can identify sub-groups of NSCLC patients with high glucose uptake in the majority of their tumor lesions. T2DM patients had higher tumor lesion glucose uptake than non-diabetic patients. However, this was not independent of other factors such as the histological subtype and number of tumor lesions per patient. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Anne M. Hendriks, Adrienne H. Brouwers, Panagiotis Giannopoulos, Joop D. Lefrandt, Wim Timens, Harry J.M. Groen, Geertruida H. de Bock, Mathilde Jalving Tags: Research Paper Source Type: research
Regulation and biological functions of the CX3CL1-CX3CR1 axis and its relevance in solid cancer: A mini-review
CX3CL1 is a transmembrane protein from which a soluble form can be generated by proteolytic shedding. Membranal and soluble forms of CX3CL1 exhibit different functions, although both bind to the CX3CR1 chemokine receptor. The CX3CL1-CX3CR1 axis mediates the adhesion of leukocytes and is also involved in cell survival and recruitment of immune cell subpopulations. The function of CX3CL1 is finely tuned by cytokines and transcription factors regulating its expression and post-translational modifications. On homeostasis, the CX3CL1-CX3CR1 axis participates in the removal of damaged neurons and neurogenesis, and it is also inv...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Selma Rivas-Fuentes, Alfonso Salgado-Aguayo, Jenny Arratia-Quijada, Patricia Gorocica-Rosete Tags: Review Source Type: research
Predictive value of tumor mutation burden (TMB) with targeted next-generation sequencing in immunocheckpoint inhibitors for non-small cell lung cancer (NSCLC)
Conclusions: TMB is a promising biomarker, which can predict the efficacy of ICI therapy in advanced NSCLC patients, included ORR, DCR, PFS and OS. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xiaoting Ma, Yujian Zhang, Shan Wang, Jing Yu Tags: Research Paper Source Type: research
Immunological Role and Prognostic Value of APBB1IP in Pan-Cancer Analysis
Conclusion: APBB1IP can serve as a prognostic biomarker in pan-cancer analysis. APBB1IP upregulation was correlated with increased immune-cell infiltration, and the expression APBB1IP in different tumors might be related to the tumor immune microenvironment. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Qianyun Ge, Ganxun Li, Jin Chen, Jia Song, Guangzhen Cai, Yi he, Xuewu Zhang, Huifang Liang, Zeyang Ding, Bixiang Zhang Tags: Research Paper Source Type: research
Circular PVT1 regulates cell proliferation and invasion via miR-149-5p/FOXM1 axis in ovarian cancer
In conclusion, circular PVT1 increased FOXM1 level via binding to miR-149-5p and thus affected ovarian cancer cell viability and migration. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Min Li, Chi Chi, Liqin Zhou, Youguo Chen, Xiuwu Tang Tags: Research Paper Source Type: research
Ethanol Extracted from Radix of Actinidia Chinensis Inhibits Human Colon Tumor Through Inhibiting Notch-signaling Pathway
Conclusions: EERAC might be a promising chemotherapeutic agent for CRC treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Wanle Hu, Chenchen Wu, Chenchen Yuan, Minyuan Chen, Chun Jin, Chenguo Zheng Tags: Research Paper Source Type: research
The oncogenic and prognostic role of PDK1 in the progression and metastasis of ovarian cancer
Ovarian cancer (OC) is the most lethal of gynecological tumors in women. Tumor metabolism has become a new opportunity in the treatment of tumors. Pyruvate dehydrogenase kinase 1 (PDK1), as a key regulatory enzyme implicated in metabolic reprogramming of tumors, abnormally high expressed in various tumors and involved in the regulation of tumor cell biological behavior. However, the role of PDK1 in the occurrence and development of ovarian cancer remains unclear. Our team identified the expression of PDK1 in ovarian cancer cell lines and tissues through RT-PCR and immunohistochemical staining and evaluated the correlation ...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Shasha Yao, Wenwen Shang, Lei Huang, Rui Xu, Ming Wu, Fang Wang Tags: Research Paper Source Type: research
Genomic and clinical characteristics of MET exon14 alterations in a large cohort of Chinese cancer patients revealed distinct features and a novel resistance mechanism for crizotinib
Conclusion: Chinese cancer patients have a relatively lower frequency of METex14 alterations compared to Western patients. Patients with METex14 alterations showed distinct molecular characteristics and the representative case study showed responses to MET tyrosine kinase inhibitor (TKI). (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Tianli Cheng, Zhongping Gu, Danni Song, Sisi Liu, Xiaoling Tong, Xue Wu, Zhifeng Lin, Wei Hong Tags: Research Paper Source Type: research
A Double-Edged Sword: The Anti-Cancer Effects of Emodin by Inhibiting the Redox-Protective Protein MTH1 and Augmenting ROS in NSCLC
Conclusions: Based on our data, the anti-cancer effects of emodin as an MTH1 inhibitor have clinical potential as a single agent capable of functioning as a ROS inducer and simultaneous blocker of dNTP pool sanitation in the treatment of NSCL cancers. Collectively, our results have identified for the first time that the potential molecular mechanism of emodin function, increasing DNA damage and apoptosis in cancer cells, is via MTH1 inhibition. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Divya Wahi, Deepika Soni, Abhinav Grover Tags: Research Paper Source Type: research
