Interventional radiofrequency ablation: A promising therapeutic modality in the management of malignant biliary and pancreatic duct obstruction
Conclusion: The percutaneous endoluminal RF based ablation of obstructed duct with metallic stent placement appeared to be a safe, effective procedure and may improve survival in patients with advanced stage cancer presenting with biliary and PD obstruction. Considering the above mentioned evidence, this modality may stand ahead of stenting alone. This could be considered as viable modality in management of such patients where very limited treatment options are available. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: M Mizandari, J Kumar, M Pai, T Chikovani, T Azrumelashvili, I Reccia, N Habib Tags: Research Paper Source Type: research

Human salivary microRNAs in Cancer
Circulating microRNAs (miRNAs) have emerged as excellent candidates for cancer biomarkers. Several recent studies have highlighted the potential use of saliva for the identification of miRNAs as novel biomarkers, which represents a great opportunity to improve diagnosis and monitor general health and disease. This review summarises the mechanisms of miRNAs deregulation in cancer, the value of targeting them with a therapeutic intention and the evidence of the potential clinical use of miRNAs expressed in saliva for the detection of different cancer types. We also provide a comprehensive review of the different methods for ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ó scar Rapado-Gonz á lez, Blanca Majem, Laura Muinelo-Romay, Ana Á lvarez-Castro, Anna Santamar í a, Antonio Gil-Moreno, Rafael L ó pez-L ó pez, Mar í a Mercedes Su á rez-Cunqueiro Tags: Review Source Type: research

High Expression of P38 α and Preoperative Carbohydrate Antigen 19-9 Indicate Poor Prognosis in Patients with Pancreatic Ductal Adenocarcinoma
Background: P38α is a ubiquitous protein kinase, which plays diverse roles in cancers. Surprisingly, P38α functions vary markedly in different cancers (e.g., cancer suppressor vs cancer promoter). However, there is no report on the expression of P38α, the family's most important member, in pancreatic ductal adenocarcinoma (PDAC) and its association with clinicoathological parameters and patients' prognosis.Materials and methods: We retrospectively analyzed 152 patients who underwent surgery and were pathologically diagnosed with PDAC from September 2013 to September 2015. We used immunohistochemistry to d...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jionghuang Chen, Ting Zhao, Shengnan Jia, Senhao Zhou, Liangjing Zhou, Shaowen Wang, Guoping Ding, Guixing Jiang, Liping Cao Tags: Research Paper Source Type: research

Lymph node staging systems in patients with gastric cancer treated with D2 resection plus adjuvant chemotherapy
Conclusion: The lymph node ratio-based staging scheme performs the best for the prediction of survival in patients with locally advanced gastric cancer treated with D2 resection followed by adjuvant chemotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yi-Xin Zhou, Lu-Ping Yang, Zi-Xian Wang, Ming-Ming He, Jing-Ping Yun, Dong-Sheng Zhang, Feng Wang, Rui-Hua Xu Tags: Research Paper Source Type: research

mTOR signaling-related MicroRNAs and Cancer involvement
MicroRNAs (miRNAs) are a class of single-stranded RNAs, 18-23 nucleotides in length that regulate gene expression at the post-transcriptional level. Dysregulation of miRNAs has been closely associated with the development of cancer. In the process of tumorigenesis, mammalian target of rapamycin (mTOR) plays important roles, and the mTOR signaling pathway is aberrant in various types of human cancers, including non-small cell lung cancer (NSCLC), breast cancer, prostate cancer, as well as others. However, the relationship between miRNAs and the mTOR signaling pathway is indistinct. Herein, we not only summarize the progress...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ping WANG, Xiao-min LIU, Lei DING, Xin-ju ZHANG, Zhong-liang MA Tags: Review Source Type: research

An arginine-rich cell penetrating peptide contained anti-gelatinase scFv-LDM fusion protein shows potent antitumor efficacy in pancreatic cancer
This study was to evaluate the antitumor activities of dFv-LDP-AE and dFv-R-LDP-AE, two energized fusion protein targeting gelatinases, on pancreatic cancer. The fusion protein dFv-LDP-AE consists of two tandem anti-gelatianses scFv and an enediyne antibiotic lidamycin (LDM) for receptor binding and cell killing. To improve the penetration capability, the fusion protein dFv-LDP-AE was integrated with an arginine-rich cell penetrating peptide (Arg)9 and then generated the fusion protein dFv-R-LDP-AE. The current study demonstrated that dFv-LDP and dFv-R-LDP had high affinity with the antigen gelatinases and PC cells, the in...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Genshen Zhong, Zhishan Xu, Ru Yang, Shenghua Zhang, Liang Li, Minna Wu, Hongtao Liu, Yongsu Zhen Tags: Research Paper Source Type: research

Clinical and Diagnostic Significance of Homer1 in hepatitis B virus-induced Hepatocellular Carcinoma
Conclusion: Our data highlighted that Homer1 played a critical role in HCC tumorigenesis and might be a potential diagnostic marker for HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ping Luo, Xiaobo Feng, Wei Jing, Man Zhu, Nandi Li, Hu Zhou, paul F worley, Hongyan Chai, Jiancheng Tu Tags: Research Paper Source Type: research

Efficacy and safety of different interventions in castration resistant prostate cancer progressing after docetaxel-based chemotherapy: Bayesian network analysis of randomized controlled trials
Conclusions: Our results demonstrated that Abiraterone Acetate might be the optimal intervention for CRPC patients after docetaxel failure with acceptable tolerability. Future well-designed RCTs and systematic reviews are needed to validate these findings. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yue Zhao, Hao Huang, Changhao Chen, Hao Liu, Hongwei Liu, Feng Su, Junming Bi, Thomas B. Lam, Jiaping Li, Tianxin Lin, Jian Huang Tags: Research Paper Source Type: research

Apolipoprotein A-I Is a Prognosticator of Nasopharyngeal Carcinoma in the Era of Intensity-modulated Radiotherapy
This study aimed to evaluate the clinical value of pretreatment serum lipid profiles in predicting clinical outcome of NPC.Methodology / Principal Findings: A total of 1927 consecutive patients who had untreated NPC and completed radical IMRT between Jan. 2010 and Dec. 2011 were retrospectively reviewed. Pretreatment serum lipid indexes including total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-I (apoAI) and apolipoprotein B were analyzed for their association with survivals, together with the clinical features (age, sex, pathological type, anemia,...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hui Chang, Jia-wang Wei, Kai Chen, Shu Zhang, Fei Han, Li-xia Lu, Wei-wei Xiao, Yuan-hong Gao Tags: Research Paper Source Type: research

Overcoming chemoresistance in pancreatic cancer cells: role of the bitter taste receptor T2R10
In conclusion, T2R10 is expressed in pancreatic cancer and it downmodulates the chemoresistance of the tumor cells. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Louisa Stern, Nathalia Giese, Thilo Hackert, Oliver Strobel, Peter Schirmacher, Klaus Felix, Matthias M. Gaida Tags: Research Paper Source Type: research

GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study
Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conducted a prospective study to evaluate the associations between functional SNPs and risk of RP.Methods: We recruited a total of 149 lung cancer patients who had received intensity modulated radiation therapy (IMRT). GSTP1 and XRCC1 were genotyped using the SurPlexTM-xTAG method in all patients. RP events were pro...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Lehui Du, Wei Yu, Xiang Huang, Nana Zhao, Fang Liu, Fang tong, Sujing Zhang, Baolong Niu, Xiaoliang Liu, Shouping Xu, Yurong Huang, Xiangkun Dai, Chuanbin Xie, Gaoxiang Chen, Xiaohu Cong, Baolin Qu Tags: Research Paper Source Type: research

Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression
In conclusion, our study demonstrated that niclosamide could inhibit the growth of NPC cells and sensitize the NPC cells to radiation via suppressing the transcription of Ku70/80. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jingjing Li, Haiwen Li, Dechao Zhan, Mei Xiang, Jun Yang, Yufang Zuo, Yin Yu, Hechao Zhou, Danxian Jiang, Haiqing Luo, Zihong Chen, Zhonghua Yu, Zumin Xu Tags: Research Paper Source Type: research

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer
Ribosomal protein L10 (RPL10) is one of large ribosomal proteins and plays a role in Wilms' tumor and premature ovarian failure. However, the function of RPL10 in human epithelial ovarian cancer (EOC) remains unknown. The purpose of this study was to examine the expression level and function of RPL10 in EOC. RPL10 protein expression was detected by immunohistochemistry and Western blot. The association RPL10 expression with clinical features was analyzed. Loss-of-function and gain-of-function approaches were applied in cellular assays, including cell viability, migration, invasion, and apoptosis. Our study demonstrated for...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu Tags: Research Paper Source Type: research

Upregulation of HES1 Promotes Cell Proliferation and Invasion in Breast Cancer as a Prognosis Marker and Therapy Target via the AKT Pathway and EMT Process
In this study, we assessed HES1 expression in breast cancer tissues using immunohistochemistry and Western blot analyses and investigated HES1 function using MTT and Matrigel invasion assays. Significant relationships were observed between HES1 upregulation and advanced TNM stage (p=0.011), node metastasis (p=0.043), negative oestrogen receptor expression (p=0.001) and triple-negative status (p=0.001). HES1 overexpression was correlated with poor prognosis in breast cancer patients (p
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiaoying Li, Yu Cao, Mu Li, Feng Jin Tags: Research Paper Source Type: research

Exosomes in Nasopharyngeal Carcinoma
Exosomes are nanosized (30-100nm) membrane microvesicles secreted through a complex cellular process. Exosomes contain a variety of bioactive molecules, such as proteins, microRNAs(miRNAs or miRs) and long non-coding RNAs (lncRNAs), playing an important role in the cell-to-cell substance transportation and signal transduction. Nasopharyngeal carcinoma-related exosomes (NPC-Exo) have been identified in circulating blood and contribute to tumor cell proliferation, angiopoiesis, and immune tolerance through remodeling of tumor microenvironment (TME). Nasopharyngeal carcinoma-related exosomes may also induce epithelial-mesench...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yujuan Zhou, Longzheng Xia, Jingguan Lin, Heran Wang, Linda Oyang, Shiming Tan, Yutong Tian, Min Su, Hui Wang, Deliang Cao, Qianjin Liao Tags: Review Source Type: research

FOXG1 Expression Is Elevated in Glioma and Inhibits Glioma Cell Apoptosis
FOXG1, a member of forkhead family transcriptional factor, is involved in telencephalon development. Recent studies showed FOXG1 was important for a variety of cellular events in cancer cells. In respect to glioma, FOXG1 has been shown to regulate cell proliferation and cell cycles. However, its impacts on other cellular events were not well studied. Here, we found FOXG1 had high expression in clinical glioma tissues, and its expression positively correlated with glioma malignancy. Moreover, we found FOXG1 played roles in glioma cell apoptosis. The expressions of caspase family members were significantly altered in respons...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jingying Chen, Xinmin Wu, Zhenkai Xing, Chi Ma, Wencheng Xiong, Xiaojuan Zhu, Xiaoxiao He Tags: Short Research Communication Source Type: research

The Optimal Application of Transrectal Ultrasound in Staging of Rectal Cancer Following Neoadjuvant Therapy: A Pragmatic Study for Accuracy Investigation
This study is designed to explore their relationship and confirm an optimal application of TRUS in rectal cancer restaging.Methods: From 2005 to 2011, rectal cancer patients with TRUS data were retrospectively reviewed. Patients were divided into five groups according to tumor-involved rectal segment (SEG) above the anal verge: SEG I 1-3cm, II 3-6cm, III 6-9cm, IV 9-12cm, and V 12-16cm. The accuracy and long-term outcomes of tumor staging were compared between ultrasonographic and pathological stages.Results: 219 patients were included, with 55 (25.1%) in SEG I, 123 (56.2%) in SEG II, 32 (14.6%) in SEG III, 4 (1.8%) in SEG...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yufeng Ren, Jinning Ye, Yan Wang, Weixin Xiong, Jianbo Xu, Yulong He, Shirong Cai, Min Tan, Yujie Yuan Tags: Research Paper Source Type: research

Serum expression level of IL-6 at the diagnosis time contributes to the long-term prognosis of SCLC patients
In this study, we concluded 707 non-operable SCLC patients at stage III or IV into this study and analyzed the relationships between interleukins and OS/PFS by cox regression analysis and Kaplan-Meier analysis (log-rank test). As a result, under current standard chemotherapy, SCLC patients with higher IL-6 expression level had a shortened OS compared with those with normal level (HR: 0.381, 95%CI: 0.177-0.822, p=0.014). Furthermore, IL-6 expression level contributed mostly to patients without a smoking history. Non-smoking patients with a high IL-6 level showed a 6 months shortened OS than those with normal IL-6 level (10....
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xi Ding, Jie Zhang, Di Liu, Wen Xu, De-yi Lu, Li-Ping Zhang, Bo Su Tags: Research Paper Source Type: research

A Prognostic Score for Nasopharyngeal Carcinoma with Bone Metastasis: Development and Validation from Multicenter
Background: To establish a prognostic score based on clinical routine factors to stratify nasopharyngeal carcinoma patients with bone metastasis into risk groups with different survival rates.Materials and Methods: Total 276 patients from multicenter were retrospectively analyzed. Kaplan-Meier method and Cox regression were used to confirm independent risk factors, which were checked for internal validity by bootstrapping method. The prognostic score, deriving from the corresponding regression coefficients in Cox model, classified patients into low and high risk groups. Finally, two independent cohorts were used for extern...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chen Chen, Jing-Bo Wu, Hao Jiang, Jin Gao, Jia-Xin Chen, Chang-Chuan Pan, Lu-Jun Shen, Yu Chen, Hui Chang, Ya-Lan Tao, Xiao-Hui Li, Pei-Hong Wu, Yun-Fei Xia Tags: Research Paper Source Type: research

The value of preoperative Glasgow Prognostic Score and the C-Reactive Protein to Albumin Ratio as prognostic factors for long-term survival in pathological T1N0 esophageal squamous cell carcinoma
Plenty of studies have confirmed the prognostic values of inflammation-based prognostic scores in many malignant tumors. In present study, we aim to explore whether these indexes has same prognostic values in patients with stage T1N0 esophageal squamous cell carcinoma (ESCC). The clinicopathological data of 160 consecutive patients with pathological stage T1N0 ESCC from January 2005 to December 2012 were collected retrospectively. As prognostic factors, the inflammation-based prognostic scores, including C-reactive protein (CRP), Glasgow prognostic score (GPS), prognostic index (PI), neutrophil to lymphocyte ratio (NLR), p...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiangyang Yu, Yingsheng Wen, Yongbin Lin, Xuewen Zhang, Yongqiang Chen, Weidong Wang, Gongming Wang, Lanjun Zhang Tags: Research Paper Source Type: research

A New and Safe Mode of Ventilation for Interventional Pulmonary Medicine: The Ease of Nasal Superimposed High Frequency Jet Ventilation
We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in diagnostic pulmonary medicine. The method of sedation and ventilation is very important in order to avoid or handle with success complications. Proper respiration during pulmonary (or other interventional) procedures is a key factor. Apart from the proper sedation method we have to choose the proper ventilation...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Haidong Huang, Yan-Gao Man, Stella Laskou, Charilaos Koulouris, Dimitris Giannakidis, Stylianos Mantalobas, Maria C. Florou, Aikaterini Amaniti, Michael Steinheimer, Anil Sinha, Lutz Freitag, J Francis Turne Tags: Research Paper Source Type: research

Discrimination between malignant and benign mass-like lesions from breast dynamic contrast enhanced MRI: semi-automatic vs. manual analysis of the signal time-intensity curves
Conclusion: With respect to the analysis of TIC from breast DCE-MRI, the results demonstrated that the new method increased the diagnostic accuracy, and should be considered as a supplementary tool for distinguishing benign and malignant lesions. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jiandong Yin, Jiawen Yang, Zejun Jiang Tags: Research Paper Source Type: research

Ring finger protein 38 promote non-small cell lung cancer progression by endowing cell EMT phenotype
Conclusions: Our results indicate that elevated expression of RNF38 is significantly associated with the proliferation and metastatic capacity of NSCLC cells, and RNF38 overexpression can serve as a biomarker of NSCLC poor prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Dian Xiong, Shu-Qiang Zhu, Yong-Bing Wu, Chun Jin, Jia-Hao Jiang, Yun-Fei Liao, Xiang Long, Hai-Bo Wu, Jian-Jun Xu, Ji-Jun Li, Jian-Yong Ding Tags: Research Paper Source Type: research

Cancer survival in patients from a hospital-based cancer registry, China
Purpose: There are few reports on survival rate analysis from hospital-based cancer registries (HBCR) in China, although the National Center of Cancer Registry of China has launched such an effort with the mission to expand the scope of registration and follow-up. Our study aimed to evaluate survival and outcomes of cancer patients from a HBCR in eastern China.Methods: Active and passive follow-up methods were used to obtain information on survival status for all patients from Qidong City and Haimen City in the databases of our hospital-based registrations from 2002 to 2014. Censor time for survival was 31st March, 2016. S...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jian-Guo Chen, Hai-Zhen Chen, Jian Zhu, Yan-Lei Yang, Yong-Hui Zhang, Pei-Xin Huang, Yong-Sheng Chen, Chao-Yong Zhu, Li-Ping Yang, Kang Shen, Fu-Lin Qiang, Gao-Ren Wang Tags: Research Paper Source Type: research

The value of neutrophil-to-lymphocyte ratio for response and prognostic effect of neoadjuvant chemotherapy in solid tumors: A systematic review and meta-analysis
Conclusion: Overall, an NLR lower than the cut-off value indicated a greater chance for pCR and may predict good survival outcomes after NAC for patients with solid tumours. The use of the NLR for risk stratification before NAC should be further demonstrated by future large-scale prospective studies. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xuan Li, Danian Dai, Bo Chen, Hailin Tang, Xiaoming Xie, Weidong Wei Tags: Research Paper Source Type: research

Overall survival and post-progression survival are potent endpoint in phase III trials of second/third-line chemotherapy for advanced or recurrent epithelial ovarian cancer
Conclusions: Our findings indicate that PPS is highly associated with OS in second/third-line chemotherapy for advanced or recurrent epithelial ovarian cancer, while the association between PFS and OS is moderate. We recommend using OS as primary endpoint for clinical trial of ovarian cancer, however PFS is still an optional endpoint. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Mototsugu Shimokawa, Takahiro Kogawa, Takako Shimada, Toshiaki Saito, Hozumi Kumagai, Masafumi Ohki, Tsunehisa Kaku Tags: Research Paper Source Type: research

Large Intergenic Non-coding RNA-RoR Inhibits Aerobic Glycolysis of Glioblastoma Cells via Akt Pathway
Reprogramming energy metabolism is a hallmark of malignant tumors, including glioblastoma (GBM). Aerobic glycolysis is often utilized by tumor cells to maintain survival and proliferation. However, the underlying mechanisms of aerobic glycolysis in GBM remain elusive. Herein, we demonstrated that large intergenic non-coding RNA-RoR (LincRNA-RoR) functioned as a critical suppressor to inhibit the aerobic glycolysis and viability of GBM cells. We found that LincRNA-RoR was markedly reduced in GBM tissues compared with adjacent non-tumor tissues from 10 cases of GBM patients. Consistently, LincRNA-RoR expression in GBM cells ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yong Li, Zhi-Cheng He, Qing Liu, Kai Zhou, Yu Shi, Xiao-Hong Yao, Xia Zhang, Hsiang-Fu Kung, Yi-Fang Ping, Xiu-Wu Bian Tags: Research Paper Source Type: research

Inhibition of PI3K/AKT Signaling Pathway Radiosensitizes Pancreatic Cancer Cells with ARID1A Deficiency in Vitro
Pancreatic cancer is among the most aggressive human cancers, and is resistant to regular chemotherapy and radiotherapy. The AT-rich interactive domain containing protein 1A (ARID1A) gene, a crucial chromatin remodeling gene, mutates frequently in a broad spectrum of cancers, including pancreatic cancer. Recent evidence suggests that ARID1A acts as tumor suppressor and plays an important role in DNA damage repair (DDR). However, the effect of ARID1A on the radiosensitivity of pancreatic cancer remains unclear. Herein, we investigated the involvement of ARID1A depletion in the radioresistance of pancreatic cancer cells, and...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Lin Yang, Guanghai Yang, Yingjun Ding, Yuhong Dai, Sanpeng Xu, Qiuyun Guo, Aini Xie, Guangyuan Hu Tags: Research Paper Source Type: research

Characteristics and Treatment of Brain Metastases from Esophageal Squamous Cell Carcinoma
Brain metastasis is very rare in esophageal squamous cell carcinoma (ESCC). We retrospectively analyzed 4494 patients diagnosed with ESCC between 2010 and 2015 at a single institute; 15 of these patients developed brain metastases. All 15 patients had neurologic symptoms and were diagnosed by imaging or biology. Of the 15 patients, 67% had a solitary brain lesion and 73% had lesions larger than 3 cm. After treatment of the brain lesions, including surgery (53%) or stereotactic radiotherapy with or without whole brain radiation (20%), the median progression free survival time and the 2-year overall survival rate calculated ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qiaoqiao Li, Meiling Deng, Mian Xi, Yujia Zhu, Yonghong Hu Tags: Research Paper Source Type: research

Alteration of Serum IgG Galactosylation as a Potential Biomarker for Diagnosis of Neuroblastoma
Conclusions: The analysis of serum IgG galactosylation distribution may play a suggestive role for neuroblastoma diagnosis, or serve as a potential biomarker for NB diagnosis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wenjun Qin, Hao Pei, Ruihuan Qin, Ran Zhao, Jing Han, Zejian Zhang, Kuiran Dong, Shifang Ren, Jianxin Gu Tags: Research Paper Source Type: research

Targeting hepatocarcinogenesis model in C56BL6 mice with pan-aurora kinase inhibitor Danusertib
Conclusions: Depletion of AURK reduced the number of DEN-induced hepatic tumours. However, their size did not differ significantly between the groups. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Paschalis Gavriilidis, Theofilos Poutahidis, Alexander Giakoustidis, Kali Makedou, Katerina Angelopoulou, Alexander Hardas, Paola Andreani, Argyro Zacharioudaki, George Saridis, Athanasios Gargavanis, Eleni Louri, Nikolaos Antoniadis, Eleftheria Karampela Tags: Research Paper Source Type: research

Genome-wide Association Study (GWAS) of Germline Copy Number Variations (CNVs) Reveal Genetic Risks of Prostate Cancer in Chinese population
The objective of this study was to identify possible PCa-risk associated CNV regions in Chinese population.Materials and Methods: We performed a genome-wide association study for CNV in 1,417 PCa cases and 1,008 controls in Chinese population.Results: 7 risk-associated CNVs were identified for PCa after association analyses (P
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yishuo Wu, Haitao Chen, Guangliang Jiang, Zengnan Mo, Dingwei Ye, Meilin Wang, Jun Qi, Xiaoling Lin, S. Lilly Zheng, Ning Zhang, Rong Na, Qiang Ding, Jianfeng Xu, Yinghao Sun Tags: Research Paper Source Type: research

CXCR4/CXCR7/CXCL12-Axis in Follicular Thyroid Carcinoma
Conclusion: Here we provide first evidence of the biological importance of the CXCR4/CXCR7/CXCL12 axis in FTC. Our findings underscore the therapeutic potential of this chemokine receptor family in advanced FTC and offer new valuable insight into the oncogenesis of metastatic FTC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Thomas Artur Werner, Christina Maria Forster, Levent Dizdar, Pablo Emilio Verde, Katharina Raba, Matthias Schott, Wolfram Trudo Knoefel, Andreas Krieg Tags: Research Paper Source Type: research

Epigenetic modification of SALL1 as a novel biomarker for the prognosis of early stage head and neck cancer
This study examined Sal-like protein (SALL)1 methylation profiles in head and neck squamous-cell carcinoma (HNSCC) patients at diagnosis and follow-up, and evaluated their prognostic significance and value as a biomarker. SALL1 expression was examined in a panel of cell lines by quantitative reverse transcription PCR (qRT-PCR). Promoter methylation was determined by quantitative methylation-specific polymerase chain reaction (qMSP) and was compared to the clinical characteristics of 205 samples. SALL1 promoter methylation was associated with transcriptional inhibition and was correlated with disease recurrence in 31.7% of ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Kiyoshi Misawa, Yuki Misawa, Atsushi Imai, Daiki Mochizuki, Shiori Endo, Masato Mima, Ryuji Ishikawa, Hideya Kawasaki, Takashi Yamatodani, Takeharu Kanazawa Tags: Research Paper Source Type: research

Tumor location is an independent predictive factor for distant metastasis and metastatic sites of rectal adenocarcinoma in patients receiving total mesorectal excision
Background and Objectives: To evaluate the predictive factor for and patterns of distant metastasis in patients with rectal adenocarcinoma receiving total mesorectal excision (TME).Methods: We enrolled 217 consecutive patients who had histologically confirmed rectal adenocarcinoma and underwent surgery at Taipei Medical University- Wanfang Hospital between January 2000 and December 2014. TME was performed in all patients undergoing a sphincter-sparing procedure or abdominal perineal resection of rectal cancer. We performed univariate and multivariate Cox regression analyses of the distant metastasis rate in all patients to...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chien-Hsin Chen, Mao-Chih Hsieh, Ping-Kun Hsiao, En-Kwang Lin, Yen-Jung Lu, Szu-Yuan Wu Tags: Research Paper Source Type: research

Increased Paxillin expression in prostate cancer is associated with advanced pathological features, lymph node metastases and biochemical recurrence
This study analyzed the association between Paxillin expression in prostate cancer (PCa) tissues with clinicopathological features, lymph node metastasis and biochemical PCa recurrence.Methods A total of 386 tissue specimens from PCa patients who received radical prostatectomy and 60 tissue specimens from benign prostatic hyperplasia (BPH) cases were collected to construct tissue microarrays, which were subsequently immunostained for Paxillin expression. Thirty positive lymph node tissue specimens and 10 healthy prostate tissue specimens were randomly selected for Paxillin immunostaining.Results The association between Pax...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qing-Shui Zheng, Shao-Hao Chen, Yu-Peng Wu, Hui-Jun Chen, Hong Chen, Yong Wei, Xiao-Dong Li, Jin-Bei Huang, Xue-Yi Xue, Ning Xu Tags: Research Paper Source Type: research

Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma
A total of 200 smoking-related laryngeal carcinoma patients with pathology confirmation from the Eye and ENT Hospital and 190 high-risk smokers were included in a survey. All of the participants had a smoking index greater than 400 (cigarettes/day*year.) We obtained data on clinical and baseline characteristics, and peripheral blood was obtained and subjected to DNA extraction to analyse the correlation between smoking and the occurrence of laryngeal carcinoma. We selected candidate genes and SNP fragments that were found to be closely associated with smoking-related tumours in preliminary studies. The selected candidate g...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yi Zhu, Luo Guo, ShengZi Wang, Qun Yu, JianXiong Lu Tags: Research Paper Source Type: research

Prospective matched study on comparison of volumetric-modulated arc therapy and intensity-modulated radiotherapy for nasopharyngeal carcinoma: dosimetry, delivery efficiency and outcomes
Background: The purpose of this study is to assess the feasibility of volumetric-modulated arc therapy (VMAT) for nasopharyngeal carcinoma (NPC) patients by comparing the physical dosimetry, delivery efficiency and clinical outcomes with intensity-modulated radiotherapy (IMRT).Methods: A prospective matched study was performed for patients with newly diagnosed NPC who underwent VMAT or IMRT. The patients in two groups were equally matched in terms of gender, age, tumor stage and chemotherapy. The target coverage, homogeneity index (HI) and conformity index (CI) of the planning target volume (PTV), organs at risk (OARs) spa...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Bin-Bin Chen, Shao-Min Huang, Wei-Wei Xiao, Wen-Zhao Sun, Ming-Zhu Liu, Tai-Xiang Lu, Xiao-Wu Deng, Fei Han Tags: Research Paper Source Type: research

The anti-tumor effects of dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A on inducing autophagy in esophageal squamous cell carcinoma
The effect and regulation of autophagy-related proteins Beclin-1 and LC3 in esophageal squamous cell carcinoma have not been fully studied. The aim of this study was to assess the expression of Beclin-1 and LC3 in ESCCs, and to investigate the association between the two markers and clinicopathological characteristics as well as prognosis. Meanwhile, we explored the anti-tumor effect of the PI3K/mTOR dual inhibitor BEZ235 and the histone deacetylase inhibitor TSA on inducing autophagy in ESCC cells. Our study included 118 ESCC tumors and paired non-tumor esophageal mucosa tissues. Beclin-1 and LC3 expression were performed...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ning Wu, Yingfeng Zhu, Xiao Xu, Yongjun Zhu, Yang Song, Liewen Pang, Zhiming Chen Tags: Research Paper Source Type: research

IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma
Background. Recent studies have shown that isocitrate dehydrogenase 1/2 (IDH1/2)- activating mutations occur in a variety of cancers, including acute myeloid leukaemia, gliomas, and chondrosarcomas (CHS)s. The effect of IDH1/2 mutation on overall survival (OS) has not been reported in CHS. The aim of our study was to assess the prevalence of known cancer-related gene mutations in CHS, as well as their prognostic role in patient survival.Methods. DNA from FFPE samples of 80 patients (F:M- 1:1.3; mean age: 58 years; range 27-86) with histologically confirmed CHS (G1:29; G2:34; G3:17) was subjected to library preparation with...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Iwona Lugowska, Pawel Teterycz, Michal Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Michal Wagrodzki, Andrzej Pienkowski, Piotr Rutkowski, Jerzy Ostrowski Tags: Research Paper Source Type: research

Switch of the ovarian cancer cell to a calcifying phenotype in the calcification of ovarian cancer
Conclusion: Our study showed that the switch of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer. The calcified phenotypic transformation may inform the new prospective in ovarian cancer therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jirui Wen, Zhiwei Zhao, Liwei Huang, Liang Li, Jiman Li, Ye Zeng, Jiang Wu, Yali Miao Tags: Research Paper Source Type: research

LASS2 regulates invasion and chemoresistance via ERK/Drp1 modulated mitochondrial dynamics in bladder cancer cells
In conclusion, the present study demonstrated that LASS2 inhibits bladder cancer invasion and chemoresistance through regulation of ERK-Drp1 induced mitochondrial dynamics. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Lijuan Huang, Ting Luan, Yujin Chen, Xin Bao, Yinglong Huang, Shi Fu, Haifeng Wang, Jiansong Wang Tags: Research Paper Source Type: research

A Novel Risk prediction Model for Patients with Combined Hepatocellular-Cholangiocarcinoma
Backgrounds: Regarding the difficulty of CHC diagnosis and potential adverse outcomes or misuse of clinical therapies, an increasing number of patients have undergone liver transplantation, transcatheter arterial chemoembolization (TACE) or other treatments.Objective: To construct a convenient and reliable risk prediction model for identifying high-risk individuals with combined hepatocellular-cholangiocarcinoma (CHC).Methods: 3369 patients who underwent surgical resection for liver cancer at Zhongshan Hospital were enrolled in this study. The epidemiological and clinical characteristics of the patients were collected at t...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Meng-Xin Tian, Wen-Jun He, Wei-Ren Liu, Jia-Cheng Yin, Lei Jin, Zheng Tang, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Chen-Yang Tao, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Ying-Hong Shi Tags: Research Paper Source Type: research

Effect of the oncolytic ECHO-7 virus Rigvir ® on the viability of cell lines of human origin in vitro
Conclusions: The results suggest that Rigvir® in vitro reduces the viability of cells of human melanoma, rhabdomyosarcoma, gastric adenocarcinoma, lung carcinoma, pancreas adenocarcinoma but not in PBMC. The presence of Rigvir® in the sensitive cells was confirmed using anti-ECHO-7 antibodies. The present results suggest that a mechanism of action for the clinical benefit of Rigvir® is its cytolytic properties. The present results suggest that the effect of Rigvir® could be tested in other cancers besides melanoma. Further studies of possible Rigvir® entry receptors are needed. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Andra Tilgase, Liene Patetko, Ilze Bl ā ķ e, Anna Ramata ‑ Stunda, M ā rti ņ š Borodu š ķ is, P ē teris Alberts Tags: Research Paper Source Type: research

Autophagy Inhibition Stimulates Apoptosis in Oesophageal Squamous Cell Carcinoma Treated with Fasudil
Fasudil has been proven to be a promising chemotherapeutic drug for various malignancies. However, the potential anticancer effects of fasudil in oesophageal squamous cell carcinoma (ESCC) remain to be established. We confirmed the RhoA activity is inhibited by fasudil in ESCC cells. Then measured the effects of fasudil on apoptosis and autophagy in ESCC. Our study showed fasudil could both induce ESCCs apoptosis and autophagy, and when fasudil-induced autophagy was inhibited by knockdown of the essential autophagy genes (Beclin 1 or ATG7), and pharmacologic agent (chloroquine) treatment, both treatments also significantly...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Fa-Jun Xie, Qiu-Qing Zheng, Jing Qin, Ling-Ling Zhang, Na Han, Wei-Min Mao Tags: Research Paper Source Type: research

A Meta-Analysis: Methylenetetrahydrofolate Reductase C677T Polymorphism in Gastric Cancer Patients Treated with 5-Fu Based Chemotherapy Predicts Serious Hematologic Toxicity but Not Prognosis
In conclusion, MTHFR C677T polymorphism predicts severe hematologic toxicity in GC patients receiving 5-Fu based chemotherapy, but not the efficiency. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Cheng Tang, Shan Yu, Huiqin Jiang, Wei Li, Xiaojing Xu, Xi Cheng, Ke Peng, Erbao Chen, Yuehong Cui, Tianshu Liu Tags: Research Paper Source Type: research

Genetic variations in the PI3K/PTEN/AKT/mTOR pathway predict tumor response and disease-free survival in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy and radical surgery
Conclusions: The current study indicates that genetic variations within the PI3K/ PTEN/AKT/mTOR signaling pathway are associated with the clinical outcomes of LARC patients undergoing preoperative CRT followed by radical surgery. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jianhong Peng, Wenjuan Ma, Zhongguo Zhou, Yangkui Gu, Zhenhai Lu, Rongxin Zhang, Zhizhong Pan Tags: Research Paper Source Type: research

SULT1E1 inhibits cell proliferation and invasion by activating PPAR γ in breast cancer
In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Furthermore, enforced expression of SULT1E1 suppressed tumor cell migration and invasion. Moreover, we found that the activation of PPARγ was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. In addition, the overexpression of SULT1E1 significantly inhibited tumor growth in ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yali Xu, Xiaoyan Lin, Jiawen Xu, Haiyan Jing, Yejun Qin, Yintao Li Tags: Research Paper Source Type: research

Increased HE4 mRNA Expression Correlates with High Level Of eIF3a mRNA And Better Survival in Women with Epithelial Ovarian Cancer
Human epididymis protein 4 (HE4) is one of the most promising biomarkers for epithelial ovarian cancer (EOC). The majority of previous studies utilized the serum level or tissue protein expression of HE4 based upon immunohistochemistry (IHC) to evaluate the role of HE4 in the diagnosis, prognosis, and surveillance of EOC, but very little is known about HE4 mRNA expression. Eukaryotic translation initiation factor 3a (eIF3a) is implicated in oncogenesis and has been investigated extensively as a potential biomarker for malignancy. We previously reported a positive correlation between IHC expressions of eIF3a and HE4 in EOC....
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chen-Hui Luo, Min Zhao, Yu-Xi Tang, Shohreh Shahabi, Kai-Ning Fang, Yan Chen, Yan Tang, Xiao-Yan Chen, Jing Wang, Hong-Hao Zhou Tags: Research Paper Source Type: research

Integrated Oncogenomic Profiling of Copy Numbers and Gene Expression in Lung Adenocarcinomas without EGFR Mutations or ALK Fusion
Targeted therapies based on EGFR mutations or on the ALK fusion oncogene have become the standard treatment for certain patients with lung adenocarcinoma (LUAD). However, most LUAD patients have no EGFR mutation or ALK fusion, and their oncogenetic alterations remain to be characterized. Here we conducted an integrated analysis of public datasets to assess the genomic alterations of 23 highly lung cancer-associated genes. The copy numbers of these genes were measured in ten micro-dissected, paired tumors and normal lung tissues of LUAD patients without EGFR mutations or ALK fusion. The copy numbers of PTEN, RB1, HMGA2, and...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yanzhuo Luo, Bingjin Li, Guangxin Zhang, Yuxiao He, Jeeyoo Hope Bae, Fengping Hu, Ranji Cui, Runhua Liu, Zhou Wang, Lizhong Wang Tags: Research Paper Source Type: research