Neoadjuvant Chemotherapy Plays an Adverse Role in the Prognosis of Grade 2 Breast Cancer
Conclusions: NAC may have an adverse effect on breast cancer prognosis among patients with grade 2 tumors. These patients need not receive NAC, except when the patient has a strong desire for breast conservation, and this is unlikely to be achieved in the absence of NAC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xudong Zhu, Jinqi Xue, Xi Gu, Guanglei Chen, Fangning Cao, Huilian Shan, Dan Wang, Xinbo Qiao, Caigang Liu, Yixiao Zhang Tags: Research Paper Source Type: research

Overexpression of miR-4433 by suberoylanilide hydroxamic acid suppresses growth of CML cells and induces apoptosis through targeting Bcr-Abl
Conclusion: miR-4433 was identified as a microRNA targeting Bcr-Abl, which may be subject to epigenetic regulation of SAHA, a histone deacetylase inhibitor that has been approved by the US FDA for the treatment of cutaneous T-cell lymphoma. The findings of this study provide a molecular basis from another angle for the use of SAHA in the treatment of CML. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Haiyan Wu, Jingyi Yin, Zhengdong Ai, Guiming Li, Yan Li, Li Chen Tags: Research Paper Source Type: research

Panx1 promotes invasion-metastasis cascade in hepatocellular carcinoma
This study aimed to explore the role of Panx1 in the invasion and metastasis of HCC.Methods: The expressions of Panx1 in 126 cases of HCC were analyzed by immunohistochemistry (IHC). The effects of Panx1 on HCC cell metastasis and invasion were observed by transwell. The expression levels of Panx1 and epithelial-mesenchymal transition (EMT) related proteins in HCC cells and tissues were detected by western blot and IHC. The tumor metastatic abilities were compared between Panx1 knockout mice and nude mice.Results: The higher expression of Panx1 in HCC was positively correlated with tumor lymph node metastasis, TNM (tumor, ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Guangjun Shi, Chuanliang Liu, Yiming Yang, Liwei Song, Xueni Liu, Chuanxu Wang, Zhihai Peng, Hao Li, Lin Zhong Tags: Research Paper Source Type: research

Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma
Conclusions: Key biomarkers and pathways identified in the present study may enhance the comprehend of the molecular mechanisms underlying hepatocarcinogenesis. Additionally, mRNA expression of PRC1 and TOP2A may serve as potential diagnostic and prognostic biomarkers for HBV-related HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiwen Liao, Tingdong Yu, Chengkun Yang, Ketuan Huang, Xiangkun Wang, Chuangye Han, Rui Huang, Xiaoguang Liu, Long Yu, Guangzhi Zhu, Hao Su, Wei Qin, Jianlong Deng, Xianmin Zeng, Bowen Han, Quanfa Han, Zhengqian Liu, Xin Zhou, Junqi Liu, Yizhen Gong, Zheng Tags: Research Paper Source Type: research

Adenosquamous Carcinoma of the Stomach: A Population-based Study from the SEER Database
Purpose: Gastric adenosquamous carcinoma (ASC) is a rare pathological type with poorly understood clinicopathological features. The purpose of this study is to identify the characteristics of gastric ASC patients.Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database (2000 to 2014), patients with ASC (N=93) or adenocarcinoma (AC) (N=41794) of the stomach were included. The epidemiology, tumor features, treatment, and outcomes between these two groups were compared.Results: The incidences of ASC from 1983 to 2014 [annual percentage change (APC) = -3.5%, 95% confidence interval (CI) -4.9 to -2.1] and ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yugang Ge, Linling Lin, Xiang Ma, Dakui Luo, Liang Shi, Mingkun Jiang, Hao Fan, Yu He, Li Yang, Zekuan Xu Tags: Research Paper Source Type: research

Lack of associations between LIG3 gene polymorphisms and neuroblastoma susceptibility in Chinese children
Accumulating evidence suggests that dysregulation of the DNA non-homologous end-joining (NHEJ) repair system is a causative factor in many cancers, including high-risk neuroblastoma. A number of studies have shown that polymorphisms in the DNA ligase III (LIG3) gene, one of the key genes in the error-prone alternative NHEJ (a-NHEJ) pathway for DNA double-strand break (DSB) repair, are associated with a variety of cancers. Nevertheless, whether LIG3 polymorphisms contribute to neuroblastoma risk remains unknown. We investigated the correlation between neuroblastoma susceptibility and two LIG3 polymorphisms (rs1052536 C>T...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jiwen Cheng, Kongmei Wei, Yijuan Xin, Pu Zhao, Jiao Zhang, Wei Jia, Baijun Zheng Tags: Research Paper Source Type: research

Maternal and neonatal outcomes of cancer during pregnancy: a multi-center observational study
Cancer during pregnancy has increased because of the increased maternal age at the time of the first pregnancy and/or second child policy in China. The main purpose of the study is to report the existing data concerning the maternal and children's outcomes in pregnant women complicating cancer. In this multi-center, prospective cohort study, we compared women diagnosed with cancer during pregnancy and their children with matched women without cancer diagnoses. The primary outcomes were maternal and children's mortalities, as well as the Ages and Stages Questionnaires-3(ASQ) of children. A total of 80,524 pregnant women wer...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zhang YP, Duan J, Zhu XW, Li J, Shi Y Tags: Research Paper Source Type: research

The Defective Allele of Aldehyde Dehydrogenase 2 Gene is Associated with Favorable Postoperative Prognosis in Hepatocellular Carcinoma
Conclusions: HCC patients carrying a defective allele of ALDH2 had a favorable postoperative outcome. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Po-Han Huang, Ching-Chih Hu, Cheng-Hung Chien, Li-Wei Chen, Rong-Nan Chien, Yi-Shiuan Lin, Mei Chao, Chih-Lang Lin, Chau-Ting Yeh Tags: Research Paper Source Type: research

A novel gene signature combination improves the prediction of overall survival in urinary bladder cancer
Conclusions: This four-gene risk score might have potential clinical implications in the selection of high-risk urinary bladder cancer patients for aggressive therapy. The selected four genes might become potential therapeutic targets and diagnostic markers for urinary bladder cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Siteng Chen, Ning Zhang, Jialiang Shao, Tao Wang, Xiang Wang Tags: Research Paper Source Type: research

Clinicopathologic Features and Prognostic Implications of Golgi Phosphoprotein 3 in Non-small Cell Lung Cancer: A Meta-analysis
Conclusions: GOLPH3 could be a risk factor for progression of NSCLC and might act as a potential prognostic biomarker for NSCLC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Wenhua Shi, Wei Feng, Jian Wang, Cui Zhai, Qianqian Zhang, Qingting Wang, Yang Song, Xin Yan, Limin Chai, Pengtao Liu, Yuqian Chen, Cong Li, Manxiang Li Tags: Research Paper Source Type: research

Influencing Factors of High-Risk Human Papillomavirus Infection and DNA Load According to the Severity of Cervical Lesions in Female Coal Mine Workers of China
High-risk human papillomavirus (HR-HPV) plays an aetiological role in the progression of cervical cancer and precancerous lesions. Determining the risk factors of HR-HPV infection is useful for HR-HPV infection surveillance and control. We aimed to explore the influencing factors of HR-HPV infection in female coal mine workers, and to evaluate the associations between HR-HPV DNA load and cytological and histological changes of cervix. In total 6,325 participants completed standard questionnaire on potential influencing factors of HR-HPV infection and underwent gynecological examinations, HPV test as well as Thinprep cytolo...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yuanjing Lyu, Ling Ding, Tao Gao, Ying Li, Li Li, Ming Wang, Yang Han, Jintao Wang Tags: Research Paper Source Type: research

The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway
In this study, we investigated the role of B7-H3 in glucose metabolic reprogramming of OSCC cells in vitro and in vivo. We first detected the expression of B7-H3 in OSCC samples. Next, siRNAs and overexpression short-hairpin RNA of B7-H3 were transfected into SCC25 and Cal27 cells, and cell proliferation, migration and invasion were analyzed via CCK8, colony formation and transwell assays. Then glycolysis flux was determined through measuring glucose uptake and lactate production, and mRNA and protein expression levels were determined by real-time quantitative PCR and western blot respectively. The results presented here s...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zhangao Li, Jiyuan Liu, Lin Que, Xiufa Tang Tags: Research Paper Source Type: research

The Role of Surgical Resection Following Tyrosine Kinase Inhibitors Treatment in Patients with Advanced Gastrointestinal Stromal Tumors: A Systematic Review and Meta-analysis
Background The benefit of surgical resection for advanced gastrointestinal stromal tumors (GISTs) following tyrosine kinase inhibitors (TKIs) treatment was still under debate. The present meta-analysis was designed to assess the value of surgical resection for the prognosis of patients with metastatic, recurrence and unresectable GISTs. Methods A systematic search of PubMed Central, PubMed, EMBASE and the Cochrane Library database was performed. Relevant studies of the role of surgery in advanced GISTs published before 1 May 2019 were identified. The quality of studies was assessed by the Newcastle-Ottawa Quality Assessmen...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yinghao Guo, Jinqiang Liu, Fei Wang, Qiao Wang, Gaozan Zheng, Shushang Liu, Xiao Lian, Hongwei Zhang, Fan Feng Tags: Research Paper Source Type: research

Prognostic Value of Survival of MicroRNAs Signatures in Non-small Cell Lung Cancer
Conclusion: Overall, eight miRNAs were closely correlated with survival of NSCLC patients, and the constructed two four-miRNA signatures could be respectively used as prognostic markers in LUAD and LUSC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Bo Chen, Tianshun Gao, Weiwei Yuan, Weihong Zhao, Tza-Huei Wang, Jianqing Wu Tags: Research Paper Source Type: research

The prognostic role of 18F-FDG PET/CT baseline quantitative metabolic parameters in peripheral T-cell lymphoma
Conclusions: Our study shows that high WBTLG, WBMTV and WBSUVmax could predict a relatively poor prognosis, and has a highly significant association with PIT and IPI.WBTLG could be an independent predictive factor for survival outcomes in patients with PTCL. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jun Xia, Hua-Yuan Zhu, Jin-Hua Liang, Chong-Yang Ding, Li Wang, Wei Wu, Lei Cao, Tian-Lv Li, Jian-Yong Li, Wei Xu Tags: Research Paper Source Type: research

ERR α Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration
In this study, we found that estrogen-related receptor alpha (ERRα, also called NR3B1) binds to OTUB1 promoter and regulates its expression in colorectal cancer. Furthermore, ERRα promoted the migration of CRC cells by inducing vimentin expression via OTUB1. Our data show that OTUB1 is a novel target of ERRα and indicate that ERRα-OTUB1 signaling may play a significant role in CRC metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yi Zhou, Qingzhu Jia, Xiaoqing Meng, Diangang Chen, Bo Zhu Tags: Research Paper Source Type: research

Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma
This study aimed to develop the drug delivery system of UA-loaded polymer micelles (UA-PMs) to overcome the disadvantages of UA in clinical application thus enhancing antitumor effect on hepatocellular carcinoma. UA-PMs was prepared and characterized for the physicochemical properties. It was investigated the cell-growth inhibition effect of UA-PMs against the human hepatocellular carcinoma cell line HepG2 and human normal liver cell line L-02. UA-PMs was evaluated about the in vivo toxicity and the antitumor activity. We took a diblock copolymer of methoxy poly (ethylene glycol)-poly(L-lactic acid) (mPEG-PLA) as carrier m...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Meiling Zhou, Youping Yi, Li Liu, Yan Lin, Jian Li, Jinghua Ruan, Zhirong Zhong Tags: Research Paper Source Type: research

Cucurbitacin E inhibits cellular proliferation and enhances the chemo-response in gastric cancer by suppressing AKt activation
Conclusion: In summary, we present the first evidence of the efficacy of CuE for the inhibition of gastric cancer growth and the synergistic antitumorigenic effect of CuE and Dox, both in vitro and in vivo. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Wenzhang Si, Jia Lyu, Zhengchuang Liu, Chunyang Wang, Jingjing Huang, Liping Jiang, Tonghui Ma Tags: Research Paper Source Type: research

Histological tumor response assessment in colorectal liver metastases after neoadjuvant chemotherapy: impact of the variation in tumor regression grading and peritumoral lymphocytic infiltration
Conclusions: Variation in TRG scores and peritumoral lymphocytic infiltration may be proposed as secondary pathological parameters to evaluate the pathological response to NACT and predict the risk of recurrence after liver surgery. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yibo Cai, Xingang Lu, Xiu Zhu, Haixing Ju, Wenyong Sun, Wei Wu Tags: Research Paper Source Type: research

Oncogenic Wnt3a: A Candidate Specific Marker and Novel Molecular Target for Hepatocellular Carcinoma
Conclusions: Oncogenic Wnt3a could be considered as a candidate biomarker and novel target for HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Wenjie Zheng, Min Yao, Miao Fang, Liuhong Pan, Li Wang, Junling Yang, Zhizhen Dong, Dengfu Yao Tags: Research Paper Source Type: research

Trimethylamine-N-oxide as One Hypothetical Link for the Relationship between Intestinal Microbiota and Cancer - Where We Are and Where Shall We Go?
Previous epidemiological studies had provided evidence for a link between the microbial dysbiosis and cancer, particularly colorectal cancer (CRC), yet the molecular basis of this link remains elusive. Recently, the association between plasma levels of trimethylamine-N-oxide (TMAO), an oxidised form of trimethylamine (TMA), and risks of various cancers was demonstrated. The discovery could potentially provide an alternative explanation for the aforementioned link, as TMA production is attributed to intestinal bacteria. Current evidence suggests that inflammation could be a potential molecular mechanism to explain the link ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Carmen Wing Han Chan, Bernard Man Hin Law, Mary Miu Yee Waye, Judy Yuet Wa Chan, Winnie Kwok Wei So, Ka Ming Chow Tags: Review Source Type: research

The transcriptome difference between colorectal tumor and normal tissues revealed by single-cell sequencing
In this study, we analyzed the single-cell transcriptome of 272 colorectal cancer (CRC) epithelial cells and 160 normal epithelial cells and identified 342 discriminative transcripts using advanced machine learning methods. The most discriminative transcripts were LGALS4, PHGR1, C15orf48, HEPACAM2, PERP, FABP1, FCGBP, MT1G, TSPAN1 and CKB. We further clustered the 342 transcripts into two categories. The upregulated transcripts in CRC epithelial cells were significantly enriched in Ribosome, Protein processing in endoplasmic reticulum, Antigen processing and presentation and p53 signaling pathway. The downregulated transcr...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Guo-Liang Zhang, Le-Lin Pan, Tao Huang, Jin-Hai Wang Tags: Research Paper Source Type: research

Establishing the prediction models for recurrence and progression of T1G3 bladder urothelial carcinoma
We aim to determine clinical recurrence and progression risk factors of T1G3 bladder cancer (BCa), and to establish recurrence and progression prediction models. 5-year follow-up records of 106 T1G3 BCa patients from January 2012 to December 2016 were analyzed for recurrence and progression. Two-sample T-test, Chi-square test, Mann-Whitney test, Kaplan-Meier curves, Cox univariate and multivariate analyses were performed to determine the independent risk factors. Effective prognostic nomograms were established to provide individualized prediction, and the calibration curves were founded to evaluate the agreements of the pr...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Song Chen, Mengxin Lu, Tianchen Peng, Yejinpeng Wang, Xuefeng Liu, Yu Xiao, Xinghuan Wang Tags: Research Paper Source Type: research

Eribulin in Triple Negative Metastatic Breast Cancer: Critic Interpretation of Current Evidence and Projection for Future Scenarios
Triple negative breast cancer (TNBC) is characterized by distinctive biological features that confer an aggressive clinical behavior. In TNBC patients, the absence of well-defined driver pathways such as hormonal receptor expression or hyperactivation of the human epidermal growth factor receptor 2 (HER2) significantly reduce the spectrum of therapeutic options, which are currently mainly confined to chemotherapy. Thus far, median overall survival for patients with metastatic TNBC is about 9-12 months with conventional cytotoxic agents. However, the heterogeneity recently revealed at a gene expression level inside the TNBC...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Laura Pizzuti, Eriseld Krasniqi, Giacomo Barchiesi, Marco Mazzotta, Maddalena Barba, Antonella Amodio, Gioia Massimiani, Fabio Pelle, Ramy Kayal, Enrico Vizza, Antonino Grassadonia, Silverio Tomao, Aldo Venuti, Teresa Gamucci, Paolo Marchetti, Clara Natol Tags: Review Source Type: research

Expression of EMT-Related Genes CAMK2N1 and WNT5A is increased in Locally Invasive and Metastatic Prostate Cancer
Conclusions: Globally, our findings suggest an association between PCa aggressiveness and increased expression of CAMK2N1 and WNT5A, reflecting the acquisition of effective EMT characteristics by PCa cells. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Isa Carneiro, Filipa Quintela-Vieira, Jo ã o Lobo, Catarina Moreira-Barbosa, Francisco Duarte Menezes, Ana Teresa Martins, Jorge Oliveira, Regina Silva, Carmen Jer ó nimo, Rui Henrique Tags: Research Paper Source Type: research

Impact of primary tumor location in patients with RAS wild-type metastatic colon cancer treated with first-line chemotherapy plus anti-EGFR or anti-VEGF monoclonal antibodies: a retrospective multicenter study
Emerging evidence supports a prognostic role of primary tumor location in metastatic colon cancer (mCC). We conducted a retrospective analysis to evaluate the effect of tumor location on prognosis and efficacy of biological agents (anti-EGFR, Cetuximab and Panitumumab, or anti-VEGF, Bevacizumab) added to first-line chemotherapy in patients with RAS wild-type (wt) mCC. Patients with newly diagnosed RAS wt mCC candidates to first-line chemotherapy with anti-EGFRs or Bevacizumab were selected. Clinical outcomes were assessed and stratified by tumor location and type of treatment. Overall, 351 patients met the inclusion criter...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Antonino Grassadonia, Pietro Di Marino, Corrado Ficorella, Alessio Cortellini, Katia Cannita, Alessandro Parisi, Teresa Gamucci, Federica Zoratto, Patrizia Vici, Maddalena Barba, Ettore Porreca, Matteo Neri, Angelo Veronese, Clara Natoli, Michele De Tursi Tags: Research Paper Source Type: research

Independent effect of postoperative neutrophil-to-lymphocyte ratio on the survival of pancreatic ductal adenocarcinoma with open distal pancreatosplenectomy and its nomogram-based prediction
Conclusions: poNLR can be a proven, inexpensive and novel survival predictor of PDAC patients with ODPS. One more advanced and accurate predictive model will be achieved to assist in risk stratification via the incorporation of poNLR into nomograms. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ning Pu, Hanlin Yin, Guochao Zhao, Abulimiti Nuerxiati, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Dayong Jin, Wenhui Lou, Wenchuan Wu Tags: Research Paper Source Type: research

A novel and validated nomogram to predict overall survival for gastric neuroendocrine neoplasms
Conclusions: The novel prognostic nomogram showed superior predictive value in overall survival of G-NENs. It might be a useful tool for clinicians in estimating individual survival in G-NENs patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Sheng Zhang, Yi Xin Tong, Xin Hua Zhang, Yu Jie Zhang, Xiang Shang Xu, Ai Tang Xiao, Teng Fei Chao, Jian Ping Gong Tags: Research Paper Source Type: research

HIF-1 α rs11549465 C > T polymorphism contributes to increased cancer susceptibility: Evidence from 49 studies
HIF-1α (hypoxia-inducible factor-1α) is a transcriptional factor that participates in the regulation of oxygen homeostasis. Despites numbers of case-control studies working on this area, the actual relationship of HIF-1α gene generic variant rs11549465 C>T imposing on cancer susceptibility remains unveiled. To get a better understanding of such relationship, this meta-analysis was carried out by incorporating all eligible case-control studies. Qualified articles were acquired from PubMed, CNKI, EMBASE, PMC, and Wanfang database update to April 2019. Odds ratios (ORs) and their corresponding 95% confide...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Hu-Nian Li, Ting He, Yong-Jiu Zha, Fang Du, Jie Liu, Hui-Ran Lin, Wen-Zi Yang Tags: Research Paper Source Type: research

Cip2a/miR-301a feedback loop promotes cell proliferation and invasion of triple-negative breast cancer
In this study, we identified that miR-301a is a novel target of Cip2a in TNBC cell lines by miRNA microarray analysis. We found that Cip2a increases E2F1 expression, which in turn transcriptional activates miR-301a by occupying the miR-301a host gene SKA2 promoter. Moreover, we found that miR-301a level is significantly increased in TNBC tissues, and up-regulation of miR-301a is responsible for Cip2a-induced cell proliferation and invasion of TNBC cells. Furthermore, miR-301a feedback promotes the expression of Cip2a via activation of ERK/CREB signaling. Together, our study suggests an auto-regulatory feedback loop between...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jiang Yin, Danyang Chen, Kai Luo, Minying Lu, Yixue Gu, Shanshan Zeng, Xiangzhou Chen, Ying Song, Zhijie Zhang, Guopei Zheng, Zhimin He, Hao Liu Tags: Research Paper Source Type: research

Long-term Results of Conversion Therapy for Initially Unresectable Gastric Cancer: Analysis of 122 Patients at the National Cancer Center in China
Conclusions: Conversion therapy may provide long-term survival for patients with initially unresectable gastric cancer. Postoperative adjuvant chemotherapy might be recommended for patients who underwent conversion therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Tongbo Wang, Nianchang Wang, Hu Ren, Hong Zhou, Aiping Zhou, Jing Jin, Yingtai Chen, Dongbing Zhao Tags: Research Paper Source Type: research

Intraoperative Chemotherapy with a Novel Regimen Improved the Therapeutic Outcomes of Colorectal Cancer
This study sought to evaluate the efficacy of a novel intraoperative chemotherapy (IOC) regimen that consists of hydroxycamptothecin, tumor necrosis factor (TNF), 5-fluorouracil (5-FU), and calcium folinate (CF) on the outcomes of colorectal cancer (CRC).Methods: In total, 551 CRC patients who had undergone surgical resection were evaluated. Among these patients, 247 were treated with postoperative adjuvant chemotherapy, and 193 were treated with intraoperative chemotherapy. Of the CRC patients who underwent chemotherapy, 52 were treated with both postoperative adjuvant chemotherapy and intraoperative chemotherapy. Patient...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zhihua Liu, Yifeng Zou, Yuming Rong, Xingyuan Shi, Chen Li, Chao Li, Yinghai Tian, Hongcheng Lin, Min Liu, Jinsheng Weng, Ting Liu, Xiaomei Li, Chao Lei, Weipeng Li, Xinke Zhou Tags: Research Paper Source Type: research

The Value of LncRNA BCAR4 as a Prognostic Biomarker on Clinical Outcomes in Human Cancers
Background: This updated meta-analysis aimed to analyze available data to explore the prognostic value of long noncoding RNA breast cancer anti-estrogen resistance 4 (BCAR4) in various human malignancies. Methods: Literature retrieval was performed by systematic searching several authoritative databases, including Pubmed, PMC database, Web of Science, the Cochrane Library, Embase, and CNKI database up to Feb 10, 2019. Data were extracted and subsequently crosschecked, and discrepancies were discussed to reach consensus. Quality of the eligible studies was evaluated by Newcastle-Ottawa Scale (NOS). The fixed- or random-effe...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chao Tu, Xiaolei Ren, Jieyu He, Chenghao Zhang, Ruiqi Chen, Wanchun Wang, Zhihong Li Tags: Research Paper Source Type: research

Long non-coding RNA LOC554202 promotes acquired gefitinib resistance in non-small cell lung cancer through upregulating miR-31 expression
In conclusion, these data will help us develop potential therapeutic targets for the diagnosis and treatment of acquired EGFR TKI resistance in EGFR-mutant NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jing He, Shidai Jin, Wei Zhang, Deqin Wu, Jun Li, Jing Xu, Wen Gao Tags: Research Paper Source Type: research

Suppression of non-small cell lung cancer migration and invasion by hsa-miR-486-5p via the TGF- β /SMAD2 signaling pathway
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. SMAD family member 2 (SMAD2) is a key element downstream of the transforming growth factor beta (TGF-β) signaling pathway that regulates cancer metastasis by promoting the epithelial-mesenchyme transition (EMT). MicroRNA miR-486-5p is a tumor suppressor in NSCLC progression. However, it remains unclear whether miR-486-5p is implicated in TGF-β signaling and EMT in NSCLC. In the present study, high expression of SMAD2 mRNA was detected in NSCLC tissues and cell lines, and was associated with poor survival of patients with NS...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Tao Chen, Jianjie Zhu, Tingting Cai, Wenwen Du, Yang Zhang, Qingqing Zhu, Zeyi Liu, Jian-an Huang Tags: Research Paper Source Type: research

Downregulated Salt-inducible Kinase 3 Expression Promotes Chemoresistance in Serous Ovarian Cancer via the ATP ‐ binding Cassette Protein ABCG2
Conclusion: Our results demonstrated that serous EOC patients with low SIK3 expression have poor prognosis, which is associated with chemoresistance mediated by ABCG2 upregulation. SIK3 and ABCG2 expression levels may be potential prognostic markers to predict the outcome in serous EOC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yu-Ling Liang, Chin-Han Wu, Chieh-Yi Kang, Chang-Ni Lin, Neng-Yao Shih, Sheng-Hsiang Lin, Yeong-Chang Chen, Keng-Fu Hsu Tags: Research Paper Source Type: research

Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway
In conclusion, DCA restored chemosensitivity through miR-543/PTEN/Akt/mTOR pathway, and miR-543 may be a potential marker or therapeutic target for chemoresistance in CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yu Liang, Danxi Zhu, Liming Zhu, Yichao Hou, Lidan Hou, Xin Huang, Linjing Li, Yu Wang, Lei Li, Huimin Zou, Tianqi Wu, Mengfei Yao, Jianhua Wang, Xiangjun Meng Tags: Research Paper Source Type: research

High expression of CHML predicts poor prognosis of multiple myeloma
Multiple myeloma is a hematological tumor with a malignant proliferation of myeloma cells. Although the survival time after treatment has improved, the recurrence rate of MM is still high. Choroideremia-like (CHML) protein is essential for the prenylation modification of various Rab proteins and it exerts biological effects on vesicle trafficking and signal transduction. However, little is identified about the relationship between CHML gene and MM. We integrated gene expression profiles of 1907 MM patients (1959 MM samples) from the 7 datasets. The relationship between CHML gene expression level and event-free survival (EF...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Weilong Zhang, Ling Cao, Xiaoni Liu, Xue He, Ye Zhang, Zuozhen Yang, Ping Yang, Jing Wang, Kai Hu, Xiuru Zhang, Weiyou Liu, Xiaoliang Yuan, Hongmei Jing Tags: Research Paper Source Type: research

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
Conclusion: DHA induces autophagy in HUVECs by inhibition of the Akt/mTOR pathway (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jing Liu, Yanjun Ren, Yinglong Hou, Caiqing Zhang, Bei Wang, Xiaorui Li, Rong Sun, Ju Liu Tags: Research Paper Source Type: research

NT-3/TrkC Axis Contributes to the Perineural Invasion and the Poor Prognosis in Human Salivary Adenoid Cystic Carcinoma
The present study was aimed to investigate the role and mechanism of neurotrophin-3 (NT-3) and its specific receptor tropomyosin receptor kinase C (TrkC) in the perineural invasion (PNI) process of the salivary adenoid cystic carcinoma (SACC). The co-cultured system between SACC cells and Schwann cells (SCs) was employed to detect the expression of NT-3 and TrkC. The results of ELISA, qRT-PCR and western blot showed that NT-3 was noticeably elevated in the co-cultured SACC-83 cells, while TrkC was increased in the co-cultured SCs. The results of scratch wound healing, migration, and 3D co-culture assays showed that the dir...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Huan Li, Zihui Yang, Weiqi Wang, Jun Wang, Jianying Zhang, Junye Liu, Tao Yang, Yaowu Yang, Jianhua Wei, Delin Lei, Xinjie Yang Tags: Research Paper Source Type: research

Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma
In this study, we found that overexpression of Lin28B significantly increased the paclitaxel chemoresistance in two different HCC cells lines while silencing Lin28B reduced the chemoresistance in paclitaxel-resistance HCC cells. Curcumin, a natural anti-cancer agent, increased the sensitivity of HCC cells to paclitaxel through inhibiting NF-κB stimulated Lin28B expression both in vitro and in vivo. Furthermore, by analyzing TCGA (The Cancer Genome Atlas) LIHC (liver hepatocellular carcinoma) and GSE14520 databases, we found that Lin28B was highly upregulated in HCC tissue compared with that in normal tissue and assoc...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Nan Tian, Wenbing Shangguan, Zuolin Zhou, Yao yao, Chunlei Fan, Lijun Cai Tags: Research Paper Source Type: research

High expression of DOCK2 indicates good prognosis in acute myeloid leukemia
DOCK family proteins are evolutionarily conserved guanine nucleotide exchange factors for Rho GTPase with different cellular functions. It has been demonstrated that DOCK1 had adverse prognostic effect in acute myeloid leukemia (AML). We first analyzed data of 85 AML patients who were treated with chemotherapy and had available DOCK1 to DOCK11 expression information and found that DOCK1 and DOCK2 had prognostic significance in AML. In view of the known prognosis of DOCK1 in AML, we then explored the prognostic role of DOCK2. One hundred fifty-six AML patients with DOCK2 expression data were extracted from The Cancer Genome...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ning Hu, Yifan Pang, Hongmian Zhao, Chaozeng Si, Hui Ding, Li Chen, Chao Wang, Tong Qin, Qianyu Li, Yu Han, Yifeng Dai, Yijie Zhang, Jinlong Shi, Depei Wu, Xinyou Zhang, Zhiheng Cheng, Lin Fu Tags: Research Paper Source Type: research

Establishment and Characterization of a CTC Cell Line from Peripheral Blood of Breast Cancer Patient
Conclusions: CTC-3 cells are a better model for investigating the malignant behavior of breast cancer than existing cell lines. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Pan Zhao, Wenbin Zhou, Chang Liu, Huirong Zhang, Zhiqiang Cheng, Weiqing Wu, Kaisheng Liu, Hong Hu, Caineng Zhong, Yayuan Zhang, Dongxian Zhou, Feiyuan Liu, Yong Dai, Jianhong Wang, Chang Zou Tags: Research Paper Source Type: research

CircRNAs and its relationship with gastric cancer
Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analysis of the reported results, we find that circRNAs not only participate in the regulation of gastric cancer (GC) cell biological behaviors, such as proliferation, invasion, migration and epithelial mesenchymal transition (EMT), but also are related to the clinicopathological features of GC such as tumor differe...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xinxin Fang, Jing Wen, Mingjun Sun, Yuan Yuan, Qian Xu Tags: Review Source Type: research

Indirect comparison between immune checkpoint inhibitors and targeted therapies for the treatment of melanoma
Conclusions: For the unresectable late-stage melanoma, IMM may be a better choice for the combined treatment with chemotherapy. If the chemotherapy is not tolerable for patients, BRAFi involved TAR can be considered. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Minliang Wu, Yuchong Wang, Yalong Xu, Ji Zhu, Chuan Lv, Mengyan Sun, Rui Guo, Yu Xia, Wei Zhang, Chunyu Xue Tags: Research Paper Source Type: research

Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin
This study explored the epigenetic regulation and mechanism of SLFN11 in human gastric cancer.Methods: Eight human gastric cancer cell lines and 201 cases of primary gastric cancer were analyzed. Methylation specific PCR, flow cytometry, xenograft mouse model and siRNA technique were employed.Results: SLFN11 was methylated in 29.9% (60/201) of primary gastric cancer. The expression of SLFN11 was regulated by promoter region methylation. Methylation of SLFN11 was significantly associated with tumor size (p
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yaojun Peng, Li Wang, Liangliang Wu, Ling Zhang, Guangjun Nie, Mingzhou Guo Tags: Research Paper Source Type: research

Plan quality comparison for cervical carcinoma treated with Halcyon and Trilogy intensity-modulated radiotherapy
Conclusions: All Halcyon treatment plans were recognized as clinically acceptable and had statistically better OAR sparing with higher delivery efficiency. The Halcyon system exhibited fast treatment delivery of IMRT with good dosimetric agreement using ArcCHECK. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chengqiang Li, Jinhu Chen, Jian Zhu, Guanzhong Gong, Cheng Tao, Zhenjiang Li, Jie Lu, Yong Yin Tags: Research Paper Source Type: research

DNA Replication and Sister Chromatid Cohesion 1 (DSCC1) of the Replication Factor Complex CTF18-RFC is Critical for Colon Cancer Cell Growth
DNA replication and sister chromatid cohesion 1 (DSCC1) combines with chromosome transmission-fidelity protein 18 (CTF18) to form a CTF18-DSCC1-CTF8 (CTF18-1-8) module, which in combination with CTF18-replication factor C (RFC) acts as a proliferating cell nuclear antigen (PCNA) loader during DNA replication-associated processes. It was found that DSCC1 was overexpressed in tumor tissues from patients with colon cancer and that the survival probability of patients with colon cancer was lower when the expression of cytosolic DSCC1 was higher in tumor regions (P=0.047). By using DSCC1- or CTF18-knockdown cell lines (HCT116-s...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jong-Tae Kim, Hee Jun Cho, Sang Yoon Park, Byung Moo Oh, Yo Sep Hwang, Kyoung Eun Baek, Young-Ha Lee, Hee Cheol Kim, Hee Gu Lee Tags: Research Paper Source Type: research

Potential Therapeutic Roles of Exosomes in Multiple Myeloma: A Systematic Review
Multiple myeloma (MM) is the second most prevalent hematological malignancy. In spite of the remarkable progress in understanding the biology and therapy of MM, curing this disease remains difficult, which calls for more effective treatment strategies. As vital communicators between different cells, exosomes have been verified to be crucial to cancer diagnosis, treatment, and prognosis. Exosomes in MM patients show a different expression profile compared with those in healthy individuals. In this review, we summarize potential therapy roles exosomes may play in MM. The specific expression of certain components in exosomes ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Mengzhen Li, Bing Xia, Yi Wang, M. James You, Yizhuo Zhang Tags: Review Source Type: research

Long-term cardiac-specific mortality among 44,292 acute myeloid leukemia patients treated with chemotherapy: a population-based analysis
Conclusion: Cardiac-specific mortality in AML patients receiving chemotherapy is higher than that in the general population. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Guangli Li, Zhijuan Zhou, Wencong Yang, Hao Yang, Xiuwu Fan, Yuelan Yin, Liyun Luo, Jinyou Zhang, Niujian Wu, Zibin Liang, Jianting Ke, Jian Chen Tags: Research Paper Source Type: research