Systemic Inflammation Biomarkers Predict Survival in Patients of Early Stage Non-Small Cell Lung Cancer Treated With Stereotactic Ablative Radiotherapy - A Single Center Experience
Conclusions: In patients of early stage NSCLC who received SABR, pretreatment NLR, PLR, and LMR could be considered useful prognostic indicators of OS. These metrics may provide reliable and convenient predictors to identify patients who would benefit from SABR. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hui Luo, Hong Ge, Yingying Cui, Jiangong Zhang, Ruitai Fan, Anping Zheng, Xiaoli Zheng, Yanan Sun Tags: Research Paper Source Type: research

Albumin-to-Alkaline Phosphatase Ratio as an Independent Prognostic Factor for Overall Survival of Advanced Hepatocellular Carcinoma Patients without Receiving Standard Anti-Cancer Therapies
Background Albumin-to-Alkaline Phosphatase Ratio (ALB/ALP ratio, AAPR), a newly developed index of liver function, has been rarely discussed about its prognostic value in malignancies. The current study attempted to evaluate the prognostic prediction of AAPR in advanced HCC.Methods 237 advanced HCC patients who refused any standard anti-cancer therapies were retrospectively analyzed. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Univariate analyses using Kaplan-Meier method and log-rank test, and multivariate analysis using Cox proportional hazards regression model were conduc...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xiurong Cai, Zhanhong Chen, Jie Chen, Xiaokun Ma, Mingjun Bai, Tiantian Wang, Xiangwei Chen, Donghao Wu, Li Wei, Xing Li, Qu Lin, Jingyun Wen, Danyun Ruan, Zexiao Lin, Min Dong, Xiangyuan Wu Tags: Research Paper Source Type: research

KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck
Conclusions: These results indicate that KDM5B is a valuable biomarker that can be used to predict SCCHN patient outcome. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Donghai Huang, Yuanzheng Qiu, Guo Li, Chao Liu, Li She, Diekuo Zhang, Xiyu Chen, Gangcai Zhu, Xin Zhang, Yongquan Tian, Yong Liu Tags: Research Paper Source Type: research

Activity and Immune Correlates of a Programmed Death-1 Blockade Antibody in the treatment of Refractory Solid Tumors
Conclusions: An anti-PD-1 antibody produced objective responses in approximately 25% patients with various solid tumors, demonstrating that it could improve the immune system in vivo. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chang Jiang, Xiuyu Cai, Hongxia Zhang, Xiaojun Xia, Bei Zhang, Liangping Xia Tags: Research Paper Source Type: research

Investigating Esophageal Stent-Placement Outcomes in Patients with Inoperable Non-Cervical Esophageal Cancer
Background: Esophageal stent insertion in patients with inoperable esophageal cancer is usually accompanied with relatively high adverse symptoms and even mortality. The current study aims at investigating the outcomes of esophageal stenting in patients with inoperable non-cervical esophageal cancer.Materials and Methods: The current descriptive-analytical research evaluates 25 patients with esophageal cancer. The stent was placed in esophagus based upon endoscopy analysis with or without fluoroscopy and then the stent position and its opening was investigated by making use of CXRand Gastrografin studies. Demographic chara...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Mojgan Forootan, Morteza Tabatabaeefar, Nariman Mosaffa, Hormat Rahimzadeh Ashkalak, Mohammad Darvishi Tags: Research Paper Source Type: research

Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing
Breast cancer is the leading diagnosed cancer for women globally. Evolution of breast cancer in tumorigenesis, metastasis and treatment resistance appears to be driven by the aberrant gene expression and protein degradation encoded by the cancer genomes. The uncontrolled cancer growth relies on these cellular events, thus constituting the cancerous programs and rendering the addiction towards them. These programs are likely the potential anticancer biomarkers for Personalized Medicine of breast cancer. This review intends to delineate the impact of the CRSPR/Cas-mediated genome editing in identification and validation of t...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Haitao Yang, MariaLynn Jaeger, Averi Walker, Daniel Wei, Katie Leiker, Tao Weitao Tags: Review Source Type: research

Interferon- γ and Colorectal Cancer: an up-to date
Colorectal cancer still remains the third cause of cancer death among cancer patients. Early diagnosis is crucial and they can be either endoscopic or with blood biomarkers. Endoscopic methods consist of gastroscopy and colonoscopy, however; in recent years, endoscopic ultrasound is being used. The microenvironment is very important for the successful delivery of the treatment. Several proteins and hormones play a crucial role in the efficiency of the treatment. In the current mini review we will focus on interferon-γ. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Christoforos Kosmidis, Konstantinos Sapalidis, Triantafyllia Koletsa, Maria Kosmidou, Christoforos Efthimiadis, George Anthimidis, Nikolaos Varsamis, Nikolaos Michalopoulos, Charilaos Koulouris, Stefanos Atmatzidis, Lazaros Liavas, Titika-Marina Strati, G Tags: Review Source Type: research

Early and Partial Reduction in CD4+Foxp3+ Regulatory T Cells during Colitis-Associated Colon Cancer Induces CD4+ and CD8+ T Cell Activation Inhibiting Tumorigenesis
Colorectal cancer (CRC) is the second most commonly diagnosed cancer in women and the third in men in North America and Europe. CRC is associated with inflammatory responses in which intestinal pathology is caused by different cell populations including a T cell dysregulation that concludes in an imbalance between activated T (Tact) and regulatory T (Treg) cells. Treg cells are CD4+Foxp3+ cells that actively suppress pathological and physiological immune responses, contributing to the maintenance of immune homeostasis. A tumor-promoting function for Treg cells has been suggested in CRC, but the kinetics of Treg cells durin...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jonadab E. Olgu í n, Itzel Medina-Andrade, Emmanuel Molina, Armando V á zquez, Thalia Pacheco-Fern á ndez, Rafael Saavedra, Carlos P é rez-Plasencia, Yolanda I. Chirino, Felipe Vaca-Paniagua, Luis E. Arias-Romero, Emma B. Gutierrez-Cirlos, Sonia A. Le Tags: Research Paper Source Type: research

Lenvatinib in Advanced Radioiodine-Refractory Thyroid Cancer - A Retrospective Analysis of the Swiss Lenvatinib Named Patient Program
Conclusions: Our results show that lenvatinib has reasonable clinical activity in unselected patients with RAI-refractory thyroid cancer with nearly two-third of patients showing clinical benefit. The toxicity profile of lenvatinib is manageable. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Catharina Balmelli, Nikola Railic, Marco Siano, Kristin Feuerlein, Richard Cathomas, Valerie Cristina, Christiane G ü thner, Stefan Zimmermann, Sabine Weidner, Miklos Pless, Frank Stenner, Sacha I. Rothschild Tags: Research Paper Source Type: research

Clinical-pathological Characteristics and Prognostic Factors for Papillary Thyroid Microcarcinoma in the Elderly
Background: The incidence of papillary thyroid microcarcinoma (PTMC) has increased dramatically over the past three decades worldwide. The annual rate of increase in the elderly (≥65) PTMC patients is 1.4 times higher than that in the adult (
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jing Tang, Hans B. Liu, Lujiao Yu, Xin Meng, Sean X. Leng, Haiyan Zhang Tags: Research Paper Source Type: research

Cancer vaccine: learning lessons from immune checkpoint inhibitors
Cancer vaccines have been exclusively studied all through the past decades, and have made exceptional achievements in cancer treatment. Few cancer vaccines have been approved by the US Food and Drug Administration (FDA), for instance, Provenge, which was approved for the treatment of prostate carcinoma in 2012. Moreover, more recently, T-VEC got approval for the treatment of melanoma. While, the overall therapeutic effects of cancer vaccines have been taken into consideration as below expectations, low antigenicity of targeting antigen and tumor heterogeneity are the two key limiting barriers encountered by the cancer vacc...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: ZhenLong Ye, Qiming Qian, HuaJun Jin, QiJun Qian Tags: Review Source Type: research

A single nucleotide polymorphism in CYP1B1 leads to differential prostate cancer risk and telomere length
CONCLUSION: Our findings suggest that genetic variants within CYP1B1 may confer genetic susceptibility to PCa by altering telomere length. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Cheng-Yuan Gu, Gao-Xiang Li, Yu Zhu, Hua Xu, Yao Zhu, Xiao-Jian Qin, Dai Bo, Ding-Wei Ye Tags: Research Paper Source Type: research

Immunotherapy of patient with hepatocellular carcinoma using cytotoxic T lymphocytes ex vivo activated with tumor antigen-pulsed dendritic cells
Purpose The aim of this study was to evaluate the clinical response of immunotherapy with dendritic cell-cytotoxic T lymphocytes (DC-CTLs) in patients with hepatocellular carcinoma (HCC).Method Sixty-eight patients with a confirmed diagnosis of HCC and who received follow-up until December 2015 were enrolled. We measured immune phenotypes of DCs and activated T cells using flow cytometry and clinical indexes using an electrochemiluminescence method.Results DCs exhibited up-regulation of the maturation markers CD83, CD80, CD11c, and CD86 on day8. Levels of IFN-γ and TNF-α were higher in the DCs pulsed with tumor...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ying Wang, Xijing Yang, Yi Yu, Zenghui Xu, Yan Sun, Hui Liu, Jingbo Cheng, Min Liu, Bibo Sha, Linfang Li, Na Ding, Zhong Li, Huajun Jin, Qijun Qian Tags: Research Paper Source Type: research

Genistein Promotes Proliferation of Human Cervical Cancer Cells Through Estrogen Receptor-Mediated PI3K/Akt-NF- κ B Pathway
Phytoestrogens are polyphenol compounds which have similar structure to 17β-estradiol (E2), a kind of main estrogen in women. Thus, phytoestrogens may affect the reproductive and endocrine systems, leading to the development of estrogen-related cancers. The effect of genistein (Gen), one of the most studied phytoestrogens, on human cervical cancer cells (HeLa) was investigated in this study. It was found that Gen at concentrations of 0.001, 0.01, 0.1 and 1 µmol·L-1 promoted the proliferation of HeLa cells in a dose-dependent manner. Gen increased the portion of HeLa cells in S phase and decreased the port...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hai-Hong Chen, Shu-Ping Chen, Qiu-Ling Zheng, Shao-Ping Nie, Wen-Juan Li, Xiao-Juan Hu, Ming-Yong Xie Tags: Research Paper Source Type: research

The Clinicopathological Features and Survival Outcomes of Different Histological Subtypes in Triple-negative Breast Cancer
Conclusions: TNBC histological subtypes have different clinicopathological characteristics and survival outcomes. Medullary carcinoma and apocrine adenocarcinoma have excellent prognosis; mixed lobular-ductal carcinoma and metaplastic carcinoma are the most aggressive subtypes. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hong-Ye Liao, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, San-Gang Wu Tags: Research Paper Source Type: research

Capn4 overexpression indicates poor prognosis of ovarian cancer patients
This study aimed to investigate clinical role of Capn4 in ovarian cancer. The expression of Capn4 in 113 ovarian cancer and 35 non-tumor tissue samples were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Capn4 expression was significantly upregulated in ovarian cancer tissues compared with non-tumor tissues (p
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ming-Fang Yang, Yuan-Lei Lou, Si-Sun Liu, Shan-Shan Wang, Chun-Hua Yin, Xiao-Hua Cheng, Ou-Ping Huang Tags: Research Paper Source Type: research

Potent peptide-conjugated silicon phthalocyanines for tumor photodynamic therapy
Phthalocyanines (Pcs) are a group of promising photosensitizers for use in photodynamic therapy (PDT). However, their extremely low solubility and their strong tendency to aggregate in aqueous solution greatly restrict their application. Conjugation of Pc macrocycles with peptide ligands could be a very useful strategy to optimize the physical properties of Pcs not only by increasing their water solubility and reducing their aggregation but also by endowing the conjugates with a tumor-targeting capability. To develop highly potent photosensitizers for tumor PDT, we prepared new peptide-conjugated photosensitizers using sil...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qian Liu, Mingpei Pang, Sihai Tan, Jin Wang, Qingle Chen, Kai Wang, Wenjie Wu, Zhangyong Hong Tags: Research Paper Source Type: research

Positive Expression of SMYD2 is Associated with Poor Prognosis in Patients with Primary Hepatocellular Carcinoma
Purpose: SET and MYND domain-containing protein2 (SMYD2), a histone lysine methyltransferases, is a candidate human oncogene in multiple tumors. However, the expression dynamics of SMYD2 in hepatocellular carcinoma (HCC) and its clinical/prognostic significance are unclear.Methods: The SMYD2 expression profile was examined by quantitative real-time polymerase chain reaction (qRT-PCR), and immunohistochemistry (IHC) in HCC tissues and matched adjacent non-tumorous tissues. SMYD2 was silenced in HCC cell lines to determine its role in tumor proliferation and cell cycle progression, and the possible mechanism. Spearman's rank...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shan-Ru Zuo, Xiao-Cong Zuo, Yang He, Wei-Jin Fang, Chun-Jiang Wang, Heng Zou, Pan Chen, Ling-Fei Huang, Li-Hua Huang, Hong Xiang, Shi-Kun Liu Tags: Research Paper Source Type: research

MiR-378 and MiR-1827 Regulate Tumor Invasion, Migration and Angiogenesis in Human Lung Adenocarcinoma by Targeting RBX1 and CRKL, Respectively
MicroRNAs (miRNAs) have been extensively studied over the decades and have been proposed as potential molecular targets for cancer treatment. Studies have shown that miR-378 participates in numerous biological processes in various cancers; whereas miR-1827 has only been reported in pediatric glioma. The mechanism of how miRNAs modulate lung cancer metastasis remains unclear. Our previous study demonstrated that miR-378 is up-regulated while miR-1827 is down-regulated in high invasive lung cancer sub-cell lines, and their biological functions have been described. Here, we report that miR-378 and miR-1827 modulate lung cance...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chai San Ho, Suzita Mohd Noor, Noor Hasima Nagoor Tags: Research Paper Source Type: research

Keratin17 Promotes Tumor Growth and is Associated with Poor Prognosis in Gastric Cancer
Krt17 is a 48kDa protein member of keratin family. Previous literatures have demonstrated Krt17 may play a promotive role in the progression of various malignancies. However, the exact function of Krt17 in the carcinogenesis and the progression of gastric cancer (GC) remains unknown. In the present study, the expression of Krt17 in 20 fresh GC and matched normal tissues were detected and Krt17 was found to be significantly increased in GC tissues compared to normal tissues. And then the immunochemistry was performed to investigate the Krt17 expression in 569 GC tissue specimens, we found that the expression of Krt17 was re...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hao Hu, Dan-hua Xu, Xiao-xu Huang, Chun-chao Zhu, Jia Xu, Zi-zhen Zhang, Gang Zhao Tags: Research Paper Source Type: research

Clinical Significance of Glycoprotein Non-metastatic B and Its Association with EGFR/HER2 in Gastrointestinal Cancer
Glycoprotein non-metastatic B (GPNMB), a type I transmembrane glycoprotein, is overexpressed in melanoma and breast cancer and promotes cancer-cell invasion and motility. We previously reported cross-talk between GPNMB and human epidermal growth factor receptor 2 (HER2) in breast cancer, suggesting that GPNMB might play an important role in resistance to anti-HER2 therapy in breast cancer. Here, we clarified the association between GPNMB and HER-family proteins in gastrointestinal cancer by examining their relationships using gastric and colorectal cancer cell lines. We found that GPNMB depletion of by small-interfering RN...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jesse Yu Tajima, Manabu Futamura, Siqin Gaowa, Ryutaro Mori, Toshiyuki Tanahashi, Yoshihiro Tanaka, Nobuhisa Matsuhashi, Takao Takahashi, Kazuya Yamaguchi, Tatsuhiko Miyazaki, Kazuhiro Yoshida Tags: Research Paper Source Type: research

Antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resistant lung cancer cells
The present study investigated whether antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes can enhance the killing effect of CD8+ cytotoxic T lymphocytes (CTLs) on lung stem-like cancer cells (SLCCs). The CTLs were generated using an accelerated co-cultured dendritic cells (DC) (acDC) assay by incubating human peripheral blood mononuclear cells (PBMCs) from non-small-cell lung cancer patients with antigen peptides of Oct4 and Sox2 in the presence of several DC-activating agents. CD154+ NIH3T3 cells prepared by CD154 lentiviral transfection were used as feeder layer to activate primary B cell...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Xueyan Zhang, Yanwei Zhang, Jianlin Xu, Huimin Wang, Xiaoxuan Zheng, Yuqing Lou, Baohui Han Tags: Research Paper Source Type: research

miR-149 in Human Cancer: A Systemic Review
MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers and expect to lay the foundation for future works on this important microRNA. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yunjie He, Dandan Yu, Lingping Zhu, Shanliang Zhong, Jianhua Zhao, Jinhai Tang Tags: Review Source Type: research

Long noncoding RNA H19 derived miR-675 regulates cell proliferation by down-regulating E2F-1 in human pancreatic ductal adenocarcinoma
In this study, we investigated the expression of miR-675 in PDAC tumours and cells, the biological function of miR-675 in PDAC cell proliferation and the possible relationship among H19, miR-675 and E2F-1. As a transcript of the first exon of H19, the level of miR-675 was negatively correlated with H19 expression in microdissected PDAC tissues (r=-0.0646, P=0.001). The serum miR-675 expression was significantly down-regulated in patients with PDAC compared to those in healthy individuals. Moreover, an evaluation of five PDAC cases showed that there was a remarkable increase of serum miR-675 levels after resection of the pr...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ling Ma, Xiaodong Tian, Huahu Guo, Zhengkui Zhang, Chong Du, Feng Wang, Xuehai Xie, Hongqiao Gao, Yan Zhuang, Marko Kornmann, Hong Gao, Yinmo Yang Tags: Research Paper Source Type: research

Identification of Biomarker for Cutaneous Squamous Cell Carcinoma Using Microarray Data Analysis
Cutaneous squamous cell carcinoma (CSCC) is one of the most malignant tumors worldwide. We aimed to explore the molecular mechanism of this CSCC and screen feature genes that can function as the biomarker of CSCC and thus provide a theoretical basis for the pathogenesis research and development of medicine. The method of microarray data analysis was used in this study to explore the differentially expressed genes between tissues of normal specimens and tissues of patients with CSCC. Besides, functional enrichment analysis and signal pathway were performed on these genes to screen the feature genes that are closely associat...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wei Wei, Yan Chen, Jie Xu, Yu Zhou, Xinping Bai, Ming Yang, Ju Zhu Tags: Research Paper Source Type: research

Role of miR-483 in digestive tract cancers: from basic research to clinical value
Digestive tract cancers (DTCs) is the most common malignant tumors in the world. Despite surgery and medical technology have witnessed the increasing development and sharp advancement in the past decade, DTCs remain a critical concern with high morbidity and mortality. Since a class of small noncoding RNAs termed miRNAs were identified several years ago, increasing studies have attempted to illustrate the relationship between the specific miRNAs dysregulated expression levels and the diseases phenotypic changes. For example, microRNA-483 (miR-483) aberrant expression plays a pivotal part in tumor biology in a variety of hu...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wei Zhou, Wanli Yang, Jiaojiao Ma, Hongwei Zhang, Zeng Li, Lei Zhang, Jinqiang Liu, Zhenyu Han, Hu Wang, Liu Hong Tags: Review Source Type: research

GP73 level determines chemotherapeutic resistance in human hepatocellular carcinoma cells
Conclusion The expression level of GP73 is critical for the resistance of OXA in HCC cell lines. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jia-Zhou Ye, Shu-mei Yan, Chun-ling Yuan, Hui-ni Wu, Jin-yan Zhang, Zhi-Hui Liu, Yong-Qiang Li, Xiao-Ling Luo, Yan Lin, Rong Liang Tags: Research Paper Source Type: research

Limb-bud and Heart Overexpression Inhibits the Proliferation and Migration of PC3M Cells
Conclusions: Our results reveal that LBH expression is down-regulated in the tissue and cell lines of PCa. LBH overexpression inhibits PC3M cell proliferation and tumor growth by inducing cell cycle arrest through down-regulating cyclin D1and cyclin E2 expression. LBH might be a therapeutic target and potential diagnostic marker in PCa. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qicai Liu, Ermao Li, Long Huang, Minsheng Cheng, Li Li Tags: Research Paper Source Type: research

Prophylactic cranial irradiation in resected small cell lung cancer: A systematic review with meta-analysis
Conclusions: PCI might be associated with a favorable survival advantage and reduced BM risk in complete resected SCLC patients, except for p-stage I patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yang Yang, Danhong Zhang, Xia Zhou, Wuan Bao, Yonglin Ji, Liming Sheng, Lei Cheng, Ying Chen, Xianghui Du, Guoqin Qiu Tags: Research Paper Source Type: research

In Vivo Double Targeting of C26 Colon Carcinoma Cells and Microenvironmental Protumor Processes Using Liposomal Simvastatin
Conclusion: Our data proved that LCL-SIM antitumor activity in C26 colon carcinoma was based on cytotoxic effects on these cancer cells and suppressive actions on tumor angiogenesis and inflammation. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Lavinia Luput, Emilia Licarete, Denise Minerva Drotar, Andras-Laszlo Nagy, Alina Sesarman, Laura Patras, Valentin Florian Rauca, Alina Porfire, Dana Muntean, Marcela Achim, Ioan Tomuta, Laurian Vlase, Cornel Catoi, Nicolae Dragos, Manuela Banciu Tags: Research Paper Source Type: research

The Unknown microRNA Expression of Male Breast Cancer. Similarities and Differences with Female Ductal Carcinoma. Their Role as Tumor Biomarker
Conclusions: These results suggest that MBC has a unique expression profile compared to normal breast tissue and expression profile of female breast cancer. Differentially expressed miRNAs provide insights of this uncommon but highly aggressive pathology. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Maria J Merino, Sara Gil, Carmen Garcia Macias, Karlena Lara Tags: Research Paper Source Type: research

MK2 and ETV1 Are Prognostic Factors in Esophageal Adenocarcinomas
Discussion. Expression of MK2 and ETV1 are prognostic factors in patients, with esophageal adenocarcinoma. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Gerd Jomrich, Florian Maroske, Jasmin Stieger, Matthias Preusser, Ayseg ü l Ilhan-Mutlu, Daniel Winkler, Ivan Kristo, Matthias Paireder, Sebastian Friedrich Schoppmann Tags: Research Paper Source Type: research

Exploration of Racial Differences in Reproductive Factors for Breast Cancer among Women aged 55-74
Conclusions We concluded that different races/ethnicities had different breast cancer related reproductive risk factors. Non-Hispanic Caucasians had the most breast cancer related reproductive risk factors, while the minorities had none or few breast cancer related reproductive risk factors and among these few factors only 1 was also risk factor for non-Hispanic Caucasians. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Chuanbo Xie, Nan Shao, Longjun He, Xiuhong Li, Cong Li, Jibin Li, Dongfang Su Tags: Research Paper Source Type: research

Clinicopathological Characteristics of the primary and metastatic Hepatic Neuroendocrine Tumors and the relevant Prognosis-Related Factors: A Retrospective Study of 81 Cases in a Single Chinese Center
Aims: We aim to describe the clinicopathological characteristics of hepatic neuroendocrine tumors (HNETs) and evaluate the relevant prognosis-related factors.Methods: The clinical data of 81 consecutive patients with primary or metastatic HNETs from March 2000 to July 2014 were retrospectively analyzed.Results: The mean (SD) age was 59.68 (11.64) years, 69.15% were men. The percentages of Grade G1, G2 and G3 tumors were 4.94%, 25.93% and 69.13%, respectively. Thirty-five cases were primary HNETs. Primary HNETs were more common in patients with larger tumors, lymph nodes invasions, tumor necrosis and portal vein tumor throm...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yang Lv, Cheng Huang, Haizhou Xu, Xu Han, Lei Zhang, Weilin Mao, Yuan Ji, Dayong Jin, Wenhui Lou, Xuefeng Xu Tags: Research Paper Source Type: research

Influence of diabetes on the risk of urothelial cancer according to body mass index: a 10-year nationwide population-based observational study
To examine the association between obesity and urothelial cancer, we used a representative data from the National Health Insurance System (NHIS). Participants included 826,170 men aged 20 years and older who experienced a health examination at least one time between 2004 and 2008. The study thus excluded people aged
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Woong Jin Bae, Jin Bong Choi, Hyong Woo Moon, Young Hyun Park, Hyuk Jin Cho, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Kyung-Do Han, U-Syn Ha Tags: Research Paper Source Type: research

Clinical significance and diagnostic capacity of serum TK1, CEA, CA 19-9 and CA 72-4 levels in gastric and colorectal cancer patients
In this study, we explore the diagnostic value of joint detection of thymidine kinase 1 (TK1), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9) and carbohydrate antigen 72-4 (CA 72-4) in the diagnosis of GC and CRC, and to evaluated the relationship between TK1 expression and clinical pathological characteristics in the patients. Serum TK1, CA 19-9, CA 72-4 and CEA levels were measured in 169 patients with GC, 344 patients with CRC and 75 healthy controls using electro-chemiluminescence. The TK1 concentration was significantly higher in patients with cancer than in healthy controls and patients with clin...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shufang Ning, Wene Wei, Jilin Li, Bingbing Hou, Jianhong Zhong, Yuxuan Xie, Haizhou Liu, Xianwei Mo, Jiansi Chen, Litu Zhang Tags: Research Paper Source Type: research

Recombinant nanocomposites by the clinical drugs of Abraxane ® and Herceptin ® as sequentially dual-targeting therapeutics for breast cancer
Breast cancer greatly threatens the health of women all over the word despite of several effective drugs. Targeted therapy for breast cancer is limited to human epidermal growth factor receptor 2 (HER2). Herceptin®, monoclonal antibody against HER2, is now widely used in HER2(+) breast cancer. Abraxane®, the current gold standard for paclitaxel (PTX) delivery, has shown superiority in breast cancer based on nanoparticle albumin bound technology. Despite these advances, further novel targeted therapy with more improved anti-tumor efficacy for breast cancer is still urgently needed. Here, we report the recombinant na...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shuang Ding, Jian Xiong, Dan Lei, Xiao-li Zhu, Hai-jun Zhang Tags: Research Paper Source Type: research

Elevated baseline serum lactate dehydrogenase indicates a poor prognosis in primary duodenum adenocarcinoma patients
Purpose: Tumour cells produce energy through glycolysis and lactate dehydrogenase (LDH) is a key part of glycolysis. Elevation of serum LDH may indicate poor prognosis in primary duodenum adenocarcinoma. We aim to explore the prognostic significance of LDH in this disease.Methods and materials: Two hundred forty-four patients diagnosed with primary duodenum adenocarcinoma who were treated at the Sun Yat-sen Cancer Center from February 1996 to January 2016 were retrospectively analysed. We collected routine clinical data, including baseline LDH. Patients were classified into a normal LDH group (≤ 245U/L) and higher LDH g...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Zhan-hong Chen, Miao-zhen Qiu, Xiang-yuan Wu, Qi-nian Wu, Jia-huan Lu, Zhao-lei Zeng, Yun Wang, Xiao-li Wei, Feng Wang, Rui-hua Xu Tags: Research Paper Source Type: research

Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
Molecule interacting with CasL 2 (MICAL2), a microtubule associated monooxygenase, is involved in cell growth, axon guidance, vesicle trafficking and apoptosis. Recent studies have demonstrated that MICAL2 is highly expressed in tumor and accelerates tumor progression and it is deemed to be a novel tumor-promoting factor. MICAL2 overexpression increases cell proliferation to accelerate tumor growth, and MICAL2 also promotes epithelial-mesenchymal transition (EMT)-related proteins to increase cancer cell metastasis. On mechanism, MICAL2 induces EMT by regulating SRF (serum response factor)/MRTF-A (myocardin related transcri...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yongqiang Cai, Jinping Lu, Faqing Tang Tags: Review Source Type: research

Impact of Weight Loss at Presentation on Survival in Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKI) Sensitive Mutant Advanced Non-small Cell Lung Cancer (NSCLC) Treated with First-line EGFR-TKI
Purpose The aim of this study is to evaluate the impact of weight loss at presentation on treatment outcomes of first-line EGFR-tyrosine kinase inhibitors (EGFR-TKI) in EGFR-TKI sensitive mutant NSCLC patients.Methods We retrospectively analyzed the clinical outcomes of 75 consecutive advanced NSCLC patients with EGFR-TKI sensitive mutations (exon 19 deletion or exon 21 L858R) received first-line gefitinib or erlotinib therapy according to weight loss status at presentation in our single center.Results Of 75 EGFR-TKI sensitive mutant NSCLC patients, 49 (65.3%) patients had no weight loss and 26 (34.7%) had weight loss at p...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Liping Lin, Juanjuan Zhao, Jiazhu Hu, Fuxi Huang, Jianjun Han, Yan He, Xiaolong Cao Tags: Research Paper Source Type: research

Association between NEFL Gene Polymorphisms and Neuroblastoma Risk in Chinese Children: A Two-Center Case-Control Study
Neuroblastoma is a lethal tumor that mainly occurs in children. To date, the genetic etiology of sporadic neuroblastoma remains obscure. A previous study identified three neuroblastoma susceptibility loci (rs11994014 G>A, rs2979704 T>C, rs1059111 A>T) in neurofilament light (NEFL) gene. Here, we attempted to evaluate the contributions of these three single nucleotide polymorphisms to neuroblastoma susceptibility in Chinese children. We genotyped these three polymorphisms using subjects from Guangdong province (256 cases and 531 controls) and Henan province (118 cases and 281 controls). Logistic regression models w...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Qiang Wu, Zhen-Jian Zhuo, Jixiao Zeng, Jiao Zhang, Jinhong Zhu, Yan Zou, Ruizhong Zhang, Tianyou Yang, Deli Zhu, Jing He, Huimin Xia Tags: Research Paper Source Type: research

Identification of Kininogen 1 as a Serum Protein Marker of Colorectal Adenoma in Patients with a Family History of Colorectal Cancer
The serum protein markers of colorectal adenoma in patients with a family history of colorectal cancer have been rarely reported. Serum samples from colorectal adenoma patients with or without a family history of colorectal cancer and healthy controls were profiled using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS). The model to distinguish colorectal adenoma patients with a family history of colorectal cancer from atypical hereditary colorectal families (CRA-H) and sporadic colorectal adenoma patients without a family history of colorectal cancer (CRA-S) was established with ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jiekai Yu, Yanqin Huang, Chen Lin, Xiaofen Li, Xuefeng Fang, Chenhan Zhong, Ying Yuan, Shu Zheng Tags: Research Paper Source Type: research

Clinical study on the prevalence and comparative analysis of metabolic syndrome and its components among Chinese breast cancer women and control population
This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its components in the breast cancer (605 cases) and control population (3212 cases), from Breast Cancer Center and Physical Examination Center of Chongqing, China, from July 2015 to February 2017, were collected for comparative analysis. This study was prospectively registered in Chinese Clinical Trial Registry (http://www.chictr.org.cn/, number: ChiCTR-OOB-15007543). The prevalence of metabolic syndrome in breast cancer (32.6%) was obviously ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yu-tuan Wu, Qing-qing Luo, Xin Li, Bilal Arshad, Zhou Xu, Liang Ran, Chun-xia Zhao, He Wu, Yan-ling Shi, Hao-ran Chen, Hao Li, Hong-yuan Li, Kai-nan Wu, Ling-quan Kong Tags: Research Paper Source Type: research

The prognostic value of Niemann-Pick C1-like protein 1 and Niemann-Pick disease type C2 in hepatocellular carcinoma
Conclusion: NPC1L1 and NPC2 were lowly expressed in HCC compared with peritumoral liver tissues, and low expression of NPC1L1 and NPC2 in HCC tissues may indicate poor outcome of HCC patients after surgery. NPC1L1/NPC2 combination is an independent prognostic factor for OS and TTR in postoperative HCC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ke-Ji Chen, Ri-Ming Jin, Chun-Chao Shi, Rui-Liang Ge, Lei Hu, Qi-Fei Zou, Quan-Yu Cai, Guang-Zhi Jin, Kui Wang Tags: Research Paper Source Type: research

Folic acid-modified diatrizoic acid-linked dendrimer-entrapped gold nanoparticles enable targeted CT imaging of human cervical cancer
In this study, we developed folic acid (FA) gold nanoparticles (AuNPs) through diatrozic acid (DTA) linking for in vitro and in vivo targeted imaging of HeLa cervical cancer cells by computed tomography (CT). G5 dendrimers were used as templates to synthesize AuNPs within the interiors of dendrimers. The synthesized AuNPs were then sequentially modified by fluorescein isothiocyanate, FA, and DTA and the remaining terminal amines on the dendrimers were acetylated. We further performed hematoxylin and eosin staining, cell viability assay, flow cytometric analysis of cell cycle and apoptosis, and hemolytic assay to examine th...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jiaying Lin, Weiwei Hu, Fengli Gao, Jinbao Qin, Chen Peng, Xinwu Lu Tags: Research Paper Source Type: research

Down-expression of CD36 in pancreatic adenocarcinoma and its correlation with clinicopathological features and prognosis
This study is aimed to explore the expression of CD36 in pancreatic cancer and corresponding non-tumor normal tissues, and its correlation with clinicopathological features and prognosis of pancreatic cancer patients. By analyzing the chip results of database GSE16515, we found that there was significant differential expression of CD36 in pancreatic cancer and corresponding non-tumor normal tissues. In this study, western blot and immunohistochemistry were used to show that the expression of CD36 in pancreatic cancer cells and tissues is significantly lower than that in corresponding non-tumor normal tissues. By statistica...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shengnan Jia, Liangjing Zhou, Tao Shen, Senhao Zhou, Guoping Ding, Liping Cao Tags: Research Paper Source Type: research

Role of Postoperative Concurrent Chemoradiotherapy for Esophageal Carcinoma: A meta-analysis of 2165 Patients
Conclusions: This meta-analysis based on the largest-scale of published literature confirms that post-CCRT yields significant survival benefit and improves local-regional control with tolerable toxicity for patients with esophageal carcinoma. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jingjing Kang, Joe Y. Chang, Xin Sun, Yu Men, Hongmei Zeng, Zhouguang Hui Tags: Research Paper Source Type: research

Additional induction chemotherapy to concurrent chemotherapy and intensity-modulated radiotherapy with or without nimotuzumab in first-line treatment for locoregionally advanced nasopharyngeal carcinoma: a propensity score matched analysis
Conclusions: Nimotuzumab is an effective treatment option for locoregionally advanced nasopharyngeal carcinoma, and the addition of induction chemotherapy to concurrent chemoradiotherapy and nimotuzumab could obtain the best survival benefits. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Fangzheng Wang, Quanquan Sun, Chuner Jiang, Tongxin Liu, Aizawa Rihito, Sakamoto Masoto, Yuezhen Wang, Zhenfu Fu, Ming Chen Tags: Research Paper Source Type: research

Differential expression and clinical significance of epithelial-mesenchymal transition markers among different histological types of triple-negative breast cancer
This study aimed to investigate the role of EMT in metaplastic carcinoma.Methods: E-cadherin, Slug, Twist and Vimentin levels were detected by immunohistochemistry in 167 TNBC tumors, including 145 invasive carcinomas of no special type (ICONSTs), 14 spindle cell carcinomas (SpCCs) and 8 matrix-producing carcinomas (MPCs).Results: Nuclear Slug and Twist were more frequently detected in SpCC and MPC tumors than that in ICONST tumors (p
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shuling Zhou, Xiangjie Sun, Lin Yu, Ruoji Zhou, Anqi Li, Ming Li, Wentao Yang Tags: Research Paper Source Type: research

The role of cancer-associated fibroblast MRC-5 in pancreatic cancer
Conclusion: MRC-5 limits the malignant activities of PC cells by suppressing cancer stem cell expansion, remolding epithelial polarity, and blocking the protumoral cascade reaction coupled to TLR4, TLR1, CD14, and CD25. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Song-Ming Ding, Ai-Li Lu, Wu Zhang, Lin Zhou, Hai-Yang Xie, Shu-Sen Zheng, Qi-Yong Li Tags: Research Paper Source Type: research