The Inhibitory Effects of Recombinant Hespintor Combined with Sorafenib on Transplanted Human Hepatoma in Nude Mice, and Transcriptional Regulation of Hespintor Based on RNA-Seq
Conclusions: The antitumor effect of Hespintor combined with Sorafenib in treating the subcutaneously implanted hepatocellular carcinoma tumors in nude mice was significant. The possible transcriptional regulation by Hespintor involved multiple signaling pathways, and it was not just the antitumor effect of uPA via its extracellular inhibitions. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yong-Zhi Lun, Jie Sun, Ben Liu, Wen Dong, Ling-Hong Pan, Jian Lin, Jing-Xia Zhang Tags: Research Paper Source Type: research
Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer
This study aimed to conduct a scientometric analysis of cAMP signaling system in cancer field, and explored the research trend, hotspots and frontiers from the past decade. Relevant literatures published from 2009 to 2019 were collected in the Web of Science Core Collection database. EndNote X9 was used to remove duplicate articles, and irrelevant articles were manually filtered. Bibliometric analyses were completed by CiteSpace V. A total of 4306 articles were included in this study. The number of related literatures published each year is gradually increasing. Most of them belong to “Biochemistry & Molecular Bi...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Caoli Tang, Duanya Liu, Yongsheng Fan, Jun Yu, Cong Li, Jianmei Su, Chunhong Wang Tags: Research Paper Source Type: research
Characterization of a new human astrocytoma cell line SHG140: cell proliferation, cell phenotype, karyotype, STR markers and tumorigenicity analysis
Conclusions: Our study showed that SHG140 was an astrocytoma glioma continuous cell line derived from a human adult male, having a strong tumorigenicity in nude mice, which made it wound be a useful model for the study of human glioblastoma multiforme. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yanyan Li, Ting Sun, Zhi Chen, YunXiang Shao, Yulun Huang, Youxin Zhou Tags: Research Paper Source Type: research
The Effect of Neoadjuvant Therapies for Patients with Locally Advanced Gastric Cancer: A Propensity Score Matching Study
Conclusions: In conclusion, NAT improved survival outcomes among LAGC patients over surgery followed by adjuvant chemotherapy. In comparison with nCT, nCRT resulted in higher pCR rate, better DFS and LRFS, without significantly affecting OS. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Tongbo Wang, Yingtai Chen, Lulu Zhao, Hong Zhou, Chaorui Wu, Xiaojie Zhang, Aiping Zhou, Jing Jin, Dongbing Zhao Tags: Research Paper Source Type: research
Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1
In a meta-analysis, the long noncoding RNA cancer susceptibility candidate 8 (CASC8) was found to be a cancer susceptibility gene closely related to lung cancer, but its functions in lung cancer are unknown. In the Cancer Genome Atlas database, the expression of CASC8 was significantly higher in non-small cell lung cancer than in adjacent normal tissues, and high expression of CASC8 was associated with poor prognosis in patients with lung adenocarcinoma. Silencing CASC8 inhibited proliferation, migration, and invasion in non-small cell lung cancer cell lines. Silencing CASC8 also promoted sensitivity to osimertinib through...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xizi Jiang, Jingqian Guan, Yitong XU, Hongjiu Ren, Jun Jiang, Muli Wudu, Qiongzi Wang, Hongbo SU, Yao Zhang, Bo Zhang, Zifang Zou, Yujiao Hu, Xiaodan SUN, Xueshan Qiu Tags: Research Paper Source Type: research
Association of Preoperative Serum Carcinoembryonic Antigen and Gastric Cancer Recurrence: A Large Cohort Study
Conclusions: Patients with elevated preoperative CEA are at increased risk for recurrence, especially within the first 24 months after surgery. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Qinbo Cai, Wen Zhou, Jin Li, Xinde Ou, Chuangqi Chen, Shirong Cai, Weiling He, Jianbo Xu, Yulong He Tags: Research Paper Source Type: research
USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer
In this study, we had examined the biological role of USP43 in colorectal cancer. USP43 protein and mRNA abundance in clinical tissues and five cell lines were analyzed with quantitative real-time PCR test (qRT-PCR) and western blot. USP43 overexpression treated DLD1 cells and USP43 knockdown treated SW480 cells were used to study cell proliferation, migration, colony formation, invasion, and the expression of epithelial-mesenchymal transformation (EMT) biomarkers. Moreover, ubiquitination related ZEB1 degradation was studied with qRT-PCR and western blot. The relationships between USP43 and ZEB1 were investigated with wes...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Dao-xiong Ye, Si-si Wang, Ying Huang, Xiao-jie Wang, Pan Chi Tags: Research Paper Source Type: research
Adding Adjuvants to Fluoropyrimidine-based Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: An Option Worthy of Serious Consideration
The application of fluoropyrimidine-based neoadjuvant chemoradiotherapy (Fu-nCRT) of locally advanced rectal cancer (LARC) has become a common therapeutic regimen. In order to improve the efficacy and enable more patients to benefit from this treatment, an accumulation of studies have been carried out on the auxiliary use of other drugs with Fu-nCRT. However, due to specific challenges and the potential opportunities that coexist in this field, a more reasonable approach to the mode of treatment remains to be explored. In this review, we have summarized the results of the studies on the combination of Fu-nCRT with cytotoxi...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Fengpeng Wu, Chaoxi Zhou, Bingyuan Wu, Xiaoxiao Zhang, Kanghua Wang, Jun Wang, Linlin Xiao, Guiying Wang Tags: Review Source Type: research
Long noncoding RNA DLEU2 affects the proliferative and invasive ability of colorectal cancer cells
This study sought to investigate the effects of DLEU2 on CRC pathogenesis, and the underlying mechanism involved. Using a quantitative real-time polymerase chain reaction (qRT-PCR) assay, we demonstrated that the expression levels of DLEU2 in 45 pairs of CRC tissues were higher than those in the corresponding normal colon mucosal tissues. In addition, CRC patients with high DLEU2 expression levels exhibited poor overall survival (OS) and recurrence-free survival (RFS), as determined by analyses and measurements from the GEO and GEPIA databases. When DLEU2 was silenced using short interfering RNA (siRNA) in CRC cell line, t...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xiaoyun He, Bingbing Yu, Gaoyan Kuang, Yongrong Wu, Meili Zhang, Pengfei Cao, Chunlin Ou Tags: Research Paper Source Type: research
Whole-exome Sequencing of Prostate Cancer in Sardinian Identify Recurrent UDP-glucuronosyltransferase Amplifications
Globally, prostate cancer is the third most common cancer in the world, and the second most common cancer in men. However, rates for incidence and mortality vary considerably with race, ethnicity, and geography. Over 97 significantly mutated genes that have been identified in prostate cancer; however, a lack of genomic prostate cancer studies focusing on different racial and ethnic groups and racial mixing pose a serious challenge to universalize these findings. The Sardinian population is an isolated Mediterranean population that has a high frequency of centenarians and a much lower incidence of prostate cancer than found...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Tiansheng Zeng, Maria Antonietta Fedeli, Francesco Tanda, Yuyong Wang, Dongsheng Yang, Bei Xue, Lisha Jia, Giuseppe Palmieri, Leonardo A Sechi, David J. Kelvin Tags: Research Paper Source Type: research
Research progress of radiation-induced hypothyroidism in head and neck cancer
This paper reviews the factors related to hypothyroidism after radiotherapy in patients with head and neck cancer to facilitate the prevention of radiation-induced hypothyroidism and reduce its incidence. Hypothyroidism is a common complication after radiotherapy in patients with head and neck cancer, wherein the higher the radiation dose to the thyroid and pituitary gland, the higher the incidence of hypothyroidism. With prolonged follow-up time, the incidence of hypothyroidism gradually increases. Intensity modulated radiotherapy should limit the dose to the thyroid, which would reduce the incidence of hypothyroidism. In...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Ling Zhou, Jia Chen, Chang-Juan Tao, Ming Chen, Zhong-Hua Yu, Yuan-Yuan Chen Tags: Review Source Type: research
Prognostic Factors of Survival with Aflibercept and FOLFIRI (fluorouracil, leucovorin, irinotecan) as Second-line Therapy for Patients with Metastatic Colorectal Cancer
Conclusions: Significant prognostic factors for PFS with aflibercept plus FOLFIRI as second-line therapy were extracted and validated in the multivariate OS model. These findings could provide useful information for selecting patients for aflibercept plus FOLFIRI as second-line therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jinchul Kim, Hana Kim, Jung Yong Hong, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Seung Tae Kim Tags: Research Paper Source Type: research
MUC 15 Promotes Osteosarcoma Cell Proliferation, Migration and Invasion through Livin, MMP-2/MMP-9 and Wnt/ β -Catenin Signal Pathway
Conclusion: The high-expression of MUC15 promotes the proliferation, migration and invasion of osteosarcoma through anti-apoptosis, increasing the invasive ability by epithelial interstitial transition, and activating the Wnt/b-Catenin signal pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Tonglei Chen, Zhenshi Chen, Xiaoning Lian, Weidong Wu, Lei Chu, Shaoru Zhang, Lihui Wang Tags: Research Paper Source Type: research
Differences Related to Cancer Screening by Minority and Rural/Urban Status in the Deep South: Population-based Survey Results
Discussion: Cancer early detection education is needed across Alabama to improve cancer screening, and particularly needed among racial/ethnic minorities to raise cancer awareness. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Casey Daniel, Salma Aly, Sejong Bae, Isabel Scarinci, Claudia Hardy, Mona Fouad, Wendy Demark-Wahnefried Tags: Research Paper Source Type: research
Targeting the CtBP1-FOXM1 transcriptional complex with small molecules to overcome MDR1-mediated chemoresistance in osteosarcoma cancer stem cells
Chemoresistance is a major barrier for the chemotherapy of osteosarcoma. The induction of multidrug resistance protein 1 (MDR1), an ATP-dependent transporter, can efflux anti-cancer drugs, thereby decreasing chemosensitivity. However, an actual involvement of MDR1 in the chemoresistance of osteosarcoma cells has not been established. We obtained two cisplatin (CDDP)-resistant osteosarcoma cancer stem cell (CSC) lines using sphere formation medium supplemented with CDDP. These two CDDP-resistant CSC cell lines showed substantial cell proliferation, colony formation, cell invasion, and in vivo tumor growth in the presence of...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xun Chen, Qian Zhang, Xiaoqian Dang, Tao Song, Yufei Wang, Zirui Yu, Shihui Zhang, Jinzhu Fan, Fei Cong, Wentao Zhang, Ning Duan Tags: Research Paper Source Type: research
