Emerging roles of MiR-133a in human cancers
MicroRNAs (miRNAs) can post-transcriptionally regulate the expression of cancer-relevant genes via binding to the 3'-untranslated region (3'-UTR) of the target mRNAs. MiR-133a, as a miRNA, participate in tumorigenesis, progression, autophagy and drug-resistance in various malignancies. Based on the recent insights, we discuss the functions of miR-133a in physiological and pathological processes and its potential effects on cancer diagnosis, prognosis and therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yu-Ting Hua, Wen-Xiu Xu, Hui Li, Min Xia Tags: Research Paper Source Type: research
Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells
Conclusions: Our results revealed berberine increased the TET3-mediated demethylation and promoted the suppression of miR-145 on HK2 to antagonize the Warburg effect of ovarian cancer cells. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jie Li, Yuliang Zou, Meili Pei, Yun Zhang, Yu Jiang Tags: Research Paper Source Type: research
LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma
Conclusions: The results suggest that LRP1B or TP53 mutations are associated with higher TMB and a poor prognostic factor in HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Longrong Wang, Kai Yan, Xigan He, Hongxu Zhu, Jia Song, Shiqing Chen, Shangli Cai, Yiming Zhao, Lu Wang Tags: Research Paper Source Type: research
The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xuewen Tan, Haifeng Jiang, Yilong Fang, Dafei Han, Yawei Guo, Xinming Wang, Xun Gong, Wenming Hong, Jiajie Tu, Wei Wei Tags: Review Source Type: research
Down-regulation of ACACA suppresses the malignant progression of Prostate Cancer through inhibiting mitochondrial potential
Conclusion: Targeting ACACA gene and mitochondria might serve as a novel therapy for prostate cancer treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Hui Zhang, Shaoyou Liu, Zhouda Cai, Weimin Dong, Jianheng Ye, Zhiduan Cai, Zhaodong Han, Yuxiang Liang, Yangjia Zhuo, Yong Luo, Xuejin Zhu, Yulin Deng, Yixun Zhang, Ren Liu, Yuanfa Feng, Jiarun Lai, Rui Zhou, Huijing Tan, Weide Zhong Tags: Research Paper Source Type: research
Synthesis and evaluation of 68Ga-labeled dimeric cNGR peptide for PET imaging of CD13 expression with ovarian cancer xenograft
Conclusions: 68Ga-DOTA-c(NGR)2 was easily synthesized, and it showed favorable CD13-specific targeting ability by in vitro data and microPET imaging with ovarian cancer xenografts. Collectively, 68Ga-DOTA-c(NGR)2 might be a potential PET imaging probe for non-invasive evaluation of the CD13 receptor expression in tumors. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yi Yang, Jun Zhang, Huifeng Zou, Yang Shen, Shengming Deng, Yiwei Wu Tags: Research Paper Source Type: research
NKCC1 promotes proliferation, invasion and migration in human gastric cancer cells via activation of the MAPK-JNK/EMT signaling pathway
Conclusions: NKCC1 promotes migration and invasion of GC cells by MAPK-JNK/EMT pathway and can be a potential therapeutic target. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jun-fu Wang, Kun Zhao, Ye-yang Chen, Yue Qiu, Jin-hui Zhu, Bo-pei Li, Zheng Wang, Jun-qiang Chen Tags: Research Paper Source Type: research
The Association of Polymorphisms in Base Excision Repair Genes with Ovarian Cancer Susceptibility in Chinese Women: A Two-Center Case-Control Study
Base excision repair (BER) acts upon the most important mechanism of the DNA repair system, protecting DNA stability and integrity from the mutagenic and cytotoxic effects. Multiple researches have indicated that single-nucleotide polymorphisms (SNPs) in the BER-related gene may be associated with the susceptibility of ovarian cancer. However, the results are controversial. In this two-center case-control study, 19 potentially functional SNPs in six BER-related genes (hOGG1, APE1, PARP1, FEN1, LIG3 and XRCC1) was genotyped in 196 ovarian cancer cases and 272 cancer-free controls. And, their associations with ovarian cancer...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Mingyao Zhang, Zhiguang Zhao, Sailing Chen, Zongwen Liang, Jiawei Zhu, Manman Zhao, Chaoyi Xu, Jing He, Ping Duan, Anqi Zhang Tags: Research Paper Source Type: research
Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species
In conclusion, these results indicated that tephrosin could be developed as a potential chemotherapeutic agent for the treatment of human pancreatic cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jie Du, Fan Jiang, Shen-Sheng Xu, Zi-Feng Huang, Li ‐ Li Chen, Li Li Tags: Research Paper Source Type: research
HnRNP-F promotes the proliferation of bladder cancer cells mediated by PI3K/AKT/FOXO1
Our previous study showed that heterogeneous nuclear ribonucleoprotein F (hnRNP-F) could induce epithelial-mesenchymal transition and metastasis in bladder cancer (BC), however, the role and mechanism of hnRNP-F in mediating the proliferative ability of BC cells remain unclear. HnRNP-F promoted the proliferation of BC cells by using BC cell lines and cell counting kit-8 (CCK8), colony formation and flow cytometry assays in vitro. Furthermore, the association of hnRNP-F with the phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) signalling pathway was confirmed by western blotting after bioinformatic analysis. Hn...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Fei Li, Weiwei Xie, Yunze Fang, Kunfeng Xie, Wendong Liu, Lina Hou, Wanlong Tan Tags: Research Paper Source Type: research
Risk-predicted dual nomograms consisting of clinical and ultrasound factors for downgrading BI-RADS category 4a breast lesions - A multiple centre study
Conclusions: A dual-predicted nomogram incorporating clinical factors and imaging characteristics is an applicable model for downgrading the low-risk lesions in BI-RADS category 4a and shows good stability and accuracy, which is useful for decreasing the rate of invasive examinations and surgery. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Zihan Niu, Jia-Wei Tian, Hai-Tao Ran, Wei-Dong Ren, Cai Chang, Jian-Jun Yuan, Chun-Song Kang, You-Bin Deng, Hui Wang, Bao-Ming Luo, Sheng-Lan Guo, Qi Zhou, En-Sheng Xue, Wei-Wei Zhan, Qing Zhou, Jie Li, Ping Zhou, Chun-Quan Zhang, Man Chen, Ying Gu, Jin-F Tags: Research Paper Source Type: research
Predictive value of preoperative lymphocyte-to-monocyte ratio on survival outcomes in bladder cancer patients after radical cystectomy
Conclusions: An independent association was observed between higher pre-operative LMR in BCa patients undergoing RC and significantly better OS and CSS. In addition, a significant improvement in predictive accuracy was observed with LMR inclusion in multiparametric prediction tools. Therefore, LMR may be utilized in pre-operative patient risk stratification to assist in patient counseling and clinical decision making. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Hai Bi, Ye Yan, Dong Wang, Zijian Qin, Guoliang Wang, Lulin Ma, Yi Huang, Jian Lu Tags: Research Paper Source Type: research
TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer
Conclusions: TRIM37 plays a crucial role in tumor malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in GC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Keiji Nishibeppu, Shuhei Komatsu, Jun Kiuchi, Takuma Kishimoto, Yusuke Takashima, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Hitoshi Fujiwara, Hitoshi Tsuda, Eigo Otsuji Tags: Research Paper Source Type: research
Current Progress in CAR-T Cell Therapy for Hematological Malignancies
Immunotherapies, such as monoclonal antibody therapy and checkpoint inhibitor therapy, have shown inspiring clinical effects for the treatment of cancer. Chimeric antigen receptor T (CAR-T) cells therapy was an efficacious therapeutic approach treating hematological malignancies and encouraging results have been achieved. Three kinds of CAR-T cell therapies, Kymriah (tisagenlecleucel), Yescarta (axicabtagene ciloleucel), were approved for clinical application in 2017 and Tecartus (brexucabtagene autoleucel) was approved in 2020. Despite some progress have been made in treating multiple hematologic tumors, threats still rem...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Donglei Han, Zenghui Xu, Yuan Zhuang, Zhenlong Ye, Qijun Qian Tags: Review Source Type: research
A New Method for the Detection of Colorectal Cancer and the Precancerous Lesions: Occult Blood Testing Combination with Promoter Methylation in the Fecal Sample
Conclusion: Our results demonstrate that sDNA-FOBT is a promising method for screening CRC and precancerous lesions in the Chinese population. Further studies are required to validate the results in a larger sample capacity. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Dan-Yang Wang, Kang-Xin He, Ying Huang, Qin-Qin Lou, Ti He, Xiao Xu Tags: Research Paper Source Type: research
