Functional Polymorphisms in hOGG1 Gene and Neuroblastoma Risk in Chinese Children
Neuroblastoma is a lethal tumor of the sympathetic nervous system. 8-Hydroxydeoxyguanine (8-OH-dG) formation is a common seen type of oxidative DNA damage, which could be repaired by human oxoguanine glycosylase 1 (hOGG1). To explore the contributing role of hOGG1 gene single nucleotide polymorphisms (SNPs) in neuroblastoma risk, we performed a case-control study by genotyping three SNPs (rs1052133 G>C, rs159153 T>C, rs293795 A>G) in hOGG1 gene. A total of 512 neuroblastoma cases and 1076 cancer-free controls were enrolled from three medical centers in China. The hOGG1 gene polymorphisms were determined using TaqM...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yi-Zhen Wang, Zhen-Jian Zhuo, Yuan Fang, Lin Li, Jiao Zhang, Jing He, Xue-Mei Wu Tags: Research Paper Source Type: research

Oxymatrine Synergistically Potentiates the Antitumor Effects of Cisplatin in Human Gastric Cancer Cells
In this study, we explored the chemo-sensitization of OMT to potentiate the anti-tumor effect of CDDP. GC cell lines were dealt with OMT and/or CDDP and then subjected to different experimental methods. We found that OMT could significantly potentiate the CDDP-caused BGC-823 and SGC7901 cells viability loss, and OMT acts synergistically with CDDP. The combinative treatment could arrest cell cycle in G0/G1 phase by increasing p21, p27 and decreasing cyclin D1, and induced apoptosis by ROS generation and AKT/ERK inactivation. Inhibition of ROS respectively reversed the cell death induced by OMT and/or CDDP, suggesting the pi...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yan Liu, Lei Qin, Tingting Bi, Wei Dai, Wei Liu, Quangen Gao, Genhai Shen Tags: Research Paper Source Type: research

The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells
Background: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy treatment. Previously, we showed that stearidonic acid (SDA), an omega-3 fatty acid, enhances the cytotoxicity of doxorubicin (DOX) in human PCa cells. This observation suggests that PCa therapies using SDA and chemotherapeutic drugs in combination offer attractive possibilities for developing treatments that ame...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Mahmoud Mansour, Sabrina van Ginkel, John C. Dennis, Brandon Mason, Isra Elhussin, Kodye Abbott, Satyanarayana R Pondugula, Temesgen Samuel, Edward Morrison Tags: Research Paper Source Type: research

Prognosis Analysis of Histone Deacetylases mRNA Expression in Ovarian Cancer Patients
In conclusion, HDACs may play a crucial role in the prognosis of ovarian cancer, but it is worth noting that HDAC11 may be a biomarker for poor prognosis in ovarian cancer patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Lulu Zhou, Xiaohui Xu, Hailing Liu, Xiaoli Hu, Wenwen Zhang, Miaomiao Ye, Xueqiong Zhu Tags: Research Paper Source Type: research

Efficacy and Safety of Ipilimumab plus Chemotherapy for Advanced Lung Cancer: A Systematic Review and Meta-Analysis
Lung cancer is the leading cause of cancer-related deaths worldwide, with poor prognosis in advanced lung cancer patients. Platinum-based chemotherapy has always been a first-line treatment for the majority of advanced lung cancer patients, but its long-term survival benefit is limited. Ipilimumab is an immune drug that targets the CTLA-4 protein in T cells. Therefore, we evaluated the efficacy and safety of adding ipilimumab to simple chemotherapy for patients with advanced lung cancer. We searched literatures in PubMed, Web of Science, EMBASE, the Cochrane Library and cliniclatrials.gov. The primary end points of this as...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hongman Zhang, Jie Shen, Lilan Yi, Wei Zhang, Peng Luo, Jian Zhang Tags: Research Paper Source Type: research

Systematic Analysis of Gene Expression Alteration and Co-Expression Network of Eukaryotic Initiation Factor 4A-3 in Cancer
Conclusion: Our results suggest the potential role for EIF4A3 to serve as a diagnostic marker or therapeutic target for certain types of cancers. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yan Lin, Jinyan Zhang, Junying Cai, Rong Liang, Guoying Chen, Gang Qin, Xueqiong Han, Chunling Yuan, Zhihui Liu, Yongqiang Li, Donghua Zou, Yingwei Mao Tags: Research Paper Source Type: research

Knockout of MTF1 Inhibits the Epithelial to Mesenchymal Transition in Ovarian Cancer Cells
In this study, we report for the first time that metal regulatory transcription factor 1 (MTF1) was upregulated in ovarian cancer, and its high expression was associated with poor patient survival and disease relapse. Knockout of MTF1 using lentiviral CRISPR/Cas9 nickase vector-mediated gene editing inhibited EMT by upregulating epithelial cell markers E-cadherin and cytokeratin 7, and downregulating mesenchymal markers Snai2 and β-catenin in ovarian cancer SKOV3 and OVCAR3 cells. Loss of MTF1 reduced cell proliferation, migration, and invasion in both SKOV3 and OVCAR3 cells. Knockout of MTF1 upregulated the expressio...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Liang Ji, Guannan Zhao, Peng Zhang, Wenying Huo, Peixin Dong, Hidemichi Watari, Limin Jia, Lawrence M Pfeffer, Junming Yue, Jinhua Zheng Tags: Research Paper Source Type: research

Overexpression of FNDC1 in Gastric Cancer and its Prognostic Significance
Objectives: The aims of this study were to compare the expression of fibronectin type III domain containing 1 (FNDC1) in gastric cancer (GC) and normal gastric tissue, to explore the prognostic significance of FNDC1 expression in patients with gastric adenocarcinoma, and to analyze FNDC1-related signaling pathways.Methods: The expression level of FNDC1 was initially predicted using the Oncomine and Cancer Genome Atlas databases. A Kaplan-Meier plotter database was mined to examine the clinical prognostic significance of FNDC1 mRNA in patients with GC. Subsequently, immunohistochemistry was used to measure FNDC1 protein exp...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jun Ren, Gengming Niu, Xin Wang, Tao Song, Zhiqing Hu, Chongwei Ke Tags: Research Paper Source Type: research

Decoding Somatic Driver Gene Mutations and Affected Signaling Pathways in Human Medulloblastoma Subgroups
The objective of this study is to investigate the involvement of somatic driver gene mutations in these medulloblastoma subgroups. We obtained medulloblastoma data from the Catalogue of Somatic Mutations in Cancer (COSMIC), which contains distinct samples that were not previously studied in a large cohort. We identified somatic driver gene mutations and the signaling pathways affected by these driver genes for medulloblastoma subgroups using bioinformatics tools. We have revealed novel infrequent drivers in these subgroups that contribute to our understanding of tumor heterogeneity in medulloblastoma. Normally SHH signalin...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Charles J. Robbins, Mayassa J. Bou-Dargham, Kevin Sanchez, Matthew C. Rosen, Qing-Xiang Amy Sang Tags: Research Paper Source Type: research

Detection of CK19 mRNA Using One-step Nucleic Acid Amplification (OSNA) in Prostate Cancer: Preliminary Results
Background: Accurate histopathological evaluation of lymph nodes (LNs) is essential for reliable staging in prostate cancer. In routine practice, conventional techniques only examine parts of the LN. Molecular nodal staging methods are limited by their high costs and extensive time requirement. One-step nucleic acid amplification (OSNA) determines the metastatic status of the complete LN and allows for rapid intraoperative detection of LN metastases. OSNA has been proposed for diagnosis of LN metastases from breast cancer by quantifying the CK19 mRNA copy number. To provide basic data for OSNA development for prostate canc...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Alexander Winter, Svenja Engels, Philipp Goos, Marie-Christin S ü ykers, Rolf-Peter Henke, Holger Gerullis, Friedhelm Wawroschek Tags: Research Paper Source Type: research

α -1,2-Mannosidase MAN1C1 Inhibits Proliferation and Invasion of Renal Clear Cell Carcinoma
Conclusion: We find that re-expression of silenced MAN1C1 in ccRCC cell lines inhibited cell viability, colony formation, induced apoptosis, suppressed cell invasion and migration. In conclusion, MAN1C1 is a novel functional tumor suppressor in renal carcinogenesis. This is the first time that the function of MAN1C1 gene has been verified in the renal tumor tissue so far. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Haoming Li, Gang Wang, Yipeng Yu, Wengang Jian, Daming Zhang, Yongquan Wang, Tengda Wang, Yuyang Meng, Chao Yuan, Cheng Zhang Tags: Research Paper Source Type: research

Potential Management of Circulating Tumor DNA as a Biomarker in Triple-Negative Breast Cancer
As a specific subtype of breast cancer, Triple-negative breast cancer (TNBC) is associated with worse prognosis and higher tumor aggressiveness than HER2-amplified or hormone receptor positive breast cancers. Circulating tumor DNA (ctDNA), as a non-invasive “liquid biopsy”, is an emerging original blood-based biomarker for early breast cancer diagnosis, monitoring treatment response, and determining prognosis. In TNBC patients, ctDNA has an inherent tendency to characterize tumor heterogeneity and metastasis-specific mutations providing a key alternative to tumor tissue profiling. Several studies have already d...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Mao Shang, Chunxiao Chang, Yanqing Pei, Yin Guan, Jin Chang, HuiHui Li Tags: Review Source Type: research

Cancer-Associated Fibroblasts Correlate with Tumor-Associated Macrophages Infiltration and Lymphatic Metastasis in Triple Negative Breast Cancer Patients
Conclusion: Cancer-associated fibroblasts were associated with infiltration of CD163-positive macrophages and lymphatic metastasis, and may be potential prognostic predictors of TNBC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jing Zhou, Xiao-Hua Wang, Yi-Xin Zhao, Cheng Chen, Xin-Yun Xu, Qi sun, Hong-Yan Wu, Ming Chen, Jian-Feng Sang, Lei Su, Xiao-Qiao Tang, Xian-Biao Shi, Yin Zhang, Qiao Yu, Yong-Zhong Yao, Wei-Jie Zhang Tags: Research Paper Source Type: research

Hedgehog Interacting Protein 1 is a Prognostic Marker and Suppresses Cell Metastasis in Gastric Cancer
Background: The gene Hedgehog interacting protein (HHIP) is a pivotal morphogen for multiple developmental processes. However, the expression and clinical correlation of HHIP in gastric cancer (GC) has not been fully investigated. Here, we aimed to explore the expression of HHIP in gastric cancer (GC) and evaluate its clinicopathological and functional correlations.Methods: The expression of HHIP mRNA was first determined in the Human Protein Atlas (HPA) and The Cancer Genome Atlas (TCGA) GC database and then validated by RT-qPCR (n = 41) and immunohistochemistry (IHC, n = 95) in a cohort of in-house GC patients and in 29 ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hui Sun, Shu juan Ni, Min Ye, Weiwei Weng, Qiongyan Zhang, Meng Zhang, Cong Tan, Lei Wang, Dan Huang, Xiang Du, Midie Xu, Weiqi Sheng Tags: Research Paper Source Type: research

Proteomic Identification of Plasma Biomarkers in Children and Adolescents with Recurrent Hodgkin Lymphoma
We examined the protein profiles of 15 HL relapsed (R) patients compared with 14 HL not relapsed (NR) patients treated with the same LH-2004 protocol. Two dimensional difference in gel electrophoresis (2D-DIGE) revealed significant differences (fold change> 1.5; Student's T-test p
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ombretta Repetto, Lara Mussolin, Caterina Elia, Lia Martina, Maurizio Bianchi, Salvatore Buffardi, Alessandra Sala, Roberta Burnelli, Maurizio Mascarin, Valli De Re Tags: Research Paper Source Type: research

Fertility Sparing Management in Non-Epithelial Ovarian Cancer. Which Patients, What Procedure and What Outcome?
Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific types of non-epithelial ovarian tumors can be managed with fertility sparing operations with a similar outcome to more radical intervention but due to the rarity of these tumors the extent of the operation remains in some cases controversial. Moreover, the reproductive outcome of the women that had these conser...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Nikolaos Thomakos, Anastasios Malakasis, Nikolaos Machairiotis, Paul Zarogoulidis, Alexandros Rodolakis Tags: Review Source Type: research

Utilization of Reactive Oxygen Species Targeted Therapy to Prolong the Efficacy of BRAF Inhibitors in Melanoma
This study suggests that the combination of A100 with a BRAF inhibitor could be a potential strategy to treat melanoma patients with BRAF mutations. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Long Yuan, Rosalin Mishra, Hima Patel, Safnas Abdulsalam, Kenneth D. Greis, Ana Luisa Kadekaro, Edward J. Merino, Joan T. Garrett Tags: Research Paper Source Type: research

High Expression of lncRNA AFAP1-AS1 Promotes the Progression of Colon Cancer and Predicts Poor Prognosis
Long non-coding RNAs (lncRNAs) are dysregulated in various cancers. However, the clinical relevance and functional roles of AFAP1-AS1 in colon cancer (CC) have not been clarified. We analyzed the lncRNA expression patterns in Gene Expression Omnibus (GEO) datasets and the Cancer Genome Atlas (TCGA) RNA-seq datasets, and found that the expression level of AFAP1-AS1 was significantly elevated in CC tissues. High levels of AFAP1-AS1 were associated with poor disease-free survival and overall survival in CC patients. In vitro experiments demonstrated that AFAP1-AS1 knockdown significantly inhibited the cell invasive and migrat...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hao Bo, Liqing Fan, Jingjing Li, Zhizhong Liu, Shanshan Zhang, Lei Shi, Can Guo, Xiayu Li, Qianjin Liao, Wenling Zhang, Ming Zhou, Bo Xiang, Xiaoling Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng, Fang Xiong, Zhaojian Gong Tags: Research Paper Source Type: research

OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells
Opa interacting protein 5 (OIP5) has previously been identified as a tumorigenesis gene. The purpose of this study is to explore the role of OIP5 in the progression of bladder cancer (BC). The OIP5 expression and clinical behaviors in bladder cancer were collected from lager database. Our study showed that OIP5 was highly expressed in bladder cancer tissues and cells. Overexpression of OIP5 in tumor patients predicted worse overall survival (OS) and higher histological grade. Vitro and vivo experiments demonstrated that knockdown of OIP5 significantly inhibited cell growth of BC. Scratch assay and transwell assay suggested...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Dailian Wang, Zhicong Chen, Fan Lin, Ziqiang Wang, Qunjun Gao, Haibiao Xie, Huizhong Xiao, Yifan Zhou, Fuyou Zhang, Yingfei Ma, Hongbin Mei, Zhiming Cai, Yuchen Liu, Weiren Huang Tags: Research Paper Source Type: research

Revealing Different Lung Metastatic Potentials Induced Metabolic Alterations of Hepatocellular Carcinoma Cells via Proton Nuclear Magnetic Resonance Spectroscopy
Conclusions: Our results provide evidence that NMR-metabolomics analyses of cells are able to understand metastatic characteristics accountable for biological properties. The proposed characteristic metabolites will help to understand HCC metastatic characterizations and may be filtered as potential biomarkers. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yang Chen, Donghong Lin, Zhong Chen, Jianghua Feng, Naishun Liao Tags: Research Paper Source Type: research

Bone Metastases Pattern in Newly Diagnosed Metastatic Bladder Cancer: A Population-Based Study
Conclusion: BM can dramatically decrease the survival of bladder cancer patients. The findings of the present study can provide population-based identification of risk and prognostic factors for BC patients with BM at initial diagnosis, which can be used for BM occurrence prediction and individualized treatment plan-making. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chao Zhang, Lele Liu, Fang Tao, Xu Guo, Guowei Feng, Feiran Chen, Yao Xu, Lili Li, Xiuxin Han, Vladimir P. Baklaushev, Andrey S. Bryukhovetskiy, Xin Wang, Guowen Wang Tags: Research Paper Source Type: research

CLDN10 is Associated with Papillary Thyroid Cancer Progression
The incidence of thyroid cancer is staying at a high level. Claudin family is a skelemin contacting with the intercellular junction and can keep a dynamic balance between cells. Recently, many types of research indicated that the expression level of claudins is closely related to various cancer types and they can be novel diagnostic markers. For instance, Claudin-10(CLDN10) is the high expression in primary hepatocellular carcinoma, papillary thyroid cancer (PTC) and so on. But the biological role and function of CLDN10 in PTC are unclear. In our study, we measured the expression of CLDN10 in human normal tissues and match...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yili Zhou, Jingjing Xiang, Adheesh Bhandari, Yaoyao Guan, Erjie Xia, Xiaofen Zhou, Yinghao Wang, Ouchen Wang Tags: Research Paper Source Type: research

A Randomized Controlled Study of rhTPO and rhIL-11 for the Prophylactic Treatment of Chemotherapy-Induced Thrombocytopenia in Non-Small Cell Lung Cancer
Background: rhTPO and rhIL-11 are both recommended for the prophylactic treatment of chemotherapy-induced thrombocytopenia (CIT). However, there has been no head to head comparative study on the prophylactic administration of rhTPO and rhIL-11 to alleviate CIT in non-small cell lung cancer (NSCLC).Methods: In this open-label prospective multi-center phase II clinical trial, 108 NSCLC patients who experienced severe CIT after prior chemotherapy were randomized into study and control arms. Patients in the study arm were prophylactically administered rhTPO on day 2, day 4, day 6 and day 9 of the subsequent chemotherapy cycle,...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yunhua Xu, Xia Song, Fangmin Du, Qiong Zhao, Li Liu, Zhiyong Ma, Shun Lu Tags: Research Paper Source Type: research

Spontaneous Cancers, But Not Many Induced Ones in Animals, Resemble Semi-New Organisms that Possess a Unique Programmed Cell Death Mode Different from Apoptosis, Senescent Death, Necrosis and Stress-Induced Cell Death
There are four basic cell death modes in animals, i.e. physiological senescent death (SD) and apoptosis as well as pathological necrosis and stress-induced cell death (SICD). There have been numerous publications describing “apoptosis” in cancer, mostly focused on killing cancer cells using radio- or chemo-therapy, with few on exploring how cancer cells die naturally without such treatments. Spontaneous benign or malignant neoplasms are immortal and autonomous, but they still retain some allegiance to their parental tissue or organ and thus are still somewhat controlled by the patient's body. Because of these p...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Mingjun Shi, Haiyan Zhou, Mingjuan Lei, Lichan Chen, Lucas Zellmer, Yan He, Wenxiu Yang, Ningzhi Xu, Dezhong Joshua Liao Tags: Review Source Type: research

Angiopoietin-like Protein 2 is a Useful Biomarker for Pancreatic Cancer that is Associated with Type 2 Diabetes Mellitus and Inflammation
In this study, whether ANGPTL2 can detect early pancreatic cancer was evaluated. It was found that the concentration of serum ANGPTL2 was significantly higher in pancreatic cancer patients and tumor stage 0-I patients than in healthy individuals (5.84 ± 1.82 ng/mL vs 3.61 ± 0.64 ng/mL; P
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Takuma Yoshinaga, Tatsuyuki Niou, Toru Niihara, Yoriko Kajiya, Emiko Hori, Ayako Tomiyoshi, Erena Tokudome, Hiroto Nishimata, Takayuki Takei, Masahiro Yoshida Tags: Research Paper Source Type: research

The Role of Galectins in Tumor Progression, Treatment and Prognosis of Gynecological Cancers
Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell apoptosis, and immune cells, causing tumor invasion, progression, metastasis and angiogenesis. Somehow, galectins are also found to exert a protective effect on cancer in a tissue-dependent way. These glycans binding proteins have been shown to be involved in the regulation of different tumor suppressor ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Mandika Chetry, Saroj Thapa, Xiaoli Hu, Yizuo Song, Jianan Zhang, Haiyan Zhu, Xueqiong Zhu Tags: Review Source Type: research

Body Mass Index is Negatively Associated with Endometrial Cancer Stage, Regardless of Subtype and Menopausal Status
Conclusion: Our data demonstrate that BMI is negatively associated with endometrial cancer in early stage regardless of subtypes of cancer, menopausal status and obesity may be also a potential risk factor for developing type 2 endometrial cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yifei Gao, Xujing Dai, Arier C Lee, Michelle R Wise, Fang Shen, Qi Chen Tags: Research Paper Source Type: research

Functional Genome-wide Screening Identifies Targets and Pathways Sensitizing Pancreatic Cancer Cells to Dasatinib
This study is an unbiased genomic screen to obtain functional targets for increased effectiveness of dasatinib in pancreatic cancer. Dasatinib, a multi-targeted tyrosine kinase inhibitor, is used in clinical trials for treatment of pancreatic cancer; however, intrinsic and acquired resistance often occurs. We used a dasatinib-resistant pancreatic cancer cell line SU8686 to screen for synthetic lethality that synergizes with dasatinib using a pooled human shRNA library followed by next generation sequencing. Novel genes were identified which when silenced produced a prominent inhibitory effect with dasatinib against the pan...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wenwen Chien, Makoto Sudo, Ling-Wen Ding, Qiao-Yang Sun, Peer Wuensche, Kian Leong Lee, Norimichi Hattori, Manoj Garg, Liang Xu, Yun Zheng, Sigal Gery, Sarawut Wongphayak, Henry Yang, Erkan Baloglu, Sharon Shacham, Michael Kauffman, Seiichi Mori, H. Phill Tags: Research Paper Source Type: research

Glucocorticoid-Inducible Kinase 2 Promotes Bladder Cancer Cell Proliferation, Migration and Invasion by Enhancing β -catenin/c-Myc Signaling Pathway
Conclusion: Taken together, our findings suggest SGK2 promotes bladder cancer progression via mediating β-catenin/c-Myc signaling pathway, which may serve as a potential therapeutic target for bladder cancer patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jin-Bo Chen, Meng Zhang, Xiao-Long Zhang, Yu Cui, Pei-Hua Liu, Jiao Hu, Hui-Huang Li, Hang Jin, Long-Fei Liu, Min-Feng Chen, He-Qun Chen, Chao-Zhao Liang, Xiong-Bing Zu Tags: Research Paper Source Type: research

Efficacy and Safety of Everolimus plus Somatostatin Analogues in Patients with Neuroendocrine Tumors
Everolimus, an oral mammalian target of rapamycin(mTOR) inhibitor, which acts upstream of the phosphoinositide 3-kinase/protein kinase B(PI3K/AKT) signaling pathway to downregulate cellular metabolism, growth, proliferation, and angiogenesis, has been shown to significantly prolong the progression-free survival of patients with advanced neuroendocrine tumors. Somatostatin analogues (SSAs) such as octreotide, lanreotide, and pasireotide, have been widely used for symptom control and antiproliferative effects in metastatic or unresectable neuroendocrine tumors. Both everolimus and SSAs have demonstrated antitumor effects in ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wenhao Ge, Dongkai Zhou, Lijun Zhu, Wei Song, Weilin Wang Tags: Research Paper Source Type: research

Aminoacylase 3 Is a New Potential Marker and Therapeutic Target in Hepatocellular Carcinoma
Ras proteins (HRas, KRas and NRas) are common oncogenes that require membrane association for activation. Previous approaches to block/inhibit Ras membrane association were unsuccessful for cancer treatment in human clinical studies. In the present study we utilized a new approach to decrease Ras membrane association in hepatocellular carcinoma (HCC) cell lines via inhibition of an enzyme aminoacylase 3 (AA3; EC 3.5.1.114). AA3 expression was significantly elevated in the livers of HCC patients and HCC cell lines. Treatment of HepG2 cells with AA3 inhibitors, and HepG2 and HuH7 with AA3 siRNA significantly decreased Ras me...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Kirill Tsirulnikov, Sergio Duarte, Anamika Ray, Nakul Datta, Ali Zarrinpar, Lin Hwang, Kym Faull, Alexander Pushkin, Ira Kurtz Tags: Research Paper Source Type: research

Inflammatory Response and Toxicity After Pressurized IntraPeritoneal Aerosol Chemotherapy
Background: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel mode of intraperitoneal (IP) drug delivery claiming high IP tissue concentrations with low systemic uptake. The aim was to study inflammatory response and systemic toxicity after PIPAC.Methods: Retrospective monocentric analysis of a consecutive cohort of PIPAC patients between January 2015 and April 2016. Detailed hematological and biochemical analysis was performed the day before surgery and once daily until discharge. Comparative statistics were performed using Mann-Whitney U test and Wilcoxon signed ranked test.Results: Fourty-two consecuti...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Hugo Teixeira Farinha, Fabian Grass, Isma ï l Labgaa, Basile Pache, Nicolas Demartines, Martin H ü bner Tags: Research Paper Source Type: research

Integrated Analysis of Long Non-Coding RNA and mRNA Expression Profile in Pancreatic Cancer Derived Exosomes Treated Dendritic Cells by Microarray Analysis
Conclusions: To our knowledge, this is the first study to detect the differential expression of lncRNAs and mRNAs associated with PEX-treated DCs. LncRNAs such as ENST00000560647 and mRNAs such as lgmn might play a critical role in immune escape of DCs treated with PEX. Further investigation is required to validate the functions and associations of these RNAs. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jionghuang Chen, Shaowen Wang, Shengnan Jia, Guoping Ding, Guixing Jiang, Liping Cao Tags: Research Paper Source Type: research

Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo
Increasing evidences indicate that shikonin can suppress the tumor growth. However, the mechanisms remain elusive. In the present study, we investigated the effects and mechanisms of shikonin against esophageal cancer. The expression of hypoxia inducible factor 1α (HIF1α) and pyruvate kinase M2 (PKM2) in esophageal cancer tissues and cells was detected by immunohistochemistry and Western blot. CCK-8 was used to examine the esophageal cancer cell viability. Apoptosis and cell cycle were analyzed by flow cytometry. The expression of EGFR, PI3K, Akt, p-AKT, mTOR, HIF1α and PKM2 was detected by Western blot. ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Jian-Cai Tang, Jia Zhao, Feng Long, Jian-ye Chen, Bo Mu, Zhen Jiang, Yonggan Ren, Jian Yang Tags: Research Paper Source Type: research

Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts
Conclusions: mEHT induced caspase-dependent programmed cell death and the release of stress associated DAMP proteins in colorectal cancer allografts can provoke major immune cell infiltration. Accumulating antigen presenting dendritic cells and T-cells are likely to contribute to the ongoing tumor destruction by an immunogenic cell death mechanism both locally and through systemic effect at distant tumor sites. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Tamas Vancsik, Csaba Kovago, Eva Kiss, Edina Papp, Gertrud Forika, Zoltan Benyo, Nora Meggyeshazi, Tibor Krenacs Tags: Research Paper Source Type: research

Pre-treatment Serum Lactate Dehydrogenase is Predictive of Survival in Patients with Nasopharyngeal Carcinoma Undergoing Intensity-Modulated Radiotherapy
Conclusion: High pre-treatment SLDH level predicts poor survival in patients with NPC treated with IMRT-based therapy. As a routinely performed biomarker, pre-treatment SLDH can be utilized in combination with current Tumor-Node-Metastasis staging to predict survival and to plan a personalized treatment in these patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ronald Wihal Oei, Lulu Ye, Fangfang Kong, Chengrun Du, Ruiping Zhai, Tingting Xu, Chunying Shen, Xiaoshen Wang, Xiayun He, Lin Kong, Chaosu Hu, Hongmei Ying Tags: Research Paper Source Type: research

Monocytosis as a prognostic factor for survival in stage IB and IIA cervical cancer
Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer.Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 patients with International Federation of Gynecology and Obstetrics stage IB and IIA cervical cancer who underwent surgical resection. We further assessed the effects of the WBC count and DC-derived hematologic parameters on progression-free survival (PFS) and overall survival (OS) after controlling for other p...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wan Kyu Eo, Byung Su Kwon, Ki Hyung Kim, Heung Yeol Kim, Hong-bae Kim, Suk Bong Koh, Sungwook Chun, Yong Il Ji, Ji Young Lee, Jeong Namkung, Sanghoon Kwon Tags: Research Paper Source Type: research

Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of β -catenin
In this study, we investigated the vital function of MALAT1 in the progression of OS and its potential leading mechanism, altering the expression and localization of β-catenin via epigenetic transcriptional regulation by interacting with EZH2. With the help of MALAT1 silencing using small interfering RNAs (siRNAs), the loss of E-cadherin of MNNG/HOS cells was rescued, and the abnormal expression and localization of β-catenin were corrected at the same time. Overall, our research showed promising potential for new treatment strategies based on epigenetic regulation targeting MALAT1, which will not only coordinate ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Zhi-Chang Zhang, Chun Tang, Yang Dong, Jing Zhang, Ting Yuan, Xiao-Lin Li Tags: Research Paper Source Type: research

Adjuvant Chemotherapy Improves Survival in Stage III Gastric Cancer after D2 Surgery
Conclusions: Our study identified several independent prognostic factors that might help determine the appropriate counseling patients following surgical treatment. D2 surgery alone was inadequate to achieve long-term survival. As the only correctable independent prognostic factor, postoperative adjuvant chemotherapy should be recommended for eligible patients with stage III gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shin-Chun Chang, Keng-Hao Liu, Chia-Yen Hung, Chun-Yi Tsai, Jun-Te Hsu, Ta-Sen Yeh, Jen-Shi Chen, Yung-Chia Kuo, Yu-Shin Hung, Wen-Chi Chou Tags: Research Paper Source Type: research

A comparison of weekly versus 3-weekly cisplatin during concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma using intensity modulated radiation therapy: a matched study
Conclusions: Concurrent cisplatin-based chemotherapy administered weekly or three-weekly in combination with IMRT leads to similar acute toxicities and long-term survival outcomes in locoregionally advanced NPC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Dong-Fang Meng, Rui Sun, Li-Xia Peng, You-Sheng Huang, Qin Yang, Dong-Hua Luo, Wei-Han Hu, Fang-Yun Xie, Wei Luo, Chong Zhao, Ling Guo, Hai-Qiang Mai, Ming-Yuan Chen, Ping Xie, Li-Sheng Zheng, Jun-Ping Yang, Yan Mei, Yuan-Yuan Qiang, Liang Xu, Chang-Zhi L Tags: Research Paper Source Type: research

NcRNAs and Cholangiocarcinoma
Cholangiocarcinoma (CCA) is the most common primary biliary malignancy with poor prognosis. Less understanding of its etiology and pathogenesis makes the diagnosis and therapy difficult. Recently, accumulating evidences have demonstrated that deregulated expression of non-coding RNAs (ncRNAs) is closely associated with the etiopathogenesis of CCA. NcRNAs which lack open reading frame are a heterogeneous class of transcribed RNA molecules, including microRNAs, long non-coding RNAs and circular RNAs. Several studies have shown ncRNAs dysregulation is a common central event occurring in CCA and has the potential of being ther...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Zheng Wangyang, Ji Daolin, Xu yi, Li Zhenglong, Huang Lining, Cui Yunfu, Jiang Xingming Tags: Review Source Type: research

Nuclear EGFR and Integrator/Super Elongation Complex concurrently binds to Immediate Early Genes for gene transactivation
In this study, we integrated gatekeepers of productive transcriptional elongation such as Integrator and Super Elongation Complex (SEC) to interrogate the function of nEGFR. By analyzing publicly available ChIP-seq and RNA-seq data, we aims to 1) explore the function of nEGFR, 2) unravel nEGFR target genes, and 3) discuss potential mechanisms of nEGFR chromatin recruitment. EGF treatment in HeLa cells instigated chromatin recruitment of nEGFR, ERK, RNAPII, Integrator, and SEC in a cluster of 61 EGF-responsive genes. The function of nEGFR was identified as gene-activating rather than gene-repressing. Within the cluster of E...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Victor Chun-Lam Wong Tags: Research Paper Source Type: research

Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma
Conclusion: In summary, in our study dapivirine exposure induces stress, resulting in JNK and PI3K/Akt pathway activation through diminished inhibition of the apoptosis and autophagy cascade in U87 GBM cells, which inhibits cell growth in vitro and in vivo. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Weiwen Liu, Xian-lu Song, Shan-chao Zhao, Minyi He, Hai Wang, Ziyang Chen, Wei Xiang, Guozhong Yi, Songtao Qi, Yawei Liu Tags: Research Paper Source Type: research

Classifying Non-Small Cell Lung Cancer by Status of Programmed Cell Death Ligand 1 and Tumor-Infiltrating Lymphocytes on Tumor Cells
Purpose: To explore the possible correlation between programmed death ligand 1 (PD-L1)/tumor-infiltrating lymphocytes (TIL) status and clinical factors in non-small cell lung (NSCLC).Materials and Methods: A total of 126 surgical NSCLC samples with stage I to IIIA were retrospectively collected and analyzed. Immunohistochemistry (IHC) assays were used to detect PD-L1 protein expression. PD-L1 positivity on tumor cells was defined by positive tumor cell (TC) percentage using 5% cutoff value.Results: Thirty-seven patients (29.4%), thirty patients (23.8%), six patients (4.8%) and fifty-three patients (42%) were classified as ...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Shaohua Cui, Lili Dong, Jialin Qian, Lin Ye, Liyan Jiang Tags: Research Paper Source Type: research

Increased expression of miR-155 and miR-222 is associated with lymph node positive status
Identification of prognostic molecular markers of breast cancer is extremely important. The spreading out of the primary breast tumour cells to the lymphatic system is at the forefront of symbolising the first signs of distant organ metastasis. Deregulated genes in breast cancer tissues that spread to lymph nodes may show early predictive molecular markers. In the present study, we selected five microRNAs, which play a key function in the invasion-metastasis cascade. We investigated the levels of microRNAs in 80 paired samples of BC and matched adjoining tissues, and we examined the potential relationships between microRNA...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Vladimir Chernyy, Vladimir Pustylnyak, Vadim Kozlov, Lyudmila Gulyaeva Tags: Research Paper Source Type: research

Opportunistic salpingectomy at benign gynecological surgery for reducing ovarian cancer risk: a 10-year single centre experience from China and a literature review
In this study, there were 1822 patients diagnosed and treated for EOC or primary peritoneal cancer (PPC) at Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital from January 1, 2007 to April 30, 2017. Among them, 198 patients with a history of gynecological surgery because of benign diseases were enrolled to analyze further. Using 1:2 case-control study, we found that the incidence of EOC was significantly decreased in the population with salpingectomy, compared to women with fallopian tube reserved (P
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Ying Chen, Hui Du, Lewen Bao, Wenxin Liu Tags: Research Paper Source Type: research

Fibrinogen and C-reactive protein score is a prognostic index for patients with hepatocellular carcinoma undergoing curative resection: a prognostic nomogram study
Conclusions: FC-score represents a novel, convenient, reliable, and accurate prognostic predictor for both OS and RFS in HCC patients undergoing curative therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Wei Gan, Yong Yi, Yipeng Fu, Jinlong Huang, Zhufeng Lu, Chuyu Jing, Jia Fan, Jian Zhou, Shuangjian Qiu Tags: Research Paper Source Type: research

KPNA2 promotes migration and invasion in epithelial ovarian cancer cells by inducing epithelial-mesenchymal transition via Akt/GSK-3 β /Snail activation
Conclusions: KPNA2 may reduce the migration and invasion of EOC by inhibiting the Akt/GSK-3β/Snail signaling pathway and suppressing EMT. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Long Huang, Yun Zhou, Xin-Ping Cao, Jia-Xin Lin, Lan Zhang, Shu-Ting Huang, Min Zheng Tags: Research Paper Source Type: research

Hypothesis: Induction of biomarkers for detection of colonic neoplasms
The signing of the National Cancer Act of 1971 by President Nixon marked the beginning of our war on cancer. More than 45 years later, the war is still going steady, with the enemy being almost as strong as in 1971. Furthermore, the increasing rates of obesity not only among adults, but among children and adolescents, are the likely cause for the 30-year trend of colon cancer (CC) becoming a disease of the younger population in the U.S. These trends, however, have not spurred the development of novel screening approaches for CC. Considering the need for a sensitive and non-invasive detection of early stage neoplastic lesio...
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Michael Bordonaro, Darina Lazarova Tags: Hypothesis Source Type: research

Exploration of the optimal treatment regimes for Esthesioneuroblastoma: a single center experience in China
CONCLUSIONS: ENB is a rarely malignant tumor with high probability of locoregional recurrence and poor survival. Surgical resection followed by radiotherapy has been shown to achieve optimal local control and overall survival. (Source: Journal of Cancer)
Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Yujie Yuan, Jinning Ye, Huizhi Qiu, Shaoqing Niu, Bixiu Wen, Dongping Wang, Xinping Cao, Yufeng Ren Tags: Research Paper Source Type: research