Current Ovarian Cancer Maintenance Strategies and Promising New Developments
While ovarian cancer typically responds well to front line treatment, many patients will relapse within 5 years. Treatment options are less effective at each recurrence highlighting the need for novel maintenance therapies. PolyADP-ribose polymerase (PARP) inhibitors have recently gained approval in ovarian cancer maintenance. Niraparib was approved regardless of BRCA mutation status, however impact on overall survival is limited. Oliparib was approved for BRCA mutant and BRCA wildtype/homologous recombination deficient patients. This review will focus on current frontline ovarian cancer treatment as well molecularly based...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Vinaya Gogineni, Susan Morand, Hannah Staats, Rachel Royfman, Monika Devanaboyina, Katelyn Einloth, Danielle Dever, Laura Stanbery, Phylicia Aaron, Luisa Manning, Adam Walter, Gerald Edelman, Lance Dworkin, John Nemunaitis Tags: Review Source Type: research
Tumor-associated macrophages: role in tumorigenesis and immunotherapy implications
This article reviews the interrelationship between TAMs and tumor microenvironment and its related applications in tumor therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Shunyao Zhu, Ziyi Luo, Xixi Li, Xi Han, Senlin Shi, Ting Zhang Tags: Review Source Type: research
Downregulation of CDH11 Promotes Metastasis and Resistance to Paclitaxel in Gastric Cancer Cells
Conclusions: Our results reveal that CDH11 is inhibited in the relapsed PTX-resistant patients and the downregulated CDH11 expression promotes GC cell invasion, migration and PTX resistance. CDH11 may have the potential to serve as a predictable marker for the occurrence of PTX resistance in GC patients with peritoneal metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Zhongyin Yang, Chao Yan, Zhenjia Yu, Changyu He, Jianfang Li, Chen Li, Min Yan, Bingya Liu, Yingli Wu, Zhenggang Zhu Tags: Research Paper Source Type: research
Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt pathway
Conclusions: Shikonin inhibits migration and invasion of TNBC cells by suppressing EMT via miR-17-5p/PTEN/Akt pathway. This suggests shikonin as a promising therapeutic agent to counteract metastasis in the TNBC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Chang Bao, Tao Liu, Lingbo Qian, Chi Xiao, Xinru Zhou, Heng Ai, Jue Wang, Weimin Fan, Jie Pan Tags: Research Paper Source Type: research
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway
Hepatocellular carcinoma (HCC) is a major global health burden and its treatment options are limited. Spermatogenesis associated serine rich 2(SPATS2), a recent defined oncogene, was found to be a prognostic biomarker in HCC. However, the explicit mechanism underlying SPATS2 was urged to be elucidated. In vitro, knockdown of SPATS2 hampered the proliferation, invasion and migration of HCC cells. Moreover, phosphorylation of signal transducer and activator of transcription 3 (STAT3) and its downstream oncogenes were dramatically suppressed by SPATS2 knockdown. In addition, tripartite motif containing 44 (TRIM44) was found t...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Lirong Chen, Chenhe Yi, Wenshuai Li, Yujen Tseng, Jun Zhang, Jie Liu Tags: Research Paper Source Type: research
GINS2 attenuates the development of lung cancer by inhibiting the STAT signaling pathway
GINS complex subunit 2 (GINS2) controls DNA replication. GINS2 expression is upregulated in several kinds of aggressive tumors. However, the effect of GINS2 in lung cancer remains unclear. We performed TCGA database analysis to confirm the clinical significance of GINS2 in lung cancer. After silencing GINS2 in A549 cells, we performed MTT assays, flow cytometry assays, colony formation assays, cell cycle analyses and RNA sequence analysis to elucidate the effect of GINS2 on lung cancer. Moreover, we assessed tumor growth and analyzed body fluorescence in mice as a measure of tumor burden. The TCGA database analysis demonst...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Dianmin Sun, Yuanyuan Zong, Jinling Cheng, Zhenxiang Li, Ligang Xing, Jinming Yu Tags: Research Paper Source Type: research
Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study
Population-based studies investigating the association between dietary mineral intake and risk of cervical intraepithelial neoplasia (CIN) or cervical cancer in Chinese women are few. We performed a cross-sectional analysis of screening data obtained from 2,304 women in 2014 within an ongoing cohort study comprising 40,000 women in China. Dietary intake was assessed using a semiquantitative food frequency questionnaire. Nutrition intake was calculated using a 26-item list of food sources drawn from a validated, comprehensive database. All participants were surveyed through in-person interviews, physical examinations, and l...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Zhe Wang, Wenhao Wang, Aimin Yang, Weihong Zhao, Jing Yang, Zhilian Wang, Wei Wang, Xiaoqiang Su, Jintao Wang, Jinghui Song, Li Li, Weiguo Lv, Dongyan Li, Huiqiang Liu, Chen Wang, Min Hao Tags: Research Paper Source Type: research
Screening Study on the Anti-Angiogenic Effects of Traditional Chinese Medicine - Part II: Wild Chrysanthemum
Conclusion: Wild chrysanthemum has a significant anti-angiogenic effect in zebrafish and it may have an inhibitory action on the regulatory particle of the proteasome. The mechanisms underlying the anti-angiogenic effects of wild chrysanthemum may be related to the down-regulation of proteasome/β-catenin signaling in zebrafish. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xiang Tu, He Bin Wang, Qun Huang, Yi Cai, Yuan Ping Deng, Zhe Yong, Quan Hu, Jian Feng, James B. Jordan, Sen Zhong Tags: Research Paper Source Type: research
U three protein 14a (UTP14A) promotes tumour proliferation and metastasis via the PERK/eIF2a/GRP78 signalling pathway in oesophageal squamous cell carcinoma
In conclusion, UTP14A might promote the proliferation and metastasis of ESCC cells by inducing PERK/eIF2a signalling pathway expression. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Kun-Kun Li, Cheng-Yi Mao, Qiang Ma, Tao Bao, Ying-Jian Wang, Wei Guo, Xiao-Long Zhao Tags: Research Paper Source Type: research
Increased Reactive Oxygen Species and Distinct Oxidative Damage in Resveratrol-suppressed Glioblastoma Cells
Conclusions: Resveratrol increased ROS generation and induced oxidation-related cellular lesions in U251 cells by activating an ROS-related mitochondrial signal pathway. The levels of SULTs and ROS may indicate the therapeutic outcomes of resveratrol treatment in GBM. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Bin Jia, Xu Zheng, Mo-Li Wu, Xiao-Ting Tian, Xue Song, Yan-Na Liu, Pei-Nan Li, Jia Liu Tags: Research Paper Source Type: research
ALKAL1 gene silencing prevents colorectal cancer progression via suppressing Sonic Hedgehog (SHH) signaling pathway
Anaplastic lymphoma kinase (ALK) has been described in a range of human cancers and is involved in cancer initiation and progression via activating multiple signaling pathways, such as the PI3K-AKT, CRKL-C3G, MEKK2/3-MEK5-ERK5, JAK-STAT and MAPK signal pathways. Recently ALK and LTK ligand 1 (ALKAL1) also named “augmentor-β” or “FAM150A” is identified as a potent activating ligands for human ALK that bind to the extracellular domain of ALK. However, due to its poor stability, the mechanisms of ALKAL1 underlying the tumor progression in the human cancers including colorectal cancer have not been...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Shasha Chen, Bin Wang, Xuekun Fu, Yanfang Liang, Xingxing Chai, Ziyu Ye, Ronggang Li, Yaoming He, Gang Kong, Jiachun Lian, Xiangyong Li, Ting Chen, Xin Zhang, Xianxiu Qiu, Xudong Tang, Keyuan Zhou, Bihua Lin, Jincheng Zeng Tags: Research Paper Source Type: research
Gemcitabine, oxaliplatin and dexamethasone (GemDOx) as salvage therapy for relapsed or refractory diffuse large B-cell lymphoma and peripheral T-cell lymphoma
Conclusion: With acceptable efficacy and good tolerability, GemDOx might be a new therapeutic option for relapsed or refractory DLBCL and PTCL. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Qiu-Dan Shen, Li Wang, Hua-Yuan Zhu, Jin-Hua Liang, Yi Xia, Jia-Zhu Wu, Lei Fan, Jian-Yong Li, Wei Xu Tags: Research Paper Source Type: research
Distinct Impacts of Pre-Operative Antiviral Treatment on Post-Operative Outcomes of HBV-related Hepatocellular Carcinoma: A Landmark Analysis
Conclusions: Pre-operative AVT could significantly improve the RFS, and could not improve short-term OS (< 36 months) but could better long-term survival of the patients with HBV-HCC after surgery. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Jun Fu, Zongren Ding, Qinjunjie Chen, Kongying Lin, Hongzhi Liu, Yuzhen Gao, Yongyi Zeng, Haitao Li, Feng Shen, Jingfeng Liu Tags: Research Paper Source Type: research
Loss of LIMCH1 predicts poor prognosis in patients with surgically resected Lung Adenocarcinoma: A study based on Immunohistochemical Analysis and Bioinformatics
Conclusions: Our findings suggest that LIMCH1 may serve as a promising biomarker to predict LUAD prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: He Cao, Jing Zhao, Zhen Chen, Wenjia Sun, Kexin Ruan, Jianya Zhou, Jianying Zhou Tags: Research Paper Source Type: research
A Noninvasive Assessment of Tumor Proliferation in Lung cancer Patients using Intravoxel Incoherent Motion Magnetic Resonance Imaging
In conclusion, D values were negatively correlated with Ki-67 expression in lung cancer tissues and can be used to distinguish high from low proliferation statuses, as well as SCLC from NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Yu Zheng, Wenjun Huang, Xuelin Zhang, Chen Lu, Caixia Fu, Shihong Li, Guangwu Lin Tags: Research Paper Source Type: research
