Efficacy of CapeOX plus Cetuximab Treatment as a First-Line Therapy for Patients with Extended RAS/BRAF/PIK3CA Wild-Type Advanced or Metastatic Colorectal Cancer
Conclusions: Patients with RAS/BRAF/PIK3CA wild-type mCRC had a sufficient RR following first-line treatment with CapeOX + cetuximab. These results suggest that this combination therapy should be considered as a treatment option for patients with advanced mCRC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shigeyoshi Iwamoto, Hiromichi Maeda, Shoichi Hazama, Koji Oba, Naoko Okayama, Yutaka Suehiro, Takahiro Yamasaki, Nobuaki Suzuki, Hiroaki Nagano, Junichi Sakamoto, Hideyuki Mishima, Naoki Nagata Tags: Research Paper Source Type: research

Immunoscore System for Predicting Clinical Outcome of Metastatic Renal Cell Carcinoma Patients Treated with Tyrosine Kinase Inhibitors
We conducted this study to determine whether immunoscore system (IS) predicts survival in patients with metastatic renal cell carcinoma (mRCC). A total of 218 mRCC patients treated with sunitinib or sorafenib in Zhongshan Hospital, Fudan University were recruited during 2007-2017, retrospectively. CD8, CD4, Treg, PD-1 and PD-L1 expression were evaluated by immunohistochemical staining of paraffin embedded slide. Kaplan-Meier method and COX regression model were used in survival analyses. Multivariate analyses demonstrated that expressions of CD8, Treg, PD-1 and stromal PD-L1 (sPD-L1) expressions were independent predictive...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jia-Xi Yao, Xiang Chen, Wei Xi, Yan-Jun Zhu, Hang Wang, Xiao-Yi Hu, Jian-Ming Guo Tags: Research Paper Source Type: research

Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico
Conclusion: Our study provides a comprehensive understanding of BAP1 functional somatic mutation in ccRCC patients. Several hub genes like CAD and TSPO may become potential therapeutic targets. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shengming Jin, Junlong Wu, Yao Zhu, Weijie Gu, Fangning Wan, Wenjun Xiao, Bo Dai, Hailiang Zhang, Guohai Shi, Yijun Shen, Yiping Zhu, Dingwei Ye Tags: Research Paper Source Type: research

Nomogram to Predict Cancer-Specific Survival in Patients with Pancreatic Acinar Cell Carcinoma: A Competing Risk Analysis
Conclusion: We evaluated the 1-, 2- and 3-year OS and CSS in patients with ACC for the first time. Our nomograms showed relatively good performance and could be considered as convenient individualized predictive tools for prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chaobin He, Yu Zhang, Zhiyuan Cai, Fangting Duan, Xiaojun Lin, Shengping Li Tags: Research Paper Source Type: research

Identification of Integrin β 1 as a Novel PAG1-Interacting Protein Involved in the Inherent Radioresistance of Human Laryngeal Carcinoma
Inherent radioresistance plays a crucial role in the failure of radiotherapy. Using the inherent radioresistant (Hep-2max) and radiosensitive (Hep-2min) cell lines established from the parental cell line Hep-2, we previously reported that phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) overexpression in laryngeal carcinoma cells was correlated with inherent radioresistant phenotypes. However, the underlying mechanisms of this effect remain unknown. In the present study, we performed a proteomic screen to investigate the interactome of PAG1 in Hep-2max cells resulting in the identification of ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiaoxia Dong, Zhiguo Luo, Tiantian Liu, Jingjing Chai, Qing Ke, Li Shen Tags: Research Paper Source Type: research

LINC00852 Promotes Lung Adenocarcinoma Spinal Metastasis by Targeting S100A9
Conclusion: LINC00852 targets S100A9 to promote progression and oncogenic ability in lung adenocarcinoma SM through activation of the MAPK pathway. These findings suggest a potential novel target for early intervention against SM in lung cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Peng Liu, Houlei Wang, Yun Liang, Annan Hu, Rong Xing, Libo Jiang, Lei Yi, Jian Dong Tags: Research Paper Source Type: research

Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway
Conclusion: Niclosamide has effective function in anti-HCC and may be a single or combined drug treatment for HCC and acts via the STAT3 signaling pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chengzhi Wang, Xiaoqing Zhou, Hongjuan Xu, Xiaqing Shi, Jinfeng Zhao, Manyi Yang, Lihua Zhang, Xin Jin, Yu Hu, Xia Li, Xiangcheng Xiao, Mingmei Liao Tags: Research Paper Source Type: research

Role of lncRNA and EZH2 Interaction/Regulatory Network in Lung Cancer
Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts and longer than 200 nucleotides. LncRNAs have been demonstrated to modulate gene expression at transcriptional, post-transcriptional, as well as epigenetic levels in lung cancer. Interestingly, compelling studies have revealed that lncRNAs participated in the EZH2 oncogenic regulatory network. EZH2 plays an important role in the initiation, progression and metastasis of cancer. On one hand, lncRNAs can directly bind to EZH2, recruit EZH2 to the promoter region of genes and repress their exp...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Min Su, Yuhang Xiao, Jinming Tang, Jie Wu, Junliang Ma, Bo Tian, Yong Zhou, Hui Wang, Desong Yang, Qian-jin Liao, Wenxiang Wang Tags: Review Source Type: research

CASP8 rs3834129 (-652 6N insertion/deletion) Polymorphism and Colorectal Cancer Susceptibility: An Updated Meta-Analysis
CASP8 rs3834129 polymorphism (-652 6N insertion/deletion) is a genetic alteration which might affect the apoptosis pathway caspase enzyme. The impaired caspase enzyme would lead to the change of cancer risk. By now, the role of CASP8 rs3834129 polymorphism has been widely investigated. However, the relationship of this genetic variant on colorectal cancer (CRC) susceptibility still remains inconsistent. Therefore, we further investigated the role of rs3834129 polymorphism on CRC risk. Eligible published studies were retrieved from EMBASE, PubMed, CNKI and WANFANG database updates to March 2018. Odds ratios (ORs) and 95% co...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yin Ying, Jin Xu, YaJun Qi, Meiling Zhang, Yue Yang Tags: Research Paper Source Type: research

Prognostic Influence of the Time Interval between Surgery and Chemotherapy in Epithelial Ovarian Cancer
In conclusion, delayed TTC was associated with higher rates of EOC recurrence and survival among these patients with advanced stage. The findings of the present study may provide evidence for gynecologist as well as these ovarian cancer patients to make further decision for the treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiao-Dong Liu, Yi Liu, Ting-Ting Gong, Jing-Yi Guo, Ya-Nan Wang, Ling Wang, Qi-Jun Wu, Yi-Sheng Jiao Tags: Research Paper Source Type: research

Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis
Conclusions: Down-regulated miRNA-34a expression is a prognostic marker for poor osteosarcoma. We should be more committed to investigate the clinical significance of miRNA-34a in osteosarcoma patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wenyi Wang, Shaopu Hu, Junli Chang, Hongfeng Ruan, Wenlan Zhi, Xiaobo Wang, Qi Shi, Yongjun Wang, Yanping Yang Tags: Research Paper Source Type: research

MicroRNA-376c-3p Facilitates Human Hepatocellular Carcinoma Progression via Repressing AT-Rich Interaction Domain 2
Hepatocellular carcinoma (HCC), accounting for approximately 90% of liver cancer, is the most lethal malignant tumors in the world. Large amount of evidence indicate that microRNAs (miRNAs) contribute to the tumorigenesis and progression of HCC. Among them, miR-376c-3p was recently identified as a tumor-related miRNA and is up-regulated in HBV-related HCC. But, the clinical significance of miR-376c-3p and its biological function in HCC progression are still unclear. Here, we confirmed that miR-376c-3p expression level in HCC was markedly higher than that in noncancerous tissues. Up-regulation of miR-376c-3p was detected in...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yuan Wang, Weiping Chang, Wanli Chang, Xiaowei Chang, Song Zhai, Guoying Pan, Shuangsuo Dang Tags: Research Paper Source Type: research

Management Of Synchronous Krukenberg Tumors From Gastric Cancer: a Single-center Experience
In this study, we examined the survival benefit of metastasectomy combined with chemotherapy for treatment of synchronous Krukenberg tumors from gastric cancer and identified the prognostic factors.Methods: The subjects of this study were patients diagnosed as synchronous Krukenberg tumors of gastric origin in the period between December 2004 and December 2015. Patients were classified in accordance with treatment modality: metastasectomy group (metastasectomy combined with chemotherapy) and non-metastasectomy group (chemotherapy alone). Clinicopathological characteristics together with treatment records were investigated ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Dingding Yan, Yian Du, Gaiguo Dai, Ling Huang, Qi Xu, Pengfei Yu Tags: Research Paper Source Type: research

Clinical Effect of Adjuvant Cytokine-Induced Killer Cells Immunotherapy in Patients with Stage II-IVB Nasopharyngeal Carcinoma after Chemoradiotherapy: A propensity score analysis
As an adjuvant immunotherapy, cytokine-induced killer cells (CIKs) infusion has been demonstrated to exert potent effectiveness in several types of cancer patients who received curative treatment. However, controversy exists regarding whether nasopharyngeal carcinoma (NPC) patients can benefit from additional treatment after radical radiotherapy or chemoradiotherapy to improve their distant control and survival. In this retrospective study, we aimed to evaluate the efficacy of adjuvant CIK cells therapy in NPC patients with stage II-IVB after curative treatment. From January 1, 2005 to December 31, 2012, 85 pairs of NPC pa...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jing-Jing Zhao, Shu Zhou, Chang-Long Chen, Hong-Xia Zhang, Zi-Qi Zhou, Zheng-Rong Wu, Yuan Liu, Qiu-Zhong Pan, Qian Zhu, Yan Tang, Jian-Chuan Xia, De-Sheng Weng Tags: Research Paper Source Type: research

CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation
Approximately 90% of patients diagnosed with non-small cell lung cancer (NSCLC) die due to distant metastases. However, the complicated molecular and cellular mechanisms involved in lung cancer metastasis remain poorly understood. Copine III (CPNE3), a member of a Ca2+-dependent phospholipid-binding protein family, was identified as a novel metastasis-associated protein in NSCLC in our previous study, however, its function in metastasis remains unclear. Here, we found that CPNE3 was expressed at high levels in NSCLC tissues and advanced TNM stages and was significantly associated with poor prognosis. In addition, CPNE3 int...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hechun Lin, Xiao Zhang, Li Liao, Tao Yu, Jing Li, Hongyu Pan, Lei Liu, Hanwei Kong, Lei Sun, Mingxia Yan, Ming Yao Tags: Research Paper Source Type: research

A Nomogram Predicting Extrahepatic Metastases for Patients with Adjuvant Transarterial Chemoembolization after Hepatectomy
Conclusions: This novel nomogram can identify those with high risk of EHMs after adjuvant TACE following hepatectomy. The validation cohort showed a good performance, suggesting it could benefit surgeons on decision-making. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shipeng Chen, Yuzhen Gao, Zheng Li, Jian'an Jia, Meng Fang, Mengmeng Wang, Huijuan Feng, Qinjunjie Chen, Wenqian Guan, Ziyi Wang, Chunfang Gao Tags: Research Paper Source Type: research

P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study
Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p.Arg72Pro) and a higher disease risk in the presence of HPV is documented. The p53 p.Arg72 variant was described as a risk factor for developing a malignancy in combination with the presence of HPV as the p.72Arg variant is more prone to HPV E6 protein-mediated degradation than the p.72Pro variant. For penile carcinoma there are only sp...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Robert Stoehr, Rebecca Weisser, Olaf Wendler, Johannes Giedl, Khalid Daifalla, Nadine T. Gaisa, Georg Richter, Valentina Campean, Maximilian Burger, Bernd Wullich, Arndt Hartmann Tags: Research Paper Source Type: research

Long Non-coding RNA LINC01234 Regulates Proliferation, Invasion and Apoptosis in Esophageal Cancer Cells
The objective of the study was to investigate the expression and role of LINC01234 in progression of esophageal cancer cells. LncRNA LINC01234 was found to be upregulated in esophageal cancer cells by chip sequencing. The expression level of LINC01234 was detected from different esophageal cancer cell lines by qRT-PCR. After this, the LINC01234 knockdown effects on cell proliferation, migration, invasion, and apoptosis were evaluated by cell proliferation assay, wound healing assay, invasion assay, and flow cytometric analysis in vitro. Expression of lncRNA LINC01234 was found to be markedly upregulated in the CEC2 cell li...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, Yangjunqi Wang, Changshuo Li, Su Chen, Yi Zeng Tags: Research Paper Source Type: research

Predictors of Residual T1 High Grade on Re-Transurethral Resection in a Large Multi-Institutional Cohort of Patients with Primary T1 High-Grade/Grade 3 Bladder Cancer
The aim of this multi-institutional study was to identify predictors of residual high-grade (HG) disease at re-transurethral resection (reTUR) in a large cohort of primary T1 HG/Grade 3 (G3) bladder cancer patients.A total of 1155 patients with primary T1 HG/G3 bladder cancer from 13 academic institutions that underwent a reTUR within 6 weeks after first TUR were evaluated. Logistic regression analysis was performed to assess the association of predictive factors with residual HG at reTUR.Residual HG cancer was found in 288 (24.9%) of patients at reTUR. Patients presenting residual HG cancer were more likely to have carcin...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Matteo Ferro, Giuseppe Di Lorenzo, Carlo Buonerba, Giuseppe Lucarelli, Giorgio Ivan Russo, Francesco Cantiello, Abdal Rahman Abu Farhan, Savino Di Stasi, Gennaro Musi, Rodolfo Hurle, Serretta Vincenzo, Gian Maria Busetto, Ettore De Berardinis, Sisto Perdo Tags: Research Paper Source Type: research

The Association of Baseline Serum Tumour Markers with Outcome of Patients with Metastatic Colorectal Cancer Treated with Anti-EGFR Monoclonal Antibodies in the First Line
The measurement of serum tumour markers is a simple and non-invasive method for assessing the response to systemic therapies in metastatic colorectal cancer (mCRC) and estimation of prognosis. The aim of our retrospective study was to evaluate the association of baseline serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), thymidine kinase (TK) and tissue polypeptide specific antigen (TPS) with outcome of patients with mCRC treated with combination of chemotherapy and monoclonal antibodies against epidermal growth factor receptor (anti-EGFR mAbs) in the first line. In our study, the cohort i...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ondrej Fiala, Petr Hosek, Ondrej Sorejs, Vaclav Liska, Tomas Buchler, Alexandr Poprach, Radek Kucera, Ondrej Topolcan, Monika Sedivcova, Jindrich Finek Tags: Research Paper Source Type: research

Distinct Changes in the Expression TAZ are Associated with Normal Cervix and Human Cervical Cancer
In this study, we examined the TAZ protein expression and cellular localization in 194 cases of human cervical squamous cell carcinoma (SCC). We observed that a normal cervix is characterized by higher expression levels of both nuclear and cytosolic TAZ compared to cervical SCC. Lower membranous and cytosolic TAZ expression levels are associated with lymph node involvement. We observed that TAZ expression levels are associated with β1 integrin and Src in SCC and cell lines derived from human cervical cancers. Of note, knock down of TAZ increased the expression of β1 integrin and Src in both normal and human cervi...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yaofang Liu, Meiping Ren, Xiaoyong Tan, Lina Hu Tags: Research Paper Source Type: research

Interplay of Tumor Spread, Volume and Epstein-Barr Virus DNA in Nasopharyngeal Carcinoma: Feasibility of An Integrative Risk Stratification Scheme
Conclusions: Both anatomic spread and tumor volume contribute to pEBV DNA level, leading to strong inter-correlation between NPC stage, volume and EBV DNA. The proposed risk stratification combining anatomic, volumetric and biological features showed potential in refining DMFS prediction. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xin Zhou, Youqi Yang, Xiaomin Ou, Tingting Xu, Chunying Shen, Chaosu Hu Tags: Research Paper Source Type: research

Prognostic Impact of TTF-1 Expression in Non-Squamous Non-Small-Cell Lung Cancer: A Meta-Analysis
Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to gain a better insight into the prognostic role of TTF-1 in patients only with non-squamous (non-SQ) NSCLC. A systematic computerized search of the electronic databases including PubMed, PMC, EMBASE, Web of Science, and Cochrane Library was performed. From 21 studies, 6,451 patients were included in the combined ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jung Han Kim, Hyeong Su Kim, Bum Jun Kim, Boram Han, Dae Ro Choi, Jung Hye Kwon Tags: Research Paper Source Type: research

Prognostic Value of Lymphocyte Activation Gene-3 (LAG-3) Expression in Esophageal Squamous Cell Carcinoma
This study is aim to examine the expression and the prognostic value of LAG-3 in ESCC. We applied immunohistochemistry analysis to examine the expression of LAG-3, CD4 and CD8 in 287 ESCC cohorts. Our study demonstrated that the decreased LAG-3 expression was significantly associated with CD4 tumor-infiltrated lymphocytes (TILs) (p=0.000), CD8 TILs (p=0.000), and the advanced clinical stages (p=0.041) by Chi-square analysis. Kaplan-Meier survival analysis revealed that higher LAG-3 expression were positively correlated with a better overall survival (OS) (p=0.010) and better progression free survival (PFS) (p=0.006), espec...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yu Zhang, Yong-dong Liu, Yi-ling Luo, Bin-liu Liu, Qi-tao Huang, Fang Wang, Qian Zhong Tags: Research Paper Source Type: research

FABP1 Polymorphisms Contribute to Hepatocellular Carcinoma Susceptibility in Chinese Population with Liver Cirrhosis: A Case-Control Study
Purpose: Single nucleotide variations in the liver fatty acid binding protein (L-FABP, FABP1) gene lead to changes in cellular signaling pathways and lipid metabolism. FABP1 polymorphisms were associated with some liver diseases, like steatotic hepatocellular carcinoma. However, the association between FABP1 rs1545224 and rs2241883 polymorphisms and hepatitis B virus-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC) has not been reported. We performed this study to explore their relationship.Methods: One thousand individuals (250 healthy controls, 250 chronic HBV (CHB), 250 LC, and 250 HCC patients) were recr...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Meng Wang, Xinghan Liu, Shuai Lin, Tian Tian, Feng Guan, Yan Guo, Xiao Li, Yujiao Deng, Yi Zheng, Peng Xu, Qian Hao, Zhen Zhai, Zhijun Dai Tags: Research Paper Source Type: research

Effect of Liposomal Doxorubicin in Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC)
Conclusion: Our data indicate that liposomal coating of doxorubicin and possibly other chemotherapeutical drugs might inhibit their interaction with the peritoneal surface. This inhibition appears to be relatively strong, since doxorubicin is partially undetectable due to liposomal coating. Further studies are warranted to investigate this interaction and its potential benefit in peritoneal applications. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Agata Mikolajczyk, Veria Khosrawipour, Justyna Schubert, Jakub Grzesiak, Haris Chaudhry, Alessio Pigazzi, Tanja Khosrawipour Tags: Research Paper Source Type: research

Incidence and Survival Outcomes of Breast Cancer with Synchronous Hepatic Metastases: A Population-Based Study
Background: Little is known about the clinical features of breast cancer with synchronous hepatic metastases (BCSHM). In this retrospective study, we aimed to feature the incidence and survival outcome of BCSHM.Methods: Data from the 2016 SEER*Stat database (version 8.3.2) was used. The effect of patient and tumor characteristics on the odds of developing of BCSHM was analyzed. Survival was investigated using Kaplan-Meier and Cox regression analyses. A competing risk model was also applied to further investigate cancer-specific survival.Results: Of 240911 patients with breast cancer, we identified 3468 patients (1.44%) wit...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Weikai Xiao, Shaoquan Zheng, Anli Yang, Xingcai Zhang, Peng Liu, Xinhua Xie, Hailin Tang, Xiaoming Xie Tags: Research Paper Source Type: research

Autophagy Plays a Critical Role in Insulin Resistance- Mediated Chemoresistance in Hepatocellular Carcinoma Cells by Regulating the ER Stress
In conclusion, autophagy facilitates the HCC survival in chemotherapeutic drug treatment by maintaining the homeostasis in the ER indicating the regulatory role of autophagy in ER stress contributes to IR-mediated chemoresistance in hepatocellular carcinoma cells. Collectively, these data implied inhibition of autophagy is a potential treatment of inherent IR-mediated chemoresistance in HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Linjing Li, Xinyue Liu, Liye Zhou, Wei Wang, Zhuan Liu, Yan Cheng, Jing Li, Hulai Wei Tags: Research Paper Source Type: research

The Clinical and Biomarker Association of Programmed Death Ligand 1 and its Spatial Heterogeneous Expression in Colorectal Cancer
This study was aimed to explore the clinical and biomarker association of programmed death ligand 1 and its spatial heterogeneous expression in colorectal cancer.Methods: Tissue microarrays of 422 primary colorectal cancers from our hospital were used for the interpretation of PD-L1 and programmed death 1 (PD-1) expression, cluster of differentiation 4 (CD4) and CD8 density and microsatellite instability (MSI) status by immunohistochemistry. To assess the spatial heterogeneity of PD-L1 expression, Tissue microarrays of 383 paired intra-primary-tumor tissues, and 105 paired lymph node metastatic tumors and 64 paired distant...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiao-Li Wei, Qi-Nian Wu, Dong-liang Chen, Zhao-Lei Zeng, Jia-Bin Lu, Ze-Xian Liu, Huai-Qiang Ju, Chao Ren, Zhi-Zhong Pan, Feng-Hua Wang, Rui-Hua Xu Tags: Research Paper Source Type: research

ABO Blood Type Has No Impact on Survival in Patients with Epithelial Ovarian Cancer
This study applied a retrospective cohort and included 627 EOC patients diagnosed at Shengjing Hospital of China Medical University between 2011 and 2015. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) between the ABO blood type and progression-free survival (PFS) and overall survival (OS) of EOC patients were assessed using multivariable Cox proportional regression models. The median follow-up duration was 2.97 years (inter-quartile range from 2.11 to 4.13 years). The recurrence and mortality rates were 41.5% (260/627) and 37.0% (232/627), respectively. Possessing a comorbidity, residual disease, ascites,...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ling Wang, Zhuo Yang, Yi Liu, Ya-Nan Wang, Jing-Yi Guo, Qi-Jun Wu, Ting-Ting Gong Tags: Research Paper Source Type: research

Detection of Exon 12 and 14 Mutations in Janus Kinase 2 Gene Including a Novel Mutant in V617F Negative Polycythemia Vera Patients from Pakistan
The most frequently reported genetic aberration among polycythemia vera (PV) patients is a gain of function mutation V617F in exon 14 of Janus kinase 2 (JAK2) gene. However in many investigations, V617F negative PV patients have been reported to harbor mutations in JAK 2 exon 12. We investigated 24 patients with PV (diagnosed following 2016 WHO guidelines) to detect V617F mutation through allele specific PCR. The frequency of which was found to be 19/24 (79.2 %). Later on JAK2 exon 12 and 14 was amplified by conventional PCR in V617F negative patients and subjected to sequence analysis. A total of 03 mutated sites in exon ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Afia Muhammad Akram, Humera kausar, Asma Chaudhary, Ahmad Mukhtar Khalid, Muhammad Mudassar Shahzad, Muhammad Waheed Akhtar, Muhammad Farooq Sabar, Nadia Sajid, Nawaf Al Anazi, Aamir Aleem, Zafar Iqbal Tags: Research Paper Source Type: research

Prognostic Value of the Cycle Number of Perioperative Chemotherapy in Locoregionally Advanced Rectal Cancer: a Propensity Score Matching Analysis
This study aimed to evaluate how cycle number of perioperative chemotherapy influenced the prognosis of LARC patients.Methodology / Principal Findings: In this study, a total of 388 consecutive patients were enrolled and retrospectively reviewed if they were diagnosed with untreated stage cII-III LARC and treated with neoadjuvant chemoradiotherapy plus radical surgery followed by adjuvant chemotherapy or not. After grouping by the postoperative pathologic stage (yp0-I vs. ypII-III), propensity score matching was performed in each group to balance baseline characteristics between the patients treated with chemotherapy cycle...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hui Chang, Xin Yu, Kai Chen, Qiao-xuan Wang, Shu Zhang, Zhi-fan Zeng, Pei-rong Ding, Zhi-zhong Pan, Wei-wei Xiao, Yuan-hong Gao Tags: Research Paper Source Type: research

Prognostic Values of LAPTM4B-35 in Human Cancer: A Meta-analysis
Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers.Methods: The relevant publications were obtained by systematically searching the PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for the prognosis value of LAPTM4B-35 for cancer patient....
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Linghui Zhou, Cong Dai, Tian Tian, Meng Wang, Shuai Lin, Yujiao Deng, Peng Xu, Qian Hao, Ying Wu, Tielin Yang, Wenge Zhu, Zhijun Dai Tags: Research Paper Source Type: research

Promotion of Cell Proliferation through Inhibition of Cell Autophagy Signalling Pathway by Rab3IP is Restrained by MicroRNA-532-3p in Gastric Cancer
Conclusions: Our study elucidates the central role of Rab3IP in inducing proliferation of GC cells through its involvement in autophagy. miR-532-3p directly targets Rab3IP and represses its function, thereby demonstrating a novel regulatory link in GC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Weihong Guo, Zhaoyu Chen, Zhian Chen, Jiang Yu, Hao Liu, Tuanjie Li, Tian Lin, Hao Chen, Mingli Zhao, Guoxin Li, Yanfeng Hu Tags: Research Paper Source Type: research

PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine
Conclusions: Anchored-GM-CSF vaccines and anti-PD-1 antibodies have synergistic effects in metastatic bladder cancer treatment. PD-1 blockade can overcome immune resistance in treatment with the Anchored-GM-CSF vaccine, while Anchored-GM-CSF vaccine can enhance the efficacy of PD-1 blockade therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xinji Zhang, Xiaojun Shi, Jinlong Li, Lijun Mo, Zhiming Hu, Jimin Gao, Shihao Wu, Zhaolin Long Tags: Research Paper Source Type: research

A Nomogram Based on a TRUS Five-Grade Scoring System for the Prediction of Prostate Cancer and High Grade Prostate Cancer at Initial TRUS-Guided Biopsy
Purpose: To evaluate the efficacy of transrectal ultrasound five-grade scoring system (TRUS-5) in predicting prostate cancer (PCa) and high grade PCa (HGPCa), compared with TRUS two-grade scoring system (TRUS-2), and establish a TRUS-5 based nomogram for the prediction of PCa and HGPCa at initial biopsy (IPBx).Methods: Data were collected from 862 men who underwent initial TRUS-guided 12-core prostate biopsy. Age, prostate-specific antigen (PSA), percent free PSA, digital rectal examination (DRE), prostate volume (PV), PSA density (PSAD) and TRUS findings were included in the analysis. For TRUS-5, the probability of PCa wa...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shao Wei Xie, Yan Qing Wang, Bai Jun Dong, Jian Guo Xia, Hong Li Li, Shi Jun Zhang, Feng Hua Li, Wei Xue Tags: Research Paper Source Type: research

Oncolytic Adenovirus Harboring Interleukin-24 Improves Chemotherapy for Advanced Prostate Cancer
Conclusion: We reported the synergistic anti-tumor efficacy of ZD55-IL-24 and DTX on prostate cancer. Our results suggest that chemotherapy combined with oncolytic adenovirus mediated gene therapy is a promising strategy for the treatment of advanced prostate cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Li-jun Mao, Meng Ding, Kai Xu, Jun Pan, Haiyuan Yu, Chunhua Yang Tags: Research Paper Source Type: research

Outcomes of Laparoscopic Total Gastrectomy for Elderly Gastric Cancer Patients
Purpose: The purpose of this study was to compare the short- and long-term outcomes after laparoscopic total gastrectomy (LTG) between elderly and non-elderly patients with gastric cancer.Methods: A retrospective analysis was performed using clinical and follow-up data from 168 patients treated with LTG for gastric cancer at our institution from January 2010 to December 2017. For this study, the short- and long-term outcomes (including tumor recurrence rate, disease-free survival rate, and overall survival rate) were compared between the elderly group (≥70 years) and non-elderly group (
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shihou Sheng, Yahong Chen, Chunsheng Li Tags: Research Paper Source Type: research

The prognostic value of Cyclin-Dependent Kinase 5 and Protein Phosphatase 2A in Gastric Cancer
Conclusion The expression of CDK5 and PP2A is positively correlated in gastric cancer. Co-expression of CDK5 and PP2A was an independent prognostic factor in patients with gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chang-Ming Huang, Ping Li Tags: Research Paper Source Type: research

Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines
Conclusion: Our results suggest that upregulation of MYOT can be related to TOP resistance in ovarian cancer cell lines. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Karolina Sterzy ń ska, Andrzej Klejewski, Karolina Wojtowicz, Monika Ś wierczewska, Micha ł Nowicki, Jacek Br ą zert, Rados ł aw Januchowski Tags: Research Paper Source Type: research

Age at First Birth and the Risk of Endometrial Cancer Incidence: A Pooled Analysis of Two Prospective Cohort Studies among Japanese Women
Background: Age at first birth has been increasing among women in developed countries. Meanwhile, endometrial cancer has also been increasing worldwide, being one of the most common female hormone-related cancers. The purpose of this study was to examine the association between age at first birth and the risk of endometrial cancer among Japanese women, and to examine the hypothesis that the recent increase in endometrial cancer incidence can be partly explained by the trend for increasing age at first birth.Methods: We conducted a pooled analysis of two prospective studies among residents in Miyagi Prefecture in rural nort...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yumi Sugawara, Kemmyo Sugiyama, Yasutake Tomata, Seiki Kanemura, Akira Fukao, Ichiro Tsuji Tags: Research Paper Source Type: research

TFF3 Contributes to Epithelial-Mesenchymal Transition (EMT) in Papillary Thyroid Carcinoma Cells via the MAPK/ERK Signaling Pathway
In this study, the expression of TFF3 and the epithelial-mesenchymal transition (EMT) transcriptional factor Snail in PTC and para-carcinoma specimens was evaluated by immunohistochemistry (IHC) and Western blot, and the possible associations with lymph node (LN) metastasis and other clinicopathological parameters were analysed. In vitro, the effect of TFF3 on the malignant behaviour of TPC-1 cells was evaluated by cell proliferation assays, cell adhesion assays, colony formation assays, wound-healing assays and transwell chamber invasion assays. EMT markers and regulatory molecules were detected by quantitative RT-PCR (qR...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xu Lin, Huiqin Zhang, Jin Dai, Wenjing Zhang, Jing Zhang, Gang Xue, Jingfang Wu Tags: Research Paper Source Type: research

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor
MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. The purposes of this study were to investigate the correlation between the expression of MPHOSPH1 and clinicopathological factors and to examine the efficacy of MPHOSPH1 target therapy in TGCTs. We investigated 75 formalin-fixed paraffin-embedded TGC...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Tatsuro Abe, Kenichi Kohashi, Junkichi Takemoto, Fumio Kinoshita, Masatoshi Eto, Yoshinao Oda Tags: Research Paper Source Type: research

Tenascin-C Modulates Cell Cycle Progression to Enhance Tumour Cell Proliferation through AKT/FOXO1 Signalling in Pancreatic Cancer
In conclusion, TNC exerts its activating effect on the proliferation of pancreatic cancer cells in vitro and in vivo through its functional target AKT/FOXO1/β-catenin. The molecular mechanisms that drive PDAC progression will be useful for the development of molecular markers and the evaluation of patient prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jun Cai, Wenli Lu, Shaoxia Du, Zhongkui Guo, Hui Wang, Wei Wei, Xiaohong Shen Tags: Research Paper Source Type: research

Identification of Grade-associated MicroRNAs in Brainstem Gliomas Based on Microarray Data
Gliomas arising in the brainstem are rare tumours that are difficult to surgically resect, and the microRNAs (miRNAs) and signalling pathways associated with brainstem gliomas (BSGs) are largely unknown. To identify grade-associated miRNAs in BSGs, a microarray analysis of 10 low-grade and 15 high-grade BSGs was performed in this study. Differentially expressed miRNAs (DE-miRNAs) were identified, and the functional DE-miRNAs were selected. The potential target genes and enriched pathways were analysed, and a target gene-associated protein-protein interaction (PPI) network was generated. Grade-associated functional DE-miRNA...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xin Chen, Dezuo Dong, Changcun Pan, Cheng Xu, Yu Sun, Yibo Geng, Lu Kong, Xiong Xiao, Zitong Zhao, Wei Zhou, Lijie Huang, Yongmei Song, Liwei Zhang Tags: Research Paper Source Type: research

Feasibility and Efficacy of Simultaneous Integrated Boost Intensity-modulated Radiation Therapy based on MRI-CT fusion in Patients with Brain Metastases of Non-small Cell Lung Cancer
Conclusion: SIB-IMRT with the dose/fractionation based on the fusion imaging of MRI-CT is feasible and safe. It is beneficial to the NSCLC patients with BM and can reduce the overall costs of treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yinping Dong, Yanke Zhang, Tianyi Zhang, Min Fan, Jian Zhu, Baosheng Li, Wei Huang Tags: Research Paper Source Type: research

Identification of Five Genes as a Potential Biomarker for Predicting Progress and Prognosis in Adrenocortical Carcinoma
Background: Adrenocortical carcinoma (ACC) is a limited endocrine fatality with a minor diagnosis and rare remedial options. The progressive and predictive meaning of message RNA (mRNA) expression oddity in ACC has been studied extensively in recent years. However, differences in measurement platforms and lab protocols as well as small sample sizes can render gene expression levels incomparable.Methods: An extensive study of GEO datasets was conducted to define potential mRNA biomarkers for ACC. The study compared the mRNA expression profiles of ACC tissues and neighboring noncancerous adrenal tissues in the pair. The stud...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: He Xiao, Deqiang Xu, Ping Chen, Guang Zeng, Xinghuan Wang, Xinhua Zhang Tags: Research Paper Source Type: research

GFAP expression is influenced by astrocytoma grade and rs2070935 polymorphism
Glial fibrillary acidic protein (GFAP) is an intermediate filament that provides mechanical support to astrocytes. Rs2070935 is a single nucleotide polymorphism (SNP) located in the promoter region of the GFAP gene. The aim of this pilot study is to investigate GFAP expression at mRNA, protein levels and rs2070935 polymorphism in 50 different grade human astrocytoma samples. GFAP expression at mRNA level was measured using quantitative reverse transcription polymerase chain reaction (qRT-PCR) with SYBR Green dye, whereas the translational activity of the following gene was detected using western blot assay. Furthermore, ge...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Mantas Sereika, Ruta Urbanaviciute, Arimantas Tamasauskas, Daina Skiriute, Paulina Vaitkiene Tags: Research Paper Source Type: research

Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth
Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human malignancies, particularly Kaposi's Sarcoma (KS), which preferentially arise in immunocompromised patients such as HIV+ subpopulation while still lacking of effective therapeutic options. We recently found that the ribonucleotide reductase (RR) subunit M2 is potentially regulated by the key oncogenic HGF/c-MET pathway in KSHV-related lymphoma cells. One of RR inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) effectively induced apoptosis of KSHV+ lymphomas and suppressed tumor progression in vivo. In the current study,...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Lu Dai, Jungang Chen, Yueyu Cao, Luis Del Valle, Zhiqiang Qin Tags: Research Paper Source Type: research

The Efficacy and Safety of Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Nasopharyngeal Carcinoma: Literature-based Meta-analyses
Conclusion: We recommend anti-EGFR mAbs enhance—but should not replace—current treatment paradigms for locoregionally advanced NPC. Further evidence from phase III clinical trials is required. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Liang Peng, Ze-Long Liu, Cheng Xu, Ling-Long Tang, Xu Liu, Ai-Hua Lin, Ying Sun, Yu-Pei Chen, Jun Ma Tags: Research Paper Source Type: research