MiR-543 promotes cell proliferation and metastasis of renal cell carcinoma by targeting Dickkopf 1 through the Wnt/ β -catenin signaling pathway
Conclusion: Our study indicated that miR-543 negatively regulate the expression of DKK-1 in vitro. MiR-543 promotes malignancy phenotypes of RCC both in vitro and in vivo. This regulatory effect of miR-543 may be associated with Wnt/β-catenin signaling pathway. Therefore, miR-543 could be used as a biomarker for predicting the progression of RCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhi-yuan Chen, Yang Du, Lei Wang, Xiu-heng Liu, Jia Guo, Xiao-dong Weng Tags: Research Paper Source Type: research

Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs
Accumulating studies confirmed that luteolin, a common dietary flavonoid which is widely distributed in plants and has diverse beneficial biological function, including anti-oxidant, anti-inflammation and anticancer properties. However, the detail mechanisms of luteolin on GC are poorly understood. Here, we investigated the anticancer effect of luteolin in GC cells in vitro and in vivo. Luteolin reduced the cell viability in a time and dose-dependent manner. Luteolin significantly inhibited cell cycle progress, colony formation, proliferation, migration, invasion and promoted apoptosis in vitro and in vivo. Luteolin also r...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yansong Pu, Tao Zhang, Jianhua Wang, Zhijun Mao, Baojun Duan, Yanbin Long, Fei Xue, Dong Liu, Sida Liu, Zengzhan Gao Tags: Research Paper Source Type: research

Neoadjuvant Chemotherapy with Fluorouracil plus Nedaplatin or Cisplatin for Locally Advanced Nasopharyngeal Carcinoma: a Retrospective Study
In this study, a total of 186 patients with locally advanced NPC between January 2009 and November 2011 in our center were retrospectively analyzed. 103 cases were received NF neoadjuvant chemotherapy followed by nedaplatin concurrent intensity-modulated radiotherapy (IMRT), and 83 cases were received PF neoadjuvant chemotherapy followed by cisplatin concurrent IMRT. Overall survival (OS), progression-free survival (PFS), local relapse-free survival (LRFS), regional relapse-free survival (RRFS) and distant metastasis-free survival (DMFS), as well as acute toxicities were monitored. Results showed that there were no signifi...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Tongxin Liu, Quanquan Sun, Jing Chen, Bin Li, Weifeng Qin, Fangzheng Wang, Zhimin Ye, Fujun Hu Tags: Research Paper Source Type: research

How much margin do we need for pelvic lymph nodes irradiation in the era of IGRT?
Conclusions: IGRT could reduce setup errors. IGRT with 6D treatment couches could further reduce setup errors compared to 3D couches. For centers without IGRT, we suggest CTV-PTV margins of 6 mm, 9 mm and 12 mm in LR, AP and SI directions respectively, margins of 3 mm, 6.5 mm and 7 mm for the use of daily IGRT with 3D couch and 2 mm, 3 mm and 3 mm for 6D couch. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhikai Liu, Xia Liu, Fuquan Zhang, Ke Hu Tags: Research Paper Source Type: research

The prognostic value of long noncoding RNA ZEB1-AS1 on clinical outcomes in human cancer
Conclusions: High ZEB1-AS1expression was associated poor clinical outcome and it can serve as a novel predictive biomarker in various cancers. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ying Wu, Ming Ding, Shuzhen Wei, Ting Wu, Rongrong Xu, Xiaoli Zhu, Hongbing Liu Tags: Research Paper Source Type: research

Oncogenic virus-induced aerobic glycolysis and tumorigenesis
Enhanced glycolysis under normoxic conditions is known as aerobic glycolysis or the Warburg effect and is a hallmark of many tumors. Viral infection may also induce aerobic glycolysis as it is required for replication and survival. Tumor viruses inducing aerobic glycolysis and lactate production during latent infection suggest a potential role of virus-induced glycolysis in tumorigenesis. Virus or virus-encoded proteins regulate glucose uptake and lactate export, increase the activity of glycolytic enzymes, and modulate glucose metabolic signals. Accumulating evidence suggests that virus-induced glycolysis may facilitate c...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Li Yu, Xun Chen, Liantang Wang, Shangwu Chen Tags: Review Source Type: research

Survival analysis for lung adenosquamous carcinoma patients with brain metastasis
Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients.Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 2008 and December 31, 2010 at the Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University were retrospectively reviewed. Time to BM (TTB) and overall survival (OS) data were analyzed. OS1 was calculated from the time ASC was diagnosed until the death of a patient. OS2 was define...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Feng Pan, Shaohua Cui, Weimin Wang, Aiqin Gu, Liyan Jiang Tags: Research Paper Source Type: research

Preoperative Serum and Intra-platelet Serotonin in Prognosis: Useful or Useless?
(Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qinling Yang, Sushun Liu, Chaoling Deng, Bo Shu, Jingyao Zhang, Mimi Zhai Tags: Letter Source Type: research

LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1
In conclusion, we found that miR-149 downregulated ZBTB2 and SP1 expressions, and inhibited GC cell progression mediated by GACAT1. Therefore, we indicated that GACAT1 and miR-149 may be potential therapeutic targets for GC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiaoqing Shi, Xiaoqin Wang, Yimin Hua Tags: Research Paper Source Type: research

Nucleolar stress: is there a reverse version?
The nucleolus is a dynamic structure that has roles in various physiological and pathophysiological processes. Perturbations on many aspects of the nucleolar functions are thought to cause “nucleolar stress”, which occurs in response to a variety of chemotherapeutic drugs. The main characteristic changes of nucleolar stress include: 1) reduction of the size and volume of the nucleolus; 2) inhibition of RNA Pol I-mediated rRNA synthesis; and 3) nucleoplasmic translocation of nucleolar stress-related proteins. In studying the apoptosis-inducing effect of the natural compound lovastatin (LV) on breast cancer stem ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Lu Lu, Huimei Yi, Chao Chen, Shichao Yan, Hui Yao, Guangchun He, Guifei Li, Yiqun Jiang, Tuo Deng, Xiyun Deng Tags: Short Research Communication Source Type: research

Breast cancer stem cell markers CD44 and ALDH1A1 in serum: distribution and prognostic value in patients with primary breast cancer
This study included 140 primary breast cancer patients with stage I-III. Serum samples were collected before surgery and stored at -80 degrees. CD44 and ALDH1A1 were measured by chemiluminescent assay.Results: High serum CD44 levels (≥ 417.4 ng/mL) were correlated with postmenopausal status (P = 0.006), estrogen receptor negativity (P = 0.025), progesterone receptor negativity (P = 0.002) and adjuvant chemotherapy (P = 0.003). The mean serum CD44 levels of luminal group (406.4 ± 68.3 ng/mL) were significantly lower than triple negative group (506.8 ± 175.5 ng/mL) (P
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yanan Kong, Ning Lyu, Jiali Wu, Hailin Tang, Xinhua Xie, Lu Yang, Xing Li, Weidong Wei, Xiaoming Xie Tags: Research Paper Source Type: research

Activated Tumor-infiltrating Fibroblasts Predict Worse Prognosis in Breast Cancer Patients
Conclusion: The infiltration of activated fibroblasts, especially the FSP-1+ or podoplanin+ fibroblasts leads to worse clinical outcome in breast cancer patients, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Guoming Hu, Feng Xu, Kefang Zhong, Shimin Wang, Liming Huang, Wei Chen Tags: Research Paper Source Type: research

Paired box 2 promotes progression of endometrial cancer via regulating cell cycle pathway
Conclusions: PAX2, though influencing the expression of CDK1, promotes the proliferation, enhances the mobility of endometrial cancer cells, thus exerts an important role in the carcinogenesis of endometrial cancer. PAX2 may be a potential therapeutic target for endometrial cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jieyu Wang, Nan Jia, Tianjiao Lyv, Chao Wang, Xiang Tao, KwongKwok Wong, Qin Li, Weiwei Feng Tags: Research Paper Source Type: research

Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells
Cervical cancer is one of the most common cancer in female worldwide. The expression of high-risk human papillomavirus E7 oncogene is necessary for the maintenance of malignant phenotypes and transformation. Accumulating studies of this protein has been explored in cervical cancer, however, there are fewer studies on how E7 expression affects the expression of global circular RNA. CircRNA, a promising biomarker and even therapeutic target, has become a star molecular in research after miRNA and long non-coding RNA. Our aim of this study was to investigate the global circRNA levels modulated by HPV E7 expression and identif...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Si-Rong Zheng, Han-Rong Zhang, Zhen-Fei Zhang, Shu-Yu Lai, Li-Jun Huang, Jie Liu, Xin Bai, Ke Ding, Jue-Yu Zhou Tags: Research Paper Source Type: research

MicroRNA-34 family in breast cancer: from research to therapeutic potential
MicroRNA (miRNA)-34 family (miR-34s), including miR-34a/b/c, is the most well studied non-coding RNAs that regulate gene expression post-transcriptionally. The miR-34s mediates the tumor suppressor function of p53 in the pathogenesis of breast cancer by targeting different oncogenes. This review focuses on the anti-oncogenic regulation of the miR-34s, emphasizing the major signaling pathways that are involved in the modulation of miR-34s in breast cancer. Moreover, it highlights how epigenetic modification by the p53/miR-34s axis regulates the proliferation, invasiveness, chemoresistance, and sternness of breast cancer. A ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Saber Imani, Ray-Chang Wu, Junjiang Fu Tags: Review Source Type: research

miR-29b negatively regulates MMP2 to impact gastric cancer development by suppress gastric cancer cell migration and tumor growth
MicroRNAs (miRNAs) are important regulators and associated with the development of many different types of cancer, including gastric cancer. However, their pathophysiologic role and their relevance to tumorigenesis, invasion and metastasis are still unknown. In our current study, we performed microRNA array and found that 28 of miRNAs were differentially expressed in INF type of gastric cancer. Among 28 miRNAs, miR-29b was one of the most significantly down-regulated miRNA. Further bioinformatics analysis showed that MMP2 was a potential target of miR-29b. Interestingly, luciferase analysis showed that miR-29b negatively r...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Tao Wang, Jingjing Hou, Shuo Jian, Qicong Luo, Jie Wei, Zengpeng Li, Xuegang Wang, Peide Bai, Bo Duan, Jinchun Xing, Jianchun Cai Tags: Research Paper Source Type: research

EZH2 Expression is increased in BAP1-mutant renal clear cell carcinoma and is related to poor prognosis
Conclusion: CcRCC with decreased BAP1 level has poor prognosis and is associated with higher EZH2 expression. Inhibition of EZH2 in BAP1-mutated entity holds promise for further investigation. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chenmin Sun, Chunchun Zhao, Shugen Li, Jianqing Wang, Qidong Zhou, Jianliang Sun, Qiang Ding, Min Liu, Guanxiong Ding Tags: Research Paper Source Type: research

Research progress on the impact of radiation on TKI resistance mechanisms in NSCLC
Resistance to tyrosine kinase inhibitor (TKI) therapy is often accompanied by various genetic alterations, and radiation is an important weapon for changing the DNA of tumor cells. In radiotherapy combined with TKI therapy for non-small cell lung cancer (NSCLC), the two treatment strategies affect and interact with each other, resulting in complex tumor resistance mechanisms. Accordingly, tumor progression management after radiotherapy combined with TKI therapy should be different from that after TKI therapy alone. However, current clinical practice is entirely based on the resistance mechanisms of simple TKI therapy. Ther...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hongqing Zhuang Tags: Review Source Type: research

Oestrogen Inhibits VEGF Expression And Angiogenesis In Triple-Negative Breast Cancer By Activating GPER-1
In this study, we found that treatment with 17β-oestradiol (E2) inhibited VEGF mRNA and protein expression in the TNBC cell lines MDA-MB-468 and MDA-MB-436. To further elaborate on the phenomenon of E2-regulated angiogenesis, we showed that conditioned medium from the TNBC cell line MDA-MB-468 treated with E2 inhibits the tube formation ability of human umbilical vein endothelial cells (HUVECs). Additionally, the G-protein-coupled oestrogen receptor-1 (GPER-1)-specific agonist G-1 has a function similar to that of E2. While G-15, the selective antagonist of GPER-1, notably reversed the inhibitory effects of E2 and G-1...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chen Wang, Jiehao Li, Shuang Ye, Yaxing Zhang, Ping Li, Ling Wang, Ting-huai Wang Tags: Research Paper Source Type: research

Multiplex Cell-Free DNA Reference Materials for Quality Control of Next-Generation Sequencing-Based In Vitro Diagnostic Tests of Colorectal Cancer Tolerance
Conclusions: These results indicated that these cfDNA RMs would be pivotal for NGS-based cancer IVDs, especially for liquid biopsies of colorectal cancer-related mutations and would guide the further development of RMs covering more onco-related mutations. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Donglai Liu, Xinyuan Zhang, Haiwei Zhou, Xiaojing Lin, Dawei Shi, Shu Shen, Yabin Tian, Bo Du, Henghui Zhang, Haibo Wang, Youchun Wang, Chuntao Zhang Tags: Research Paper Source Type: research

The value of long noncoding RNA CASC2 as a biomarker of prognosis in carcinomas: a meta-analysis
Lnc RNA Cancer Susceptibility Candidate 2(CASC2) has been shown to be aberrantly expressed in multiple types of cancer and might serve as a prognosis biomarker. The present meta-analysis was conducted to investigate whether the expression of CASC2 was associated with prognosis or clinicopathological features in correlative cancers. A total of 11 studies with 765 cancer patients were included by searching the electronic databases, the results found a significant association between high expression of CASC2 and longer OS in cancer patients (HR=0.43, 95% CI: 0.33-0.55, P =0.000).In addition, a significant correlation was obse...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xin Yan, Yanting Zhu, Fangwei Li, Wenhua Shi, Jian Wang, Qingting Wang, Qianqian Zhang, Limin Chai, Manxiang Li Tags: Research Paper Source Type: research

Retroperitoneal dedifferentiated liposarcoma: Analysis of 61 cases from a large institution
Conclusion: Intermediate-grade histology, intraoperative blood loss
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Peng Luo, Weiluo Cai, Lingge Yang, Zhiqiang Wu, Yong Chen, Ruming Zhang, Wangjun Yan, Yingqiang Shi, Chunmeng Wang Tags: Research Paper Source Type: research

S100A4-MYH9 Axis Promote Migration and Invasion of Gastric Cancer Cells by Inducing TGF- β -Mediated Epithelial-Mesenchymal Transition
In conclusion, overexpression of S100A4 and downstream molecular MYH9 in advanced gastric cancer predicted poor prognosis; oncogene S100A4 facilitate EMT process induced by TGF-β stimulation, suggesting a potential target in management of peritoneal metastasis of gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Fengping Li, Jiaolong Shi, Zhijun Xu, Xingxing Yao, Tingyu Mou, Jiang Yu, Hao Liu, Guoxin Li Tags: Research Paper Source Type: research

Prolonging Gastrointestinal-Stromal-Tumor-free life, an optimal suggestion of imatinib intervention ahead of operation
Conclusion: In conclusion, as for regressing tumor progression and creating operative chance, preoperative imatinib should be considered for the patients with high risk, although the precise duration of this intervention needs further validation. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Lin-Hai Yan, Zhi-Ning Chen, Chun-Jun Li, Jia Chen, Yu-Zhou Qin, Jian-Si Chen, Wei-Zhong Tang Tags: Research Paper Source Type: research

Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females
Although genome-wide association studies (GWASs) have identified some risk single-nucleotide polymorphisms in East Asian never-smoking females, the unexplained missing heritability is still required to be investigated. Runs of homozygosity (ROHs) are thought to be a type of genetic variation acting on human complex traits and diseases. We detected ROHs in 8,881 East Asian never-smoking women. The summed ROHs were used to fit a logistic regression model which noteworthily revealed a significant association between ROHs and the decreased risk of lung cancer (P
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yi-Xiao Chen, Yan Guo, Shan-Shan Dong, Xiao-Feng Chen, Jia-Bin Chen, Yu-Jie Zhang, Shi Yao, Hlaing Nwe Thynn, Liqiang Zhi, Tie-Lin Yang Tags: Research Paper Source Type: research

microRNA biomarkers in colorectal cancer liver metastasis
Liver metastasis is a primary factor of prognosis and long-term survival for patients diagnosed with colorectal cancer (CRC). Colorectal cancer liver metastasis (CRCLM), is a complex biological process involving multiple factors and steps, and its mechanisms are yet to be discovered. In recent years, small noncoding RNAs, especially microRNAs (miRNAs) have been proven to play an important role in tumorigenesis, progression and metastasis in a variety of cancers, including CRC. Increasing evidence suggests that miRNAs, including those from exosomes secreted by tumor cells in circulation, could be used as promising biomarker...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shulin Huang, Xiaohui Tan, Zhongcheng Huang, Zihua Chen, Paul Lin, Sidney W. Fu Tags: Review Source Type: research

Ethanol Enhances Estrogen Mediated Angiogenesis in Breast Cancer
In this study, we defined the in vitro effects of the combination of estrogen and alcohol in breast cancer angiogenesis using the tubulogenesis and scratch wound assays. Conditioned media, generated by culturing the murine mammary cancer cell line, TG1-1, in estrogen and ethanol, enhanced tubule formation and migration as well as modulated the MAP Kinase pathway in the murine endothelial cell line, SVEC4-10. Additionally, estrogen and ethanol in combination enhanced the expression of the pro-angiogenic factors VEGF, MMP-9, and eNOS, and modulated Akt activation. These observations suggest that TG1-1 cells secrete pro-angio...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Rachana Maniyar, Sanjukta Chakraborty, Robert Suriano Tags: Research Paper Source Type: research

Impact of the Receptor for Advanced Glycation End Products Genetic Polymorphisms on the Progression in Uterine Cervical Cancer
In conclusion, RAGE SNPs rs1800624 was associated with some clinicopathological variables in cervical cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chung-Yuan Lee, Soo-Cheen Ng, Yi-Hsuan Hsiao, Shun-Fa Yang, Chun-Fang Hsu, Po-Hui Wang Tags: Research Paper Source Type: research

Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary
A query regarding the definition and the classification of solitary plasmacytoma is apparently still pending. The clinical course, the response to treatment and the propensity to progress to plasma cell myeloma, are all a function of the classification which must be established on a firm basis. Solitary plasmacytoma should be recognized in the continuum of the plasma cell neoplasms. Moreover, whether the solitary plasmacytoma of bone and the extramedullary type of the tumor represent two distinct disease entities, exhibiting separate biological characteristics, has not been finally established. To appraise the similarities...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Nissim Ohana, Ory Rouvio, Karen Nalbandyan, Dimitri Sheinis, Daniel Benharroch Tags: Review Source Type: research

The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer
This study aimed to explore the mechanism of lung metastases of colorectal cancer. The expression of CXCR4, CXCR7, and CXCL12 in colorectal cancer and lung metastases was analyzed by the immunohistochemical (IHC) method. Further, the study aimed at getting new insights into the role of CXCL12 in lung metastasis. A total of 41 patients who underwent surgical resections for both colorectal cancer and lung metastasis were retrospectively selected for this study. Also, 41 patients who underwent lung resection for benign lung disease were selected as the control group. In the in vivo experiment, the mice were injected with exos...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Meng Wang, Xuyang Yang, Mingtian Wei, Ziqiang Wang Tags: Research Paper Source Type: research

Prognostic Value of Plasma Fibrinogen in Lung Cancer Patients: A Meta-Analysis
Background: The prognostic role of plasma fibrinogen in lung cancer remains controversial. The aim of this meta-analysis was to assess the prognostic value of plasma fibrinogen in lung cancer.Methods: We performed a systematic literature search to identify eligible studies in PubMed, Embase and the Cochrane Library database. The hazard ratios (HR) and their 95% confidence intervals (CI) were collected from these eligible studies and were used to assess the relationship between plasma fibrinogen and lung cancer.Results: A total of 16 studies including 6,881 patients were selected in this meta-analysis. The results showed th...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hai Zhong, Yingying Qian, Surong Fang, Ying Wang, Yun Tang, Wei Gu Tags: Research Paper Source Type: research

Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associated with Smoking by Co-Expression Network Analysis
Although it is well known that smoking is one of pathogenesis of clear cell renal cell carcinoma (ccRCC), the underlying molecular mechanism is still unclear. In our study, the microarray dataset GSE46699 is analyzed by weighted gene co-expression network analysis (WGCNA). Then we identify 15 co-expressed gene modules in which the lightcyan module (R2 = 0.30) is the most significant. Combined with the protein-protein interaction (PPI) network and WGCNA, two hub genes are identified. Meanwhile, linear regression analyses indicate that TOP2A has a higher connection with smoking in ccRCC, survival analysis proved that overexp...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yaoyi Xiong, Lushun Yuan, Liang Chen, Yuan Zhu, Shanshan Zhang, Xuefeng Liu, Yu Xiao, Xinghuan Wang Tags: Research Paper Source Type: research

A Prognostic Nomogram for Cervical Cancer after Surgery from SEER Database
Conclusions: By incorporating LODDS, our nomogram may be superior to the currently utilized FIGO staging system in predicting OS in cervical cancer patients after surgery. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ce Wang, Chunyan Yang, Wenjie Wang, Bairong Xia, Kang Li, Fengyu Sun, Yan Hou Tags: Research Paper Source Type: research

FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer
The Fez family zinc finger protein 1 (FEZF1), a critical transcription factor in nervous system development, has been implicated in cancer progression recently. However, its clinical significance remains unknown. By analyzing gene expression data of eight most common cancer types from The Cancer Genome Atlas (TCGA), we found that FEZF1 prominently associated with the recurrence-free survival of cervical cancer patients (P
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yang Lan, Xuewei Xiao, Yu Luo, Zhengchi He, Xu Song Tags: Research Paper Source Type: research

Overexpression of Peroxiredoxin 6 (PRDX6) Promotes the Aggressive Phenotypes of Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies. Peroxiredoxin 6 (PRDX6), a member of peroxidase superfamily, has a function of eliminating the reactive oxygen species (ROS), and participates in development of multiple diseases, including tumors. The purpose of this study was to investigate the expression of PRDX6 in normal and cancerous esophageal tissues and to characterize its role in ESCC progression. We found significantly higher expression of PRDX6 in ESCC tissues than in normal esophageal tissues or tumor-adjacent tissues and that the PRDX6 expression level was positively correlated ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yan He, Wanglei Xu, Yuji Xiao, Lu Pan, Guangxia Chen, Yiting Tang, Jundong Zhou, Jinchang Wu, Wei Zhu, Shuyu Zhang, Jianping Cao Tags: Research Paper Source Type: research

CDK5 Functions as a Tumor Promoter in Human Lung Cancer
Cyclin-dependent kinase 5 (CDK5), an atypical member of the cyclin-dependent kinase family, plays an important role in the nervous system. Recent studies have shown that CDK5 is also associated with tumors. However, few studies have been done to investigate the mechanism underlying the connection between CDK5 and cancers. To explore the role of CDK5 in cancers by using an extensive bioinformatics data mining process. We mined the transcriptional, survival, functions and structure of CDK5 gene through databases and in vitro experiments. We found that higher CDK5 expression levels in most cancer cell lines while lower expres...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jie Zeng, Shuanshuan Xie, Yang Liu, Changxing Shen, Xiaolian Song, Guo-Lei Zhou, Changhui Wang Tags: Research Paper Source Type: research

Huaier Augmented the Chemotherapeutic Sensitivity of Oxaliplatin via Downregulation of YAP in Hepatocellular Carcinoma
For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) is an effective treatment of HCC after sorafenib treatment failure. However, the intrinsic or acquired resistance of Oxa affected the chemotherapeutic sensitivity. By analyzing the data of GEO Database, we found that Oxa aberrantly increased the expression of Cysteine-rich61 (Cyr61) in HCC cell lines. Subsequently, in Bel-7404 and SMMC-7721 cells after treated with Oxa, it was verified that the expression of Cyr61 and Yes-associated protein (YAP) was increased. Moreover, we found that blockade of YAP pr...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yuquan Tao, Liang Shan, Xin Xu, Hongyuan Jiang, Rui Chen, Zijun Qian, Zongguo Yang, Bin Liang, Haiyin Zheng, Feng Cai, Yongchun Yu, Lifang Ma Tags: Research Paper Source Type: research

Multiple Machine Learnings Revealed Similar Predictive Accuracy for Prognosis of PNETs from the Surveillance, Epidemiology, and End Result Database
Conclusions: The models developed with machine learning performed well in survival prediction of PNETs, and the DL model have a better accuracy and specificity than the AJCC staging system in SEER data. The DL model has potential for clinical application but external validation is needed. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yiyan Song, Shaowei Gao, Wulin Tan, Zeting Qiu, Huaqiang Zhou, Yue Zhao Tags: Research Paper Source Type: research

Tumor deposit is an independent prognostic indicator in patients who underwent radical resection for colorectal cancer
Background: Tumor deposits are one of the promising factors among the different edition of Tumor, Node, Metastasis classification. Despite improvement in the treatment of various types of metastatic disease the source and prognostic significance of tumor deposits in staging has not been deliberating the agreeable opinion. We investigated the possibility of tumor deposit as independent prognostic factor and evaluating its prognostic value in colorectal carcinoma patients.Methods: Author studied 313 colorectal cancer patients clinocopathological data and outcome who underwent radical resection. Data between 2011-2015 were re...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shiva Basnet, Qi-feng Lou, Nan Liu, Ramesh Rana, Abilasha Shah, Mamata Khadka, Hemanshu Warrier, Shushil Sigdel, Sunil Dhakal, Anita Devkota, Roshan Mishra, Ganga Sapkota, Liang Zheng, Hai-yan Ge Tags: Research Paper Source Type: research

A nomogram to predict long-time survival for patients with M1 diseases of esophageal cancer
Conclusions: Married patients, patients with well differentiated tumors, patients with oligometastatic site, patients without bone metastasis or liver metastasis and those who underwent surgery are associated with long time survivals. We developed a nomogram predicting 1- and 2-year OS and CSS for M1 stage esophageal cancer. The prognostic model may improve clinicians' abilities to predict individualized survival and to make treatment recommendations. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Mina Liu, Changlu Wang, Lanting Gao, Changxing Lv, Xuwei Cai Tags: Research Paper Source Type: research

Serum level of co-expressed hub miRNAs as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma
Conclusions: The association of specific Hub miRNAs with the development of pancreatic cancer was established by WGCNA analysis. Five miRNAs (mir-16-2-3p, mir-890, mir-3201, mir-602, and mir-877) were identified as potential diagnostic and prognostic biomarkers for PDAC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qiang Su, Emily C Zhu, Yao-long Qu, Di-ya Wang, Wei-wei Qu, Chen-guang Zhang, Ting Wu, Zu-hua Gao Tags: Research Paper Source Type: research

The efficacy and safety of long- versus short-interval transarterial chemoembolization in unresectable hepatocellular carcinoma
Background: To compare the efficacy and safety of long- versus short-interval of transarterial chemoembolization (TACE) in unresectable hepatocellular carcinoma (HCC) patients.Methods: This retrospective analysis enrolled 574 patients with unresectable HCC who underwent at least two sessions of TACE between January 2007 and December 2014. The patients were divided into a short-interval group (SIG) and a long-interval group (LIG) based on the median TACE interval of the first two sessions. Propensity score matching (PSM) identified 476 patients for a comparison of overall survival (OS) and safety.Results: Before matching, t...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhi-Wen Yang, Wei He, Yun Zheng, Ru-Hai Zou, Wen-Wu Liu, Yuan-Ping Zhang, Chen-Wei Wang, Yong-Jin Wang, Yi-Chuan Yuan, Bin-Kui Li, Yun-Fei Yuan Tags: Research Paper Source Type: research

Cause-specific mortality prediction model for patients with basaloid squamous cell carcinomas of the head and neck: a competing risk analysis
Conclusions: We built the first competing risk nomogram for HNBSCC. The model performance was found to be good. This individualized prognostic predictive tool will aid physicians in clinical counseling, and will assist patients in planning for their future lives. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Weidong Shen, Naoko Sakamoto, Limin Yang Tags: Research Paper Source Type: research

Roles of Smads Family and Alternative Splicing Variants of Smad4 in Different Cancers
Transforming Growth Factor β (TGF-β) is one of the most common secretory proteins which are recognized by membrane receptors joined to transcription regulatory factor. TGF-β signals are transduced by the Smads family that regulate differentiation, proliferation, early growth, apoptosis, homeostasis, and tumor development. Functional study of TGF-β signaling pathway and Smads role is vital for certain diseases such as cancer. Alternative splicing produces a diverse range of protein isoforms with unique function and the ability to react differently with various pharmaceutical products. This review organiz...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Irfan Ullah, Weichao Sun, Liling Tang, Jianguo Feng Tags: Review Source Type: research

CIP2A Promotes Proliferation, Invasion and Chemoresistance to Cisplatin in Renal Cell Carcinoma
CIP2A is a well-known oncoprotein whose expression is elevated in multiple human solid tumor types. However, its role in renal cell carcinoma (RCC) development is poorly understood. Thus, in our present study, we used the renal cancer cell lines 786-O, A498 and CAKI-1 and the renal epithelial cell line HK-2 to clarify the function of CIP2A in RCC. We found that CIP2A expression is much higher in the RCC cells than in the normal renal epithelial cell. Lentivirus covered coding region CIP2A cDNA sequence and CIP2A siRNA were used to up and down regulate CIP2A expression in vitro. We found that overexpression of CIP2A promote...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yongzhen Zhang, Liang Fang, Yuanwei Zang, Juchao Ren, Zhonghua Xu Tags: Research Paper Source Type: research

Tongue Coating Microbiota Community and Risk Effect on Gastric Cancer
Conclusion: Microbiome in tongue coating may have potential guiding value for early detection and prevention of GC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Juan Wu, Shuo Xu, Chunjie Xiang, Qinhong Cao, Qiyi Li, Jiaqian Huang, Liyun Shi, Junfeng Zhang, Zhen Zhan Tags: Research Paper Source Type: research

VEGFR-2 Inhibitor Apatinib Hinders Endothelial Cells Progression Triggered by Irradiated Gastric Cancer Cells-derived Exosomes
Conclusion / Significance: Combining radiotherapy and VEGFR inhibitors treatment can provide potentially a substantial impact in decreasing cancer death rates by averting the negative effect of radiotherapy regiments and provide better standard for cancer patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Guangxin Li, Haishan Lin, Ruyue Tian, Pengfei Zhao, Yongjie Huang, Xinqiao Pang, Lei Zhao, Bangwei Cao Tags: Research Paper Source Type: research

Development of a Novel Autophagy-related Prognostic Signature for Serous Ovarian Cancer
Conclusions: Our findings suggest that the eight-gene autophagy-related signature could serve as an independent prognostic indicator for cases of serous ovarian cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yuanyuan An, Fangfang Bi, Yue You, Xinhui Liu, Qing Yang Tags: Research Paper Source Type: research

Cytoplasmic SQSTM1/ P62 Accumulation Predicates a Poor Prognosis in Patients with Malignant Tumor
Aims: SQSTM1/p62, as an autophagy marker, is a key molecule involved in the autophagy process. Recent studies have demonstrated that p62 has a close relationship with tumorigenesis and progression, but the impact of p62 on patients' survival has not been comprehensively understood. Therefore, we conducted this study to assess the expression level of p62 in tumor cells and the prognostic role of p62 expression in various malignant tumors.Methods: We searched PubMed, PubMed Central (PMC), Embase, Ovid and Web of Science databases and identified 30 eligible studies containing 14,072 patients to include in the meta-analysis. T...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Linhai Zhu, Yiqing Wang, Jing He, Jie Tang, Wang Lv, Jian Hu Tags: Research Paper Source Type: research

Impact of the Time Interval from Neoadjuvant Chemotherapy to Surgery in Primary Ovarian, Tubal, and Peritoneal Cancer Patients
Neoadjuvant chemotherapy (NACT) plays an important role in ovarian cancer. The appropriate time interval from the completion of NACT to interval debulking surgery (TTS) in ovarian cancer is still unknown. The aim of this retrospective study was to evaluate the effect of the time interval between the end of NACT and surgery (TTS ≤ 4 weeks vs TTS> 4 weeks) on the survival outcomes among patients with advanced-stage ovarian, tubal, and peritoneal cancers. 152 patients with stage III or IV ovarian, tubal, and peritoneal cancers were included in this retrospective cohort study: 115 in the TTS ≤4 weeks and 37 in the TTS...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ming Chen, Zhanpeng Chen, Manman Xu, Duo Liu, Tianyu Liu, Mian He, Shuzhong Yao Tags: Research Paper Source Type: research