Establishment and Characterization of gc-006-03, a Novel Human Signet Ring Cell Gastric Cancer Cell Line Derived from Metastatic Ascites
In this study, we established and characterized a novel SRCGC cell line, gc-006-03.The cells showed a tendency to pile up without contact inhibition. G-band karyotypes of gc-006-03 were revealed hypotriploid with a modal chromosome number of 51. Immunohistochemistry analysis showed that the cells were positive for CEA, CK7, CDX2 and Ki-67(45%), and negative for CK20, TTF1and Li-cadherin. Flow cytometry analysis showed that gc-006-3 had 25% of CD44+ cells. The cells possessed strong clonality and high plating efficiency, and the doubling time was 36h. The cells grew vigorously for more than 100 passages in serial culture. M...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xinyu Su, Yiqi Xue, Jingsun Wei, Xinying Huo, Yang Gong, Honghong Zhang, Rongbo Han, Yuetong Chen, Hong Chen, Jinfei Chen Tags: Research Paper Source Type: research

Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo
In this study, we found that scutellarin significantly inhibited the proliferation of NSCLC cells, induced cell apoptosis, and triggered autophagy. Notably, inhibition of autophagy with inhibitor HCQ attenuated the anti-proliferative activity of scutellarin, indicating that scutellarin-induced autophagy is antineoplastic. In addition, HCQ treatment reduced scutellarin-induced apoptosis. Further study demonstrated that scutellarin stimulated phosphorylation of ERK1/2, and inhibition of ERK1/2 with inhibitor U0126 markedly attenuated scutellarin-induced autophagy. Similarly, scutellarin downregulated the expression of p-AKT,...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: ChaoYue Sun, CaiYun Li, XiaoFeng Li, Ying Zhu, ZuQing Su, XieQi Wang, QingLian He, GuangJuan Zheng, Bing Feng Tags: Research Paper Source Type: research

Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability
Understanding the functional significance of the essential elements in maintaining genomic stability provides insights into the process of tumor initiation and progression, and predicts therapeutic responses. One such element that has recently attracted significant attention is the Speckle-Type Poz Protein (SPOP), an E3 ubiquitin ligase adaptor protein. SPOP is frequently mutated or has altered expression in various cancers, including prostate, renal and endometrial. SPOP is involved in the regulation of proteasome-mediated degradation of several oncoproteins. Moreover, recent data also indicate SPOP's direct involvement i...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xi Wei, Joshua Fried, Ying Li, Linfei Hu, Ming Gao, Sheng Zhang, Bo Xu Tags: Review Source Type: research

Comparison of treatment plan quality of VMAT for esophageal carcinoma with: flattening filter beam versus flattening filter free beam
Conclusions: For esophageal carcinoma, the research showed that the treatment plans with FFF beams could get comparable dose distribution in targets and could significantly reduce the peripheral dose around targets compared to the plans with FF beams. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wen-zhao Sun, Li Chen, Xin Yang, Bin Wang, Xiao-wu Deng, Xiao-yan Huang Tags: Research Paper Source Type: research

The effect of Hsa_circ_0001451 in clear cell renal cell carcinoma cells and its relationship with clinicopathological features
Purpose: Circular RNAs (circRNAs), are a large class of RNAs that from a covalently closed continuous loop and have recently showed huge capabilities as gene regulators in mammals. Although Hsa_circ_0001451 has been investigated in colorectal cancer, it remains unclear about the relationship between Hsa_circ_0001451 and clear cell renal cell carcinoma (ccRCC). Our research aims to reveal the function of Hsa_circ_0001451 in the proliferation and development in ccRCC cells.Methods: The expression of Hsa_circ_0001451 in 52 pairs of ccRCC tissues and paraneoplastic tissues was detected by quantitative real-time polymerase chai...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Gang Wang, Wei Xue, Wengang Jian, Panhong Liu, Zichun Wang, Changlin Wang, Haoming Li, Yipeng Yu, Daming Zhang, Cheng Zhang Tags: Research Paper Source Type: research

The Expression of FAP in Hepatocellular Carcinoma Cells is Induced by Hypoxia and Correlates with Poor Clinical Outcomes
Fibroblast activation protein (FAP) is a serine protease that has been reported in fibroblasts and some carcinoma cells, which correlates with poor patient outcomes. FAP can be induced under hypoxia which is also vital in the malignant behaviors of cancer cells. However, the role of FAP and its correlation with hypoxia has not been investigated in HCC cancer cells. In tissues from post-surgical HCC patients in our center, we adopted immunohistochemistry staining (IHC), western blot and quantitative RT-PCR to detect the expression levels of FAP and the hypoxia related marker, hypoxia inducible factor 1α (HIF-1α)...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Baojia Zou, Xialei Liu, Baimeng Zhang, Yihang Gong, Chaonong Cai, Peiping Li, Jiafan Chen, Shan Xing, Jianxu Chen, Siqi Peng, Bibesh Pokhrel, Lei Ding, Linjuan Zeng, Jian Li Tags: Research Paper Source Type: research

Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection
Conclusion: Surgical treatments are a therapeutic option that can provide more survival benefit for HCC patients with MaVI. With the help of our nomograms, selected HCC patients with MaVI can benefit from hepatic resection and have the same survival rate as that for early-stage HCC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yiquan Jiang, Hui Tang, Zixian Wang, Yuanjing Sun, Wei Meng, Guoying Wang, Hua Li, Shuhong Yi, Genshu Wang, Yang Yang, Guihua Chen Tags: Research Paper Source Type: research

Prognostic value of Systemic immune-inflammation index in cancer: A meta-analysis
Systemic immune-inflammation index (SII), on the basis of lymphocyte, neutrophil and platelet counts had been published to be a good prognostic factor in multiple cancers. Nevertheless, the prognostic value of SII in cancer patients remains inconsistent. Therefore, we carried out a meta-analysis to evaluate the prognostic value of SII in these patients with cancer. A total of 22 articles with 7657 patients enrolled in this meta-analysis. The combined result revealed that a high SII was evidently correlated with poor overall survival (OS) (HR=1.69, 95%CI=1.42-2.01, p
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ruonan Yang, Qian Chang, Xianchun Meng, Nan Gao, Wanhai Wang Tags: Research Paper Source Type: research

Improved Long-Term Clinical Outcomes And Safety Profile Of Sunitinib Dosing Schedule With 4/2 Switched To 2/1 In Patients With Metastatic Renal Cell Carcinoma
Conclusion: Patients with a 4/2-2/1 schedule could minimize treatment-related toxicities; more importantly, patients with 4/2-2/1 schedule could achieve a superior survival benefit. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xingming Zhang, Guangxi Sun, Jinge Zhao, Kunpeng Shu, Peng Zhao, Jiandong Liu, Yaojing Yang, Qidun Tang, Junru Chen, Pengfei Shen, Jia Wang, Hao Zeng Tags: Research Paper Source Type: research

Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma
Conclusions: Lymph node metastases of STS patients selected for ILP seemed to have a negative impact on both overall and disease-free survival. Radical lymph node dissection should be included in ILP procedure. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Fran ç ois Crettenand, David Martin, St é phane Cherix, Nicolas Demartines, Maurice Matter Tags: Research Paper Source Type: research

Impact of body mass index on long-term survival outcome in Asian populations with solid cancer who underwent curative-intent surgery: A six-year multicenter observational cohort study
This study aimed to evaluate the impact of BMI on long-term postoperative survival outcome in a large cohort of Asian population with solid cancers.Methods: A total of 33,551 patients who underwent curative-intent surgery for solid cancers between January 2007 and December 2012 at four hospitals in Taiwan were included. BMI was analyzed using univariate and multivariate regression analyses to determine its association with survival outcome.Results: With a median follow-up of 43.8 (range, 1-91) months, the rate of all-cause mortality was 21.7% (n=7264 patients), while that of cancer-related mortality was 13.4% (n=4499 patie...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chia-Yen Hung, Cheng-Chou Lai, Ping-Tsung Chen, Chang-Hsien Lu, Pei-Hung Chang, Kun-Yun Yeh, Shau-Hsuan Li, Keng-Hao Liu, Yu-Shin Hung, Jen-Shi Chen, Yung-Chang Lin, Wen-Chi Chou Tags: Research Paper Source Type: research

Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer
Translocation associated membrane protein 2 (TRAM2) has been characterized as a component of the translocon that is a gated channel at the endoplasmic reticulum (ER) membrane. TRAM2 is expressed in a wide variety of human organs. To date, no information is available regarding TRAM2 function in the genesis of human cancer. The purpose of this study was to investigate the status of the TRAM2 gene in oral squamous cell carcinoma (OSCC) cells and clinical OSCC samples. Using real-time quantitative reverse transcriptase-polymerase chain reaction, Western blotting analysis, and immunohistochemistry, we detected accelerated TRAM2...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Reo Fukushima, Atsushi Kasamatsu, Dai Nakashima, Morihiro Higo, Kazuaki Fushimi, Hiroki Kasama, Yosuke Endo-Sakamoto, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa Tags: Research Paper Source Type: research

Prognostic Role of MicroRNA-497 In Cancer Patients: A Meta-analysis
Background: MicroRNA-497(miR-497) has been studied for its irreplaceable role of predicting the prognosis of various cancers, but there has been no systematic study to summarize the data. Consequently, we performed this meta-analysis to reveal the association between the expression level of miR-497 and cancer prognosis systematically.Materials and Methods: PubMed was searched for appropriate studies and a total of 12 eligible publications with 989 cancer patients were recruited into our analysis to assess the strength of the association. Hazard ratios (HRs) and odds ratios (ORs) were analyzed to finish this work.Results: T...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jiaxi Feng, Xi Gu, Liyang Liu, Ming Lu, Xiang Ma, Yang Cao, Rongjiang Jiang, Baolin Wang, Qinghong Zhao Tags: Research Paper Source Type: research

Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls
Objectives: The result of the relationship between the MUC1 rs4072037 polymorphism and cancer risk is controversial, we take this meta-analysis to investigate a more precise result.Methods: Electronic database Pubmed, Web of science and Cochrane library had been used to search relevant articles concerning the relationship between MUC1 rs4072037 polymorphism and cancer risk. We used odds ratios (ORs) and 95% confidence intervals (CIs) to assess the strength of the gene-disease association. We also conducted subgroup analysis, sensitivity analyses and publication bias in the meta-analysis.Results: In our meta-analysis, we in...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xi Gu, Jiaxi Feng, Liyang Liu, Ming Lu, Xiang Ma, Yang Cao, Baolin Wang, Qinghong Zhao Tags: Research Paper Source Type: research

Surrogate endpoints shortening the therapeutic evaluation duration for different subgroups of patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy: A retrospective analysis of 830 patients stratified by the 8th edition of the UICC/AJCC staging system and plasma Epstein-Barr viral
Conclusions: The time of therapeutic evaluation could be shortened to
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shu Zhou, Chen Chen, Song-ran Liu, Ya-lan Tao, Hui Chang, Xiao-hui Wang, Xin Yang, Wen-wen Zhang, Shan Liu, Shi-rong Ding, Guan-nan Wang, Yun-fei Xia Tags: Research Paper Source Type: research

Impact of prostatic anterior fat pads with lymph node staging in prostate cancer
Background: Several reports have revealed the presence of lymph nodes in the prostatic anterior fat pad (PAFP). To date, no study has described the characteristics of Taiwanese patients harboring PAFP lymph nodes with metastatic prostate cancer involvement.Method: Between December 2006 and May 2015, a total of 849 consecutive patients underwent robot-assisted laparoscopic radical prostatectomy with PAFP dissection. Pathological examination of the dissected PAFP was conducted to assess the presence of lymphoid tissue and prostate cancer involvement.Results: Of the 849 patients, 76 (9.0%) had 1-3 PAFP lymph nodes. Moreover, ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wei-Chun Weng, Li-Hua Huang, Chao-Yu Hsu, Min-Che Tung, Cheng-Kuang Yang, Jong-Shiaw Jin, Yen-Chuan Ou, Shun-Fa Yang Tags: Research Paper Source Type: research

Dihydroartemisinin enhances VEGFR1 expression through up-regulation of ETS-1 transcription factor
Angiogenesis is required for tumor growth. Dihydroartemisinin (DHA), a the effective anti-malarial derivative of artemisinin, demonstrated potent anti-angiogenic activities that closely related to the regulation of vascular endothelial growth factor (VEGF) signaling cascade. VEGF receptor 1 (VEGFR1), a receptor in endothelial cells (ECs), coordinately regulate angiogenic activity triggered by ligand-receptor binding. Here we aimed to explore the effects of DHA on VEGFR1 expression in ECs. We found that DHA significantly increases VEGFR1 expression in human umbilical vein endothelial cells (HUVECs). In addition, DHA signifi...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Na Niu, Changmei Yu, Liqun Li, Qiang Liu, Wenqian Zhang, Kaili Liang, Youming Zhu, Jing Li, Xia Zhou, Jinbao Tang, Ju Liu Tags: Research Paper Source Type: research

Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?
Hyperactive retrovirus-associated DNA sequence (Ras) genes have been found in human cancers and are involved in cancer pathogenesis. Salirasib, one anti-Ras compound, was reported to exhibit antitumoral effects, but its role remains unclear in cutaneous squamous cell carcinoma (cSCC). In our study, salirasib treatment led to deregulation of c-Raf, ERK and Akt signaling, blockage of MTOR signaling, interruption on Beclin 1-related autophagy regulation, activation of apoptosis and down-regulation of some cell cycle regulatory proteins in primary human epidermal keratinocyte (HEK)s, but did not exhibit similar effects in the ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Li Li, Min Li, Song Xu, Wenbo Bu, Mengli Zhang, Heng Gu, Xu Chen Tags: Short Research Communication Source Type: research

Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function, galactose and fatty acid metabolism
This study suggests that CFG may suppress ovarian cancer cell proliferation and metastasis by regulating mitochondrion-related energy metabolisms. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shanming Ruan, Zhiqian Zhang, Xinxin Tian, Dawei Huang, Wenhong Liu, Bo Yang, Minhe Shen, Fangfang Tao Tags: Research Paper Source Type: research

Antitumor activity of sorafenib plus CDK4/6 inhibitor in pancreatic patient derived cell with KRAS mutation
This study suggests that the combination of RAF and CDK4/6 inhibitors might be a novel treatment strategy for KRAS G12R mutant pancreatic cancer. The antitumor effect of RAF plus CDK4/6 inhibitors also needs to be evaluated in other subtypes of KRAS mutation in pancreatic cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Taehyang Lee, Kyung Kim, Jeeyun Lee, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Joon Oh Park, Seung Tae Kim Tags: Research Paper Source Type: research

High expression of F2RL3 correlates with aggressive features and poor survival in clear cell renal cell carcinoma
Conclusion: These findings suggested that F2RL3 mRNA and protein level in ccRCC is a robust predictor of poorly prognostic phenotype. Exploring the causal relevance of F2RL3 in ccRCC development further warrants in the future study. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Dalong Cao, Yuanyuan Qu, Xuan Zhang, Fujiang Xu, Shuxian Zhou, Guiming Zhang, Bo Dai, Yao Zhu, Guohai Shi, Yijun Shen, Yiping Zhu, Hailiang Zhang, Dingwei Ye, Jianyuan Zhao Tags: Research Paper Source Type: research

Autophagy Inhibition Promotes Bevacizumab-induced Apoptosis and Proliferation Inhibition in Colorectal Cancer Cells
Conclusions: Our results showed that the inhibition of autophagy promoted the anti-tumor effect of bevacizumab and may offer a promising therapeutic strategy for colorectal cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhi Zhao, Guanggai Xia, Ni Li, Ruping Su, Xiao Chen, Li Zhong Tags: Research Paper Source Type: research

The Significance of Liquid Biopsy in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer. The 5-year survival rate for PDAC remains low because it is always diagnosed at an advanced stage and it is resistant to therapy. A biomarker, which could detect asymptomatic premalignant or early malignant tumors and predict the response to treatment, will benefit patients with PDAC. However, traditional biopsy has its limitations. There is an urgent need for a tumor biomarker that could easily and repeatedly sample and monitor, in real time, the progress of tumor development. Liquid biopsy could be a tool to assess potential biomarkers. In...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu Tags: Review Source Type: research

Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis
High c-Met expression has been observed in epithelial ovarian cancer (EOC). However, its clinicopathological impacts remain controversial. We conducted this meta-analysis to evaluate the pathologic and prognostic significance of c-Met overexpression in patients with EOC. A systematic computerized search of the electronic databases PubMed, PMC, EMBASE, and Google scholar (up to April 2018) was carried out. From seven studies, 568 patients with EOC were included in the meta-analysis. Although there was no statistical significance, EOCs with c-Met overexpression tended to show higher FIGO stage (III-IV) (odds ratio = 2.18, 95...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jung Han Kim, Hyun Joo Jang, Hyeong Su Kim, Bum Jun Kim, Sung Ho Park Tags: Research Paper Source Type: research

A miRNA Combination as Promising Biomarker for Hepatocellular Carcinoma Diagnosis: A Study Based on Bioinformatics Analysis
Conclusion: We established a miRNA combination as a promising tool for HCC diagnosis, and the target genes we predicted provide possible points of penetration for researching these two miRNAs in HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jia Ji, Hao Chen, Xiao-Ping Liu, Yu-Hui Wang, Chang-Liang Luo, Wu-Wen Zhang, Wen Xie, Fu-Bing Wang Tags: Research Paper Source Type: research

Weekly versus triweekly cisplatin plus intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma: A propensity score analysis with a large cohort
Conclusion: IMRT concurrent with a weekly cisplatin regimen was associated with significantly improved distant metastasis-free survival in locally advanced NPC. Differences in the selected acute toxicities between the weekly and triweekly concurrent cisplatin regimens were noted. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qian Zhu, Hao Hu, Lin-Quan Tang, Rui You, Jing-Jing Zhao, De-Sheng Weng, Qiu-Zhong Pan, Chang-Long Chen, Zi-Qi Zhou, Yan Tang, Jian-Chuan Xia Tags: Research Paper Source Type: research

PI3K/Akt/HIF-1 α signaling pathway mediates HPV-16 oncoprotein-induced expression of EMT-related transcription factors in non-small cell lung cancer cells
Conclusions: PI3K/Akt/HIF-1α may contribute to the progression of HPV-associated NSCLC via mediating the expression of EMT-related transcription factors in NSCLC cells. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jinhua Liu, Bingyu Huang, Zihan Xiu, Zhiyuan Zhou, Jiao Liu, Xiangyong Li, Xudong Tang Tags: Research Paper Source Type: research

The Predictive Value of Albumin-to-Alkaline Phosphatase Ratio for Overall Survival of Hepatocellular Carcinoma Patients Treated with Trans-Catheter Arterial Chemoembolization Therapy
Background: We have previously reported the prognostic value of the albumin-to-alkaline phosphatase ratio (AAPR) for advanced hepatocellular carcinoma (HCC) patients who are not receiving any standard anticancer therapy. However, the prognostic value of the AAPR for HCC patients treated with trans-catheter arterial chemoembolization therapy (TACE) was not investigated.Methods: We retrospectively analysed 372 HCC patients treated with TACE (the training cohort) and applied receiver operating characteristic curves (ROC curves) to identify the best cut-off value for the AAPR in this cohort. Then, univariate analyses by the Ka...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhan-Hong Chen, Xiao-Ping Zhang, Xiu-Rong Cai, Si-Dong Xie, Meng-Meng Liu, Jin-Xiang Lin, Xiao-Kun Ma, Jie Chen, Qu Lin, Min Dong, Xiang-Yuan Wu, Jing-Yun Wen, Rui-Hua Xu Tags: Research Paper Source Type: research

Eukaryotic translation initiation factor 5A-2 involves in doxorubicin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells
Conclusions: Our study strongly proved that combined treatment with GC7 may boost the therapeutic effect of doxorubicin in OSCC by inhibiting the EMT. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Liang Fang, Li Gao, Lei Xie, Guizhou Xiao Tags: Research Paper Source Type: research

Prognostic value of PD-L1 expression in resected lung adenocarcinoma and potential molecular mechanisms
Background: The prognostic role of PD-L1 expression in surgically resected lung adenocarcinoma (ADC) remains controversial. The present study was aimed to clarify the role of PD-L1 expression in predicting prognosis and to investigate its biological function in ADC.Materials and Methods: The association between PD-L1 expression and clinical outcomes in patients with resected ADC was analyzed using immunohistochemistry (IHC) in our cohort (n=104), externally validated by a meta-analysis of 13 published studies. The biological role of PD-L1 in ADC was explored using gene set enrichment analysis (GSEA).Results: Positive PD-L1...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jianli Ma, Decai Chi, Yan Wang, Yubo Yan, Shu Zhao, Hang Liu, Jing Jing, Haihong Pu, Minghui Zhang Tags: Research Paper Source Type: research

Efficacy of surgery and prophylactic cranial irradiation in stage II and III small cell lung cancer
Conclusions: These findings suggest a potential OS benefit of surgery in stages II and IIIA patients, particularly in selected stage IIIA patients who received adjuvant chemo-radiation and PCI. The use of PCI for surgical patients with stage IIIA was associated with improved OS. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Kunpeng Yin, Dandan Song, Hongwei Zhang, Feng Cai, Jun Chen, Jun Dang Tags: Research Paper Source Type: research

A Refined Staging Model for Resectable Pancreatic Ductal Adenocarcinoma Incorporating Examined Lymph Nodes, Location of Tumor and Positive Lymph Nodes Ratio
Background: Nodal status and tumor site are prognostic factors for resectable pancreatic ductal adenocarcinoma (PDAC). Parameters for nodal status are diverse, and the number of examined lymph nodes (eNs) needed for good prognosis are uncertain. We try to modify staging system of resectable PDAC with parameters mentioned above by recursive partitioning analysis.Methods: Patients from the Surveillance, Epidemiology, and End Results (SEER) database were divided into training cohort and internal validation cohort, randomly. PDAC patients from Sun Yat-sen University Cancer Center were regarded as external validation cohort. Th...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yunda Song, Zhenxin Chen, Luohai Chen, Chaobin He, Xin Huang, Fangting Duan, Jun Wang, Xiangming Lao, Shengping Li Tags: Research Paper Source Type: research

Prevalence of and risk factors for presenting initial respiratory symptoms in patients undergoing surgery for lung cancer
Conclusions: Presenting initial respiratory symptoms was the common cause for medical consultation in patients undergoing lung cancer surgery. Patients with lung cancer in larger tumor size or squamous cell carcinoma more likely presented initial and even multiple initial respiratory symptoms. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiang-Lin Hu, Song-Tao Xu, Xiao-Cen Wang, Dong-Ni Hou, Cui-Cui Chen, Yuan-Lin Song, Dong Yang Tags: Research Paper Source Type: research

TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status
Conclusion: Taken together, our results shed light on that TP53 codon 72 polymorphism was significantly associated with the susceptibility to BC in Asians. In addition, positive associations were also revealed between this polymorphism and tumor stage/smoking status in BC cases. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Lei Zhang, Yi Wang, Zhiqiang Qin, Ran Li, Rong Cong, Chengjian Ji, Xianghu Meng, Yamin Wang, Jiadong Xia, Ninghong Song Tags: Research Paper Source Type: research

Gene expression and single nucleotide polymorphism of ATP7B are associated with platinum-based chemotherapy response in non-small cell lung cancer patients
Conclusion: Our findings indicate that ATP7B rs9526814 may contribute to platinum resistance by influencing ATP7B gene expression and can be used as a potential biomarker to predict the sensitivity of platinum-based chemotherapy in NSCLC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yue-Qin Li, Juan Chen, Ji-Ye Yin, Zhao-Qian Liu, Xiang-Ping Li Tags: Research Paper Source Type: research

Prognostic Stratification of Advanced Gastric Signet Ring Cell Carcinoma by Clinicopathological Factors and GALNT14 Genotype
Conclusions: Gastric SRCC could be stratified into different prognostic subgroups by combining clinicopathological factors and GALNT14 genotype. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Tsung-Hsing Chen, Wey-Ran Lin, Chieh Lee, Cheng-Tang Chiu, Jun-Te Hsu, Ta-Sen Yeh, Kwang-Huei Lin, Puo-Hsien Le, Chau-Ting Yeh Tags: Research Paper Source Type: research

Improved survival in ovarian cancer, with widening survival gaps of races and socioeconomic status: a period analysis, 1983-2012
Introduction: Ovarian cancer is the first leading cause of cancer-related deaths among gynecologic malignancies, and the 7th most common female cancer worldwide. However, previous studies on changes in the long-term survival of ovarian cancer were limited.Methods: Our data were extracted from Surveillance, Epidemiology, and End Results (SEER) registries to assess the incidence and relative survival changes of patients with ovarian cancer during 1983-2012. Patients with ovarian cancer were stratified by age, race, and socioeconomic status (SES). Cox regression analysis and Spearman rank correlation analysis were performed b...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jinna Wu, Huanhuan Sun, Lewei Yang, Yun Deng, Yan Yan, Shuncong Wang, Guangwei Yang, Haiqing Ma Tags: Research Paper Source Type: research

The Role of MicroRNAs in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most common cancers, leading to the second cancer-related death in the global. Although the treatment of HCC has greatly improved over the past few decades, the survival rate of patients is still quite low. Thus, it is urgent to explore new therapies, especially seek for more accurate biomarkers for early diagnosis, treatment and prognosis in HCC. MicroRNAs (miRNAs), small noncoding RNAs, are pivotal participants and regulators in the development and progression of HCC. Great progress has been made in the studies of miRNAs in HCC. The key regulatory mechanisms of miRNAs include ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xin Xu, Yuquan Tao, Liang Shan, Rui Chen, Hongyuan Jiang, Zijun Qian, Feng Cai, Lifang Ma, Yongchun Yu Tags: Review Source Type: research

Proposal for a New TNM Stage based on the 7th and 8th American Joint Committee on Cancer pTNM Staging Classification for Gastric Cancer
Conclusions: We demonstrated that some stage modifications in the 8th AJCC pathologic staging were unnecessary. Therefore we established a new staging system, which was superior to the 7th and 8th staging systems. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Miao-Zhen Qiu, Zi-Xian Wang, Yi-Xin Zhou, Da-Jun Yang, Feng-Hua Wang, Rui-Hua Xu Tags: Research Paper Source Type: research

Adrenal incidentaloma: machine learning-based quantitative texture analysis of unenhanced CT can effectively differentiate sPHEO from lipid-poor adrenal adenoma
Conclusions: Machine learning-based quantitative texture analysis of unenhanced CT may be a reliable quantitative method in differentiating sPHEO from LPA when AI is present. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiaoping Yi, Xiao Guan, Chen Chen, Youming Zhang, Zhe Zhang, Minghao Li, Peihua Liu, Anze Yu, Xueying Long, Longfei Liu, Bihong T Chen, Chishing Zee Tags: Research Paper Source Type: research

Systematic Review and Meta-Analysis on the Association between Polymorphisms in Genes of IL-12 Signaling Pathway and Hepatocellular Carcinoma Risk
We performed an updated meta-analysis and systematic review to explore the associations between polymorphisms in genes of IL-12 signaling pathway and hepatocellular carcinoma (HCC) risk. Diverse databases were retrieved to identify entire available studies, and odds ratios (ORs) correspondence with 95% confidence intervals (CIs) were performed to assess their associations. Finally, 6 polymorphisms in five genes of the IL-12 signaling pathway were extracted from 39 case-control studies, 26 publications. We identified that STAT4-rs7574865 polymorphism was significantly associated with an increased risk of HCC in allelic cont...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yao Xiao, Guodong Liu, Liansheng Gong Tags: Research Paper Source Type: research

LncRNA PVT1 promotes malignant progression in squamous cell carcinoma of the head and neck
Long non-coding RNAs (lncRNAs) are potentially critical regulators of cancer malignant behaviours. Aberrant expression and dysfunction of lncRNA PVT1 have been reported in multiple human cancers. However, its role in squamous cell carcinoma of the head and neck (SCCHN) remains largely unknown. Our current study demonstrated that PVT1 expression was increased in SCCHN. High PVT1 expression was positively correlated with SCCHN clinical parameters including T classification, clinical stages and cervical lymph node metastasis. More importantly, high PVT1 expression predicted a poor prognosis in SCCHN patients. Gain-of function...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Changyun Yu, Yunyun Wang, Guo Li, Li She, Diekuo Zhang, Xiyu Chen, Xin Zhang, Zhaobing Qin, Hua Cao, Yong Liu Tags: Research Paper Source Type: research

CX3CL1 involves in breast cancer metastasizing to the spine via the Src/FAK signaling pathway
C-X3-C chemokine ligand 1 (CX3CL1) has been shown to be involved in the development of multiple tumors. Our previous study demonstrated that CX3CL1 may be involved in the process of metastasis of various malignant tumors to the spine, including breast cancer, but the molecular mechanism was still unknown. In the present study, we found that the receptor CX3CR1 was overexpressed in the spinal metastases of breast cancer than in para-tumor tissue. In terms of CX3CL1, it was significantly more expressed in normal spinal cancellous bone than in limbs. However, CX3CR1 was not expressed at a high level in every breast cancer cel...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yun Liang, Lei Yi, Peng Liu, Libo Jiang, Houlei Wang, Annan Hu, Chi Sun, Jian Dong Tags: Research Paper Source Type: research

Outpatient acupuncture effects on patient self-reported symptoms in oncology care: a retrospective analysis
Background: Increased access to complementary therapies such as acupuncture at academic medical centers has created new opportunities for management of cancer and cancer treatment related symptoms.Methods: Patients presenting for acupuncture treatment during calendar year 2016 at an outpatient integrative medicine clinic in a comprehensive cancer center were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 16 symptoms, score 0-10, 10 worst possible) before and after each visit. ESAS subscales analyzed included global (GDS; score 0-90), physical (PHS, 0-60) and psychological distress (PSS, 0-20). ESAS s...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Gabriel Lopez, M Kay Garcia, Wenli Liu, Michael Spano, Susan Underwood, Seyedeh S Dibaj, Yisheng Li, Rocio Moguel, Janet Williams, Eduardo Bruera, Lorenzo Cohen Tags: Research Paper Source Type: research

Inhibition of Phospholipase D1 mRNA Expression Slows Down the Proliferation Rate of Prostate Cancer Cells That Have Transited to Androgen Independence
To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADPC) cell line LNCaP before and after the occurrence of androgen independence prostate cancer (AIPC) transition. In addition, we used the shRNA lentiviral vector to inhibit the PLD1 mRNA expression and observed its effect on LNCaP cell proliferation after AIPC transition by using MTS method. The results showed t...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wu Zhou, Keqing Shi, Lili Ji, Ruihao Wu, Yuehui Chen, Hongxiang Tu, Beibei Zhou, Zhongyong Wang, Meijuan Zhang Tags: Research Paper Source Type: research

Downregulation of Activin A Receptor Type 2A Is Associated with Metastatic Potential and Poor Prognosis of Colon Cancer
Aims: Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. The aim of this study was to examine the expression profiles and biological functions of ACVR2A in colon cancer.Methods: ACVR2A expression was investigated using the GSE39582 database and two validation cohorts. An in vitro study of cell proliferation and migration of human colon cell lines was also performed.Results: In the GSE39582 database (n= 497), expression of ACVR2A mRNA was identified as a prognost...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Changhua Zhuo, Dan Hu, Jing Li, Hui Yu, Xiandong Lin, Ying Chen, Yong Zhuang, Qingguo Li, Xiongwei Zheng, Chunkang Yang Tags: Research Paper Source Type: research

Risk of upgrading from prostate biopsy to radical prostatectomy pathology: Is magnetic resonance imaging-guided biopsy more accurate?
This study compared magnetic resonance imaging-guided biopsy (MRI-GB) and transrectal ultrasound guided biopsy (TRUS-GB) with the final histology of the radical prostatectomy (RP) specimen.Methods: Our subjects were 229 patients with prostate cancer (PCa), proven histopathologically using MRI-GB or TRUS-GB, who underwent RP at our center between December 2015 and December 2016. The main group included 92 patients who underwent MRI-GB and the control group included 137 patients who underwent 12-core TRUS-GB. Histological findings for RP specimens were compared with those from biopsies. We also evaluated predictors of upgrad...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ning Xu, Yu-Peng Wu, Xiao-Dong Li, Min-Yi Lin, Qing-Shui Zheng, Shao-Hao Chen, Jun-Feng Li, Yong Wei, Xue-Yi Xue Tags: Research Paper Source Type: research

Somatic mutations, clinicopathologic characteristics, and survival in patients with untreated breast cancer with bone-only and non-bone sites of first metastasis
Background: Bone is the most common site of metastasis of breast cancer. Biological mechanisms of metastasis to bone may be different from mechanisms of metastasis to non-bone sites, and identification of distinct signaling pathways and somatic mutations may provide insights on biology and rational targets for treatment and prevention of bone metastasis. The aims of this study were to compare and contrast somatic mutations, clinicopathologic characteristics, and survival in breast cancer patients with bone-only versus non-bone sites of first metastasis.Methods: Primary tumor samples were collected before treatment from 389...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Miho Kono, Takeo Fujii, Naoko Matsuda, Kenichi Harano, Huiqin Chen, Chetna Wathoo, Aron Y. Joon, Debu Tripathy, Funda Meric-Bernstam, Naoto T. Ueno Tags: Research Paper Source Type: research

Variants in the 3'-untranslated region of CUL3 is associated with risk of esophageal squamous cell carcinoma
Conclusion: The results emphasize the importance of CUL3 in the development of ESCC and may contribute to the personalized prevention of this cancer in the future. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jin-Long Hu, Xin-Long Hu, Chuang-Xin Lu, Xue-Jiao Chen, Lei Fu, Qian Han, Shun-Dong Cang Tags: Research Paper Source Type: research

miRNA-21 and miRNA-223 expression signature as a predictor for lymph node metastasis, distant metastasis and survival in kidney renal clear cell carcinoma
Conclusion: The two-miRNA signature could assess nodal metastasis, distant metastasis and predict survival of KIRC. As a promising prediction tool, the mechanism of the two miRNAs in KIRC deserves further study. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Li Yu, Li Xiang, Jihua Feng, Bocheng Li, Zhibin Zhou, Ji Li, Yan Lin, Yufeng Lv, Donghua Zou, Zhuoqing Lei, Jianfeng Zhang Tags: Research Paper Source Type: research