Increased Expression of KNSTRN in Lung Adenocarcinoma Predicts Poor Prognosis: A Bioinformatics Analysis Based on TCGA Data
Conclusion: The findings suggested that the increased expression level of KNSTRN was significantly associated with the progression of LUAD and could also serve as a novel prognostic biomarker for patients with LUAD. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Pengbo Deng, Rongrong Zhou, Jinghui Zhang, Liming Cao Tags: Research Paper Source Type: research
Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p
This study demonstrated that hsa_circ_0091581 is upregulated in glioma tissues and cells. The results of the CCK-8, EdU, and transwell assays indicated that hsa_circ_0091581 promotes proliferation, migration, and invasion of glioma cells. The results of the luciferase reporter and RNA immunoprecipitation assays indicated that the mechanism of the effects of hsa_circ_0091581 on glioma cells involves sponging miR-1243-5p to regulate RMI1. The results of the rescue experiments indicated that hsa_circ_0091581 regulates proliferation, migration, and invasion of glioma cells by targeting RMI1 in a miR-1243-5p dependent manner. T...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jin Qian, Yingna Xu, Xing Xu, Zhenyu Tao, Yang Luo, Yichang Xu, Yong Zhang, Chunfa Qian Tags: Research Paper Source Type: research
Oridonin inhibits tumor angiogenesis and induces vessel normalization in experimental colon cancer
Conclusions: These results highlight the potential effect of ORI on anti-angiogenesis and inducing vessel normalization roles of ORI, and probably provide optimum time point for the ORI therapy in conjunction with the chemoradiotherapy or immunotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jing Zhou, Yaocheng Li, Xuejing Shi, Shulan Hao, Fupeng Zhang, Zhi Guo, Yu Gao, Hao Guo, Likun Liu Tags: Research Paper Source Type: research
Identification of an apoptosis-related prognostic gene signature and molecular subtypes of clear cell renal cell carcinoma (ccRCC)
Previously studies have shown that apoptosis-related genes play an essential role in normal cell turnover, maintaining the immune system function, and inducing cell death. However, their prognostic roles in clear cell renal cell carcinoma (ccRCC) have not been thoroughly investigated. In the present study, apoptosis-related genes expression profiles from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) database were used as training dataset and external validation dataset, respectively. According to the systematical analysis of the apoptosis-related gene expression profile, we constructed a ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Weimin Zhong, Fengling Zhang, Chaoqun Huang, Yao Lin, Jiyi Huang Tags: Research Paper Source Type: research
High expression of TREM2 promotes EMT via the PI3K/AKT pathway in gastric cancer: bioinformatics analysis and experimental verification
Conclusions: We identified some important genes associated with the progression of GC via public database analysis, explored and verified the effects of proto-oncogene TREM2 on EMT via the PI3K/AKT pathway. TREM2 may be a novel target in the GC therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Chunmei Li, Xiaoming Hou, Shuqiao Yuan, Yigan Zhang, Wenzhen Yuan, Xiaoguang Liu, Juan Li, Yuping Wang, Quanlin Guan, Yongning Zhou Tags: Research Paper Source Type: research
LncRNA GAS5 inhibits Invasion and Migration of Lung Cancer through influencing EMT process
Conclusions: These findings provide novel evidence that GAS5 can be viewed as an anti-lung cancer agent through affecting EMT pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Lihuan Zhu, Dongsheng Zhou, Tianxing Guo, Wenshu Chen, Yun Ding, Wujing Li, Yangyun Huang, Jianyuan Huang, Xiaojie Pan Tags: Research Paper Source Type: research
A Novel TNM Classification for Colorectal Cancers based on the Metro-ticket Paradigm
Conclusions: The nTNM classification for CRC has better predictive performances and superior accuracy for predicting prognosis compared with the TNM classification. The nTNM classification should therefore be considered in future revisions of the TNM classification. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jun-Peng Pei, Chun-Dong Zhang, Xiang Fu, Yong Ba, Shuai Yue, Zhe-Ming Zhao, Dong-Qiu Dai Tags: Research Paper Source Type: research
The Effect of Multidisciplinary Team Discussion Intervention on the Prognosis of Advanced Colorectal Cancer
Conclusion: Multidisciplinary team discussion intervention accelerated the treatment process and reduced the death risk of patients with advanced colorectal cancer, especially improved the overall survival of stage IV and invasion T4 patients. The clinical characteristics of tumor invasion and tumor stage must be the primary considerations when judging whether patients need to conduct multidisciplinary team discussions. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Huaqi Zhang, Jishang Yu, Zhewei Wei, Wenhui Wu, Changhua Zhang, Yulong He Tags: Research Paper Source Type: research
RNA-binding protein YBX1 promotes cell proliferation and invasiveness of nasopharyngeal carcinoma cells via binding to AURKA mRNA
Conclusions: The current study indicated that YBX1 promotes NPC cell proliferation and invasiveness through enhancing protein synthesis of AURKA. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yuanyuan Ban, Yixin Tan, Xiaoling Li, Xiayu Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Bo Xiang, Mei Yi Tags: Research Paper Source Type: research
The Yunnan national medicine Maytenus compound inhibits the proliferation of hepatocellular carcinoma (HCC) by suppressing the activation of the EGFR-PI3K-AKT signaling pathway
Conclusion: Maytenus compound significantly inhibited the proliferation of HCC cells in vitro and in vivo. The downregulation of the EGFR-PI3K-AKT signaling pathway and subsequent inhibition of cell cycle progression from G1 to S phase is one of the possible mechanisms. Maytenus compound has a high tumor growth inhibition rate and has no obvious organ toxicity, which may make it a potential anti-HCC drug, but the results from this study need to be confirmed by further clinical trials in HCC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wen-Tao Zhao, Liu-Xin Han, Lin Liu, Bao-Zhen Zeng, Yi Zhang, Liu-Fang Zhao, Hong-Yan Hu, Jia-Wei Xia, Yi-Ze Li, Xu-Dong Xiang, Xiao-Lin Lin, Di Lu, Gao-Feng Li Tags: Research Paper Source Type: research
Cytoreductive Surgery may be beneficial for highly selected patients with Metastatic Gastrointestinal Stromal Tumors receiving Regorafenib facing Local Progression: A Case Controlled Study
Conclusions: Cytoreductive surgery might be feasible in highly selected patients with pre-treated GIST who are being treated with regorafenib experiencing LP. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Chun-Nan Yeh, Chia-Hsiang Hu, Shang-Yu Wang, Chiao-En Wu, Jen-Shi Chen, Chun-Yi Tsai, Jun-Te Hsu, Ta-Sen Yeh Tags: Research Paper Source Type: research
The prediction of survival in Gastric Cancer based on a Robust 13-Gene Signature
This study aimed to establish a robust gene signature to predict the prognosis of GC based on multiple datasets. Initially, we downloaded raw data from four independent datasets of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), and performed univariate Cox proportional hazards regression analysis to identify prognostic genes associated with overall survival (OS) from each dataset. Thirteen common genes from four datasets were screened as candidate prognostic signatures. Then, a risk score model was developed based on this 13‑gene signature and validated by four independent datasets and the entire c...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Guoguang Wang, Tian Zhan, Fan Li, Jian Shen, Xiang Gao, Lei Xu, Yuan Li, Jianping Zhang Tags: Research Paper Source Type: research
Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224-3p/PLK1 signaling
Conclusion: Together, our results revealed that circ-ZNF609 elevates glioma growth and metastasis via enforcing PLK1 expression by competitively binding miR-1224-3p, suggesting that circ-ZNF609 might be an underlying therapeutic target for glioma. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Senjie Du, Hongying Li, Fen Lu, Shang Zhang, Jian Tang Tags: Research Paper Source Type: research
Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1 α / TGF- β
The peritoneal implant metastasis is one of the main pathway and main cause for high mortality for gastric cancer metastasis. Researchs show that epithelial-mesenchymal transition (EMT) playing essential role in modulating gastric cancer metastasis, and the expression of hypoxia inducible factor-1α (HIF-1α) can promote EMT in tumor cells. This research aims to explore the influence and mechanism of Dextran Sulfate (DS) affecting EMT of human gastric cancer. In the present study, we found that DS can enter into the cytoplasm and function in it. Inhibition of HIF-1α or DS significantly inhibit the migration an...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yun-ning Huang, Yuan-yi Xu, Qian Ma, Meng-qi Li, Jia-xin Guo, Xiaofei Wang, Xiu Jin, Jing Shang, Long-xing Jiao Tags: Research Paper Source Type: research
CFP is a prognostic biomarker and correlated with immune infiltrates in Gastric Cancer and Lung Cancer
In this study, the expression pattern and prognostic value of CFP in pan-cancer were analyzed via the Oncomine, PrognoScan, GEPIA and Kaplan-Meier plotters. In addition, we used immunohistochemical staining to validate CFP expression in clinical tissue samples. Finally, we evaluated the correlations between CFP and cancer immune infiltrates particularly in stomach adenocarcinoma (STAD) and lung adenocarcinoma (LUAD) by using GEPIA and TIMER databases. The results of database analysis and immunohistochemistry showed that the expression level of CFP in STAD and LUAD was lower than that in normal tissues. Low expression level...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Guoliang Cui, Le Geng, Li Zhu, Zhenyan Lin, Xuan Liu, Zhengyue Miao, Jintao Jiang, Xiaoke Feng, Fei Wei Tags: Research Paper Source Type: research
