Survival Outcomes Based on Axillary Surgery in Ductal Carcinoma < em > In Situ < /em > : A Nationwide Study From the Korean Breast Cancer Society
CONCLUSION: The decision to perform axillary surgery in patients with a final diagnosis of pure DCIS does not affect the prognosis, regardless of the breast surgical method. Furthermore, regardless of the breast surgical method, axillary surgery, including SLNB, should be considered for high-risk patients, such as those with large tumors. This may reduce unnecessary axillary surgery and enhance the patients' quality of life.PMID:38433090 | PMC:PMC10912575 | DOI:10.4048/jbc.2023.0221 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 3, 2024 Category: Cancer & Oncology Authors: Bong Kyun Kim Joohyun Woo Jeeyeon Lee Eunhye Kang Soo Yeon Baek Seokwon Lee Hyouk Jin Lee Jina Lee Woo Young Sun Korean Breast Cancer Society Source Type: research
Omission of Breast Surgery in Predicted Pathologic Complete Response after Neoadjuvant Systemic Therapy: A Multicenter, Single-Arm, Non-inferiority Trial
This study aims to confirm the non-inferiority of the 5-year disease-free survival of patients who omitted breast surgery when predicted to have a pCR based on breast magnetic resonance imaging (MRI) and VAB after NST, compared with patients with a pCR who had undergone breast surgery in previous studies.METHODS: The Omission of breast surgery for PredicTed pCR patients wIth MRI and vacuum-assisted bIopsy in breaST cancer after neoadjuvant systemic therapy (OPTIMIST) trial is a prospective, multicenter, single-arm, non-inferiority study enrolling in 17 tertiary care hospitals in the Republic of Korea. Eligible patients mus...
Source: Journal of Breast Cancer - March 3, 2024 Category: Cancer & Oncology Authors: Ji-Jung Jung Jong-Ho Cheun Soo-Yeon Kim Jiwon Koh Jai Min Ryu Tae-Kyung Yoo Hee-Chul Shin Sung Gwe Ahn Seho Park Woosung Lim Sang-Eun Nam Min Ho Park Ku Sang Kim Taewoo Kang Jeeyeon Lee Hyun Jo Youn Yoo Seok Kim Chang Ik Yoon Hong-Kyu Kim Hyeong-Gon Moon Source Type: research
Survival Outcomes Based on Axillary Surgery in Ductal Carcinoma < em > In Situ < /em > : A Nationwide Study From the Korean Breast Cancer Society
CONCLUSION: The decision to perform axillary surgery in patients with a final diagnosis of pure DCIS does not affect the prognosis, regardless of the breast surgical method. Furthermore, regardless of the breast surgical method, axillary surgery, including SLNB, should be considered for high-risk patients, such as those with large tumors. This may reduce unnecessary axillary surgery and enhance the patients' quality of life.PMID:38433090 | PMC:PMC10912575 | DOI:10.4048/jbc.2023.0221 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 3, 2024 Category: Cancer & Oncology Authors: Bong Kyun Kim Joohyun Woo Jeeyeon Lee Eunhye Kang Soo Yeon Baek Seokwon Lee Hyouk Jin Lee Jina Lee Woo Young Sun Korean Breast Cancer Society Source Type: research
Omission of Breast Surgery in Predicted Pathologic Complete Response after Neoadjuvant Systemic Therapy: A Multicenter, Single-Arm, Non-inferiority Trial
This study aims to confirm the non-inferiority of the 5-year disease-free survival of patients who omitted breast surgery when predicted to have a pCR based on breast magnetic resonance imaging (MRI) and VAB after NST, compared with patients with a pCR who had undergone breast surgery in previous studies.METHODS: The Omission of breast surgery for PredicTed pCR patients wIth MRI and vacuum-assisted bIopsy in breaST cancer after neoadjuvant systemic therapy (OPTIMIST) trial is a prospective, multicenter, single-arm, non-inferiority study enrolling in 17 tertiary care hospitals in the Republic of Korea. Eligible patients mus...
Source: Journal of Breast Cancer - March 3, 2024 Category: Cancer & Oncology Authors: Ji-Jung Jung Jong-Ho Cheun Soo-Yeon Kim Jiwon Koh Jai Min Ryu Tae-Kyung Yoo Hee-Chul Shin Sung Gwe Ahn Seho Park Woosung Lim Sang-Eun Nam Min Ho Park Ku Sang Kim Taewoo Kang Jeeyeon Lee Hyun Jo Youn Yoo Seok Kim Chang Ik Yoon Hong-Kyu Kim Hyeong-Gon Moon Source Type: research
Survival Outcomes Based on Axillary Surgery in Ductal Carcinoma < em > In Situ < /em > : A Nationwide Study From the Korean Breast Cancer Society
CONCLUSION: The decision to perform axillary surgery in patients with a final diagnosis of pure DCIS does not affect the prognosis, regardless of the breast surgical method. Furthermore, regardless of the breast surgical method, axillary surgery, including SLNB, should be considered for high-risk patients, such as those with large tumors. This may reduce unnecessary axillary surgery and enhance the patients' quality of life.PMID:38433090 | DOI:10.4048/jbc.2023.0221 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 3, 2024 Category: Cancer & Oncology Authors: Bong Kyun Kim Joohyun Woo Jeeyeon Lee Eunhye Kang Soo Yeon Baek Seokwon Lee Hyouk Jin Lee Jina Lee Woo Young Sun Korean Breast Cancer Society Source Type: research
Omission of Breast Surgery in Predicted Pathologic Complete Response after Neoadjuvant Systemic Therapy: A Multicenter, Single-Arm, Non-inferiority Trial
This study aims to confirm the non-inferiority of the 5-year disease-free survival of patients who omitted breast surgery when predicted to have a pCR based on breast magnetic resonance imaging (MRI) and VAB after NST, compared with patients with a pCR who had undergone breast surgery in previous studies.METHODS: The Omission of breast surgery for PredicTed pCR patients wIth MRI and vacuum-assisted bIopsy in breaST cancer after neoadjuvant systemic therapy (OPTIMIST) trial is a prospective, multicenter, single-arm, non-inferiority study enrolling in 17 tertiary care hospitals in the Republic of Korea. Eligible patients mus...
Source: Journal of Breast Cancer - March 3, 2024 Category: Cancer & Oncology Authors: Ji-Jung Jung Jong-Ho Cheun Soo-Yeon Kim Jiwon Koh Jai Min Ryu Tae-Kyung Yoo Hee-Chul Shin Sung Gwe Ahn Seho Park Woosung Lim Sang-Eun Nam Min Ho Park Ku Sang Kim Taewoo Kang Jeeyeon Lee Hyun Jo Youn Yoo Seok Kim Chang Ik Yoon Hong-Kyu Kim Hyeong-Gon Moon Source Type: research
Oncologic Outcomes of Immediate Breast Reconstruction in the Setting of Neoadjuvant Chemotherapy: A Long-term Follow-up Study of a Matched Cohort
CONCLUSION: Our findings suggest that IBR following SSM/NSM elicits comparable long-term oncologic outcomes to those of TM alone in the setting of NACT.PMID:38233336 | DOI:10.4048/jbc.2023.0196 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Dong Seung Shin Yoon Ju Bang Joon Young Choi Sung Yoon Jang Hyunjun Lee Youngji Kwak Byung Joo Chae Jonghan Yu Jeong Eon Lee Seok Won Kim Seok Jin Nam Byung-Joon Jeon Jai Kyong Pyon Goo-Hyun Mun Kyeong-Tae Lee Jai Min Ryu Source Type: research
Potential Perturbations of Critical Cancer-regulatory Genes in Triple-Negative Breast Cancer Cells Within the Humanized Microenvironment of Patient-derived Xenograft Models
CONCLUSION: Humanized PDX models successfully recreated tumor-immune interactions in TNBC. TNFRSF11B, a commonly downregulated gene in humanized PDX models, may play a key role in tumor growth and metastasis. Differential tumor growth rates and gene expression patterns highlighted the complexities of the immune response in the tumor microenvironment of humanized PDX models.PMID:38233337 | DOI:10.4048/jbc.2023.0177 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Yujeong Her Jihui Yun Hye-Youn Son Woohang Heo Jong-Il Kim Hyeong-Gon Moon Source Type: research
Racial/Ethnic Differences in Pathologic Complete Response to Neoadjuvant Chemotherapy and Survival Among Early-Stage, Erb-B2 Receptor Tyrosine Kinase 2-Low Breast Cancer Patients
J Breast Cancer. 2024 Feb;27(1):54-60. doi: 10.4048/jbc.2023.0166. Epub 2024 Jan 18.ABSTRACTRacial/ethnic differences in pathologic complete response (pCR), and in overall survival (OS) by pCR status, among early-stage, erb-b2 receptor tyrosine kinase 2 (ERBB2)-low breast cancer patients after neoadjuvant chemotherapy (NACT) are unknown. Data were from the 2010-2020 National Cancer Database that included Asian/Pacific Islander (API), American Indian/Alaska Native/Other (AIANO), Black, Hispanic, and White patients. pCR and OS were modeled using logistic regression and Cox regression, respectively. Of 25,577 patients, Black ...
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Jincong Q Freeman James L Li Olasubomi J Omoleye Source Type: research
A Rare Case of Erdheim Chester's Disease Presenting As Atypical Breast Involvement
J Breast Cancer. 2024 Jan 18. doi: 10.4048/jbc.2023.0111. Online ahead of print.ABSTRACTErdheim-Chester disease (ECD) is a rare multisystem disorder characterized by mitogen-activated protein kinase (MAPK) pathway mutations. Herein, we present a unique case of ECD in a 79-year-old female with predominant breast nodules. Comprehensive imaging and histopathological evaluations confirmed the diagnosis. Mammography and ultrasonography revealed multiple hyperdense circumscribed nodules with coalescing masses and blurred margins. Core biopsy revealed infiltrating foamy CD68+ and CD1a+ histiocytes. Because the tumor was negative ...
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Flavia Sprenger Alana Gomes Pecorari Valmir Vicente Filho Sofia Tokars Kluppel Ana Carolina Staats Source Type: research
Oncologic Outcomes of Immediate Breast Reconstruction in the Setting of Neoadjuvant Chemotherapy: A Long-term Follow-up Study of a Matched Cohort
CONCLUSION: Our findings suggest that IBR following SSM/NSM elicits comparable long-term oncologic outcomes to those of TM alone in the setting of NACT.PMID:38233336 | DOI:10.4048/jbc.2023.0196 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Dong Seung Shin Yoon Ju Bang Joon Young Choi Sung Yoon Jang Hyunjun Lee Youngji Kwak Byung Joo Chae Jonghan Yu Jeong Eon Lee Seok Won Kim Seok Jin Nam Byung-Joon Jeon Jai Kyong Pyon Goo-Hyun Mun Kyeong-Tae Lee Jai Min Ryu Source Type: research
Potential Perturbations of Critical Cancer-regulatory Genes in Triple-Negative Breast Cancer Cells Within the Humanized Microenvironment of Patient-derived Xenograft Models
CONCLUSION: Humanized PDX models successfully recreated tumor-immune interactions in TNBC. TNFRSF11B, a commonly downregulated gene in humanized PDX models, may play a key role in tumor growth and metastasis. Differential tumor growth rates and gene expression patterns highlighted the complexities of the immune response in the tumor microenvironment of humanized PDX models.PMID:38233337 | DOI:10.4048/jbc.2023.0177 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Yujeong Her Jihui Yun Hye-Youn Son Woohang Heo Jong-Il Kim Hyeong-Gon Moon Source Type: research
Evaluation of Racial/Ethnic Differences in Pathologic Complete Response to Neoadjuvant Chemotherapy and Survival Among Early-Stage, Erb-B2 Receptor Tyrosine Kinase 2-Low Breast Cancer Patients
J Breast Cancer. 2024 Jan 18. doi: 10.4048/jbc.2023.0166. Online ahead of print.ABSTRACTRacial/ethnic differences in pathologic complete response (pCR), and in overall survival (OS) by pCR status, among early-stage, erb-b2 receptor tyrosine kinase 2 (ERBB2)-low breast cancer patients after neoadjuvant chemotherapy (NACT) are unknown. Data were from the 2010-2020 National Cancer Database that included Asian/Pacific Islander (API), American Indian/Alaska Native/Other (AIANO), Black, Hispanic, and White patients. pCR and OS were modeled using logistic regression and Cox regression, respectively. Of 25,577 patients, Black pati...
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Jincong Q Freeman James Li Olasubomi Omoleye Source Type: research
A Rare Case of Erdheim Chester's Disease Presenting As Atypical Breast Involvement
J Breast Cancer. 2024 Jan 18. doi: 10.4048/jbc.2023.0111. Online ahead of print.ABSTRACTErdheim-Chester disease (ECD) is a rare multisystem disorder characterized by mitogen-activated protein kinase (MAPK) pathway mutations. Herein, we present a unique case of ECD in a 79-year-old female with predominant breast nodules. Comprehensive imaging and histopathological evaluations confirmed the diagnosis. Mammography and ultrasonography revealed multiple hyperdense circumscribed nodules with coalescing masses and blurred margins. Core biopsy revealed infiltrating foamy CD68+ and CD1a+ histiocytes. Because the tumor was negative ...
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Flavia Sprenger Alana Gomes Pecorari Valmir Vicente Filho Sofia Tokars Kluppel Ana Carolina Staats Source Type: research
Oncologic Outcomes of Immediate Breast Reconstruction in the Setting of Neoadjuvant Chemotherapy: A Long-term Follow-up Study of a Matched Cohort
CONCLUSION: Our findings suggest that IBR following SSM/NSM elicits comparable long-term oncologic outcomes to those of TM alone in the setting of NACT.PMID:38233336 | DOI:10.4048/jbc.2023.0196 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - January 17, 2024 Category: Cancer & Oncology Authors: Dong Seung Shin Yoon Ju Bang Joon Young Choi Sung Yoon Jang Hyunjun Lee Youngji Kwak Byung Joo Chae Jonghan Yu Jeong Eon Lee Seok Won Kim Seok Jin Nam Byung-Joon Jeon Jai Kyong Pyon Goo-Hyun Mun Kyeong-Tae Lee Jai Min Ryu Source Type: research
