Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not. Additionally...
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Satomi Shiba Michiko Harao Akira Saito Masako Sakuragi Joji Kitayama Naohiro Sata Source Type: research
Hypofractionated Partial Breast Irradiation With Intensity-Modulated Radiotherapy in Early Breast Cancer or Carcinoma < em > In Situ < /em > : An Investigational Short-Term Analysis
CONCLUSION: Hypofractionated PBI demonstrated favorable IBTR rates in patients with early breast cancer, with low incidence of acute and late toxicities in the short-term analysis.PMID:38529590 | DOI:10.4048/jbc.2023.0296 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Nam Kyu Kang Soo-Yoon Sung Sung Hwan Kim Ye Won Jeon Young Jin Suh Jong Hoon Lee Source Type: research
Five-Fraction High-Conformal Ultrahypofractionated Radiotherapy for Primary Tumors in Metastatic Breast Cancer
CONCLUSION: In our small dataset, 5-fraction, high-conformal ultrahypofractionated breast RT offered promising 2-year local control with minimal toxicity. Further studies are warranted to investigate the optimal dose and role in this setting.PMID:38529591 | DOI:10.4048/jbc.2024.0004 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Jeongshim Lee Jee Hung Kim Mitchell Liu Andrew Bang Robert Olson Jee Suk Chang Source Type: research
Correlation of Neutrophil-Lymphocyte and Albumin-Globulin Ratios With Outcomes in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy or Upfront Surgery
CONCLUSION: NLR and AGR are useful in predicting the response to NACT as well as prognosis of patients with breast cancer. Further studies are needed to explore their value in clinical decision making.PMID:38529588 | DOI:10.4048/jbc.2023.0242 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Shi Hui Yang Min Li Tey Siqin Zhou Phyu Nitar Hanis Mariyah Yirong Sim Grace Kusumawidjaja Wen Yee Chay Wong Fuh Yong Ru Xin Wong Source Type: research
Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not. Additionally...
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Satomi Shiba Michiko Harao Akira Saito Masako Sakuragi Joji Kitayama Naohiro Sata Source Type: research
Hypofractionated Partial Breast Irradiation With Intensity-Modulated Radiotherapy in Early Breast Cancer or Carcinoma < em > In Situ < /em > : An Investigational Short-Term Analysis
CONCLUSION: Hypofractionated PBI demonstrated favorable IBTR rates in patients with early breast cancer, with low incidence of acute and late toxicities in the short-term analysis.PMID:38529590 | DOI:10.4048/jbc.2023.0296 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Nam Kyu Kang Soo-Yoon Sung Sung Hwan Kim Ye Won Jeon Young Jin Suh Jong Hoon Lee Source Type: research
Five-Fraction High-Conformal Ultrahypofractionated Radiotherapy for Primary Tumors in Metastatic Breast Cancer
CONCLUSION: In our small dataset, 5-fraction, high-conformal ultrahypofractionated breast RT offered promising 2-year local control with minimal toxicity. Further studies are warranted to investigate the optimal dose and role in this setting.PMID:38529591 | DOI:10.4048/jbc.2024.0004 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Jeongshim Lee Jee Hung Kim Mitchell Liu Andrew Bang Robert Olson Jee Suk Chang Source Type: research
Correlation of Neutrophil-Lymphocyte and Albumin-Globulin Ratios With Outcomes in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy or Upfront Surgery
CONCLUSION: NLR and AGR are useful in predicting the response to NACT as well as prognosis of patients with breast cancer. Further studies are needed to explore their value in clinical decision making.PMID:38529588 | DOI:10.4048/jbc.2023.0242 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Shi Hui Yang Min Li Tey Siqin Zhou Phyu Nitar Hanis Mariyah Yirong Sim Grace Kusumawidjaja Wen Yee Chay Wong Fuh Yong Ru Xin Wong Source Type: research
Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not. Additionally...
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Satomi Shiba Michiko Harao Akira Saito Masako Sakuragi Joji Kitayama Naohiro Sata Source Type: research
Hypofractionated Partial Breast Irradiation With Intensity-Modulated Radiotherapy in Early Breast Cancer or Carcinoma < em > In Situ < /em > : An Investigational Short-Term Analysis
CONCLUSION: Hypofractionated PBI demonstrated favorable IBTR rates in patients with early breast cancer, with low incidence of acute and late toxicities in the short-term analysis.PMID:38529590 | DOI:10.4048/jbc.2023.0296 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Nam Kyu Kang Soo-Yoon Sung Sung Hwan Kim Ye Won Jeon Young Jin Suh Jong Hoon Lee Source Type: research
Five-Fraction High-Conformal Ultrahypofractionated Radiotherapy for Primary Tumors in Metastatic Breast Cancer
CONCLUSION: In our small dataset, 5-fraction, high-conformal ultrahypofractionated breast RT offered promising 2-year local control with minimal toxicity. Further studies are warranted to investigate the optimal dose and role in this setting.PMID:38529591 | DOI:10.4048/jbc.2024.0004 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Jeongshim Lee Jee Hung Kim Mitchell Liu Andrew Bang Robert Olson Jee Suk Chang Source Type: research
Correlation of Neutrophil-Lymphocyte and Albumin-Globulin Ratios With Outcomes in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy or Upfront Surgery
CONCLUSION: NLR and AGR are useful in predicting the response to NACT as well as prognosis of patients with breast cancer. Further studies are needed to explore their value in clinical decision making.PMID:38529588 | DOI:10.4048/jbc.2023.0242 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Shi Hui Yang Min Li Tey Siqin Zhou Phyu Nitar Hanis Mariyah Yirong Sim Grace Kusumawidjaja Wen Yee Chay Wong Fuh Yong Ru Xin Wong Source Type: research
Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus
This study investigated the clinical effect of metformin on breast cancer patients with preexisting type 2 diabetes mellitus (T2DM). We analyzed 177 patients with T2DM who underwent breast cancer surgery and assessed tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in patients who underwent tumor resection with or without metformin treatment using multiplex immunohistochemistry (IHC). Patients who received metformin either pre- or postoperatively exhibited reduced distant organ recurrence and improved postoperative recurrence-free survival compared to those of patients who did not. Additionally...
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Satomi Shiba Michiko Harao Akira Saito Masako Sakuragi Joji Kitayama Naohiro Sata Source Type: research
Hypofractionated Partial Breast Irradiation With Intensity-Modulated Radiotherapy in Early Breast Cancer or Carcinoma < em > In Situ < /em > : An Investigational Short-Term Analysis
CONCLUSION: Hypofractionated PBI demonstrated favorable IBTR rates in patients with early breast cancer, with low incidence of acute and late toxicities in the short-term analysis.PMID:38529590 | DOI:10.4048/jbc.2023.0296 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Nam Kyu Kang Soo-Yoon Sung Sung Hwan Kim Ye Won Jeon Young Jin Suh Jong Hoon Lee Source Type: research
Five-Fraction High-Conformal Ultrahypofractionated Radiotherapy for Primary Tumors in Metastatic Breast Cancer
CONCLUSION: In our small dataset, 5-fraction, high-conformal ultrahypofractionated breast RT offered promising 2-year local control with minimal toxicity. Further studies are warranted to investigate the optimal dose and role in this setting.PMID:38529591 | DOI:10.4048/jbc.2024.0004 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - March 26, 2024 Category: Cancer & Oncology Authors: Jeongshim Lee Jee Hung Kim Mitchell Liu Andrew Bang Robert Olson Jee Suk Chang Source Type: research
