Clonality analysis and IDH1 and IDH2 mutation detection in both components of dedifferentiated chondrosarcoma, implicated its monoclonal origin
Publication date: Available online 4 May 2020Source: Journal of Bone OncologyAuthor(s): Tingting Yang, Yueqing Bai, Jie Chen, Keyang Sun, Yanli Luo, Wentao Huang, Huizhen Zhang (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - May 6, 2020 Category: Cancer & Oncology Source Type: research

Commentary to “Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis of randomized trials » (Galvano et al. J Bone Oncol 2019; 18:100252)
Publication date: Available online 28 April 2020Source: Journal of Bone OncologyAuthor(s): Elena Gonzalez-Rodriguez, Bérengère Aubry-Rozier, Delphine Stoll, Khalil Zaman, Olivier Lamy (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 28, 2020 Category: Cancer & Oncology Source Type: research

Reply to: Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis of randomized trials (Galvano et al., J Bone Oncol 2019; 18:100252)
Publication date: Available online 28 April 2020Source: Journal of Bone OncologyAuthor(s): Antonio Galvano, Dalila Scaturro, Viviana Bazan, Letizia Mauro Giulia, Antonio Russo (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 28, 2020 Category: Cancer & Oncology Source Type: research

Influence of chemotherapy and endocrine treatment on fractures in postmenopausal women with breast cancer – a retrospective cohort study
Publication date: Available online 24 April 2020Source: Journal of Bone OncologyAuthor(s): Ulla Stumpf, Karel Kostev, Georg Siebenbürger, Wolfgang Böcker, Peyman Hadji (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 24, 2020 Category: Cancer & Oncology Source Type: research

Local surgical complication rates in patients receiving surgery without immediate post-operative radiation therapy for lower extremity bone metastases
Publication date: Available online 23 April 2020Source: Journal of Bone OncologyAuthor(s): William Pidduck, Leah Drost, Albert Yee, Edward Chow, Ravi Tuazon, Patrick Henry (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 24, 2020 Category: Cancer & Oncology Source Type: research

The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair
Publication date: Available online 19 April 2020Source: Journal of Bone OncologyAuthor(s): Liang Xu, Zhengkao Sun, Xianfu Wei, Hongdong Tan, Peng Kong, Zhenfeng Li, Qiang Yang, E'nuo Dai, Jianmin Li (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 21, 2020 Category: Cancer & Oncology Source Type: research

High-Grade Surface Osteosarcoma: Clinical Features and Oncologic Outcome
Publication date: Available online 18 April 2020Source: Journal of Bone OncologyAuthor(s): Zhiping Deng, Zhen Huang, Yi Ding, Yongbin Su, Chung Ming Chan, Xiaohui Niu (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 19, 2020 Category: Cancer & Oncology Source Type: research

Adapting palliative radiation therapy for bone metastases during the Covid-19 pandemic: GEMO position paper
Publication date: Available online 13 April 2020Source: Journal of Bone OncologyAuthor(s): Sébastien Thureau, Jean Christophe Faivre, Richard Assaker, Emmanuel Biver, Cyrille B. Confavreux, Françoise Debiais, Martine Duterque-Coquillaud, Fransesco Giammarile, Dominique Heymann, Frédéric E. Lecouvet, Laetitia Morardet, Frederic Paycha, Jean-Jacques Body, Marie-Hélène Vieillard (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 13, 2020 Category: Cancer & Oncology Source Type: research

Response from authors (Sorensen et al.)
Publication date: June 2020Source: Journal of Bone Oncology, Volume 22Author(s): Michala Skovlund Sørensen (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 4, 2020 Category: Cancer & Oncology Source Type: research

Response from authors (Sorensen et al)
Publication date: Available online 19 March 2020Source: Journal of Bone OncologyAuthor(s): Michala Skovlund Sørensen (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - March 21, 2020 Category: Cancer & Oncology Source Type: research

Corrigendum to: ``The immune landscape of chondrosarcoma reveals an immunosuppressive environment in the dedifferentiated subtypes and exposes CSFR1+ macrophages as a promising therapeutic target.'' J Bone Oncol. 2020 Feb; 20: 100271
Publication date: Available online 16 March 2020Source: Journal of Bone OncologyAuthor(s): Iseulys Richert, Anne Gomez-Brouchet, Corinne Bouvier, Gonzague Du Bouexic De Pinieux, arie KaranianM, Jean-Yves Blay, Aurélie Dutour (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - March 18, 2020 Category: Cancer & Oncology Source Type: research

Heterogeneity of chondrosarcomas response to irradiations with X-rays and carbon ions: a comparative study on five cell lines
Publication date: Available online 28 February 2020Source: Journal of Bone OncologyAuthor(s): Nicolas Girard, Eva Lhuissier, Juliette Aury-Landas, Olivier Cauvard, Marion Lente, Martine Boittin, Catherine Baugé, Karim Boumediene (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - February 29, 2020 Category: Cancer & Oncology Source Type: research

Retraction notice
Publication date: Available online 21 February 2020Source: Journal of Bone OncologyAuthor(s): Shenglong Li, Peng Chen, Qian kun Yang (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - February 22, 2020 Category: Cancer & Oncology Source Type: research

The immune landscape of chondrosarcoma - potential for therapeutic targeting of CSFR1+ macrophages
Publication date: February 2020Source: Journal of Bone Oncology, Volume 20Author(s): Iseulys Richert, Anne Gomez-Brouchet, Corinne Bouvier, Gonzague Du Bouexic De Pinieux, Marie Karanian, Jean-Yves Blay, Aurélie DutourAbstractSurvival rate for Chondrosarcoma (CHS) is at a standstill, more effective treatments are urgently needed. Consequently, a better understanding of CHS biology and its immune environment is crucial to identify new prognostic factors and therapeutic targets.Here, we exhaustively describe the immune landscape of conventional and dedifferentiated CHS. Using IHC and molecular analyses (RT-qPCR), we m...
Source: Journal of Bone Oncology - February 19, 2020 Category: Cancer & Oncology Source Type: research

Bone metastases in thyroid cancer
Publication date: Available online 19 February 2020Source: Journal of Bone OncologyAuthor(s): Nicole M. Iñiguez-Ariza, Keith C. Bible, Bart L. ClarkeAbstractWhereas preemptive screening for the presence of lymph node and lung metastases is standard-of-care in thyroid cancer patients, bone metastases are less well studied and are often neglected in thyroid cancer patient surveillance. Bone metastases in thyroid cancer are, however, independently associated with poor/worse prognosis with a median overall survival from detection of only 4 years despite an otherwise excellent prognosis for the vast majority of thyroid c...
Source: Journal of Bone Oncology - February 19, 2020 Category: Cancer & Oncology Source Type: research

Long noncoding RNA OR3A4 promotes the proliferation and invasion of osteosarcoma cells by sponging miR-1227-5p
Publication date: April 2020Source: Journal of Bone Oncology, Volume 21Author(s): Changcheng Yang, Xingrui Cai, Mengsi Yu, Bangmin Wang, Song Wang, Zhihui He, Jiangzheng Zeng, Boke Zhang, Yanda LuAbstractBackgroundLong noncoding RNAs (lncRNAs) have been identified as key players in promoting tumourigenesis in osteosarcoma. LncRNA OR3A4 (OR3A4) has been reported as an oncogene in a number of tumours. However, the clinical value of OR3A4 in osteosarcoma and the role of OR3A4 in osteosarcoma progression are still unknown.MethodsThe expression levels of OR3A4 in the tumour tissue of osteosarcoma patients and osteosarcoma cell ...
Source: Journal of Bone Oncology - February 15, 2020 Category: Cancer & Oncology Source Type: research

Prognostic factors in osteosarcoma: A study level meta-analysis and systematic review of current practice
Publication date: Available online 12 February 2020Source: Journal of Bone OncologyAuthor(s): Sun Xin, Guo WeiAbstractBackgroundA consensus has not yet been reached regarding the abilities of gender, age, tumor size, tumor location, histologic subtypes, and surgery in the prediction of survival in osteosarcoma. We aimed to disclose their prognostic significance by conducting a meta-analysis of all the published data from the last decade.Materials and MethodsElectronic database searches were conducted in PubMed, Embase, and Web of Science for relevant articles published within the last ten years. The pooled hazard ratio (HR...
Source: Journal of Bone Oncology - February 13, 2020 Category: Cancer & Oncology Source Type: research

Use of endoprostheses for proximal femur metastases results in a rapid rehabilitation and low risk of implant failure. A prospective population- based study- Letter to the Editor
Publication date: Available online 5 February 2020Source: Journal of Bone OncologyAuthor(s): Akshat Gupta, Abhay Elhence (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - February 7, 2020 Category: Cancer & Oncology Source Type: research

Exosomes derived from bone marrow mesenchymal stem cells promote osteosarcoma development by activating oncogenic autophagy
Publication date: Available online 4 February 2020Source: Journal of Bone OncologyAuthor(s): Yao Huang, Wei Liu, Bing He, Lei Wang, Fucheng Zhang, Hao Shu, Luning SunAbstractOsteosarcoma (OS) is a malignant bone tumor that frequently occurs in adolescents. It has a high rate of pulmonary metastasis and mortality. Previous studies have demonstrated that human bone marrow mesenchymal stem cells (hBMSCs) can promote the malignant progression in various tumors, including OS. Also, it is recognized that exosomes derived from hBMSCs (hBMSC-Exos) mediate cell-to-cell communication and exhibit similar effects on the development of...
Source: Journal of Bone Oncology - February 6, 2020 Category: Cancer & Oncology Source Type: research

Long Noncoding RNA OR3A4 Promotes Proliferation and Invasion of Osteosarcoma Cells through sponging miR-1227-5p
Publication date: Available online 1 February 2020Source: Journal of Bone OncologyAuthor(s): Changcheng Yang, Xingrui Cai, Mengsi Yu, Bangmin Wang, Song Wang, Zhihui He, Jiangzheng Zeng, Boke Zhang, Yanda LuAbstractBackground: Long noncoding RNAs (lncRNAs) have been identified as a key player in promoting tumorigenesis of osteosarcoma. LncRNA OR3A4 has been reported as an oncogene in a number of tumors. However, the clinical value of lncRNA OR3A4 in osteosarcoma and the role of OR3A4 in osteosarcoma progression are still unknown.Methods: The expression levels of OR3A4 in the tumor tissue of osteosarcoma patients and osteos...
Source: Journal of Bone Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Rapid detection of EGFR mutations in decalcified lung cancer bone metastasis
Publication date: Available online 10 January 2020Source: Journal of Bone OncologyAuthor(s): Antoine Boureille, Carole Ferraro-Peyret, Guillaume Pontarollo, Cyrille Confavreux, Jean-Baptiste Pialat, Sylvie Isaac, Fabien Forest, Violaine Yvorel, Emanuel Watkin, Nicolas Girard, Marie BrevetABSTRACTDetection of molecular alterations in lung cancer bone metastasis (LCBM) is particularly difficult when decalcification procedure is needed. The Idylla™ real-time (RT)-PCR is compared to the routine method used in our laboratory, which combines next generation and Sanger sequencing, for the detection of EGFR mutations in LCBM...
Source: Journal of Bone Oncology - January 12, 2020 Category: Cancer & Oncology Source Type: research

Total vertebral involvement by benign fibrous histiocytoma: A case report and literature review
ConclusionsTo our knowledge, this is the first case of total vertebral BFH. Spinal BFH is a considered a non-aggressive benign lesion. Surgical intervention is usually sufficient for managing BFH with both recurrence and metastasis uncommon. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - January 12, 2020 Category: Cancer & Oncology Source Type: research

Bone decalcification to assess programmed cell death ligand 1 expression in bone metastases of non-small cell lung cancers
Publication date: Available online 8 January 2020Source: Journal of Bone OncologyAuthor(s): Guillaume Pontarollo, Cyrille B. Confavreux, Jean-Baptiste Pialat, Sylvie Isaac, Fabien Forest, Violaine Yvorel, Jean-Michel Maury, Nicolas Girard, Marie BrevetAbstractAs for molecular alterations of lung adenocarcinoma, it is critical that pathologists are able to give PD-L1 expression status before first-line of treatment. The present study compared PD-L1 expression (clone 22-C3) in decalcified using EDTA or formic acid and non-decalcified lung cancer metastases bone samples. Among the 84 bone samples analysed for PD-L1 expression...
Source: Journal of Bone Oncology - January 9, 2020 Category: Cancer & Oncology Source Type: research

The immune landscape of chondrosarcoma reveals an immunosuppressive environment in the dedifferentiated subtypes and exposes CSFR1+ macrophages as a promising therapeutic target
Publication date: February 2020Source: Journal of Bone Oncology, Volume 20Author(s): Richert Iseulys, Gomez-Brouchet Anne, Bouvier Corinne, Du Bouexic De Pinieux Gonzague, Karanian Marie, Blay Jean-Yves, Dutour AurélieAbstractSurvival rate for Chondrosarcoma (CHS) is at a standstill, more effective treatments are urgently needed. Consequently, a better understanding of CHS biology and its immune environment is crucial to identify new prognostic factors and therapeutic targets.Here, we exhaustively describe the immune landscape of conventional and dedifferentiated CHS. Using IHC and molecular analyses (RT-qPCR), we m...
Source: Journal of Bone Oncology - December 25, 2019 Category: Cancer & Oncology Source Type: research

The First Total Vertebral Involvement of Benign Fibrous Histiocytoma: A Case Report and Literature Review
ConclusionsThis is the first total vertebral BFH up to now. Spinal BFH occupies rather low aggressiveness. With rather limited recurrence and malignant degeneration, surgical interventions seem enough for its management. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 22, 2019 Category: Cancer & Oncology Source Type: research

Patterns of care for patients with metastatic bone disease in solid tumors: A cross-sectional study from Switzerland (SAKK 95/16)
ConclusionsThis cross-sectional, non-interventional study, found high implementation of guideline-recommended BTA prescribing, good pain control and low incidence of skeletal related events. Long-term BTA randomized controlled trials have the potential to further optimize routine care outcomes for patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 16, 2019 Category: Cancer & Oncology Source Type: research

Analgesia from percutaneous thermal ablation plus cementoplasty for cancer bone metastases
ConclusionsOur systematic review suggested that thermal ablation combined with cementoplasty could be a safe and effective intervention for the management of bone metastases-induced pain. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 10, 2019 Category: Cancer & Oncology Source Type: research

Primary desmoplastic small round cell tumor of the tibia: PET/CT and MRI presentation of a rare case and review of the literature
In this study, we reported a new case of primary DSRCT of the tibia in a 33-year-old man who had intermittent pain in the left tibia. Radiographs showed transparent lesions in the left upper tibial. MRI revealed a lobular, lytic and ill-identified lesion with adjacent soft tissues swelling of the upper left tibia. CT confirmed notable destruction and wormlike osteolysis of the bone cortex. PET/CT showed a mass of high uptakes, indicating the malignance. He accepted surgical resection with followed multi-agent chemotherapy, containing vincristine, doxorubicin, ifosfamide and etoposide. Clinically and radiologically, the pat...
Source: Journal of Bone Oncology - December 4, 2019 Category: Cancer & Oncology Source Type: research

Functional variant of IL33 is associated with survival of osteosarcoma patients
Publication date: Available online 2 December 2019Source: Journal of Bone OncologyAuthor(s): Qingxi Lin, Jingjing Han, Qi Sun, Li Wen, Shoufeng WangAbstractObjectives: Previous genome-wide association study showed that GLDC/IL33 loci were associated with overall survival in patients with osteosarcoma (OS). We performed a replication study to explore whether variants of GLDC/IL33 are associated with the survival of OS patients and to further verify their functional role in the gene expression.Methods: A total of 216 patients with OS were enrolled. The overall survival time was calculated from the date of diagnosis till the ...
Source: Journal of Bone Oncology - December 3, 2019 Category: Cancer & Oncology Source Type: research

The immune landscape of chondrosarcoma reveals an immunosuppressive environment and exposes macrophages as a promising therapeutic target
Publication date: Available online 26 November 2019Source: Journal of Bone OncologyAuthor(s): Richert Iseulys, Gomez-Brouchet Anne, Bouvier Corinne, Du Bouexic De Pinieux Gonzague, Karanian Marie, Blay Jean-Yves, Dutour AurélieAbstractSurvival rate for Chondrosarcoma (CHS) is at a standstill, more effective treatments are urgently needed. Consequently, a better understanding of CHS biology and its immune environment is crucial to identify new prognostic factors and therapeutic targets.Here, we exhaustively describe the immune landscape of conventional and dedifferentiated CHS. Using IHC and molecular analyses (RT-qP...
Source: Journal of Bone Oncology - November 27, 2019 Category: Cancer & Oncology Source Type: research

Evaluating the Scope of Intramedullary invasion of Malignant Bone Tumor by DCE-MRI Quantitative Parameters in Animal study
ConclusionQuantitative parameters Ktrans, Kep and ve can assess the extent of intramedullary invasion of malignant bone tumors. Ktrans have highest accuracy in differentiating different regions. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - November 20, 2019 Category: Cancer & Oncology Source Type: research

A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival
In this study we aimed at identifying kinase inhibitors that inhibit the survival of chondrosarcoma cells and thereby serve as new potential therapeutic strategies to treat chondrosarcoma patients.An siRNA screen targeting 779 different kinases was conducted in JJ012 chondrosarcoma cells in parallel with a compound screen consisting of 273 kinase inhibitors in JJ012, SW1353 and CH2879 chondrosarcoma cell lines. AURKA, CHK1 and PLK1 were identified as most promising targets and validated further in a more comprehensive panel of chondrosarcoma cell lines. Dose response curves were performed using tyrosine kinase inhibitors: ...
Source: Journal of Bone Oncology - November 18, 2019 Category: Cancer & Oncology Source Type: research

Clinical outcome for small cell lung cancer patients with bone metastases at the time of diagnosis
ConclusionThis study includes preliminary clinical data of SCLC patients with bone metastases at the time of diagnosis, and more studies are needed. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - November 14, 2019 Category: Cancer & Oncology Source Type: research

Analgesia of Percutaneous Thermal Ablation Plus Cementoplasty for Cancer Bone Metastases
Conclusions: Our systematic review suggested that thermal ablation combined with cementoplasty could be a safe and effective intervention for the management of bone metastases-induced pain. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - November 5, 2019 Category: Cancer & Oncology Source Type: research

Clinical outcome for small cell lung cancer patients with bone metastases at the time of diagnosis: a simple scoring system predicting survival
ConclusionThis study demonstrates preliminary clinical data of SCLC with bone metastases at the time of diagnosis, and more studies are needed. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - November 3, 2019 Category: Cancer & Oncology Source Type: research

Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature
Publication date: Available online 31 October 2019Source: Journal of Bone OncologyAuthor(s): Alexander Klein, Felix Tauscher, Christof Birkenmaier, Andrea Baur-Melnyk, Thomas Knösel, Volkmar Jansson, Hans Roland DürrAbstractIntroduction: Clear cell chondrosarcoma (CCC) is a rare subtype of chondrosarcoma and it is commonly considered a low-grade tumor and less aggressive than atypical cartilaginous tumor (grade 1 central chondrosarcoma). However, the experience even of musculoskeletal tumor centres with this rare entity is limited. The aim of this study is to analyse our own treatment results and those of the lit...
Source: Journal of Bone Oncology - November 1, 2019 Category: Cancer & Oncology Source Type: research

Use of endoprostheses for proximal femur metastases results in a rapid rehabilitation and low risk of implant failure. A prospective population-based study
ConclusionsEndoprosthesis for treatment of MBDf results in low implant failure. Patients are satisfied with the functional outcome. QoL is restored six-weeks after surgery. Authors advocate for caution using internal fixation for MBDf due to findings of possible early postoperative revision risk. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - October 23, 2019 Category: Cancer & Oncology Source Type: research

Radiomics signature extracted from diffusion-weighted magnetic resonance imaging predicts outcomes in osteosarcoma
This study tested the hypothesis that a radiomic signature extracted from Diffusion-weighted magnetic resonance images (DWI-MRI) can improve prediction of overall survival (OS) compared with clinical factors alone in localised osteosarcoma.Materials/MethodsPre-treatment DWI-MRI were collected from 112 patients (9-67 years of age) with histological-proven osteosarcoma that were treated with curative intent. The entire dataset was divided in two subsets: the training and validation cohorts containing 76 and 24% of the data respectively. Clinical data were extracted from our medical record. Two experienced radiotherapist...
Source: Journal of Bone Oncology - October 5, 2019 Category: Cancer & Oncology Source Type: research

Diagnostic accuracy of functional imaging modalities for chondrosarcoma: A systematic review and meta-analysis
ConclusionsLow-grade chondrosarcomas continue to pose a diagnostic dilemma. FDG-PET demonstrated superior diagnostic accuracy compared to Tc-99m MDP, Thallium-201 and Tc-99m DMSA (V). Characteristic uptake patterns of Thallium-201 and Tc-99m DMSA (V) may provide additional metabolic information to guide the diagnosis in this challenging group of tumours. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - September 26, 2019 Category: Cancer & Oncology Source Type: research

An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain
Publication date: Available online 18 September 2019Source: Journal of Bone OncologyAuthor(s): Sarah Danson, Matthew R Mulvey, Lesley Turner, Janet Horsman, K Jane Escott, Robert E Coleman, Sam H Ahmedzai, Michael I Bennett, David AndrewAbstractPain is a major symptom of bone metastases from advanced cancer and represents a clinical challenge to treat effectively. Basic neurobiology in preclinical animal models implicates enhanced sensory processing in the central nervous system, acting through N-methyl-D-aspartate (NMDA) glutamate receptors, as an important mechanism underpinning persistent pain. The non-receptor tyrosine...
Source: Journal of Bone Oncology - September 19, 2019 Category: Cancer & Oncology Source Type: research

The bone metastasis niche in breast cancer: potential overlap with the haematopoietic stem cell niche in vivo
Conclusion: Our data provide evidence that homing of breast cancer cells is independent of their ER status and that the breast cancer bone metastasis niche is located within the trabecular region of bone, an area rich in osteoblasts and microvessels. The increased number of breast cancer cells homing to bone after mobilisation of HSCs suggests that the HSC and the bone metastasis niche overlap. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - September 13, 2019 Category: Cancer & Oncology Source Type: research

Survival and prognosis in malignant giant cell tumor of bone: a population-based analysis from 1984 to 2013
This study aimed to determine the impact of demographics, tumor characteristics, and treatment on prognosis among patients with MGCTB.MethodsThe Surveillance, Epidemiology, and End Results database was used to identify patients with MGCTB from 1984 to 2013. Kaplan-Meier analyses were performed to determine the overall survival (OS). Univariable and multivariable Cox analyses were conducted to identify prognostic factors.ResultsThere were 250 patients with MGCTB included in our study. The multivariate Cox analysis revealed that age at diagnosis (hazard ratio [HR]: 1.09; 95% confidence interval [CI]: 1.07-1.11; P
Source: Journal of Bone Oncology - September 11, 2019 Category: Cancer & Oncology Source Type: research

Atypical femoral fractures from bisphosphonate in cancer patients – Review
Publication date: Available online 22 August 2019Source: Journal of Bone OncologyAuthor(s): Matthew Lockwood, Rajesh Banderudrappagari, Larry J. Suva, Issam MakhoulAbstractBisphosphonates are commonly used in patients with metastatic bone disease to prevent skeletal related events. Atypical femur fracture is a known complication of long-term bisphosphonate use but the incidence in cancer patients and pathogenesis are not well known. Several mechanisms of pathogenesis have been proposed including altered angiogenesis, altered bone mechanical properties, micro damage and bone remodeling suppression. Atypical femur fractures ...
Source: Journal of Bone Oncology - August 24, 2019 Category: Cancer & Oncology Source Type: research

Histological, epidemiological and anatomical analysis of 193 bone tumours of the scapula
ConclusionsEvaluation of 193 bone tumours of the scapula revealed a high incidence of malignancy in this series, while increased patient age was identified as a potential risk factor for the development of a malignant lesion of the scapula. These findings highlight the importance of early diagnosis and treatment of suspicious lesions of the scapula to improve patient outcome. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 24, 2019 Category: Cancer & Oncology Source Type: research

Intra-articular osteoid osteoma accompanied by extensive bone marrow edema. A clinical and micro-morphological analysis
In this study, a consecutive series of four patients suffering from extensive bone marrow edema triggered by intra-articular osteoid osteoma underwent clinical examination, magnetic resonance imaging (MRI) and computed tomography (CT) as well as dual-energy X-ray absorptiometry (DXA) and laboratory bone turnover analyses. The obtained resection specimens were processed by undecalcified histology and were subsequently analyzed by light microscopy and quantitative backscattered electron imaging (qBEI). We report an entity of intra-articular osteoid osteoma in the knee and foot, in which an extensive and persistent bone marro...
Source: Journal of Bone Oncology - August 21, 2019 Category: Cancer & Oncology Source Type: research

Mouse Model Recapitulates the Phenotypic Heterogeneity of Human Adult T-cell Leukemia/Lymphoma in Bone
Publication date: Available online 20 August 2019Source: Journal of Bone OncologyAuthor(s): Nicole A. Kohart, Said M. Elshafae, Wachirapan Supsahvad, Aylin Alasonyalilar-Demirer, Amanda R. Panfil, Jingyu Xiang, Wessel P. Dirksen, Deborah J. Veis, Patrick L. Green, Katherine N. Weilbaecher, Thomas J. RosolAbstractAdult T-cell leukemia/lymphoma has a unique relationship to bone including latency in the marrow, and development of bone invasion, osteolytic tumors and humoral hypercalcemia of malignancy. To study these conditions, we established and characterized a novel mouse model of ATL bone metastasis. Patient-derived ATL c...
Source: Journal of Bone Oncology - August 21, 2019 Category: Cancer & Oncology Source Type: research

Denosumab for bone health in prostate and breast cancer patients receiving endocrine therapy? A systematic review and a meta-analysis of randomized trials
In conclusion, Denosumab administration can be considered effective and safe in the prevention and management of the above mentioned adverse events related to hormonal therapies designed for breast and prostate tumors. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 9, 2019 Category: Cancer & Oncology Source Type: research

Chondroblastoma in pelvis and extremities- a signle centre study of 177 cases
ConclusionsChondroblastoma is a rare benign to intermediate grade bone tumour with a potential to metastasise. Femoral head chondroblastoma is rare, presenting 4.5% of all chondroblastoma cases. Around 50% of the chondroblastoma in femoral head. occur in patients with open growth plates. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 6, 2019 Category: Cancer & Oncology Source Type: research

Aneurysmal bone cyst: a review of 65 patients
ConclusionCurettage is still the standard of treatment for ABC. Local recurrence does not depend on the use of adjuvant phenol as shown in this and other studies. Minimally invasive methods such as selective embolization and injections of sclerosing agents may result in healing or at least in tolerable persistence of residual lesions but needs repetitive treatments and does not show homogenous results throughout the institutions. Denosumab appears to be an additional option, especially in surgically critical locations such as the spine or the sacrum. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 6, 2019 Category: Cancer & Oncology Source Type: research

Incidence of fractures in young women with breast cancer - a retrospective cohort study
Publication date: Available online 26 July 2019Source: Journal of Bone OncologyAuthor(s): Ulla Stumpf, Karel Kostev, Jannis Kyvernitakis, Wolfgang Böcker, Peyman HadjiAbstractIn recent years, cancer treatment-induced bone loss (CTIBL) and increased risk of fracture has become an emerging problem as breast cancer (BC) survival has increased due to early diagnosis and improved treatments. In premenopausal women with BC, chemotherapy and tamoxifen are the treatments of choice in hormone receptor-negative and hormone receptor-positive BC respectively. Their effect on fracture risk has only been investigated in a few small...
Source: Journal of Bone Oncology - July 26, 2019 Category: Cancer & Oncology Source Type: research