Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma.
CONCLUSIONS: The findings suggested a therapeutic potential of berberine on OVA- induced airway inflammation. The ameliorative effects on the OVA-induced airway inflammation might be associated with the inhibition of the NF-κB signaling pathway. PMID: 27175622 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 17, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

A Regional Cohort Study of the Treatment of Critically Ill Children with Bronchiolitis.
CONCLUSIONS: Even within a close geographic region, there is significant variation in the treatment provided to critically ill children with RSV bronchiolitis. None of these treatments were associated with shorter durations of hospitalization in this population and some, such as mechanical ventilation, were associated with longer ICU lengths of stay. PMID: 27177013 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 17, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Transferability of genome-wide associated loci for asthma in African Americans.
CONCLUSIONS: This study has successfully transferred four reported asthma-associated loci in an independent African American population. Identification of several asthma-associated SNPs in the upstream of the IL33, a gene previously implicated in allergic inflammation of asthmatic airway, supports the generalizability of this finding. PMID: 27177148 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 17, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Is The Mars Questionnaire A Reliable Measure Of Medication Adherence In Childhood Asthma?
Authors: Garcia-Marcos PW, Brand PL, Kaptein AA, Klok T Abstract OBJECTIVE: To assess the reliability of the Medication Adherence Report Scale (MARS-5) for assessing adherence in clinical practice and research. METHODS: Prospective cohort study following electronically measured inhaled corticosteroids (ICS) adherence for 1 year in 2-13 year old children with persistent asthma. The relationship between electronically measured adherence and MARS-5 scores (ranging from 5 to 25) was assessed by Spearman's rank correlation coefficient. A ROC (receiver operating characteristic) curve was performed testing M...
Source: Journal of Asthma - May 17, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

San Francisco childcare centers' preparedness in the prevention and management of asthma among preschool-aged children.
Authors: Young CA, Stookey J, Patel AI, Chan C, Evans J, Cohn K, Agana L, Yen IH, Fernandez A, Cabana MD Abstract INTRODUCTION: Asthma is a common health condition for children in childcare. National recommendations for asthma in childcare exist. However, no studies have investigated the extent to which childcare centers adhere to these recommendations. We aimed to assess childcare center adherence to National Asthma Education and Prevention Program (NAEPP) recommendations for asthma care and preparedness and to identify characteristics associated with increased adherence to national asthma recommendations. MET...
Source: Journal of Asthma - May 12, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

How can Adherence to Asthma Medication be Enhanced? Triangulation of Key Asthma Stakeholders' Perspectives.
CONCLUSION: Asthma medication adherence is a complex process and successful interventions aimed at improving it would benefit from: (a) making an effort to understand patients' experiences and negotiate the treatment regimen, rather than imposing recommendations; (b) considering treatment as a shared responsibility involving the patient, the healthcare professional(s), and the patients' social networks; PMID: 27167629 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 12, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Optimizing screening for depression among adults with asthma.
CONCLUSIONS: Results suggest that the BDI-II is an appropriate screening tool for MDD in asthma populations. However, the cut-off score is influenced by the sociodemographic and clinical characteristics of patients. These findings highlight the importance of validating generic questionnaires for depression in specific populations in order to improve the accuracy of their usage. PMID: 27159640 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 11, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Frequency of health service use in the year prior to asthma death.
CONCLUSIONS: Frequency of HSU in the year prior was substantially higher in those died from asthma. Specifically, more than one asthma hospital admission, three ED visits or five physician visits increased the asthma mortality risk substantially and exponentially. PMID: 27153342 [PubMed - in process] (Source: Journal of Asthma)
Source: Journal of Asthma - May 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Atopy, but Not Obesity is Associated with Asthma Severity Among Children with Persistent Asthma.
CONCLUSION: Atopy may be a more important risk factor for asthma severity than obesity among low-income minority children and adolescents with persistent asthma living in Northeastern cities in the United States. PMID: 27144330 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Primary tracheal papilloma disguised as asthma: a case report.
Conclusion Primary tracheal papilloma is mimicker of asthma, CT scan should be considered in patients with persistent chronic cough, or stridor. Endoscopic papillectomy is a safe and effective treatment and should be considered as first-line therapy for tracheal papilloma. PMID: 27144426 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Omalizumab treatment in asthma-COPD overlap syndrome.
Conclusion Our study shows that omalizumab may be an effective and safe therapy for patients with ACOS. However larger randomized trials are needed. PMID: 27144514 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

The difference in amount of physical activity performed by children with and without asthma: A systematic review and meta-analysis.
CONCLUSION: We did not find any evidence that children and adolescents with and without asthma engaged in different amounts of physical activity when measured objectively by accelerometers. Children and adolescents with asthma may not require differentially targeted policies to encourage more physical activity, however further longitudinal studies are needed. PMID: 27144654 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

The development of an educational video to motivate teens with asthma to be more involved during medical visits and to improve medication adherence.
CONCLUSIONS: Teens, parents, and providers gave us excellent insight into developing videos to increase teen involvement during medical visits. PMID: 27145093 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Reduced clot retraction rate and altered platelet energy production in patients with asthma.
Authors: Tomasiak-Lozowska MM, Rusak T, Misztal T, Bodzenta-Lukaszyk A, Tomasiak M Abstract OBJECTIVE: Asthma enhances the risk of pulmonary embolism. The mechanism of this phenomenon is unclear. METHODS: We evaluated the kinetics of clot formation, clot retraction rate (CRR), clot volume at 40 min, the rate of lactate production (a marker of aerobic glycolysis in platelets in contracting clots), blood eosinophil count (EOS), nitric oxide in exhaled breath (FENO), and spirometry (FEV1) in 50 healthy controls and in 81 allergic asthmatics (41 subjects with steroid-naïve asthma and 40 with steroid-treat...
Source: Journal of Asthma - May 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Chlamydia pneumoniae, and mycoplasma pneumoniae: Are they related to severe asthma in childhood?
Authors: Iramain R, De Jesús R, Spitters C, Jara A, Jimenez J, Bogado N, Cardozo L Abstract BACKGROUND: Mycoplasma pneumoniae and Chlamydia pneumoniae are frequent agents of acute respiratory diseases and they have been recognized as infectious triggers of asthma. OBJECTIVE: To determine the frequency of these triggers and their relationship to severe asthma. METHODS: 82 patients were enrolled in a prospective cross-sectional study from January 2007 to March 2013 and they were divided into three study groups: Group 1: 27 children with severe asthma, Group 2: 29 children with stable asthma and Group 3...
Source: Journal of Asthma - April 29, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

The Integrated Care of Asthma in Switzerland (INCAS)-study: Patients' perspective of received asthma care and their interest in asthma education.
Authors: Dürr S, Hersberger KE, Zeller A, Scheuzger J, Miedinger D, Gregoriano C, Leuppi JD, Steurer-Stey C Abstract OBJECTIVE: For successful long-term asthma care, self-management education is a cornerstone. Little is known about associations between patients' interest in education, asthma control and care delivery. We compared patients' characteristics, asthma control and patients' perspective about asthma care in subjects with and without interest in asthma education. Moreover, we assessed reasons, why patients denied participating in asthma education. METHODS: Baseline data of 223 patients with asthma...
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Development of a patient decision aid on inhaled corticosteroids use for adults with asthma.
CONCLUSION: Our newly developed PDA was found acceptable and usable in target users. PMID: 27115196 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Asthma, COPD and comorbidities in elderly people.
CONCLUSION: Asthma coexisted frequently with arterial hypertension and depression in elderly patients. Patients with COPD have a more exaggerated profile of coexisting diseases, specifically cardiovascular problems. PMID: 27115313 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

CT-assessed large airway involvement and lung function decline in eosinophilic asthma: The association between induced sputum eosinophil differential counts and airway remodeling.
CONCLUSIONS: The findings indicate that induced sputum eosinophil differential counts may be associated with airway remodeling in patients with stable asthma. PMID: 27115448 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Acculturation and Quality of Life in Urban, African American Caregivers of Children with Asthma.
CONCLUSIONS: Less acculturation tied to religious beliefs/practices and family values (as measured by the AAAS-R) may serve a protective role in reducing the burden low-income, urban African American caregivers experience in managing child asthma. This study is the first of its kind to study acculturation in African American caregivers of children with asthma. PMID: 27115558 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Outcomes of Follow-Up Care After an Emergency Department Visit Among Pediatric Asthmatics in the Military Health System.
CONCLUSIONS: Despite universal access to healthcare, less than half of pediatric MHS asthma patients had follow-up within 28 days of an ED visit. Those with follow-up were more likely to fill a controller medication within 90 days post ED visit, and less likely to have an asthma ED re-visit in the subsequent year. PMID: 27115719 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Asthma-specific health related quality of life of people in Great Britain: A national survey.
CONCLUSIONS: This paper provides benchmarking data on asthma-specific HRQOL. Improved strategies are needed to target interventions towards people experiencing poor HRQOL. PMID: 27115826 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Pediatric acute asthma exacerbations: evaluation and management from emergency department to intensive care unit.
CONCLUSIONS: Asthma is the most common chronic disease of childhood, and acute exacerbations are a significant burden to patients and to public health. Optimal assessment and management of exacerbations, including appropriate escalation of interventions, are essential to minimize morbidity and prevent mortality. While inhaled albuterol and systemic corticosteroids are the mainstay of exacerbation management, escalation may include interventions discussed in this review. PMID: 27116362 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Adolescent, caregiver, and friend preferences for integrating social support and communication features into an asthma self-management app.
CONCLUSIONS: Given preferences expressed in this study, apps may help adolescents obtain social support to better self-manage their asthma. Future app-based interventions should include features enabling adolescents with asthma to communicate and interact with their caregivers, medical providers, and friends. PMID: 27116540 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Cost of severe asthma in Brazil - Systematic review.
Conclusion Hospitalizations and medications seem to be the most important resources funded by the Brazilian public health system and by patients and their families. Although further studies are necessary, as information on cost of this disease is scarce in Brazil, these findings suggest that there is a potential room for improving severe asthma care among Brazilian patients. PMID: 27116649 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 27, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

What lies beyond Asthma Control Test: suggestions for clinical practice.
Authors: Caminati M, Caimmi C, Dama A, Schiappoli M, Passalacqua G, Senna G Abstract BACKGROUND: Asthma Control Test (ACT ™) validity relies on Global Initiative for Asthma (GINA) definition of control. It includes neither reversibility nor inflammation assessment despite their importance as hallmark of asthma, partially unrelated to symptoms. Furthermore though rhinitis may affect the patient's perception of asthma control, its impact on ACT accuracy has not been systematically evaluated. OBJECTIVE: To explore ACT validity according to a definition of control including: forced expiratory volume in 1 s (F...
Source: Journal of Asthma - April 24, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Toxocariasis and childhood asthma: a case-control study.
The objective of this study is to investigate the association between anti-Toxocara IgG seropositivity and asthma in children. METHODS: This was a case-control study conducted in a university hospital in south Brazil between May 2012 and June 2013. Were recruited 208 children up to 12 years old of whom 156 had asthma (cases) and 52 did not have asthma (controls), with a case-control ratio of 3:1 matched by age. Children's parents or guardians were interviewed using a structured questionnaire with closed questions. Serology was performed using enzyme-linked immunosorbent assay (ELISA) with excretory-secretory antig...
Source: Journal of Asthma - April 24, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Comparison of serum biomarkers between patients with asthma and with chronic obstructive pulmonary disease.
This study compared the profiles of serum biomarkers between patients with asthma and those with COPD. METHODS: Serum levels of the chitinase like protein YKL-40, periostin, interleukin (IL)-18, and chemokine (C--C motif) ligand 18 (CCL18) were measured in asthma patients (n = 20), COPD patients (n = 16), and normal controls (n = 20). RESULTS: Serum levels of YKL-40 were higher in COPD patients [median (range), 55 (17-565) versus 208 (74-922) ng/mL, p
Source: Journal of Asthma - April 24, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Manual external chest compression in severe pediatric asthma.
Authors: Brooks R, Eisenstein EM PMID: 27104780 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 24, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Asthma in Asia: Physician perspectives on control, inhaler use and patient communications.
CONCLUSION: Physicians and patients have different views of 'well-controlled' asthma. While physicians informed patients about asthma and inhaler usage, they overestimated actual usage and patients' knowledge was sub-optimal. Physician-patient interactions can be augmented with understanding of patient attitudes, visual aids and ancillary support to perform physical demonstrations to improve treatment outcomes. PMID: 27096388 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 21, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Feasibility of a worksheet for facilitating self-management in children with asthma.
Authors: Shomaker KL, DeVeau-Rosen SH Abstract BACKGROUND: Few tools exist to facilitate recommended self-management support for children with asthma. We sought to examine the feasibility, acceptance and preliminary results of a novel worksheet designed to provide such support for children and their caregivers presenting for asthma care. METHODS: A 12-topic asthma worksheet was modeled on currently available self-management tools and based on the behavior change theory and motivational interviewing techniques. Children 1-18 years old with asthma and their caregivers were recruited from an allergy clinic and an ...
Source: Journal of Asthma - April 21, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Genetic risk of TNFSF4 and FAM167A-BLK polymorphisms in children with asthma and allergic rhinitis in a Han Chinese population.
CONCLUSION: This study supports that the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and AR gene risk in the Han Chinese cohort. PMID: 27088737 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 20, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Vitamin D Receptor Polymorphisms May Contribute to Asthma Risk.
CONCLUSIONS: This meta-analysis provides convincing evidence that rs2228570, rs7975232, rs731236 and rs3782905 gene polymorphisms in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphisms could be developed as biomarkers for asthma susceptibility. PMID: 27088875 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 20, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Occurrence and impact of sinusitis in patients with asthma and/or allergic rhinitis.
CONCLUSIONS: Occurrence of radiological sinusitis on CT-PNS in asthmatics without nasal symptoms and CRS in allergic rhinitis with or without asthma increases the severity of the disease and affects the QoL. PMID: 27064727 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 12, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Enabling and hindering factors influencing adherence to asthma treatment among adolescents: a systematic literature review.
Conclusion Working with this particular age group is complex and further research in understanding adolescent's behavior, motives, beliefs and perceptions towards adherence to asthma treatment is required to guide them towards better self-management and acceptance of their condition. PMID: 27053332 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 9, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Inspiratory muscle function in asthmatic and healthy subjects: influence of age, nutrition and physical activity.
CONCLUSIONS: Results demonstrate a reduction in the IME in asthmatic adolescents with overweight and obesity, indicating an association between asthma, nutritional status and respiratory muscle function. PMID: 27057823 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 9, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Asthma susceptibility variants are more strongly associated with clinically similar subgroups.
This study evaluated whether GWAS-nominated SNPs are more strongly associated with asthma patients sharing the same clinical characteristics in order to refine the role of recently identified genes. METHODS: Analyses were performed in unrelated French Canadian subjects (566 cases and 416 controls) with data collected on lung function, blood cell counts, atopy, disease history and medication. Previously defined asthma subgroups were used for analysis: 1) older patients with low atopy and low lung function, 2) high atopy, 3) young non-smoking women and 4) high smoking history. Allele frequencies of 68 GWAS-nominated SNPs...
Source: Journal of Asthma - April 9, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Factors affecting ability to achieve asthma control in adult patients with moderate to severe persistent asthma.
FACTORS AFFECTING ABILITY TO ACHIEVE ASTHMA CONTROL IN ADULT PATIENTS WITH MODERATE TO SEVERE PERSISTENT ASTHMA. J Asthma. 2016 Apr 8;:1-26 Authors: Scott L, Li M, Thobani S, Nichols B, Morphew T, Kwong KY Abstract OBJECTIVE: Despite the use of optimal therapy and guidelines, the rate of asthma control is suboptimal in adult populations. Purpose of this study is to describe factors associated with ability to achieve well-controlled asthma over time for adult patients treated in a tertiary medical center-based asthma outpatient specialty clinic Methods: Existing clinical data collected for 320 adult pat...
Source: Journal of Asthma - April 9, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Association between thromboxane A2 receptor polymorphisms and asthma risk: a meta-analysis.
CONCLUSION: Our results suggested that TBXA2R +924C/T polymorphism is associated with asthma risk, and +795C/T polymorphism may be a risk factor for AIA. Larger-scale and well-designed studies are required to validate the association identified in the current meta-analysis. PMID: 27058349 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 9, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Adapting and implementing an evidence-based asthma counseling intervention for resource-poor populations.
Authors: Thornton E, Kennedy S, Hayes-Watson C, Krouse RZ, Mitchell H, Cohn RD, Wildfire J, Mvula MM, Lichtveld M, Grimsley F, Martin WJ, Stephens KU Abstract OBJECTIVE: To report implementation strategies and outcomes of an evidence-based asthma counseling intervention. The Head-off Environmental Asthma in Louisiana (HEAL) intervention integrated asthma counseling (AC) capacity and addressed challenges facing children with asthma in post-disaster New Orleans. METHODS: The HEAL intervention enrolled 182 children (4-12 years) with moderate-to-severe persistent asthma. Recruitment occurred from schools in th...
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Effective allergen avoidance for reducing exposure to house mite allergens and improving disease management in adult atopic asthmatics.
Authors: Tsurikisawa N, Saito A, Oshikata C, Yasueda H, Akiyama K Abstract OBJECTIVE: We investigated the best strategy for adult asthmatics to avoid exposure to Dermatophagoides group (Der-1) allergens. METHODS: Adult atopic asthmatics (n = 111) followed a 32-item checklist for avoiding Der-1 allergen exposure. Twenty-five patients were excluded through incomplete sampling; 50 remaining patients encased their pillows/futons/mattresses in microfine-fiber covers, 13 used vacuum cleaners with dust-mite-collection nozzles, and 23 acted as non-intervention controls. During August-October 2010 and August-October 201...
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Development, feasibility, and validity of a computer-based utility assessment tool for measuring asthma-specific health utilities in Malaysia using the standard gamble method.
Authors: Yong YV, Shafie AA PMID: 27049693 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Agreement between current and active asthma classification methods, Asthma Call-back Survey, 2011-2012.
CONCLUSIONS: Results indicated substantial agreement between current and active asthma. Agreement was strengthened when talking to a doctor about asthma was removed from the active asthma classification. PMID: 27050506 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Epidemiology of Asthma-Related Disability in the U.S. Armed Forces: 2007-2012.
CONCLUSIONS: New-onset asthma occurring after military entry often causes occupational impairment in service members, especially in those that have been deployed to Iraq or Afghanistan. PMID: 27050635 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

The management of asthma in the phenotype and biomarker era: the proposal of a new diagnostic-therapeutic model.
We present here a proposal for this model. PMID: 27050723 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Impact of the Arg 16 Allele of the B2AR Gene on the Effect of Withdrawal of LABA in Patients with Moderate to Severe Asthma.
CONCLUSIONS: Withdrawal of LABA therapy in asthmatics with the Arg/Arg genotype at the 16(th) amino acid position of B2AR did not lead to significant improvement in AM PEFR. LABA withdrawal in the Gly/Gly genotype however led to a borderline significant decline in AM PEFR. PMID: 27050801 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Irreversible airway obstruction in asthma: a risk factor for severe exacerbations in spite of proper treatment.
CONCLUSION: IAO is not a risk factor for poor symptoms control or poor quality of life, in a setting of proper treatment. It is a risk factor for emergency room visit and hospital admission. Subjects with IAO have poor response to treatment. PMID: 27050870 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort.
This study tested expression and correlation between GWAS-identified asthma genes and asthma or asthma severity. METHODS: Correlation analyses of expression levels of GWAS-identified asthma genes and asthma-related biomarkers were performed in cells from human bronchial epithelial biopsy (BEC, n = 107) and bronchial alveolar lavage (BAL, n = 94). RESULTS: Expression levels of asthma genes between BEC and BAL and with asthma or asthma severity were weakly correlated. The expression levels of IL18R1 were consistently higher in asthma than controls or in severe asthma than mild/moderate asthma in BEC and BAL (p
Source: Journal of Asthma - April 8, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Bronchodilator responsiveness in wheezy infants predicts continued early childhood respiratory morbidity.
Authors: Shavit S, Cohen S, Goldman A, Ben-Dov L, Avital A, Springer C, Hevroni A Abstract OBJECTIVE: Spirometry including bronchodilator responsiveness is considered routine in the workup of asthma in older children. However, in wheezy infants the existence of bronchodilator responsiveness and its prognostic significance remain unclear. METHODS: Infants (
Source: Journal of Asthma - April 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Patient-physician relationship in the management of asthma: Multicentric approach in Latin America.
CONCLUSIONS: A high percentage of the Latin American physicians surveyed rated themselves very likely to use good communication strategies when managing asthma patients and felt that asthma control can be achieved in most or almost all patients. PMID: 27042878 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - April 6, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research