Atriofascicular pathway detection with novel ablation catheter
Publication date: Available online 25 April 2016 Source:Journal of Arrhythmia Author(s): Padmanabhan Shakkottai, Adrian Baranchuk, Neil Hobson, Jane Caldwell Atriofascicular pathways are a rare cause of antidromic atrioventricular reciprocating tachycardia. The IntellaTip MiFi ablation catheter (Boston Scientific, MA, USA) is a novel ablation catheter that allows enhanced signal clarity with highly localized electrograms. This is the first report of this catheter being successfully used to map and ablate the atriofascicular pathway potentials. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - April 25, 2016 Category: Cardiology Source Type: research

Temporal sinus node modification by high-dose continuous intravenous administration of landiolol in a patient with persistent inappropriate sinus tachycardia
Publication date: Available online 25 April 2016 Source:Journal of Arrhythmia Author(s): Yuichi Hori, Shiro Nakahara, Naofumi Anjo, Yoshihiko Sakai, Isao Taguchi A 20-year-old woman underwent an electrophysiological study for drug-resistant persistent inappropriate sinus tachycardia (IST). Use of a high-dose continuous intravenous administration of landiolol, a short-acting beta-adrenoreceptor blocker, made the patient׳s heart rate suddenly drop with a slight change in the P-wave morphology. Three-dimensional right atrial (RA) activation mapping revealed that the earliest activation site moved 8mm to a lower anteri...
Source: Journal of Arrhythmia - April 25, 2016 Category: Cardiology Source Type: research

Efficacy of atorvastatin in prevention of atrial fibrillation after heart valve surgery in the PROFACE trial (PROphylaxis of postoperative atrial Fibrillation After Cardiac surgEry)
Conclusions Atorvastatin in the described dose, was not adequate for the prophylaxis of POAF after heart valve surgery. It was ineffective in controlling the inflammatory phenomena, myocardial injury, and echocardiographic predictors of POAF. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 28, 2016 Category: Cardiology Source Type: research

Cardiac dynamics: Alternans and arrhythmogenesis
Publication date: Available online 28 March 2016 Source:Journal of Arrhythmia Author(s): Gary Tse, Sheung Ting Wong, Vivian Tse, Yee Ting Lee, Hiu Yu Lin, Jie Ming Yeo Pre-existing heterogeneities present in cardiac tissue are essential for maintaining the normal electrical and mechanical functions of the heart. Exacerbation of such heterogeneities or the emergence of dynamic factors can produce repolarization alternans, which are beat-to-beat alternations in the action potential time course. Traditionally, this was explained by restitution, but additional factors, such as cardiac memory, calcium handling dynamics,...
Source: Journal of Arrhythmia - March 27, 2016 Category: Cardiology Source Type: research

Lead extractions in patients with cardiac implantable electronic device infections: Single center experience
Conclusion The current status of CIED infections in Japan seems to be similar to that previously reported from foreign countries. The optimal treatment of CIED infections involves the complete explantation of all hardware, followed by antibiotic therapy. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 21, 2016 Category: Cardiology Source Type: research

Double twiddle trouble, a new variant of twiddler syndrome
We describe the first reported case of a dramatic pacemaker lead coiling with a double level of lead compromise, with one of them being intra-cardiac. This condition affected our treatment strategy, as the repositioning of the lead was unfeasible. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 21, 2016 Category: Cardiology Source Type: research

New horizon for infection prevention technology and implantable device
Publication date: Available online 19 March 2016 Source:Journal of Arrhythmia Author(s): Yusuke Kondo, Marehiko Ueda, Yoshio Kobayashi, Joerg O. Schwab There has been a significant increase in the number of patients receiving cardiovascular implantable electronic devices (CIED) over the last two decades. CIED infection represents a serious complication after CIED implantation and is associated with significant morbidity and mortality. Recently, newly advanced technologies have offered attractive and suitable therapeutic alternatives. Notably, the leadless pacemaker and anti-bacterial envelope decrease the potential r...
Source: Journal of Arrhythmia - March 19, 2016 Category: Cardiology Source Type: research

ST elevation without cardio-pulmonary symptoms
Publication date: Available online 17 March 2016 Source:Journal of Arrhythmia Author(s): Priyank Shah, Rahul Vasudev, Fayez Shamoon (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 18, 2016 Category: Cardiology Source Type: research

Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban
Publication date: Available online 15 March 2016 Source:Journal of Arrhythmia Author(s): Yosuke Miwa, Toshinori Minamishima, Toshiaki Sato, Konomi Sakata, Hideaki Yoshino, Kyoko Soejima The majority of embolisms associated with atrial fibrillation (AF) are from the left atrial appendage (LAA). To treat the existing thrombus, warfarin and novel anticoagulants have been used. However, there has been no clinical information regarding the difference of the effects of congealing the fibrinogenolysis system among these oral anticoagulants. Here, we report a case of persistent AF, in whom apixaban, factor Xa inhibitor res...
Source: Journal of Arrhythmia - March 16, 2016 Category: Cardiology Source Type: research

Clinical and genetic features of Australian families with long QT syndrome: A registry-based study
Conclusions This is the first clinical and genetic study in a large cohort of Australian families with LQTS. Findings from this study suggest that the clinical and genetic features in this population are not dissimilar to those described in North American, European, and Asian cohorts. Global-scale information about families with LQTS is an important initiative to ensure diagnostic and management approaches are applicable to different populations and ethnicities. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 16, 2016 Category: Cardiology Source Type: research

The feasibility of a Box isolation strategy for non-paroxysmal atrial fibrillation in elderly patients
Conclusions Box isolation of non-PAF is effective and safe even in elderly patients. A prophylactic CTI ablation combined with Box isolation might be feasible to improve the long-term outcome. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 16, 2016 Category: Cardiology Source Type: research

Efficacy of atrial substrate modification based on dominant frequency of paroxysmal atrial fibrillation
Conclusions Atrial substrate ablation may improve the clinical outcome after ablation in patients after PVI with residual arrhythmia inducibility. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 14, 2016 Category: Cardiology Source Type: research

Anti-arrhythmic medications increase non-cardiac mortality – A meta-analysis of randomized control trials
Conclusion AAMs are associated with an increased risk of non-cardiac and all-cause mortality. The effect of AAMs, especially amiodarone, on non-cardiac mortality requires further evaluation. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - March 11, 2016 Category: Cardiology Source Type: research

The genetic background of arrhythmogenic right ventricular cardiomyopathy
Publication date: Available online 26 February 2016 Source:Journal of Arrhythmia Author(s): Seiko Ohno Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by degeneration of the right ventricle and ventricular tachycardia originating from the right ventricle. Additionally, the disease is an inherited cardiomyopathy that mainly follows the autosomal dominant pattern. More than 10 genes have been reported as causative genes for ARVC, and more than half of ARVC patients carry mutations in desmosome related genes. The desmosome is one of the structures involved in cell adhesion and its disruption leads t...
Source: Journal of Arrhythmia - February 26, 2016 Category: Cardiology Source Type: research

Intermuscular pocket for subcutaneous implantable cardioverter defibrillator: Single-center experience
Publication date: Available online 23 February 2016 Source:Journal of Arrhythmia Author(s): Paola Ferrari, Fabrizio Giofrè, Paolo De Filippo The subcutaneous implantable cardioverter defibrillator (S-ICD) is a novel device now accepted in clinical practice for treating ventricular arrhythmias. In 14 consecutive patients, S-ICD devices were placed in the virtual space between the anterior surface of the serratus anterior muscle and the posterior surface of the latissimus dorsi muscle. During a mean follow up of 9 months, no dislocations, infections, hematoma formations, or skin erosions were observed. Intermuscu...
Source: Journal of Arrhythmia - February 24, 2016 Category: Cardiology Source Type: research

Eccentric scar formation around a pulmonary vein after cryo-balloon ablation in a patient with atrial fibrillation: A case report
Publication date: Available online 23 February 2016 Source:Journal of Arrhythmia Author(s): Kunihiko Kiuchi, Koji Fukuzawa, Akinori Matsumoto The impact of a cryoballoon ablation is reported to be similar to that of a radiofrequency (RF) ablation in patients with atrial fibrillation. Delayed enhancement magnetic resonance imaging (DE-MRI) could visualize the scar region induced by the cryoballoon ablation as well as RF ablation. Cryoballoon ablation could induce extensive scar lesions around the PVs. However, the distribution of the scar lesions after the cryoballoon ablation has not been well discussed. We, herein, d...
Source: Journal of Arrhythmia - February 24, 2016 Category: Cardiology Source Type: research

Radiofrequency catheter ablation of left-sided accessory pathways via retrograde aortic approach in children
Conclusions The retrograde aortic approach can be safely employed with a high success rate for ablation of left-sided accessory pathways in children. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 12, 2016 Category: Cardiology Source Type: research

Ischemic Brugada phenocopy during ablation of ventricular tachycardia
Publication date: Available online 9 February 2016 Source:Journal of Arrhythmia Author(s): Byron H. Gottschalk, Daniel D. Anselm, Adrian Baranchuk (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 10, 2016 Category: Cardiology Source Type: research

Atrial arrhythmias in inherited arrhythmogenic disorders
Publication date: Available online 9 February 2016 Source:Journal of Arrhythmia Author(s): Can Hasdemir Atrial arrhythmias are being increasingly recognized in inherited arrhythmogenic disorders particularly in patients with Brugada syndrome and short QT syndrome. Atrial arrhythmias in inherited arrhythmogenic disorders have significant epidemiologic, clinical, and prognostic implications. There has been progress in the understanding of underlying genetic characteristics and the mechanistic link between atrial arrhythmias and inherited arrhythmogenic disorders. Appropriate management of these patients is of paramount im...
Source: Journal of Arrhythmia - February 10, 2016 Category: Cardiology Source Type: research

A multicenter observational study of the effectiveness of antiarrhythmic agents in ventricular arrhythmias: A propensity-score adjusted analysis
Conclusion Amiodarone and nifekalant are similarly effective in preventing VT recurrence, but their impact on survival rate is minimal. These data indicate that both nifekalant and amiodarone can be used for treatment of refractory VT. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 10, 2016 Category: Cardiology Source Type: research

Alternative approach for management of an electrical storm in Brugada syndrome:Importance of primary ablation within a narrow time window
We report an alternative approach whereby, before ICD implantation, emergency catheter ablation of the VF-triggering premature ventricular contraction (PVC) resulted in long-term VF-free survival. The results suggest that, because VF triggers appear in a narrow time window, ablation of the culprit PVCs that initiate VF before the index PVCs subside is a reasonable alternative approach. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 9, 2016 Category: Cardiology Source Type: research

Successful dual chamber ICD implantation via a persistent left superior vena cava after ratchet syndrome
Publication date: Available online 6 February 2016 Source:Journal of Arrhythmia Author(s): Naofumi Anjo, Shiro Nakahara, Tohru Kamijima, Yuichi Hori, Ayako Nakagawa, Naoki Nishiyama, Kouta Yamada, Takaaki Komatsu, Sayuki Kobayashi, Yoshihiko Sakai, Isao Taguchi (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 8, 2016 Category: Cardiology Source Type: research

Recent advances in genetic testing and counseling for inherited arrhythmias
This article discusses indications for genetic testing of patients with inherited arrhythmias. Further, it describes the benefits and challenges that we face in the era of next generation sequencing. Finally, it briefly discusses genetic counseling, in which a multidisciplinary approach is required due to the increased complexity of the genetic information related to inherited arrhythmias. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 6, 2016 Category: Cardiology Source Type: research

Clinical and electrocardiographic predictors of T wave oversensing in patients with subcutaneous ICD
Conclusion In this study, younger age, higher ejection fraction, and lower QRS amplitude were associated with TWOS. These findings could help identify patients referred for S-ICD at high-risk of TWOS. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 6, 2016 Category: Cardiology Source Type: research

Localized rotors and focal impulse sources within the left atrium in human atrial fibrillation: A phase analysis of contact basket catheter electrograms
Conclusion Localized rotors and focal impulses can be identified on phase maps of atrial fibrillation in a small number of patients. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - February 4, 2016 Category: Cardiology Source Type: research

Histological examination of the right atrial appendage after failed catheter ablation for focal atrial tachycardia complicated by cardiogenic shock in a post-partum patient
Publication date: Available online 3 February 2016 Source:Journal of Arrhythmia Author(s): Akira Mizukami, Makoto Suzuki, Rena Nakamura, Shunsuke Kuroda, Maki Ono, Yuya Matsue, Ryota Iwatsuka, Taishi Yonetsu, Akihiko Matsumura, Yuji Hashimoto A 26-year-old woman in her first pregnancy presented with persistent atrial tachycardia (AT). AT was resistant to medications, cardioversions, and the first attempt of catheter ablation. Two months after delivery she developed severe systolic dysfunction and circulatory collapse. Emergent catheter ablation was performed with the support of percutaneous cardiopulmonary bypa...
Source: Journal of Arrhythmia - February 4, 2016 Category: Cardiology Source Type: research

2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing
Publication date: Available online 1 February 2016 Source:Journal of Arrhythmia Author(s): Bruce L. Wilkoff, Laurent Fauchier, Martin K. Stiles, Carlos A. Morillo, Sana M. Al-Khatib, Jesœs Almendral, Luis Aguinaga, Ronald D. Berger, Alejandro Cuesta, James P. Daubert, Sergio Dubner, Kenneth A. Ellenbogen, N.A. Mark Estes, Guilherme Fenelon, Fermin C. Garcia, Maurizio Gasparini, David E. Haines, Jeff S. Healey, Jodie L. Hurtwitz, Roberto Keegan, Christof Kolb, Karl-Heinz Kuck, Germanas Marinskis, Martino Martinelli, Mark McGuire, Luis G. Molina, Ken Okumura, Alessandro Proclemer, Andrea M...
Source: Journal of Arrhythmia - February 1, 2016 Category: Cardiology Source Type: research

Molecular pathogenesis of long QT syndrome type 1
Publication date: Available online 27 January 2016 Source:Journal of Arrhythmia Author(s): Jie Wu, Wei-Guang Ding, Minoru Horie Long QT syndrome type 1 (LQT1) is a subtype of a congenital cardiac syndrome caused by mutation in the KCNQ1 gene, which encodes the α-subunit of the slow component of delayed rectifier K+ current (I Ks) channel. Arrhythmias in LQT1 are characterized by prolongation of the QT interval on ECG, as well as the occurrence of life-threatening cardiac events, frequently triggered by adrenergic stimuli (e.g., physical or emotional stress). During the past two decades, much advancement has been...
Source: Journal of Arrhythmia - January 29, 2016 Category: Cardiology Source Type: research

Impact of transesophageal echocardiography during transseptal puncture on atrial fibrillation ablation
Conclusions TEE-guided TP for AF ablation is associated with shorter fluoroscopy time, shorter total cryoablation time, and shorter total procedural time. Importantly, TEE-guided TP facilitates cryoablation of the inferior pulmonary veins. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 29, 2016 Category: Cardiology Source Type: research

Home monitoring report from a single lead Lumax DX implantable cardioverter defibrillator: New observations in a new system
Publication date: Available online 25 January 2016 Source:Journal of Arrhythmia Author(s): Yuval Konstantino, Alex Kleiman, Guy Amit A 56-year-old man underwent a single lead Lumax 640 DX implantable cardioverter defibrillator implantation for primary prevention of sudden cardiac death. A DX system consists of a single lead, which provides atrial as well as ventricular electrograms, and enhances atrial arrhythmia detection. Three months after the implantation, high-frequency episodes were detected on the far field and the atrial channels, but not on the bipolar right ventricular channel; these were classified as atria...
Source: Journal of Arrhythmia - January 26, 2016 Category: Cardiology Source Type: research

Molecular pathogenesis of long QT syndrome type 2
Publication date: Available online 22 January 2016 Source:Journal of Arrhythmia Author(s): Jennifer L. Smith, Corey L. Anderson, Don E. Burgess, Claude S. Elayi, Craig T. January, Brian P. Delisle The molecular mechanisms underlying congenital long QT syndrome (LQTS) are now beginning to be understood. New insights into the etiology and therapeutic strategies are emerging from heterologous expression studies of LQTS-linked mutant proteins, as well as inducible pluripotent stem cell derived cardiomyocytes (iPSC-CMs) from LQTS patients. This review focuses on the major molecular mechanism that underlies LQTS type 2 (...
Source: Journal of Arrhythmia - January 23, 2016 Category: Cardiology Source Type: research

Letter to the Editor: Marino et al. Inappropriate mode switching clarified by using a chest radiograph
Publication date: Available online 19 January 2016 Source:Journal of Arrhythmia Author(s): Mohammad Ali Akbarzadeh (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 20, 2016 Category: Cardiology Source Type: research

Management of antithrombotic therapy during cardiac implantable device surgery
Publication date: Available online 18 January 2016 Source:Journal of Arrhythmia Author(s): Ahmed AlTurki, Riccardo Proietti, David H. Birnie, Vidal Essebag Anticoagulants are commonly used drugs that are frequently encountered during device placement. Deciding when to halt or continue the use of anticoagulants is a balance between the risks of thromboembolism versus bleeding. Patients taking warfarin with a high risk of thromboembolism should continue to take their warfarin without interruption during device placement while ensuring their international normalized ratio remains below 3. For patients who are taking war...
Source: Journal of Arrhythmia - January 18, 2016 Category: Cardiology Source Type: research

Post-marketing surveillance on the long-term use of dabigatran in Japanese patients with nonvalvular atrial fibrillation: Preliminary report of the J-dabigatran surveillance
Conclusions The interim findings from this 6148 patient PMS study further corroborate the favorable safety profile of dabigatran as demonstrated previously in controlled clinical trials. (ClinicalTrials.gov number, NCT01491178.) (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 16, 2016 Category: Cardiology Source Type: research

Usefulness of combined CARTO electroanatomical mapping and manifest entrainment in ablating adenosine triphosphate-sensitive atrial tachycardia originating from the atrioventricular node vicinity
Conclusion CARTO mapping- and manifest entrainment-guided ablation strategy is effective and safe in the treatment of ATP-AT. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 14, 2016 Category: Cardiology Source Type: research

Arrhythmia management after device removal
Publication date: Available online 24 October 2015 Source:Journal of Arrhythmia Author(s): Nobuhiro Nishii Arrhythmic management is needed after removal of cardiac implantable electronic devices (CIEDs). Patients completely dependent on CIEDs need temporary device back-up until new CIEDs are implanted. Various methods are available for device back-up, and the appropriate management varies among patients. The duration from CIED removal to implantation of a new CIED also differs among patients. Temporary pacing is needed for patients with bradycardia, a wearable cardioverter defibrillator (WCD) or catheter ablation is nee...
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Autonomic and cardio-respiratory responses to exercise in Brugada Syndrome patients
Conclusion Thai BrS patients had a more rapid rate of restoration of the parasympathetic and smaller level of sympathetic activation after exercise. They had mild hyperkalemia which is reduced according to the exercise. Furthermore, they exhibited impaired cardio-respiratory fitness. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Pseudofusion in a dual chamber pacemaker: Is this pacemaker working properly?
Publication date: Available online 29 October 2015 Source:Journal of Arrhythmia Author(s): Mohammad Ali Akbarzadeh, Abolfath Alizadeh, Negar Bahrololoumi Bafruee (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Left cardiac sympathetic denervation: An important treatment option for patients with hereditary ventricular arrhythmias
Publication date: Available online 29 October 2015 Source:Journal of Arrhythmia Author(s): Yongkeun Cho Medications such as ß-blockers are currently the primary treatment for patients with hereditary arrhythmia syndromes such as long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, these drugs are ineffective in some patients, and the other treatment option, that is implantable cardioverter defibrillator (ICD) implantation, is associated with significant complications in young and active patients. Left cardiac sympathetic denervation (LCSD) may reduce the wide gap betwe...
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Measurement of diffuse ventricular fibrosis with myocardial T1 in patients with atrial fibrillation
Conclusion AF at the time of CMRI was associated with lower post-contrast ventricular T1 compared with sinus rhythm. This effect was at least partly due to elevated heart rate. T1 was not associated with the recurrence of AF after ablation. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Practical applicability of landiolol, an ultra-short-acting β1-selective blocker, for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction
Conclusions Landiolol is effective in patients with heart failure not only due to rapid AF/AFL but also due to VTs. However, preserved LVEF is important for efficacy and safety in landiolol treatment. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Development of an alert system for subjects with paroxysmal atrial fibrillation
Conclusion This method of analysis of RR interval data shows potential use to alert a PAF subject before the onset of an AF episode. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Takotsubo syndrome and polymorphic ventricular tachycardia: The chicken or the egg
Publication date: Available online 3 November 2015 Source:Journal of Arrhythmia Author(s): John E. Madias (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Incidence of cardiac implantable electronic device infections and migrations in Japan: Results from a 129 institute survey
Conclusions This survey was the first on CIED infection and migration in Japan. The CIED infection rate (1.12%) was similar to that previously reported. A high infection rate (2.77%) was observed in the infection experienced institutes. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

A case report of successful permanent pacemaker implantation via the iliac vein
Publication date: Available online 11 November 2015 Source:Journal of Arrhythmia Author(s): Tetsuo Yamaguchi, Takamichi Miyamoto, Yasuteru Yamauchi, Tohru Obayashi An 85-year-old man was referred to our hospital with a pacemaker pocket infection. A permanent pacemaker had been implanted via the right subclavian vein. The pacemaker and pacing leads were removed and a temporary pacemaker was implanted. After vancomycin treatment for 4 weeks, pacemaker implantation via the right external iliac vein was performed under local anesthesia because of left subclavian vein occlusion, infection of the right pocket, and difficul...
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Influence of primary and secondary prevention indications on anxiety about the implantable cardioverter-defibrillator
Conclusions In our study population, which mostly consisted of New York Heart Association (NYHA) class I and II subjects, primary prevention ICD recipients were more prone to experience worries about their ICD, anxiety, and a poorer QOL compared to secondary prevention ICD recipients. In clinical practice, primary prevention ICD patients should be closely monitored. If warranted, they should be offered psychological intervention, as anxiety and low QOL were predictors of mortality. (Source: Journal of Arrhythmia)
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Molecular autopsy in victims of inherited arrhythmias
Publication date: Available online 19 November 2015 Source:Journal of Arrhythmia Author(s): Christopher Semsarian, Jodie Ingles Sudden cardiac death (SCD) is a rare but devastating complication of a number of underlying cardiovascular diseases. While coronary artery disease and acute myocardial infarction are the most common causes of SCD in older populations, inherited cardiac disorders comprise a substantial proportion of SCD cases aged less than 40 years. Inherited cardiac disorders include primary inherited arrhythmogenic disorders such as familial long QT syndrome (LQTS), Brugada syndrome (BrS), catecholaminergic ...
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Conservative therapy for the management of cardiac implantable electronic device infection
Publication date: Available online 19 November 2015 Source:Journal of Arrhythmia Author(s): Yukio Sekiguchi Along with the increased frequency of implantation, the incidence of cardiac implantable electronic device (CIED) infection, which can have serious or fatal complications, has also increased. Although several successful conservative therapies for CIED infection have been reported, retained infected devices remain a source of relapse, which is closely related to a higher mortality rate. Presently, complete hardware removal is initially recommended for infected CIED patients, and indications for conservative therapy...
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Inherited bradyarrhythmia: A diverse genetic background
Publication date: Available online 19 November 2015 Source:Journal of Arrhythmia Author(s): Taisuke Ishikawa, Yukiomi Tsuji, Naomasa Makita Bradyarrhythmia is a common heart rhythm abnormality comprising number of diseases and is associated with decreased heart rate due to the failure of action potential generation and propagation at the sinus node. Permanent pacemaker implantation is often used therapeutically to compensate for decreased heart rate and cardiac output. The vast majority of bradyarrhythmia cases are attributable either to aging or to structural abnormalities of the cardiac conduction system, caused by ...
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research

Successful intraprocedural anticoagulation with bivalirudin during pulmonary vein isolation in a patient with known heparin-induced thrombocytopenia type II
We report the case of a 56-year-old female who presented with symptomatic paroxysmal atrial fibrillation. Anamnestic heparin-induced thrombocytopenia (HIT) type II was suspected, and a rapid diagnostic test showed antibodies against platelet factor 4. The heparin-induced platelet activation-assay was negative. Radiofrequency pulmonary vein isolation with intraprocedural anticoagulation using bivalirudin was ultimately performed. Dosing was controlled by monitoring the activated clotting time. Post-procedural blood tests were normal. There were no thromboembolic or bleeding events. Bivalirudin is a therapeutic option for an...
Source: Journal of Arrhythmia - January 11, 2016 Category: Cardiology Source Type: research