A randomized, prospective clinical study evaluating effectiveness of a bulk-fill composite resin, a conventional composite resin and a reinforced glass ionomer in Class II cavities: one-year results
Conclusion: Bulk-fill composite resins and conventional composite resins showed more successful clinical performance than highly viscous reinforced glass ionomers in Class II cavities. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research
Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats
Conclusion: The incorporation of PEO at 20% and 30% into PMMA fiber mat resulted in effective drug release systems, with detected antibacterial activity against S. mutans. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research
DNA hypermethylation of Fgf16 and Tbx22 associated with cleft palate during palatal fusion
Conclusions: Taken together, these results suggest that hypermethylation of Fgf16 and Tbx22 is associated with decreased gene expression, which might be responsible for developmental failure of palatal fusion, eventually resulting in the formation of CP. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research
Comparison of two soft tissue substitutes for the treatment of gingival recession defects: an animal histological study
Conclusions: Both porcine-derived ADM and CBM revealed similar histological outcomes with successful integration and absence of adverse events. Test group provided superior outcomes regarding root coverage and increase in tissue thickness. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research
Losartan improves alveolar bone dynamics in normotensive rats but not in hypertensive rats
Conclusion: Losartan can improve bone mineralization parameters under normal physiological conditions, but the same anabolic effect does not occur under hypertension. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research
Quantification of pro-inflammatory cytokines and osteoclastogenesis markers in successful and failed orthodontic mini-implants
Conclusions: It may be concluded that the expression of IL-1 α , IL-17, TNF- α , RANK, RANKL, and OPG in peri-implant gingival tissue were not determinant for mini-implant stability loss, but the higher IL-6 expression could be associated with mini-implant failure. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research
To P or not to P, is that the question? Rethinking experimental design and data analysis to improve biological significance beyond the statistical significance
(Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 8, 2019 Category: Dentistry Source Type: research
Clinical attachment loss and molecular profile of inflamed sites before treatment
Conclusions: Clinical attachment loss is a negative event that may occur even after successful basic periodontal therapy, but it is small and limited to a small percentage of sites. Elevated inflammation markers of inflamed sites from disease patients reduced to the mean levels of those observed in healthy subjects after successful basic periodontal therapy. Significantly elevated both gene and protein levels of IL-10 in inflamed sites prior treatment confirms its modulatory role in the disease status. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - September 10, 2019 Category: Dentistry Source Type: research
Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis
Conclusion: ASU administration improves the repair of periodontal tissues in an experimental periodontitis model in rats with induced arthritis. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - September 10, 2019 Category: Dentistry Source Type: research
Role of Candida albicans on enamel demineralization and on acidogenic potential of Streptococcus mutans in vitro biofilms
Conclusions: The present data suggest that C. albicans has low enamel demineralization potential and the presence of C. albicans can reduce both the cariogenic and acidogenic potentials of S. mutans biofilms. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - September 10, 2019 Category: Dentistry Source Type: research
Effect of sonic and ultrasonic activation on physicochemical properties of root canal sealers
Conclusions: UA and SA promoted changes in the physicochemical properties of the evaluated root canal sealers, mainly in ST and F. Thus, it is important to evaluate the physicochemical properties of endodontic sealers associated with activation techniques prior to clinical application in order to determine whether the properties follow the parameters set by ANSI/ADA, ensuring safety and quality of root canal filling. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - September 10, 2019 Category: Dentistry Source Type: research
Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study
Conclusion: A high expression of SOX2 was associated with better disease-free survival. The expression of podoplanin was associated with the degree of differentiation of the tumors. Analysis of these biomarkers can aid in the prognosis and treatment of oral squamous cell carcinomas. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - September 10, 2019 Category: Dentistry Source Type: research
Influence of the incorporation of triclosan methacrylate on the physical properties and antibacterial activity of resin composite
Abstract The incorporation of antimicrobials in the composites as an attempt to reduce bacterial adhesion without jeopardizing mechanical properties is a challenge for Dentistry. Objective: To evaluate the bacterial adhesion and physical properties of a composite containing the methacrylate triclosan- derivative monomer (TM). Methodology: TM was synthesized and added to an experimental composite. Samples were divided into two groups: Control and TM (13.4 wt%). Antibacterial Activity: Three specimens of each material were prepared and placed on bacterial suspensions of Streptococcus mutans for 1, 5 and 10 days. After thes...
Source: Journal of Applied Oral Science - September 10, 2019 Category: Dentistry Source Type: research
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases
Abstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specifi...
Source: Journal of Applied Oral Science - September 10, 2019 Category: Dentistry Source Type: research
Impact of immediately loaded implant-supported maxillary full-arch dental prostheses: a systematic review
Conclusions This review found weak evidence of differences between immediate load and other loading regimens, regarding patient satisfaction and maintenance events/adversities. The potential of immediate loading for favorable results in edentulous maxillae reinforces the need for well-designed RCTs, for solid clinical guidelines. Registration number CRD42018071316 (PROSPERO database). (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - August 13, 2019 Category: Dentistry Source Type: research
