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Differential response to antibiotic therapy in staphylococcal infective endocarditis: contribution of an ex vivo model
ConclusionsThese data highlight a strong bactericidal effect of dalbavancin, particularly on an infected heart valve compared with vancomycin. Dalbavancin could be a realistic alternative treatment for the management of staphylococcal IE. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

Implementation of WGS analysis of ESBL-producing Escherichia coli within EU AMR monitoring in livestock and meat
ConclusionsFurther implementation of WGS analysis of ESBL/AmpC-producingE. coli within the AMR monitoring programme of EU member states and global surveillance programmes will contribute to determining the attribution of livestock in the prevalence of ESBL/AmpC-encodingE. coli in humans. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

Impact of a prospective audit and feedback antimicrobial stewardship programme on carbapenem consumption: a quasi-experimental study (IPANEMA study)
ConclusionsThe implementation of PAF combined with an electronic tool was an effective and safe intervention for reducing carbapenem use. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

Maintenance darunavir/ritonavir monotherapy to prevent perinatal HIV transmission, ANRS-MIE 168 MONOGEST study
ConclusionsDarunavir/ritonavir maintenance monotherapy required intensification in nearly 10% of cases. This limits its widespread use, thus other regimens should be evaluated in order to limit exposure to antiretrovirals, particularly NRTIs, during pregnancy. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

Towards optimizing carbapenem selection in stewardship strategies: a prospective propensity score-matched study of ertapenem versus class 2 carbapenems for empirical treatment of third-generation cephalosporin-resistant Enterobacterales bacteraemia
ConclusionsErtapenem may be of comparable efficacy to class 2 carbapenems in the empirical treatment of 3GCRE bacteraemia. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

High-level in vitro resistance to gentamicin acquired in a stepwise manner in Neisseria gonorrhoeae
ConclusionsWe describe the first high-level gentamicin-resistant gonococcal isolate (MIC  = 128 mg/L), which was selectedin vitro through experimental evolution. The most substantial increases of the gentamicin MICs were caused by mutations infusA (G1560A and G1904T encoding EF-G M520I and R635L, respectively) andubiM (D186N). The high-level gentamicin-resistantN. gonorrhoeae mutant showed impaired biofitness. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

In vitro dynamics and mechanisms of cefiderocol resistance development in wild-type, mutator and XDR Pseudomonas aeruginosa
ConclusionsThis work deciphers the potential resistance mechanisms that may emerge upon the introduction of cefiderocol into clinical practice, and highlights that the risk of resistance development might be strain-specific even for XDR high-risk clones. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 30, 2023 Category: Microbiology Source Type: research

Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA Study –authors’ response
We appreciated the letter sent by Ciccullo and Colleagues1 in response to our paper recently published in your Journal.2 They shared the data from their cohort of DTG-treated PLWH, carrying no evidence for a difference in the risk of DTG discontinuation due to toxicity according to sex. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 26, 2023 Category: Microbiology Source Type: research

Genome analysis of an SCCmec element in ST9-MRSA from Myanmar with a unique mec gene complex and two ccr gene complexes (ccrA1B1 and ccrA5B7)
JSPS KAKENHIJP18K10055JP21K10417 (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 25, 2023 Category: Microbiology Source Type: research

Non-randomized evaluation of hospitalization after a prescription for nirmatrelvir/ritonavir versus molnupiravir in high-risk COVID-19 outpatients
ConclusionsThese data provide additional evidence to support molnupiravir as a suitable alternative when other COVID-19 antivirals cannot be given. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 25, 2023 Category: Microbiology Source Type: research

Efficacy of oleylphosphocholine in experimental cutaneous leishmaniasis
ConclusionsTogether, these data suggest that OLPC could be a promising alternative to miltefosine treatment for CL. Further investigations exploring experimental models with additionalLeishmania species and skin pharmacokinetic and dynamic analyses are required. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 25, 2023 Category: Microbiology Source Type: research

Correction to: Simultaneous and divergent evolution of resistance to cephalosporin/ β-lactamase inhibitor combinations and imipenem/relebactam following ceftazidime/avibactam treatment of MDR Pseudomonas aeruginosa infections
This is a correction to: Isaac Alonso-Garc ía and others, Simultaneous and divergent evolution of resistance to cephalosporin/β-lactamase inhibitor combinations and imipenem/relebactam following ceftazidime/avibactam treatment of MDRPseudomonas aeruginosa infections,Journal of Antimicrobial Chemotherapy, Volume 78, Issue 5, May 2023, Pages 1195 –1200,https://doi.org/10.1093/jac/dkad062 (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 24, 2023 Category: Microbiology Source Type: research

Invasive candidiasis: current clinical challenges and unmet needs in adult populations
AbstractInvasive candidiasis (IC) is a serious infection caused by severalCandida species, and the most common fungal disease in hospitals in high-income countries. Despite overall improvements in health systems and ICU care in the last few decades, as well as the development of different antifungals and microbiological techniques, mortality rates in IC have not substantially improved. The aim of this review is to summarize the main issues underlying the management of adults affected by IC, focusing on specific forms of the infection: IC developed by ICU patients, IC observed in haematological patients, breakthrough candid...
Source: Journal of Antimicrobial Chemotherapy - May 23, 2023 Category: Microbiology Source Type: research

Comment on: Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA study
ViiV Healthcare10.13039/100010877 (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 23, 2023 Category: Microbiology Source Type: research

Antibiotic prescription patterns during last days of hospitalized patients with advanced cancer: the role of palliative care consultation
ConclusionReceiving palliative care consultation may minimize aggressive antibiotic prescription patterns in the last days of patients with advanced cancer in an academic referral centre setting. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 23, 2023 Category: Microbiology Source Type: research