Journal of Antimicrobial Chemotherapy This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Identification of Tn553, a novel Tn554-related transposon that carries a complete blaZ-blaR1-blaI β-lactamase operon in Staphylococcus aureus
German Research FoundationSCHW382/11 –1National Natural Science Foundation of China10.13039/5011000018093176113302281861138051 (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - June 24, 2021 Category: Microbiology Source Type: research

Erratum to: Characterization of Klebsiella pneumoniae complex isolates from pigs and humans in farms in Thailand: population genomic structure, antibiotic resistance and virulence genes
J Antimicrob Chemother 2021; doi:10.1093/jac/dkab118 (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - June 14, 2021 Category: Microbiology Source Type: research

Precision dosing of vancomycin: in defence of AUC-guided therapy in children
AbstractIn 2020, new vancomycin guidelines were released, recommending the transition from trough-based to AUC24 monitoring for adult and paediatric patients. Given the resources required to achieve this transition, there has been debate about the costs and benefits of AUC24-based monitoring. A recent narrative review of vancomycin therapeutic drug monitoring in paediatrics claims to have uncovered the methodological weaknesses of the data that informed the guidelines and advises against premature adoption of AUC24-guided monitoring. In this article, we present supporting arguments for AUC24-guided monitoring in children, ...
Source: Journal of Antimicrobial Chemotherapy - June 7, 2021 Category: Microbiology Source Type: research

Activity of plazomicin against carbapenem-intermediate or -resistant Escherichia coli isolates from the United States and international sites in relation to clonal background, resistance genes, co-resistance, and region
ConclusionsThe likely utility of plazomicin against CIRE. coli is high overall, but varies with region and multiple bacterial characteristics. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - June 7, 2021 Category: Microbiology Source Type: research

Redefining therapeutic success in HIV patients: an expert view
This article summarizes the conclusions of these experts and presents the most updated overview on the five topics, along with a discussion of the experts’ main concerns, conclusions and/or recommendations on the most controversial issues. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - June 2, 2021 Category: Microbiology Source Type: research

Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5 ′-triphosphate exposure to support posology for SARS-CoV-2
ConclusionsPopulation mean intracellular FAVI-RTP concentrations are estimated to be maintained above the Km for the SARS-CoV-2 polymerase for 9  days with a 1200 mg twice-daily regimen (following a 1600 mg twice-daily loading dose on day 1). Further evaluation of favipiravir as part of antiviral combinations for SARS-CoV-2 is warranted. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - June 2, 2021 Category: Microbiology Source Type: research

Assessment of intra-sample variability in HIV-1 DNA drug resistance genotyping
ConclusionsThere is an intra-sample variability in HIV-1 DNA resistance test results, and repetition may sometimes bring additional information, but the extent of its clinical impact still requires further investigation. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 29, 2021 Category: Microbiology Source Type: research

Efficacy and safety of sofosbuvir/velpatasvir versus the standard of care in adults hospitalized with COVID-19: a single-centre, randomized controlled trial
ConclusionsAlthough treatment with SOF/VEL was safe, adding SOF/VEL to the standard of care did not improve the clinical status or reduce mortality in patients with moderate to severe COVID-19. However, larger randomized clinical trials including more parameters are needed for accurate estimation of the efficacy of SOF/VEL. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 25, 2021 Category: Microbiology Source Type: research

Plasmodium malariae and Plasmodium falciparum comparative susceptibility to antimalarial drugs in Mali
ConclusionsOur data indicated that chloroquine, lumefantrine and artemether may not be suitable for the treatment ofP. malariae infections and the potential of piperaquine, as well as new antimalarials imidazolopiperazines and PI4K-specific inhibitor, forP. malariae cure. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 22, 2021 Category: Microbiology Source Type: research

The feasibility of implementing antibiotic restrictions for fluoroquinolones and cephalosporins: a mixed-methods study across 15 Veterans Health Administration hospitals
ConclusionsAcross 15 hospitals, there were differing opinions on the feasibility of implementing antibiotic restrictions for third/fourth-generation cephalosporins and fluoroquinolones. While the perceived barrier to implementing restrictions was frequently high, many hospitals were effectively using restrictions and reported few barriers to their use. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 20, 2021 Category: Microbiology Source Type: research

Deciphering mobile genetic elements disseminating macrolide resistance in Streptococcus pyogenes over a 21 year period in Barcelona, Spain
ConclusionsWe detected several different MGEs harbouringerm(B) orerm(TR). This is the first known description of Tn6263 in GAS and three MGEs [IMESp316HUB, ICESp3729HUB and ICESp1070HUB] associated with MR. Periods of high MR rates in our area were mainly associated with the expansion of certain predominant lineages, while in low MR periods different sporadic and low prevalence lineages were more frequent. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 20, 2021 Category: Microbiology Source Type: research

A brief guide to correct annotation of IS26 and variants
Sir, (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 20, 2021 Category: Microbiology Source Type: research

Novel mcr-3.40 variant co-located with mcr-2.3 and blaCTX-M-63 on an IncHI1B/IncFIB plasmid found in Klebsiella pneumoniae from a healthy carrier in Thailand
Sir, (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 20, 2021 Category: Microbiology Source Type: research

A worldwide pharmacovigilance database analysis to assess the risk of acute kidney injury in patients receiving teicoplanin in association with piperacillin, cefepime or meropenem
Sir, (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 19, 2021 Category: Microbiology Source Type: research

Quantification of persister formation of Escherichia coli leveraging electronic cell counting and semi-mechanistic pharmacokinetic/pharmacodynamic modelling
ConclusionsThe developed pharmacokinetic/pharmacodynamic model adequately characterized growth-kill behaviour of threeE. coli isolates and unveiled strain-specific levofloxacin potencies and persister formation. The mimicked dosing regimens did not eradicate the resistant isolates and enhanced persister formation to a strain-specific extent. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 17, 2021 Category: Microbiology Source Type: research