Multivariate analysis of genome-wide data to identify potential pleiotropic genes for five major psychiatric disorders using MetaCCA
Psychiatric disorders represent a mix of common, chronic, and complex conditions affecting populations with highly prevalence (Gaebel et  al., 2015; Jeste et al., 2015; Merikangas et al., 2010). The main clinical disorders include schizophrenia (SCZ), bipolar disorder (BP), major depression (MD), autism spectrum disorders (ASD) and attention deficit-hyperactivity disorder (ADHD), which are characterized by perceptive and cognitive impairments resulting in abnormalities of behavior, volition, and emotion. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 17, 2018 Category: Neurology Authors: XiaoCan Jia, YongLi Yang, YuanCheng Chen, ZhiWei Cheng, Yuhui Du, Zhenhua Xia, Weiping Zhang, Chao Xu, Qiang Zhang, Xin Xia, HongWen Deng, XueZhong Shi Source Type: research

Salivary cortisol reveals overt and hidden anxiety in survivors of childhood cancer attending clinic
There have been significant and continued improvements in the treatment for and survival from childhood cancer over the past few decades. Based on Australian and overseas statistics, the 5 year survival rates have improved to approximately 80% and the majority of these children will go on to become long term survivors (Baade et al., 2010; Gatta et al., 2009; Miller et al., 2016; Ries et al., 2008). Accompanying this increased survival, long-term physical and psychological consequences of cancer therapy are becoming more apparent. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 17, 2018 Category: Neurology Authors: Mazen Amatoury, Ann M. Maguire, Jake Olivier, Belinda Barton, Melissa Gabriel, Luciano Dalla-Pozza, Katharine S. Steinbeck, Robert A. Battisti Tags: Research paper Source Type: research

Societal burden of adolescent depression, an overview and cost-of-illness study
Depression in adolescents is a huge humanistic and societal problem because of the high prevalence rate and high burden of the illness, which could reflect in high societal costs. There are only a few studies that have roughly estimated these costs from national registrations but until now costs related to adolescent depression have not been calculated from a societal perspective using individual patient data. The aim of this article is twofold. First, an overview is given on the prevalence, burden of disease, and estimated costs related to adolescent depression, the latter which is preceded by a short introduction on cost...
Source: Journal of Affective Disorders - July 17, 2018 Category: Neurology Authors: D.H.M. Bodden, Y. Stikkelbroek, C.D. Dirksen Source Type: research

Evaluation of the factor structure, prevalence, and validity of disturbed grief in DSM-5 and ICD-11
The American Psychiatric Association (APA) has made a significant change to the 5th edition of their Diagnostic and Statistical Manual of Mental Disorders (DSM-5, APA, 2013) concerning the classification of disturbed grief, by including Persistent Complex Bereavement Disorder (PCBD). PCBD is included as a condition for further study in Section  3, and can be classified as “Other Specified Trauma- and Stressor-Related Disorder.” PCBD comprises 16 symptoms, organized under two symptom-clusters, namely separation distress and a second symptom-cluster with additional symptoms, that is subdivided into signs of “reactive ...
Source: Journal of Affective Disorders - July 17, 2018 Category: Neurology Authors: Paul A. Boelen, Lonneke I.M Lenferink, Angela Nickerson, Geert E. Smid Source Type: research

Changing of suicide rates in China, 2002 –2015
Suicide is a serious public health problem. Globally, suicide was estimated to account for 788,000 deaths in 2015 (WHO,  2015). From 2000 to 2012, the total number of global suicides decreased by about 9% despite the increase in world population, and the global age-standardized suicide rate fell by 26% (WHO, 2014). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 16, 2018 Category: Neurology Authors: Hui Jiang, Lu Niu, Jessica Hahne, Mi Hu, Jing Fang, Minxue Shen, Shuiyuan Xiao Tags: Research paper Source Type: research

Medical and Non-Medical Marijuana Use in Depression: Longitudinal Associations with Suicidal Ideation, Everyday Functioning, and Psychiatry Service Utilization
The policies and attitudes toward marijuana use are changing in the United States (Volkow et  al., 2014; Volkow et al., 2016; Hasin et al., 2017). As of January 2018, 30 states and the District of Columbia have passed medical marijuana laws (National Conference of State Legislatures, 2018), and fewer adults perceive non-medical marijuana use as risky (Pacek et al., 2015). Although so me adults can use marijuana without harm (Hasin et al., 2016), marijuana users with comorbid psychiatric disorders, such as depression, are at increased risk of experiencing poor symptom and functional outcomes (Bahorik et al., 2013; ...
Source: Journal of Affective Disorders - July 16, 2018 Category: Neurology Authors: Amber L. Bahorik, Stacy A. Sterling, Cynthia I. Campbell, Constance Weisner, Danielle Ramo, Derek D. Satre Tags: Research paper Source Type: research

Thresholds for severity, remission and recovery using the functioning assessment short test (fast) in bipolar disorder
Randomized controlled trials (RCTs) in psychiatry rely on clinician-rated instruments to study the treatment efficacy. Traditionally, the outcomes in RCTs have been defined in a context of reduction of symptoms (response/partial response/non response). However, in the last years, the focus has also moved from clinical remission to functional recovery (Vieta  and Torrent, 2016). Hence, the most meaningful endpoint is no longer mere improvement, nor remission, but recovery. Indeed, functional recovery is, for some patients, a difficult goal, even if they have reached clinical remission. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 16, 2018 Category: Neurology Authors: C.M. Bonn ín, A. Martínez-Arán, M. Reinares, M. Valentí, B. Solé, E. Jiménez, L. Montejo, E. Vieta, A.R. Rosa Source Type: research

Changing of suicide rates in China, 2002-2015
Suicide is a serious public health problem. Globally, suicide was estimated to account for 788,000 deaths in 2015 (WHO,  2015). From 2000 to 2012, the total number of global suicides decreased by about 9% despite the population increase in world population, and the global age-standardized suicide rate fell by 26% (WHO, 2014). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 16, 2018 Category: Neurology Authors: Hui Jiang, Lu Niu, Jessica Hahne, Mi Hu, Jing Fang, Minxue Shen, Shuiyuan Xiao Source Type: research

Gender-related patterns of psychiatric disorder clustering among bariatric surgery candidates: a latent class analysis
Psychiatric disorders are frequent conditions among persons with obesity [Rajan and Menon, 2017; Schmidt et al., 2011]. In general population, obesity and psychiatric disorders affect about 12% and 30% of adult individuals, respectively [NCD Risk factor Collaboration, 2017; GBD 2015 Obesity Collaborators, 2017; Andrade et al., 2012; Kessler et al., 2005]. In U.S. general population with obesity, there is around 25% of increase in odds of mood and anxiety disorders and 25% of decrease in odds of substance use disorders [Simon et al., 2006]. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 16, 2018 Category: Neurology Authors: Leorides Severo Duarte-Guerra, Bruno Mendon ça Coêlho, Marco Aurélio Santo, Francisco Lotufo Neto, Yuan-Pang Wang Tags: Research Paper Source Type: research

Neuron-Related Blood Inflammatory Markers as an Objective Evaluation Tool for Major Depressive Disorder: An Exploratory Pilot Case-Control Study
Major depressive disorder (MDD) is a common psychiatric disorder. The prevalence of MDD is considered to be 4.7% worldwide, and its burden is extremely large (DALYs and Collaborators, 2017; Ferrari et  al., 2013). However, MDD diagnosis and symptom evaluation have depended on subjective information such as physician's clinical experiences and patient's self-assessments, which can unfortunately lead to misdiagnoses (Mitchell et al., 2009). Such difficulties have caused confusion in clinical pra ctice of MDD (Kato et al., 2016; Kato and Kanba, 2017; Kato et al., 2011b; Kato et al., 2011c). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 16, 2018 Category: Neurology Authors: Nobuki Kuwano, Takahiro A. Kato, Masato Mitsuhashi, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Takeshi Sakurai, Shigenobu Kanba Source Type: research

Further Development and Testing of the Metacognitive Model of Procrastination: Self-Reported Academic Performance
Procrastination is characterised by the postponement of engaging in, or the premature termination or completion of, an activity (or activities) pursued to achieve a goal (e.g., Fernie, Bharucha, Nikcevic,& Spada, 2016). In a sample drawn from the populations of six different nations (Australia, Peru, Spain, the United Kingdom, the United States, and Venezuela), the prevalence of ‘arousal’ procrastination (driven by a desire for more excitement and less boredom) was 13.5% and 14.3% for ‘avoidant’ procrastination (motivated by task aversiveness) amongst adults (Ferrari, Díaz-Morales, O'Callaghan, Díaz,& Argumedo, 2...
Source: Journal of Affective Disorders - July 15, 2018 Category: Neurology Authors: Bruce A. Fernie, Umran Y. Kopar, Peter L. Fisher, Marcantonio M. Spada Tags: Research paper Source Type: research

High-Frequency Repetitive TMS for Suicidal Ideation in Adolescents with Depression
Antidepressant Treatment History Form (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 15, 2018 Category: Neurology Authors: Paul E. Croarkin, Paul A. Nakonezny, Zhi-De Deng, Magdalena Romanowicz, Jennifer L. Vande Voort, Deniz Doruk Camsari, Kathryn M. Schak, John D. Port, Charles P. Lewis Source Type: research

Poor evidence for putative abnormalities in cerebrospinal fluid neurotransmitters in patients with depression versus healthy non-psychiatric individuals: A systematic review and meta-analyses of 23 studies
The neurobiological mechanisms in depression are still largely unknown. The diagnosis of MDD largely depends on the clinical interview (Smith et  al., 2013, Ogawa et al., 2015) and no established biochemical marker is available for everyday use in the clinical setting. The identification of objective biological markers that represent pathophysiologic processes could possibly provide biological targets for the development of individual prev ention strategies and new treatments (Mossner et al., 2007). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 15, 2018 Category: Neurology Authors: Josefine Pech, Julie Forman, Lars Vedel Kessing, Ulla Knorr Tags: Review article Source Type: research

Occupational factors associated with major depressive disorder: a Brazilian population-based study
Major depressive disorder (MDD) is one of the most common mental disorders, one of the leading causes of disability and identified as a crucial public health issue because of its high social and economic costs (Greenberg et al., 2015; Kleine-Budde et al., 2013; Stewart et al., 2003). MDD also has serious consequences at the workplace through absenteeism, presenteeism, turn-over and reduced performance and productivity (Wang et al., 2006; Stewart et al., 2003). The identification of risk factors, including occupational risk factors, for MDD is thus important to better understand the disease and implement prevention policies...
Source: Journal of Affective Disorders - July 15, 2018 Category: Neurology Authors: N ágila Soares Xavier Oenning, Patrícia Klarmann Ziegelmann, Bárbara Niegia Garcia de Goulart, Isabelle Niedhammer Tags: Research paper Source Type: research

The Adolescent Grief Inventory: Development of a novel grief measurement
About half of adolescents experience the death of a significant other such as a family member or a friend over a year (Rheingold et al., 2004), and most adolescents lose a relative or friend before adulthood (Harrison and Harrington, 2001). Experiencing a death potentially affects the bereaved adolescent's short- and long-term quality of life (Balk, 2014; Stroebe et al., 2008). Due to biopsychosocial changes in the transition from childhood to adulthood, bereaved adolescents in particular have increased risks of problems related to physical, and mental health and social functioning (Feigelman et al., 2017). (Source: Journa...
Source: Journal of Affective Disorders - July 15, 2018 Category: Neurology Authors: Karl Andriessen, Dusan Hadzi-Pavlovic, Brian Draper, Michael Dudley, Philip B. Mitchell Source Type: research