Microglial markers in the frontal cortex are related to cognitive dysfunctions in major depressive disorder
In response to an increased attention paid to cognitive dysfunctions in major depressive disorder (MDD), numerous recent studies explored the characteristics and clinical significance of impairments in several cognitive domains. In the Sequenced Treatment Alternatives to Relieve Depression (STAR ∗D) study, the majority of patients with MDD reported subjective difficulty with attention and decision making (Sinyor et al., 2010). Moreover, residual cognitive symptoms pose a serious challenge even in euthymic patients (Bora et al., 2013; Hasselbalch et al., 2011; Nierenberg et al., 2010), nec essitating the achievement of co...
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Hua Li, Aadi P. Sagar, Szabolcs K éri Tags: Research paper Source Type: research
Future time perspective, loneliness, and depressive symptoms among middle-aged adults: a mediation model
According to Beck's theory of depression, one of the main features of depression is the feeling that the future is constricted and limited (Kovacs and Beck, 1986). Indeed, research has demonstrated that individuals whose future time perspective (FTP) is limited experience lower levels of subjective well-being and higher levels of depression (Coudin and Lima, 2011). Moreover, recent studies demonstrate that subjective perceptions of time are closely linked with depressive symptoms among older adults, and have emphasized the relevance of these perceptions for clinicians. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Yoav S. Bergman, Dikla Segel-Karpas Source Type: research
Prenatal Maternal Anxiety and Children's Brain Structure and Function: A Systematic Review of Neuroimaging Studies
Mental illness is common prenatally and postpartum, with up to 25% of women experiencing a pathological level of stress, anxiety, and/or depression during the perinatal period (Kingston et al., 2012). Mental illness during and after pregnancy can impact the fetus and child, with effects including lower Apgar scores in newborns, increased emotional problems, and risk for mental health difficulties in children and adolescents (Stein et al., 2014). Prenatal anxiety disorders spec ifically increase the likelihood of premature birth and low birthweight infants (Rondo et al., 2003; Wadhwa et al., 1993), negatively affecti...
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Brianna Adamson, Nicole Letourneau, Catherine Lebel Tags: Review article Source Type: research
Associations between executive function impairment and biochemical abnormalities in bipolar disorder with suicidal ideation
This study aimed to assess alterations of execution function and biochemical metabolism in BD with SI, in BD without SI, and in healthy controls. The associations between execution function and biochemical metabolism in the two BD patient groups were also been studied. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Shuming Zhong, Ying Wang, Shunkai Lai, Tao Liu, Xiaoxiao Liao, Guanmao Chen, Yanbin Jia Tags: Research paper Source Type: research
The Darknet and Suicide
A Darknet is a part of the Internet that is not accessible by conventional search engines, such as Google. It is a closed ( “overlay”) network, available to all internet users who install specific software, such as The Onion Router (TOR), Freenet or I2P. This paper presents a study that describes information on suicide available on the Darknet accessible via the TOR software, its nature and its accessibility to the g eneral public. Before presenting our study, we describe the TOR Darknet in relation to the Surface Web, and studies to date on internet suicide content. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Carl-Maria M örch, Louis-Philippe Côté, Laurent Corthésy-Blondin, Léa Plourde-Léveillé, Luc Dargis, Brian L. Mishara Tags: Research paper Source Type: research
Social networks of patients with chronic depression: a systematic review
The term ‘social network’ refers to the social ties that link individuals together through communication (Cohen et al., 1978) and different sets of interactions. Although this term is not precise, it can be characterised more clearly by both the structure of the network (i.e. size, the frequency of conta ct etc.) and the network function (i.e. social support, the content of the relationships) (Santini et al., 2015). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: Chiara Visentini, Megan Cassidy, Victoria Jane Bird, Stefan Priebe Tags: Review article Source Type: research
The Lack of Meaningful Association Between Depression Severity Measures and Neurocognitive Performance
Mild to moderate deficits in neurocognitive functioning are common in major depression (for review see Austin, Mitchell,& Goodwin, 2001; Rock et al., 2014). However, there has been a vexing lack of correlation between measures of depression severity and these neurocognitive deficits that have led to a range of conclusions including that (a) there may not be a consistent association (McClintock et al., 2010), that (b) the association is only evident when considering large numbers of patients across a wide range of depression severity (McDermott& Ebmeier, 2009), or that (c) neurocognitive deficits only occur in a subsample o...
Source: Journal of Affective Disorders - August 8, 2018 Category: Neurology Authors: John G. Keilp, Sean P. Madden, Marianne Gorlyn, Ainsley K. Burke, Maria A. Oquendo, J. John Mann Tags: Research paper Source Type: research
Cardiovascular Risks in Relation to Posttraumatic Stress Severity among Young Trauma-Exposed Women
Research in the area of psychological trauma has revealed a relationship between posttraumatic stress disorder (PTSD) and poor cardiovascular health (Bedi& Arora, 2007; Boscarino& Chang, 1999; Jordan et al., 2011; Kubzansky et al., 2009; Ouimette et al., 2004; Sumner et al., 2015; Xue et al., 2012). Much of this evidence has involved retrospective examination of PTSD status among combat veterans who exhibit clinical symptoms of cardiovascular disease (CVD). Many civilians also suffer from PTSD resulting from the occurrence of threatening incidents including sexual abuse/rape, physical assault, and automobile accidents (e.g...
Source: Journal of Affective Disorders - August 6, 2018 Category: Neurology Authors: Jeffrey L. Kibler, Mindy Ma, Mischa Tursich, Lydia Malcolm, Maria M. Llabre, Rachel Greenbarg, Steven N. Gold, Jean C. Beckham Tags: Research paper Source Type: research
Impulsivity and its association with childhood trauma experiences across bipolar disorder, attention deficit hyperactivity disorder and borderline personality disorder
Impulsivity is usually defined as “a predisposition toward rapid, unplanned reactions to internal or external stimuli without regard to the negative consequences of these reactions to the impulsive individuals or to others’’ (Moeller et al., 2001). Although impulsivity can be present in healthy individuals (Baratt, 1994) an association between impulsivity and mental illness has also been noted since many years (Chamorro et al., 2012; Moeller et al., 2001). Notably, impulsiveness is a core feature of the attention-deficit/hyperactivity disorder (ADHD) (Nandagopal et al., 2011; Matthies& Philipsen, 2014). (Source:...
Source: Journal of Affective Disorders - August 6, 2018 Category: Neurology Authors: H élène Richard-Lepouriel, Anne-Lise Kung, Roland Hasler, Frank Bellivier, Paco Prada, Sébastien Gard, Stefano Ardu, Jean-Pierre Kahn, Alexandre Dayer, Chantal Henry, Jean-Michel Aubry, Marion Leboyer, Nader Perroud, Bruno Etain Source Type: research
Duration of euthymia and predominant polarity in bipolar disorder
The concept of predominant polarity (PP) was introduced by Angst in 1978 and has gained motion in recent years as a course specifier as well as an index of treatment response in bipolar disorder (Carvalho et al., 2014; González-Pinto et al., 2010; Popovic et al., 2012) According to the restrictive definition of PP by the Barcelona group, at least two thirds of the lifetime episodes suffered by a given patient must be manic or depressive to establish manic PP (MPP) or depressive PP (DPP), respective ly (Colom et al., 2006). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 6, 2018 Category: Neurology Authors: Sonia LL. Vidal-Rubio, Vicent Balanz á-Martínez, María Cuenca Torres, Joan Vila-Francés, Eduard Vieta, José E. Romeu Climent Tags: Short communication Source Type: research
The Moderating Role of Social Support for Marital Adjustment, Depression, Anxiety, and Stress: Evidence from Pakistani Working and Nonworking Women
Several previous studies have revealed that individuals ’ mental health and social well-being are influenced by factors such as age, gender, work environment, and socio-economic standings. There are very few studies on social support and the quality of marital satisfaction with a focus on socially anxious couples and their idealistic relationships. Soc ial support might refer to the means of relieving depression, anxiety, and stress for married working and nonworking women. Previous studies evidenced that social support plays an important buffer role against stress and mental distress among married working women (Li, Hof...
Source: Journal of Affective Disorders - August 3, 2018 Category: Neurology Authors: A Jaffar, M Aqeel, J Abbas, B Shaher, J Aman, J Sundas, W Zhang Source Type: research
Differential engagement of cognitive control regions and subgenual cingulate based upon presence or absence of comorbid anxiety with depression
Deficits in cognitive control are a potential mechanism underlying impaired emotion regulation in mood disorders (Langenecker et al. 2014; Langenecker et al., under review; Phillips et al. 2003). Major Depressive Disorder (MDD) is consistently associated with cognitive deficits, including in executive function, working memory and attention (Bora, Harrison et al. 2013; Jenkins et al. 2016; McIntyre et al., 2013; Snyder, 2013). Anxiety Disorders (AD) are also associated with cognitive deficits, although to a lesser extent (Castaneda et al. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 1, 2018 Category: Neurology Authors: Lisanne M. Jenkins, Jonathan P. Stange, Katie L. Bessette, Yi-Shin Chang, Samantha D. Corwin, Kristy A. Skerrett, V íctor G. Patrón, Jon-Kar Zubieta, Natania A. Crane, Alessandra M. Passarotti, Daniel S. Pine, Scott A. Langenecker Tags: Research paper Source Type: research
Child maltreatment, psychopathological symptoms, and onset of diabetes mellitus, hypothyroidism and COPD in adulthood
There is a growing body of evidence that disease suffered in adulthood may originate from maltreatment in childhood (Baumeister et al., 2015; Hostinar et al., 2017; Springer et al., 2003). A recent meta-analysis showed that child maltreatment (CM) contributes to potentially pathogenic pro-inflammatory state in adulthood (Baumeister et al., 2015). The hypothalamic-pituitary-adrenocortical (HPA) axis and neuro-endocrine system helps regulate our stress response, and our immune system (Smith and Vale, 2006). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 1, 2018 Category: Neurology Authors: Mashhood Ahmed Sheikh Tags: Research paper Source Type: research
Impact of Predominant Polarity on Long-term Outcome in Bipolar Disorder: a 7-Year Longitudinal Cohort Study
Bipolar Disorder (BD) is a severe and recurrent psychiatric disorder identified by periodic episodes of depressive and manic symptomatology. It affects approximately 2.4% of the population (Merikangas et al. 2011) and is associated with the highest suicide rate among psychiatric disorders (Goldstein, et al. 2012). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 1, 2018 Category: Neurology Authors: Gabriel Okawa Belizario, Michelle Silva, Beny Lafer Tags: Research paper Source Type: research
Clock genes polymorphisms in male bipolar patients with comorbid alcohol abuse
Statistics show that 65% of bipolar disorder (BD) patients have one psychiatric comorbidity, 42% have two and 24% - three or more (McElroy et al., 2001). What is more, 45% of BD patients have co-morbid alcohol abuse/dependence (AAD) (Farren et al., 2012). Co-transmission of AAD in families has been reported for both disorders (BD and AAD) (Maier and Merikangas, 1996). Adoption studies revealed that substance abuse and BD was more common in biological relatives than in adoptive relatives, what confirms the genetic contribution (Ingraham and Wender, 1992). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - August 1, 2018 Category: Neurology Authors: Ewa Banach, Joanna Pawlak, Pawel Kapelski, Aleksandra Szczepankiewicz, Aleksandra Rajewska-Rager, Maria Skibinska, Piotr Czerski, Joanna Hauser, Monika Dmitrzak-Weglarz Tags: Research paper Source Type: research
