Jornal Brasileiro de Patologia e Medicina Laboratorial This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Acute promyelocytic leukemia: evaluation of diagnostic tests from 2000 to 2018 in a public hospital
Conclusion: Genetic confirmation was observed in 76.1% of samples, 60.2% by conventional cytogenetics and 15.9% by molecular biology. There was a disagreement between the methodologies, and a low sensibility of the conventional cytogenetics, demonstrating the imp ortance of performing molecular techniques for diagnostic confirmation.RESUMEN Introducci ón: La leucemia promielocítica aguda (LPA) es causada por la translocación t(15;17)(q24;q21), cuyo producto es la oncoproteína de fusión PML-RARa (proteína de la leucemia promielocítica-receptor alfa de ácido retinoico). La morfología de los promielocitos leucémi...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - March 2, 2020 Category: Pathology Source Type: research

Influence of interleukins on prognosis of patients with oral squamous cells carcinoma
ABSTRACT Squamous cell carcinoma is a malignant neoplasm that affects the structures and tissues of the oral cavity. Interleukins (IL) synthesized from a tumor modulate a cascade reaction that may influence the prognosis of the disease. We aim to investigate in the literature whether interleukins are mediators that negatively or positively influence the prognosis of patients with oral squamous cell carcinoma. A systematic review study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) instructions. PubMed (including MedLine), Scopus, Web of Science, SciELO and Latin A...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Intraosseous maxillary mucoepidermoid carcinoma: a rare case report
ABSTRACT An unusual case of intraosseous mucoepidermoid carcinoma is reported in a 22-year-old female, located in the posterior maxilla region. The article summarizes the main characteristics of the disease, including clinical-pathologic characteristics, treatment and prognosis.RESUMEN Reportamos un caso raro de carcinoma epidermoide intra óseo ubicado en región posterior de la maxila en una paciente de 22 años de edad. El artículo resume las principales características del proceso neoplásico, incluyendo las características clínico-patológicas, el tratamiento y el pronóstico.RESUMO Relatamos um raro caso de carci...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Ameloblastic carcinoma arising from a preexistent ameloblastoma
ABSTRACT Ameloblastic carcinoma (AC) is a rare odontogenic tumor that represents the malignant counterpart of an ameloblastoma. There are few cases of AC in the English-language literature, with only 16 cases arising from preexisting ameloblastomas reported in the last 10 years. Multiple local recurrences of ameloblastomas precede this transformation. In the current report, we describe a case of AC at the posterior maxilla in a 42-year-old female submitted to surgical resection, with three recurrences of ameloblastoma in a period of four years. Imaging exams showed a radiodense mass with cortical bone disruption and maxill...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Peripheral ossifying fibroma on the mandible: report of atypical presentation case
The objective of the present study is to report the case of a 27-years-old female patient, presenting a lesion in the mandible, complaining of an increased volume. Surgical excision was the treatment of choice. The patient is 24 months postoperatively with no signs of relapse.RESUMEN El fibroma osificante perif érico es una lesión benigna, nodular, firme a la palpación, de base sésil o pediculada, de color similar a la mucosa y al epitelio; puede estar intacto o ulcerado. Se observa más en mujeres y acomete solamente la encía. La lesión se asocia a factores irritantes, como caries, cálculo dental, entre otros. El o...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Dermatoscopy in polypoid basal-cell carcinoma: a rare histopathological variation
We report a clinical case of BCC, with a bibliographical review, highlighting the clinical similarity of such malignant tumor with other benign and malignant tumors of the skin, besides the importance of dermoscopy for the diagnostic aid.RESUMEN El carcinoma basocelular (CBC) polipoide es un tumor raro, considerado como una variante cl ínica e histopatológica del CBC nodular. Presenta amplia base exofítica o pedunculada que se une a la superficie de la piel y exhibe, histopatológicamente, las agregaciones neoplásicas restrictas a la zona polipoide. Reportamos un caso clínico de CBC con revisión de literatura. Destac...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Update of dental and maxillofacial alterations in patients with pycnodysostosis
ABSTRACT Pycnodysostosis is a rare, autosomal recessive genetic condition, which causes a decrease in bone remodeling, resulting in different clinical and radiographic manifestations. This case series aims to describe two clinical cases diagnosed at the Department of Oral and Maxillofacial Surgery and Traumatology of a University on the Northeast of Brazil. There are two complex cases involving osteomyelitis and dental and bone alterations of the jaws. It is concluded that the knowledge of oral and maxillofacial characteristics of this syndrome are required to plan appropriate treatment for patient in order to avoid compli...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Gingival carcinoma cuniculatum mimicking a reactive/inflammatory process
ABSTRACT Carcinoma cuniculatum (CC), a rare variant of oral squamous cell carcinoma, presents well-differentiated neoplastic epithelial cells infiltrating the underlying submucosal or bone tissues, forming the so-called "rabbit burrows" filled with keratin. A 67-year-old female patient was referred complaining of a painless tumoral mass in the left mandibular body, with several months of evolution. Previous history indicated extraction of the teeth #37 and #38 and diagnosis of chronic suppurative osteomyelitis. A deep incisional biopsy revealed CC. Due to its microscopic features, suggesting an inflammatory or reactive pro...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Adenoid cystic carcinoma: immunohistochemistry and differential diagnosis, a case report
ABSTRACT A 52-year-old male patient complained of loss of sensitivity and pain in the maxilla. After examination, root canal treatment of tooth 12 was requested. Subsequently, there was a purplish increased volume of softened consistency in the area of vestibular attached gingiva of tooth 12. The anterior upper dental segment presented mobility. Incisional biopsy revealed malignant neoplasm of glandular epithelial origin, suggestive of solid adenoid cystic carcinoma (ACC). An immunohistochemical panel was performed, which confirmed the histopathological suspicion. Solid ACC may lead to diagnostic difficulties, since this l...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

FIPLIQ: an alternative solution for gynecological and oral cytology
Conclusion: Preliminary results suggest that FIPLIQ is suitable for the preparation and preservation of cytology specimens for up to 15 days.RESUMEN Introducci ón: La citología en medio líquido fue desarrollada para mejorar la prueba de Papanicolaou. Algunos medios líquidos son comercialmente disponibles; no obstante, debido al costo elevado, hay dificultades para su implementación en programas de salud pública en muchos países. Objetivos: Estudiar la adecuación de medios líquidos alternativos para recolecta y la preservación de muestras para exámenes citológicos, comparando los resultados con la metodologí...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Histological evolution of fibrosis in patients with biliary atresia
Conclusion: Most infants with BA have liver fibrosis at diagnosis and it progresses rapidly. The presence of cirrhosis is correlated with the age at surgery, which suggests the importance of this clinical variable in the evolution of fibrosis.RESUMEN Objetivo: Analizar la evoluci ón de los hallazgos histológicos de pacientes con atresia de vías biliares (AVB), resaltando la progresión de la fibrosis y comparando la biopsia hepática diagnóstica (BHD) con la biopsia hepática quirúrgica (BHQ) mediante la hepatoportoenterostomía de Kasai. Método: Estudio retrospectivo con 51 pacientes con AB sometidos a hepatoport...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - November 11, 2019 Category: Pathology Source Type: research

Cancer registries and pathologists
This study also demonstrates that ELISA, a simple and affordable technology, can be used in routine measurement of the FoxP3 marker.RESUMEN Aunque las c élulas T reguladoras sean importantes en la regulación inmunológica de varios procesos patológicos, su papel en la inmunología de la enfermedad de Hansen, o lepra, todavía necesita ser correctamente evaluado. El objetivo de este trabajo es cuantificar el factor de transcripción nuclear P3 (Fo xP3), principal marcador de células Treg, en las diferentes formas de lepra, con y sin reacción leprosa. La expresión de células Treg fue investigada con el ensayo por inmu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 3, 2019 Category: Pathology Source Type: research

Expression of FoxP3 in different forms of leprosy and reactions
This study also demonstrates that ELISA, a simple and affordable technology, can be used in routine measurement of the FoxP3 marker.RESUMEN Aunque las c élulas T reguladoras sean importantes en la regulación inmunológica de varios procesos patológicos, su papel en la inmunología de la enfermedad de Hansen, o lepra, todavía necesita ser correctamente evaluado. El objetivo de este trabajo es cuantificar el factor de transcripción nuclear P3 (Fo xP3), principal marcador de células Treg, en las diferentes formas de lepra, con y sin reacción leprosa. La expresión de células Treg fue investigada con el ensayo por inmu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 3, 2019 Category: Pathology Source Type: research

Aggressive osteoblastoma with degeneration to secondary aneurysmal bone cyst
We report a case of aggressive osteoblastoma in which the lesion in the MRI was mimicking brain tumor or intracranial primary tumor rather than primary bone tumor.RESUMEN Paciente masculino, de 4 a ños de edad, con cefalea de 18 meses asociada a pérdida progresiva de equilibrio y dificultad de deambulación. La resonancia magnética (RM) mostró una lesión espansiva extraaxial en la porción posterior de la fosa posterior a la izquierda, comprimiendo el tejido cerebral adyacente, así como los hemisferios cerebelares; aún deforma el cuarto ventrículo con hidrocefalia obstructiva severa. La evaluación histológica dia...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 3, 2019 Category: Pathology Source Type: research

Evans syndrome in male lupus patient: case report
In this study, we present the case of a 45-year-old patient, male, who was diagnosed with ES associated with active SLE. The patient was admitted to the emergency room presenting severe hemolytic anemia and onset of thrombocytopenia. He was treated with intravenous corticosteroid therapy, followed by azathioprine.RESUMEN El s índrome de Evans (SE) es una enfermedad autoinmune rara de etiología desconocida; ocurre cuando hay combinación de anemia hemolítica autoinmune (AHAI) con trombocitopenia, acompañada o no de neutropenia inmune. Ese síndrome es un tipo variable especial de AHAI por anticuerpos calientes que pue d...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 3, 2019 Category: Pathology Source Type: research