Jornal Brasileiro de Patologia e Medicina Laboratorial This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Parotid follicular lymphoid hyperplasia - a rare entity: the challenges in differential diagnosis
ABSTRACT A 61-year-old female patient presented a nodular lesion located in the right buccal mucosa with a 3-month evolution. Clinical hypotheses of salivary duct cyst and mucocele were proposed, and the patient underwent excisional biopsy. Microscopically, a well-circumscribed and encapsulated lymphoid aggregate fragment was observed, characterized by layers of well-differentiated small lymphocytes and collections of reactive lymphoblasts. These findings, associated with immunohistochemistry, established the diagnosis of follicular lymphoid hyperplasia. Currently, the patient is well, under follow-up after six months.RESU...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Clinical-pathological aspects of oral lymphoepithelial cyst: case report
ABSTRACT Oral lymphoepithelial cyst (OLEC) is an uncommon lesion whose pathogenesis remains poorly understood. The purpose of this paper is to report a case of OLEC. Female patient, white, 62 years old, presented asymptomatic nodular swelling of soft consistency in the lateral border of the tongue. Under the clinical hypothesis of lymphoid tissue hyperplasia, an excisional biopsy was performed. Histopathological examination revealed a pathological epithelial-lined cavity and a cystic connective tissue capsule containing lymphoid tissue. The diagnosis of OLEC was established and the patient showed no signs of recurrence aft...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Eosinophilic granuloma: an unusual finding in adults
ABSTRACT A 45-year-old man presents with occipital headache for about one month, resistant to analgesic therapy, and palpable nodule at the pain site. At initial evaluation, the nodule was 1.5 cm in diameter without apparent skin alteration. Ultrasonography revealed a well-defined osteolytic lesion and doubtful communication with the dura mater. The study was complemented with computed tomography and contrast-enhanced magnetic resonance, both identifying lytic lesion with soft tissue component and contrast enhancement, without diffusion restriction, guiding the diagnostic hypothesis of eosinophilic granuloma. Surgical trea...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Statistical association of rs2243250 polymorphism of IL4 gene and hemorrhagic stroke in Brazilian population
This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients.RESUMEN La interleucina-4 (IL-4) tiene gran importancia en los procesos inflamatorios en casos de accidente cerebrovascular (ACV), puesto que hace que las microgl ías sean polarizadas hacia el fe...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Interference of blood storage containing K2EDTA and K3EDTA anticoagulants in the automated analysis of the hemogram
Conclusion: At room temperature, the parameters mean corpuscular volume (MCV), mean corpuscular hemoglo bin concentration (MCHC), and hematocrit presented significant statistical differences.RESUMEN Introducci ón: Este trabajo evaluó los posibles cambios en diferentes parámetros del hemograma, como conteo de eritrocitos totales, leucocitos, hematocrito y plaquetas, con respecto a diferentes tiempos de almacenamiento de la muestra en ambiente refrigerado y temperatura ambiente en cuanto a los efectos d e los anticoagulantes, que pueden afectar los resultados del análisis de laboratorio. Objetivo: Comparar los cambi...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Validation of a new method for estimating low platelet counts: G&S method
Conclusion: The G&S method is inexpensive, easy to perform, and has demonstrated statistical reliability concerning the automated methodology, and is useful for confirming low platelet counts after a suspected error by the automated equipment or when this device is not available for use.RESUMEN Introducci ón: Los analizadores automáticos hematológicos son capaces de realizar bajos recuentos de plaquetas con precisión y exactitud. Sin embargo, eses analizadores pueden producir recuentos erróneos debido a la presencia de interferencias. Así, métodos adicionales son necesarios para confirmar los recuentos de pl...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Nonconformities in the pre-analytical phase identified in a public health laboratory
Conclusion: Data indicate the need to strengthen training and improve the pre-analytical process in order to ensure patient safety and e pidemiological data.RESUMEN Introducci ón: Las no conformidades detectadas en la fase preanalítica de las pruebas enviadas a los laboratorios centrales (Lacen) del estado culminan en pérdida de datos epidemiológicos de gran importancia para la salud pública, además de perjudicar la vigilancia en salud. Objetivos: Este estudio inte ntó identificar las no conformidades preanalíticas más frecuentes registradas por el Lacen/PR y las mayores dificultades encontradas por unidades pr...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Meningiomas and the tumor microenvironment: expression of PD-L1 and expression of PD-L1 and interferon-gamma in the prognosis
Conclusion: IFN- γ immunoexpression was related to lower rates of tumor recurrence and longer progression-free survival time; there was also a relationship with the absence of pleomorphism, better differentiation and lower tumor grade for this marker.RESUMEN Introducci ón: Los meningiomas son los tumores intracraneales más comunes en personas adultas. Uno de los mecanismos utilizados por células tumorales para escapar de la muerte es interferir con los puntos de control inmunológicos, impidiendo así el establecimiento de una respuesta inmunitaria adecuada. S iguiendo este concepto, un objetivo prometedor para una...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Incidence of Chlamydia trachomatis detected by PCR in women's endocervical samples in Lages, Santa Catarina, Brazil
Conclusion: The incidence of C. trachomatis infection in the endocervical samples from these women can be considered high, which emphasizes the importance of measures designed to clarify and prevent this important STI.RESUMEN Introducci ón: Chlamydia trachomatis es uno de los principales agentes causantes de infecciones de transmisión sexual (ITS) en hombres y mujeres, pero el mayor impacto de la infección se produce en el aparato reproductor de las mujeres, causando, entre otros problemas, infertilidad. Objetivo: Calcular la incidencia de C. trachomatis detectada por la técnica de reacción en cadena de la polim...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Laboratory medicine resilience during coronavirus disease 2019 (Covid-19) pandemic
(Source: Jornal Brasileiro de Patologia e Medicina Laboratorial)
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

First report of hemosiderotic adenodermatofibroma in Brazil
We present the first case report of this entity in Brazil together with representative images, in addition to a review on the subject and discussion about the apocrine origin of this lesion.RESUMEN El dermatoadenofibroma hemosider ótico es una lesión recientemente descrita, caracterizada por un nódulo dérmico con estructuras quísticas de una glándula apocrina, rodeado por un estroma del tipo dermatofibroma con macrófagos hemosideróticos. Presentamos el primer reporte de caso de esa entidad en Brasil, junto a imágenes representativas, además de una revisión del tema y discusiones acerca del origen apocrina de es...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Granular cell tumor in female neonate: a case report
ABSTRACT The granular cell tumor (GCT) is a neoplasm of connective tissue which rarely occurs in children. This case report aims to describe and discuss the presentation of this tumor in a female neonate. Compared to previous literature, the case report demonstrated a rare form of presentation of this tumor in an unusual age group.RESUMEN O tumor de c élulas granulares (TCG) é uma neoplasia de tecido conjuntivo que ocorre raramente em crianças. Este relato de caso descreve e discute a apresentação desse tumor em um neonato do sexo feminino. Em comparação com estudos anteriores, o caso reportado demonstrou uma forma ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
ABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Flu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Mucoepidermoid carcinoma of the retromolar region: case report
ABSTRACT The present study aimed to report a case of mucoepidermoid carcinoma (MEC), focusing on its clinical-pathological characteristics. At intraoral clinical examination, a nodular lesion was observed in the right pterygomandibular raphe region, with three years of evolution. An incisional biopsy was performed, and the diagnostic hypotheses of salivary gland injury and sialadenitis were considered. Histopathologically, a malignant neoplastic process characterized by the proliferation of epidermoid, intermediate and mucosal cells was observed. The histopathological diagnosis of MEC was emitted. The present case praises ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

The value of fasting in the diagnosis of medium-chain acyl-CoA dehydrogenase deficiency
ABSTRACT Female patient carrier of medium-chain acyl-CoA dehydrogenase deficiency (MCADD) with recurrent clinical episodes of hypoglycemia and altered level of consciousness, presented changes in blood acylcarnitine profile by tandem mass spectrometry and in the urinary organic acid analysis by gas chromatography/mass spectrometry (GC/MS). This case demonstrates the importance of fasting prior biological sample collection (when possible) when MCADD is suspected, and emphasizes that the time/momentum of biological sample collection is crucial to diagnosis, considering the possibility that MCADD is underdiagnosed in Brazil.R...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research