Jornal Brasileiro de Patologia e Medicina Laboratorial 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Histopathological profile of patients diagnosed with malignant tumors assisted in a hospital of reference of Agreste Pernambucano
ABSTRACT Cancer is considered a public health problem and is commonly known because of its high mortality rate worldwide. The histopathological evaluation is a fundamental requirement to determine the nature of the lesion, thus it is considered the gold standard examination for diagnosis of neoplasia. The present study aims to evaluate the histopathological profile of patients with malignant tumors diagnosed at a reference hospital in the Agreste Pernambucano. A cross-sectional, descriptive study of a quantitative documentary survey was conducted using the database of the clinical analysis laboratory of the referred Hospit...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research
Comparative analysis of the histopathological and epidemiological profile of ductal and lobular breast carcinomas diagnosed at the Hospital de ClÃnicas da Universidade Federal do Paraná during the period 2008-2013
Conclusion: The breast carcinomas evaluated in this study presented a profile similar to that reported in the literature, with some peculiarities inherent to the local pathology service. Nevertheless, the low frequency of in situ cases indicates failure in early diagnosis.RESUMEN Introducci ón: El cáncer de mama es la segunda causa de muerte por cáncer entre mujeres alrededor del mundo, y estudios epidemiológicospueden contribuir al entendimiento de sus mecanismos. Objetivos: Determinar el número de casos de carcinoma de mama diagnosticados en un perÃodo de seis anos. Método: El perfil de los carcinomas de mama ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research
Validation of chromogenic in situ hybridization reactions for DNA and RNA detection in formalin-fixed paraffin-embedded tissue
The objective of this study was to validate the deoxyribonucleic acid (DNA) (+) and (-), and ribonucleic acid (RNA) (+) and (-) control probes to be used as quality control for the samples, evaluating preservation of the genetic material. Materials and methods: Twelve histological sections were used (in quadruplicate, n = 48), prepared from a pool of tissues without microscopic changes related to infectious and/or inflammatory processes. The CISH protocol was conducted according to the manufacturer ’ s instructions, standardized under the conditions of our laboratory, using commercial DNA and RNA probes chemically linke...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research
Comparative evaluation of the quality of Papanicolaou staining at different intervals of fixation times using 96% ethyl alcohol
Conclusion: The results suggest that there is a significant difference in the staining quality (p-value = 0.01) according to the fixation time.RESUMEN Introducci ón: La fijación de extensiones citológicas consiste en la inmersión inmediata en fijador adecuado para preservar la morfologÃa celular, siendo esencial para el análisis microscópico y la interpretación diagnóstica. Objetivo: Evaluar la influencia de los tiempos de fijación en las caracter Ãsticas morfológicasy de tinción de muestras fijadas con metanoly tenidas con el método de Papanicolaou. Método: Se realizó una investigación experimental, cu...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research
Profile of women with cervical changes from a city in the Northeast Brazil
Conclusion: Women infected by Gardnerella vaginalis and older than 30 years of age are more exposed to the development of alterations. Guidelines on prevention and screening should be continuous strategies in public services. Understanding these risk factors is a paramount concern because they are involved in the prevention and etiology process of cervical lesions and cancer.RESUMEN Introducci ón: En Brasil, el cáncer de cuello de útero es la cuarta causa de muertepor cáncer, con 5.430 muertes en 2013 y previsión de 16.370 nuevos casos para 2018. Su aparición se asocia a la infección previa por el virus delpapiloma...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research
Peritoneal washing in gynecological neoplasias
Conclusion: The prevalence of peritoneal lavage cytology positive for malignancy was 7% in endometrial adenocarcinoma and 20% in ovarian adenocarcinoma. Only the degree of tumor differentiation of ovarian adenocarcinomas showed a significant association with peritoneal washing positivity.RESUMEN Introducci ón y objetivo: La citologÃa del lavadoperitoneal es parte de la estadificación de los adenocarcinomas de endometrio y ovario. El objetivo de este trabajo es estimar la prevalencia de citologÃas positivas para malignidad en pacientes con diagnóstico de adenocarcinoma de endometrio y/u ovario, as à como la asociaciÃ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research
Evaluation of the clinicai analysis service provided to an emergency department
Conclusion: The results show several opportunities for progress in the relationship between ED and CAS. The improvement of laboratory quality indicators also depends on the involvement of ED physicians and nurses and embraces monitoring, planning, education and investment in system computerization.RESUMEN Introducci ón: El tiempo de entrega de pruebas y la comunicación de valores crÃticos por el laboratorio clÃnico son considerados factores determinantes del tiempo de permanencia del paciente en la Sección de Urgencias (SU). Por lo tanto, asà como la satisfacción de los médicos, estos datos también son utilizado...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 14, 2019 Category: Pathology Source Type: research
Cancer: but what if it were a disease caused by an association between microorganisms?
This article makes an analogy and compares the biological behavior of bacteria, viruses and neoplasms, showing several common points in their mechanisms of growth and survival, questioning cancer as a distinct living organism and introducing the hypothesis of synergy between viruses and bacteria in the development of neoplasms. Up to now, there are no experimental studies that effectively investigate the association between more than one microorganism as an etiologic factor of cancer.RESUMO Apesar dos avan ços no conhecimento do comportamento das neoplasias, o entendimento exato dos processos biológicos que envolvem os t...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
Investigation of correlation between cytological and histological findings in suspected carcinoma of thyroid
Conclusion: The prevalence of Bethesda II category was lower than predicted by TBSRTC (60%-70%), as well as Bethesda III was higher than recommended (7%). Nevertheless, the corresponding malignancy rates were within the expected ranges.RESUMO Introdu ção: A classificação citopatológica tireoidiana com base no Sistema de Bethesda para Relatos de Citopatologia da Tireoide (SBRCT) padronizou os resultados provenientes de punção aspirativa por agulha fina (PAAF). Seu uso tem facilitado a comunicação entre clÃnicos, parece reduzir o número de tireoidectomias não necessárias e também melhora a qualidade na detecÃ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
Patient safety by analyzing the information not provided in the requisition orders of cervical cytology test
Conclusion: There is a need for professional training about filling in the information on requis itions, because they collaborate with the increase of the sensitivity and specificity of the cytology test, thus allowing more reliable results that aid in patient safety.RESUMO Introdu ção: O câncer do colo do útero é um sério problema de saúde pública devido a sua alta incidência e mortalidade em paÃses subdesenvolvidos, sendo, desta forma, uma prioridade na saúde mundial. Programas organizados de rastreamento podem reduzir a incidência e a mortalidade do câncer do c olo do útero em virtude da detecção precoc...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
Detection of sexually transmitted infections at a Brazilian gynecology center: high prevalence of co-infections
Conclusion: Since most of the women analyzed were affected by more than one STI, our results suggest that routine screening for these infections at health centers would help in early detection, treatment and prevention of these infections. These measures would also impact on patients ’ cervical cancer control.RESUMO Introdu ção: As infecções sexualmente transmissÃveis (ISTs) ainda são um importante problema de saúde pública, e a vigilância é essencial para sua prevenção e seu controle. Objetivo: Avaliar a prevalência das ISTs em uma unidade de referência ginecológica no Rio de Janeiro, Brasil. Materiai...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
Turner syndrome and spontaneous pregnancy
The objective of this study is to describe patients with Turner syndrome (TS) who had spontaneous pregnancy and, when possible, to present the frequency of this outcome in this genetic condition. This is a literature review conducted in MedLine/PubMed, using the following English descriptors: Turner syndrome and spontaneous pregnancy. The following filters have been activated: articles with a publication date from the last 10 years that present the descriptors in the title/abstract. Twenty-nine articles were identified using the electronic search. After applying the inclusion and exclusion criteria, the number of articles ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
Thrombomodulin and interleukin 6 as potential biomarkers of endothelial dysfunction and inflammation after renal transplant
Conclusion: TM and IL-6 can be identified as potential markers for evaluating renal graft function. TM was more related to the primary cause of CKD compared to vWF and IL-6.RESUMO Introdu ção: A disfunção endotelial pode contribuir para estados de hipercoagulabilidade e inflamação presentes no transplante renal e na doença renal crônica (DRC) e suas causas, podendo ser avaliada por marcadores como trombomodulina (TM), fator de von Willebrand (FvW) e interleucina 6 (IL-6). Ob jetivos: Avaliar TM, FvW e IL-6 em receptores do transplante renal (RTR) e associar seus nÃveis com a causa primária de DRC pré-transplan...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
Hsp27 expression and ratio between cell proliferation rate and apoptosis in breast cancer with and without axillary metastases
Conclusion: Quantitative analysis of Hsp27 demonstrated increased protein expression in primary neoplasm tissues and in lymph nodes in carcinomas without axillary sentinel lymph node metastasis. Although the methodology and the number of cases do not allow concluding that this behavior in metastatic disease is a constant finding, this justifies the need to evaluate this finding in future studies.RESUMO Introdu ção: O envolvimento do sistema imunológico no processo de neoplasias vem sendo cada vez mais estudado devido ao seu potencial em terapia antitumorais. Objetivos: Avaliar a expressão de heat shock protein 27 (H...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
Performance of rapid tests compared to conventional tests used for HIV diagnosis
ABSTRACT Introduction: Early diagnosis is an important tool for strategies to fight human immunodeficiency virus (HIV) infection. Objective: The main objective of this study is to evaluate the comparability of the results of rapid tests (RT) used for the HIV diagnosis in relation to conventional molecular and serological tests in blood samples from a population of men who have sex with men (MSM), from 12 Brazilian capitals. Material and methods: 591 HIV-1 reactive test samples from 4176 MSM participants were submitted to Instituto Adolfo Lutz (IAL) for evaluation by conventional laboratory tests. From these samples with...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - January 10, 2019 Category: Pathology Source Type: research
