Adverse consequences of low-dose methotrexate medication errors: data from French Poison Control and Pharmacovigilance Centers
ConclusionsThis study confirms that dosing errors with methotrexate can be lethal and persisted despite several warnings from drug agencies. Further measures are awaited from the European Medicine Agency. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 21, 2018 Category: Orthopaedics Source Type: research

Recommendations for the assessment and optimization of adherence to disease-modifying drugs in chronic inflammatory rheumatic diseases: a process based on literature reviews and expert consensus
ConclusionsUsing an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 21, 2018 Category: Orthopaedics Source Type: research

Circadian rhythms and rheumatoid arthritis
Publication date: Available online 15 September 2018Source: Joint Bone SpineAuthor(s): Cutolo MaurizioAbstractCircadian rhythms (Nobel prize for Medicine 2017) regulate, under action of biological clocks located both at the level of central nervous system and inside peripheral cells, several daily activities, embracing sleep, feeding times, energy metabolism, endocrine and immune functions with related pathological conditions, including rheumatoid arthritis (RA).In RA the circadian rhythms impact on cellular functions, involving night synthesis and release of proinflammatory cytokines and chemokines, cell migration to infl...
Source: Joint Bone Spine - September 16, 2018 Category: Orthopaedics Source Type: research

Targeted Immunotherapy Strategies in ANCA-Associated Vasculitis
This article reviews the current role for targeted immunotherapy in AAV, its validated indications, and avenues for further development. Rituximab is a validated induction treatment for GPA and severe MPA. Rituximab in these indications is not less effective than cyclophosphamide and is particularly useful in patients with refractory or relapsing disease, women of childbearing potential, and patients previously treated with cyclophosphamide. Rituximab is more effective than cyclophosphamide for treating relapses. For remission maintenance therapy, which is indispensable, rituximab has been proven superior over conventional...
Source: Joint Bone Spine - September 8, 2018 Category: Orthopaedics Source Type: research

Hip Disease Complicating Myelitis
Publication date: Available online 7 September 2018Source: Joint Bone SpineAuthor(s): Lhuillier Marine, Cormier Grégoire, André Vincent, Varin Stéphane, Caulier Michel, Tanguy Gilles, Cozic Céline (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 8, 2018 Category: Orthopaedics Source Type: research

Safety of biological agents in paediatric rheumatic diseases: a real-life multicenter retrospective study using the JIRcohorte database
ConclusionThis study suggests an overall an acceptable safety of biologic agents in children with inflammatory rheumatic diseases treated with biological agents. However, the concomitant prescription of immunosuppressive drugs with biological agents represents a substantial risk of adverse events. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 8, 2018 Category: Orthopaedics Source Type: research

Intraarticular synovial osteochondromatosis of the elbow joint with radial nerve palsy
Publication date: Available online 7 September 2018Source: Joint Bone SpineAuthor(s): Gwenaël Mevel, De Geyer, Mickaël Ropars (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 8, 2018 Category: Orthopaedics Source Type: research

Reply to the comment of Fayet et al. Obstacles and motivations to influenza and pneumococcal vaccination in patients with rheumatoid arthritis. A qualitative study
Publication date: Available online 24 July 2018Source: Joint Bone SpineAuthor(s): Manal Assala, Matthieu Groh, Philippe Blanche, Christine Vinter, Patrice Cohen, Véronique Le Guern, Xavier Puéchal, Luc Mouthon, Claire Le Jeunne, Odile Launay, Solen Kernéis (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 29, 2018 Category: Orthopaedics Source Type: research

Serum and urinary macrophage migration inhibitory factor (MIF) in primary Sjögren's syndrome
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Fabien B. Vincent, Tali Lang, Rangi Kandane-Rathnayake, Sarah Downie-Doyle, Eric F. Morand, Maureen Rischmueller (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 25, 2018 Category: Orthopaedics Source Type: research

Bone Disorders Associated with Diabetes Mellitus and Its Treatments
Publication date: Available online 8 August 2018Source: Joint Bone SpineAuthor(s): Bernard Cortet, Stéphanie Lucas, Isabelle Legroux-Gerot, Guillaume Penel, Christophe Chauveau, Julien PaccouABSTRACTBoth type 1 and type 2 diabetes mellitus are associated with bone disorders, albeit via different mechanisms. Early studies in patients with type 1 diabetes suggested a 10-fold increase in the hip fracture risk compared to nondiabetic controls. Metaanalyses published more recently indicate a somewhat smaller risk increase, with odds ratios of 6 to 7. Diminished bone mineral density is among the contributors to the increa...
Source: Joint Bone Spine - August 8, 2018 Category: Orthopaedics Source Type: research

Sarcopenia
Publication date: Available online 8 August 2018Source: Joint Bone SpineAuthor(s): Anne Tournadre, Gaelle Vial, Frédéric Capel, Martin Soubrier, Yves BoirieABSTRACTSarcopenia is defined as a combination of low muscle mass with low muscle function. The term was first used to designate the loss of muscle mass and performance associated with aging. Now, recognized causes of sarcopenia also include chronic disease, a physically inactive lifestyle, loss of mobility, and malnutrition. Sarcopenia should be differentiated from cachexia, which is characterized not only by low muscle mass but also by weight loss and an...
Source: Joint Bone Spine - August 8, 2018 Category: Orthopaedics Source Type: research

Dimethyl fumarate induced migrating polyarthralgias
Publication date: Available online 3 August 2018Source: Joint Bone SpineAuthor(s): Marc Villedon de Naide, Xavier Moisset, Martin Soubrier (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 4, 2018 Category: Orthopaedics Source Type: research

Methotrexate Mechanism in Treatment of Rheumatoid Arthritis
Publication date: Available online 3 August 2018Source: Joint Bone SpineAuthor(s): Benjamin Friedman, Bruce CronsteinAbstractMethotrexate has been used in treatment of rheumatoid arthritis (RA) since the 1980s and to this day is often the first line medication for RA treatment. In this review, we examine multiple hypotheses to explain the mechanism of methotrexate efficacy in RA. These include folate antagonism, adenosine signaling, generation of reactive oxygen species (ROS), decrease in adhesion molecules, alteration of cytokine profiles, and polyamine inhibition amongst some others. Currently, adenosine signaling is pro...
Source: Joint Bone Spine - August 4, 2018 Category: Orthopaedics Source Type: research

Rheumatoid arthritis revealed by polyadenopathy, diarrhea and digestive AA amyloidosis
Publication date: Available online 3 August 2018Source: Joint Bone SpineAuthor(s): Simon Galmiche, David Buob, Soraya Fellahi, Jean-Philippe Bastard, Gilles Grateau, Sophie Georgin-Lavialle (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 4, 2018 Category: Orthopaedics Source Type: research

Fatty acids and osteoarthritis: different types, different effects
Publication date: Available online 3 August 2018Source: Joint Bone SpineAuthor(s): Marieke Loef, J.W. Schoones, Margreet Kloppenburg, Andreea Ioan-FacsinayAbstractWhile the association between obesity and osteoarthritis used to be solely regarded as a result of increased mechanical loading, systemic factors also likely play a role in the pathophysiology of osteoarthritis. Nutrient excess leading to obesity may result in lipotoxicity, which might be involved in the development of osteoarthritis. The different fatty acid types have distinct effects on inflammation. This review focusses on the currently available studies, sum...
Source: Joint Bone Spine - August 4, 2018 Category: Orthopaedics Source Type: research

Reply to the comment of Alkan Melikoglu ‘Joint manifestations can provide diagnostic clues in Morquio syndrome, a case report’
Publication date: Available online 29 July 2018Source: Joint Bone SpineAuthor(s): Stéphane Mitrovic, Hélène Gouze, Thierry Schaeverbeke, Laure Gossec, Bruno Fautrel (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 30, 2018 Category: Orthopaedics Source Type: research

What is the best salivary gland ultrasonography scoring methods for the diagnosis of primary or secondary Sjögren’s syndromes?
Publication date: Available online 24 July 2018Source: Joint Bone SpineAuthor(s): Amélie Martel, Guillaume Coiffier, Aurore Bleuzen, Jean Goasguen, Michel de Bandt, Christophe Deligny, Julie Magnant, Nicole Ferreira, Elisabeth Diot, Aleth Perdriger, François MaillotAbstractObjectiveTo evaluate the performance of salivary gland ultrasonography for the diagnosis of primary and secondary Sjögren’s syndromes (pSS and sSS).MethodMulticenter cross-sectional study on 97 patients with clinical sicca symptoms. The pSS (n = 39) and the sSS (n = 22) met the American-European Consen...
Source: Joint Bone Spine - July 25, 2018 Category: Orthopaedics Source Type: research

The past encounters the future: “old” diagnostic methods to check innovative treatments for carpal tunnel syndrome. Comment on: “Treatment of carpal tunnel syndrome: from ultrasonography to ultrasound surgery” by Petrover et al. Joint Bone Spine 2017 10.1016/j.jbspin.2017.11.003
Publication date: Available online 24 July 2018Source: Joint Bone SpineAuthor(s): Daniele Coraci, Silvia Giovannini, Claudia Loreti, Cristiano Pecchioli, Giulia Piccinini, Luca Padua (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 25, 2018 Category: Orthopaedics Source Type: research

Replay to the comment of Fayet et al. Obstacles and motivations to influenza and pneumococcal vaccination in patients with rheumatoid arthritis. A qualitative study
Publication date: Available online 24 July 2018Source: Joint Bone SpineAuthor(s): M Assala, M Groh, P Blanche, C Vinter, P Cohen, V Le Guern, X Puéchal, L Mouthon, C Le Jeunne, O Launay, S Kernéis (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 25, 2018 Category: Orthopaedics Source Type: research

Incidence of articular pain and arthritis after chikungunya fever in The Americas: A systematic review of the literature and meta-analysis
ConclusionFifty two percent of Chikungunya infected patients in the American continent are expected to develop the chronic stage of the disease. Chikungunya fever needs to be dealt as a major world health problem. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 25, 2018 Category: Orthopaedics Source Type: research

Remission and stringent treatment goals in psoriatic arthritis: Doctors’ opinion is not enough
Publication date: Available online 3 July 2018Source: Joint Bone SpineAuthor(s): Rubén Queiro (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 19, 2018 Category: Orthopaedics Source Type: research

Association between Gout and Cardiovascular disease risk: A Nation-wide Case-Control Study
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Chia-wei Liang, Mohaimenul Islam, Tahmina Nasrin Poly, Hsuan-ChiaYang, Yu-Chuan Li Jack (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Serum and Urinary Macrophage Migration Inhibitory Factor (MIF) in Primary Sjögren’s Syndrome
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Fabien B Vincent, Tali Lang, Rangi Kandane-Rathnayake, Sarah Downie-Doyle, Eric F Morand, Maureen Rischmueller (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Is fat that bad in rheumatoid arthritis?
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Gaëlle Clavel, Johanna Sigaux, Luca Semerano (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Joint manifestations can provide diagnostic clues in Morquio syndrome. Comment on: “Mucopolysaccharidoses seen in adults in rheumatology” by Mitrovic et al, Joint Bone Spine. 2017;84:663-670
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Meltem Alkan Melikoglu (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Determinants of daily pain trajectories and relationship with pain acceptability in hip and knee osteoarthritis. A national prospective cohort study on 886 patients
ConclusionIn lower limb OA, pain is mostly stable over a 28-days period. Pain is better accepted when stable, with different determining factors according location. DPT should be considered when establishing HOA and KOA management. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Obstacles and motivations to influenza and pneumococcal vaccination in patients with rheumatoid arthritis. A qualitative study. Comment on : « Pneumococcal and influenza vaccination rates in patients treated with corticosteroids and/or immunosuppressive therapies for systemic auto-immune diseases: A cross-sectional study” by Assala et al., Joint Bone Spine. 2017;84:365-6
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Françoise Fayet, Carine Savel, Malory Rodere, Martin Soubrier, Sylvain Mathieu (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Non-pharmacologic measures for gout management in the prospective GOSPEL cohort: physicians’ practice and patients’ compliance profiles
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Anthony Chapron, Typhaine Chopin, Maxime Esvan, Ea Hang-Korng, Frédéric Lioté, Pascal GuggenbuhlAbstractObjectivesGout management includes non-pharmacological measures (NPM). The main objective of this study was to describe the NPM proposed by physicians and their implementation by patients after 3-6 months. The secondary objective was to identify NPM compliance profiles among these patients.MethodsAncillary observational study using the GOSPEL French cohort of 1003 patients with gout, based on questionnaires for physicia...
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

The popliteal groove region: a new target for the detection of monosodium urate crystal deposits in patients with gout. An ultrasound study
Publication date: Available online 17 July 2018Source: Joint Bone SpineAuthor(s): Andrea Di Matteo, Emilio Filippucci, Edoardo Cipolletta, Matteo Ausili, Victoria Martire, Marco Di Carlo, Fausto Salaffi, Walter GrassiAbstractObjectivesTo determine the prevalence of the ultrasound findings indicating monosodium urate crystal deposits at the popliteal groove region in patients with gout; to evaluate the diagnostic accuracy of ultrasound in detecting monosodium urate crystal deposits at the popliteal groove region, patellar tendon and the knee hyaline cartilage; to investigate the correlation between the ultrasound findings a...
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Serum retinol binding protein 4 is associated with insulin resistance in patients with early and untreated rheumatoid arthritis
In this study, 403 individuals with newly diagnosed and untreated RA were consecutively recruited. We calculated the Disease Activity Score assessed using 28-joint counts for swelling and tenderness (DAS28). Levels of serum RBP4, interleukin-6 (IL-6) and tumor necrosis factor (TNF) α were tested. IR was defined as Homeostasis model assessment for insulin resistance (HOMA-IR) index greater than or equal 2.40.ResultsIn those 403 patients, 68 (16.9%) were male and the median age was 43 years (IQR, 36–52). There was an evidently positive correlation between increased serum levels of RBP4 and increasing severity of ...
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Impact of comorbidities on fatigue in rheumatoid arthritis patients: results from a nurse-led program for comorbidities management (COMEDRA)
ConclusionsAssessment of comorbidities, psychological health and physical activity should be taken into account in order to address frequent RA-related severe fatigue. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 18, 2018 Category: Orthopaedics Source Type: research

Bone metastases from lung cancer: a paradigm for multidisciplinary onco-rheumatology management
Publication date: Available online 6 April 2018Source: Joint Bone SpineAuthor(s): Cyrille B. Confavreux, Jean-Baptiste Pialat, Aurélie Bellière, Marie Brevet, Chantal Decroisette, Agnès Tescaru, Julien Wegrzyn, Cédric Barrey, Françoise Mornex, Pierre-Jean Souquet, Nicolas GirardAbstractBone is the third metastatic site after liver and lungs. Bone metastases occur in one out of three lung cancers and are usually of osteolytic aspect. Osteolytic bone metastases are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely...
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Hydroxychloroquine for the prevention of fetal growth restriction and prematurity in lupus pregnancy: A systematic review and meta-analysis
ConclusionThis meta-analysis failed to prove the efficacy of HCQ in the prevention of prematurity as well as IUGR during SLE pregnancies. Due to the heterogeneity of the studies, these results should be interpreted cautiously. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Biological Agents in the Management of Adult-Onset Still's disease
Publication date: Available online 6 April 2018Source: Joint Bone SpineAuthor(s): Charlotte Girard-Guyonvarc’h, Cem Gabay (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Evaluation of bone quality with trabecular bone score in active spondyloarthritis
Publication date: Available online 6 April 2018Source: Joint Bone SpineAuthor(s): Karima Boussoualim, Adamah Amouzougan, Beatrice Pallot-Prades, Delphine Denarié, Philippe Collet, Hubert Marotte, Thierry ThomasAbstractObjectiveMany patients with spondyloarthritis (SpA) are at risk of fracture due to bone fragility, whereas their bone mineral density (BMD) is not significantly diminished. Other tools, such as trabecular bone score (TBS), evaluating other characteristics of bone tissue are therefore necessary in order to evaluate bone changes in these patients. Therefore we evaluated TBS as a bone quality marker, in a...
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Impact of obesity on the efficacy of different biologic agents in inflammatory diseases: a systematic review and meta-analysis
ConclusionObesity hampered the effect of anti-TNF agents, but not those of abatacept and tocilizumab, suggesting that a personalized treatment strategy should be considered for obese patients with inflammatory diseases. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Camptocormia with trigeminal involvement revealing myositis with anti-Ku antibodies
Publication date: Available online 10 April 2018Source: Joint Bone SpineAuthor(s): Sébastien De Almeida Chaves, Guillaume Moulis, Gregory Pugnet, Laurent Sailler, Léonardo Astudillo (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Adipokines and bone status in a cohort of anorexic patients
ConclusionBone status in anorexia nervosa is mainly determined by BMI, leptin and adiponectin. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

A 3-year back and forth between Modic type 1 and 2 on MRI in chronic low back pain
Publication date: Available online 11 April 2018Source: Joint Bone SpineAuthor(s): A. Amouzougan, K. Boussoualim, H. Marotte, F.G. Barral, T. Thomas (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

2018 update of French recommendations on the management of postmenopausal osteoporosis
Discussion and conclusionThe updated recommendations place strong emphasis on the treatment of women with severe fractures, in whom the use of osteoporosis medications is recommended. All the available osteoporosis medications are suitable in patients with severe fractures; zoledronic acid deserves preference as the fist-line drug after a hip fracture. In patients with or without non-severe fractures, the decision to use osteoporosis medications is based on bone mineral density values and in challenging cases, on probabilities supplied by prediction tools such as FRAX®. All osteoporosis medications are suitable; raloxi...
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Effectiveness and safety of anakinra in gout patients with stage 4–5 chronic kidney disease or kidney transplantation: A multicentre, retrospective study
ConclusionAnakinra may be a safe therapeutic option for gout patients with advanced CKD. Further randomized controlled studies are required to confirm our results. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Dropped head syndrome with proximal myopathy revealing AL amyloidosis
Publication date: Available online 11 April 2018Source: Joint Bone SpineAuthor(s): Charlotte Laurent, Jessie Aouizerate, Alexia Hourdille, Emmanuel Itti, François-Jérôme Authier, Xavier Chevalier (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Gut microbiome and bone
Publication date: Available online 11 April 2018Source: Joint Bone SpineAuthor(s): Lidia Ibáñez, Matthieu Rouleau, Abdelilah Wakkach, Claudine Blin-WakkachAbstractThe gut microbiome is now viewed as a tissue that interacts bidirectionally with the gastrointestinal, immune, endocrine and nervous systems, affecting the cellular responses in numerous organs. Evidence is accumulating of gut microbiome involvement in a growing number of pathophysiological processes, many of which are linked to inflammatory responses. More specifically, data acquired over the last decade point to effects of the gut microbiome on bo...
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Diagnostic contribution of HLA-A,B,C,DR genotyping in inflammatory joint disease
Publication date: Available online 11 April 2018Source: Joint Bone SpineAuthor(s): Jean Roudier, Emmanuel Massy, Nathalie Balandraud (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Relevance and feasibility of a systematic screening of multimorbidities in patients with chronic inflammatory rheumatic diseases
ConclusionThis study underlines the relevance of a systematic screening of multimorbidities in chronic inflammatory rheumatic diseases and its feasibility in a 1-day clinic. Spirometry and sleep apnea screening should be added to EULAR points to consider. The long-term impact of such screening needs to be evaluated. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Anti PAD autoimmunity and rheumatoid arthritis
Publication date: Available online 12 April 2018Source: Joint Bone SpineAuthor(s): Jean Roudier, Nathalie Balandraud, Isabelle Auger (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Impact of ACR 2010 fibromyalgia criteria fulfillment on disease activity evaluation in patients with axial spondyloarthritis treated with infliximab
Publication date: Available online 20 April 2018Source: Joint Bone SpineAuthor(s): Alexandra Dantu, Julien Michaud, Quentin Bréhier, Christopher Banse, Gilles Avenel, Thierry Lequerré, Sophie Pouplin, Olivier Vittecoq, Mathieu Verdet (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Non-infective endocarditis: Expanding the phenotype of giant cell arteritis
Publication date: Available online 27 April 2018Source: Joint Bone SpineAuthor(s): Alexandre Terré, Olivier Lidove, Odette Georges, Patrick Mesnildrey, Hélène Chennebault, Jean-Marc Ziza (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

Burden of severe spondyloarthritis in France: A nationwide assessment of prevalence, associated comorbidities and cost
ConclusionsThe burden of severe SpA in France is substantial, due to the high prevalence, high direct costs and associated comorbidities. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research

IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis
In this study, we aimed to validate this new IMSYC by studying its diagnostic performances in a well-defined collection of synovial samples.MethodsSynovial samples from patients were obtained during surgical procedures. CD68, CD3, CD20, CD31 and KI67 immunohistochemistry were performed.ResultsIn total, 77 patients were included. In total, 45 were females, mean age was 63.1 years. Forty had inflammatory arthritis, mainly rheumatoid arthritis (31/40). Non inflammatory arthritis group included 35 patients with mainly osteoarthritis. Mean Krenn score and IMSYC were significantly higher in the inflammatory group (P 
Source: Joint Bone Spine - July 11, 2018 Category: Orthopaedics Source Type: research