Epigenetics of Bone Disease
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Laetitia Michou Histone deacetylation, DNA methylation, and micro-RNAs (miRNAs) are the three main epigenetic mechanisms that regulate gene expression. All the physiological processes involved in bone remodeling are tightly regulated by epigenetic factors. This review discusses the main epigenetic modifications seen in tumoral and nontumoral bone diseases, with emphasis on miRNAs. The role for epigenetic modifications of gene expression in the most common bone diseases is illustrated by drawing on the latest publications in the field. I...
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Lessons learned from Rheumatoid Arthritis registries
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Axel Finckh, Delphine Couvoisier (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Teriparatide treatment in an adult patient with hypophosphatasia exposed to bisphosphonate and revealed by bilateral atypical fractures.
We report the case of a 67-year-old female with osteoporosis treated by alendronate during ten years.Radiographies showed atypical femoral fractures. Serum levels of total and bone-specific alkaline phosphatase were low. In order to accelerate bone healing, teriparatide was introduced. After one year of teriparatide treatment, pain and functional difficulty have decreased, and alkaline phosphatase levels were normalised. In view of this history of recurrent fractures, of atypical femoral fractures, of early spontaneous loss of teeth, and of low serum total and bone-specific alkaline phosphatase levels, the diagnosis of hyp...
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

The impact of smoking on rheumatoid arthritis outcomes
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Olivier Vittecoq, Laetitia Richard, Christopher Banse, Thierry Lequerré (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Controversies in rheumatoid arthritis glucocorticoid therapy
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Adeline Ruyssen-Witrand, Arnaud Constantin Despite therapeutic innovations in the past 20 years, glucocorticoids (GC) are still widely used for the symptomatic treatment of rheumatoid arthritis (RA). Studies have demonstrated the clinical and structural efficacy of moderate doses (i.e. 30-60 mg/d) GC in addition to disease modifying anti-rheumatic drug (DMARD) initiation in early RA. A combination of a low dose of GC (i.e. 7.5-10 mg/d) and DMARDs increases remission rates and decreases the risk of medium-term structural progre...
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Enthesopathy in rheumatoid arthritis and spondyloarthritis: an ultrasound study
Conclusions RA and SpA patients did not differ in entheseal abnormalities seen on US. Such US features may have low specificity in inflammatory conditions affecting joints and enthesis such as SpA and RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 10, 2017 Category: Orthopaedics Source Type: research

A case of Multiple Myeloma presenting with diffuse osteosclerosis and multiple bone infarcts
Publication date: Available online 9 December 2017 Source:Joint Bone Spine Author(s): Marguerite Vignon, Noémie Senot, Valérie Bousson, Véronique Meignin, Aline Frazier, Bertrand Arnulf (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 10, 2017 Category: Orthopaedics Source Type: research

Treatment of carpal tunnel syndrome : from ultrasonography to ultrasound guided carpal tunnel release
Publication date: Available online 16 November 2017 Source:Joint Bone Spine Author(s): David Petrover, Pascal Richette Carpal tunnel syndrome is the most common nerve entrapment syndrome. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. It is diagnosed clinically, often being confirmed by an electromyogram, while ultrasonography criteria have become increasingly useful for the diagnosis. Ultrasonography is better tolerated, less expensive, yet just as effective as other diagnostic methods. It provides a good indication of the severity of the condition and it allows anatom...
Source: Joint Bone Spine - December 9, 2017 Category: Orthopaedics Source Type: research

Remaining localsubclinical joint inflammation is associated with deteriorated metacarpeal head bone microarchitecture in rheumatoid arthritis patients low disease activity
Conclusion In RA patients in low disease activity under bDMARDs, persistence of local inflammation was associated with alteration of the trabecular compartment. Trabecular density was the most strongly altered parameter and could be a candidate to assess drug effect on periarticular bone damage. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 2, 2017 Category: Orthopaedics Source Type: research

A typical juxtaarticular form of Dercum's disease in a patient treated with tocilizumab for rheumatoid arthritis
Publication date: Available online 2 December 2017 Source:Joint Bone Spine Author(s): Pauline Baudart, Johann Cesini, Christian Marcelli (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 2, 2017 Category: Orthopaedics Source Type: research

Perihepatitis at the onset of Beh çet's disease: a case report
Publication date: Available online 2 December 2017 Source:Joint Bone Spine Author(s): Hirotaka Tsuno, Atsushi Hashimoto, Koichiro Horie, Akiko Komiya, Toshihiro Matsui, Shigeto Tohma (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 2, 2017 Category: Orthopaedics Source Type: research

Spondyloarthritis features in zymosan-induced SKG mice
Conclusions Zymosan-induced SKG mice developed articular and extra-articular features as well as molecular changes that resembled those of human SpA. These findings suggest that the zymosan-induced SKG mouse is a good animal model to reflect the complex features of human SpA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 1, 2017 Category: Orthopaedics Source Type: research

Promoting the consumption of dairy products for fracture prevention: a good value for money?
Publication date: Available online 29 November 2017 Source:Joint Bone Spine Author(s): Mickael Hiligsmann, Patrice Fardellone, Jean-Yves Reginster (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 1, 2017 Category: Orthopaedics Source Type: research

Calcific tendonitis of the rotator cuff: from formation to resorption
Publication date: Available online 28 November 2017 Source:Joint Bone Spine Author(s): Christelle Darrieutort-Laffite, Frédéric Blanchard, Benoit Le Goff Calcific tendonitis of the rotator cuff is due to apatite deposits in the shoulder tendons. Patients affected by calcific tendonitis have chronic shoulder pain and disability. Although the disease is frequent, about 10 to 42% of painful shoulders, mechanisms leading to this pathological mineralization are still largely unknown. Research reported in the 90s suggested that the formation of calcific deposits is linked to cells looking like chondrocytes identif...
Source: Joint Bone Spine - November 29, 2017 Category: Orthopaedics Source Type: research

Anti-citrullinated peptides antibodies in systemic sclerosis: meta-analysis of frequency and meaning
Conclusions The prevalence of ACPA in scleroderma is 9.2%. Our meta-analysis shows an increased risk for erosive arthritis, pulmonary fibrosis, oesophagus involvement and diffuse skin involvement, in patients with ACPA-positive SSc. ACPA should be systematically included in SSc assessment. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 27, 2017 Category: Orthopaedics Source Type: research

Risk of autism spectrum disorder in children born to mothers with systemic lupus erythematosus and rheumatoid arthritis in Taiwan
Conclusions Children born to women with systemic lupus erythematosus or rheumatoid arthritis do not have a higher risk of autism spectrum disorder. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 27, 2017 Category: Orthopaedics Source Type: research

Bilateral striopallidodentate calcinosis associated with Sj ögren's syndrome and IgDλ monoclonal gammopathy of undetermined significance
We presented the first case of bilateral striopallidodentate calcinosis secondary to Sjögren's syndrome. Further consideration should be given to the association between Sjögren's syndrome and bilateral striopallidodentate calcinosis, because Sjögren's syndrome is latent, but more frequent than other autoimmune diseases. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 27, 2017 Category: Orthopaedics Source Type: research

Sciatica Due to Hydroxyapatite Deposition Disease
Publication date: Available online 22 November 2017 Source:Joint Bone Spine Author(s): Charlotte de Charry, Clément Derkenne, Sophie Morelon (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 23, 2017 Category: Orthopaedics Source Type: research

Treatment Strategies for Psoriatic Arthritis
The objectives of this review are to discuss new concepts, to describe and assess the new drug classes introduced for psoriatic arthritis and, whenever possible, to define the specific indications of each class based on the rheumatic disease phenotype and presence of extraarticular manifestations. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 22, 2017 Category: Orthopaedics Source Type: research

Small Fiber Neuropathy: Diagnosis, Causes, and Treatment
Publication date: Available online 16 November 2017 Source:Joint Bone Spine Author(s): Damien Sène Small fiber neuropathy, which affects the sensory A≏ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. To help achieve this goal, the pres...
Source: Joint Bone Spine - November 17, 2017 Category: Orthopaedics Source Type: research

Treatment of carpal tunnel syndrome: from ultrasonography to ultrasound surgery
Publication date: Available online 16 November 2017 Source:Joint Bone Spine Author(s): David Petrover, Pascal Richette Carpal tunnel syndrome is the most common nerve entrapment syndrome. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. It is diagnosed clinically, often being confirmed by an electromyogram, while ultrasonography criteria have become increasingly useful for the diagnosis. Ultrasonography is better tolerated, less expensive, yet just as effective as other diagnostic methods. It provides a good indication of the severity of the condition and it allows anatom...
Source: Joint Bone Spine - November 17, 2017 Category: Orthopaedics Source Type: research

Switching from originator infliximab to biosimilar CT-P13 in real-life: the weight of patient acceptance
Conclusions Retention rate was lower after switching from OI to CT-P13 compared to our control cohorts. However, this difference faded after excluding patients without objective clinical activity, suggesting a reluctance of patients to the switch and a negative perception of the biosimilar. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 15, 2017 Category: Orthopaedics Source Type: research

Vertebral marrow adipose tissue adipokines as a possible cause of intervertebral disc inflammation
Publication date: Available online 5 October 2017 Source:Joint Bone Spine Author(s): Zvonimir Vrselja, Goran Curic (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 14, 2017 Category: Orthopaedics Source Type: research

Correlation between catastrophizing and Lequesne index in case of osteoarthritis of the knee: a prospective study
Conclusion psychological factors like catastrophizing correlated with Lequesne index. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 1, 2017 Category: Orthopaedics Source Type: research

Bone sarcoidosis
Publication date: Available online 28 October 2017 Source:Joint Bone Spine Author(s): Agathe Farge, Pauline Baudart, Sarah Jafari, Christian Marcelli (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 29, 2017 Category: Orthopaedics Source Type: research

High prevalence of sacrococcygeal pilonidal sinus disease in patients with ankylosing spondylitis
Publication date: Available online 13 October 2017 Source:Joint Bone Spine Author(s): Mehmet Soy, Pamir Atagündüz, Cemal Bes, Aysun Aksoy, Ozan Kocakaya (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 14, 2017 Category: Orthopaedics Source Type: research

Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial
Conclusion Among patients with knee OA, statin use was associated with radiological worsening over 3 years, regardless of other potential confounding factors (obesity, type 2 diabetes, hypertension, disease duration, symptom intensity and radiological severity). (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 14, 2017 Category: Orthopaedics Source Type: research

Economic analysis of a nurse-led programme for comorbidities management of rheumatoid arthritis patients
Conclusions From the hospital's perspective and from both a medical and economic point of view, a nurse-led programme to manage the comorbidities of RA is useful. (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 5, 2017 Category: Orthopaedics Source Type: research

Spinal fracture in diffuse idiopathic skeletal hyperostosis
Publication date: Available online 3 October 2017 Source:Joint Bone Spine Author(s): Rachid Redjati, Richard Damade, Valerie Royant (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 4, 2017 Category: Orthopaedics Source Type: research

Giant cell tumor of bone under Denosumab treatment
Publication date: Available online 29 September 2017 Source:Joint Bone Spine Author(s): Daniel Wendling, Xavier Guillot, Maxime Sondag, Loic Chaigneau, Sébastien Aubry, Clément Prati (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 30, 2017 Category: Orthopaedics Source Type: research

Temporomandibular joint  involvement in ankylosing spondylitis
Publication date: Available online 29 September 2017 Source:Joint Bone Spine Author(s): Faten Frikha, Mouna Snoussi, Sondes Briki, Fathi Karray, Zouhir Bahloul (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 30, 2017 Category: Orthopaedics Source Type: research

Building a transitional care checklist in rheumatology: a Delphi-like survey
Conclusions This Delphi-like study defined what themes should be included and at what age they need to be addressed with patients with a chronic rheumatology disease and their families during transition. This checklist reached a strong international and interdisciplinary consensus while examining transition in a broad way. It should now be spread widely to health professionals to be used by all those who care for adolescents aged ≥12 years at times of transition. It could be transposed to most chronic conditions. Recommendations for further research are given. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 29, 2017 Category: Orthopaedics Source Type: research

Impaired Intracellular Pathogen Clearance and Inflammatory Joint Disease: Is Whipple's Disease a Guiding Light?
Publication date: Available online 28 September 2017 Source:Joint Bone Spine Author(s): Jean-Marie Berthelot, Xavier Puéchal Whipple's disease can mimic spondyloarthritis (SpA) or rheumatoid arthritis (RA) for many years and, in a few cases, induces the development of antibodies to cyclic citrullinated peptides. The causative agent Tropheryma whipplei can smolder within cells, including macrophages, by suppressing the xenophagic process, a type of selective autophagy that targets pathogens. Other inflammatory joint diseases may also stem from impaired xenophagy with persistence of bacteria or viruses that can event...
Source: Joint Bone Spine - September 29, 2017 Category: Orthopaedics Source Type: research

Association between hidradenitis suppurativa and spondyloarthritis
Conclusions Our results indicate that hidrosadenitis suppurativa is significantly associated with an increased risk of spondyloarthritis, independently of age and sex. Patients with hidrosadenitis suppurativa presenting osteoarticular symptoms, specially low back pain or dactylitis, should be monitored for spondyloarthritis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 29, 2017 Category: Orthopaedics Source Type: research

Comparison of ultrasonography and radiography of the wrist for diagnosis of calcium pyrophosphate deposition
Conclusion Our study suggests that wrist US should be considered as a relevant tool for the diagnosis of CPPD, with higher sensitivity than radiography for detecting CPP deposits. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 29, 2017 Category: Orthopaedics Source Type: research

Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints
Publication date: Available online 28 September 2017 Source:Joint Bone Spine Author(s): Bolan Li, Nora Singer, Ann Rosenthal, Mustafa Unal, Donard Haggins, Yener N. Yeni, Ozan Akkus (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 29, 2017 Category: Orthopaedics Source Type: research

Anti -citrullinated peptide antibodies profiling in established rheumatoid arthritis
Conclusions Higher number/levels of ACPA subtypes is associated with lung involvement but not with erosive disease. Moreover, a broader ACPA repertoire may identify patients treated with biological therapy, probably affected by a more severe disease. In conclusion, ACPA typing might be relevant for a better characterization of some disease features in established RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 21, 2017 Category: Orthopaedics Source Type: research

Lung transplantation for scleroderma: strength in numbers
Publication date: Available online 14 September 2017 Source:Joint Bone Spine Author(s): Allan C. Gelber (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 14, 2017 Category: Orthopaedics Source Type: research

Clinical Characteristics and Outcomes in Polyarticular Septic Arthritis
Conclusions In this sample of patients with septic arthritis, patients with septic polyarthritis were more likely to have systemic infection at presentation than those with septic monoarthritis. Despite this difference, patients with septic monoarthritis and polyarthritis tended to have similar outcomes. While rheumatoid arthritis was observed more frequently among patients with septic polyarthritis, those with/without underlying rheumatoid arthritis had similar presenting features and outcomes.Bottom of Form (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 14, 2017 Category: Orthopaedics Source Type: research

Poor efficacy of TNF inhibitors in non-radiographic axial spondyloarthritis in the absence of objective signs: a bicentric retrospective study
Conclusion TNFi should be used with caution in axSpA when objective signs are absent as only 13.7% of these patients were BASDAI50 responders at 3 months. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 14, 2017 Category: Orthopaedics Source Type: research

Hip Inflammation MRI Scoring System (HIMRISS) to predict response to hyaluronic acid injection in hip osteoarthritis
Conclusion HIMRISS is reliable for total scores and sub-domains. It permits identification of responders to HA injection in hip OA patients. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Incidence of cancer in patients with spondyloarthritis treated with anti-tnf drugs
Conclusions The incidence of malignancies among SpA patients treated with the three TNFi was higher than in general population; having had a previous solid cancer is predictive of a new malignancy. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Vitamin  D supplementation in patients treated for sarcoidosis: Controversy or consensus?
Publication date: October 2017 Source:Joint Bone Spine, Volume 84, Issue 5 Author(s): Nathalie Saidenberg-Kermanac’h, Dominique Valeyre, Marie-Christophe Boissier (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Ours r édaction
Publication date: October 2017 Source:Joint Bone Spine, Volume 84, Issue 5 (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Pain in osteoarthritis. Implications for optimal management
Publication date: Available online 6 September 2017 Source:Joint Bone Spine Author(s): Anne-Priscille Trouvin, Serge Perrot Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in various populations and is dramatically increasing in many countries, mostly related to age and obesity, leading to an increased number of people having OA pain, and creating a huge burden related to disability and health care costs. OA-related pain, has been classically considered to be a nociceptive pain condition. Clinicia...
Source: Joint Bone Spine - September 7, 2017 Category: Orthopaedics Source Type: research

Flexor tenosynovitis of the wrist including rice bodies
Publication date: Available online 27 July 2017 Source:Joint Bone Spine Author(s): Fatih Celikyay, Ruken Z. Yuksekkaya, Bora Bostan (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 2, 2017 Category: Orthopaedics Source Type: research

Anti Citrullinated Peptide Antibodies profiling in established rheumatoid arthritis
Conclusions Higher number/levels of ACPA subtypes is associated with lung involvement but not with erosive disease. Moreover, a broader ACPA repertoire may identify patients treated with biological therapy, probably affected by a more severe disease.In conclusion, ACPA typing might be relevant for a better characterization of some disease features in established RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 5, 2017 Category: Orthopaedics Source Type: research

New Classification for Juvenile Idiopathic Arthritis: Is the Tower of Babel Falling?
Publication date: Available online 5 August 2017 Source:Joint Bone Spine Author(s): Alexandre Belot (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 5, 2017 Category: Orthopaedics Source Type: research

Retroperitoneal fibrosis following a long-standing etanercept treatment in a spondyloarthritis patient
Publication date: Available online 6 June 2017 Source:Joint Bone Spine Author(s): Stefania Manganelli, Chiara Giannitti, Mauro Galeazzi, Marco Rossi (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 29, 2017 Category: Orthopaedics Source Type: research

Clinical predictors of magnetic resonance imaging-detected sacroiliitis in children with enthesitis related arthritis
Conclusion In children with enthesitis-related arthritis the presence of buttock pain or of abnormal sacroiliac joint examination is a strong predictor of magnetic sacroiliitis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 28, 2017 Category: Orthopaedics Source Type: research