Higher body fat and lower fat-free mass in girls with premature adrenarche.
We examined 47 girls with PA with a median age of 7.39 years and 57 healthy controls with a median age of 7.11 years. For PA group, the inclusion criteria were appearance of pubic/axillary hair before 8 years of age, absence of findings of central puberty and absence of use of any medication. Patients with steroidogenic enzyme defects and virilizing tumors were excluded. Height, body weight, waist and hip circumference were measured. The bioelectrical impedance method was used for body composition analysis. RESULTS: In the PA group, both body weight standard deviation score (SDS) and height SDS were significantly highe...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Epidemiologic Features of Type 1 Diabetic Patients between 0 and 18 Years of Age in İstanbul City.
CONCLUSION: The findings possibly indicate a decreasing age of T1DM onset. The high frequency of ketoacidosis at presentation is noteworthy. Girls had higher rates of ketoacidosis, higher frequency of anti-thyroid antibodies and higher insulin requirements as compared to boys. Patients with a family history of T1DM had higher initial glucose levels and higher frequency of anti-endomysial antibodies. PMID: 25800476 [PubMed - in process] (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Recognizing the psychosocial aspects of type 1 diabetes in adolescents.
Authors: Adal E, Önal Z, Ersen A, Yalçın K, Önal H, Aydın A Abstract OBJECTIVE: Considering the ever increasing population of diabetic adolescents and the association of the disease with psychosocial problems throughout its course, depression and/or anxiety and social support from parents are issues of special concern in these patients. The study aimed to identify the depression and anxiety state of diabetic adolescents and its impact on the management of diabetes mellitus (DM). METHODS: 295 adolescents with type 1 DM and their parents attended our study. Psychological distress was assessed u...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Social anxiety, depression and self-esteem in obese adolescent girls with acanthosis nigricans.
CONCLUSION: Higher SES scores (low self-esteem status) were determined in obese adolescents with acanthosis and were related to hyperandrogenism. This study also showed that a high testosterone level may be one of the important indicators of low self-esteem status in obese girls with AN. PMID: 25800478 [PubMed - in process] (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Rhizomelic Chondrodysplasia Punctata Type 1 Caused by a Novel Mutation in the PEX7 Gene.
In conclusion, the clinical presentation and peroxisome profile of the patient suggest that this novel mutation leads to RCDP type 1. PMID: 25800479 [PubMed - in process] (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

A case of thanatophoric dysplasia type 2: a novel mutation.
We report a male patient who showed clinical findings congruent with TD type 2 and a new mutation in the FGFR3 gene, a finding which has not been reported previously. PMID: 25800480 [PubMed - in process] (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Recovery of Central Fever after GH Therapy in a Patient with GH Deficiency Secondary to Posttraumatic Brain Injury.
Authors: Ünver Tuhan H, Anık A, Çatlı G, Abacı A, Öztürk T, Güleryüz H, Böber E Abstract Growth hormone (GH) deficiency is the most common pituitary hormone deficiency after traumatic brain injury. Patients with GH deficiency have a reduced sweating capacity which increases the risk of developing hyperthermia. To the best of our knowledge, central fever that developed due to GH deficiency and improved with GH treatment has not yet been reported. In this article, we present a case of dramatic improvement of central fever with recombinant human GH therapy in a patient with post...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Autoimmune polyglandular syndrome type 2: a rare condition in childhood.
Authors: Kırmızıbekmez H, Yeşiltepe Mutlu RG, Demirkıran Urgancı N, Öner A Abstract Autoimmune polyglandular syndrome type 2 is defined as the occurrence of Addison's disease concomitantly with autoimmune thyroid disease and/or type 1 diabetes mellitus. An 11-year-old boy with Hashimoto's disease, Addison's disease, celiac disease and Langerhans islet cell autoimmunity is described in this case report. Treatment of an endocrine disease may also trigger the onset of another endocrine disease. This case report underlines the importance of early recognition and treatment of critical endocrine diseases as we...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Capillary bedside blood glucose measurement in neonates: missing a diagnosis of galactosemia.
We report a newborn patient who was referred to our hospital with conjugated bilirubinemia, hepatomegaly and high capillary blood glucose levels measured with a glucometer. Simultaneous biochemical measurements revealed normal blood glucose levels. Further investigation led to a diagnosis of classical galactosemia. Capillary blood glucose level measured with glucometer also dropped to normal values following cessation of breastfeeding and initiation of feeding with a lactose-free formula. PMID: 25800483 [PubMed - in process] (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - June 4, 2015 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research