Reporting and Sharing Matters
(Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - November 13, 2023 Category: ENT & OMF Source Type: research

Review and Perspective on Brain Bases of Tinnitus
AbstractIn advancing our understanding of tinnitus, some of the more impactful contributions in the past two decades have come from human brain imaging studies, specifically the idea of both auditory and extra-auditory neural networks that mediate tinnitus. These networks subserve both the perception of tinnitus and the psychological reaction to chronic, continuous tinnitus. In this article, we review particular studies that report on the nodes and links of such neural networks and their inter-network connections. Innovative neuroimaging tools have contributed significantly to the increased understanding of anatomical and ...
Source: JARO - Journal of the Association for Research in Otolaryngology - November 2, 2023 Category: ENT & OMF Source Type: research

Histological Correlates of Auditory Nerve Injury from Kainic Acid in the Budgerigar (Melopsittacus undulatus)
ConclusionCompound auditory nerve responses and wave I provide a useful index of cochlear synaptopathy in this animal model. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - October 5, 2023 Category: ENT & OMF Source Type: research

Somatosensory Tinnitus: Recent Developments in Diagnosis and Treatment
AbstractSomatosensory tinnitus (ST) is a type of tinnitus where changes in somatosensory input from the head-neck area are one of the influencing factors of a patient ’s tinnitus. As there are often several influencing factors, identifying a clear somatosensory influence on an individual patient’s tinnitus is often a challenge. Therefore, a decision tree using four clinical criteria has been proposed that can help diagnose ST with an accuracy of 82.2%, a sens itivity of 82.5%, and a specificity of 79%. Once correctly diagnosed, patients can be successfully treated using a musculoskeletal physical therapy treatment. Thi...
Source: JARO - Journal of the Association for Research in Otolaryngology - October 4, 2023 Category: ENT & OMF Source Type: research

Polygenic Risk Score-Based Association Analysis of Speech-in-Noise and Hearing Threshold Measures in Healthy Young Adults with Self-reported Normal Hearing
ConclusionThese results indicate that healthy individuals with polygenic risk of certain health conditions could exhibit a subclinical decline in hearing health measures at young ages, decades before clinically meaningful SIN deficits and hearing loss could be observed. PRS could be used to identify high-risk individuals to prevent hearing health conditions by promoting a healthy lifestyle. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - October 2, 2023 Category: ENT & OMF Source Type: research

Sheep as a Large-Animal Model for Otology Research: Temporal Bone Extraction and Transmastoid Facial Recess Surgical Approach
ConclusionWe identified anatomic landmarks for temporal bone extraction and describe an extended facial recess approach in sheep that exposes the ossicles and round window. This approach is feasible for studying implantable hearing devices. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - September 8, 2023 Category: ENT & OMF Source Type: research

An Opportunity for Constructing the Future of Data Sharing in Otolaryngology
(Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - August 10, 2023 Category: ENT & OMF Source Type: research

The Next Challenges of Vestibular Implantation in Humans
AbstractPatients with bilateral vestibulopathy suffer from a variety of complaints, leading to a high individual and social burden. Available treatments aim to alleviate the impact of this loss and improve compensatory strategies. Early experiments with electrical stimulation of the vestibular nerve in combination with knowledge gained by cochlear implant research, have inspired the development of a vestibular neuroprosthesis that can provide the missing vestibular input. The feasibility of this concept was first demonstrated in animals and later in humans. Currently, several research groups around the world are investigat...
Source: JARO - Journal of the Association for Research in Otolaryngology - July 29, 2023 Category: ENT & OMF Source Type: research

Distortion Product Otoacoustic Emissions in Mice Above and Below the Eliciting Primaries
This study evaluated how loss of sensitivity affects DPOAEs with frequencies above and below the stimulating primaries, i.e., for upper sideband (USB) components like 2f2-f1 and for lower sideband (LSB) components like 2f1-f2. DPOAEs were recorded in several mouse mutants with varying degrees of hearing loss associated with structural changes to the tectorial membrane (TM), or with loss of outer hair cell (OHC) somatic electromotility due to lack of prestin or to the expression of a non-functional prestin. In mice with changes in sensitivity, magnitude reductions were observed for 2f1-f2 relative to controls with mice lack...
Source: JARO - Journal of the Association for Research in Otolaryngology - July 18, 2023 Category: ENT & OMF Source Type: research

Frequency Following Responses to Tone Glides: Effects of Age and Hearing Loss
ConclusionThe overall distribution of FFRs across listeners and stimulus conditions suggests that observed group differences associated with age and hearing loss are influenced by a decreased likelihood of older and hearing-impaired individuals having a detectable FFR response and by lower average FFR fidelity among those older and hearing-impaired individuals who do have a detectable response. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - July 12, 2023 Category: ENT & OMF Source Type: research

Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity
ConclusionThe current study reveals that patients with moderate-to-severe tinnitus demonstrate greater changes in the central brain areas, including the auditory cortex, insula, parahippocampus and posterior cingulate gyrus. In addition, enhanced connections were found between the insula and the auditory cortex, as well as the posterior cingulate gyrus and the parahippocampus, which suggests abnormality in the auditory network, salience network, and default mode network. Specifically, the insula is the core region of the neural pathway that is composed of the auditory cortex, insula, and parahippocampus/posterior cingulate...
Source: JARO - Journal of the Association for Research in Otolaryngology - July 12, 2023 Category: ENT & OMF Source Type: research

Frequency Following Responses to Tone Glides: Effects of Age and Hearing Loss
ConclusionThe overall distribution of FFRs across listeners and stimulus conditions suggests that observed group differences associated with age and hearing loss are influenced by a decreased likelihood of older and hearing-impaired individuals having a detectable FFR response and by lower average FFR fidelity among those older and hearing-impaired individuals who do have a detectable response. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - July 12, 2023 Category: ENT & OMF Source Type: research

Abnormal Functional Connectivity Within Default Mode Network and Salience Network Related to Tinnitus Severity
ConclusionThe current study reveals that patients with moderate-to-severe tinnitus demonstrate greater changes in the central brain areas, including the auditory cortex, insula, parahippocampus and posterior cingulate gyrus. In addition, enhanced connections were found between the insula and the auditory cortex, as well as the posterior cingulate gyrus and the parahippocampus, which suggests abnormality in the auditory network, salience network, and default mode network. Specifically, the insula is the core region of the neural pathway that is composed of the auditory cortex, insula, and parahippocampus/posterior cingulate...
Source: JARO - Journal of the Association for Research in Otolaryngology - July 12, 2023 Category: ENT & OMF Source Type: research

Quantitative Evaluation of the 3D Anatomy of the Human Osseous Spiral Lamina Using MicroCT
ConclusionBy enhancing our comprehension of the OSL, we can advance our comprehension of hearing mechanisms and enhance the accuracy and effectiveness of cochlear models. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - July 5, 2023 Category: ENT & OMF Source Type: research