Conditions, possibility and priority for admission into inpatient hospice/palliative care units in Japan: a nationwide survey
ConclusionsThe findings of this study should be used to modify the system so that appropriate palliative care can be provided to patients who wish to be admitted to PCU. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 28, 2021 Category: Cancer & Oncology Source Type: research

Oncologic and survival outcomes in elderly patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy and total mesorectal excision
ConclusionFor elderly locally advanced rectal cancer patients who have good health and performance status, the addition of neoadjuvant chemotherapy to neoadjuvant chemoradiotherapy and total mesorectal excision can result in disease-related survival rates and oncological outcomes similar to those experienced by younger patients. The decision to use this treatment approach in elderly patients should not be based solely on chronological age. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 21, 2021 Category: Cancer & Oncology Source Type: research

Transferrin predicts outcome in patients who underwent liver resection for colorectal liver metastases
ConclusionsThe serum transferrin level is a useful predictor of poor overall survival in patients with colorectal liver metastases after hepatic reaction. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 17, 2021 Category: Cancer & Oncology Source Type: research

A new window connecting medical oncologists and interventional oncologists
The article titled ‘Transarterial management of advanced lung cancer’ (1) introduces excellent clinical outcomes. It is a retrospective review of cases of patient who received very special treatments, such as super-selective arterial infusion chemotherapy and embolotherapy, and it is likely that the cohort included in this study were lucky cases showing good clinical results by chance. Hence, it is not adequate enough to call these findings as ‘evidence’. However, is it correct to ignore these results for not providing sufficient evidence? (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 17, 2021 Category: Cancer & Oncology Source Type: research

Age-specific larynx cancer incidence rate in the world
In order to make a comparison of the age-specific skin cancer incidence rate between Japan and other countries, we abstracted cancer incidence rate from the Cancer Incidence in Five Continents Vol. XI (CI5) (1). The International Agency for Research on Cancer provides the CI5 databases on the incidence of cancer recorded by cancer registries (regional and national) worldwide. We used cancer incidence rate in five countries in Asia (China, India, Japan, Republic of Korea and Thailand), three countries in America (the USA, Canada and Brazil), two countries in Oceania (Australia and New Zealand) and four countries in Europe (...
Source: Japanese Journal of Clinical Oncology - June 16, 2021 Category: Cancer & Oncology Source Type: research

Cost-effectiveness of trifluridine/tipiracil against nivolumab for heavily pretreated metastatic gastric cancer in Japan
ConclusionsTrifluridine/tipiracil was more cost-effective than nivolumab for patients with heavily pretreated metastatic gastric cancer. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 14, 2021 Category: Cancer & Oncology Source Type: research

Treatment outcomes of erlotinib plus gemcitabine as late-line chemotherapy in unresectable pancreatic cancer
ConclusionsBenefits of erlotinib plus gemcitabine as late-line chemotherapy were limited, particularly with respect to PFS. Development of more effective third-line treatment options is desirable in the future. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 14, 2021 Category: Cancer & Oncology Source Type: research

Stereotactic body radiation therapy for Japanese patients with localized prostate cancer: 2-year results and predictive factors for acute genitourinary toxicities
ConclusionsStereotactic body radiation therapy is feasible for Japanese patients with prostate cancer, with acceptable acute toxicity. Age, genitourinary toxicity at baseline and bladder mean dose predict grade 2 acute genitourinary toxicity. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 14, 2021 Category: Cancer & Oncology Source Type: research

Survival of chemo-na ïve patients with EGFR mutation-positive advanced non-small cell lung cancer after treatment with afatinib and bevacizumab: updates from the Okayama Lung Cancer Study Group Trial 1404
ConclusionsProlonged follow-up revealed that combination therapy with afatinib and bevacizumab might improve survival outcomes inEGFR-mutant advanced non-small-cell lung cancer patients and seems to be promising.Trial registrationUMIN000015944. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 12, 2021 Category: Cancer & Oncology Source Type: research

Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study)
ConclusionThe objective response rate and median survival time in Japanese patients treated with nivolumab were lower in daily practice than the>30% and  >30  months, respectively, seen in global phase III trials. The occurrence of immune-related adverse events may be a predictor for survival and response to treatment with nivolumab. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 12, 2021 Category: Cancer & Oncology Source Type: research

Unmet need for palliative rehabilitation in inpatient hospices/palliative care units: a nationwide post-bereavement survey
AbstractIn end-of-life care, rehabilitation for terminally ill cancer patients is inconsistently provided and rarely discussed. We sought to clarify the prevalence of unmet rehabilitation need for patients admitted to inpatient hospice/palliative care units as perceived by bereaved family members. We conducted a nationwide questionnaire survey of 1001 family members of cancer patients who died at inpatient hospices/palliative care units. For cancer patients who did not receive rehabilitation, we asked if family members perceived that the patient would have wanted rehabilitation intervention. Data were obtained from 416 res...
Source: Japanese Journal of Clinical Oncology - June 11, 2021 Category: Cancer & Oncology Source Type: research

The ‘other’ bone sarcomas in Japan: a retrospective study of primary bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma, using data from the Bone Tumuor Registry in Japan
ConclusionsPatients with bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma without metastasis at presentation have a relatively good prognosis with definitive surgery; however, the benefit of adjuvant chemotherapy is unclear. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 9, 2021 Category: Cancer & Oncology Source Type: research

Unusual presentation of metastatic radiogenic breast angiosarcoma
A 56-year-old woman underwent quadrantectomy with axillary dissection followed by adjuvant radiotherapy (RT) with 30  Gy for a mucinous carcinoma of the left breast (T1cN0M0). Because oestrogen and progesteron receptors were positive, she was given antihormonal therapy for 5 years. Nine years later, the patient underwent local excision of a 0.7 × 0.8 cm pigmented papule skin lesion of the operated breast. Hist ology revealed high-grade angiosarcoma (Fig. 1a), and immunohistochemistry was positive for CD31 (Fig. 1b) and CD34, whereas c-myc amplification was negative at fluorencein situ hybridization (FISH). Because of t...
Source: Japanese Journal of Clinical Oncology - June 9, 2021 Category: Cancer & Oncology Source Type: research

Feasibility of conversion thoracoscopic esophagectomy after induction therapy for locally advanced unresectable esophageal squamous cell carcinoma
ConclusionsThoracoscopic esophagectomy is as safe and feasible as open esophagectomy for conversion surgery after induction therapy for locally advanced unresectable esophageal squamous cell carcinoma. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 9, 2021 Category: Cancer & Oncology Source Type: research

Clinical outcomes of endoprosthetic reconstruction for proximal femoral resection
ConclusionThe results of proximal femoral resection and reconstruction with a modular bipolar-type prosthesis were found to be acceptable with infection and local recurrence as short-term complications and loosening and acetabular erosion as long-term complications. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - June 8, 2021 Category: Cancer & Oncology Source Type: research