Immunotherapy for squamous cell carcinoma of the head and neck
AbstractSquamous cell carcinoma of the head and neck is characterized by an immunosuppressive environment and evades immune responses through multiple resistance mechanisms. A breakthrough in cancer immunotherapy employing immune checkpoint inhibitors has evolved into a number of clinical trials with antibodies against programmed cell death 1 (PD-1), its ligand PD-L1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) for patients with squamous cell carcinoma of the head and neck. CheckMate141 and KEYNOTE-048 were practice-changing randomized phase 3 trials for patients with platinum-refractory and platinum-sensitive ...
Source: Japanese Journal of Clinical Oncology - August 8, 2020 Category: Cancer & Oncology Source Type: research

Metastatic renal cell carcinoma to the pancreas with tumor thrombus in the main pancreatic duct
renal cell carcinomapancreatic metastasistumor thrombus (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 6, 2020 Category: Cancer & Oncology Source Type: research

Diverse transitions in diabetes status during the clinical course of patients with resectable pancreatic cancer
ConclusionsIn pancreatic cancer patients who underwent pancreatectomy, distal pancreatectomy was correlated with postoperative diabetes, and newly diagnosed diabetes had a high probability of resolution after resection. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 6, 2020 Category: Cancer & Oncology Source Type: research

Present status of support for adolescent and young adult cancer patients in member hospitals of Japanese Association of Clinical Cancer Centers
Conclusionssupport systems and activities for adolescent and young adult cancer patients vary extremely across hospitals. Information provision and consultation for unmet needs are still insufficient. Therefore, sharing information and experiences is required to enhance the support for adolescent and young adult cancer patients. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 6, 2020 Category: Cancer & Oncology Source Type: research

Does Xylinas ’ nomogram accurately predict intravesical recurrence risk after radical nephroureterectomy for primary upper urinary tract urothelial carcinoma when applied to Asian populations?
ConclusionsThis nomogram appears accurate at predicting intravesical recurrence after radical nephroureterectomy for primary urinary tract urothelial carcinoma in Asian populations. However, it remains necessary to data mine for unknown prognostic factors for optimization. Further external validation is required across larger, ethically diverse populations before applying this nomogram in clinical practice. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - July 31, 2020 Category: Cancer & Oncology Source Type: research