Medicare Advantage Disenrollment Among Beneficiaries With Chronic Conditions
To the Editor A recently published Research Letter on Medicare Advantage (MA) disenrollment patterns is misleading about the harms of MA to vulnerable patients enrolled in MA, which is not Medicare but a private, for-profit insurance plan. (Source: JAMA)
Source: JAMA - December 12, 2023 Category: General Medicine Source Type: research
Disease as an Aftermath of War
When the war trumpets blow, the peoples must dance. No place so remote, no family so isolated that it may not be affected by a conflict seemingly as outside its sphere of interest as the planet Saturn. War, famine and pestilence ride together as well chosen comrades. Disease is a consequence of modern war as direct and inevitable as bullet wounds. (Source: JAMA)
Source: JAMA - December 12, 2023 Category: General Medicine Source Type: research
Audio Highlights
Listen to the JAMA Editor ’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA. (Source: JAMA)
Source: JAMA - December 12, 2023 Category: General Medicine Source Type: research
Metformin for Diabetes in Pregnancy
The incidence of gestational diabetes and type 2 diabetes in pregnancy is increasing at an alarming rate, while adverse pregnancy outcomes remain high. For this reason, clinicians and patients welcome randomized clinical trials (RCTs) to explore ways for improving outcomes in these vulnerable populations. In this issue of JAMA and in an issue of JAMA published in October 2023, 2 trials investigate the role of metformin during pregnancy to improve adverse outcomes: one trial in women with gestational diabetes and one trial in those with type 2 diabetes. (Source: JAMA)
Source: JAMA - December 12, 2023 Category: General Medicine Source Type: research
Missing Acknowledgment
This article was corrected online. (Source: JAMA)
Source: JAMA - December 12, 2023 Category: General Medicine Source Type: research
Jama
(Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Reporting of Factorial Randomized Trials
This article provides an extension of the Consolidated Standards of Reporting Trials 2010 checklist for the reporting of factorial trials. (Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Some of Us
(outside a mental health centerin Philadelphia) (Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Adenotonsillectomy for Treatment of Mild Sleep-Disordered Breathing in Children
This randomized clinical trial evaluates whether early adenotonsillectomy, compared with watchful waiting and supportive care, improves neurodevelopmental, behavioral, health, and polysomnographic outcomes in US children with mild sleep-disordered breathing. (Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis
This prospective, nonrandomized clinical trial assesses neonatal outcomes after serial amnioinfusions initiated before 26 weeks ’ gestation to mitigate lethal pulmonary hypoplasia in pregnancies complicated by bilateral renal agenesis. (Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer
This randomized clinical trial evaluates whether sintilimab plus chemotherapy vs placebo plus chemotherapy improved overall survival in patients in China with unresectable, locally advanced, recurrent, or metastatic gastric or gastroesophageal junction adenocarcinoma. (Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Treatment of Adults Hospitalized With COVID-19 Pneumonia —Reply
In Reply We thank Drs Mathew and Feldmann for their comments on the results of ACTIV-1. We agree that mortality is a very important clinical outcome, but designing a trial such as ACTIV-1 to have sufficient power to detect an effect on mortality was challenging in June 2020, when data on clinical outcomes of severe COVID-19 were in flux. Indeed, the design of ACTIV-1 was heavily influenced by the results of ACTT-1, the initial placebo-controlled trial of remdesivir, which showed evidence of improved time to recovery but not improved mortality. (Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Primary HPV Screening vs Cotesting for Cervical Cancer —Reply
In Reply Our comprehensive Review of cervical cancer screening describes the HPV natural history underlying cervical cancer and further describes how national guidelines use this knowledge to improve care for patients by focusing on screening, diagnostic, and treatment services in higher-risk patients while decreasing testing and invasive procedures in lower-risk patients. The purpose of the article was to educate clinicians on the basic science underlying evidence-based clinical management as well as review current guidelines. Because HPV causes nearly all cervical cancers and HPV testing is more sensitive than cytology, ...
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Treatment of Adults Hospitalized With COVID-19 Pneumonia
To the Editor We have several comments about the recent randomized clinical trial (ACTIV-1) that investigated the effect of abatacept, cenicriviroc, or infliximab on COVID-19 pneumonia. (Source: JAMA)
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
Primary HPV Screening vs Cotesting for Cervical Cancer
To the Editor A recent Review recommended human papillomavirus (HPV) testing as the primary screening test for cervical cancer. However, the authors neglected to explore the consequences of endorsing HPV primary screening over cotesting, which includes cytological evaluation. The authors did not discuss the importance of HPV-negative neoplasms. These cases include cervical intraepithelial neoplasia grade 3 or worse (CIN3+) lesions (false-negative results as well as HPV subtypes not included in commonly used HPV testing kits) and neoplasms that are not caused by HPV, for example, about 20% of cervical adenocarcinomas. In ad...
Source: JAMA - December 5, 2023 Category: General Medicine Source Type: research
