Evolving Trends in Immunohistochemistry Use in Dermatopathology
In this issue of JAMA Dermatology, Ojukwu and colleagues analyzed the use of immunohistochemistry (IHC) in melanoma specimens within the Surveillance, Epidemiology, and End Results –Medicare cancer registry database over 18 years. The authors were able to identify 132 547 distinct melanoma biopsies in 116 117 individual patients 65 years or older. Ojukwu et al found that the use of IHC staining increased among all specimen types. In particular, the use of IHC in melanoma cases increased from 11% in 2000 to 51% in 2017, with a statistically significant increase noted in association with all demographic and tumor chara...
Source: JAMA Dermatology - March 6, 2024 Category: Dermatology Source Type: research
Erythematous Plaque Studded With Papules and Pustules in an Immunocompetent Patient
A male patient was evaluated by the dermatology inpatient consult service after a 5-week history of a skin lesion on the right anterior thigh with intermittent itching and mild tenderness to palpation. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - March 6, 2024 Category: Dermatology Source Type: research
Symptoms of Cognitive Impairment Among Children With Atopic Dermatitis
This cross-sectional study examines whether atopic dermatitis is associated with symptoms of learning or memory difficulties in US children. (Source: JAMA Dermatology)
Source: JAMA Dermatology - March 6, 2024 Category: Dermatology Source Type: research
Immunohistochemistry for Diagnosing Melanoma in Older Adults
This retrospective cross-sectional study illustrates national-level trends in immunohistochemistry staining for the diagnosis of melanoma in older adult patients enrolled in Medicare. (Source: JAMA Dermatology)
Source: JAMA Dermatology - March 6, 2024 Category: Dermatology Source Type: research
JAMA Dermatology
Mission Statement: JAMA Dermatology’s mission is to elevate the art and science of health and diseases of skin, hair, nails, and mucous membranes, and their treatment, to enable dermatologists to deliver evidence-based, high-value medical and surgical dermatologic care. The journal publishes a broad range of inn ovative studies and trials that shift research and clinical practice paradigms, expand the understanding of the burden of dermatologic diseases and key outcomes, improve the practice of dermatology, and ensure equitable care to all patients. The journal also features research and opinion examining e thical, m...
Source: JAMA Dermatology - March 1, 2024 Category: Dermatology Source Type: research
Patient-Reported Outcomes and Mortality in Cutaneous Chronic Graft-vs-Host Disease
This cohort study examines the association of chronic graft-vs-host disease subtype with patient-reported outcomes and evaluates whether these measures can identify patients at higher risk for death. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 28, 2024 Category: Dermatology Source Type: research
Incidence and Factors in Second Primary Invasive Melanoma in Norway
This cohort study assesses the incidence rate of second primary invasive melanoma at least 30 days after the first based on data from deidentified records of all invasive melanomas diagnosed in 2008 to 2020, obtained from the Cancer Registry of Norway. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 28, 2024 Category: Dermatology Source Type: research
Spesolimab for Acrodermatitis Continua of Hallopeau
This case report summarizes the treatment of acrodermatitis continua of Hallopeau with spesolimab in a 9-year-old girl. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 28, 2024 Category: Dermatology Source Type: research
Improving Outcomes in Chronic Graft-vs-Host Disease
Chronic graft-vs-host disease (cGVHD) is a frequent, heterogeneous, and often life-threatening complication of allogeneic hematopoietic stem cell transplantation. A total of 25% to 50% of all transplant survivors develop cGVHD, and cutaneous manifestations are seen in approximately 75% of these patients. Cutaneous manifestations of cGVHD include skin fibrosis (sclerotic cGVHD), epidermal involvement resembling lichen planus, or a combination of both findings. Alopecia, genital inflammation/scarring, nail dystrophy, pigmentary changes, ulceration, and poor wound healing are additional features. Associated skin changes range...
Source: JAMA Dermatology - February 28, 2024 Category: Dermatology Source Type: research
Efficiency Frontiers to Align Prices and Benefits of Biologic Therapies for Plaque Psoriasis
This economic evaluation assesses how the efficiency frontier approach could align prices and clinical benefits of biologic medications for plaque psoriasis and estimates price reductions in the US vs 4 peer countries. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 21, 2024 Category: Dermatology Source Type: research
Cooling Research Fever in Dermatology —The Role of Community Service—Reply
In Reply We appreciate the thoughtful response by Zhang et al to our article and agree with their points. Community service is extremely relevant to dermatology and should be highlighted as a way for trainees to explore dermatology, serve and learn about diverse communities and their needs, and improve the field and our care of patients. As more and more residency programs implement mission-driven holistic review, we imagine that many will add community service as a specific target for student engagement. Reinforcing and sustaining this will take collaboration from educational leaders and others across the field of dermato...
Source: JAMA Dermatology - February 21, 2024 Category: Dermatology Source Type: research
Cooling Research Fever in Dermatology —The Role of Community Service
To the Editor We read with interest the recent Viewpoint by Gandelman et al that highlighted research fever in dermatology, which refers to the field ’s growing overemphasis on research output and the concurrent rise in the average number of abstracts, presentations, and publications of applicants matched into dermatology. We agree with the authors that research fever is a complex, multifactorial problem for which there may not be a simple, sin gular quick fix. However, one solution mentioned in mere passing, but which we believe deserves greater consideration and emphasis, is increasing the importance of community servi...
Source: JAMA Dermatology - February 21, 2024 Category: Dermatology Source Type: research
Matching Drug Prices to Their Clinical Benefit —The Final Frontier?
In this issue of JAMA Dermatology, Egilman et al show how efficiency frontiers (EFs) can be used to align the prices and clinical benefits of biologics for plaque psoriasis. This is particularly timely given that the Inflation Reduction Act of 2022 granted Medicare (the federal health insurance program for those 65 years and older) the right to negotiate drug prices (on the basis of comparative safety, effectiveness, and development costs and subsidies) for the first time. Negotiation is limited to the top 10 highest-spend drugs initially but will be expanded. In addition, as well as limits on above-inflation price increas...
Source: JAMA Dermatology - February 21, 2024 Category: Dermatology Source Type: research
Annular Erythematous Eruption in a Pediatric Patient
An 11-year-old girl presented in autumn with an asymptomatic rash on her arms, face, and legs of a 3-week duration. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 21, 2024 Category: Dermatology Source Type: research
Identifying Core Outcome Domains in Chronic Skin Disease Using the Best-Worst Scaling Method
This cross-sectional study examines which Patient-Reported Outcomes Measurement Information System domains are most meaningful to those with chronic skin disease. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 21, 2024 Category: Dermatology Source Type: research
