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Associations of Acid Suppressive Therapy With Cardiac Mortality in Heart Failure Patients [Heart Failure]
ConclusionsPPIs may be associated with better outcome in patients with heart failure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 16, 2017 Category: Cardiology Authors: Yoshihisa, A., Takiguchi, M., Kanno, Y., Sato, A., Yokokawa, T., Miura, S., Abe, S., Misaka, T., Sato, T., Suzuki, S., Oikawa, M., Kobayashi, A., Yamaki, T., Kunii, H., Nakazato, K., Suzuki, H., Saitoh, S.-i., Takeishi, Y. Tags: Heart Failure Original Research Source Type: research

Endogenous Hydrogen Sulfide Enhances Carotid Sinus Baroreceptor Sensitivity by Activating the Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Channel [Hypertension]
ConclusionsH2S regulated blood pressure via an increase in TRPV1 protein expression and its activity to enhance carotid sinus baroreceptor sensitivity. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 16, 2017 Category: Cardiology Authors: Yu, W., Liao, Y., Huang, Y., Chen, S. Y., Sun, Y., Sun, C., Wu, Y., Tang, C., Du, J., Jin, H. Tags: Vascular Biology, High Blood Pressure, Hypertension Original Research Source Type: research

Alogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits [Arrhythmia and Electrophysiology]
ConclusionsDipeptidyl peptidase‐4 inhibitors can prevent atrial fibrillation by reversing electrophysiological abnormalities, improving mitochondrial function, and promoting mitochondrial biogenesis. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 15, 2017 Category: Cardiology Authors: Zhang, X., Zhang, Z., Zhao, Y., Jiang, N., Qiu, J., Yang, Y., Li, J., Liang, X., Wang, X., Tse, G., Li, G., Liu, T. Tags: Arrhythmias, Electrophysiology Original Research Source Type: research

Change in Physical Activity and Sitting Time After Myocardial Infarction and Mortality Among Postmenopausal Women in the Women's Health Initiative-Observational Study [Epidemiology]
BackgroundHow physical activity (PA) and sitting time may change after first myocardial infarction (MI) and the association with mortality in postmenopausal women is unknown.Methods and ResultsParticipants included postmenopausal women in the Women's Health Initiative‐Observational Study, aged 50 to 79 years who experienced a clinical MI during the study. This analysis included 856 women who had adequate data on PA exposure and 533 women for sitting time exposures. Sitting time was self‐reported at baseline, year 3, and year 6. Self‐reported PA was reported at baseline through year 8. Change in PA and sitting time w...
Source: JAHA:Journal of the American Heart Association - May 15, 2017 Category: Cardiology Authors: Gorczyca, A. M., Eaton, C. B., LaMonte, M. J., Manson, J. E., Johnston, J. D., Bidulescu, A., Waring, M. E., Manini, T., Martin, L. W., Stefanick, M. L., He, K., Chomistek, A. K. Tags: Aging, Cardiovascular Disease, Epidemiology, Exercise, Women Original Research Source Type: research

American College of Cardiology/American Heart Association (ACC/AHA) Class I Guidelines for the Treatment of Cholesterol to Reduce Atherosclerotic Cardiovascular Risk: Implications for US Hispanics/Latinos Based on Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) [Epidemiology]
ConclusionsThe eligibility of statin therapy increased consistently across all Hispanic/Latinos subgroups under the 2013 ACC/AHA guidelines and therefore will potentially increase the number of undertreated Hispanic/Latinos in the United States. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 11, 2017 Category: Cardiology Authors: Qureshi, W. T., Kaplan, R. C., Swett, K., Burke, G., Daviglus, M., Jung, M., Talavera, G. A., Chirinos, D. A., Reina, S. A., Davis, S., Rodriguez, C. J. Tags: Cardiovascular Disease, Epidemiology Original Research Source Type: research

Survival in Women Versus Men Following Implantation of Pacemakers, Defibrillators, and Cardiac Resynchronization Therapy Devices in a Large, Nationwide Cohort [Arrhythmia and Electrophysiology]
BackgroundWhether outcomes differ between sexes following treatment with pacemakers (PM), implantable cardioverter defibrillators, and cardiac resynchronization therapy (CRT) devices is unclear.Methods and ResultsConsecutive US patients with newly implanted PM, implantable cardioverter defibrillators, and CRT devices from a large remote monitoring database between 2008 and 2011 were included in this observational cohort study. Sex‐specific all‐cause survival postimplant was compared within each device type using a multivariable Cox proportional hazards model, stratified on age and adjusted for remote monitoring utiliza...
Source: JAHA:Journal of the American Heart Association - May 10, 2017 Category: Cardiology Authors: Varma, N., Mittal, S., Prillinger, J. B., Snell, J., Dalal, N., Piccini, J. P. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Heart Failure, Mortality/Survival Original Research Source Type: research

Patients With Heart Failure Readmitted to the Original Hospital Have Better Outcomes Than Those Readmitted Elsewhere [Health Services and Outcomes Research]
BackgroundUp to one fifth of readmissions after a heart failure hospitalization occur at a different hospital. This negatively impacts information continuity, but whether site of readmission impacts subsequent outcomes is unclear.Methods and ResultsRetrospective cohort study of all patients discharged with a primary diagnosis of heart failure in Canada between April 2004 and December 2013. We compared patients readmitted within 30 days to the original hospital versus a different hospital. Of the 217 039 heart failure patients (mean age, 76.8 years, 50.1% male), 39 368 (18.1%) were readmitted within 30 days—32 771 (...
Source: JAHA:Journal of the American Heart Association - May 10, 2017 Category: Cardiology Authors: McAlister, F. A., Youngson, E., Kaul, P. Tags: Epidemiology, Heart Failure, Health Services Original Research Source Type: research

Lifestyle and Risk of Screening-Detected Abdominal Aortic Aneurysm in Men [Epidemiology]
ConclusionsThis prospective study confirms that modifiable lifestyle‐related factors are associated with AAD and with AAA disease. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 10, 2017 Category: Cardiology Authors: Stackelberg, O., Wolk, A., Eliasson, K., Hellberg, A., Bersztel, A., Larsson, S. C., Orsini, N., Wanhainen, A., Bȷorck, M. Tags: Epidemiology, Exercise, Lifestyle, Obesity, Risk Factors Original Research Source Type: research

Race-Sex Differences in Statin Use and Low-Density Lipoprotein Cholesterol Control Among People With Diabetes Mellitus in the Reasons for Geographic and Racial Differences in Stroke Study [Health Services and Outcomes Research]
BackgroundStatin therapy is a cornerstone of cardiovascular disease risk reduction for people with diabetes mellitus. Past reports have shown race‐sex differences in statin use in general populations, but statin patterns by race and sex in those with diabetes mellitus have not been thoroughly studied.Methods and ResultsOur sample of 4288 adults ≥45 years of age with diagnosed diabetes mellitus who had low‐density lipoprotein cholesterol (LDL‐C)>100 mg/dL or were taking statins recruited for the Reasons for Geographic and Racial Differences in Stroke study from 2003 to 2007. Exposures included race‐sex groups (w...
Source: JAHA:Journal of the American Heart Association - May 10, 2017 Category: Cardiology Authors: Gamboa, C. M., Colantonio, L. D., Brown, T. M., Carson, A. P., Safford, M. M. Tags: Lipids and Cholesterol, Diabetes, Type 2, Epidemiology, Race and Ethnicity, Health Services Original Research Source Type: research

Heart Rate Recovery and Risk of Cardiovascular Events and All–Cause Mortality: A Meta–Analysis of Prospective Cohort Studies [Systematic Review and Meta-Analysis]
BackgroundHeart rate recovery (HRR) is a noninvasive assessment of autonomic dysfunction and has been implicated with risk of cardiovascular events and all‐cause mortality. However, evidence has not been systematically assessed. We performed a meta‐analysis of prospective cohort studies to quantify these associations in the general population.Methods and ResultsA literature search using 3 databases up to August 2016 was conducted for studies that reported hazard ratios with 95% CIs for the association between baseline HRR and outcomes of interest. The overall hazard ratios were calculated using a random‐effects model...
Source: JAHA:Journal of the American Heart Association - May 9, 2017 Category: Cardiology Authors: Qiu, S., Cai, X., Sun, Z., Li, L., Zuegel, M., Steinacker, J. M., Schumann, U. Tags: Electrophysiology, Cardiovascular Disease, Epidemiology, Exercise Systematic Review and Meta ‐ Analysis Source Type: research

Different Determinants of Ventilatory Inefficiency at Different Stages of Reduced Ejection Fraction Chronic Heart Failure Natural History [Heart Failure]
BackgroundIt is not known whether determinants of ventilation (VE)/volume of exhaled carbon dioxide (VCO2) slope during incremental exercise may differ at different stages of reduced ejection fraction chronic heart failure natural history.Methods and ResultsVE/VCO2 slope was fitted up to lowest VE/VCO2 ratio, that is, a proxy of the VE/perfusion ratio devoid of nonmetabolic stimuli to ventilatory drive. VE/VCO2 slope tertiles were generated from our database ( (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 9, 2017 Category: Cardiology Authors: Mezzani, A., Giordano, A., Komici, K., Corra, U. Tags: Pathophysiology, Heart Failure, Exercise Testing Original Research Source Type: research

Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation [Arrhythmia and Electrophysiology]
ConclusionsThese novel results suggest that normalization of TT levels after TRT is associated with a significant decrease in the incidence of AF. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 9, 2017 Category: Cardiology Authors: Sharma, R., Oni, O. A., Gupta, K., Sharma, M., , Singh, V., Parashara, D., Kamalakar, S., Dawn, B., Chen, G., Ambrose, J. A., Barua, R. S. Tags: Arrhythmias Original Research Source Type: research

Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress [Heart Failure]
ConclusionsHalofuginone activated the AAR pathway in the heart and attenuated the structural and functional effects of cardiac stress. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 9, 2017 Category: Cardiology Authors: Qin, P., Arabacilar, P., Bernard, R. E., Bao, W., Olzinski, A. R., Guo, Y., Lal, H., Eisennagel, S. H., Platchek, M. C., Xie, W., del Rosario, J., Nayal, M., Lu, Q., Roethke, T., Schnackenberg, C. G., Wright, F., Quaile, M. P., Halsey, W. S., Hughes, A. M Tags: Fibrosis, Heart Failure, Hypertrophy Original Research Source Type: research

Calcification and Oxidative Modifications Are Associated With Progressive Bioprosthetic Heart Valve Dysfunction [Valvular Heart Disease]
BackgroundBioprosthetic heart valves (BHVs), fabricated from glutaraldehyde‐pretreated bovine pericardium or porcine aortic valves, are widely used for the surgical or interventional treatment of heart valve disease. Reoperation becomes increasingly necessary over time because of BHV dysfunction.Methods and ResultsForty‐seven explanted BHV aortic valve replacements were retrieved at reoperation for clinically severe BHV dysfunction over the period 2010–2016. Clinical explant analyses of BHV leaflets for calcium (atomic absorption spectroscopy) and oxidized amino acids, per mass spectroscopy, were primary end points. ...
Source: JAHA:Journal of the American Heart Association - May 8, 2017 Category: Cardiology Authors: Lee, S., Levy, R. J., Christian, A. J., Hazen, S. L., Frick, N. E., Lai, E. K., Grau, J. B., Bavaria, J. E., Ferrari, G. Tags: Valvular Heart Disease, Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Cardiovascular Surgery Original Research Source Type: research

Age-Specific Vascular Risk Factor Profiles According to Stroke Subtype [Stroke]
BackgroundIschemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age.Methods and ResultsWe studied a prospective multicenter university hospital–based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or an...
Source: JAHA:Journal of the American Heart Association - May 8, 2017 Category: Cardiology Authors: Hauer, A. J., Ruigrok, Y. M., Algra, A., van Diȷk, E. J., Koudstaal, P. J., Luiȷckx, G.–J., Nederkoorn, P. J., van Oostenbrugge, R. J., Visser, M. C., Wermer, M. J., Kappelle, L. J., Kliȷn, C. J. M., the Dutch Parelsnoer Instit Tags: Risk Factors, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research