Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets [Coronary Heart Disease]
ConclusionsBased on our findings, we propose that smoking‐associated 5‐HT/catecholamine signaling accelerates the trafficking dynamics of platelets, and this remodels the surface proteins and glycans and predisposes platelets to hyperactive levels. Smokers' platelets also had correspondingly higher resting concentrations of intracellular calcium and transglutaminase activity. These findings suggest a link among smoking, platelet 5‐HT, catecholamine signaling, and their downstream effectors—including phospholipase C and inositol‐1,4,5‐triphosphate pathways—resulting in an increased tonic level of platelet acti...
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Lowery, C. L., Elliott, C., Cooper, A., Hadden, C., Sonon, R. N., Azadi, P., Williams, D. K., Marsh, J. D., Woulfe, D. S., Kilic, F. Tags: Cell Signaling/Signal Transduction, Mechanisms, Platelets, Proteomics, Translational Studies Original Research Source Type: research

Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure [Heart Failure]
ConclusionsIn acute decompensated heart failure patients, an elevated U‐NGAL level on the first day of admission was related to the development of clinical acute kidney injury and independently associated with poor prognosis. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Nakada, Y., Kawakami, R., Matsui, M., Ueda, T., Nakano, T., Takitsume, A., Nakagawa, H., Nishida, T., Onoue, K., Soeda, T., Okayama, S., Watanabe, M., Kawata, H., Okura, H., Saito, Y. Tags: Heart Failure Original Research Source Type: research

Venous Thromboembolism Risk With Antidepressants: Driven by Disease or Drugs? [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: Branchford, B. R. Tags: Clinical Studies, Epidemiology, Mental Health, Thrombosis Editorial Source Type: research

Cardiopulmonary Resuscitation Training Disparities in the United States [Resuscitation Science]
BackgroundBystander cardiopulmonary resuscitation (CPR) is associated with increased survival from cardiac arrest, yet bystander CPR rates are low in many communities. The overall prevalence of CPR training in the United States and associated individual‐level disparities are unknown. We sought to measure the national prevalence of CPR training and hypothesized that older age and lower socioeconomic status would be independently associated with a lower likelihood of CPR training.Methods and ResultsWe administered a cross‐sectional telephone survey to a nationally representative adult sample. We assessed the demographics...
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: Blewer, A. L., Ibrahim, S. A., Leary, M., Dutwin, D., McNally, B., Anderson, M. L., Morrison, L. J., Aufderheide, T. P., Daya, M., Idris, A. H., Callaway, C. W., Kudenchuk, P. J., Vilke, G. M., Abella, B. S. Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care Original Research Source Type: research

Pulse Wave Velocity Predicts Response to Renal Denervation in Isolated Systolic Hypertension [Hypertension]
ConclusionsExtended assessment of arterial stiffness can help improve patient preselection for renal sympathetic denervation and identify a subgroup of isolated systolic hypertension patients who benefit from sympathetic modulation. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: Fengler, K., Rommel, K.-P., Hoellriegel, R., Blazek, S., Besler, C., Desch, S., Schuler, G., Linke, A., Lurz, P. Tags: High Blood Pressure, Treatment Original Research Source Type: research

Force-Sensing Catheters During Pediatric Radiofrequency Ablation: The FEDERATION Study [Pediatric Cardiology]
ConclusionsTactiCath can be effectively employed in the treatment of pediatric patients with congenital heart disease with lower forces than previously described in the atrial fibrillation literature. Patients with atrioventricular nodal reentrant tachycardia or atrioventricular reciprocating tachycardia may not require transmural lesions and the TC may provide surrogate markers for success during slow pathway ablation. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: Dalal, A. S., Nguyen, H. H., Bowman, T., Van Hare, G. F., Avari Silva, J. N. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology Original Research Source Type: research

Impact of Antihypertensive Treatment on Maternal and Perinatal Outcomes in Pregnancy Complicated by Chronic Hypertension: A Systematic Review and Meta–Analysis [Systematic Review and Meta-Analysis]
ConclusionsAntihypertensive treatment reduces the risk of severe hypertension in pregnant women with chronic hypertension. A considerable paucity of data exists to guide choice of antihypertensive agent. Adequately powered head‐to‐head randomized controlled trials of commonly used antihypertensive agents are required to inform prescribing. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: Webster, L. M., Conti-Ramsden, F., Seed, P. T., Webb, A. J., Nelson-Piercy, C., Chappell, L. C. Tags: Pregnancy, Hypertension, Treatment, Meta Analysis Systematic Review and Meta ‐ Source Type: research

Remote Ischemic Perconditioning to Reduce Reperfusion In&&jnodot;nodot;ury During Acute ST–Segment–Elevation Myocardial Infarction: A Systematic Review and Meta–Analysis [Systematic Review and Meta-Analysis]
ConclusionsRIC appears to be a promising adjunctive treatment to PCI for the prevention of reperfusion injury in patients with ST‐segment–elevation myocardial infarction; however, additional high‐quality research is required before a change in practice can be considered. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: McLeod, S. L., Iansavichene, A., Cheskes, S. Tags: Myocardial Infarction, Percutaneous Coronary Intervention, Revascularization, Treatment, Meta Analysis Systematic Review and Meta ‐ Source Type: research

Impact of the Metabolic Syndrome on Mortality is Modified by Objective Short Sleep Duration [Epidemiology]
BackgroundTo examine whether objective sleep duration is an effect modifier of the impact of metabolic syndrome (MetS) on all‐cause and cardiovascular disease/cerebrovascular mortality.Methods and ResultsWe addressed this question in the Penn State Adult Cohort, a random, general population sample of 1344 men and women (48.8±14.2 years) who were studied in the sleep laboratory and followed up for 16.6±4.2 years. MetS was defined by the presence of 3 or more of obesity (≥30 kg/m2), elevated total cholesterol (≥200 mg/dL), triglycerides (≥150 mg/dL), fasting glucose (≥100 mg/dL), and blood pressure (≥130/...
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: Fernandez-Mendoza, J., He, F., LaGrotte, C., Vgontzas, A. N., Liao, D., Bixler, E. O. Tags: Epidemiology, Lifestyle, Risk Factors, Metabolic Syndrome, Mortality/Survival Original Research Source Type: research

Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study [Epidemiology]
BackgroundHeart failure is common in patients with chronic kidney disease. We studied risk factors for incident heart failure among 3557 participants in the CRIC (Chronic Renal Insufficiency Cohort) Study.Methods and ResultsKidney function was assessed by estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C, or both, and 24‐hour urine albumin excretion. During an average of 6.3 years of follow‐up, 452 participants developed incident heart failure. After adjustment for age, sex, race, and clinical site, hazard ratio (95% CI) for heart failure associated with 1 SD lower creatinine‐based eGFR ...
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: He, J., Shlipak, M., Anderson, A., Roy, J. A., Feldman, H. I., Kallem, R. R., Kanthety, R., Kusek, J. W., Ojo, A., Rahman, M., Ricardo, A. C., Soliman, E. Z., Wolf, M., Zhang, X., Raj, D., Hamm, L., for the CRIC (Chronic Renal Insufficiency Cohort) Inves Tags: Epidemiology, Risk Factors, Heart Failure Original Research Source Type: research

Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women [Epidemiology]
ConclusionsUse of antidepressants is common in UK women and is associated with an increased risk of VTE. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: Parkin, L., Balkwill, A., Sweetland, S., Reeves, G. K., Green, J., Beral, V., the Million Women Study Collaborators Tags: Epidemiology, Risk Factors, Embolism, Thrombosis Original Research Source Type: research

How Symptomatic Should a Hypertrophic Obstructive Cardiomyopathy Patient Be to Consider Alcohol Septal Ablation? [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 16, 2017 Category: Cardiology Authors: Jones, B. M., Krishnaswamy, A., Smedira, N. G., Desai, M. Y., Tuzcu, E. M., Kapadia, S. R. Tags: Cardiomyopathy, Hypertrophy, Catheter-Based Coronary and Valvular Interventions, Percutaneous Coronary Intervention Editorial Source Type: research

Weekday and Survival After Cardiac Surgery—A Swedish Nationwide Cohort Study in 106 473 Patients [Cardiovascular Surgery]
ConclusionsWe found no evidence of a clinically relevant weekday effect in patents who underwent cardiac surgery in Sweden during a 15‐year period. These data suggest that the early risk and long‐term prognosis following cardiac surgery was not affected by the weekday of surgery.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02276950. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 16, 2017 Category: Cardiology Authors: Dalen, M., Edgren, G., Ivert, T., Holzmann, M. J., Sartipy, U. Tags: Epidemiology, Cardiovascular Surgery, Mortality/Survival, Quality and Outcomes Original Research Source Type: research

Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry [Arrhythmia and Electrophysiology]
BackgroundThe long‐term efficacy and safety of alcohol septal ablation (ASA) in patients with highly symptomatic hypertrophic obstructive cardiomyopathy has been demonstrated. The aim of this study was to evaluate the long‐term outcomes of mildly symptomatic patients with hypertrophic obstructive cardiomyopathy treated with ASA.Methods and ResultsWe retrospectively evaluated consecutive patients enrolled in the Euro‐ASA registry (1427 patients) and identified 161 patients (53±13 years; 27% women) who were mildly symptomatic (New York Heart Association [NYHA] class II) pre‐ASA. The median (interquartile range) fol...
Source: JAHA:Journal of the American Heart Association - May 16, 2017 Category: Cardiology Authors: Veselka, J., Faber, L., Liebregts, M., Cooper, R., Januska, J., Krejci, J., Bartel, T., Dabrowski, M., Hansen, P. R., Almaas, V. M., Seggewiss, H., Horstkotte, D., Adlova, R., Bundgaard, H., ten Berg, J., Stables, R. H., Jensen, M. K. Tags: Cardiomyopathy, Percutaneous Coronary Intervention, Mortality/Survival Original Research Source Type: research

An Initial Evaluation of the Impact of Pokemon GO on Physical Activity [Health Services and Outcomes Research]
We examined the impact of Pokémon GO on physical activity (PA).Methods and ResultsA pre‐post observational study of 167 Pokémon GO players who were self‐enrolled through recruitment flyers or online social media was performed. Participants were instructed to provide screenshots of their step counts recorded by the iPhone Health app between June 15 and July 31, 2016, which was 3 weeks before and 3 weeks after the Pokémon GO release date. Of 167 participants, the median age was 25 years (interquartile range, 21–29 years). The daily average steps of participants at baseline was 5678 (SD, 2833; median, 5718 [interqu...
Source: JAHA:Journal of the American Heart Association - May 16, 2017 Category: Cardiology Authors: Xian, Y., Xu, H., , Liang, L., Hernandez, A. F., Wang, T. Y., Peterson, E. D. Tags: Exercise, Lifestyle, Primary Prevention, Quality and Outcomes Original Research Source Type: research