JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impact of Coronary Artery Disease Severity Assessed With the SYNTAX Score on Outcomes Following Transcatheter Aortic Valve Replacement [Valvular Heart Disease]
BackgroundThe influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR.Methods and ResultsA total of 377 patients who underwent TAVR in 2 high‐volume centers in North America were included in our retrospective analysis. A blinded angiographic core laboratory calculated the SS on all available coronary angiograms with the use of quantitative coronary analysis. Patients were stratified into 4 groups: (1) no ...
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Paradis, J.–M., White, J. M., Genereux, P., Urena, M., Doshi, D., Nazif, T., Hahn, R., George, I., Khalique, O., Harȷai, K., Lasalle, L., Labbe, B. M., DeLarochelliere, R., Doyle, D., Dumont, E., Mohammadi, S., Leon, M. B., Rodes-Cabau, J., K Tags: Valvular Heart Disease, Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Catheter-Based Coronary and Valvular Interventions, Revascularization Original Research Source Type: research

Dickkopf-3 Ablation Attenuates the Development of Atherosclerosis in ApoE-Deficient Mice [Valvular Heart Disease]
ConclusionsDKK3 expression in macrophages is involved in the pathogenesis of atherosclerosis through modulation of inflammation and inactivation of the Wnt/β‐catenin pathway. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Cheng, W.-L., Yang, Y., Zhang, X.-J., Guo, J., Gong, J., Gong, F.-H., She, Z.-G., Huang, Z., Xia, H., Li, H. Tags: Atherosclerosis, Vascular Disease Original Research Source Type: research

Clinical Outcomes of Remote Ischemic Preconditioning Prior to Cardiac Surgery: A Meta–Analysis of Randomized Controlled Trials [Systematic Review and Meta-Analysis]
ConclusionsRIPC does not reduce morbidity or mortality in patients undergoing cardiac surgery with cardiopulmonary bypass. In the subgroup of studies in which propofol was not used, a reduction in AKI was seen, suggesting that propofol may interact with the protective effects of RIPC. Future studies should evaluate RIPC in the absence of propofol anesthesia. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Pierce, B., Bole, I., Patel, V., Brown, D. L. Tags: Cardiovascular Surgery, Meta Analysis Systematic Review and Meta ‐ Source Type: research

Isosorbide Dinitrate, With or Without Hydralazine, Does Not Reduce Wave Reflections, Left Ventricular Hypertrophy, or Myocardial Fibrosis in Patients With Heart Failure With Preserved Ejection Fraction [Heart Failure]
ConclusionsISDN, with or without hydralazine, does not exert beneficial effects on RM, left ventricular remodeling, or submaximal exercise and is poorly tolerated. ISDN+hydral appears to have deleterious effects on RM, myocardial remodeling, and submaximal exercise. Our findings do not support the routine use of these vasodilators in patients with heart failure with preserved ejection fraction.Clinical Trial RegistrationURL: www.clinicaltrials.gov. Unique identifier: NCT01516346. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Zamani, P., Akers, S., Soto-Calderon, H., Beraun, M., Koppula, M. R., Varakantam, S., Rawat, D., Shiva-Kumar, P., Haines, P. G., Chittams, J., Townsend, R. R., Witschey, W. R., Segers, P., Chirinos, J. A. Tags: Heart Failure, Remodeling Original Research Source Type: research

Comparison of Carotid-Femoral and Brachial-Ankle Pulse-Wave Velocity in Association With Target Organ Damage in the Community-Dwelling Elderly Chinese: The Northern Shanghai Study [Hypertension]
BackgroundCarotid‐femoral pulse‐wave velocity (cf‐PWV) and brachial‐ankle PWV (ba‐PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf‐PWV and ba‐PWV.Methods and ResultsA total of 1599 community‐dwelling elderly subjects (age>65 years) in northern Shanghai were recruited from June 2014 to August 2015. Both cf‐PWV and ba‐PWV were measured using SphygmoCor and VP1000 systems, respectively. Within the framework of comprehensive cardiovascular examinations, risk factors were assessed, and asymptomatic TOD, i...
Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Lu, Y., Zhu, M., Bai, B., Chi, C., Yu, S., Teliewubai, J., Xu, H., Wang, K., Xiong, J., Zhou, Y., Ji, H., Fan, X., Yu, X., Li, J., Blacher, J., Zhang, Y., Xu, Y. Tags: Epidemiology Original Research Source Type: research

Routine Predeployment Balloon Aortic Valvuloplasty During Transcatheter Aortic Valve Replacement: Time to Move On? [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 18, 2017 Category: Cardiology Authors: Poulin, M.-F., Kavinsky, C. J. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Editorial Source Type: research

Pre-Implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry [Valvular Heart Disease]
ConclusionsPerforming TAVI without predilation was not associated with adverse short‐term outcomes post procedure, especially when using a balloon‐expandable prosthesis. Randomized trials including different valve types are required to provide conclusive evidence regarding the utility of predilation before‐TAVI. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 18, 2017 Category: Cardiology Authors: Martin, G. P., Sperrin, M., Bagur, R., de Belder, M. A., Buchan, I., Gunning, M., Ludman, P. F., Mamas, M. A. Tags: Aortic Valve Replacement/Transcatheter Aortic Valve Implantation Original Research Source Type: research

Cost-Effectiveness of Intensifying Lipid-Lowering Therapy With Statins Based on Individual Absolute Benefit in Coronary Artery Disease Patients [Vascular Medicine]
ConclusionsIntensive LLT with statins for all coronary artery disease patients results in the highest overall QALY gain against acceptable costs. However, the number of QALYs gained with intensive LLT by statins in individual patients can be increased with selective benefit‐based treatment.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifiers: NCT00327691 and NCT00159835 (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 18, 2017 Category: Cardiology Authors: Stam-Slob, M. C., van der Graaf, Y., Greving, J. P., Dorresteiȷn, J. A. N., Visseren, F. L. J. Tags: Secondary Prevention, Cost-Effectiveness, Quality and Outcomes, Coronary Artery Disease Original Research Source Type: research

Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest [Resuscitation Science]
ConclusionsThe absorption of ETT epinephrine is low and delayed at birth. RA and low UVC epinephrine rapidly achieve high plasma concentrations resulting in ROSC. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 18, 2017 Category: Cardiology Authors: Vali, P., Chandrasekharan, P., Rawat, M., Gugino, S., Koenigsknecht, C., Helman, J., Jusko, W. J., Mathew, B., Berkelhamer, S., Nair, J., Wyckoff, M. H., Lakshminrusimha, S. Tags: Arrhythmias, Animal Models of Human Disease, Cardiopulmonary Resuscitation and Emergency Cardiac Care, Cardiopulmonary Arrest Original Research Source Type: research

Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction [Heart Failure]
BackgroundSoluble suppression of tumorigenicity 2 (sST2) receptor is a biomarker that is elevated in certain systemic inflammatory diseases. Comorbidity‐driven microvascular inflammation is postulated to play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology, but data on how sST2 relates to clinical characteristics or inflammatory conditions or biomarkers in HFpEF are limited. We sought to determine circulating levels and clinical correlates of sST2 in HFpEF.Methods and ResultsAt enrollment, patients (n=174) from the Phosphodiesterase‐5 Inhibition to Improve Clinical Status And Exerci...
Source: JAHA:Journal of the American Heart Association - February 18, 2017 Category: Cardiology Authors: AbouEzzeddine, O. F., McKie, P. M., Dunlay, S. M., Stevens, S. R., Felker, G. M., Borlaug, B. A., Chen, H. H., Tracy, R. P., Braunwald, E., Redfield, M. M. Tags: Biomarkers, Clinical Studies, Heart Failure Original Research Source Type: research

Trends in Coronary Revascularization and Ischemic Heart Disease-Related Mortality in Israel [Vascular Medicine]
BackgroundWe investigated national trends in volume and outcomes of percutaneous coronary angioplasty (PCI), coronary artery bypass grafting (CABG), and ischemic heart disease–related mortality in Israel.Methods and ResultsUsing International Classification of Diseases 9th and 10th revision codes, we linked 5 Israeli national databases, including the Israel Center for Disease Control National PCI and CABG Registries, the Ministry of Health Hospitalization Report, the Center of Bureau of Statistics, and the Ministry of Interior Mortality Report, to assess the annual PCI and CABG volume, procedural mortality, comorbidities...
Source: JAHA:Journal of the American Heart Association - February 17, 2017 Category: Cardiology Authors: Blumenfeld, O., Na'amnih, W., Shapira-Daniels, A., Lotan, C., Shohat, T., Shapira, O. M. Tags: Cardiovascular Disease, Cardiovascular Surgery, Catheter-Based Coronary and Valvular Interventions, Mortality/Survival Original Research Source Type: research

Vinexin {beta} Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor {kappa}B Inflammatory Axis [Valvular Heart Disease]
ConclusionsVinexin β deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt–nuclear factor κB signaling. Our data suggest that vinexin β could be a therapeutic target for the treatment of atherosclerosis. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 16, 2017 Category: Cardiology Authors: Guan, H., Cheng, W.-L., Guo, J., Chao, M.-L., Zhang, Y., Gong, J., Zhu, X.-Y., She, Z.-G., Huang, Z., Li, H. Tags: Atherosclerosis, Vascular Disease Original Research Source Type: research

Thrombus Migration in the Middle Cerebral Artery: Incidence, Imaging Signs, and Impact on Success of Endovascular Thrombectomy [Stroke]
ConclusionsPreinterventional TM does not seem to be facilitated by intravenous recombinant tissue plasminogen activator and often occurs spontaneously. However, TM is associated with the risk of incomplete reperfusion in subsequent thrombectomy, suggesting increased clot fragility. Occurrence of TM may thereby have a substantial impact on the outcome of endovascularly treated stroke patients. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 15, 2017 Category: Cardiology Authors: Kaesmacher, J., Maegerlein, C., Kaesmacher, M., Zimmer, C., Poppert, H., Friedrich, B., Boeckh-Behrens, T., Kleine, J. F. Tags: Revascularization, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Research Source Type: research

Association of Morning Hypertension Subtype With Vascular Target Organ Damage and Central Hemodynamics [Hypertension]
BackgroundA recent study reported that morning hypertension is associated with poor cardiovascular outcomes in hypertensive patients. However, it is unclear whether morning hypertension associated with sustained nocturnal hypertension and that associated with morning blood pressure (BP) surge differ in terms of their effects on cardiovascular target organ damage and clinical outcomes. The present study aimed to determine the association of morning hypertension with/without nocturnal hypertension with vascular target organ damage and central hemodynamics in patients at high risk for cardiovascular disease.Methods and Result...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Oh, J., Lee, C. J., Kim, I.-C., Lee, S.-H., Kang, S.-M., Choi, D., Park, S., Kario, K. Tags: Hypertension Original Research Source Type: research

Comparison of Carotid Plaque Score and Coronary Artery Calcium Score for Predicting Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis [Epidemiology]
BackgroundCoronary artery calcium (CAC) predicts coronary heart disease (CHD) events better than carotid wall plaque presence; however, differences in the utility of CAC burden and carotid plaque burden across the spectrum of cardiovascular disease (CVD) events is unknown.Methods and ResultsCVD, CHD and stroke/transient ischemic attack (TIA) events were evaluated prospectively in a multiethnic cohort without CVD at baseline. Carotid plaque score was determined by the number of ultrasound‐detected plaques in the common, bifurcation, and internal carotid artery segments. CAC was detected by computed tomography. Predictive ...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Gepner, A. D., Young, R., Delaney, J. A., Budoff, M. J., Polak, J. F., Blaha, M. J., Post, W. S., Michos, E. D., Kaufman, J., Stein, J. H. Tags: Epidemiology, Primary Prevention, Risk Factors, Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) Original Research Source Type: research