Physical Activity and Sedentary Behavior in Children With Congenital Heart Disease [Congenital Heart Disease]
ConclusionsWe found normal age–sex patterns of PA in children with CHD. There were no differences in PA by CHD severity, suggesting that sociocultural factors are likely important determinants of PA in these children. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 6, 2017 Category: Cardiology Authors: Voss, C., Duncombe, S. L., Dean, P. H., de Souza, A. M., Harris, K. C. Tags: Exercise, Pediatrics, Congenital Heart Disease Original Research Source Type: research

Adipocyte-Specific Enhancement of Angiotensin II Type 1 Receptor-Associated Protein Ameliorates Diet-Induced Visceral Obesity and Insulin Resistance [Hypertension]
ConclusionsResults presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet‐induced visceral obesity and insulin resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling. Consequently, adipose tissue ATRAP is suggested to be an effective therapeutic target for the treatment of visceral obesity. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 6, 2017 Category: Cardiology Authors: Azushima, K., Ohki, K., Wakui, H., Uneda, K., Haku, S., Kobayashi, R., Haruhara, K., Kinguchi, S., Matsuda, M., Maeda, A., Toya, Y., Yamashita, A., Umemura, S., Tamura, K. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Animal Models of Human Disease, Diabetes, Type 2, Obesity Original Research Source Type: research

Incident Coronary Heart Disease After Preeclampsia: Role of Reduced Fetal Growth, Preterm Delivery, and Parity [Epidemiology]
ConclusionsThe occurrence of major coronary events was increased among women with preeclampsia and highest for preeclampsia combined with a child born small for gestational age and/or preterm delivery. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 6, 2017 Category: Cardiology Authors: Riise, H. K. R., Sulo, G., Tell, G. S., Igland, J., Nygard, O., Vollset, S. E., Iversen, A.–C., Austgulen, R., Daltveit, A. K. Tags: Cardiovascular Disease, Epidemiology, Pregnancy, Risk Factors, Women Original Research Source Type: research

Implantable Cardioverter-Defibrillators for Secondary Prevention of Sudden Cardiac Death: A Review [Contemporary Review]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 3, 2017 Category: Cardiology Authors: Borne, R. T., Katz, D., Betz, J., Peterson, P. N., Masoudi, F. A. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Sudden Cardiac Death Contemporary Review Source Type: research

Transcatheter Heart Valve Selection and Permanent Pacemaker Implantation in Patients With Pre-Existent Right Bundle Branch Block [Interventional Cardiology]
ConclusionsRight bundle branch block at baseline is associated with a high incidence of PPM implantation for all transcatheter heart valves. PPM rate was highest for Lotus and lowest for ES‐XT and ES‐3. Pacemaker dependency remained high during follow‐up. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 3, 2017 Category: Cardiology Authors: van Gils, L., Tchetche, D., Lhermusier, T., Abawi, M., Dumonteil, N., Rodriguez Olivares, R., Molina-Martin de Nicolas, J., Stella, P. R., Carrie, D., De Jaegere, P. P., Van Mieghem, N. M. Tags: Valvular Heart Disease, Electrocardiology (ECG), Aortic Valve Replacement/Transcatheter Aortic Valve Implantation, Catheter-Based Coronary and Valvular Interventions Original Research Source Type: research

Clinical Impact and Costs of Echocardiographic Screening for Rheumatic Heart Disease [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 2, 2017 Category: Cardiology Authors: Kirkpatrick, J. N., Otto, C. M. Tags: Echocardiography, Cost-Effectiveness, Quality and Outcomes Editorial Source Type: research

Renal Denervation Therapy for the Treatment of Arrhythmias: Is the Sky the Limit? [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 2, 2017 Category: Cardiology Authors: Bhave, P. D. Tags: Arrhythmias Editorial Source Type: research

Frequency Gradient Within Coronary Sinus Predicts the Long-Term Outcome of Persistent Atrial Fibrillation Catheter Ablation [Arrhythmia and Electrophysiology]
BackgroundThe coronary sinus (CS), as a junction of the atria, contributes to atrial fibrillation (AF) by developing unstable reentry, and isolating the atria by ablation at the CS could terminate AF. The present study evaluated whether AF activities at the CS in a subset of patients contributed to AF maintenance and predicted clinical outcome of ablation.Methods and ResultsWe studied 122 consecutive patients who had a first‐time radiofrequency ablation for persistent AF. Bipolar electrograms were obtained from multiple regions of the left atrium by a Lasso mapping catheter before ablation. Pulmonary vein isolation termi...
Source: JAHA:Journal of the American Heart Association - March 2, 2017 Category: Cardiology Authors: Yin, X., Zhao, Z., Gao, L., Chang, D., Xiao, X., Zhang, R., Chen, Q., Cheng, J., Yang, Y., Xi, Y., Xia, Y. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Clinical Studies Original Research Source Type: research

Impacts of Renal Sympathetic Activation on Atrial Fibrillation: The Potential Role of the Autonomic Cross Talk Between Kidney and Heart [Arrhythmia and Electrophysiology]
ConclusionsThis study demonstrated that renal sympathetic nerve activation induced by 3 hours of P‐RSS facilitated atrial fibrillation inducibility by upregulating cardiac autonomic nervous activity, suggesting a potential autonomic cross talk between kidney and heart. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 2, 2017 Category: Cardiology Authors: Yu, L., Huang, B., Wang, Z., Wang, S., Wang, M., Li, X., Zhou, L., Meng, G., Yuan, S., Zhou, X., Jiang, H. Tags: Atrial Fibrillation, Autonomic Nervous System Original Research Source Type: research

Echocardiographic Screening for Rheumatic Heart Disease in Indigenous Australian Children: A Cost-Utility Analysis [Valvular Heart Disease]
ConclusionsEchocardiographic screening for RHD is cost‐effective in our context, assuming that RHD can be detected ≥2 years earlier by screening. Our model can be adapted to any other setting but will require local data or acceptable assumptions for model parameters. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 2, 2017 Category: Cardiology Authors: Roberts, K., Cannon, J., Atkinson, D., Brown, A., Maguire, G., Remenyi, B., Wheaton, G., Geelhoed, E., Carapetis, J. R. Tags: Pediatrics, Rheumatic Heart Disease, Valvular Heart Disease, Echocardiography, Cost-Effectiveness Original Research Source Type: research

Beneficial Effect of Renal Denervation on Ventricular Premature Complex Induced Cardiomyopathy [Arrhythmia and Electrophysiology]
This study aimed to investigate the effect of frequent VPCs on structural and electrical properties and whether RDN can protect the heart from remodeling.Methods and ResultsEighteen rabbits were randomized to control (n=6), VPC (n=6), and VPC‐RDN (n=6) groups. Surgical and chemical RDNs were approached through bilateral retroperitoneal flank incisions in the VPC‐RDN group. Pacemakers were implanted to the left ventricular apex to produce 50% VPC burden for 5 weeks in the VPC and VPC‐RDN groups. In addition, ventricular myocardium was harvested for western blot and trichrome stain. Echocardiographic results showed le...
Source: JAHA:Journal of the American Heart Association - March 2, 2017 Category: Cardiology Authors: Yamada, S., Lo, L.-W., Chou, Y.-H., Lin, W.-L., Chang, S.-L., Lin, Y.-J., Liu, S.-H., Cheng, W.-H., Tsai, T.-Y., Chen, S.-A. Tags: Arrhythmias, Animal Models of Human Disease Original Research Source Type: research

Rheumatic Heart Disease Severity, Progression and Outcomes: A Multi-State Model [Valvular Heart Disease]
ConclusionsThe prognosis of young Indigenous Australians diagnosed with severe RHD is bleak; interventions must focus on earlier detection and treatment if the observed natural history is to be improved. This multi‐state model can be used to predict the effect of different interventions on disease progression and the associated costs. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 2, 2017 Category: Cardiology Authors: Cannon, J., Roberts, K., Milne, C., Carapetis, J. R. Tags: Heart Failure, Rheumatic Heart Disease, Valvular Heart Disease, Echocardiography, Mortality/Survival Original Research Source Type: research

Time in Therapeutic Range and Outcomes After Warfarin Initiation in Newly Diagnosed Atrial Fibrillation Patients With Renal Dysfunction [Kidney in Cardiovascular Disease]
BackgroundIt is unknown whether renal dysfunction conveys poor anticoagulation control in warfarin‐treated patients with atrial fibrillation and whether poor anticoagulation control associates with the risk of adverse outcomes in these patients.Methods and ResultsThis was an observational study from the Stockholm CREatinine Measurements (SCREAM) cohort including all newly diagnosed atrial fibrillation patients initiating treatment with warfarin (n=7738) in Stockholm, Sweden, between 2006 and 2011. Estimated glomerular filtration rate (eGFR; mL/min per 1.73 m2) was calculated from serum creatinine. Time‐in‐therapeuti...
Source: JAHA:Journal of the American Heart Association - March 1, 2017 Category: Cardiology Authors: Szummer, K., Gasparini, A., Eliasson, S., Arnlov, J., Qureshi, A. R., Barany, P., Evans, M., Friberg, L., Carrero, J. J. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Cardiovascular Disease, Anticoagulants, Intracranial Hemorrhage, Ischemic Stroke Original Research Source Type: research

Efficacy of Prophylactic Dexmedetomidine in Preventing Postoperative Junctional Ectopic Tachycardia After Pediatric Cardiac Surgery [Arrhythmia and Electrophysiology]
BackgroundPostoperative junctional ectopic tachycardia is one of the most serious arrhythmias that occur after pediatric cardiac surgery, difficult to treat and better to be prevented. Our aim was to assess the efficacy of prophylactic dexmedetomidine in preventing junctional ectopic tachycardia after pediatric cardiac surgery.Methods and ResultsA prospective controlled study was carried out on 90 children who underwent elective cardiac surgery for congenital heart diseases. Patients were randomized into 2 groups. Group I (dexmedetomidine group): 60 patients received dexmedetomidine; Group II (Placebo group): 30 patients r...
Source: JAHA:Journal of the American Heart Association - March 1, 2017 Category: Cardiology Authors: El Amrousy, D. M., Elshmaa, N. S., El-Kashlan, M., Hassan, S., Elsanosy, M., Hablas, N., Elrifaey, S., El-Feky, W. Tags: Arrhythmias, Cardiopulmonary Resuscitation and Emergency Cardiac Care Original Research Source Type: research

Cardiovascular Disease and Patterns of Change in Functional Status Over 15 Years: Findings From the Atherosclerosis Risk in Communities (ARIC) Study [Epidemiology]
ConclusionsThis study documents that a decline in FS precedes incidence of CVD‐related hospitalization by at least 2 years, providing a strong argument for routine preventative assessment of FS among older adults. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 1, 2017 Category: Cardiology Authors: Kucharska-Newton, A., Griswold, M., Yao, Z. H., Foraker, R., Rose, K., Rosamond, W., Wagenknecht, L., Koton, S., Pompeii, L., Windham, B. G. Tags: Cardiovascular Disease, Epidemiology, Primary Prevention, Women Original Research Source Type: research