JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Sex- and Race-Related Differences in Characteristics and Outcomes of Hospitalizations for Heart Failure With Preserved Eȷection Fraction [Heart Failure]
ConclusionsDifferences in patient characteristics and outcomes reinforce the notion that sex and race contribute to the phenotypic heterogeneity of HFpEF. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 29, 2017 Category: Cardiology Authors: Goyal, P., Paul, T., Almarzooq, Z. I., Peterson, J. C., Krishnan, U., Swaminathan, R. V., Feldman, D. N., Wells, M. T., Karas, M. G., Sobol, I., Maurer, M. S., Horn, E. M., Kim, L. K. Tags: Heart Failure, Mortality/Survival Original Research Source Type: research

{beta}-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55{alpha}-PP2A-Mediated Dephosphorylation [Molecular Cardiology]
Conclusionsβ‐AR stimulation induces HDAC5 nuclear accumulation in cardiomyocytes by a mechanism that is protein kinase A‐dependent but requires B55α‐PP2A‐mediated dephosphorylation of Ser259/Ser498 rather than protein kinase A‐mediated phosphorylation of Ser279. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 25, 2017 Category: Cardiology Authors: Weeks, K. L., Ranieri, A., Karaś, A., Bernardo, B. C., Ashcroft, A. S., Molenaar, C., McMullen, J. R., Avkiran, M. Tags: Basic Science Research, Cell Signaling/Signal Transduction, Mechanisms, Myocardial Biology, Hypertrophy Original Research Source Type: research

An NPPB Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality [Genetics]
ConclusionsThe rs198389 G allele in the NPPB promoter is associated with elevated levels of NT‐proBNP throughout adult life, reduced blood pressure, hypertension and cardiovascular mortality, and increased lifespan. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 24, 2017 Category: Cardiology Authors: Seidelmann, S. B., Vardeny, O., Claggett, B., Yu, B., Shah, A. M., Ballantyne, C. M., Selvin, E., MacRae, C. A., Boerwinkle, E., Solomon, S. D. Tags: Risk Factors, Genetic, Association Studies, Hypertension, Blood Pressure, Mortality/Survival Original Research Source Type: research

Monocrotaline Induces Endothelial Inȷury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor [Hypertension]
ConclusionsMonocrotaline aggregates on and activates the CaSR of pulmonary artery endothelial cells to trigger endothelial damage and, ultimately, induces pulmonary hypertension. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 22, 2017 Category: Cardiology Authors: Xiao, R., Su, Y., Feng, T., Sun, M., Liu, B., Zhang, J., Lu, Y., Li, J., Wang, T., Zhu, L., Hu, Q. Tags: Animal Models of Human Disease, Basic Science Research, Cell Signaling/Signal Transduction, Vascular Biology Original Research Source Type: research

Warning About Shortcuts in Drug Development [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 21, 2017 Category: Cardiology Authors: Califf, R. M. Tags: Biomarkers, Ethics and Policy Editorial Source Type: research

Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990-2011 [Health Services and Outcomes Research]
ConclusionsAlthough cardiovascular surrogate outcomes trials frequently show superiority of the tested intervention, they are infrequently followed by a prominent outcomes trial. When there was a high‐profile clinical outcomes study, nearly half of the positive surrogate trials were not validated. Cardiovascular surrogate outcome trials may be more appropriate for excluding benefit from the patient perspective than for identifying it. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 21, 2017 Category: Cardiology Authors: Bikdeli, B., Punnanithinont, N., Akram, Y., Lee, I., Desai, N. R., Ross, J. S., Krumholz, H. M. Tags: Quality and Outcomes Original Research Source Type: research

Sex and Outcomes After Percutaneous Coronary Intervention: A Cause for Concern for Young Women and Those With ST-Segment Elevation Myocardial Infarction? [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Tamis-Holland, J. E. Tags: Catheter-Based Coronary and Valvular Interventions, Complications, Mortality/Survival, Quality and Outcomes Editorial Source Type: research

Metabolic Mediators of the Effects of Family History and Genetic Risk Score on Coronary Heart Disease—Findings From the Malmo Diet and Cancer Study [Coronary Heart Disease]
ConclusionsA fraction of the CHD risk associated with family history or with GRS50 is mediated through elevated blood lipids and hypertension, but not through diabetes mellitus. However, a major part (≥80%) of the genetic effect operates independently of established metabolic risk factor pathways. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Fritz, J., Shiffman, D., Melander, O., Tada, H., Ulmer, H. Tags: Epidemiology, Risk Factors, Genetics, Coronary Artery Disease Original Research Source Type: research

Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Are Associated With Improved Outcome but Do Not Prevent New-Onset Atrial Fibrillation After Acute Myocardial Infarction [Coronary Heart Disease]
ConclusionsRAS inhibition post‐AMI was associated with lower risk of all‐cause mortality. In patients with/without CHF, RAS inhibition was not associated with lower incidence of new‐onset AF. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Batra, G., Lindhagen, L., Andell, P., Erlinge, D., James, S., Spaak, J., Oldgren, J. Tags: Arrhythmias, ACE/Angiotensin Receptors/Renin Angiotensin System, Acute Coronary Syndromes Original Research Source Type: research

Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology [Coronary Heart Disease]
ConclusionsDespite identical technical success rates of PCI between the 2 sexes, women with PCI for ST elevation myocardial infarction have a 20% higher age‐adjusted risk of death and of ischemic cardiac and cerebrovascular events. Further research is needed to determine the reasons for these differences. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Heer, T., Hochadel, M., Schmidt, K., Mehilli, J., Zahn, R., Kuck, K.–H., Hamm, C., Bohm, M., Ertl, G., Hoffmeister, H. M., Sack, S., Senges, J., Massberg, S., Gitt, A. K., Zeymer, U. Tags: Cardiovascular Disease, Women, Percutaneous Coronary Intervention, Stent, Treatment Original Research Source Type: research

Association of Husband Smoking With Wife's Hypertension Status in Over 5 Million Chinese Females Aged 20 to 49 Years [Hypertension]
This study included 5 027 731 females along with their husbands from the National Free Pre‐pregnancy Checkup Projects conducted across 31 provinces in China in 2014. Smoking/passive smoking status was collected by a standard questionnaire and blood pressure was measured by an electronic device after 10 minutes rest. Odds ratios and their corresponding 95% CIs for female hypertension were estimated according to smoking status of husband and wife, husbands' smoking amount, and cumulative exposure to husband smoking. Compared with neither‐smoker group, the multivariable‐adjusted odds ratio for female hypertension was...
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Yang, Y., Liu, F., Wang, L., Li, Q., Wang, X., Chen, J. C., Wang, Q., Shen, H., Zhang, Y., Yan, D., Zhang, M., He, Y., Peng, Z., Wang, Y., Xu, J., Zhao, J., , Zhang, H., Xin, X., , Liu, D., Guo, T., Dai, Q., Ma, X. Tags: Epidemiology, Lifestyle, Risk Factors, Women, Hypertension Original Research Source Type: research

Association of Cardiovascular Health With Subclinical Disease and Incident Events: The Multi-Ethnic Study of Atherosclerosis [Epidemiology]
ConclusionsThere is a graded inverse association between CVH scores and measures of subclinical and overt cardiovascular disease that is similar across race/ethnic groups. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Polonsky, T. S., Ning, H., Daviglus, M. L., Liu, K., Burke, G. L., Cushman, M., Eng, J., Folsom, A. R., Lutsey, P. L., Nettleton, J. A., Post, W. S., Sacco, R. L., Szklo, M., Lloyd-Jones, D. M. Tags: Epidemiology, Lifestyle, Primary Prevention, Race and Ethnicity, Vascular Disease Original Research Source Type: research

Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction [Heart Failure]
BackgroundProlonged QRS duration is associated with increased mortality among heart failure patients, but race or sex differences in QRS duration and associated effect on outcomes are unknown.Methods and ResultsWe investigated QRS duration and morphology among 2463 black and white patients with heart failure and left ventricular ejection fraction ≤35% who underwent coronary angiography and 12‐lead electrocardiography at Duke University Hospital from 1995 through 2011. We used multivariable Cox regression models to assess the relationship between QRS duration and all‐cause mortality and investigate race‐QRS and sex�...
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Randolph, T. C., Broderick, S., Shaw, L. K., Chiswell, K., Mentz, R. J., Kutyifa, V., Velazquez, E. J., Gilliam, F. R., Thomas, K. L. Tags: Electrophysiology, Race and Ethnicity, Women, Heart Failure, Mortality/Survival Original Research Source Type: research

Statin Use and the Risk of Cataracts: A Systematic Review and Meta–Analysis [Systematic Review and Meta-Analysis]
ConclusionsBased on the present meta‐analysis of these studies, we could only conclude that there is no clear evidence showing that statin use increases the risk of cataracts. The most likely case is that there is no association between statin use and cataracts. Because of the considerable benefits of statins in cardiovascular patients, this issue should not deter their use. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Yu, S., Chu, Y., Li, G., Ren, L., Zhang, Q., Wu, L. Tags: Meta Analysis Systematic Review and Meta ‐ Source Type: research

Early Invasive Strategy and In-Hospital Survival Among Diabetics With Non-ST-Elevation Acute Coronary Syndromes: A Contemporary National Insight [Coronary Heart Disease]
BackgroundThere are limited data on the merits of an early invasive strategy in diabetics with non‐ST‐elevation acute coronary syndrome, with unclear influence of this strategy on survival. The aim of this study was to evaluate the in‐hospital survival of diabetics with non‐ST‐elevation acute coronary syndrome treated with an early invasive strategy compared with an initial conservative strategy.Methods and ResultsThe National Inpatient Sample database, years 2012–2013, was queried for diabetics with a primary diagnosis of non‐ST‐elevation acute coronary syndrome defined as either non‐ST‐elevation myoca...
Source: JAHA:Journal of the American Heart Association - March 18, 2017 Category: Cardiology Authors: Mahmoud, A. N., Elgendy, I. Y., Mansoor, H., Wen, X., Mojadidi, M. K., Bavry, A. A., Anderson, R. D. Tags: Catheter-Based Coronary and Valvular Interventions, Percutaneous Coronary Intervention, Revascularization, Mortality/Survival, Coronary Artery Disease Original Research Source Type: research