A nucleic acid amplification repeat testing algorithm reveals high risk of hepatitis B and C transmission with serologic blood screening practice in Punjab, India
ISBT Science Series, EarlyView. (Source: ISBT Science Series)
Source: ISBT Science Series - November 8, 2017 Category: Hematology Source Type: research

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ISBT Science Series, Ahead of Print. (Source: ISBT Science Series)
Source: ISBT Science Series - November 8, 2017 Category: Hematology Source Type: research

Issue Information
(Source: ISBT Science Series)
Source: ISBT Science Series - November 7, 2017 Category: Hematology Tags: Issue Information Source Type: research

Major applications and limitations of blood group genotyping in China
Molecular immunohematological techniques have been well applied in the transfusion medicine. Here, we review the major applications for blood group genotyping in China. Its application mainly focuses on the typing of blood group antigens in complex cases, such as ABO subgroups, D variants or the Asian specific and common antigens typing (such as the antigens expressed by the MNS hybrid glycophorins), also because of lacking of the corresponding commercial antibodies. The comprehensive antigens profile in some specific samples could be obtained using medium‐ or high‐throughput genotyping platforms. Although, foetal RHD ...
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: Y. L. Ji Tags: Congress Review Source Type: research

Quality monitoring and risk management in blood transfusion services
This study discusses several aspects of quality monitoring and risk management including their role, the importance thereof, objectives and implementation strategies. Quality monitoring is elaborated in detail with regard to quality indicators and quality control of blood components. In addition to describing general aspects of risk management in transfusion medicine, an example of its application is given on labelling of blood and blood components using the format of the EuBIS guide. Considering the biological origin of blood components and specific risks associated with their use, activities of quality monitoring and ris...
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: T. Vuk, Y. Qiu, L. Bust, P. Strengers, C. Seidl Tags: Congress Review Source Type: research

Hepatitis C: from discovery to cure
ConclusionThe battle against hepatitis C is destined to be recorded in history as one of science's remarkable success. Although the revolutionary direct‐antiviral agents (DAAs) are able to cure more than 95% of HCV patients, access to diagnosis and therapy remains improved. More efforts should be made to promote HCV screening, treatment delivery and vaccine development. (Source: ISBT Science Series)
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: Y. Li, S. Li, X. Duan, C. Yang, M. Xu, L. Chen Tags: Congress Review Source Type: research

Multifaceted regenerative lives of ‘expired’ platelets
In conclusion, there is a scientific rationale for making optimal use of expired platelets to produce standardized growth factor preparations for both cell therapy procedures and dedicated regenerative medicine applications. (Source: ISBT Science Series)
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: T. Burnouf Tags: Congress Review Source Type: research

Transfusion leadership in the hospital
The hospital environment, across multidisciplinary transfusion processes, is complex involving various organizations and agencies, staff and patients. A comprehensive, robust, collaborative, inclusive and effective clinical governance framework for transfusion/blood management activities is essential for patient safety and optimal outcomes; this should include integrated systems across the transfusion chain which is intrinsically high risk, given the possible severe adverse outcomes of error, multiple potential vulnerabilities and various components not being supported by electronic systems. Strong, informed clinician lead...
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: M. Cole ‐Sinclair, A. Wynne, L. Maddy Tags: Congress Review Source Type: research

Correcting preoperative iron deficiency as part of patient blood management in the ‘real world’: results of an audit on an Australian cohort
ConclusionPreoperative iron therapy was associated with reduced need for postoperative red blood cell transfusion in elective major surgery patients who were initially iron deficient. (Source: ISBT Science Series)
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: F. S. Hong, N. Sieradzki, C. Pollock, F. Nasra, L. Churilov, A. Mo, A. Willcox, W. K. Ho, C. Smith Tags: Original Article Source Type: research

Identification and correction of human errors in real ‐time – a blood banking surveillance system
ConclusionAuto‐generated alerts on interception of human errors in real‐time eliminate bias of under‐reporting due to human dependent surveillance systems, thus, providing a better representation of the range of human errors in the blood bank and transfusions. The BBMIS was able to intercept errors at inception, halting further processing and prompting the user to take corrective actions, thus, enabling correction of all errors in the studied categories. (Source: ISBT Science Series)
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: Saba Jamal, Isra Shaikh, Shomaila Sohail, Uzma Ata, Aamir Saeed, Shazia Saleem Tags: Original Paper Source Type: research

Basic aspects, application and platforms currently available for molecular blood grouping of donor and patient population
The majority of allelic variants conferring red cell blood group antigens are attributable to single nucleotide polymorphisms, which are immensely amenable to routine genotyping methods such as PCR‐RFLP, SSP, SSO and fluorescent‐based real‐time PCR assays. These techniques are feasible in a low‐ to medium‐throughput setting. Multiplexing and use of solid surfaces or beads for probe capture have further improved the throughput and turnaround time allowing multiple alleles to be interrogated simultaneously. Novel approaches, as in the use of MALDI‐TOF mass spectrometry, appear as an attractive option for accurate...
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: V. Nadarajan Tags: Congress Review Source Type: research

A clinical trial of frozen platelets: rationale, protocol and pilot analysis plan
ConclusionsIntroduction of a novel blood component for a clinical trial has posed many challenges, which have been overcome. Upon completion, data will be used to inform the design and sample size calculations for a larger definitive trial. (Source: ISBT Science Series)
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: D. C. Marks, L. Johnson, M. C. Reade Tags: Congress Review Source Type: research

Transfusion education for nurses and transfusion practitioners in Australia
ConclusionEducation is fundamental to ensure that staff working in the area of transfusion/PBM have the knowledge and understanding to provide high‐quality, effective and safe patient care. It is an ongoing process, requiring regular updates and reinforcement to keep pace with changes to reduce errors and risk and improve patient outcomes. (Source: ISBT Science Series)
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: L. Bielby, D. Peterson, T. Spigiel Tags: Congress Review Source Type: research

Applications for kodecytes in immunohaematology
Red cells used in immunohaematology are mostly limited to those that nature provides. Very few techniques are available for adding new functionalities to cells, without affecting their intrinsic functionality or vitality. Kode Technology is a surface modification technology that uses amphipathic function‐spacer‐lipid constructs to rapidly and harmlessly attach bioactive material to cell surfaces (creating kodecytes) and nonbiological surfaces (koded surfaces). Originally designed to attach blood group glycans onto red blood cells for quality control use, the technology has since expanded to modification of any type of ...
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: S. Henry, H. Perry, N. Bovin Tags: Congress Review Source Type: research

Bleeding or no bleeding? Anti ‐endothelial alphaVbeta3 antibodies as a major cause of intracranial haemorrhage in fetal–neonatal alloimmune thrombocytopenia
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a severe bleeding disorder which can result in intracranial haemorrhage (ICH), leading to death or neurological sequelae. In Caucasians, maternal anti‐HPA‐1a antibodies (abs) are responsible for the majority of FNAIT cases. However, the correlation between fetal platelet counts and risk of bleeding is loose. ICH was also observed in FNAIT cases with platelet counts within reference ranges. These observations question the exclusive role of thrombocytopenia in ICH. Recently, we observed stronger binding of anti‐HPA‐1a antibodies from mothers with ICH‐positive (+...
Source: ISBT Science Series - November 1, 2017 Category: Hematology Authors: U. J. Sachs, S. Santoso Tags: Congress Review Source Type: research