Wilde’s worlds: Sir William Wilde in Victorian Ireland
Conclusions A variety of close British Isles parallels can be drawn between Wilde and his cohort in the medical elite of Dublin and their clinical peers in Edinburgh and London both in terms of clinical practice and self-presentation and in terms of the social and political challenges facing their respective ancient regime hegemonies in an age of democratic radicalisation. The shared ideological interests of Wilde and his cohort, however, were also challenged by the socio-political particularities and complexities of Ireland during the first half of the nineteenth century culminating in the catastrophe of the Gre...
Source: Irish Journal of Medical Science - March 18, 2016 Category: Journals (General) Source Type: research

William Wilde in the West of Ireland
Abstract It is widely believed that Sir William Wilde’s forebears were in Ireland for just two or three generations. This belief stems from a number of short biographies of Wilde which were published during his lifetime. These biographies gave different versions of the origin of the Wilde family and appear to have been generated by the creative imagination of Lady Jane Wilde or, as she was better known by her nom de plume, Speranza. She was equally imaginative in creating narratives about her own family background and in one she claimed descent from the Italian poet Dante Alighieri. So it was not a great cha...
Source: Irish Journal of Medical Science - March 18, 2016 Category: Journals (General) Source Type: research

William Wilde: his contribution to otology
Abstract Sir William Wilde pioneered the epidemiology of deafness. He set otology on a firm scientific basis by applying the principles established by Robert Graves and William Stokes of the Dublin School of Medicine of correlating clinical observation with post-mortem findings and utilising this information as a framework for therapeutic intervention. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 18, 2016 Category: Journals (General) Source Type: research

Review of cardiometabolic risk factors in a cohort of paediatric type 1 diabetes mellitus patients
Conclusions Cardiometabolic risk factors are present in this population with T1DM. Identifying cardiometabolic risk factors in adolescent T1DM patients is the first step in prevention of future morbidity and mortality. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 17, 2016 Category: Journals (General) Source Type: research

Lifestyle risk factors for cardiovascular disease and diabetic risk in a sedentary occupational group: the Galway taxi driver study
Conclusion Lifestyle risk factors for CVD and dysglycaemia are prevalent amongst Irish taxi drivers. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 16, 2016 Category: Journals (General) Source Type: research

The Assisted Decision-Making (Capacity) Act 2015: what it is and why it matters
Conclusions The 2015 Act is considerably more workable than the 2013 Bill that preceded it. Key challenges include the subtle decision-making required by patients, healthcare staff, Circuit Court judges and the director of the Decision Support Service; implementation of “advance healthcare directives”, especially if they do not form part of a broader model of advance care planning (incorporating the flexibility required for unpredictable future circumstances); and the over-arching issue of logistics, as very many healthcare decisions are currently made in situations where the patient’s capacity ...
Source: Irish Journal of Medical Science - March 15, 2016 Category: Journals (General) Source Type: research

Odontogenic myxoma of the maxilla: surgical management and case report
Conclusion We discuss various treatment approaches for management of this tumour. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 14, 2016 Category: Journals (General) Source Type: research

Use of a web-based dietary assessment tool in early pregnancy
Abstract Background Maternal diet is critical to fetal development and lifelong health outcomes. In this context, dietary quality indices in pregnancy should be explicitly underpinned by data correlating food intake patterns with nutrient intakes known to be important for gestation. Aims Our aim was to assess the correlation between dietary quality scores derived from a novel online dietary assessment tool (DAT) and nutrient intake data derived from the previously validated Willett Food Frequency Questionnaire (WFFQ). Method...
Source: Irish Journal of Medical Science - March 11, 2016 Category: Journals (General) Source Type: research

Sir William Wilde: an enlightened editor
Abstract This paper examines Sir William Wilde’s peculiar genius as editor, his contribution to the Irish Journal of Medical Science in ensuring its endurance and making it a treasure-house of the history of medicine in Ireland. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 11, 2016 Category: Journals (General) Source Type: research

William Wilde: Historian
Abstract This essay attempts to assess William Wilde as a social historian. It examines some of his contributions to the discipline of history and looks particularly at ‘The food of the Irish’, which was published in the Dublin University Magazine in February 1854. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 11, 2016 Category: Journals (General) Source Type: research

Screening for asymptomatic urogenital Chlamydia trachomatis infection at a large Dublin maternity hospital: results of a pilot study
The objective of this study was to determine the prevalence of asymptomatic urogenital C. trachomatis infection in young women attending for care at a large maternity hospital. Methods All patients aged 25 years and under attending the Hospital between December 2011 and December 2013 were offered screening for urogenital C. trachomatis infection. Nucleic acid amplification testing of the C. trachomatis cryptic plasmid was performed on either endocervical swabs or first void urine samples. Results There were 2687 women tested for C. trachom...
Source: Irish Journal of Medical Science - March 11, 2016 Category: Journals (General) Source Type: research

Concomitant cervical fractures without neurological symptoms: a case report
Conclusion Following concurrent ACDF at C6/7 and peg screw fixation of C2 through the same incision the patient made a full recovery. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 11, 2016 Category: Journals (General) Source Type: research

The lady with the dragon tattoo
Conclusion Sarcoidal tattoo reactions in those without systemic sarcoidosis are a rare occurrence, and their presence should prompt a search for systemic involvement. The accurate identification of skin involvement in sarcoidosis is important, as it tends to occur early in the course of disease, and the skin is a readily accessible site for biopsy, allowing for prompt diagnosis. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 9, 2016 Category: Journals (General) Source Type: research

Post-transplant lymphoproliferative disorder in paediatric patients: the Irish perspective—a single centre experience
Conclusion The outcome of paediatric patients treated for PTLD at our institution is at least comparable to published international series and supports the use of rituximab ± low dose chemotherapy in the treatment of this malignancy. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 29, 2016 Category: Journals (General) Source Type: research

William Wilde and 1 Merrion Square
Abstract William Wilde spent the final third of his life, from 1855 to 1876, in 1 Merrion Square. During the first half of his occupancy of the house his career blossomed to its fullest; the second decade, on the other hand, was marked by scandal, personal tragedy, and an unhappy professional and social decline. This paper considers the background to the development of Merrion Square, the architectural history of 1 Merrion Square from its building in 1762 to the arrival of the Wildes in 1855, the attractions and possibilities which the house offered for William Wilde, the major architectural expansion of the build...
Source: Irish Journal of Medical Science - February 29, 2016 Category: Journals (General) Source Type: research

An analysis of inpatient dermatologic consultations at University Hospital Limerick: inadequate infrastructure leads to acute skin failure
Conclusion Timely diagnosis and inpatient care has important implications on appropriate treatment, duration of hospital stay and patient outcome. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 26, 2016 Category: Journals (General) Source Type: research

Recurrent variceal haemorrhage managed with splenic vein stenting
Conclusion There are little data to date on splenic vein stenting in the setting of EPH secondary to non-malignant pancreatic disease. We report a case managed successfully with splenic vein stenting and review the existing literature. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 25, 2016 Category: Journals (General) Source Type: research

Attitudes towards sun exposure in inflammatory bowel disease patients taking azathioprine
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 23, 2016 Category: Journals (General) Source Type: research

Effect of flip-flops on lower limb kinematics during walking: a cross-sectional study using three-dimensional gait analysis
Abstract Background Flip-flops are a popular footwear choice in warm weather however their minimalist design offers little support to the foot. Aim To investigate the effect of flip-flops on lower limb gait kinematics in healthy adults, to measure adherence between the flip-flop and foot, and to assess the effect on toe clearance in swing. Methods Fifteen healthy adults (8 male, mean age 27 years) completed a three-dimensional gait analysis assessment using Codamotion. Kinematic and lower limb temporal-spatial...
Source: Irish Journal of Medical Science - February 22, 2016 Category: Journals (General) Source Type: research

The impact of expectant management, systemic methotrexate and surgery on subsequent pregnancy outcomes in tubal ectopic pregnancy
Conclusions Treatment of ectopic pregnancy with either expectant management or systemic MTX is equally effective as compared to surgery. Spontaneous intrauterine pregnancy rates were comparable in expectant management, systemic methotrexate and surgery. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 19, 2016 Category: Journals (General) Source Type: research

Cardiac arrest secondary to acute coronary syndrome: a 4-year observational study of patient characteristics and outcomes
Conclusions A significant proportion of patients admitted to the intensive care unit with a diagnosis of cardiac arrest secondary to acute coronary syndrome survive to hospital discharge with meaningful recovery in neurological and cardiac function. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 19, 2016 Category: Journals (General) Source Type: research

Advances in the management of severe aortic stenosis
Conclusion Multiple advances in the surgical management of aortic stenosis have occured in the past decade. An evolving spectrum of surgical and transcatheter interventions is now available depending on patient age and operative risk. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 17, 2016 Category: Journals (General) Source Type: research

A retrospective review of the type of anaesthesia used for LLETZ: proposal for a categorisation audit tool
Conclusions The use of GA for LLETZ rarely confers benefits in terms of diagnostic or therapeutic quality indicators. The categorisation we propose is a simple audit tool that could be adopted by all colposcopy units to reduce the rate of GA. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 17, 2016 Category: Journals (General) Source Type: research

24th Sylvester O’Halloran Perioperative Scientific Symposium
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 12, 2016 Category: Journals (General) Source Type: research

Regulation and registration as drivers of continuous professional competence for Irish pre-hospital practitioners: a discussion paper
Conclusion We suggest that evolving professionalisation of Irish paramedics should be affirmed through behaviours and competencies that incorporate adherence to professional codes of conduct, reflective practice, and commitment to continuing professional development. While the need for ambulance practitioner CPD was identified in Ireland almost a decade ago, PHECC now has the opportunity to introduce a model of CPD for paramedics linking competence and professionalism to annual registration. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 12, 2016 Category: Journals (General) Source Type: research

Older patient hospital admissions following primary care referral: the truth is in the referring
Conclusions Almost all primary care referrals included the required details as per recent HIQA guidelines. The further inclusion of optional information relating to patient social or functional status, which are of particular relevance to the older population may help patient management. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 9, 2016 Category: Journals (General) Source Type: research

A novel missense mutation in ATRX uncovered in a Yemeni family leads to alpha-thalassemia/mental retardation syndrome without alpha-thalassemia
Conclusions The mutated gene is predicted to have a disrupted SNF-2 domain at a conserved residue; p.Leu1889Trp, which is deemed functionally damaging. This report offers, for the first time, full clinical and molecular characterization of a novel ATRX variant in an Arab family. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 9, 2016 Category: Journals (General) Source Type: research

Metformin versus insulin in gestational diabetes mellitus: a meta-analysis of randomized clinical trials
Abstract Background Metformin is widely used in treatment of type 2 diabetes. However, whether it is safe for use in pregnancy is controversial. Methods A search for relevant studies were performed using PubMed (1948–2014), Embase (1974–2014), the Web of knowledge (1950–2014), and the Cochrane database, included all randomized control trials published in English. Results Eight RCTs (1712 patients with gestational diabetes mellitus) were retrieved; of those 853 patients were given metformin, and 85...
Source: Irish Journal of Medical Science - February 9, 2016 Category: Journals (General) Source Type: research

An exploration of the prevalence and patterns of care for women presenting with mid-trimester loss
Conclusions Results suggest the incidence of mid-trimester loss may be slightly lower than the 1 or 2 % of pregnancies reported in the literature. The incidence of mid-trimester loss in multiparous women is approximately twice that of nulliparous women. The referral services offered in the study were utilised by most of the women, as were follow-up clinic appointments. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 9, 2016 Category: Journals (General) Source Type: research

Psychopathic teamwork: lessons learned from recent terrorist attacks
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 5, 2016 Category: Journals (General) Source Type: research

The temporal fluctuations and characteristics of psychiatric inpatient admissions in Ireland: data from the HRB’s National Psychiatric In-Patient Reporting System
Abstract This paper examines trends in psychiatric inpatient admissions from the 1960s to 2014 and uses data from the National Psychiatric Inpatient Reporting System (NPIRS) to review these trends. In the 1960s the Department of Health began an annual system of reporting on the activities in Irish psychiatric units and hospitals on foot of the recommendations of the Commission of Inquiry on Mental Illness. The National Psychiatric Inpatient Reporting System (NPIRS) was established shortly thereafter and this paper discusses the data from this database contained in these annual activity reports over the last 50 yea...
Source: Irish Journal of Medical Science - February 1, 2016 Category: Journals (General) Source Type: research

Radiofrequency ablation: an assessment of clinical and cost efficacy
Abstract Background Varicose veins are common and frequently cause patient distress. In recent years, Radiofrequency ablation (RFA) has emerged as a minimally invasive alternative to traditional open venous ligation surgery. Aims The aim of this study was to directly compare RFA and open saphenofemoral ligation. Methods This was a single-centre retrospective cohort study. Consecutive patients undergoing surgical management over a 2-year period commencing from January 2011 were studied. Radiological succe...
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research

The living with asthma study: issues affecting the perceived health and well-being of Irish adults with asthma
Abstract Introduction Ireland has the fourth highest incidence of asthma in the world, with an estimated 14.7 % of the population having asthma, making it the most common chronic disease in childhood and the most common respiratory illness in Ireland. Method The aim of this qualitative enquiry, involving participant focus groups, was to investigate the health and well-being of Irish adults who have asthma, with particular interest in the influences on their health and well-being. The study population was recruited from the Asthma Society of I...
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research

MicroRNA-21 regulates the sensitivity to cisplatin in a human osteosarcoma cell line
Conclusion The miR-21 in osteosarcoma cells is a significant modulator of the anti-tumor effect of CDDP by regulating the expression of bcl-2, and the study reveals a novel mechanism of osteosarcoma drug resistance. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research

Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?
Conclusions Curcumin can prevent and ameliorate NASH via lipid reduction, improve insulin resistance, improve anti-inflammatory, and have antioxidant effects, possibly related to its activation of Nrf2. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research

The evaluation of brain natriuretic peptide changes and difficult airway predictors during perioperative period of pregnancy
Abstract Aim Airway changes, difficult ventilation, and intubation are the leading causes of morbidity and mortality in pregnancy, but no prospective study has evaluated the relationship between airway changes and brain natriuretic peptide (BNP) before and after cesarean section operations. The purpose of this study was to evaluate the relationship between BNP and airway changes in women undergoing delivery and during the postoperative period. Materials and methods Included in this prospective study were a total of 35 pregnant females with ASA I p...
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research

Unexplained developmental delay/learning disability: guidelines for best practice protocol for first line assessment and genetic/metabolic/radiological investigations
Conclusion It is hoped that these recommendations will become national guidelines for the first line metabolic, genetic and radiological investigation of patients presenting with unexplained GDD/ID. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research

The improved accuracy of planar bone scintigraphy by adding single photon emission computed tomography (SPECT-CT) to detect skeletal metastases from prostate cancer
Conclusion SPECT-CT improves the diagnostic accuracy of PBS in detecting skeletal metastasis from PC and is superior to PBS alone in differentiating benign from malignant lesions. Notwithstanding resource implications of increased cost, specialist equipment and specialist manpower hours; we recommend the use of SPECT-CT in conjunction with PBS for targeted evaluation of suspicious bony lesions in this cohort of patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research

Total rhinectomy, a clinical review of nine cases
Conclusion Total rhinectomy is an uncommon procedure usually undertaken for extensive nasal malignancy. Nasal prosthetic rehabilitation is a viable method of reconstruction. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - December 24, 2015 Category: Journals (General) Source Type: research

High risk HPV testing following treatment for cervical intraepithelial neoplasia
Conclusion HR HPV is more sensitive than cytology for detection of persistent CIN. However, 19 women with positive HR HPV had normal colposcopy with no persistent CIN detected. A national cost-benefit analysis is recommended to determine the value of the second co-test. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - December 21, 2015 Category: Journals (General) Source Type: research

Post-chemotherapy retroperitoneal lymph node dissection in the management of metastatic testis cancer: the 16-year experience in an Irish setting
Conclusion In this relatively small series due to small population and low disease incidence, we have shown acceptable peri-operative course, morbidity and oncological outcomes with PC-RPLND compared to major international centres. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - December 21, 2015 Category: Journals (General) Source Type: research

Erratum to: Role of central and peripheral opioid receptors in the cardioprotection of intravenous morphine preconditioning
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - December 18, 2015 Category: Journals (General) Source Type: research

Horizontal nystagmus and multiple sclerosis using 3-Tesla magnetic resonance imaging
Conclusion In MS patients with horizontal nystagmus, lesions in all cortical eye fields and their descending connections were evident. Technical improvements in tractography may help identify the specific site(s) resulting in nystagmus in MS. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - December 17, 2015 Category: Journals (General) Source Type: research

The institutional response to mental disorder in Ireland: censuses of Irish asylums, psychiatric hospitals and units 1844–2014
Abstract Before the eighteenth century, there was limited response to the problem of psychiatric illness in Ireland as in many other countries. The asylums of the 1820s and 1830s were no sooner opened than they were overcrowded. A second wave of asylum building commenced in the second half of the nineteenth century continuing up to the early twentieth century. In 1966, the Report of the Commission on Mental Illness noted that the rate of psychiatric beds in Ireland per 1,000 was one of the highest in the world. The report called for a change in the policy of caring for the mentally ill in psychiatric hospitals to...
Source: Irish Journal of Medical Science - December 14, 2015 Category: Journals (General) Source Type: research

Risky sun tanning behaviours amongst Irish University students: a quantitative analysis
Abstract Background Despite Ireland’s temperate maritime climate, it has the third highest rate of malignant melanoma in the European Union, indicating the need to recognise tanning practices as a risky behaviour, especially amongst those most at risk (the younger population). Aim To explore the factors associated with deliberate sun tanning amongst university students in Cork, Ireland. Methods Self-reported sun exposure, attitudes to tanning and sun protection practices were investigated using an online ques...
Source: Irish Journal of Medical Science - December 12, 2015 Category: Journals (General) Source Type: research

Therapeutic goals in patients with pheochromocytoma: a guide to perioperative management
Conclusion A multidisciplinary team approach is best throughout the perioperative period to prevent potential complications that arise. The hospital physician, intensivist, anesthetist and cardiovascular specialist play a pivotal role in the management of patients with pheochromocytoma. In addition to the pharmacologic and volume recommendations, a multidisciplinary discussion allows for seamless implementation of an organized plan of care. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - December 9, 2015 Category: Journals (General) Source Type: research

Push and stay factors affecting Irish medical student migration intentions
Conclusion This study has provided insight into the factors that influence medical student migration intentions. There is a strong need for all stakeholders to collectively discuss and engage in possible solutions. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - December 9, 2015 Category: Journals (General) Source Type: research

Oncological and functional outcomes of transoral surgery for the treatment of oropharyngeal cancer
Conclusion Transoral resection is an excellent option for selected patients with OPSCC, offering excellent functional and oncological outcomes. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - November 18, 2015 Category: Journals (General) Source Type: research

Influence of age and gender on Doppler index of diastolic function in Chinese hypertensive patients
Abstract Aim This paper explores age- and gender-specific changes in Doppler echocardiographic index-E′ of left ventricular diastolic function. Methods The study involved 366 hypertensive patients (197 men and 169 women) who were aged from 20 to 90 years (mean 58.60 ± 15.68 years), without a diagnosis of any other disease. Early diastolic mitral inflow velocity (E), late diastolic mitral annular velocity (A), and E/A ratio were measured with pulse wave Doppler. Early diastolic mitral annular velocity (E′) and...
Source: Irish Journal of Medical Science - October 20, 2015 Category: Journals (General) Source Type: research

Validation of a nomogram predicting sentinel lymph node status in melanoma in an Irish population
Abstract Background Sentinel lymph node (SLN) positivity is an important prognostic factor in cutaneous melanoma. A nomogram has been developed at Memorial Sloan-Kettering Cancer Centre (MSKCC) to predict SLN positivity and this may be useful to select patients for SLN biopsy. Aims We aimed to determine whether this nomogram would be of clinical use in an Irish population. Methods Age, Breslow thickness, Clark’s level, presence of ulceration and tumour location indices were used to calculate the pr...
Source: Irish Journal of Medical Science - October 20, 2015 Category: Journals (General) Source Type: research