Erratum to: 24th Sylvester O ’Halloran Perioperative Scientific Symposium
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - August 17, 2016 Category: Journals (General) Source Type: research

XL1st Sir Peter Freyer Memorial Lecture and Surgical Symposium Arts Millennium Building, National University of Ireland Galway, 2nd & amp; 3rd September 2016
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - August 11, 2016 Category: Journals (General) Source Type: research

Reply to the article: Gleeson M et al. (2013) An audit of generic prescribing in a general surgical department. Ir J Med Sci 182:403 –408
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - August 10, 2016 Category: Journals (General) Source Type: research

The impact of outpatient systemic anti-cancer treatment on patient costs and work practices
ConclusionThis study highlights the need for greater awareness of indirect expenditures associated with systemic anti-cancer therapy in Ireland. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - August 6, 2016 Category: Journals (General) Source Type: research

Ireland ’s contribution to urology and nephrology research in the new millennium: a bibliometric analysis
ConclusionWe believe this study to be the largest bibliometric analysis in the field of urology and nephrology internationally. This study provides a novel overview of the current Irish urology- and nephrology-related research, and examines how our results compare within the international community. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - August 2, 2016 Category: Journals (General) Source Type: research

Comparison of GlideScope video laryngoscopy and Macintosh laryngoscope in ear –nose and throat surgery
Conclusion In our study, despite the longer intubation times in group G, the haemodynamic response was significantly lower in this group. It is believed that especially in cases with vital requirement of haemodynamic stability, the GlideScope video laryngoscope would be safer to employ. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 22, 2016 Category: Journals (General) Source Type: research

Evaluation of local anaesthetic infiltration for cryosurgery of hand warts: a prospective comparative study
Abstract Background The pain of cryosurgery for hand warts can lead to poor patient satisfaction and inadequate response to treatment. Aim To determine if local anaesthetic infiltration using a 30-gauge needle prior to cryosurgery is acceptable to patients. Method 20 consecutive patients were recruited over a 14-month period who attended a cryosurgery clinic and who had at least two warts between 5 and 10 mm in diameter on different parts of the hands. In each patient, two warts of approximately equ...
Source: Irish Journal of Medical Science - July 14, 2016 Category: Journals (General) Source Type: research

Comparison of GlideScope video laryngoscopy and Macintosh laryngoscope in ear–nose and throat surgery
Conclusion In our study, despite the longer intubation times in group G, the haemodynamic response was significantly lower in this group. It is believed that especially in cases with vital requirement of haemodynamic stability, the GlideScope video laryngoscope would be safer to employ. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 14, 2016 Category: Journals (General) Source Type: research

Effect of integrating HIV and addiction care for non-engaging HIV-infected opiate-dependent patients
Conclusion Integration of HIV and addiction care optimises the physical health of non-engaging HIV-positive opiate-dependent patients with no substantial effect on their methadone maintenance programme. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 14, 2016 Category: Journals (General) Source Type: research

Depression and alcohol withdrawal syndrome: is antidepressant therapy associated with lower rates of hospital readmission?
Abstract Background Alcohol withdrawal syndrome (AWS) is a frequent cause of admission to acute care hospitals and many of these patients have a history of depression. Aim Our objective was to determine if antidepressant use in patients with a history of depression is associated with lower rates of hospital readmission for AWS. Methods A retrospective study was performed of patients admitted with AWS between January 1, 2006 and December 31, 2008 to an academic tertiary referral hospital. ...
Source: Irish Journal of Medical Science - July 14, 2016 Category: Journals (General) Source Type: research

Comparison of polyethylene glycol vs sodium picosulphate vs sodium biphosphonate by efficacy in bowel cleansing and patients’ tolerability: a randomised trial
Conclusion For adequate bowel cleansing PEG-EOS is the most effective but is the least tolerated and least preferred among patients. Addition of flavour increases significantly patients’ acceptance of PEG-EOS. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 14, 2016 Category: Journals (General) Source Type: research

Obturator nerve block transurethral surgery for bladder cancer: comparison of inguinal and intravesical approaches: prospective randomized trial
Conclusion Obturator nerve block plays an additive role on the quality of analgesia for bladder surgery. Our data suggests that identification of the obturator nerve with ultrasound is easy and the block can be assessed by observing avoidance of bladder spasm. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 14, 2016 Category: Journals (General) Source Type: research

Postpartum dyslipidaemia in women diagnosed with gestational diabetes mellitus
The objective of this study was to determine the prevalence of dyslipidaemia postpartum in women with GDM. Methods The study was performed in a large university hospital. Women with GDM had a fasting lipid profile performed 6 weeks postnatally. Clinical details were obtained from the medical records. Lipid results in our cohort were compared with healthy women of the same age. Results The overall prevalence of postpartum dyslipidaemia was 52 % (n = 51). Total cholesterol was raised in 44 % (n = 43), low-densit...
Source: Irish Journal of Medical Science - July 11, 2016 Category: Journals (General) Source Type: research

The impact of contemporary multidisciplinary meetings on workload at a tertiary level hospital
Conclusion The complexity and range of cases at MDMs continue to expand, serving local and national needs, though service plans do not acknowledge their role in the working day. Our study shows just one element that clearly signals a need to take account of the new methods of delivering modern healthcare. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 11, 2016 Category: Journals (General) Source Type: research

Influence of a CYP1A2 polymorphism on post-exercise heart rate variability in response to caffeine intake: a double-blind, placebo-controlled trial
Conclusions Rate of RMSSD recovery was the only variable influenced by the CYP1A2*IF polymorphism during post-exercise in response to caffeine intake. Thus, the CYP1A2*1F polymorphism did not overtly influence the effects of caffeine intake on post-exercise HRV. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 1, 2016 Category: Journals (General) Source Type: research

Does the working temperature affect the outcome following microwave endometrial ablation?
Conclusion MEA is more effective in treating menorrhagia when used at a higher operating temperature. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - June 30, 2016 Category: Journals (General) Source Type: research

Inhibitory effects of bevacizumab monoclonal antibodies in combination with chemotherapy in different time sequences on a human gastric carcinoma cell line
This study investigated the inhibitory effects of bevacizumab monoclonal antibodies in combination with chemotherapy in different time sequences on a human gastric cancer cell line (MGC-803). Methods Cultured MGC-803 human gastric cancer cells were treated with bevacizumab in combination with chemotherapy treatment in different time sequences. The effects on cell growth inhibition were determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell cycle distribution and the rate of cell apoptosis were determined by propidium iodide staining followed by ...
Source: Irish Journal of Medical Science - June 28, 2016 Category: Journals (General) Source Type: research

Appropriate pathology ordering? Troponin testing within an Australian Emergency Department
Conclusion Troponin testing is important in the diagnosis of myocardial infarction, although should not be ordered routinely, or unnecessary. This study has determined that using clinical guidelines can promote rational ordering, and that testing should ultimately benefit patient management. Reducing inappropriate pathology test ordering is important to maximize productive clinical time, reduce false positives, maximize patient care, and to reduce financial waste. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - June 24, 2016 Category: Journals (General) Source Type: research

Late effects of chemotherapeutic agents on renal function in childhood cancer survivors: a review of the literature
Conclusion As more childhood cancer survivors are reaching adulthood, a new niche of cancer research has emerged. Researchers are now investigating the late effects due to cytotoxic treatments. Renal function impairment is a potential late effect of treatment with nephrotoxic chemotherapeutic agents including ifosfamide, cisplatin, carboplatin and methotrexate. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - June 23, 2016 Category: Journals (General) Source Type: research

Fumaric acid esters for psoriasis: a systematic review
Conclusion In conclusion, the use of FAE in the management of moderate to severe psoriasis is a promising treatment option, especially for those patients intolerant of, or unresponsive to other agents. If blood parameters are closely monitored during treatment as per the European Medicine Agencies guidelines (European Medicines Agency, ‘Updated recommendations to minimise the risk of the rare brain infection PML with Tecfidera’, http://www.ema.europa.eu/docs/en_GB/document_library/Press_release/2015/10/WC500196017.pdf, 2015) they may be safely used in practice. The licensing of FAEs in Ireland for the...
Source: Irish Journal of Medical Science - June 7, 2016 Category: Journals (General) Source Type: research

The use of ultrasonography and digital mammography in women under 40 years with symptomatic breast cancer: a 7-year Irish experience
Abstract Background Breast cancer in women under 40 years of age is rare and typically presents symptomatically. The optimal imaging modality for this patient group is controversial. Most women undergo ultrasonography with/without mammography. Young women typically have dense breasts, which can obscure the features of malignancy on film mammography, however, initial studies have suggested that digital mammography may have a more accurate diagnostic performance in younger women. Ultrasound generally performs well in this age group, although it is poor at detecting carcinoma in situ (DCIS)....
Source: Irish Journal of Medical Science - June 7, 2016 Category: Journals (General) Source Type: research

Proceedings of the RAMI Intern Section Meeting, 30 January 2016, Royal College of Physicians of Ireland
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - June 3, 2016 Category: Journals (General) Source Type: research

Combination of infliximab with thiopurines significantly reduces white cell and neutrophil counts in inflammatory bowel disease patients
Abstract Background The effects of thiopurines on white cell count are well documented. Objective We compared the effects of infliximab 5 mg/kg monotherapy and combination of infliximab with thiopurines on the total and differential white cell count (WBC). Methods 13 IBD patients treated with infliximab monotherapy and 18 IBD patients treated with a combination of infliximab and thiopurines were included in the study. Using retrospective data, cell counts were examined prior to induction of infliximab, and at ...
Source: Irish Journal of Medical Science - May 30, 2016 Category: Journals (General) Source Type: research

Child mortality and the Sustainable Development Goals: a challenge and an opportunity
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 21, 2016 Category: Journals (General) Source Type: research

“Suicide shall cease to be a crime”: suicide and undetermined death trends 1970–2000 before and after the decriminalization of suicide in Ireland 1993
This study investigates 10,353 suicide deaths in Ireland that took place between 1970 and 2000. Irish 1970–2000 annual suicide data were obtained from the Central Statistics Office and modelled via a negative binomial regression approach. We examined the effect of suicide legislation on different age groups and on both sexes. We used Bonferroni correction for multiple modelling. Statistical analysis was performed using the R statistical package version 3.1.2. The coefficient for the effect of suicide act on overall suicide deaths was −9.094 (95 % confidence interval (CI) −34.086 to 15.899), statistic...
Source: Irish Journal of Medical Science - May 17, 2016 Category: Journals (General) Source Type: research

Audit of compliance with the British Committee for Standards in Haematology (BCSH) revised guidelines for the diagnosis and assessment of treatment response of hairy cell leukemia in University Hospital Galway
Conclusion This audit highlights areas of improvement in the diagnosis and management of HCL in UCHG, which do not currently adhere to the BCSH recommendations. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 11, 2016 Category: Journals (General) Source Type: research

"5th Annual Meeting Frontiers in Neurology 2015"
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 9, 2016 Category: Journals (General) Source Type: research

Is it time to introduce varicella vaccine to our children?
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 9, 2016 Category: Journals (General) Source Type: research

From inflammation to cancer
Conclusion In this article we present a brief history of the discovery mechanisms and potential links between acute and chronic inflammation and cancer. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 7, 2016 Category: Journals (General) Source Type: research

A history of haematology: from Herodotus to HIV, Shaun R. McCann
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 6, 2016 Category: Journals (General) Source Type: research

Targeted temperature management in cardiovascular disease complicated by cardiac arrest
Conclusions The study demonstrates a possible beneficial effect of TTM on long-term cardiac function, when instituted following cardiac arrest. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 4, 2016 Category: Journals (General) Source Type: research

Procalcitonin and C-reactive protein in early diagnosis of sepsis caused by either Gram-negative or Gram-positive bacteria
Abstract Background Sepsis is the most frequent cause of systemic inflammatory response syndrome (SIRS). Procalcitonin (PCT) and C-reactive protein (CRP) are well-known predictors of sepsis. Serum PCT levels are associated with blood culture positivity in patients with sepsis, but the magnitude of elevation of PCT and CRP levels at the onset of sepsis is unknown in Gram-negative (GN) bacteremia and in Gram-positive (GP) bacteremia. Aims To evaluate the PCT and CRP levels in 72 h at the onset of sepsis in GN and GP bacteremia. ...
Source: Irish Journal of Medical Science - May 2, 2016 Category: Journals (General) Source Type: research

The involvement of central beta-endorphin in the cardioprotective effects of remote preconditioning mediated by the intracerebroventricular administration of morphine
Conclusion Central but not peripheral β-EP is involved in morphine remote preconditioning and plays a role in the ongoing mediation of cardioprotective effects. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 22, 2016 Category: Journals (General) Source Type: research

Preoperative curves of greater magnitude (>70°) in adolescent idiopathic scoliosis are associated with increased surgical complexity, higher cost of surgical treatment and a delayed return to function
This study aimed to examine the impact of preoperative curves>70° vs. those ≤70° on perioperative, functional and financial outcomes in patients with AIS undergoing posterior spinal fusion (PSF). Methods Seventy seven eligible AIS patients who underwent PSF were prospectively followed-up, until return to preoperative function was reported. Preoperative curves>70° vs. ≤70° were analysed in relation to surgical duration, estimated blood loss, perioperative complications, length of hospitalisation, return to function and cost of surgical treatment per pat...
Source: Irish Journal of Medical Science - April 22, 2016 Category: Journals (General) Source Type: research

Paediatric learning in a clinical attachment: undergraduate medical students’ perspectives
Conclusions A clinical learning environment that allows medical students to become actively involved in patient care and to contribute as members to the clinical team can enhance their learning experience. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 22, 2016 Category: Journals (General) Source Type: research

Demographic and clinical factors predicting retention in methadone maintenance: results from an Irish cohort
Conclusion Patients who were older, single, living in their own home, on a higher dose of methadone, or taking antipsychotic medications had fewer breaks in treatment. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 22, 2016 Category: Journals (General) Source Type: research

Evaluation of patients diagnosed with essential arterial hypertension through network analysis
Abstract Background Essential hypertension is a chronic pathology that causes long-term complications due to late diagnosis of patients, the inability to control the disease through medication, or due to the complexity of associated risk factors. Aims Our study sets out to identify specific patterns of response to arterial hypertension treatment, by taking into consideration the multiple connections between risk factors in a relevant population of hypertensive patients. Methods Network science is an emer...
Source: Irish Journal of Medical Science - April 22, 2016 Category: Journals (General) Source Type: research

Prevalence of and risk factors for osteoporosis in adults with acquired brain injury
Abstract Background Low bone mineral density (BMD) is common in older people with stroke, particularly in the paretic limb. Younger people with acquired brain injury (ABI), of all causes, are at increased risk of low BMD. Aims To examine prevalence of low BMD, based on World Health Organisation diagnostic criteria, in patients with ABI. Methods This is a cross-sectional study of 112 ABI patients. All completed a questionnaire, had laboratory investigations and DXA assessment of lumbar spine and one or bo...
Source: Irish Journal of Medical Science - April 22, 2016 Category: Journals (General) Source Type: research

Concussion in rugby: knowledge and attitudes of players
Abstract Background Concussion is a traumatic brain injury, resulting in the alteration of mental status with or without loss of consciousness. There is increasing awareness that recurrent concussion may contribute to long-term neurological complication. Aims To determine player knowledge and attitudes regarding concussion. To identify sources of information and medical care, and to estimate the incidence of concussion in this group. To determine if player gender and grade of competition are associated with differences in knowledge, attitudes, med...
Source: Irish Journal of Medical Science - April 22, 2016 Category: Journals (General) Source Type: research

Cost-effectiveness of exercise stress testing performed as part of executive health examinations
Conclusion Based on the results of this study, exercise stress tests should not be routinely offered as part of executive health examinations. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 20, 2016 Category: Journals (General) Source Type: research

An observational study of the utility of continuous positive airway pressure ventilation for appropriate candidates in prehospital care in the Midwest region
Conclusions This study suggests that a suitable patient cohort for CPAP exists in the prehospital environment and highlights the need for a prospective study of CPAP use on these patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 18, 2016 Category: Journals (General) Source Type: research

Relationship between leptin concentration and body fat with peripheral blood mononuclear cells cytokines among obese and overweight adults
Abstract Background Overweight and obesity has been suggested to be well correlated with altered levels of pro-inflammatory cytokines. Aim The purpose of this study is to assess the relationship of body fat mass (BFM), body fat percentage (BFP) and leptin levels with peripheral blood mononuclear cells (PBMCs) cytokines among obese and overweight adults. Methods Eighty-two overweight and obese individuals were divided into two BMI-category groups (BMI
Source: Irish Journal of Medical Science - April 16, 2016 Category: Journals (General) Source Type: research

Aggressive medullary thyroid cancer, an analysis of the Irish National Cancer Registry
Conclusions Our patient cohort was substantially older and presented at an advanced T status than what is commonly seen in the literature. This may account for poor survival outcomes and the very low pick-up of RET mutations in sporadic medullary thyroid cancer. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 15, 2016 Category: Journals (General) Source Type: research

Dedicated orthogeriatric service reduces hip fracture mortality
Abstract Background Hip fracture is a common serious injury afflicting the geriatric population and is associated with poor clinical outcomes, functional and walking disabilities and high 1-year mortality rates. A multidisciplinary approach has been shown to improve outcomes of geriatric patients with fragility fracture. Aims We piloted a dedicated orthogeriatric service for hip fracture patients to determine if the service facilitated a change in major patient outcomes, such as mortality, length of stay and dependency. Meth...
Source: Irish Journal of Medical Science - April 8, 2016 Category: Journals (General) Source Type: research

EWTD compliance amongst Anaesthesia trainees in Ireland
Conclusion As work patterns change, it is vital to ensure that training is not compromised. Previous reports have recommended an increase in consultant numbers, which has yet to be achieved. This may provide a solution to allow service provision, NCHD training and EWTD compliance amongst NCHDs. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 8, 2016 Category: Journals (General) Source Type: research

Evaluating the cost of iatrogenic urethral catheterisation injuries
Conclusion Iatrogenic injuries during UC represent a significant cost burden to the healthcare system. Training programmes should be compulsory for all healthcare professionals routinely involved in catheterisation procedures. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 6, 2016 Category: Journals (General) Source Type: research

Routine ureteric stenting before cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy in managing peritoneal carcinomatosis from gynecologic malignancies: a single-center experience
Conclusions Prophylactic ureteric stents appeared to be feasible, potentially safe, and could reduce the risk of iatrogenic ureteric injuries without incurring an increase in urinary tract-related complications. Prophylactic ureteric stenting does not eliminate the necessity for competent anatomical knowledge, meticulous retroperitoneal dissection and direct intra-operative visualization of ureters. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 6, 2016 Category: Journals (General) Source Type: research

The potential diagnostic value of vitreous humor analyses at autopsy is not appreciated
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 1, 2016 Category: Journals (General) Source Type: research

Fifty Sixth Annual Meeting of the Irish Otorhinolaryngology/Head and Neck Society
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 1, 2016 Category: Journals (General) Source Type: research

Radon testing in rapid access lung clinics: an opportunity for secondary prevention
Conclusions The development of RALC’s offers a novel opportunity to integrate the concepts of radon exposure, cigarette smoking and the development of lung cancer, and to reinforce this message in the minds of at risk patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 30, 2016 Category: Journals (General) Source Type: research