Iranian Journal of Pharmaceutical Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Complexity of Response to the Proliferation Agonist and Antagonist Agents, in the Breast Cancer Cell Lines with Various Receptors
 AbstractBreast cancer is a heterogeneous disease in which many factors and receptors are effective in the disease process and response to treatment. Currently, estrogen, progesterone, and HER2 receptors are among the most important factors in choosing a treatment regimen. Other metabolic factors that may affect the treatment outcome include diabetes and hyperinsulinemia. In order to evaluate the role and complexity of cross-talk between different pathways initiating from various receptors, value the most common drugs in the treatment of breast cancer are investigated on different cell lines in this manuscript at ...
Source: Iranian Journal of Pharmaceutical Research - February 16, 2022 Category: Drugs & Pharmacology Source Type: research

Novel 2-(diphenylmethylidene)malonic Acid Derivatives as Anti- HIV Agents: Molecular Modeling, Synthesis and Biological Evaluation
In this study, a novel series of 2-(diphenyl methylidene) malonic acid derivatives were designed as triple inhibitors of HIV reverse transcriptase, integrase, and protease. Docking models revealed that the target compounds have appropriate affinities to the active sites of the three HIV key enzymes. The synthesized malonic acid analogs were evaluated for their activities against the HIV virus (NL4-3) in HeLa cells cultures. Among them, compound 3 was the most potent anti-HIV agent with 55.20% inhibition at 10μM and an EC50 of 8.4μM. Interestingly, all the synthesized compounds do not show significant cytotoxi...
Source: Iranian Journal of Pharmaceutical Research - February 14, 2022 Category: Drugs & Pharmacology Source Type: research

Developing a Multifaceted Evaluation Tool for Electronic Prescribing System: A Study from a Developing Country
This study was conducted in two main steps in 2018. In the first step, we conducted a literature review to find the main features and capabilities of the prosperous EPS. In the second step, a Delphi method was used for determining the final criteria for evaluating EPS. After preparing a primary questionnaire based on the first step results, 27 expert stakeholders from related fields participated in this 3-phase Delphi study. The narrative content analysis and descriptive statistics were used for data analysis.The final evaluation tool consists of 61 questions in 10 main dimensions, including practical capabilities of the p...
Source: Iranian Journal of Pharmaceutical Research - February 8, 2022 Category: Drugs & Pharmacology Source Type: research

Piperine Increases Pentagamavunone-1 Anti-cancer Activity on 4T1 Breast Cancer through Mitotic Catastrophe Mechanism and Senescence with Sharing Targeting on Mitotic Regulatory Proteins
This study expects to achieve higher effectiveness of PGV-1 on 4T1 breast cancer cells through co-treatment with piperine with exploring the effect of cytotoxicity, mitotic catastrophe, cellular senescence, and target proteins of PGV-1 and piperine on the regulation of mitosis in TNBC cells (4T1). The assays emphasize MTT assay, May Grünwald– Giemsa staining, SA-β-galactosidase assay, and bioinformatics analysis, respectively, to elicit the respected activities. The results revealed that PGV-1 performed a cytotoxic effect with an IC50 value of 9μM while piperine showed a lower cytotoxic e...
Source: Iranian Journal of Pharmaceutical Research - February 4, 2022 Category: Drugs & Pharmacology Source Type: research

Review on Approved and Inprogress COVID-19 Vaccines
The last generation of Coronavirus named COVID-19 is responsible for the recent worldwide outbreak. Concerning the widespread and quick predominance, there is a critical requirement for designing appropriate vaccines to surmount this grave problem. Correspondingly, in this revision, COVID-19 vaccines (which are being developed until March 29th, 2021) are classified into specific and non-specific categories. Specific vaccines comprise Genetic-based Vaccines (mRNA, DNA), Vector-based, Protein/recombinant protein vaccines, Inactivated viruses, Live-attenuated vaccines, and novel strategies including microneedle arrays (MNAs),...
Source: Iranian Journal of Pharmaceutical Research - January 29, 2022 Category: Drugs & Pharmacology Source Type: research

Cloning, Expression and Purification of Full-length Recombinant Ecarin and Comparing Its Expression and Function with Its Truncated Form
Ecarin is a metalloproteinase found in snake venom (SVMP) with an important role in coagulation and control of hemostasis. It can specifically produce active-thrombin from prethrombin-2 and does not differentiate between normal and abnormal prothrombin. It is used in diagnostic tests and to evaluate the treatment process of many diseases. There are many drawbacks associated with separating these compounds from snake venom. Therefore, in this study, full-length recombinant Ecarin (r-Ecarin) was cloned, expressed, and purified in eukaryotic host cells. To determine the most effective form of the enzyme, r-Ecarin was compared...
Source: Iranian Journal of Pharmaceutical Research - January 16, 2022 Category: Drugs & Pharmacology Source Type: research

The Effect of Propofol Anesthesia on the Pain Severity and Frequency of Migraine Attacks in Patients with Chronic Migraine Headache over a Six Month Follow Up: An Observational Study
In conclusion, since about half of the patients had significant improvement in the headache, propofol anesthesia may be considered as an acceptable anesthetic method in patients with migraine.  (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 2, 2022 Category: Drugs & Pharmacology Source Type: research

Primary Assessment of Mycosporine-Like Amino Acids Production by Two Species of Fischerella sp.
In conclusion, both Fischerella sp. studied here were capable of producing MAAs and can be evaluated for use in sunscreen pharmaceutical and cosmetic products. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 2, 2022 Category: Drugs & Pharmacology Source Type: research

The Effective Role of Adding Letrozole to Methotrexate in the Management of Tubal Ectopic Pregnancies, a Randomized Clinical Trial
This study was conducted in an academic hospital affiliated to Tehran University of Medical Sciences. Women with EP and stable vital signs withβ-hCG levels≤3500 were assigned randomly to receive MTX + placebo or MTX + letrozole. The regression pattern ofβ-hCG, need for further surgery, and potential side effects were compared between groups. A total of 90 women were assigned equally to the study groups and were matched in age, body mass index (BMI), serum biochemistry, and primary levels ofβ-hCG. No drug-related side effects were observed in groups. The rates of further surgery (p = 0.614)...
Source: Iranian Journal of Pharmaceutical Research - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Antimicrobial, Cytotoxic and Oxidative Stress Inhibitory Activities of Terpenoids and Flavonols from Senegalia nigrescens (Oliv.) P.J.H. Hurter
In conclusion, tested compounds represent potential promising candidates as antimicrobial, anticancer and antidotes for LPS-induced oxidative stress. This is the first report on the antifungal, cytotoxicity and antioxidative activities of the ent-kaurene diterpenoid, ent-kaur-15-en-18,20-diol (3). (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Tankyrase Inhibitor for Cardiac Tissue Regeneration: an In-silico Approach
Myocardial infarction causes heart tissue damages; therefore, using non-invasive methods to regenerate the heart tissue could be very helpful. Recent studies claimed that the inhibition of the Wnt signaling could promote cardiac remodeling and induce cardiac regeneration. Therefore, a tankyrase inhibitor to stabilize the AXIN and inhibit the Wnt/β-catenin signaling pathway will induce cardiac regeneration after injury. In this regard, virtual screening procedure, using molecular docking of 9127 FDA and world approved drugs, including herbal medicine, was done over the crystal structures of tankyrase 1 (TNKS1) and ...
Source: Iranian Journal of Pharmaceutical Research - January 1, 2022 Category: Drugs & Pharmacology Source Type: research

Preparation and Characterization of Lidocaine-loaded, Microemulsion-Based Topical Gels
Microemulsion-based gels (MBGs) were prepared for transdermal delivery of lidocaine and evaluated for their potential for local anesthesia. Lidocaine solubility was measured in various oils, and phase diagrams were constructed to map the concentration range of oil, surfactant, cosurfactant, and water for oil-in-water (o/w) microemulsion (ME) domains, employing the water titration method at different surfactant/cosurfactant weight ratios. Refractive index, electrical conductivity, droplet size, zeta potential, pH, viscosity, and stability of fluid o/w MEs were evaluated. CarbomerÒ 940 was incorporated into the fl...
Source: Iranian Journal of Pharmaceutical Research - December 31, 2021 Category: Drugs & Pharmacology Source Type: research

An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice
In this study, mice were exposed to a single intraperitoneal injection of 200 mg/kg TAA to induce hepatitis. Following Sch B (20 mg/kg/day, 28 consecutive days) treatment, biochemistry analysis and histopathological examination of different organs were performed, in addition to western blotting and flow cytometry to evaluate the involvement of inflammasomes and apoptotic proteins. Our results showed that administration of Sch B protected against TAA-induced damages, and it disparately affected inflammasome activation and apoptosis in different organs. Furthermore, Sch B treatment improved organ function, as indicated by th...
Source: Iranian Journal of Pharmaceutical Research - December 27, 2021 Category: Drugs & Pharmacology Source Type: research

Improvement of the Solubility Amphotericin B Using Olive Oil Nanoemulsion Coated with Chitosan for More Effective Treatment of Zoonotic Cutaneous Leishmaniasis
Amphotericin B (AMB) is a macrolide polyene antibiotic presenting potent anti-cutaneous leishmania activity. Nonetheless, its low water solubility, side effects, and toxicity have limited its therapeutic efficiency. The present study aimed to improve the solubility of AmB in oil-in-water using chitosan and determine its cytotoxicity on macrophages, as well as Leishmania major promastigote and amastigote. Olive oil, span 80, tween 80, AmB, and DMSO were employed as excipients, and nanoemulsions (NEs) were prepared by sonicator bath at 37°C for 1 h at the highest power and stirred overnight with pH 5.5. Thereafter, c...
Source: Iranian Journal of Pharmaceutical Research - December 27, 2021 Category: Drugs & Pharmacology Source Type: research