Iranian Journal of Pharmaceutical Research 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Controllable Synthesis of Polymeric Micelles by Microfluidic Platforms for Biomedical ...
Polymeric micelles (PMs) are one of Nanoscale delivery systems with high stability, loading capacity, and biocompatibility. PMs are nano-sized and spherical particles with a hydrophilic shell and hydrophobic core or reverse depending on their applications. Polymeric micelles could be synthesized by different methods, such as direct dissolution, dialysis method, and lyophilization. Microfluidics is also a relatively modern approach for this purpose, in which chemical reactions are carried out in the microchannels. Compared with conventional preparation methods, the microfluidic technique produces homogeneous polymeric micel...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Synthesis, Kinetics, Binding Conformations and Structure-activity Relationship of Potent ...
Considering the diversified pharmacological importance of thiazole and triazole heterocyclic moieties, a unique series of S-aralkylated bi-heterocyclic hybrids, 7a-l, was synthesized in a convergent manner. The structures of newly synthesized compounds were characterized by 1H-NMR, 13C-NMR, IR, and EI-MS spectral studies. The structure-activity relationship of these compounds was envisaged by analyzing their inhibitory effects against tyrosinase, whereby all these molecules exhibited potent inhibitory potentials relative to the standard used. The Kinetics mechanism was ascertained by Lineweaver-Burk plots, which revealed t...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Efficacy and Safety of Melatonin as an Adjunctive Therapy on Clinical, Biochemical, and Quality ...
Ulcerative colitis (UC) is characterized by recurring episodes of inflammation limited to the mucosal layer of the colon. The exact etiology of UC is unknown, but the role of autoimmunity and activated inflammatory cascade is quite clear. Melatonin possesses anti-inflammatory and immune-modulative properties in animal and clinical trials. The aim of the present study was to evaluate the efficacy and safety of oral melatonin as an adjudicative therapy in clinical, biochemical, and quality of life in UC patients. Thirty patients diagnosed with mild to moderate UC, were randomly allocated to either receive melatonin (3 mg/d) ...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Improvement of Drug Delivery Properties of Risperidone via Preparation of Fast Dissolution ...
Aimed to improve the dissolution profile of risperidone and increase the compliance of psychotic patients, we designed a fast dissolution tablet (FDT) containing nanoparticles. Risperidone nanoparticles were prepared by the acid-alkali neutralization method, and their size and stability were evaluated. Spray freeze-drying (SFD) process was then employed to fabricate the nanoaggregates using sugars. The physicochemical properties of the dried powders were assessed. Finally, nanoaggregates were compressed into tablets, and their properties were evaluated.The results show that the synergic effect of cremophore EL and hydroxyp...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Multilayer Alginate Microcapsules For Live Cell Microencapsulation; Is There Any Preference For ...
Since 1980 after introducing the concept of live cell encapsulation by Lim et al., this technology has received enormous attention. Several studies have been conducted to improve this technique; different polymers, either natural or synthetic, have been used as microcapsules` making materials and different substances as coating layers. Literature review leads us to the conclusion that alginate (Alg) multilayer microcapsules and, in particular, alginate-poly l-lysine (PLL)-alginate (APA) are the most used structures for live cell encapsulation. Although, disadvantages of PLL (e.g., weak mechanical strength and low biocompat...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Protective Effect of Crocin on Malathion-induced Cardiotoxicity in Rats: A Biochemical, ...
In this study, the protective effect of crocin on malathion (MTN) induced cardiotoxicity in rats in subacute exposure was evaluated. Rats were divided into 6 groups; control (normal saline); MTN (100 mg/kg); MTN + crocin (10, 20 and 40 mg/kg) and MTN + vitamin E 200 IU/kg. Treatments were continued for two weeks. Creatine phosphokinase MB (CK-MB), malondialdehyde (MDA) and glutathione (GSH) levels were evaluated in heart tissue at the end of treatments. The effect of crocin and MTN on histopathological changes in rat cardiac tissue was also investigated. The alteration of protein profile in the heart of the animals exposed...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Design, Synthesis, and Anticancer Activity Evaluation of Hybrids of Azoles and Barbituric Acids
In order to find new drugs with potent antiproliferative effect, a series of novel barbituric acid derivatives containing azoles at the C-5 position were designed, synthesized, and evaluated for antiproliferative activity against three human cancer cell lines (BEL-7402, MCF-7, and HCT-116) using MTT assay. Several of the synthesized compounds exhibited potent antiproliferative effects. The most promising compound was 5-((1-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl) methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (3s), which showed considerably high antiproliferative activity in the BEL-7402 cell line, with a half...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Protective Effect of Cinnamaldehyde on METH-induced Neurotoxicity in PC12 Cells via Inhibition ...
Methamphetamine (METH) is a potent central nervous system (CNS) stimulant and frequently used illegal drugs. Repeated exposure to METH can induce degenerative changes in dopaminergic and serotonergic axons. There is no standard medical treatment for METH’s neurotoxic effects. Cinnamaldehyde is an important compound of cinnamon and has activities against neurological disorders. The present study was designed to examine the neuroprotective effect of trans-cinnamaldehyde (TCA) on METH-induced cytotoxicity. PC12 cells were treated with METH (2.5 mM) 24 h after treated with different concentrations of TCA (3.75- 50μM)....
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Pharmacological Properties of Allium cepa, Preclinical and Clinical Evidences; A Review
Onion or Allium cepa (A. cepa) is one of the most important condiment plants grown and consumed all over the world. This plant has various therapeutic effects attributed to its constituents, such as quercetin, thiosulphinates and phenolic acids. In the present article, various pharmacological and therapeutic effects of A. cepa were reviewed. Different online databases using keywords such as onion, A. cepa, therapeutic effects, and pharmacological effects until the end of December 2019 were searched for this purpose. Onion has been suggested to be effective in treating a broad range of disorders, including asthma, inflammat...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Enhanced Neural Differentiation of Epidermal Neural Crest Stem Cell by Synergistic Effect of ...
In this study, the effect of Lithium carbonate and Crocin, with considering of their effects on cellular signaling pathways and neuroprotective properties were investigated on expression of neurotrophic factors BDNF and GDNF in EPI-NCSCs.EPI-NCSCs were isolated from hair follicle and after 72 hours of treatment with different concentration of drugs [Lithium, Crocin and lithium + Crocin], and trial doses were selected by MTT assay. The cells were treated with selected concentration (Lithium 1 mM, Crocin 1.5 mM, and for co-treatment Lithium 1mM and Crocin 1 mM) for 7 days.The Real Time PCR results indicated an increasing in ...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Protective Effect of Crocin against Mitochondrial Damage and Memory Deficit Induced by ...
In this study, the recovery effects of crocin on the memory deficits caused by the intra-hippocampal injection of amyloid beta1-42 (Aβ1-42) were evaluated in rats. We also considered the protective effects of crocin on the mitochondrial damage caused by Aβ1-42. We examined the memory deficits of rats with the help of the Morris water maze. Then, we determined different mitochondrial toxicity endpoints caused by Aβ1-42, including mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane potential collapse, mitochondrial outer membrane integrity, and cytochrome c release. Our results demonstrated...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Simple Determination of p-Cresol in Plasma Samples Using Fluorescence Spectroscopy Technique
The development of simple, fast, cheap and reliable analytical methods for tracing biological indicators is demanded through clinical investigations. Herein, we developed, for the first time, a cheap and specific method for the extraction and quantification of p-cresol (pC) in real plasma samples of chronic kidney disease (CKD). Plasma samples were prepared by hydrolyzing in an acidic medium to convert pCS (p-cresol sulfate) and p-Cresol glucuronide (pCG) to pC. Next, proteins of plasma samples were precipitated and then pC was extracted by acetonitrile (ACN) and saturated NaCl (as salting-out agent). Finally, fluorescence...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
Synergistic Cotreatment Potential of Soursop (Annona muricata L. ...
This study aims to unveil the anticancer activity of AME as a cotreatment agent with doxorubicin (dox) on 4T1 cells and AME’s relation to senescence. AME was obtained by maceration using 96% ethanol. AME was then subjected to qualitative analysis using TLC compared to quercetin (hRf = 75). Spectrophotometry analysis of AME resulted in a total flavonoid content of 2.3%± 0.05%. Cytotoxic evaluation using the MTT assay revealed that AME showed an IC50 value of 63µg/mL, while its combination (25µg/mL) with dox (10 nM) decreased the viability of 4T1 cells to 58 % (CI = 0.15). Flowcytometry using propidi...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
TRAIL Conjugated Silver Nanoparticle Synthesis, Characterization and Therapeutic Effects on ...
In this study, we aimed to develop a silver nanoparticle system conjugated with TRAIL and coated with PEG (AgCTP NPs) to improve the therapeutic effects of colon cancer. AgCTP NPs were characterized by UV spectrum, FTIR and zetasizer. Cytotoxicity, hemolysis assay and apoptotic effects of nanoparticles were investigated using a colon cancer cell line (HT-29) in-vitro. Treatment with AgCTP NPs effectively inhibited proliferation and colony formation of HT-29 cells. The apoptotic effects of nanoparticles on HT-29 cells were determined as Bax, Bcl-2, PARP and clv-PARP protein expression levels using Western blot. Apoptotic pr...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
The Effects of Spironolactone in Preventing Bile Duct Ligation-induced Hepatitis in A Rat Model
In conclusion, i t was observed that SPL administration significantly decreases liver inflammation and damage related to BDL. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - May 31, 2021 Category: Drugs & Pharmacology Source Type: research
